CDYL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.66070220
2cell wall macromolecule catabolic process (GO:0016998)5.35661540
3cell wall macromolecule metabolic process (GO:0044036)5.35661540
4sperm-egg recognition (GO:0035036)5.29844990
5sperm motility (GO:0030317)5.26853764
6nuclear pore complex assembly (GO:0051292)5.10497460
7binding of sperm to zona pellucida (GO:0007339)5.07100148
8nuclear pore organization (GO:0006999)4.84207308
9cell-cell recognition (GO:0009988)4.74767556
10multicellular organism reproduction (GO:0032504)4.68151073
11establishment of integrated proviral latency (GO:0075713)4.58987184
12pre-miRNA processing (GO:0031054)4.54160312
13acrosome assembly (GO:0001675)4.50072062
14CENP-A containing nucleosome assembly (GO:0034080)4.32885797
15synaptonemal complex assembly (GO:0007130)4.29274705
16pore complex assembly (GO:0046931)4.22524820
17motile cilium assembly (GO:0044458)4.20630610
18spermatid development (GO:0007286)4.18673552
19piRNA metabolic process (GO:0034587)4.12034070
20DNA replication-dependent nucleosome organization (GO:0034723)4.11179040
21DNA replication-dependent nucleosome assembly (GO:0006335)4.11179040
22male meiosis (GO:0007140)4.08178435
23chromosome condensation (GO:0030261)4.08149984
24synaptonemal complex organization (GO:0070193)4.05416724
25protein localization to chromosome, centromeric region (GO:0071459)3.99803694
26axonemal dynein complex assembly (GO:0070286)3.97142652
27plasma membrane fusion (GO:0045026)3.97098428
28paraxial mesoderm development (GO:0048339)3.97035526
29reproduction (GO:0000003)3.93003039
30microtubule depolymerization (GO:0007019)3.89131279
31mitotic G2/M transition checkpoint (GO:0044818)3.86869764
32acrosome reaction (GO:0007340)3.82633713
33negative regulation of chromosome segregation (GO:0051985)3.82525469
34negative regulation of mitotic sister chromatid separation (GO:2000816)3.81483033
35negative regulation of sister chromatid segregation (GO:0033046)3.81483033
36negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.81483033
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.81483033
38negative regulation of mitotic sister chromatid segregation (GO:0033048)3.81483033
39DNA packaging (GO:0006323)3.81399673
40mitotic sister chromatid cohesion (GO:0007064)3.80211131
41mitotic nuclear envelope disassembly (GO:0007077)3.78670869
42DNA replication-independent nucleosome organization (GO:0034724)3.69425315
43DNA replication-independent nucleosome assembly (GO:0006336)3.69425315
44epithelial cilium movement (GO:0003351)3.68892704
45cellular protein complex localization (GO:0034629)3.65667888
46cilium or flagellum-dependent cell motility (GO:0001539)3.60134617
47nuclear envelope disassembly (GO:0051081)3.56792427
48membrane disassembly (GO:0030397)3.56792427
49mitotic chromosome condensation (GO:0007076)3.53518439
50spindle checkpoint (GO:0031577)3.51091504
51regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50725424
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50725424
53establishment of viral latency (GO:0019043)3.50128320
54mitotic spindle checkpoint (GO:0071174)3.48888225
55heterochromatin organization (GO:0070828)3.48391908
56regulation of histone H3-K9 methylation (GO:0051570)3.47382685
57regulation of centriole replication (GO:0046599)3.46985596
58protein localization to kinetochore (GO:0034501)3.46402116
59regulation of sister chromatid segregation (GO:0033045)3.45301112
60regulation of mitotic sister chromatid separation (GO:0010965)3.45301112
61regulation of mitotic sister chromatid segregation (GO:0033047)3.45301112
62positive regulation of SMAD protein import into nucleus (GO:0060391)3.44355974
63DNA replication initiation (GO:0006270)3.44092506
64mitotic spindle assembly checkpoint (GO:0007094)3.38798842
65chromosome organization involved in meiosis (GO:0070192)3.38113278
66formation of translation preinitiation complex (GO:0001731)3.35603645
67mitotic G2 DNA damage checkpoint (GO:0007095)3.32155432
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32071576
69DNA unwinding involved in DNA replication (GO:0006268)3.31217027
70spindle assembly checkpoint (GO:0071173)3.29151308
71gene silencing by RNA (GO:0031047)3.26409475
72mitotic sister chromatid segregation (GO:0000070)3.26333258
73mitotic metaphase plate congression (GO:0007080)3.25951534
74meiotic nuclear division (GO:0007126)3.24489785
75histone exchange (GO:0043486)3.22957340
76positive regulation of chromosome segregation (GO:0051984)3.21481508
77ribosome assembly (GO:0042255)3.21052669
78L-serine metabolic process (GO:0006563)3.20018589
79ribosomal small subunit biogenesis (GO:0042274)3.17009568
80chromatin assembly (GO:0031497)3.15790675
81monoubiquitinated protein deubiquitination (GO:0035520)3.15246036
82regulation of helicase activity (GO:0051095)3.14804013
83ATP-dependent chromatin remodeling (GO:0043044)3.14153396
84anterior/posterior axis specification, embryo (GO:0008595)3.12666202
85sister chromatid segregation (GO:0000819)3.11998389
86single fertilization (GO:0007338)3.11434010
87DNA strand elongation involved in DNA replication (GO:0006271)3.07603382
88IMP biosynthetic process (GO:0006188)3.04623275
89regulation of cilium movement (GO:0003352)3.04292629
90regulation of gene silencing by RNA (GO:0060966)3.03928963
91regulation of posttranscriptional gene silencing (GO:0060147)3.03928963
92regulation of gene silencing by miRNA (GO:0060964)3.03928963
93negative regulation of mitosis (GO:0045839)3.01367297
94IMP metabolic process (GO:0046040)3.00628395
95* spermatogenesis (GO:0007283)2.99464600
96* male gamete generation (GO:0048232)2.99286417
97telomere maintenance via recombination (GO:0000722)2.98710698
98DNA strand elongation (GO:0022616)2.97129552
99meiotic chromosome segregation (GO:0045132)2.96541570
100meiotic cell cycle (GO:0051321)2.96323856
101DNA topological change (GO:0006265)2.95982082
102histone H2B ubiquitination (GO:0033523)2.94266335
103maturation of SSU-rRNA (GO:0030490)2.94231406
104DNA conformation change (GO:0071103)2.93974883
105male meiosis I (GO:0007141)2.93494225
106metaphase plate congression (GO:0051310)2.90739909
107fertilization (GO:0009566)2.90355326
108regulation of chromosome segregation (GO:0051983)2.90336438
109regulation of RNA export from nucleus (GO:0046831)2.89546989
110mitotic recombination (GO:0006312)2.89403394
111regulation of centrosome cycle (GO:0046605)2.88880051
112cilium movement (GO:0003341)2.88774838
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88772226
114positive regulation of mitotic sister chromatid separation (GO:1901970)2.88464084
115positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88464084
116positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88464084
117single strand break repair (GO:0000012)2.88416902
118chromatin remodeling at centromere (GO:0031055)2.88179748
119negative regulation of DNA repair (GO:0045738)2.87293928
120DNA duplex unwinding (GO:0032508)2.86585649
121protein K6-linked ubiquitination (GO:0085020)2.85658757
122negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.85625615
123regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85450272
124gene silencing (GO:0016458)2.83764705
125protein localization to chromosome (GO:0034502)2.83461560
126establishment of chromosome localization (GO:0051303)2.83373004
127* gamete generation (GO:0007276)2.82327430
128regulation of spindle checkpoint (GO:0090231)2.82193424
129DNA replication checkpoint (GO:0000076)2.81379901
130meiotic cell cycle process (GO:1903046)2.80943513
131sister chromatid cohesion (GO:0007062)2.80741920
132folic acid-containing compound biosynthetic process (GO:0009396)2.80542397
133non-recombinational repair (GO:0000726)2.78788234
134double-strand break repair via nonhomologous end joining (GO:0006303)2.78788234
135telomere maintenance via semi-conservative replication (GO:0032201)2.76253506
136nuclear envelope organization (GO:0006998)2.76143630
137chromatin assembly or disassembly (GO:0006333)2.75967064
138germ cell development (GO:0007281)2.75805451
139purine nucleobase biosynthetic process (GO:0009113)2.75211091
140regulation of translational fidelity (GO:0006450)2.75155744
141chromosome organization (GO:0051276)2.74991821
142chaperone-mediated protein complex assembly (GO:0051131)2.74335351
143positive regulation of catenin import into nucleus (GO:0035413)2.73217914
144attachment of spindle microtubules to kinetochore (GO:0008608)2.73110137
145negative regulation of histone methylation (GO:0031061)2.72446267
146ribosomal large subunit biogenesis (GO:0042273)2.71755450
147response to X-ray (GO:0010165)2.70625616
148nucleus organization (GO:0006997)2.70086541
149ribosomal small subunit assembly (GO:0000028)2.69943340
150DNA methylation involved in gamete generation (GO:0043046)2.68681141
151regulation of spindle organization (GO:0090224)2.67685961
152protein complex localization (GO:0031503)2.67283162
153mitotic DNA integrity checkpoint (GO:0044774)2.67260032
154DNA geometric change (GO:0032392)2.66976346
155kinetochore organization (GO:0051383)2.66880827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.77773972
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.58542613
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.12346723
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72082468
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21292513
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.98561881
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.68622618
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43567841
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29009088
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10691724
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.00693619
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.00434372
13MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92807767
14AR_21909140_ChIP-Seq_LNCAP_Human1.91781647
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86974795
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84892862
17NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80339708
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78573450
19MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76709924
20* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.76374398
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72853424
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68527068
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66290472
24* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65054530
25MYC_22102868_ChIP-Seq_BL_Human1.65050161
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62900635
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59351639
28* NANOG_16153702_ChIP-ChIP_HESCs_Human1.58366716
29XRN2_22483619_ChIP-Seq_HELA_Human1.50292806
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49840781
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.44922631
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44083682
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43344825
34* SOX2_16153702_ChIP-ChIP_HESCs_Human1.43323698
35VDR_23849224_ChIP-Seq_CD4+_Human1.43066153
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41278330
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39163510
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37031714
39SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.34246419
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33525518
41* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29210219
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28540452
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27733193
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27715077
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.25748094
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24329381
47DCP1A_22483619_ChIP-Seq_HELA_Human1.22037364
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.21466036
49SOX17_20123909_ChIP-Seq_XEN_Mouse1.20916885
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19995518
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.19851851
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19548254
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18728294
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18475693
55* FOXP3_21729870_ChIP-Seq_TREG_Human1.15921936
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15119081
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14203097
58ELK1_19687146_ChIP-ChIP_HELA_Human1.13886104
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12369362
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12164774
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.12003568
62ZNF263_19887448_ChIP-Seq_K562_Human1.11886297
63TTF2_22483619_ChIP-Seq_HELA_Human1.10798809
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10437430
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10437430
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10437430
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10210346
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10014948
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09709676
70KDM5A_27292631_Chip-Seq_BREAST_Human1.09159254
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08624608
72GABP_19822575_ChIP-Seq_HepG2_Human1.07799069
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06663715
74CHD1_26751641_Chip-Seq_LNCaP_Human1.06227841
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05412260
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05339572
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04392795
78MYB_26560356_Chip-Seq_TH2_Human1.02957739
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02632130
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.02403483
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01638395
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00702430
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00411705
84MYB_26560356_Chip-Seq_TH1_Human0.98910964
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.98286067
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97956460
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97945253
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94649359
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94545221
90GATA1_22025678_ChIP-Seq_K562_Human0.94087190
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93661805
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93487970
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93427049
94* TCF7_22412390_ChIP-Seq_EML_Mouse0.92917056
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91970270
96VDR_21846776_ChIP-Seq_THP-1_Human0.90711779
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89702360
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89260996
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89082982
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88988235
101* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88598150
102* SPI1_23547873_ChIP-Seq_NB4_Human0.88317020
103IRF8_21731497_ChIP-ChIP_J774_Mouse0.87765896
104CIITA_25753668_ChIP-Seq_RAJI_Human0.87494700
105RUNX1_22412390_ChIP-Seq_EML_Mouse0.87469959
106* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87397740
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86692071
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86376326
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86269809
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86197434
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86159828
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85066790
113MAF_26560356_Chip-Seq_TH1_Human0.85043056
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84669644
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.83710022
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82349189
117* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82205713
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81898283
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81506003
120TFEB_21752829_ChIP-Seq_HELA_Human0.80525064
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80194603
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.79982775
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78874857
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77145130
125YY1_21170310_ChIP-Seq_MESCs_Mouse0.77074731
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.74849309
127* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74041448
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73199134
129STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72715088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.62829471
2MP0010094_abnormal_chromosome_stability3.45251829
3MP0003111_abnormal_nucleus_morphology3.28818309
4MP0008057_abnormal_DNA_replication3.24100732
5MP0003693_abnormal_embryo_hatching3.00784923
6MP0008877_abnormal_DNA_methylation2.99978924
7MP0003077_abnormal_cell_cycle2.89873368
8MP0004957_abnormal_blastocyst_morpholog2.81803009
9MP0001929_abnormal_gametogenesis2.74200920
10MP0010352_gastrointestinal_tract_polyps2.52429758
11MP0010307_abnormal_tumor_latency2.45036580
12MP0003698_abnormal_male_reproductive2.38623843
13MP0002254_reproductive_system_inflammat2.31019019
14MP0002210_abnormal_sex_determination2.23979082
15MP0008058_abnormal_DNA_repair2.23925455
16MP0003136_yellow_coat_color2.19658598
17MP0008007_abnormal_cellular_replicative2.15341831
18MP0001145_abnormal_male_reproductive1.98897617
19MP0002877_abnormal_melanocyte_morpholog1.97495578
20MP0002796_impaired_skin_barrier1.97259298
21MP0009672_abnormal_birth_weight1.94759040
22MP0001730_embryonic_growth_arrest1.88331927
23MP0005076_abnormal_cell_differentiation1.82761117
24MP0000350_abnormal_cell_proliferation1.82530241
25MP0004185_abnormal_adipocyte_glucose1.77461650
26MP0009697_abnormal_copulation1.76085047
27MP0003656_abnormal_erythrocyte_physiolo1.73549881
28MP0006292_abnormal_olfactory_placode1.73066926
29MP0008932_abnormal_embryonic_tissue1.69578279
30MP0000653_abnormal_sex_gland1.68153084
31MP0002653_abnormal_ependyma_morphology1.66737727
32MP0003123_paternal_imprinting1.65118124
33MP0001545_abnormal_hematopoietic_system1.58817151
34MP0005397_hematopoietic_system_phenotyp1.58817151
35MP0005380_embryogenesis_phenotype1.54096482
36MP0001672_abnormal_embryogenesis/_devel1.54096482
37MP0005501_abnormal_skin_physiology1.54094854
38MP0002161_abnormal_fertility/fecundity1.48926946
39MP0001697_abnormal_embryo_size1.44617127
40MP0002697_abnormal_eye_size1.42882510
41MP0003984_embryonic_growth_retardation1.41823084
42MP0009278_abnormal_bone_marrow1.41110592
43MP0000490_abnormal_crypts_of1.40784844
44MP0002086_abnormal_extraembryonic_tissu1.40016558
45MP0001293_anophthalmia1.37758779
46MP0002088_abnormal_embryonic_growth/wei1.37603499
47MP0004197_abnormal_fetal_growth/weight/1.36751163
48MP0000428_abnormal_craniofacial_morphol1.35358905
49MP0002084_abnormal_developmental_patter1.35135685
50MP0004808_abnormal_hematopoietic_stem1.34665683
51MP0002085_abnormal_embryonic_tissue1.33528461
52MP0009703_decreased_birth_body1.32696119
53MP0002396_abnormal_hematopoietic_system1.29104424
54MP0000579_abnormal_nail_morphology1.28858670
55MP0005623_abnormal_meninges_morphology1.28206798
56MP0003786_premature_aging1.25674714
57MP0003705_abnormal_hypodermis_morpholog1.24852899
58MP0002080_prenatal_lethality1.22765809
59MP0000313_abnormal_cell_death1.21223748
60MP0004272_abnormal_basement_membrane1.20266432
61MP0004233_abnormal_muscle_weight1.18820890
62MP0008260_abnormal_autophagy1.18475030
63MP0002019_abnormal_tumor_incidence1.16483704
64MP0000858_altered_metastatic_potential1.16306175
65MP0010030_abnormal_orbit_morphology1.16233253
66MP0001286_abnormal_eye_development1.15814448
67MP0003890_abnormal_embryonic-extraembry1.11540119
68MP0003186_abnormal_redox_activity1.10728712
69MP0002398_abnormal_bone_marrow1.09122499
70MP0000685_abnormal_immune_system1.06370449
71MP0000516_abnormal_urinary_system1.05216153
72MP0005367_renal/urinary_system_phenotyp1.05216153
73MP0002405_respiratory_system_inflammati1.04032870
74MP0009379_abnormal_foot_pigmentation1.03733658
75MP0002111_abnormal_tail_morphology1.03380142
76MP0003566_abnormal_cell_adhesion1.01254029
77MP0000358_abnormal_cell_content/1.00578754
78MP0001915_intracranial_hemorrhage0.99750667
79MP0005023_abnormal_wound_healing0.97244968
80MP0003567_abnormal_fetal_cardiomyocyte0.95790760
81MP0002160_abnormal_reproductive_system0.95484409
82MP0000647_abnormal_sebaceous_gland0.94950714
83MP0005257_abnormal_intraocular_pressure0.94458436
84MP0003436_decreased_susceptibility_to0.93590413
85MP0003121_genomic_imprinting0.93300769
86MP0009053_abnormal_anal_canal0.92909458
87MP0000703_abnormal_thymus_morphology0.92670149
88MP0005384_cellular_phenotype0.91601937
89MP0005464_abnormal_platelet_physiology0.91489856
90MP0009333_abnormal_splenocyte_physiolog0.91428753
91MP0002282_abnormal_trachea_morphology0.90009062
92MP0003448_altered_tumor_morphology0.89949530
93MP0001849_ear_inflammation0.89889055
94MP0001835_abnormal_antigen_presentation0.89822296
95MP0002722_abnormal_immune_system0.89162376
96MP0000689_abnormal_spleen_morphology0.87790875
97MP0003806_abnormal_nucleotide_metabolis0.86168884
98MP0000383_abnormal_hair_follicle0.84833328
99MP0001853_heart_inflammation0.83933895
100MP0005408_hypopigmentation0.83239339
101MP0002092_abnormal_eye_morphology0.82503707
102MP0001216_abnormal_epidermal_layer0.80907806
103MP0002233_abnormal_nose_morphology0.80742022
104MP0002060_abnormal_skin_morphology0.80062550
105MP0002429_abnormal_blood_cell0.79754454
106MP0001119_abnormal_female_reproductive0.79006373
107MP0002452_abnormal_antigen_presenting0.78992262
108MP0010678_abnormal_skin_adnexa0.78817942
109MP0001800_abnormal_humoral_immune0.78799608
110MP0003763_abnormal_thymus_physiology0.77426888
111MP0006035_abnormal_mitochondrial_morpho0.77130067
112MP0004133_heterotaxia0.76349849
113MP0000733_abnormal_muscle_development0.74885888
114MP0002925_abnormal_cardiovascular_devel0.74488059
115MP0010234_abnormal_vibrissa_follicle0.72876495
116MP0000716_abnormal_immune_system0.72797328
117MP0000762_abnormal_tongue_morphology0.71855448
118MP0002420_abnormal_adaptive_immunity0.70946211
119MP0001819_abnormal_immune_cell0.70264257
120MP0003115_abnormal_respiratory_system0.70095628
121MP0003119_abnormal_digestive_system0.69925961
122MP0003878_abnormal_ear_physiology0.69222679
123MP0005377_hearing/vestibular/ear_phenot0.69222679
124MP0005000_abnormal_immune_tolerance0.67786571
125MP0005174_abnormal_tail_pigmentation0.67337604
126MP0006054_spinal_hemorrhage0.67245706
127MP0003718_maternal_effect0.67162504
128MP0002723_abnormal_immune_serum0.65533585
129MP0003221_abnormal_cardiomyocyte_apopto0.65382800
130MP0005666_abnormal_adipose_tissue0.65148531
131MP0001188_hyperpigmentation0.64922879
132MP0005083_abnormal_biliary_tract0.64853696
133MP0003950_abnormal_plasma_membrane0.64301914
134MP0003935_abnormal_craniofacial_develop0.64073278
135MP0003941_abnormal_skin_development0.63899239
136MP0005025_abnormal_response_to0.63264758
137MP0003453_abnormal_keratinocyte_physiol0.63097292
138MP0003303_peritoneal_inflammation0.62961195
139MP0005389_reproductive_system_phenotype0.62737493
140MP0003936_abnormal_reproductive_system0.62613534
141MP0005621_abnormal_cell_physiology0.62283367
142MP0000371_diluted_coat_color0.62141541
143MP0000432_abnormal_head_morphology0.61841653
144MP0004264_abnormal_extraembryonic_tissu0.60893476
145MP0003937_abnormal_limbs/digits/tail_de0.60066710
146MP0000537_abnormal_urethra_morphology0.58929376
147MP0010771_integument_phenotype0.57902966

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.78789227
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.86512734
3Absent/shortened dynein arms (HP:0200106)5.86512734
4Abnormal respiratory motile cilium physiology (HP:0012261)4.36644092
5Nasal polyposis (HP:0100582)4.04588386
6Abnormal respiratory epithelium morphology (HP:0012253)4.03601702
7Abnormal respiratory motile cilium morphology (HP:0005938)4.03601702
8Septo-optic dysplasia (HP:0100842)3.85227829
9Chronic bronchitis (HP:0004469)3.80672227
10Rhinitis (HP:0012384)3.70421264
11Male infertility (HP:0003251)3.42023699
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.40709791
13Abnormality of the nasal mucosa (HP:0000433)3.33079986
14Infertility (HP:0000789)3.22945113
15Abnormal ciliary motility (HP:0012262)3.11904745
16Impulsivity (HP:0100710)3.08373909
17Spastic diplegia (HP:0001264)3.05970874
18Birth length less than 3rd percentile (HP:0003561)3.05362382
19Multiple enchondromatosis (HP:0005701)3.05154610
20Bronchitis (HP:0012387)2.91892552
21Abnormal spermatogenesis (HP:0008669)2.90972632
22Selective tooth agenesis (HP:0001592)2.83460316
23Supernumerary spleens (HP:0009799)2.75625002
24Chromsome breakage (HP:0040012)2.75433652
25Bronchiectasis (HP:0002110)2.73962609
26Maternal diabetes (HP:0009800)2.66991100
27Abnormality of the septum pellucidum (HP:0007375)2.64151852
28Medulloblastoma (HP:0002885)2.62620247
29Abnormal auditory evoked potentials (HP:0006958)2.56321663
30Gastrointestinal carcinoma (HP:0002672)2.54291707
31Malignant gastrointestinal tract tumors (HP:0006749)2.54291707
32Papillary thyroid carcinoma (HP:0002895)2.51155580
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48760299
34Abnormality of chromosome stability (HP:0003220)2.46482274
35Hypoplastic pelvis (HP:0008839)2.38266018
36Absent septum pellucidum (HP:0001331)2.34209229
37Agnosia (HP:0010524)2.34102417
38Uterine leiomyosarcoma (HP:0002891)2.32910254
39Leiomyosarcoma (HP:0100243)2.32910254
40Meckel diverticulum (HP:0002245)2.32830497
41Recurrent bronchitis (HP:0002837)2.32706102
42Breast hypoplasia (HP:0003187)2.32241829
43Nephronophthisis (HP:0000090)2.31903842
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.31223324
45Ectopic kidney (HP:0000086)2.29526297
46Increased mean platelet volume (HP:0011877)2.28831890
47Skull defect (HP:0001362)2.27120164
48Abnormality of the ileum (HP:0001549)2.24315239
49Ependymoma (HP:0002888)2.21266128
50Cleft eyelid (HP:0000625)2.21104845
51Deep philtrum (HP:0002002)2.20756741
52Aplasia/hypoplasia of the humerus (HP:0006507)2.19893156
53Short 4th metacarpal (HP:0010044)2.18796080
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18796080
55Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.18430595
56Abnormality of abdominal situs (HP:0011620)2.16605603
57Abdominal situs inversus (HP:0003363)2.16605603
58Abnormal hair whorl (HP:0010721)2.16484318
59Short humerus (HP:0005792)2.15922007
60Uterine neoplasm (HP:0010784)2.13575341
61Transitional cell carcinoma of the bladder (HP:0006740)2.13192491
62Abnormal number of incisors (HP:0011064)2.12684558
63Absent thumb (HP:0009777)2.09535817
64Increased nuchal translucency (HP:0010880)2.09015105
65Aqueductal stenosis (HP:0002410)2.08932258
66Sloping forehead (HP:0000340)2.07582439
67Missing ribs (HP:0000921)2.06223183
68Abnormality of the anterior horn cell (HP:0006802)2.05023830
69Degeneration of anterior horn cells (HP:0002398)2.05023830
70Rectal fistula (HP:0100590)2.03386970
71Rectovaginal fistula (HP:0000143)2.03386970
72Breast aplasia (HP:0100783)2.03268697
73Myelodysplasia (HP:0002863)2.02970528
74Esophageal atresia (HP:0002032)2.02819586
75Choanal stenosis (HP:0000452)2.01898377
76Patellar aplasia (HP:0006443)2.00223303
77Small intestinal stenosis (HP:0012848)1.99712929
78Duodenal stenosis (HP:0100867)1.99712929
79Rhabdomyosarcoma (HP:0002859)1.99537126
80Aplasia/Hypoplasia of the breasts (HP:0010311)1.98616422
81Short middle phalanx of the 5th finger (HP:0004220)1.98186100
82Myelomeningocele (HP:0002475)1.97345983
83Cortical dysplasia (HP:0002539)1.96578320
8411 pairs of ribs (HP:0000878)1.96355933
85Septate vagina (HP:0001153)1.95050593
86Bladder neoplasm (HP:0009725)1.94095050
87Bladder carcinoma (HP:0002862)1.94095050
88Recurrent otitis media (HP:0000403)1.92691781
89Absent radius (HP:0003974)1.90903764
90Abnormality of the preputium (HP:0100587)1.89372031
91Duplication of thumb phalanx (HP:0009942)1.88506641
92Basal cell carcinoma (HP:0002671)1.87859362
93Nephroblastoma (Wilms tumor) (HP:0002667)1.86737643
94Abnormality of the salivary glands (HP:0010286)1.86648773
95Abnormality of the nasolacrimal system (HP:0000614)1.86540639
96Azoospermia (HP:0000027)1.84694028
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84661466
98Aplasia/Hypoplasia of the patella (HP:0006498)1.83857093
99Abnormal platelet volume (HP:0011876)1.83716004
100Neoplasm of the oral cavity (HP:0100649)1.83643854
101Reticulocytopenia (HP:0001896)1.83426130
102Hepatoblastoma (HP:0002884)1.83364502
103Recurrent sinusitis (HP:0011108)1.82741988
104Cafe-au-lait spot (HP:0000957)1.82664757
105Heterotopia (HP:0002282)1.82232985
106Glioma (HP:0009733)1.81208426
107Abnormal lung lobation (HP:0002101)1.80945001
108High pitched voice (HP:0001620)1.79818355
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79047185
110Vaginal fistula (HP:0004320)1.78258314
111Colon cancer (HP:0003003)1.77950155
112Cellular immunodeficiency (HP:0005374)1.77730888
113Progressive muscle weakness (HP:0003323)1.77714389
114Neoplasm of the pancreas (HP:0002894)1.77617519
115Neoplasm of the colon (HP:0100273)1.77106388
116Neoplasm of the small intestine (HP:0100833)1.76745662
117Ankyloglossia (HP:0010296)1.76308949
118Macrocytic anemia (HP:0001972)1.76095379
119Hemivertebrae (HP:0002937)1.75455505
120Abnormality of the lacrimal duct (HP:0011481)1.75225779
121Wide nose (HP:0000445)1.74687717
122Atresia of the external auditory canal (HP:0000413)1.74640829
123Prominent nose (HP:0000448)1.74623613
124Tracheoesophageal fistula (HP:0002575)1.74262186
125Embryonal neoplasm (HP:0002898)1.73855093
126Choanal atresia (HP:0000453)1.73735550
127Sensory axonal neuropathy (HP:0003390)1.73733763
128Intestinal fistula (HP:0100819)1.72976198
129Horseshoe kidney (HP:0000085)1.72950240
130Bilateral microphthalmos (HP:0007633)1.72541729
131Absent forearm bone (HP:0003953)1.72431980
132Aplasia involving forearm bones (HP:0009822)1.72431980
133Poikilocytosis (HP:0004447)1.71939563
134Acute myeloid leukemia (HP:0004808)1.71825076
135IgA deficiency (HP:0002720)1.71592677
136Carpal bone hypoplasia (HP:0001498)1.71164563
137Supernumerary ribs (HP:0005815)1.71023421
138Embryonal renal neoplasm (HP:0011794)1.70489162
139Neoplasm of striated muscle (HP:0009728)1.68693841
140Short ribs (HP:0000773)1.68270597
141Abnormality of cells of the erythroid lineage (HP:0012130)1.68015847
142Deviation of the thumb (HP:0009603)1.65478781
143Facial cleft (HP:0002006)1.65346216
144Recurrent abscess formation (HP:0002722)1.64799610
145Rib fusion (HP:0000902)1.64610400
146Oral leukoplakia (HP:0002745)1.62684759
147Bone marrow hypocellularity (HP:0005528)1.61700086
148Premature ovarian failure (HP:0008209)1.61519425
149Facial hemangioma (HP:0000329)1.61159891
150Supernumerary bones of the axial skeleton (HP:0009144)1.59084746
151Abnormality of the duodenum (HP:0002246)1.58491383
152Abnormality of the renal medulla (HP:0100957)1.58081264
153Proximal placement of thumb (HP:0009623)1.56664631
154Abnormal number of erythroid precursors (HP:0012131)1.56565369
155Squamous cell carcinoma (HP:0002860)1.56159244
156Porencephaly (HP:0002132)1.55546308
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.55158074
158Short thumb (HP:0009778)1.54493895
159Biliary tract neoplasm (HP:0100574)1.52794328
160Abnormality of the carotid arteries (HP:0005344)1.52177808
161Metaphyseal cupping (HP:0003021)1.51308640
162Abnormality of the labia minora (HP:0012880)1.50833079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.46362984
2CDK123.40154244
3PDK43.39574552
4PDK33.39574552
5TESK13.39325365
6NEK22.93691718
7WEE12.88844086
8TTK2.36695953
9STK102.36143493
10ICK2.33241422
11PDK22.23206951
12EIF2AK12.15404880
13MAP3K102.13828236
14TAF12.11380326
15PLK42.04094623
16BUB12.02343807
17TNIK1.99254615
18ACVR1B1.97741302
19PRKD31.82248270
20EEF2K1.78147379
21LATS11.67083206
22STK31.66306215
23CHEK21.54262844
24CDK71.54139521
25DYRK31.48681962
26PLK11.48465557
27ATR1.44641240
28SRPK11.37893322
29CDK41.37852934
30PIM11.35948959
31CDK61.34047059
32TYRO31.32254391
33VRK21.28995161
34TESK21.28269461
35CHEK11.26485857
36MAP3K81.24349018
37STK41.23975536
38STK391.21639562
39AURKB1.20441017
40RPS6KB21.20149878
41BRSK21.20041796
42RPS6KA41.16743955
43CAMK1G1.14435804
44PASK1.05947789
45WNK11.05929419
46MAP4K11.04184511
47CAMK1D1.03427239
48PNCK1.00433592
49TGFBR11.00096474
50FGFR10.99962429
51ATM0.99869007
52PAK40.97222822
53FGR0.96268761
54STK160.93810966
55PBK0.90997877
56VRK10.90971667
57BRD40.87397033
58PLK30.78663176
59STK38L0.78643716
60MELK0.78620445
61DYRK1B0.78071580
62PIM20.77297385
63TYK20.76224573
64WNK40.75742053
65NME20.75706739
66ERBB40.74416281
67MKNK10.74173876
68DMPK0.74022294
69KDR0.74000287
70CDK20.73989943
71NUAK10.73541645
72EPHA20.72393229
73BRAF0.71393017
74MTOR0.70811851
75SMG10.70618344
76TRIM280.70600129
77NEK10.69358608
78PTK2B0.68130621
79LRRK20.66455753
80EIF2AK30.65717425
81AURKA0.62713278
82CSK0.62089034
83TLK10.60507921
84BTK0.58668000
85CHUK0.58304277
86PAK10.58063666
87PDGFRA0.57185373
88MET0.56495701
89MAP3K60.55916233
90FLT30.55409309
91BMX0.54056524
92ZAP700.53900573
93IKBKB0.53689662
94PKN20.51853116
95MKNK20.51446162
96MARK30.51072815
97PLK20.51056730
98MST40.50771473
99CSNK1E0.50566930
100CDK10.48966755
101ILK0.48806971
102JAK30.48681946
103MAPKAPK30.48258629
104TEC0.47877753
105CDK90.45878036
106ALK0.45771912
107CDK30.45713305
108TSSK60.45223788
109NME10.44962194
110MATK0.44573225
111ZAK0.43727500
112CLK10.42941052
113PAK20.42493465
114IRAK30.41880710
115CSNK2A20.41223131
116MAP3K90.40927417
117LATS20.38362995
118IRAK20.38227142
119SCYL20.38127945
120KSR10.37601483
121CSF1R0.37243454
122YES10.36862480
123RPS6KA50.35555889
124NLK0.35315288
125PRKDC0.34333450
126CSNK2A10.34147369
127ITK0.33528661
128NEK60.33080400
129PRPF4B0.33022032
130EGFR0.32484288
131STK240.32246557
132MAP3K50.32035664
133TTN0.31987541
134EIF2AK20.31599140
135BRSK10.31423195
136MAP3K110.31057510

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.87157793
2Mismatch repair_Homo sapiens_hsa034303.12621976
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07348632
4RNA transport_Homo sapiens_hsa030132.80554303
5Cell cycle_Homo sapiens_hsa041102.66595387
6Homologous recombination_Homo sapiens_hsa034402.61413162
7Basal transcription factors_Homo sapiens_hsa030222.55164103
8Base excision repair_Homo sapiens_hsa034102.52864236
9Spliceosome_Homo sapiens_hsa030402.36890537
10Fanconi anemia pathway_Homo sapiens_hsa034602.23564050
11Nucleotide excision repair_Homo sapiens_hsa034202.11282381
12mRNA surveillance pathway_Homo sapiens_hsa030152.01225824
13RNA degradation_Homo sapiens_hsa030181.87478738
14p53 signaling pathway_Homo sapiens_hsa041151.75278930
15RNA polymerase_Homo sapiens_hsa030201.71131633
16Systemic lupus erythematosus_Homo sapiens_hsa053221.68436990
17Antigen processing and presentation_Homo sapiens_hsa046121.62335997
18One carbon pool by folate_Homo sapiens_hsa006701.60630276
19Pyrimidine metabolism_Homo sapiens_hsa002401.55974621
20Non-homologous end-joining_Homo sapiens_hsa034501.52587032
21Herpes simplex infection_Homo sapiens_hsa051681.47495384
22Ribosome_Homo sapiens_hsa030101.46041816
23Viral carcinogenesis_Homo sapiens_hsa052031.37539495
24Epstein-Barr virus infection_Homo sapiens_hsa051691.25217341
25Legionellosis_Homo sapiens_hsa051341.22902230
26Steroid biosynthesis_Homo sapiens_hsa001001.21597780
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19637687
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19076030
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.18773797
30Oocyte meiosis_Homo sapiens_hsa041141.18751691
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.16138015
32Bladder cancer_Homo sapiens_hsa052191.09719079
33Measles_Homo sapiens_hsa051621.09561225
34Proteasome_Homo sapiens_hsa030501.08688601
35Vitamin B6 metabolism_Homo sapiens_hsa007501.08435650
36Small cell lung cancer_Homo sapiens_hsa052221.06217527
37HTLV-I infection_Homo sapiens_hsa051661.02907648
38Tight junction_Homo sapiens_hsa045300.99610581
39MicroRNAs in cancer_Homo sapiens_hsa052060.99154397
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98774890
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95953423
42Viral myocarditis_Homo sapiens_hsa054160.95327763
43Endometrial cancer_Homo sapiens_hsa052130.93736815
44Purine metabolism_Homo sapiens_hsa002300.89350885
45Adherens junction_Homo sapiens_hsa045200.89053995
46TGF-beta signaling pathway_Homo sapiens_hsa043500.88644964
47Allograft rejection_Homo sapiens_hsa053300.87760118
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87477517
49Influenza A_Homo sapiens_hsa051640.86333448
50Leishmaniasis_Homo sapiens_hsa051400.85692568
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85199760
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84796627
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84520400
54Toxoplasmosis_Homo sapiens_hsa051450.84148967
55Wnt signaling pathway_Homo sapiens_hsa043100.83958916
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82383935
57Apoptosis_Homo sapiens_hsa042100.81829122
58Proteoglycans in cancer_Homo sapiens_hsa052050.80868858
59Primary immunodeficiency_Homo sapiens_hsa053400.79556107
60Shigellosis_Homo sapiens_hsa051310.78859349
61Asthma_Homo sapiens_hsa053100.78680527
62Malaria_Homo sapiens_hsa051440.77390542
63Melanoma_Homo sapiens_hsa052180.76895599
64Pentose phosphate pathway_Homo sapiens_hsa000300.76869338
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76573803
66Acute myeloid leukemia_Homo sapiens_hsa052210.75356878
67Chronic myeloid leukemia_Homo sapiens_hsa052200.70624551
68Selenocompound metabolism_Homo sapiens_hsa004500.69216381
69Hepatitis B_Homo sapiens_hsa051610.69011788
70Non-small cell lung cancer_Homo sapiens_hsa052230.68358487
71Glutathione metabolism_Homo sapiens_hsa004800.68201940
72Fatty acid biosynthesis_Homo sapiens_hsa000610.68137776
73B cell receptor signaling pathway_Homo sapiens_hsa046620.67683854
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66740104
75Renal cell carcinoma_Homo sapiens_hsa052110.65366636
76Colorectal cancer_Homo sapiens_hsa052100.65032407
77Basal cell carcinoma_Homo sapiens_hsa052170.64488701
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.64015946
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63026178
80Hippo signaling pathway_Homo sapiens_hsa043900.62315875
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61391204
82Thyroid cancer_Homo sapiens_hsa052160.61093104
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60270089
84Graft-versus-host disease_Homo sapiens_hsa053320.58853504
85Pancreatic cancer_Homo sapiens_hsa052120.58721153
86Osteoclast differentiation_Homo sapiens_hsa043800.57582155
87Folate biosynthesis_Homo sapiens_hsa007900.56511322
88Hematopoietic cell lineage_Homo sapiens_hsa046400.56436853
89Notch signaling pathway_Homo sapiens_hsa043300.56399678
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55805422
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55786785
92Prostate cancer_Homo sapiens_hsa052150.55591371
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54425991
94TNF signaling pathway_Homo sapiens_hsa046680.54055636
95Hedgehog signaling pathway_Homo sapiens_hsa043400.53467187
96Linoleic acid metabolism_Homo sapiens_hsa005910.53367015
97ECM-receptor interaction_Homo sapiens_hsa045120.52472119
98Salmonella infection_Homo sapiens_hsa051320.51881256
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51716074
100Galactose metabolism_Homo sapiens_hsa000520.51576380
101Dorso-ventral axis formation_Homo sapiens_hsa043200.51490464
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.50139701
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48937254
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48209727
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.47527478
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.47364229
107T cell receptor signaling pathway_Homo sapiens_hsa046600.47285669
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47135528
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45862397
110Lysine degradation_Homo sapiens_hsa003100.45856398
111Pyruvate metabolism_Homo sapiens_hsa006200.45493260
112Pathways in cancer_Homo sapiens_hsa052000.44932355
113HIF-1 signaling pathway_Homo sapiens_hsa040660.44662439
114Biosynthesis of amino acids_Homo sapiens_hsa012300.43766475
115Huntingtons disease_Homo sapiens_hsa050160.42494536
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42390710
117Platelet activation_Homo sapiens_hsa046110.41906058
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41256687
119VEGF signaling pathway_Homo sapiens_hsa043700.41095356
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40595264
121mTOR signaling pathway_Homo sapiens_hsa041500.40382795
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39821497
123Alcoholism_Homo sapiens_hsa050340.39377175
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39325473
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38924858
126Renin-angiotensin system_Homo sapiens_hsa046140.37649796
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36113602
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32859508
129FoxO signaling pathway_Homo sapiens_hsa040680.31672942
130Carbon metabolism_Homo sapiens_hsa012000.31546040
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30958871
132Focal adhesion_Homo sapiens_hsa045100.30088297
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29565987

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