ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	polyketide metabolic process (GO:0030638)	9.80155748
2	doxorubicin metabolic process (GO:0044598)	9.80155748
3	daunorubicin metabolic process (GO:0044597)	9.80155748
4	intestinal absorption (GO:0050892)	6.28865448
5	intestinal cholesterol absorption (GO:0030299)	6.17388310
6	cellular anion homeostasis (GO:0030002)	6.03219815
7	aminoglycoside antibiotic metabolic process (GO:0030647)	6.02543858
8	angiotensin maturation (GO:0002003)	5.96174206
9	regulation of dendritic cell antigen processing and presentation (GO:0002604)	5.93657203
10	sulfate transmembrane transport (GO:1902358)	5.50777435
11	trivalent inorganic anion homeostasis (GO:0072506)	5.06168892
12	phosphate ion homeostasis (GO:0055062)	5.06168892
13	sulfate transport (GO:0008272)	4.83894259
14	detection of molecule of bacterial origin (GO:0032490)	4.80930587
15	regulation of activation of Janus kinase activity (GO:0010533)	4.65940299
16	positive regulation of antigen processing and presentation (GO:0002579)	4.49534174
17	detection of external biotic stimulus (GO:0098581)	4.40312191
18	detection of bacterium (GO:0016045)	4.37437632
19	vitamin A metabolic process (GO:0006776)	4.27193224
20	detection of other organism (GO:0098543)	4.21756424
21	positive regulation of interleukin-1 beta secretion (GO:0050718)	4.07162919
22	peptide catabolic process (GO:0043171)	4.03827012
23	drinking behavior (GO:0042756)	3.97878601
24	regulation of interleukin-1 beta secretion (GO:0050706)	3.97279004
25	dendritic cell chemotaxis (GO:0002407)	3.97180325
26	regulation of T-helper 1 cell differentiation (GO:0045625)	3.97075956
27	muscle atrophy (GO:0014889)	3.96118574
28	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.96010003
29	auditory receptor cell stereocilium organization (GO:0060088)	3.87818821
30	superoxide anion generation (GO:0042554)	3.76775090
31	positive regulation of interleukin-1 secretion (GO:0050716)	3.76678410
32	striated muscle atrophy (GO:0014891)	3.75920540
33	phospholipid efflux (GO:0033700)	3.69965015
34	regulation of antigen processing and presentation (GO:0002577)	3.67415845
35	bicarbonate transport (GO:0015701)	3.58291040
36	energy homeostasis (GO:0097009)	3.57484547
37	dendritic cell migration (GO:0036336)	3.52529312
38	detection of biotic stimulus (GO:0009595)	3.51910139
39	histamine secretion (GO:0001821)	3.36417300
40	regulation of interleukin-1 secretion (GO:0050704)	3.36355757
41	positive regulation of cellular amide metabolic process (GO:0034250)	3.36164878
42	drug catabolic process (GO:0042737)	3.34662365
43	sulfur compound transport (GO:0072348)	3.31847931
44	lateral ventricle development (GO:0021670)	3.28277968
45	regulation of bile acid biosynthetic process (GO:0070857)	3.26715536
46	digestive system process (GO:0022600)	3.24420602
47	maintenance of gastrointestinal epithelium (GO:0030277)	3.24276807
48	positive regulation of T-helper cell differentiation (GO:0045624)	3.17648225
49	vocalization behavior (GO:0071625)	3.17003601
50	positive regulation of interleukin-1 beta production (GO:0032731)	3.15999868
51	virion attachment to host cell (GO:0019062)	3.12734569
52	adhesion of symbiont to host cell (GO:0044650)	3.12734569
53	skeletal muscle adaptation (GO:0043501)	3.12721785
54	negative regulation of mast cell activation (GO:0033004)	3.12572585
55	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.11319173
56	positive regulation of T-helper 1 type immune response (GO:0002827)	3.05064748
57	superoxide metabolic process (GO:0006801)	2.98595530
58	positive regulation of interleukin-1 production (GO:0032732)	2.83019734
59	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.82299468
60	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.82299468
61	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.81635160
62	positive regulation of NF-kappaB import into nucleus (GO:0042346)	2.81329230
63	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.79707332
64	regulation of penile erection (GO:0060405)	2.78771683
65	regulation of neutrophil chemotaxis (GO:0090022)	2.78142554
66	regulation of neutrophil migration (GO:1902622)	2.78142554
67	oligosaccharide catabolic process (GO:0009313)	2.77246022
68	positive regulation of triglyceride lipase activity (GO:0061365)	2.73719078
69	positive regulation of lipoprotein lipase activity (GO:0051006)	2.73719078
70	histamine transport (GO:0051608)	2.69234734
71	flavonoid metabolic process (GO:0009812)	2.68857277
72	positive regulation of granulocyte chemotaxis (GO:0071624)	2.68810905
73	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.68691386
74	cholesterol efflux (GO:0033344)	2.68545503
75	response to prostaglandin E (GO:0034695)	2.66224871
76	adenosine metabolic process (GO:0046085)	2.62877868
77	positive regulation of neutrophil migration (GO:1902624)	2.62055255
78	positive regulation of neutrophil chemotaxis (GO:0090023)	2.62055255
79	regulation of cholesterol esterification (GO:0010872)	2.60929984
80	renal absorption (GO:0070293)	2.60899850
81	positive regulation of interleukin-17 production (GO:0032740)	2.56768750
82	adhesion of symbiont to host (GO:0044406)	2.56617210
83	inner ear receptor stereocilium organization (GO:0060122)	2.54458603
84	cellular response to gamma radiation (GO:0071480)	2.54013739
85	regulation of germinal center formation (GO:0002634)	2.53730437
86	thrombin receptor signaling pathway (GO:0070493)	2.49389761
87	response to hydroperoxide (GO:0033194)	2.46841488
88	sperm capacitation (GO:0048240)	2.46820454
89	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.46573950
90	exogenous drug catabolic process (GO:0042738)	2.45955251
91	positive regulation of heat generation (GO:0031652)	2.45080631
92	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.42533377
93	synapsis (GO:0007129)	2.42305720
94	regulation of fever generation (GO:0031620)	2.41340646
95	positive regulation of interleukin-12 production (GO:0032735)	2.38996541
96	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.38774418
97	regulation of T-helper 1 type immune response (GO:0002825)	2.34761882
98	regulation of granulocyte chemotaxis (GO:0071622)	2.33211760
99	reverse cholesterol transport (GO:0043691)	2.32501431
100	actin filament depolymerization (GO:0030042)	2.31397841

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.11706797
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.98627411
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.73990115
4	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.48404387
5	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.40546200
6	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.36651661
7	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.28923038
8	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.23447340
9	NFE2_27457419_Chip-Seq_LIVER_Mouse	2.12061370
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09276082
11	VDR_22108803_ChIP-Seq_LS180_Human	2.08118420
12	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.07085052
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.03210657
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95477722
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.94555290
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.91283372
17	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.81073686
18	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.72225302
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.71415446
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69798398
21	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.66427396
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.65316098
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.64671030
24	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.64039439
25	P300_19829295_ChIP-Seq_ESCs_Human	1.63453638
26	P53_22387025_ChIP-Seq_ESCs_Mouse	1.62753426
27	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.61759206
28	DROSHA_22980978_ChIP-Seq_HELA_Human	1.61652186
29	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.58706376
30	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.54746977
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51801049
32	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.51211476
33	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.50645922
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.47699445
35	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.46701196
36	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.44901147
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43687384
38	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.42789274
39	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.42764909
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.42329515
41	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.42190911
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.42019016
43	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.41880045
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41695259
45	P300_18555785_Chip-Seq_ESCs_Mouse	1.40876930
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39293311
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.38379881
48	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.36614560
49	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.36424537
50	PU1_27457419_Chip-Seq_LIVER_Mouse	1.34548799
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34310806
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.33594795
53	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.30972714
54	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.30285273
55	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.30202197
56	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.29784939
57	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27716725
58	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.27526388
59	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.27526388
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26963955
61	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26928436
62	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26900979
63	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.25300313
64	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24649842
65	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.23942126
66	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22513287
67	AR_25329375_ChIP-Seq_VCAP_Human	1.22211614
68	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.21789911
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.21400071
70	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.21312567
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20732423
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20552495
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20552495
74	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.18924956
75	IGF1R_20145208_ChIP-Seq_DFB_Human	1.18391722
76	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.18104250
77	SOX2_20726797_ChIP-Seq_SW620_Human	1.18087082
78	KDM2B_26808549_Chip-Seq_REH_Human	1.16118531
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15850233
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.15171404
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14331312
82	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.13886170
83	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13637156
84	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.13018340
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11861533
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10904492
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.09486140
88	* STAT3_23295773_ChIP-Seq_U87_Human	1.08902368
89	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.07778976
90	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06910437
91	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.06354430
92	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.05893113
93	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.04831387
94	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.04815120
95	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02045040
96	RXR_22108803_ChIP-Seq_LS180_Human	1.01937615
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01396649
98	FUS_26573619_Chip-Seq_HEK293_Human	1.00796403
99	STAT1_17558387_ChIP-Seq_HELA_Human	0.98858806
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98735100

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	5.08359737
2	MP0003183_abnormal_peptide_metabolism	4.57748957
3	MP0003878_abnormal_ear_physiology	4.51166847
4	MP0005377_hearing/vestibular/ear_phenot	4.51166847
5	MP0009697_abnormal_copulation	3.78515429
6	MP0002254_reproductive_system_inflammat	3.38897830
7	MP0002876_abnormal_thyroid_physiology	3.32394463
8	MP0001666_abnormal_nutrient_absorption	3.29696712
9	MP0008004_abnormal_stomach_pH	3.18894942
10	MP0000678_abnormal_parathyroid_gland	2.47384669
11	MP0005645_abnormal_hypothalamus_physiol	2.42174138
12	MP0002735_abnormal_chemical_nociception	2.39561966
13	MP0006292_abnormal_olfactory_placode	2.24564703
14	MP0003879_abnormal_hair_cell	2.13958731
15	MP0002277_abnormal_respiratory_mucosa	2.13128759
16	MP0005647_abnormal_sex_gland	2.10019413
17	MP0001188_hyperpigmentation	2.05595130
18	MP0004782_abnormal_surfactant_physiolog	1.99186033
19	MP0002148_abnormal_hypersensitivity_rea	1.97277377
20	MP0001873_stomach_inflammation	1.91267708
21	MP0001346_abnormal_lacrimal_gland	1.84356614
22	MP0005367_renal/urinary_system_phenotyp	1.75244379
23	MP0000516_abnormal_urinary_system	1.75244379
24	MP0004147_increased_porphyrin_level	1.73144255
25	MP0001664_abnormal_digestion	1.71919429
26	MP0004264_abnormal_extraembryonic_tissu	1.68711449
27	MP0009764_decreased_sensitivity_to	1.65765925
28	MP0005310_abnormal_salivary_gland	1.63224788
29	MP0009785_altered_susceptibility_to	1.63212459
30	MP0005171_absent_coat_pigmentation	1.63138848
31	MP0005646_abnormal_pituitary_gland	1.59657003
32	MP0000566_synostosis	1.53455139
33	MP0003866_abnormal_defecation	1.53201355
34	MP0000685_abnormal_immune_system	1.53157704
35	MP0001663_abnormal_digestive_system	1.51922719
36	MP0003252_abnormal_bile_duct	1.50643766
37	MP0000538_abnormal_urinary_bladder	1.49391985
38	MP0002089_abnormal_postnatal_growth/wei	1.42833747
39	MP0001986_abnormal_taste_sensitivity	1.40151070
40	MP0001485_abnormal_pinna_reflex	1.39862318
41	MP0003941_abnormal_skin_development	1.38805279
42	MP0001835_abnormal_antigen_presentation	1.37756650
43	MP0002822_catalepsy	1.31237771
44	MP0005085_abnormal_gallbladder_physiolo	1.29419925
45	MP0010155_abnormal_intestine_physiology	1.29029443
46	MP0005448_abnormal_energy_balance	1.27139061
47	MP0000681_abnormal_thyroid_gland	1.23832313
48	MP0005503_abnormal_tendon_morphology	1.22499870
49	MP0002132_abnormal_respiratory_system	1.20349809
50	MP0001764_abnormal_homeostasis	1.18338570
51	MP0002419_abnormal_innate_immunity	1.17408205
52	MP0010386_abnormal_urinary_bladder	1.15514545
53	MP0002160_abnormal_reproductive_system	1.15366911
54	MP0009840_abnormal_foam_cell	1.15302058
55	MP0005381_digestive/alimentary_phenotyp	1.15020473
56	MP0002163_abnormal_gland_morphology	1.14776130
57	MP0004019_abnormal_vitamin_homeostasis	1.08623176
58	MP0009333_abnormal_splenocyte_physiolog	1.08219632
59	MP0001790_abnormal_immune_system	1.06836745
60	MP0005387_immune_system_phenotype	1.06836745
61	MP0003724_increased_susceptibility_to	1.06396264
62	MP0005084_abnormal_gallbladder_morpholo	1.04525112
63	MP0005025_abnormal_response_to	1.03487612
64	MP0006082_CNS_inflammation	0.99873692
65	MP0000470_abnormal_stomach_morphology	0.99188675
66	MP0000015_abnormal_ear_pigmentation	0.99076120
67	MP0000490_abnormal_crypts_of	0.90591071
68	MP0010329_abnormal_lipoprotein_level	0.90265230
69	MP0003136_yellow_coat_color	0.85922731
70	MP0004742_abnormal_vestibular_system	0.85545931
71	MP0005464_abnormal_platelet_physiology	0.84964785
72	MP0001501_abnormal_sleep_pattern	0.83823067
73	MP0001881_abnormal_mammary_gland	0.82908339
74	MP0004134_abnormal_chest_morphology	0.82275497
75	MP0001502_abnormal_circadian_rhythm	0.81072992
76	MP0001845_abnormal_inflammatory_respons	0.80255598
77	MP0002452_abnormal_antigen_presenting	0.79601367
78	MP0000462_abnormal_digestive_system	0.79409491
79	MP0005671_abnormal_response_to	0.78023048
80	MP0002138_abnormal_hepatobiliary_system	0.76807282
81	MP0002998_abnormal_bone_remodeling	0.76097694
82	MP0002557_abnormal_social/conspecific_i	0.73826534
83	MP0001800_abnormal_humoral_immune	0.70157091
84	MP0004510_myositis	0.68791212
85	MP0005000_abnormal_immune_tolerance	0.66944799
86	MP0002723_abnormal_immune_serum	0.65818012
87	MP0001963_abnormal_hearing_physiology	0.64116576
88	MP0001119_abnormal_female_reproductive	0.64116279
89	MP0001819_abnormal_immune_cell	0.63731783
90	MP0001853_heart_inflammation	0.63006072
91	MP0000026_abnormal_inner_ear	0.62334983
92	MP0002736_abnormal_nociception_after	0.61756665
93	MP0003436_decreased_susceptibility_to	0.59921171
94	MP0005389_reproductive_system_phenotype	0.58533053
95	MP0002420_abnormal_adaptive_immunity	0.58360947
96	MP0004858_abnormal_nervous_system	0.56060692
97	MP0004043_abnormal_pH_regulation	0.55682633
98	MP0005167_abnormal_blood-brain_barrier	0.55571428
99	MP0005166_decreased_susceptibility_to	0.55163766
100	MP0006276_abnormal_autonomic_nervous	0.55151678

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cheilitis (HP:0100825)	4.79611269
2	Alopecia of scalp (HP:0002293)	4.51939528
3	Unilateral renal agenesis (HP:0000122)	4.04150698
4	Parakeratosis (HP:0001036)	3.97934010
5	Autoimmune thrombocytopenia (HP:0001973)	3.92169462
6	Hydroxyprolinuria (HP:0003080)	3.80743870
7	Abnormality of proline metabolism (HP:0010907)	3.80743870
8	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.70217193
9	Conjugated hyperbilirubinemia (HP:0002908)	3.50785375
10	Increased IgE level (HP:0003212)	3.45219813
11	Hyperphosphatemia (HP:0002905)	3.37001412
12	Chronic diarrhea (HP:0002028)	3.27209221
13	Abnormality of dental color (HP:0011073)	3.23541025
14	Follicular hyperkeratosis (HP:0007502)	3.21402038
15	Bilateral sensorineural hearing impairment (HP:0008619)	3.18722471
16	Eczematoid dermatitis (HP:0000976)	3.13745707
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.09303016
18	Absent eyebrow (HP:0002223)	3.09095379
19	Gingivitis (HP:0000230)	3.06500971
20	Recurrent abscess formation (HP:0002722)	2.89948610
21	Congenital sensorineural hearing impairment (HP:0008527)	2.89909583
22	Optic neuritis (HP:0100653)	2.85395386
23	Retrobulbar optic neuritis (HP:0100654)	2.85395386
24	Autoimmune hemolytic anemia (HP:0001890)	2.80254879
25	Orchitis (HP:0100796)	2.78099614
26	Chromsome breakage (HP:0040012)	2.71500476
27	Cupped ribs (HP:0000887)	2.67443322
28	Pigmentary retinal degeneration (HP:0001146)	2.65016113
29	Acanthocytosis (HP:0001927)	2.63494658
30	B lymphocytopenia (HP:0010976)	2.63451252
31	Abnormality of B cell number (HP:0010975)	2.63451252
32	Prostate neoplasm (HP:0100787)	2.58612857
33	Ileus (HP:0002595)	2.58567689
34	Poikilocytosis (HP:0004447)	2.56060266
35	Chronic otitis media (HP:0000389)	2.55204397
36	Patchy hypopigmentation of hair (HP:0011365)	2.55003485
37	Recurrent fungal infections (HP:0002841)	2.54457575
38	Thyroiditis (HP:0100646)	2.51287558
39	Pustule (HP:0200039)	2.51061709
40	White forelock (HP:0002211)	2.49959860
41	Tetany (HP:0001281)	2.46188036
42	Absent eyelashes (HP:0000561)	2.44464301
43	Urticaria (HP:0001025)	2.42682590
44	Keratitis (HP:0000491)	2.39417316
45	Palmoplantar hyperkeratosis (HP:0000972)	2.39114153
46	Recurrent bacterial skin infections (HP:0005406)	2.39062177
47	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.36613394
48	Hypoplasia of the fovea (HP:0007750)	2.36613394
49	Ectropion (HP:0000656)	2.34369187
50	Myositis (HP:0100614)	2.32284336
51	Palmar hyperkeratosis (HP:0010765)	2.27984692
52	Recurrent corneal erosions (HP:0000495)	2.27742196
53	Plantar hyperkeratosis (HP:0007556)	2.27242841
54	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.26450023
55	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.23336272
56	Recurrent pneumonia (HP:0006532)	2.21599104
57	Osteomalacia (HP:0002749)	2.20239798
58	Abnormality of macrophages (HP:0004311)	2.18421402
59	Recurrent cutaneous fungal infections (HP:0011370)	2.13030589
60	Chronic mucocutaneous candidiasis (HP:0002728)	2.13030589
61	Severe combined immunodeficiency (HP:0004430)	2.11943116
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09430055
63	Absent/shortened dynein arms (HP:0200106)	2.09430055
64	Hyperactive renin-angiotensin system (HP:0000841)	2.09030741
65	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.06411607
66	Eosinophilia (HP:0001880)	2.06213577
67	Keratoconjunctivitis (HP:0001096)	2.03397763
68	Increased IgM level (HP:0003496)	2.02985119
69	Type 2 muscle fiber atrophy (HP:0003554)	2.02148070
70	Premature loss of primary teeth (HP:0006323)	2.02068570
71	Abnormality of DNA repair (HP:0003254)	2.00397367
72	Reduced antithrombin III activity (HP:0001976)	1.94984590
73	Alveolar cell carcinoma (HP:0006519)	1.93909810
74	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.93585433
75	Mediastinal lymphadenopathy (HP:0100721)	1.92780774
76	Dehydration (HP:0001944)	1.92659066
77	Widely patent fontanelles and sutures (HP:0004492)	1.92001591
78	Abnormality of eosinophils (HP:0001879)	1.91807078
79	Right ventricular cardiomyopathy (HP:0011663)	1.91591901
80	Septo-optic dysplasia (HP:0100842)	1.91145715
81	Basal ganglia calcification (HP:0002135)	1.90118826
82	Febrile seizures (HP:0002373)	1.88210179
83	Tetraparesis (HP:0002273)	1.87325265
84	Recurrent gram-negative bacterial infections (HP:0005420)	1.85412135
85	Duplicated collecting system (HP:0000081)	1.84692019
86	Hypergammaglobulinemia (HP:0010702)	1.84001230
87	Chronic hepatic failure (HP:0100626)	1.81647215
88	Corneal erosion (HP:0200020)	1.81521466
89	Amelogenesis imperfecta (HP:0000705)	1.80734814
90	Hypobetalipoproteinemia (HP:0003563)	1.80399636
91	Neoplasm of the lung (HP:0100526)	1.79883887
92	Symptomatic seizures (HP:0011145)	1.78321366
93	Abolished electroretinogram (ERG) (HP:0000550)	1.75935736
94	True hermaphroditism (HP:0010459)	1.75697514
95	Chronic obstructive pulmonary disease (HP:0006510)	1.74510505
96	Obstructive lung disease (HP:0006536)	1.74510505
97	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.74441399
98	Aplasia of the musculature (HP:0100854)	1.74419319
99	Periodontitis (HP:0000704)	1.72145978
100	Abnormality of the renal collecting system (HP:0004742)	1.71152853

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK3	5.35422959
2	CASK	3.32854296
3	AKT3	3.15441835
4	FRK	2.82731527
5	PRPF4B	2.74640922
6	MAP3K14	2.67011849
7	MST1R	2.66448728
8	EPHA2	2.65374774
9	TXK	2.64291375
10	MST4	2.47229349
11	STK38L	2.28238356
12	IRAK3	2.11440331
13	IRAK4	2.10936199
14	ERBB3	2.05956410
15	TAOK2	1.98203741
16	BMPR2	1.91268550
17	MARK3	1.87655364
18	SIK2	1.80668163
19	TNIK	1.72751867
20	PRKG2	1.72611702
21	ZAK	1.70170742
22	YES1	1.68893024
23	PIM2	1.56281491
24	ADRBK2	1.38279552
25	LATS1	1.34062621
26	NUAK1	1.31783488
27	SIK1	1.31058238
28	JAK3	1.22687436
29	TNK2	1.20749837
30	RIPK4	1.19810868
31	SGK2	1.16755640
32	LMTK2	1.12234783
33	CDK8	1.09914140
34	EIF2AK2	1.06199808
35	STK24	1.04190484
36	MUSK	1.02627687
37	INSRR	1.00774276
38	NME1	0.99298929
39	DYRK3	0.97519345
40	IKBKE	0.92962389
41	NEK9	0.92126539
42	PINK1	0.91447535
43	MAP3K12	0.85758734
44	MATK	0.82926188
45	GRK1	0.81968922
46	IKBKB	0.80876131
47	ERBB4	0.79892225
48	SGK3	0.76395764
49	CDK3	0.75278506
50	PRKCE	0.74843373
51	SYK	0.73759397
52	TBK1	0.72833471
53	PRKCD	0.68777823
54	CHUK	0.66771085
55	MAP2K7	0.66223438
56	BMPR1B	0.66194411
57	TEC	0.65611215
58	PLK2	0.65118384
59	MAP2K6	0.64463888
60	BTK	0.63150722
61	GRK6	0.61683227
62	TRPM7	0.59358707
63	BRAF	0.58428090
64	MAP4K1	0.57812732
65	LYN	0.56849604
66	TAOK3	0.53876141
67	NTRK3	0.52396739
68	MYLK	0.52223897
69	STK16	0.52150742
70	PRKCQ	0.51350071
71	DYRK1A	0.49936167
72	MAPK13	0.49868138
73	PIM1	0.48990389
74	TYK2	0.44385150
75	MAPK11	0.43710420
76	JAK1	0.42508580
77	BCR	0.42245968
78	MKNK2	0.39463514
79	RPS6KB1	0.38769555
80	FGR	0.35060581
81	PRKCA	0.33721142
82	CSNK1A1	0.33203834
83	OBSCN	0.32588811
84	PRKG1	0.32339718
85	RPS6KL1	0.32099165
86	RPS6KC1	0.32099165
87	EPHA3	0.31742745
88	DDR2	0.30761378
89	MAPK7	0.30018141
90	STK10	0.29961552
91	GRK7	0.29854141
92	ABL1	0.29753367
93	EIF2AK3	0.29383935
94	DYRK1B	0.29101649
95	PAK4	0.28957143
96	RPS6KA6	0.27719751
97	SGK223	0.26810169
98	SGK494	0.26810169
99	PRKAA2	0.25868991
100	STK3	0.25293249

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mineral absorption_Homo sapiens_hsa04978	4.33954168
2	Fat digestion and absorption_Homo sapiens_hsa04975	4.12591879
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	4.02034866
4	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.85757494
5	Renin-angiotensin system_Homo sapiens_hsa04614	3.51522443
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.70748061
7	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.43364224
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.36488980
9	Histidine metabolism_Homo sapiens_hsa00340	2.19035977
10	Galactose metabolism_Homo sapiens_hsa00052	2.04736273
11	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.01261308
12	Sphingolipid metabolism_Homo sapiens_hsa00600	1.97409753
13	Protein digestion and absorption_Homo sapiens_hsa04974	1.81535210
14	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.76015848
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.69897484
16	African trypanosomiasis_Homo sapiens_hsa05143	1.66106468
17	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.62450054
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49993046
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.48283734
20	Caffeine metabolism_Homo sapiens_hsa00232	1.45105574
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.38240669
22	Sulfur metabolism_Homo sapiens_hsa00920	1.35696188
23	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.26140492
24	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.26029170
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.25947357
26	Folate biosynthesis_Homo sapiens_hsa00790	1.24429237
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.21204599
28	ABC transporters_Homo sapiens_hsa02010	1.19934858
29	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.19408533
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15252220
31	Leishmaniasis_Homo sapiens_hsa05140	1.14658800
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14054060
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14020411
34	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.10361056
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.06435889
36	Allograft rejection_Homo sapiens_hsa05330	1.03496609
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02346747
38	Tuberculosis_Homo sapiens_hsa05152	0.98816058
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96699013
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96192833
41	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.90245799
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85959876
43	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.85277742
44	Legionellosis_Homo sapiens_hsa05134	0.82502032
45	Nicotine addiction_Homo sapiens_hsa05033	0.80349678
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.77735448
47	Graft-versus-host disease_Homo sapiens_hsa05332	0.76873150
48	TNF signaling pathway_Homo sapiens_hsa04668	0.76482952
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.76161672
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74038741
51	Influenza A_Homo sapiens_hsa05164	0.72075656
52	Measles_Homo sapiens_hsa05162	0.70561013
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70002291
54	Phagosome_Homo sapiens_hsa04145	0.69170772
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.68049053
56	Other glycan degradation_Homo sapiens_hsa00511	0.64878907
57	Glutathione metabolism_Homo sapiens_hsa00480	0.63759735
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.62926371
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61136515
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60993764
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60779319
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59513257
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58365761
64	Olfactory transduction_Homo sapiens_hsa04740	0.58033525
65	Bile secretion_Homo sapiens_hsa04976	0.56910352
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56592657
67	Arginine biosynthesis_Homo sapiens_hsa00220	0.55682659
68	Asthma_Homo sapiens_hsa05310	0.55552942
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.51141896
70	Salmonella infection_Homo sapiens_hsa05132	0.50538111
71	Homologous recombination_Homo sapiens_hsa03440	0.50246238
72	Pertussis_Homo sapiens_hsa05133	0.49584413
73	Serotonergic synapse_Homo sapiens_hsa04726	0.49318054
74	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.48416525
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.47584788
76	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.47505785
77	Taste transduction_Homo sapiens_hsa04742	0.46011171
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43800034
79	Morphine addiction_Homo sapiens_hsa05032	0.41822718
80	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41745565
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.41711081
82	Herpes simplex infection_Homo sapiens_hsa05168	0.41107721
83	Circadian rhythm_Homo sapiens_hsa04710	0.40219523
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.39249701
85	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39031683
86	Hepatitis C_Homo sapiens_hsa05160	0.37736511
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.37462022
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.37360411
89	Osteoclast differentiation_Homo sapiens_hsa04380	0.36443290
90	Retinol metabolism_Homo sapiens_hsa00830	0.36277565
91	Malaria_Homo sapiens_hsa05144	0.35444084
92	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.34140342
93	Purine metabolism_Homo sapiens_hsa00230	0.33724007
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.33092179
95	Apoptosis_Homo sapiens_hsa04210	0.31071671
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31054456
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.30982902
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.30709012
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30560945
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.30354778

CEACAM18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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