CEACAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bile acid and bile salt transport (GO:0015721)8.53432015
2pyrimidine-containing compound transmembrane transport (GO:0072531)8.32980458
3vitamin transmembrane transport (GO:0035461)7.84023523
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.53915839
5sulfur amino acid catabolic process (GO:0000098)5.44623127
6regulation of guanylate cyclase activity (GO:0031282)5.06278074
7cellular ketone body metabolic process (GO:0046950)4.96784772
8maintenance of gastrointestinal epithelium (GO:0030277)4.93949669
9positive regulation of glycoprotein biosynthetic process (GO:0010560)4.90242139
10artery development (GO:0060840)4.49532973
11regulation of protein glycosylation (GO:0060049)4.47651800
12very-low-density lipoprotein particle assembly (GO:0034379)4.44771082
13negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.40525080
14positive regulation of guanylate cyclase activity (GO:0031284)4.40173736
15positive regulation of glycoprotein metabolic process (GO:1903020)4.36316997
16negative regulation of protein tyrosine kinase activity (GO:0061099)4.32254402
17macrophage chemotaxis (GO:0048246)4.32102645
18ketone body metabolic process (GO:1902224)4.30343206
19regulation of protein activation cascade (GO:2000257)4.26522521
20regulation of complement activation (GO:0030449)4.25279973
21positive regulation of respiratory burst (GO:0060267)4.22235000
22regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.19628797
23ethanol oxidation (GO:0006069)4.16943481
24low-density lipoprotein particle remodeling (GO:0034374)4.07297227
25complement activation, classical pathway (GO:0006958)4.07221408
26desmosome organization (GO:0002934)4.05612507
27plasma lipoprotein particle assembly (GO:0034377)4.02990355
28flavonoid metabolic process (GO:0009812)4.02534103
293-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.02476769
30purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.02476769
31kynurenine metabolic process (GO:0070189)3.99485189
32phosphatidylcholine biosynthetic process (GO:0006656)3.95763494
33negative regulation of protein activation cascade (GO:2000258)3.91900229
34sulfate transmembrane transport (GO:1902358)3.90200654
35indole-containing compound catabolic process (GO:0042436)3.89059515
36indolalkylamine catabolic process (GO:0046218)3.89059515
37tryptophan catabolic process (GO:0006569)3.89059515
38sulfur compound transport (GO:0072348)3.87851091
39epithelial structure maintenance (GO:0010669)3.85227711
40negative regulation of fibrinolysis (GO:0051918)3.82002764
41production of molecular mediator involved in inflammatory response (GO:0002532)3.78767714
42intestinal absorption (GO:0050892)3.74377473
43negative regulation of complement activation (GO:0045916)3.70538084
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.70359944
45calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.68976250
46intestinal epithelial cell development (GO:0060576)3.68421926
47regulation of bile acid biosynthetic process (GO:0070857)3.67600166
48negative regulation of cholesterol transport (GO:0032375)3.62918215
49negative regulation of sterol transport (GO:0032372)3.62918215
50diacylglycerol metabolic process (GO:0046339)3.58401680
51peptidyl-tyrosine autophosphorylation (GO:0038083)3.56033884
52cellular glucuronidation (GO:0052695)3.54989095
53regulation of fibrinolysis (GO:0051917)3.54112295
54homocysteine metabolic process (GO:0050667)3.54036784
55protein-lipid complex assembly (GO:0065005)3.53869455
56tryptophan metabolic process (GO:0006568)3.49374045
57protein-lipid complex remodeling (GO:0034368)3.48279252
58macromolecular complex remodeling (GO:0034367)3.48279252
59plasma lipoprotein particle remodeling (GO:0034369)3.48279252
60positive regulation of interleukin-1 secretion (GO:0050716)3.47740546
61UDP-N-acetylglucosamine metabolic process (GO:0006047)3.47594521
62aromatic amino acid family catabolic process (GO:0009074)3.44395105
63complement activation (GO:0006956)3.42548058
64phospholipid efflux (GO:0033700)3.41224712
65protein activation cascade (GO:0072376)3.41112266
66neurotransmitter biosynthetic process (GO:0042136)3.38906475
67regulation of cGMP biosynthetic process (GO:0030826)3.36183069
68drug transmembrane transport (GO:0006855)3.34621140
69plasma lipoprotein particle organization (GO:0071827)3.32763078
70regulation of systemic arterial blood pressure by hormone (GO:0001990)3.32107853
71regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.32107853
72endocrine process (GO:0050886)3.32107853
73epoxygenase P450 pathway (GO:0019373)3.31084832
74regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.30110978
75regulation of histone phosphorylation (GO:0033127)3.26832140
76peptidyl-glutamic acid carboxylation (GO:0017187)3.25004086
77protein carboxylation (GO:0018214)3.25004086
78regulation of interleukin-1 secretion (GO:0050704)3.24830870
79regulation of cholesterol metabolic process (GO:0090181)3.24612508
80renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.23210295
81phosphate ion transmembrane transport (GO:0035435)3.20841159
82complement activation, alternative pathway (GO:0006957)3.19191431
83nucleoside bisphosphate biosynthetic process (GO:0033866)3.19170280
84purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.19170280
85ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.19170280
86cholesterol efflux (GO:0033344)3.19105528
87acute-phase response (GO:0006953)3.18550305
88bicarbonate transport (GO:0015701)3.18401761
89regulation of cholesterol esterification (GO:0010872)3.18328194
90digestive system process (GO:0022600)3.15775712
91drug catabolic process (GO:0042737)3.15383458
92negative regulation of leukocyte chemotaxis (GO:0002689)3.15063003
93lymphocyte chemotaxis (GO:0048247)3.14224606
94uronic acid metabolic process (GO:0006063)3.12895795
95glucuronate metabolic process (GO:0019585)3.12895795
96arginine metabolic process (GO:0006525)3.10974541
97protein-lipid complex subunit organization (GO:0071825)3.10226058
98sulfate transport (GO:0008272)3.10075048
99azole transport (GO:0045117)3.09475347
100negative regulation of humoral immune response (GO:0002921)3.09433705
101drug transport (GO:0015893)3.09402293
102regulation of respiratory burst (GO:0060263)3.07080716
103vitamin transport (GO:0051180)3.06789094
104high-density lipoprotein particle remodeling (GO:0034375)3.05902190
105morphogenesis of an epithelial fold (GO:0060571)3.05819048
106positive regulation of lipid catabolic process (GO:0050996)3.05236213
107regulation of T cell tolerance induction (GO:0002664)3.04193858
108intestinal cholesterol absorption (GO:0030299)3.03668056
109regulation of cellular extravasation (GO:0002691)3.00279749
110bile acid metabolic process (GO:0008206)2.97615986
111regulation of sterol transport (GO:0032371)2.97179054
112regulation of cholesterol transport (GO:0032374)2.97179054
113regulation of triglyceride catabolic process (GO:0010896)2.94665839
114DNA damage induced protein phosphorylation (GO:0006975)2.94594955
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92674192
116glomerular filtration (GO:0003094)2.91494582
117negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.90957128
118renal system process involved in regulation of blood volume (GO:0001977)2.90257852
119positive regulation of cGMP biosynthetic process (GO:0030828)2.87292576
120fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87056682
121glycosylceramide metabolic process (GO:0006677)2.86966741
122regulation of apoptotic cell clearance (GO:2000425)2.86914112
123positive regulation of protein targeting to membrane (GO:0090314)2.86023257
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85960843
125exogenous drug catabolic process (GO:0042738)2.85546564
126regulation of cholesterol homeostasis (GO:2000188)2.83960979
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81726144
128angiotensin maturation (GO:0002003)2.78047102
129regulation of humoral immune response (GO:0002920)2.77874272
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.77277994
131L-phenylalanine catabolic process (GO:0006559)2.77277994
132lipoprotein metabolic process (GO:0042157)2.75438704
133oligosaccharide biosynthetic process (GO:0009312)2.74993390
134blood coagulation, intrinsic pathway (GO:0007597)2.74585152
135nucleoside bisphosphate metabolic process (GO:0033865)2.74467039
136purine nucleoside bisphosphate metabolic process (GO:0034032)2.74467039
137ribonucleoside bisphosphate metabolic process (GO:0033875)2.74467039
138regulation of cGMP metabolic process (GO:0030823)2.74324916
139regulation of systemic arterial blood pressure (GO:0003073)2.74067200
140hypotonic response (GO:0006971)2.73066456
141regulation of early endosome to late endosome transport (GO:2000641)2.72517289
142actin filament depolymerization (GO:0030042)2.71717720
143cholesterol homeostasis (GO:0042632)2.71553050
144transepithelial transport (GO:0070633)2.71446813
145cGMP-mediated signaling (GO:0019934)2.71014000
146sperm capacitation (GO:0048240)2.70944001
147galactose catabolic process (GO:0019388)2.70910322
148negative regulation of blood coagulation (GO:0030195)2.70538517
149negative regulation of hemostasis (GO:1900047)2.70538517
150fucosylation (GO:0036065)2.70504819
151L-fucose catabolic process (GO:0042355)2.70208746
152fucose catabolic process (GO:0019317)2.70208746
153L-fucose metabolic process (GO:0042354)2.70208746
154monocarboxylic acid transport (GO:0015718)2.69816579
155reverse cholesterol transport (GO:0043691)2.69462822
156phenylpropanoid metabolic process (GO:0009698)2.69461486
157sterol homeostasis (GO:0055092)2.69376028
158disruption of cells of other organism (GO:0044364)2.68926569
159killing of cells of other organism (GO:0031640)2.68926569
160transcytosis (GO:0045056)2.68673519
161antigen processing and presentation of endogenous antigen (GO:0019883)2.67541818
162phospholipid homeostasis (GO:0055091)2.66009507
163lipoprotein transport (GO:0042953)2.65706535
164neurotransmitter metabolic process (GO:0042133)2.64445784
165positive regulation of fatty acid oxidation (GO:0046321)2.64401495
166benzene-containing compound metabolic process (GO:0042537)2.63836423
167ethanol metabolic process (GO:0006067)2.63590141
168L-phenylalanine metabolic process (GO:0006558)2.61600581
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61600581
170indolalkylamine metabolic process (GO:0006586)2.61230153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.31386195
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.51607974
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.97910143
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88600827
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.69137248
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64216946
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.30943831
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.14946568
9CDX2_20551321_ChIP-Seq_CACO-2_Human3.09139482
10SOX2_27498859_Chip-Seq_STOMACH_Mouse3.04659982
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.61089196
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58470721
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.52206843
14* SOX2_20726797_ChIP-Seq_SW620_Human2.48468214
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39885242
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22310255
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18782233
18GATA4_25053715_ChIP-Seq_YYC3_Human2.18594675
19GATA6_25053715_ChIP-Seq_YYC3_Human2.17578690
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.14179451
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98637434
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.88256230
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75918009
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75437435
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71324819
26* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69367521
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.68248802
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.67205574
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66132118
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.54836913
31BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.54410470
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54406507
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45662204
34RACK7_27058665_Chip-Seq_MCF-7_Human1.43204141
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.43092385
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40627737
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.40133245
38KLF5_25053715_ChIP-Seq_YYC3_Human1.39984902
39* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36656103
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36093063
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.35500036
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35093224
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32637882
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30618478
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29500388
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28106710
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27406806
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26232850
49CEBPB_22108803_ChIP-Seq_LS180_Human1.26039067
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.25859845
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23597384
52* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22858469
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21966396
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.21658086
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20242129
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18118436
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16581237
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16209510
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14542559
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12379368
61DROSHA_22980978_ChIP-Seq_HELA_Human1.11486426
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09210915
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05547790
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05297723
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05021422
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04665326
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.04480781
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03256419
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03080735
70FOXA1_25552417_ChIP-Seq_VCAP_Human1.02948845
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02497195
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02497195
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02416587
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01096229
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99096305
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98783165
77LXR_22292898_ChIP-Seq_THP-1_Human0.98661748
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98326492
79GATA3_24758297_ChIP-Seq_MCF-7_Human0.98312293
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97682416
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97176590
82* ATF3_27146783_Chip-Seq_COLON_Human0.96366472
83GATA2_19941826_ChIP-Seq_K562_Human0.96231721
84FOXA2_19822575_ChIP-Seq_HepG2_Human0.95695495
85HNF4A_19822575_ChIP-Seq_HepG2_Human0.95589513
86MYC_19915707_ChIP-ChIP_AK7_Human0.95279506
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94604513
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94604513
89RUNX_20019798_ChIP-Seq_JUKART_Human0.94443712
90HTT_18923047_ChIP-ChIP_STHdh_Human0.94034856
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93009889
92* CLOCK_20551151_ChIP-Seq_293T_Human0.92877179
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91938744
94TCF4_18268006_ChIP-ChIP_LS174T_Human0.91212390
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90967150
96CREB1_26743006_Chip-Seq_LNCaP_Human0.90672715
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89026924
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88796076
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88361416
100P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88154524
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86505834
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86369526
103NANOG_20526341_ChIP-Seq_ESCs_Human0.86052142
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85916069
105EGR1_19032775_ChIP-ChIP_M12_Human0.85539726
106AR_21909140_ChIP-Seq_LNCAP_Human0.85341970
107ZNF263_19887448_ChIP-Seq_K562_Human0.85316137
108VDR_24787735_ChIP-Seq_THP-1_Human0.85051053
109RXR_22108803_ChIP-Seq_LS180_Human0.84989400
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84826990
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84778992
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83715947
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83638267
114CDX2_22108803_ChIP-Seq_LS180_Human0.83636706
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.83557239
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82948688
117CTCF_27219007_Chip-Seq_Bcells_Human0.82725324
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81514031
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80780557
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80775316
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79253947
122GATA1_19941826_ChIP-Seq_K562_Human0.79164705
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78929111
124FOXH1_21741376_ChIP-Seq_ESCs_Human0.78643032
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77721628
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76732012
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75967549
128STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75681361
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.75626018
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75463571
131BCAT_22108803_ChIP-Seq_LS180_Human0.73389788
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72701678
133SPI1_23127762_ChIP-Seq_K562_Human0.72636002
134BCL6_27268052_Chip-Seq_Bcells_Human0.71803313
135E2F1_20622854_ChIP-Seq_HELA_Human0.71769071
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71047414
137BCOR_27268052_Chip-Seq_Bcells_Human0.70557652
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70453310
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70142350
140GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.68924363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.18068937
2MP0002822_catalepsy6.09142926
3MP0003878_abnormal_ear_physiology4.79171866
4MP0005377_hearing/vestibular/ear_phenot4.79171866
5MP0005360_urolithiasis4.11327275
6MP0008875_abnormal_xenobiotic_pharmacok3.79812399
7MP0002139_abnormal_hepatobiliary_system3.75461713
8MP0005085_abnormal_gallbladder_physiolo3.59297085
9MP0005257_abnormal_intraocular_pressure3.07355342
10MP0005167_abnormal_blood-brain_barrier2.92892807
11MP0003283_abnormal_digestive_organ2.90663212
12MP0001666_abnormal_nutrient_absorption2.81478033
13MP0003191_abnormal_cellular_cholesterol2.77706987
14MP0001873_stomach_inflammation2.60547287
15MP0003195_calcinosis2.55920066
16MP0005365_abnormal_bile_salt2.47818127
17MP0004264_abnormal_extraembryonic_tissu2.38959821
18MP0003866_abnormal_defecation2.25520560
19MP0003252_abnormal_bile_duct2.13530008
20MP0001663_abnormal_digestive_system1.93342354
21MP0000462_abnormal_digestive_system1.88071947
22MP0005058_abnormal_lysosome_morphology1.84299830
23MP0010155_abnormal_intestine_physiology1.83603448
24MP0005381_digestive/alimentary_phenotyp1.80882413
25MP0003806_abnormal_nucleotide_metabolis1.78614737
26MP0003183_abnormal_peptide_metabolism1.76177602
27MP0002132_abnormal_respiratory_system1.72751538
28MP0004019_abnormal_vitamin_homeostasis1.72721515
29MP0010329_abnormal_lipoprotein_level1.72309167
30MP0003436_decreased_susceptibility_to1.70401021
31MP0005408_hypopigmentation1.68013494
32MP0003300_gastrointestinal_ulcer1.63656699
33MP0000490_abnormal_crypts_of1.52150448
34MP0003868_abnormal_feces_composition1.46051033
35MP0004147_increased_porphyrin_level1.44298084
36MP0002796_impaired_skin_barrier1.43449826
37MP0005670_abnormal_white_adipose1.36873959
38MP0000566_synostosis1.36284313
39MP0002138_abnormal_hepatobiliary_system1.33786250
40MP0010678_abnormal_skin_adnexa1.33070060
41MP0009643_abnormal_urine_homeostasis1.32749104
42MP0003705_abnormal_hypodermis_morpholog1.28142509
43MP0005409_darkened_coat_color1.26122001
44MP0004185_abnormal_adipocyte_glucose1.24234481
45MP0001790_abnormal_immune_system1.22246038
46MP0005387_immune_system_phenotype1.22246038
47* MP0000477_abnormal_intestine_morphology1.21785345
48MP0001664_abnormal_digestion1.20626782
49MP0002277_abnormal_respiratory_mucosa1.19677366
50MP0003724_increased_susceptibility_to1.19284798
51MP0002118_abnormal_lipid_homeostasis1.19078923
52MP0004947_skin_inflammation1.15262404
53MP0001800_abnormal_humoral_immune1.14295061
54MP0009333_abnormal_splenocyte_physiolog1.13530121
55MP0004782_abnormal_surfactant_physiolog1.13083568
56MP0003941_abnormal_skin_development1.12732889
57MP0003122_maternal_imprinting1.11823602
58MP0002419_abnormal_innate_immunity1.11574883
59MP0001533_abnormal_skeleton_physiology1.08931621
60MP0001765_abnormal_ion_homeostasis1.08377841
61MP0000685_abnormal_immune_system1.06932744
62MP0005166_decreased_susceptibility_to1.04953342
63MP0005310_abnormal_salivary_gland1.02302008
64MP0000013_abnormal_adipose_tissue1.01132526
65MP0003172_abnormal_lysosome_physiology1.00334648
66MP0005636_abnormal_mineral_homeostasis0.99038981
67MP0000609_abnormal_liver_physiology0.97841918
68MP0003453_abnormal_keratinocyte_physiol0.97120663
69MP0010352_gastrointestinal_tract_polyps0.96548159
70MP0005464_abnormal_platelet_physiology0.96469530
71MP0005319_abnormal_enzyme/_coenzyme0.96431019
72MP0000465_gastrointestinal_hemorrhage0.93269474
73MP0003303_peritoneal_inflammation0.92372949
74MP0004043_abnormal_pH_regulation0.91945313
75MP0002166_altered_tumor_susceptibility0.89596346
76MP0009840_abnormal_foam_cell0.89268370
77MP0008872_abnormal_physiological_respon0.89050293
78MP0002060_abnormal_skin_morphology0.88824240
79MP0009384_cardiac_valve_regurgitation0.88724926
80MP0001835_abnormal_antigen_presentation0.86777448
81MP0005076_abnormal_cell_differentiation0.86158409
82MP0005332_abnormal_amino_acid0.84114315
83MP0001216_abnormal_epidermal_layer0.83943910
84MP0005584_abnormal_enzyme/coenzyme_acti0.82657530
85MP0002452_abnormal_antigen_presenting0.82355388
86MP0005000_abnormal_immune_tolerance0.79800423
87MP0002933_joint_inflammation0.79655412
88MP0005164_abnormal_response_to0.79560470
89* MP0002723_abnormal_immune_serum0.78803629
90MP0002098_abnormal_vibrissa_morphology0.78755105
91MP0001849_ear_inflammation0.78674461
92MP0002876_abnormal_thyroid_physiology0.78188092
93MP0005451_abnormal_body_composition0.73534410
94MP0003950_abnormal_plasma_membrane0.72138151
95MP0001764_abnormal_homeostasis0.71797749
96* MP0001819_abnormal_immune_cell0.71381937
97MP0000230_abnormal_systemic_arterial0.71141557
98MP0005501_abnormal_skin_physiology0.70899656
99MP0003567_abnormal_fetal_cardiomyocyte0.70762740
100MP0005083_abnormal_biliary_tract0.70294400
101* MP0002420_abnormal_adaptive_immunity0.69449917
102MP0002089_abnormal_postnatal_growth/wei0.68296261
103MP0000537_abnormal_urethra_morphology0.66767001
104MP0005448_abnormal_energy_balance0.66377753
105MP0003075_altered_response_to0.64459021
106MP0002148_abnormal_hypersensitivity_rea0.62552737
107MP0001756_abnormal_urination0.61926484
108MP0009115_abnormal_fat_cell0.61881017
109MP0001845_abnormal_inflammatory_respons0.61044068
110MP0003953_abnormal_hormone_level0.61036803
111MP0003879_abnormal_hair_cell0.59954361
112MP0000470_abnormal_stomach_morphology0.59183840
113MP0000604_amyloidosis0.58456198
114MP0003045_fibrosis0.57638763
115MP0000538_abnormal_urinary_bladder0.57177292
116MP0002136_abnormal_kidney_physiology0.55579663
117MP0008469_abnormal_protein_level0.55156228
118MP0002006_tumorigenesis0.54597483
119* MP0008873_increased_physiological_sensi0.53834430
120MP0002909_abnormal_adrenal_gland0.52266875
121MP0005666_abnormal_adipose_tissue0.50763315
122MP0000383_abnormal_hair_follicle0.50662022
123MP0009642_abnormal_blood_homeostasis0.49487348
124* MP0005025_abnormal_response_to0.49183838
125* MP0009785_altered_susceptibility_to0.48472676
126MP0009053_abnormal_anal_canal0.46458488
127MP0005023_abnormal_wound_healing0.45910821
128MP0005671_abnormal_response_to0.44287343
129MP0004885_abnormal_endolymph0.44253405
130MP0006082_CNS_inflammation0.44181903
131MP0000377_abnormal_hair_follicle0.43284083
132MP0000467_abnormal_esophagus_morphology0.42878315
133MP0009764_decreased_sensitivity_to0.42042227
134MP0010771_integument_phenotype0.41924420
135MP0002971_abnormal_brown_adipose0.40999344

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.70228946
2Pustule (HP:0200039)5.55474827
3Flat acetabular roof (HP:0003180)5.55040060
4Malnutrition (HP:0004395)5.53777731
5Decreased circulating renin level (HP:0003351)4.92389832
6Prostate neoplasm (HP:0100787)4.86845706
7Abnormality of small intestinal villus morphology (HP:0011472)4.75212321
8Villous atrophy (HP:0011473)4.75212321
9Intrahepatic cholestasis (HP:0001406)4.49708390
10Systemic lupus erythematosus (HP:0002725)4.23959371
11Oligomenorrhea (HP:0000876)4.06722481
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90528532
13Abnormality of the 1st metacarpal (HP:0010009)3.79454523
14Glomerulonephritis (HP:0000099)3.76194339
15Xanthomatosis (HP:0000991)3.75257735
16Hyperlipoproteinemia (HP:0010980)3.63305553
17Hypoalphalipoproteinemia (HP:0003233)3.57625192
18Ileus (HP:0002595)3.48023507
19Abdominal distention (HP:0003270)3.46210148
20Cupped ribs (HP:0000887)3.45513248
21Hyperaldosteronism (HP:0000859)3.45433804
22Hyperactive renin-angiotensin system (HP:0000841)3.39876512
23Abnormality of the distal phalanx of the thumb (HP:0009617)3.36033709
24Abnormal tarsal ossification (HP:0008369)3.35164663
25Alopecia of scalp (HP:0002293)3.34982243
26Abnormality of complement system (HP:0005339)3.33269173
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32944289
28Joint hemorrhage (HP:0005261)3.17503122
29Symphalangism affecting the phalanges of the hand (HP:0009773)3.14741866
30Abnormality of carpal bone ossification (HP:0006257)3.11727142
31Hypolipoproteinemia (HP:0010981)3.04509386
32Vacuolated lymphocytes (HP:0001922)2.96723813
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.95526022
34Hyponatremia (HP:0002902)2.92771821
35Deep venous thrombosis (HP:0002625)2.90573422
36Vascular calcification (HP:0004934)2.87786227
37Eczematoid dermatitis (HP:0000976)2.82741754
38Toxemia of pregnancy (HP:0100603)2.81740963
39Gingival bleeding (HP:0000225)2.79221473
40Hypoglycemic coma (HP:0001325)2.74706164
41Fat malabsorption (HP:0002630)2.70549437
42Abnormality of the common coagulation pathway (HP:0010990)2.70054165
43Abnormality of the 2nd finger (HP:0004100)2.68564947
44Recurrent gram-negative bacterial infections (HP:0005420)2.63614511
45Gastrointestinal infarctions (HP:0005244)2.62265027
46Ventricular tachycardia (HP:0004756)2.61866637
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61140896
48Abnormality of purine metabolism (HP:0004352)2.60321893
49Acanthocytosis (HP:0001927)2.59905736
50Short phalanx of the thumb (HP:0009660)2.58522186
51Orchitis (HP:0100796)2.55153286
52Hypokalemia (HP:0002900)2.54913983
53Hypobetalipoproteinemia (HP:0003563)2.52800487
54Abnormality of the proximal phalanges of the hand (HP:0009834)2.51265765
55Nephritis (HP:0000123)2.51061775
56Pili torti (HP:0003777)2.50060742
57Metabolic alkalosis (HP:0200114)2.48107408
58Abnormality of potassium homeostasis (HP:0011042)2.48093978
59Dehydration (HP:0001944)2.44002111
60Neonatal short-limb short stature (HP:0008921)2.41686662
61Hyperuricemia (HP:0002149)2.40324649
62Increased purine levels (HP:0004368)2.40324649
63Abnormality of fatty-acid metabolism (HP:0004359)2.40099774
64Abnormality of the prostate (HP:0008775)2.39772011
65Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.38955579
66Palpitations (HP:0001962)2.38572665
67Abnormal foot bone ossification (HP:0010675)2.37916843
68Abnormal cartilage morphology (HP:0002763)2.37864216
69Abnormality of the nasal septum (HP:0000419)2.37334036
70Abnormal ossification of hand bones (HP:0005921)2.34533503
71Myositis (HP:0100614)2.34234074
72Dicarboxylic aciduria (HP:0003215)2.33893593
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33893593
74Cardiovascular calcification (HP:0011915)2.33656167
75Spontaneous abortion (HP:0005268)2.33199355
76Cheilitis (HP:0100825)2.32065425
77Abnormal hand bone ossification (HP:0010660)2.31943021
78Esophageal varix (HP:0002040)2.31741593
79Retrobulbar optic neuritis (HP:0100654)2.30066262
80Optic neuritis (HP:0100653)2.30066262
81Flattened epiphyses (HP:0003071)2.25349136
82Absent phalangeal crease (HP:0006109)2.22730476
83Hypercholesterolemia (HP:0003124)2.21193457
84Abnormality of sodium homeostasis (HP:0010931)2.20933678
85Hoarse voice (HP:0001609)2.20429348
86Abnormality of chloride homeostasis (HP:0011422)2.20300998
87Joint swelling (HP:0001386)2.19521998
88Prolonged partial thromboplastin time (HP:0003645)2.19409643
89Conjugated hyperbilirubinemia (HP:0002908)2.19042370
90Epidermoid cyst (HP:0200040)2.18328220
91Abnormality of macrophages (HP:0004311)2.18281143
92Abnormality of the middle phalanges of the toes (HP:0010183)2.17501206
93Hyperkalemia (HP:0002153)2.17068263
94Menorrhagia (HP:0000132)2.15817916
95Chronic diarrhea (HP:0002028)2.14430406
96Complement deficiency (HP:0004431)2.13775231
97Purpura (HP:0000979)2.11156204
98Congenital sensorineural hearing impairment (HP:0008527)2.10945197
99Polygenic inheritance (HP:0010982)2.09667767
100Woolly hair (HP:0002224)2.08447250
101Fragile nails (HP:0001808)2.07586996
102Biliary tract neoplasm (HP:0100574)2.05858394
103Milia (HP:0001056)2.05574798
104Short hallux (HP:0010109)2.05044372
105Generalized aminoaciduria (HP:0002909)2.04914005
106Plantar hyperkeratosis (HP:0007556)2.04796651
107Facial shape deformation (HP:0011334)2.04578924
108Potter facies (HP:0002009)2.04578924
109Congenital ichthyosiform erythroderma (HP:0007431)2.03331434
110Abnormality of sulfur amino acid metabolism (HP:0004339)2.02438677
111Onycholysis (HP:0001806)2.02128081
112Irregular epiphyses (HP:0010582)1.99765583
113Hyperammonemia (HP:0001987)1.99569017
114Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98789225
115Widely patent fontanelles and sutures (HP:0004492)1.98631858
116Arthropathy (HP:0003040)1.95996331
117Glomerulosclerosis (HP:0000096)1.95239565
118Aplasia/hypoplasia of the femur (HP:0005613)1.94980443
119Abnormality of nucleobase metabolism (HP:0010932)1.94814150
120Pulmonary embolism (HP:0002204)1.94422864
121Vertebral clefting (HP:0008428)1.92883392
122Abnormality of the phalanges of the hallux (HP:0010057)1.92223560
123Flat capital femoral epiphysis (HP:0003370)1.91485100
124Short middle phalanx of finger (HP:0005819)1.88898565
125Micronodular cirrhosis (HP:0001413)1.87742764
126Abnormality of vitamin metabolism (HP:0100508)1.87721982
127Hypotension (HP:0002615)1.86444896
128Pigmentary retinal degeneration (HP:0001146)1.86330858
129Focal segmental glomerulosclerosis (HP:0000097)1.85763837
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85361753
131Breech presentation (HP:0001623)1.85342661
132Alkalosis (HP:0001948)1.85259310
133Abnormal biliary tract morphology (HP:0012440)1.85207772
134Small epiphyses (HP:0010585)1.84841439
135Steatorrhea (HP:0002570)1.84165200
136Late onset (HP:0003584)1.83464698
137Hydroxyprolinuria (HP:0003080)1.83418197
138Abnormality of proline metabolism (HP:0010907)1.83418197
139Hyperglycemia (HP:0003074)1.83155157
140Metaphyseal irregularity (HP:0003025)1.82348749
141Thrombophlebitis (HP:0004418)1.82127588
142Abnormality of renin-angiotensin system (HP:0000847)1.81612512
143Aplasia/Hypoplasia of the hallux (HP:0008362)1.81418811
144Vasculitis (HP:0002633)1.81351937
145Rickets (HP:0002748)1.80923928
146Petechiae (HP:0000967)1.80650885
147Proximal tubulopathy (HP:0000114)1.79938493
148Hemorrhage of the eye (HP:0011885)1.78169486
149Rectal prolapse (HP:0002035)1.76013638
150Epiphyseal dysplasia (HP:0002656)1.73429353
151Renal tubular acidosis (HP:0001947)1.70309862
152Hypochromic anemia (HP:0001931)1.69448361
153Abnormality of the vitamin B12 metabolism (HP:0004341)1.69356398
154Abnormality of vitamin B metabolism (HP:0004340)1.67025504
155Pancreatitis (HP:0001733)1.66643797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K24.55127316
2MET4.31482257
3KSR24.04869603
4MAP2K23.79966592
5FRK3.03790452
6FGFR32.68936177
7NME12.28408109
8MST1R11.7292580
9MAP2K11.92563381
10TAOK31.86494351
11RIPK11.83584221
12LMTK21.50585637
13MAP3K11.49697636
14CDK121.34237997
15ERN11.30427666
16MAP4K11.28929284
17PRKG21.25548111
18OXSR11.25155378
19MYLK1.24745469
20MST41.23826837
21EPHA21.23337348
22EPHB21.21920807
23TXK1.18568985
24MAP3K121.12120346
25TESK11.12038526
26BLK1.07841208
27CDK91.06294409
28ZAP701.03895359
29STK241.03318801
30MAP3K81.01378923
31IRAK10.98828645
32IRAK40.94345790
33GRK60.88739202
34EEF2K0.87666648
35RIPK40.87662691
36FGR0.86763460
37MAP3K140.84195406
38RET0.80269228
39EPHB10.80200097
40TGFBR20.78601645
41PRKCQ0.75205248
42MATK0.73854478
43YES10.72698043
44PTK60.72087624
45TAOK10.70998066
46PTK20.70712959
47SYK0.69520626
48FGFR10.65040723
49CSK0.64031063
50TYRO30.58228102
51KDR0.57315615
52RPS6KB20.56919324
53DDR20.56562860
54DMPK0.55560404
55LCK0.54922222
56ADRBK20.54915293
57BCKDK0.53230593
58JAK20.52886422
59WNK10.52389111
60BCR0.51925514
61FGFR40.51569774
62MAP3K60.51475210
63MAPKAPK20.51403277
64PIK3CG0.49910524
65JAK10.48639305
66CSF1R0.47635279
67DYRK1B0.45037566
68SGK10.44567918
69STK100.44271414
70* LYN0.42659525
71PDK20.42370184
72IKBKB0.41808021
73MAP3K110.40254533
74LIMK10.39658285
75FER0.39380115
76TBK10.38102870
77NUAK10.37503993
78SIK10.36950803
79JAK30.36742236
80ACVR1B0.34802716
81CDK30.34655334
82ERBB20.34264808
83EPHA30.33653959
84TRPM70.33323229
85PRKAA10.32498567
86PKN20.31759537
87SIK20.31325562
88TESK20.31223357
89MAPK110.31197865
90SGK4940.30998693
91SGK2230.30998693
92PAK40.30541584
93BMX0.30324344
94AKT30.30213509
95NLK0.30112912
96PRKCD0.29986176
97PDGFRB0.29833477
98CAMK2G0.29788503
99MAP3K30.28489458
100PRKCA0.27486127
101ERBB40.27259804
102BMPR1B0.26095662
103CAMK2B0.26031931
104PDPK10.25797060
105TGFBR10.24134108
106DAPK30.23713863
107IGF1R0.23148269
108FYN0.22672385
109PRKAA20.22624912
110WNK40.22097410
111MAPKAPK50.20152265
112ITK0.20104342
113PRKCI0.19269488
114MAP2K60.18584862
115TTN0.18236377
116IKBKE0.17366515
117* CAMK2D0.17362118
118MELK0.17162582
119PDK10.16411340
120* SRC0.15989618
121PTK2B0.14383875
122ROCK10.14208035
123GRK10.13555927
124PRKACG0.12935402
125STK390.12544150
126AURKB0.11856959
127MAPKAPK30.11337277
128MAPK40.10800675
129FGFR20.10711326
130RPS6KA10.10247010
131MAP3K100.09005690
132MAP3K70.08959917
133TTK0.08699083
134PRKCZ0.08354108
135TYK20.08317411
136MAP2K30.07891783
137CDC42BPA0.07202870

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.54225201
2Mineral absorption_Homo sapiens_hsa049783.61193923
3Bile secretion_Homo sapiens_hsa049762.97149912
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.88537859
5Sulfur relay system_Homo sapiens_hsa041222.48363829
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47314692
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43755171
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33476265
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14591996
10Tryptophan metabolism_Homo sapiens_hsa003802.03386159
11Fat digestion and absorption_Homo sapiens_hsa049752.01642869
12Histidine metabolism_Homo sapiens_hsa003402.01036762
13Butanoate metabolism_Homo sapiens_hsa006501.86582498
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.80744638
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.75751739
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69920088
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68910341
18PPAR signaling pathway_Homo sapiens_hsa033201.65348886
19Fatty acid degradation_Homo sapiens_hsa000711.55127019
20Arginine biosynthesis_Homo sapiens_hsa002201.47503217
21Chemical carcinogenesis_Homo sapiens_hsa052041.45700588
22Nitrogen metabolism_Homo sapiens_hsa009101.44124557
23Caffeine metabolism_Homo sapiens_hsa002321.43921738
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42786838
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41312393
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.37962703
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31587890
28Thyroid cancer_Homo sapiens_hsa052161.29584226
29Glycerolipid metabolism_Homo sapiens_hsa005611.23311447
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22189085
31ABC transporters_Homo sapiens_hsa020101.21808265
32Folate biosynthesis_Homo sapiens_hsa007901.18583853
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15435978
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14162147
35Fatty acid biosynthesis_Homo sapiens_hsa000611.13802539
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.11579440
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10150473
38Phenylalanine metabolism_Homo sapiens_hsa003601.09379364
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08239790
40Complement and coagulation cascades_Homo sapiens_hsa046101.07733746
41Galactose metabolism_Homo sapiens_hsa000521.06595892
42Salivary secretion_Homo sapiens_hsa049701.05334984
43Starch and sucrose metabolism_Homo sapiens_hsa005001.05333480
44Fructose and mannose metabolism_Homo sapiens_hsa000511.04737372
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02809060
46Bladder cancer_Homo sapiens_hsa052191.00407264
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91460830
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90250231
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88976099
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87573047
51Renin-angiotensin system_Homo sapiens_hsa046140.87341061
52beta-Alanine metabolism_Homo sapiens_hsa004100.87053851
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86469091
54Linoleic acid metabolism_Homo sapiens_hsa005910.84346037
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82560599
56Tight junction_Homo sapiens_hsa045300.81623787
57Fatty acid metabolism_Homo sapiens_hsa012120.81272214
58Staphylococcus aureus infection_Homo sapiens_hsa051500.77437943
59Retinol metabolism_Homo sapiens_hsa008300.77214972
60Graft-versus-host disease_Homo sapiens_hsa053320.75407027
61Propanoate metabolism_Homo sapiens_hsa006400.73647539
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72590944
63Peroxisome_Homo sapiens_hsa041460.72136170
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.69315902
65Hepatitis C_Homo sapiens_hsa051600.68752910
66Pancreatic secretion_Homo sapiens_hsa049720.66740380
67Glutathione metabolism_Homo sapiens_hsa004800.66682760
68Tyrosine metabolism_Homo sapiens_hsa003500.65311621
69Ether lipid metabolism_Homo sapiens_hsa005650.64199922
70African trypanosomiasis_Homo sapiens_hsa051430.63619049
71Allograft rejection_Homo sapiens_hsa053300.63079038
72Vitamin digestion and absorption_Homo sapiens_hsa049770.62789190
73Salmonella infection_Homo sapiens_hsa051320.62571321
74Autoimmune thyroid disease_Homo sapiens_hsa053200.60413403
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59766253
76Pyruvate metabolism_Homo sapiens_hsa006200.58459607
77Prion diseases_Homo sapiens_hsa050200.56783745
78Oxidative phosphorylation_Homo sapiens_hsa001900.56360697
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.55611514
80Pentose phosphate pathway_Homo sapiens_hsa000300.54849930
81Asthma_Homo sapiens_hsa053100.54236900
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54191891
83Alzheimers disease_Homo sapiens_hsa050100.52914418
84Hematopoietic cell lineage_Homo sapiens_hsa046400.52130246
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.51907945
86Pertussis_Homo sapiens_hsa051330.51834547
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51402666
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49886730
89Type I diabetes mellitus_Homo sapiens_hsa049400.49337915
90Carbon metabolism_Homo sapiens_hsa012000.48065690
91Other glycan degradation_Homo sapiens_hsa005110.47375695
92Leishmaniasis_Homo sapiens_hsa051400.46691830
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.46439083
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.46175193
95Insulin resistance_Homo sapiens_hsa049310.45884171
96Arginine and proline metabolism_Homo sapiens_hsa003300.44910908
97Antigen processing and presentation_Homo sapiens_hsa046120.44741266
98Protein digestion and absorption_Homo sapiens_hsa049740.44181017
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.42065079
100Dorso-ventral axis formation_Homo sapiens_hsa043200.40414258
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.40335564
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39730756
103Adherens junction_Homo sapiens_hsa045200.38658223
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38419217
105Selenocompound metabolism_Homo sapiens_hsa004500.35882057
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35204782
107Thyroid hormone synthesis_Homo sapiens_hsa049180.33284024
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32639477
109Metabolic pathways_Homo sapiens_hsa011000.31910926
110Type II diabetes mellitus_Homo sapiens_hsa049300.29542596
111Parkinsons disease_Homo sapiens_hsa050120.29010620
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.27196904
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27192258
114Fatty acid elongation_Homo sapiens_hsa000620.26314571
115Arachidonic acid metabolism_Homo sapiens_hsa005900.25479616
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24511184
117Sphingolipid metabolism_Homo sapiens_hsa006000.24479369
118Osteoclast differentiation_Homo sapiens_hsa043800.23679501
119Tuberculosis_Homo sapiens_hsa051520.22540410
120Lysosome_Homo sapiens_hsa041420.22068833
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21962377
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21542535
123N-Glycan biosynthesis_Homo sapiens_hsa005100.21446093
124TNF signaling pathway_Homo sapiens_hsa046680.21055521
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20868841
126Amoebiasis_Homo sapiens_hsa051460.16559895
127Toxoplasmosis_Homo sapiens_hsa051450.14405291

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