CEACAM16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.41343911
2B cell receptor signaling pathway (GO:0050853)6.24153927
3positive regulation of gamma-delta T cell activation (GO:0046645)5.97506243
4regulation of B cell receptor signaling pathway (GO:0050855)5.92915581
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41568789
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41568789
7regulation of B cell differentiation (GO:0045577)4.70924632
8positive regulation by symbiont of host defense response (GO:0052509)4.50640237
9modulation by symbiont of host defense response (GO:0052031)4.50640237
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.50640237
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.50640237
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.50640237
13modulation by symbiont of host immune response (GO:0052553)4.50640237
14regulation of interferon-beta biosynthetic process (GO:0045357)4.49957386
15negative regulation of cell killing (GO:0031342)4.48075279
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.48075279
17positive regulation of B cell differentiation (GO:0045579)4.40987020
18positive thymic T cell selection (GO:0045059)4.34882141
19regulation of gamma-delta T cell differentiation (GO:0045586)4.17050416
20regulation of gamma-delta T cell activation (GO:0046643)4.12406172
21leukocyte aggregation (GO:0070486)3.97699455
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.82332536
23respiratory burst (GO:0045730)3.80223154
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.76883535
25immunoglobulin mediated immune response (GO:0016064)3.75043610
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68651075
27B cell proliferation (GO:0042100)3.66511732
28mature B cell differentiation (GO:0002335)3.63750209
29response to interleukin-15 (GO:0070672)3.59663162
30NIK/NF-kappaB signaling (GO:0038061)3.57534233
31macrophage activation involved in immune response (GO:0002281)3.54026483
32positive regulation of antigen processing and presentation (GO:0002579)3.48627706
33positive regulation of interferon-alpha production (GO:0032727)3.41095158
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.39511851
35negative regulation of B cell proliferation (GO:0030889)3.38558146
36cellular response to interleukin-15 (GO:0071350)3.38547398
37B cell homeostasis (GO:0001782)3.38021079
38cellular response to zinc ion (GO:0071294)3.37585819
39thymic T cell selection (GO:0045061)3.36523822
40negative thymic T cell selection (GO:0045060)3.36113097
41response to peptidoglycan (GO:0032494)3.35505961
42antigen receptor-mediated signaling pathway (GO:0050851)3.30714557
43cellular extravasation (GO:0045123)3.30184921
44regulation of interferon-alpha production (GO:0032647)3.26547338
45defense response to protozoan (GO:0042832)3.26181614
46negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.25295513
47response to muramyl dipeptide (GO:0032495)3.22896729
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22800275
49negative regulation of phagocytosis (GO:0050765)3.19243055
50neutrophil activation (GO:0042119)3.16646493
51neutrophil activation involved in immune response (GO:0002283)3.15640013
52T cell migration (GO:0072678)3.15116624
53negative T cell selection (GO:0043383)3.14997063
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13756659
55regulation of B cell proliferation (GO:0030888)3.12002999
56lymphocyte homeostasis (GO:0002260)3.10717214
57positive T cell selection (GO:0043368)3.10693795
58immune response-activating cell surface receptor signaling pathway (GO:0002429)3.07250233
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06047071
60germinal center formation (GO:0002467)3.05830534
61interferon-gamma-mediated signaling pathway (GO:0060333)3.00888179
62response to protozoan (GO:0001562)3.00061003
63T cell selection (GO:0045058)2.98012125
64regulation of B cell apoptotic process (GO:0002902)2.97513256
65negative regulation of interleukin-12 production (GO:0032695)2.96761968
66I-kappaB phosphorylation (GO:0007252)2.96286315
67granulocyte activation (GO:0036230)2.95846443
68tolerance induction (GO:0002507)2.94644667
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94061616
70positive regulation of histone deacetylation (GO:0031065)2.93833246
71T cell homeostasis (GO:0043029)2.93686276
72leukocyte cell-cell adhesion (GO:0007159)2.90917441
73B cell mediated immunity (GO:0019724)2.90599085
74response to host immune response (GO:0052572)2.88059280
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88059280
76negative regulation of histone methylation (GO:0031061)2.85509868
77regulation of mast cell degranulation (GO:0043304)2.85357593
78regulation of antigen processing and presentation (GO:0002577)2.84957087
79positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.83211698
80neutrophil mediated immunity (GO:0002446)2.82998988
81mononuclear cell proliferation (GO:0032943)2.80829690
82natural killer cell mediated immunity (GO:0002228)2.79611180
83natural killer cell mediated cytotoxicity (GO:0042267)2.79611180
84regulation of alpha-beta T cell proliferation (GO:0046640)2.79583010
85positive regulation of mast cell activation involved in immune response (GO:0033008)2.77616011
86positive regulation of mast cell degranulation (GO:0043306)2.77616011
87lymphocyte proliferation (GO:0046651)2.75858679
88positive regulation of mast cell activation (GO:0033005)2.75628421
89positive regulation of Rap GTPase activity (GO:0032854)2.73781064
90Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.72593680
91immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.72593680
92Fc-gamma receptor signaling pathway (GO:0038094)2.72593680
93Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.72011033
94myeloid cell activation involved in immune response (GO:0002275)2.71734481
95negative regulation of toll-like receptor signaling pathway (GO:0034122)2.70815244
96positive regulation of B cell activation (GO:0050871)2.68062146
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67729025
98response to host (GO:0075136)2.67729025
99response to host defenses (GO:0052200)2.67729025
100positive regulation of B cell proliferation (GO:0030890)2.64454989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.22445585
2E2F7_22180533_ChIP-Seq_HELA_Human4.58977110
3MYC_22102868_ChIP-Seq_BL_Human4.12654194
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.98578890
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.76884901
6VDR_21846776_ChIP-Seq_THP-1_Human3.59109448
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48124076
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42211441
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41009092
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26147723
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.22271754
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.09518638
13* IRF8_27001747_Chip-Seq_BMDM_Mouse3.04941074
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83806189
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74115613
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64755248
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59146839
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.54289688
19MAF_26560356_Chip-Seq_TH1_Human2.51055109
20VDR_24763502_ChIP-Seq_THP-1_Human2.41296806
21MYB_26560356_Chip-Seq_TH2_Human2.34220892
22UTX_26944678_Chip-Seq_JUKART_Human2.32206620
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30370806
24* TCF7_22412390_ChIP-Seq_EML_Mouse2.29191444
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28231070
26SPI1_23547873_ChIP-Seq_NB4_Human2.26731502
27MYB_26560356_Chip-Seq_TH1_Human2.26283182
28* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24158954
29RUNX_20019798_ChIP-Seq_JUKART_Human2.16078447
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.13874800
31SCL_19346495_ChIP-Seq_HPC-7_Human2.12546871
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10391975
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08278860
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.06552975
35BP1_19119308_ChIP-ChIP_Hs578T_Human2.05850668
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02881022
37SPI1_23127762_ChIP-Seq_K562_Human1.95754914
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94114496
39KDM2B_26808549_Chip-Seq_DND41_Human1.92902319
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92006323
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91513868
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83099411
43CIITA_25753668_ChIP-Seq_RAJI_Human1.74907169
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74590479
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74524880
46MAF_26560356_Chip-Seq_TH2_Human1.68830433
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.59988091
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50533419
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43872611
50GATA3_27048872_Chip-Seq_THYMUS_Human1.42325742
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41692151
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41138578
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41012558
54* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38744385
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38159090
56PU_27001747_Chip-Seq_BMDM_Mouse1.34810554
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31282495
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31191764
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28706011
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27779738
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27578198
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22962725
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21192580
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18252266
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.13851131
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10421771
67LXR_22292898_ChIP-Seq_THP-1_Human1.10353092
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10053986
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.08856655
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06384873
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06335145
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05894609
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.03902033
74NCOR1_26117541_ChIP-Seq_K562_Human1.03106788
75GATA3_26560356_Chip-Seq_TH2_Human1.00028783
76TFEB_21752829_ChIP-Seq_HELA_Human0.99965884
77GATA1_22025678_ChIP-Seq_K562_Human0.99514279
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97812150
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97017201
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97012012
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96666417
82KDM5A_27292631_Chip-Seq_BREAST_Human0.94100954
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93265611
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.89759828
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87170951
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87054554
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86989364
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85133320
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80701828
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80568209
91SPI1_20517297_ChIP-Seq_HL60_Human0.79992015
92* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79959409
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78375578
94VDR_24787735_ChIP-Seq_THP-1_Human0.78073310
95BCOR_27268052_Chip-Seq_Bcells_Human0.77930396
96BCL6_27268052_Chip-Seq_Bcells_Human0.77606464
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77286573
98P300_27268052_Chip-Seq_Bcells_Human0.75942539
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75936846
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75532121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.79827547
2MP0003303_peritoneal_inflammation4.38446032
3MP0001800_abnormal_humoral_immune3.98713087
4MP0001790_abnormal_immune_system3.93100389
5MP0005387_immune_system_phenotype3.93100389
6MP0000685_abnormal_immune_system3.33780236
7MP0002452_abnormal_antigen_presenting3.26542128
8MP0005000_abnormal_immune_tolerance3.10777316
9MP0002723_abnormal_immune_serum2.85344569
10MP0005671_abnormal_response_to2.82879122
11MP0002420_abnormal_adaptive_immunity2.80969155
12MP0001819_abnormal_immune_cell2.74473175
13MP0003436_decreased_susceptibility_to2.59536639
14MP0002398_abnormal_bone_marrow2.57793822
15MP0002419_abnormal_innate_immunity2.50021996
16MP0004510_myositis2.44600675
17MP0003300_gastrointestinal_ulcer2.42804073
18MP0005025_abnormal_response_to2.37112789
19MP0000716_abnormal_immune_system2.34782089
20MP0000689_abnormal_spleen_morphology2.23769070
21MP0009785_altered_susceptibility_to2.21560537
22MP0001873_stomach_inflammation2.09336910
23MP0003763_abnormal_thymus_physiology2.07035170
24MP0005464_abnormal_platelet_physiology2.04922024
25MP0002722_abnormal_immune_system2.00453013
26MP0002405_respiratory_system_inflammati1.98963190
27MP0003183_abnormal_peptide_metabolism1.98753577
28MP0000569_abnormal_digit_pigmentation1.98744730
29MP0009278_abnormal_bone_marrow1.96782695
30MP0002429_abnormal_blood_cell1.95361319
31MP0002148_abnormal_hypersensitivity_rea1.87355672
32MP0004808_abnormal_hematopoietic_stem1.78152658
33MP0004947_skin_inflammation1.76387049
34MP0001845_abnormal_inflammatory_respons1.75063857
35MP0002396_abnormal_hematopoietic_system1.73134365
36MP0003172_abnormal_lysosome_physiology1.72843029
37MP0010307_abnormal_tumor_latency1.62997731
38MP0009333_abnormal_splenocyte_physiolog1.61037797
39MP0002166_altered_tumor_susceptibility1.59745375
40MP0010155_abnormal_intestine_physiology1.57889618
41MP0005310_abnormal_salivary_gland1.57169984
42MP0001853_heart_inflammation1.56097021
43MP0005174_abnormal_tail_pigmentation1.54622903
44MP0000465_gastrointestinal_hemorrhage1.53962586
45MP0000703_abnormal_thymus_morphology1.48189167
46MP0005058_abnormal_lysosome_morphology1.45175020
47MP0006082_CNS_inflammation1.44571375
48MP0005076_abnormal_cell_differentiation1.40042796
49MP0010352_gastrointestinal_tract_polyps1.32038448
50MP0008057_abnormal_DNA_replication1.31809043
51MP0001545_abnormal_hematopoietic_system1.29452988
52MP0005397_hematopoietic_system_phenotyp1.29452988
53MP0003448_altered_tumor_morphology1.22910641
54MP0008469_abnormal_protein_level1.14561969
55MP0002006_tumorigenesis1.14191573
56MP0001533_abnormal_skeleton_physiology1.07795928
57MP0009840_abnormal_foam_cell1.07689046
58MP0003566_abnormal_cell_adhesion1.07232091
59MP0003866_abnormal_defecation1.06692976
60MP0003077_abnormal_cell_cycle1.04653544
61MP0002933_joint_inflammation1.04317371
62MP0003693_abnormal_embryo_hatching1.01552505
63MP0002019_abnormal_tumor_incidence0.97531512
64MP0000015_abnormal_ear_pigmentation0.97208017
65MP0010234_abnormal_vibrissa_follicle0.95968070
66MP0003111_abnormal_nucleus_morphology0.95009580
67MP0003191_abnormal_cellular_cholesterol0.94638496
68MP0003091_abnormal_cell_migration0.88964357
69MP0000858_altered_metastatic_potential0.87850207
70MP0008961_abnormal_basal_metabolism0.87230388
71MP0000604_amyloidosis0.86990835
72MP0010094_abnormal_chromosome_stability0.82855627
73MP0000490_abnormal_crypts_of0.82759581
74MP0001851_eye_inflammation0.79216140
75MP0009764_decreased_sensitivity_to0.76083432
76MP0002136_abnormal_kidney_physiology0.73055079
77MP0005621_abnormal_cell_physiology0.72406257
78MP0008260_abnormal_autophagy0.71803983
79MP0005166_decreased_susceptibility_to0.69971396
80MP0000350_abnormal_cell_proliferation0.69031587
81MP0003045_fibrosis0.67296760
82MP0001663_abnormal_digestive_system0.67218203
83MP0003453_abnormal_keratinocyte_physiol0.66857182
84MP0000371_diluted_coat_color0.65665386
85MP0008874_decreased_physiological_sensi0.64653792
86MP0005023_abnormal_wound_healing0.63687666
87MP0000313_abnormal_cell_death0.62624364
88MP0002928_abnormal_bile_duct0.61602181
89MP0000343_altered_response_to0.58088781
90MP0002877_abnormal_melanocyte_morpholog0.57285346
91MP0000249_abnormal_blood_vessel0.56569528
92MP0002998_abnormal_bone_remodeling0.56405696
93MP0009763_increased_sensitivity_to0.56024659
94MP0001986_abnormal_taste_sensitivity0.50524849
95MP0005384_cellular_phenotype0.50386749
96MP0002095_abnormal_skin_pigmentation0.49671356
97MP0000733_abnormal_muscle_development0.46013387
98MP0001730_embryonic_growth_arrest0.45772751
99MP0003828_pulmonary_edema0.45648712
100MP0004957_abnormal_blastocyst_morpholog0.45346902

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.83577595
2Recurrent abscess formation (HP:0002722)5.34243758
3Gastrointestinal stroma tumor (HP:0100723)5.18314602
4Eczematoid dermatitis (HP:0000976)5.08045343
5Cellulitis (HP:0100658)5.03722388
6Recurrent bacterial skin infections (HP:0005406)4.93037883
7Colitis (HP:0002583)4.75446556
8Inflammation of the large intestine (HP:0002037)4.42116124
9Recurrent bronchitis (HP:0002837)4.37939836
10Recurrent viral infections (HP:0004429)4.37816190
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.33611646
12IgM deficiency (HP:0002850)4.28276252
13Gastrointestinal inflammation (HP:0004386)4.27939510
14Recurrent fungal infections (HP:0002841)4.17309242
15Meningitis (HP:0001287)4.07934703
16Chronic otitis media (HP:0000389)3.90755837
17Mediastinal lymphadenopathy (HP:0100721)3.85061877
18Recurrent sinusitis (HP:0011108)3.80221562
19Recurrent cutaneous fungal infections (HP:0011370)3.79313806
20Chronic mucocutaneous candidiasis (HP:0002728)3.79313806
21Vasculitis (HP:0002633)3.72145334
22Papilloma (HP:0012740)3.70698310
23Verrucae (HP:0200043)3.70698310
24Emphysema (HP:0002097)3.69973135
25Recurrent skin infections (HP:0001581)3.68541581
26Lymphopenia (HP:0001888)3.65849709
27Recurrent gram-negative bacterial infections (HP:0005420)3.63539816
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.56627060
29Panhypogammaglobulinemia (HP:0003139)3.50915940
30Obstructive lung disease (HP:0006536)3.45742284
31Chronic obstructive pulmonary disease (HP:0006510)3.45742284
32Osteomyelitis (HP:0002754)3.33473158
33Autoimmune thrombocytopenia (HP:0001973)3.29599169
34Restrictive lung disease (HP:0002091)3.15689127
35Abnormality of the fingertips (HP:0001211)3.15342168
36Abnormality of macrophages (HP:0004311)3.13760343
37Chronic sinusitis (HP:0011109)3.04101524
38IgA deficiency (HP:0002720)3.03101306
39Pustule (HP:0200039)2.95180109
40Recurrent pneumonia (HP:0006532)2.90260478
41Recurrent lower respiratory tract infections (HP:0002783)2.85210065
42Nasal polyposis (HP:0100582)2.84000792
43Myositis (HP:0100614)2.75594249
44Elevated erythrocyte sedimentation rate (HP:0003565)2.69712678
45Interstitial pulmonary disease (HP:0006530)2.65987325
46Gingivitis (HP:0000230)2.63877997
47Sepsis (HP:0100806)2.58534456
48Abnormality of T cell physiology (HP:0011840)2.52913650
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.52694440
50Abnormality of T cells (HP:0002843)2.50543539
51Stomatitis (HP:0010280)2.49115617
52Thrombocytosis (HP:0001894)2.43539717
53Leukopenia (HP:0001882)2.43387390
54Increased IgE level (HP:0003212)2.40630844
55B lymphocytopenia (HP:0010976)2.39850898
56Abnormality of B cell number (HP:0010975)2.39850898
57Thyroiditis (HP:0100646)2.37053258
58Recurrent otitis media (HP:0000403)2.36752990
59Abnormality of the nasal mucosa (HP:0000433)2.35674843
60T lymphocytopenia (HP:0005403)2.34223779
61Bronchitis (HP:0012387)2.33884564
62Spontaneous hematomas (HP:0007420)2.33664849
63Abnormality of T cell number (HP:0011839)2.31100347
64Papilledema (HP:0001085)2.26084240
65Hematochezia (HP:0002573)2.24990076
66Myocardial infarction (HP:0001658)2.24202329
67Lymphoma (HP:0002665)2.23337377
68Urticaria (HP:0001025)2.22832713
69Chest pain (HP:0100749)2.22627854
70Encephalitis (HP:0002383)2.19929532
71Skin ulcer (HP:0200042)2.19811218
72Pulmonary infiltrates (HP:0002113)2.17707117
73Periodontitis (HP:0000704)2.17437374
74Viral hepatitis (HP:0006562)2.16279144
75Small epiphyses (HP:0010585)2.13396461
76Prolonged bleeding time (HP:0003010)2.09399652
77Arterial thrombosis (HP:0004420)2.09280291
78Gingival bleeding (HP:0000225)2.08104609
79Leukocytosis (HP:0001974)2.02022551
80Chronic diarrhea (HP:0002028)2.01826929
81Arthralgia (HP:0002829)1.97614600
82Increased cerebral lipofuscin (HP:0011813)1.97246432
83Fatigue (HP:0012378)1.89489425
84Dysostosis multiplex (HP:0000943)1.87963314
85Increased density of long bones (HP:0006392)1.86970334
86Eosinophilia (HP:0001880)1.86755559
87Vacuolated lymphocytes (HP:0001922)1.86265360
88IgG deficiency (HP:0004315)1.85678253
89Mitral stenosis (HP:0001718)1.84913522
90Optic neuritis (HP:0100653)1.83253510
91Retrobulbar optic neuritis (HP:0100654)1.83253510
92Abnormal platelet function (HP:0011869)1.81994996
93Impaired platelet aggregation (HP:0003540)1.81994996
94Petechiae (HP:0000967)1.81447291
95Ulnar bowing (HP:0003031)1.77618461
96Orchitis (HP:0100796)1.77028565
97Abnormal platelet volume (HP:0011876)1.75771602
98Vertebral arch anomaly (HP:0008438)1.74831007
99Granulocytopenia (HP:0001913)1.72794588
100Epistaxis (HP:0000421)1.71153030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.38241129
2SIK22.74213706
3RIPK42.72160688
4BLK2.67632418
5ERN12.62318829
6GRK62.59774848
7MAP3K142.39357380
8TYK22.30705408
9CSF1R2.28915323
10IRAK42.27677030
11MAP3K102.27638215
12STK102.23268638
13BTK2.22019548
14MAP3K132.20098446
15SYK2.18739970
16EEF2K2.02546549
17KIT1.99210554
18JAK11.98041619
19IRAK31.96518040
20LRRK21.92914584
21PKN21.87595060
22FES1.81526429
23TRIB31.77853320
24CDK121.76217956
25TBK11.74847329
26JAK31.65694876
27HCK1.57204928
28CSK1.54592990
29ZAP701.37417138
30ALK1.29865064
31LYN1.27500538
32EPHB11.26264698
33IKBKE1.25906151
34NEK21.25732777
35IKBKB1.24927583
36LCK1.22301402
37ITK1.20341929
38MARK31.20301249
39TAOK31.12061455
40CLK11.02530863
41PIM11.01359284
42CAMK1G0.96950642
43FGR0.95605945
44PRKCH0.95605066
45PTK60.88934035
46BRD40.88268466
47TEC0.84934824
48TTN0.84523616
49CAMK1D0.82052566
50FGFR30.80910758
51CHUK0.79902422
52PRKCQ0.77700510
53MAP2K30.76938853
54MAP3K90.76529739
55TNK20.76066350
56TESK20.66212717
57ABL10.65746377
58JAK20.64893332
59CDK40.63239564
60FGFR40.63059215
61SIK30.62757103
62PDK10.62093327
63STK40.59902501
64MATK0.58112197
65GRK10.54905523
66EGFR0.54643352
67RPS6KA40.53630013
68TXK0.53497652
69MAP3K80.52694149
70TAOK10.50733751
71MAPK40.50150379
72CDK60.49146661
73MST40.48700332
74TGFBR20.47216742
75HIPK20.46434633
76DYRK1B0.45022213
77BMX0.44432101
78FYN0.44304475
79CDC42BPA0.39612685
80SIK10.39108861
81SCYL20.37272099
82CDC70.35405919
83ATR0.30935785
84MAP3K70.30612523
85RPS6KB20.29046573
86MAPKAPK20.28589172
87PAK40.27756552
88INSR0.27440960
89PRKCD0.27329215
90MAP3K110.26658875
91PDPK10.25166300
92MTOR0.25116711
93PDGFRB0.24938450
94RPS6KA60.24683617
95CHEK10.23364543
96MAPK120.22986198
97RPS6KC10.22340237
98RPS6KL10.22340237
99SRC0.19289925
100PRKD20.17141173

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.47797313
2Primary immunodeficiency_Homo sapiens_hsa053403.90155046
3Leishmaniasis_Homo sapiens_hsa051402.63601077
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.52059877
5Osteoclast differentiation_Homo sapiens_hsa043802.47505912
6Hematopoietic cell lineage_Homo sapiens_hsa046402.47362065
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.42337860
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01815564
9Antigen processing and presentation_Homo sapiens_hsa046122.01024968
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.96613749
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.79404440
12T cell receptor signaling pathway_Homo sapiens_hsa046601.78479932
13Tuberculosis_Homo sapiens_hsa051521.75407065
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72045888
15Measles_Homo sapiens_hsa051621.67681955
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66102387
17Chemokine signaling pathway_Homo sapiens_hsa040621.56090422
18Apoptosis_Homo sapiens_hsa042101.45439487
19Shigellosis_Homo sapiens_hsa051311.44299833
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.44071963
21Toxoplasmosis_Homo sapiens_hsa051451.41835834
22Herpes simplex infection_Homo sapiens_hsa051681.40738554
23Influenza A_Homo sapiens_hsa051641.34076283
24Chronic myeloid leukemia_Homo sapiens_hsa052201.34071075
25Acute myeloid leukemia_Homo sapiens_hsa052211.31735058
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31642865
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.30767235
28Viral myocarditis_Homo sapiens_hsa054161.27955552
29Hepatitis B_Homo sapiens_hsa051611.23994728
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.23692215
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22114183
32Epstein-Barr virus infection_Homo sapiens_hsa051691.19022431
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16914324
34Non-small cell lung cancer_Homo sapiens_hsa052231.16475118
35Pancreatic cancer_Homo sapiens_hsa052121.16055096
36TNF signaling pathway_Homo sapiens_hsa046681.14435805
37Malaria_Homo sapiens_hsa051441.14333006
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11054137
39Platelet activation_Homo sapiens_hsa046111.10331223
40Graft-versus-host disease_Homo sapiens_hsa053321.06299578
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05333342
42Asthma_Homo sapiens_hsa053101.04211608
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.03567872
44VEGF signaling pathway_Homo sapiens_hsa043701.02570688
45Legionellosis_Homo sapiens_hsa051341.00210356
46Allograft rejection_Homo sapiens_hsa053300.99710265
47Pertussis_Homo sapiens_hsa051330.99075083
48Staphylococcus aureus infection_Homo sapiens_hsa051500.93577207
49Base excision repair_Homo sapiens_hsa034100.91757332
50Salmonella infection_Homo sapiens_hsa051320.90948612
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89746726
52mTOR signaling pathway_Homo sapiens_hsa041500.89368910
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88694684
54Viral carcinogenesis_Homo sapiens_hsa052030.87962184
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87748707
56Lysosome_Homo sapiens_hsa041420.87298843
57Hepatitis C_Homo sapiens_hsa051600.87157110
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85651317
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84239626
60African trypanosomiasis_Homo sapiens_hsa051430.83854951
61Other glycan degradation_Homo sapiens_hsa005110.79668724
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79361862
63HTLV-I infection_Homo sapiens_hsa051660.77821115
64Small cell lung cancer_Homo sapiens_hsa052220.75214974
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71476555
66Glioma_Homo sapiens_hsa052140.69075731
67DNA replication_Homo sapiens_hsa030300.68872581
68Renal cell carcinoma_Homo sapiens_hsa052110.68618000
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67397606
70p53 signaling pathway_Homo sapiens_hsa041150.66114331
71HIF-1 signaling pathway_Homo sapiens_hsa040660.66048768
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65417733
73MicroRNAs in cancer_Homo sapiens_hsa052060.64358589
74Type II diabetes mellitus_Homo sapiens_hsa049300.64157052
75Colorectal cancer_Homo sapiens_hsa052100.64117404
76Prolactin signaling pathway_Homo sapiens_hsa049170.62165304
77Notch signaling pathway_Homo sapiens_hsa043300.61909113
78Mismatch repair_Homo sapiens_hsa034300.61818065
79Lysine degradation_Homo sapiens_hsa003100.60765540
80Insulin resistance_Homo sapiens_hsa049310.59990704
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.59481537
82Endocytosis_Homo sapiens_hsa041440.59218196
83Phagosome_Homo sapiens_hsa041450.59189830
84MAPK signaling pathway_Homo sapiens_hsa040100.58260054
85Inositol phosphate metabolism_Homo sapiens_hsa005620.53756817
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52846952
87Proteoglycans in cancer_Homo sapiens_hsa052050.50806637
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.48762962
89FoxO signaling pathway_Homo sapiens_hsa040680.47632708
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43268089
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43072413
92Prostate cancer_Homo sapiens_hsa052150.40109462
93Endometrial cancer_Homo sapiens_hsa052130.40016958
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.37931818
95Rheumatoid arthritis_Homo sapiens_hsa053230.37883145
96Spliceosome_Homo sapiens_hsa030400.37741954
97Dorso-ventral axis formation_Homo sapiens_hsa043200.37712194
98Estrogen signaling pathway_Homo sapiens_hsa049150.36010284
99mRNA surveillance pathway_Homo sapiens_hsa030150.35762096
100Type I diabetes mellitus_Homo sapiens_hsa049400.35453268

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