CEACAM21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.01352236
2cytidine metabolic process (GO:0046087)6.01352236
3cytidine catabolic process (GO:0006216)6.01352236
4regulation of B cell receptor signaling pathway (GO:0050855)5.89731349
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.74689497
6positive regulation of gamma-delta T cell activation (GO:0046645)5.54827607
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.49225199
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.40966616
9T cell migration (GO:0072678)5.36690126
10positive thymic T cell selection (GO:0045059)5.32795031
11DNA deamination (GO:0045006)5.22894845
12negative T cell selection (GO:0043383)5.18832125
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.15837769
14cellular response to interleukin-15 (GO:0071350)5.03823876
15negative thymic T cell selection (GO:0045060)4.86769466
16positive T cell selection (GO:0043368)4.85962596
17antigen processing and presentation of endogenous antigen (GO:0019883)4.81553513
18immunoglobulin mediated immune response (GO:0016064)4.79344850
19response to interleukin-15 (GO:0070672)4.77774809
20negative regulation of cell killing (GO:0031342)4.71791409
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.71791409
22Arp2/3 complex-mediated actin nucleation (GO:0034314)4.59485482
23regulation of gamma-delta T cell differentiation (GO:0045586)4.50949556
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49769112
25regulation of B cell differentiation (GO:0045577)4.44655285
26positive regulation of B cell differentiation (GO:0045579)4.35518129
27thymic T cell selection (GO:0045061)4.31491054
28regulation of gamma-delta T cell activation (GO:0046643)4.25517234
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03103963
30T cell selection (GO:0045058)3.96726500
31regulation of alpha-beta T cell proliferation (GO:0046640)3.96609585
32actin nucleation (GO:0045010)3.96069097
33negative regulation of T cell apoptotic process (GO:0070233)3.93759147
34B cell receptor signaling pathway (GO:0050853)3.92432477
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89031292
36B cell mediated immunity (GO:0019724)3.84800355
37regulation of T cell tolerance induction (GO:0002664)3.82496381
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.82212597
39regulation of regulatory T cell differentiation (GO:0045589)3.74352069
40mast cell activation (GO:0045576)3.73969766
41negative regulation of viral genome replication (GO:0045071)3.64374731
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.60050474
43antigen receptor-mediated signaling pathway (GO:0050851)3.57646532
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.57103471
45regulation of T cell mediated cytotoxicity (GO:0001914)3.55237928
46T cell receptor signaling pathway (GO:0050852)3.52650436
47T cell costimulation (GO:0031295)3.49256685
48leukocyte aggregation (GO:0070486)3.48797936
49regulation of natural killer cell mediated immunity (GO:0002715)3.48543744
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.48543744
51lymphocyte migration (GO:0072676)3.47487804
52regulation of T cell chemotaxis (GO:0010819)3.45457178
53positive regulation of T cell chemotaxis (GO:0010820)3.45457178
54lymphocyte costimulation (GO:0031294)3.44941959
55cellular response to type I interferon (GO:0071357)3.44872582
56type I interferon signaling pathway (GO:0060337)3.44872582
57positive regulation of tolerance induction (GO:0002645)3.41351584
58response to type I interferon (GO:0034340)3.41257772
59lymphocyte chemotaxis (GO:0048247)3.39593175
60respiratory burst (GO:0045730)3.39241722
61positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.38823378
62regulation of tolerance induction (GO:0002643)3.38472508
63regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34130246
64negative regulation of leukocyte mediated immunity (GO:0002704)3.31004641
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30785541
66regulation of interleukin-12 biosynthetic process (GO:0045075)3.29266775
67mast cell degranulation (GO:0043303)3.26685082
68mast cell activation involved in immune response (GO:0002279)3.26685082
69neutrophil activation (GO:0042119)3.26064375
70leukocyte degranulation (GO:0043299)3.22558583
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22456504
72response to interferon-beta (GO:0035456)3.21203746
73antigen processing and presentation via MHC class Ib (GO:0002475)3.21077833
74positive regulation of interleukin-8 secretion (GO:2000484)3.19195490
75positive regulation of natural killer cell mediated immunity (GO:0002717)3.18026145
76positive regulation of granulocyte differentiation (GO:0030854)3.17400153
77negative regulation of lymphocyte mediated immunity (GO:0002707)3.17380493
78regulation of activation of Janus kinase activity (GO:0010533)3.17063858
79regulation of T cell receptor signaling pathway (GO:0050856)3.14332447
80granulocyte activation (GO:0036230)3.13883509
81regulation of lymphocyte chemotaxis (GO:1901623)3.13473289
82regulation of isotype switching to IgG isotypes (GO:0048302)3.12116090
83negative regulation of lymphocyte apoptotic process (GO:0070229)3.11636409
84cellular defense response (GO:0006968)3.10940235
85regulation of cell killing (GO:0031341)3.10838967
86interferon-gamma-mediated signaling pathway (GO:0060333)3.10715591
87positive regulation of cell killing (GO:0031343)3.10452681
88detection of bacterium (GO:0016045)3.07100443
89positive regulation of monocyte chemotaxis (GO:0090026)3.04939249
90dendritic cell chemotaxis (GO:0002407)3.01977807
91neutrophil activation involved in immune response (GO:0002283)3.01884114
92positive regulation of lymphocyte migration (GO:2000403)2.99895166
93detection of other organism (GO:0098543)2.99583043
94regulation of interleukin-2 biosynthetic process (GO:0045076)2.99070232
95pyrimidine nucleoside catabolic process (GO:0046135)2.98657147
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.94740184
97positive regulation of calcium-mediated signaling (GO:0050850)2.94657504
98negative regulation of interleukin-12 production (GO:0032695)2.94617758
99NIK/NF-kappaB signaling (GO:0038061)2.92724738
100myeloid cell activation involved in immune response (GO:0002275)2.91774067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.84214341
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.74191901
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.84057496
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.45628993
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.31575432
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.98979170
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71472090
8MYB_26560356_Chip-Seq_TH2_Human3.34532248
9RUNX_20019798_ChIP-Seq_JUKART_Human3.21810794
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96587596
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.96115410
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.91039352
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89115549
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54336693
15MYB_26560356_Chip-Seq_TH1_Human2.44251222
16GATA3_27048872_Chip-Seq_THYMUS_Human2.41655205
17UTX_26944678_Chip-Seq_JUKART_Human2.34294890
18MAF_26560356_Chip-Seq_TH1_Human2.27100735
19* SPI1_23547873_ChIP-Seq_NB4_Human2.26090418
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.25328456
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.24112887
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16898022
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13959020
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08726916
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04945468
26SCL_19346495_ChIP-Seq_HPC-7_Human2.04578522
27MAF_26560356_Chip-Seq_TH2_Human2.01362933
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97570595
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97329600
30GATA3_26560356_Chip-Seq_TH2_Human1.94650073
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93213626
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.73519488
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72609754
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71042862
35VDR_24763502_ChIP-Seq_THP-1_Human1.61092344
36CIITA_25753668_ChIP-Seq_RAJI_Human1.59242904
37* SPI1_23127762_ChIP-Seq_K562_Human1.57126773
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53151775
39BCL6_27268052_Chip-Seq_Bcells_Human1.51946297
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51305905
41MYC_22102868_ChIP-Seq_BL_Human1.42399323
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41815922
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41317552
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34117640
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29784701
46VDR_23849224_ChIP-Seq_CD4+_Human1.27824809
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.26180026
48VDR_21846776_ChIP-Seq_THP-1_Human1.25244649
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24841797
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24363414
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.22565566
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20273022
53* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16203220
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14676068
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14415149
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08751585
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08229027
58BCOR_27268052_Chip-Seq_Bcells_Human1.06998169
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05655285
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05156703
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.04409609
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03078152
63FOXP3_21729870_ChIP-Seq_TREG_Human1.01456579
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01186560
65* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98768361
66SPI1_20517297_ChIP-Seq_HL60_Human0.98482311
67HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97352890
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96818591
69P300_27268052_Chip-Seq_Bcells_Human0.96776801
70VDR_24787735_ChIP-Seq_THP-1_Human0.96388692
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96108614
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93236682
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91270866
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90962880
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89810013
76GATA1_19941827_ChIP-Seq_MEL_Mouse0.89203932
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88998089
78IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88368418
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87880754
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85705930
81GATA1_22025678_ChIP-Seq_K562_Human0.85531047
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84738323
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84350668
84GATA3_26560356_Chip-Seq_TH1_Human0.83673668
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79045573
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78600253
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77252146
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77121062
89SMRT_27268052_Chip-Seq_Bcells_Human0.76881468
90TAF2_19829295_ChIP-Seq_ESCs_Human0.75939766
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75650108
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73457602
93E2F1_20622854_ChIP-Seq_HELA_Human0.72463443
94NANOG_20526341_ChIP-Seq_ESCs_Human0.72148006
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71773966
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71499338
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71340380
98CTCF_20526341_ChIP-Seq_ESCs_Human0.70156131
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.69825148
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69809134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.99776936
2MP0001835_abnormal_antigen_presentation4.40210383
3MP0009785_altered_susceptibility_to3.74194925
4MP0003763_abnormal_thymus_physiology3.50883587
5MP0001800_abnormal_humoral_immune3.41433998
6MP0003724_increased_susceptibility_to3.28631147
7MP0005000_abnormal_immune_tolerance3.28180501
8MP0003436_decreased_susceptibility_to3.18747683
9MP0005025_abnormal_response_to3.07683191
10MP0002723_abnormal_immune_serum2.95265967
11MP0001790_abnormal_immune_system2.93480951
12MP0005387_immune_system_phenotype2.93480951
13MP0000685_abnormal_immune_system2.93265802
14MP0002420_abnormal_adaptive_immunity2.90311836
15MP0001819_abnormal_immune_cell2.85332748
16MP0002148_abnormal_hypersensitivity_rea2.72864257
17MP0002452_abnormal_antigen_presenting2.72043458
18MP0002419_abnormal_innate_immunity2.53812889
19MP0002166_altered_tumor_susceptibility2.49138965
20MP0009333_abnormal_splenocyte_physiolog2.42493512
21MP0002398_abnormal_bone_marrow2.39329788
22MP0002405_respiratory_system_inflammati2.34113167
23MP0000716_abnormal_immune_system2.29268911
24MP0006082_CNS_inflammation2.24259372
25MP0003866_abnormal_defecation2.22775246
26MP0005464_abnormal_platelet_physiology2.16751850
27MP0010155_abnormal_intestine_physiology2.15662378
28MP0000689_abnormal_spleen_morphology1.94615291
29MP0002006_tumorigenesis1.91029938
30MP0002722_abnormal_immune_system1.89912783
31MP0001845_abnormal_inflammatory_respons1.89521492
32MP0000703_abnormal_thymus_morphology1.84230882
33MP0002429_abnormal_blood_cell1.82361978
34MP0001873_stomach_inflammation1.78659160
35MP0002933_joint_inflammation1.65814601
36MP0004947_skin_inflammation1.57188589
37MP0001533_abnormal_skeleton_physiology1.55796194
38MP0003303_peritoneal_inflammation1.48698326
39MP0005310_abnormal_salivary_gland1.48578368
40MP0002138_abnormal_hepatobiliary_system1.45364256
41MP0008469_abnormal_protein_level1.36638245
42MP0000569_abnormal_digit_pigmentation1.33690537
43MP0001853_heart_inflammation1.31397091
44MP0000465_gastrointestinal_hemorrhage1.29000281
45MP0009764_decreased_sensitivity_to1.22796143
46MP0005075_abnormal_melanosome_morpholog1.20755436
47MP0003448_altered_tumor_morphology1.20522691
48MP0009278_abnormal_bone_marrow1.16262018
49MP0003045_fibrosis1.15916146
50MP0003191_abnormal_cellular_cholesterol1.10061710
51MP0002132_abnormal_respiratory_system1.08279464
52MP0003183_abnormal_peptide_metabolism1.04113580
53MP0000858_altered_metastatic_potential1.00760783
54MP0009763_increased_sensitivity_to0.97853075
55MP0008260_abnormal_autophagy0.97737603
56MP0002277_abnormal_respiratory_mucosa0.97413276
57MP0004381_abnormal_hair_follicle0.94333547
58MP0005166_decreased_susceptibility_to0.89932231
59MP0004883_abnormal_blood_vessel0.89052765
60MP0002019_abnormal_tumor_incidence0.87349594
61MP0002396_abnormal_hematopoietic_system0.85287000
62MP0003075_altered_response_to0.83232380
63MP0000604_amyloidosis0.82870476
64MP0002998_abnormal_bone_remodeling0.81971178
65MP0001851_eye_inflammation0.80987633
66MP0003195_calcinosis0.79849256
67MP0003172_abnormal_lysosome_physiology0.78796485
68MP0006054_spinal_hemorrhage0.76935559
69MP0009765_abnormal_xenobiotic_induced0.73891095
70MP0003646_muscle_fatigue0.72491134
71MP0000343_altered_response_to0.70333132
72MP0001663_abnormal_digestive_system0.68570296
73MP0001986_abnormal_taste_sensitivity0.67404799
74MP0005390_skeleton_phenotype0.65661815
75MP0005397_hematopoietic_system_phenotyp0.63528307
76MP0001545_abnormal_hematopoietic_system0.63528307
77MP0002693_abnormal_pancreas_physiology0.61396569
78MP0003300_gastrointestinal_ulcer0.59605965
79MP0001919_abnormal_reproductive_system0.58773868
80MP0004510_myositis0.58129731
81MP0005167_abnormal_blood-brain_barrier0.58027991
82MP0002653_abnormal_ependyma_morphology0.56238167
83MP0005058_abnormal_lysosome_morphology0.56014232
84MP0000015_abnormal_ear_pigmentation0.55525610
85MP0008872_abnormal_physiological_respon0.54458258
86MP0002009_preneoplasia0.53530380
87MP0005645_abnormal_hypothalamus_physiol0.52201966
88MP0005174_abnormal_tail_pigmentation0.51695121
89MP0000249_abnormal_blood_vessel0.51628086
90MP0003795_abnormal_bone_structure0.51517031
91MP0005084_abnormal_gallbladder_morpholo0.50178101
92MP0000490_abnormal_crypts_of0.49754155
93MP0003786_premature_aging0.49200871
94MP0005164_abnormal_response_to0.48368158
95MP0008995_early_reproductive_senescence0.47498884
96MP0002136_abnormal_kidney_physiology0.46854796
97MP0003806_abnormal_nucleotide_metabolis0.46480474
98MP0002095_abnormal_skin_pigmentation0.45613078
99MP0008873_increased_physiological_sensi0.45483305
100MP0005410_abnormal_fertilization0.45399159

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.92473371
2Abnormality of T cell number (HP:0011839)5.58728789
3Stomatitis (HP:0010280)5.06079365
4Elevated erythrocyte sedimentation rate (HP:0003565)4.98398109
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.81365415
6Abnormality of T cells (HP:0002843)4.55977880
7Meningitis (HP:0001287)4.44807909
8Recurrent fungal infections (HP:0002841)4.37869845
9Panhypogammaglobulinemia (HP:0003139)4.37498313
10Agammaglobulinemia (HP:0004432)4.36833810
11IgG deficiency (HP:0004315)4.24558577
12Abnormality of macrophages (HP:0004311)4.12203947
13Recurrent cutaneous fungal infections (HP:0011370)4.07415425
14Chronic mucocutaneous candidiasis (HP:0002728)4.07415425
15Myositis (HP:0100614)4.06299549
16Severe combined immunodeficiency (HP:0004430)4.04452876
17Recurrent abscess formation (HP:0002722)4.03565431
18Aplastic anemia (HP:0001915)4.02875453
19Encephalitis (HP:0002383)3.88770852
20Chronic obstructive pulmonary disease (HP:0006510)3.87151637
21Obstructive lung disease (HP:0006536)3.87151637
22Recurrent viral infections (HP:0004429)3.86143213
23Mediastinal lymphadenopathy (HP:0100721)3.82321039
24Optic neuritis (HP:0100653)3.78685045
25Retrobulbar optic neuritis (HP:0100654)3.78685045
26Autoimmune hemolytic anemia (HP:0001890)3.77421490
27Recurrent bacterial skin infections (HP:0005406)3.68581543
28Increased IgM level (HP:0003496)3.65664635
29Abnormality of B cell number (HP:0010975)3.64513457
30Eczematoid dermatitis (HP:0000976)3.63402141
31Chronic diarrhea (HP:0002028)3.62567097
32Orchitis (HP:0100796)3.57380326
33Pulmonary infiltrates (HP:0002113)3.37222058
34Abnormality of T cell physiology (HP:0011840)3.32927419
35Lymphopenia (HP:0001888)3.32371046
36Abnormality of the prostate (HP:0008775)3.31087141
37Combined immunodeficiency (HP:0005387)3.25710903
38Vasculitis (HP:0002633)3.22989308
39Abnormality of eosinophils (HP:0001879)3.18249360
40Recurrent skin infections (HP:0001581)3.17070392
41Gastrointestinal infarctions (HP:0005244)3.15012440
42Abnormality of cells of the lymphoid lineage (HP:0012140)3.10771599
43IgM deficiency (HP:0002850)3.10754600
44Leukocytosis (HP:0001974)3.10590046
45Recurrent bronchitis (HP:0002837)3.06757290
46Pustule (HP:0200039)3.04630055
47Eosinophilia (HP:0001880)3.04414090
48Thyroiditis (HP:0100646)3.03012496
49B lymphocytopenia (HP:0010976)3.00357995
50Hemoptysis (HP:0002105)2.97352333
51Keratoconjunctivitis sicca (HP:0001097)2.93314630
52Hypoproteinemia (HP:0003075)2.89586011
53Granulocytopenia (HP:0001913)2.88152939
54Chest pain (HP:0100749)2.85564301
55Joint swelling (HP:0001386)2.84705079
56Keratoconjunctivitis (HP:0001096)2.81770729
57Autoimmune thrombocytopenia (HP:0001973)2.78802471
58Spontaneous hematomas (HP:0007420)2.72698241
59Recurrent gram-negative bacterial infections (HP:0005420)2.68683656
60Hypoplasia of the thymus (HP:0000778)2.60319821
61Inflammation of the large intestine (HP:0002037)2.58127105
62Urticaria (HP:0001025)2.55335795
63Gangrene (HP:0100758)2.52631320
64Abnormality of the pleura (HP:0002103)2.52263927
65Pulmonary embolism (HP:0002204)2.49347154
66Hypergammaglobulinemia (HP:0010702)2.45782056
67Gastrointestinal inflammation (HP:0004386)2.45352547
68Stomach cancer (HP:0012126)2.44406249
69Recurrent sinusitis (HP:0011108)2.35786467
70Sepsis (HP:0100806)2.30273731
71Epistaxis (HP:0000421)2.29875293
72Bronchitis (HP:0012387)2.26278382
73Pulmonary fibrosis (HP:0002206)2.26057081
74Lymphoma (HP:0002665)2.24761562
75Increased IgE level (HP:0003212)2.24658044
76Abnormality of male internal genitalia (HP:0000022)2.19487132
77Polyneuropathy (HP:0001271)2.18393179
783-Methylglutaconic aciduria (HP:0003535)2.17073108
79Prolonged bleeding time (HP:0003010)2.15578476
80Skin rash (HP:0000988)2.14354080
81Arterial thrombosis (HP:0004420)2.13695303
82Hematochezia (HP:0002573)2.11275819
83Anorexia (HP:0002039)2.10844668
84Cellulitis (HP:0100658)2.10833446
85Acute hepatic failure (HP:0006554)2.06165529
86Colitis (HP:0002583)2.02642983
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00831926
88Gingivitis (HP:0000230)1.97608848
89IgA deficiency (HP:0002720)1.94391092
90Congenital stationary night blindness (HP:0007642)1.93071196
91Hypochromic anemia (HP:0001931)1.91495364
92Episodic fever (HP:0001954)1.88493001
93Papilloma (HP:0012740)1.88358038
94Verrucae (HP:0200043)1.88358038
95Gingival bleeding (HP:0000225)1.87444191
96Petechiae (HP:0000967)1.87272834
97Hepatosplenomegaly (HP:0001433)1.81106433
98Microcytic anemia (HP:0001935)1.80907960
99Recurrent otitis media (HP:0000403)1.78424199
100Ureteral obstruction (HP:0006000)1.78362151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.34954667
2MAP4K14.28404985
3KDR3.64700717
4TESK23.43446555
5ITK2.85719673
6FES2.84657837
7TAOK32.75759396
8SYK2.61389441
9RIPK42.51347641
10GRK62.42696175
11CSK2.18939303
12IKBKE2.14057599
13BTK2.07486865
14ZAP702.02820744
15KIT1.96499461
16TEC1.90754189
17BLK1.90352288
18TYK21.84320459
19JAK31.79452605
20BCKDK1.78686991
21LCK1.74399115
22IRAK41.68367445
23LYN1.62126190
24CSF1R1.57951141
25MAP3K111.55683583
26TBK11.50170983
27IKBKB1.43938955
28TNK21.40670339
29CDK191.35615866
30PRKCQ1.30133135
31HCK1.23451773
32MAP3K141.20796173
33CAMKK21.13630825
34MAPKAPK31.09643595
35JAK21.04397636
36JAK11.01236040
37TLK10.98060699
38FGR0.94115743
39GRK70.92031142
40PDK10.85297592
41BMPR1B0.85289940
42ADRBK20.83878596
43FYN0.75170804
44SIK30.72538577
45ERN10.70287205
46BMPR20.69235272
47MAP3K130.69197278
48DAPK10.68753360
49MAP2K60.68713612
50TESK10.67942563
51CAMKK10.67455306
52MAPK110.67439399
53MST40.65903353
54PIM10.65551578
55VRK20.64720449
56STK100.63091331
57SIK20.60018128
58NUAK10.56065958
59CDK80.55068673
60VRK10.54188835
61TAOK20.52892595
62MATK0.52463815
63PASK0.51391296
64MAPK120.49799647
65PIK3CG0.49467021
66IGF1R0.47734571
67GRK10.46910865
68TGFBR20.46765601
69TIE10.46005583
70LRRK20.45455427
71FRK0.44806490
72MAP2K30.44215130
73MARK30.43827316
74MAPKAPK20.42062858
75PRPF4B0.41991986
76MAP4K20.41977368
77MAPK130.41005081
78DAPK20.38772428
79TGFBR10.38078839
80SCYL20.37474235
81CDK40.36743789
82MAP2K20.36130879
83NLK0.36095526
84PRKCH0.35630463
85RPS6KA50.34582716
86TAOK10.34490145
87CHUK0.34349356
88INSR0.34005337
89MAPK30.31057768
90ABL10.30313105
91CLK10.29591777
92MUSK0.29313137
93MAPK70.28357081
94OXSR10.27894851
95GRK50.27502063
96EGFR0.25695538
97PRKCD0.24877204
98STK110.22245244
99PDPK10.20626211
100MAP3K30.18527451

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.42329557
2Graft-versus-host disease_Homo sapiens_hsa053323.95140665
3Autoimmune thyroid disease_Homo sapiens_hsa053203.84444725
4Allograft rejection_Homo sapiens_hsa053303.80684477
5Antigen processing and presentation_Homo sapiens_hsa046123.65546545
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.99107884
7Type I diabetes mellitus_Homo sapiens_hsa049402.89228486
8Hematopoietic cell lineage_Homo sapiens_hsa046402.85928184
9Asthma_Homo sapiens_hsa053102.75266543
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.67347541
11T cell receptor signaling pathway_Homo sapiens_hsa046602.40684985
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39012192
13Leishmaniasis_Homo sapiens_hsa051402.33706927
14Staphylococcus aureus infection_Homo sapiens_hsa051502.18842701
15Viral myocarditis_Homo sapiens_hsa054162.08586610
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.04411642
17Rheumatoid arthritis_Homo sapiens_hsa053231.98901923
18Measles_Homo sapiens_hsa051621.95237316
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92625633
20Osteoclast differentiation_Homo sapiens_hsa043801.68891103
21Proteasome_Homo sapiens_hsa030501.66451044
22B cell receptor signaling pathway_Homo sapiens_hsa046621.57159819
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49068336
24Herpes simplex infection_Homo sapiens_hsa051681.45740005
25Malaria_Homo sapiens_hsa051441.44333981
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39260027
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36849045
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36479012
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35863907
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.33583165
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33387277
32Tuberculosis_Homo sapiens_hsa051521.24906198
33Influenza A_Homo sapiens_hsa051641.15919238
34Shigellosis_Homo sapiens_hsa051311.13137232
35Chemokine signaling pathway_Homo sapiens_hsa040621.11541019
36Legionellosis_Homo sapiens_hsa051341.02536204
37Systemic lupus erythematosus_Homo sapiens_hsa053220.98109640
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95546018
39Toxoplasmosis_Homo sapiens_hsa051450.88255916
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85490450
41Salmonella infection_Homo sapiens_hsa051320.84929031
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81469865
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79711386
44TNF signaling pathway_Homo sapiens_hsa046680.77711554
45Phagosome_Homo sapiens_hsa041450.77190540
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76583044
47African trypanosomiasis_Homo sapiens_hsa051430.71491266
48Platelet activation_Homo sapiens_hsa046110.69633690
49Epstein-Barr virus infection_Homo sapiens_hsa051690.67809206
50Pertussis_Homo sapiens_hsa051330.67586141
51HTLV-I infection_Homo sapiens_hsa051660.63700514
52Apoptosis_Homo sapiens_hsa042100.63698380
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58025290
54Regulation of autophagy_Homo sapiens_hsa041400.56110282
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.53665880
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52429471
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50837418
58Viral carcinogenesis_Homo sapiens_hsa052030.50575659
59Hepatitis B_Homo sapiens_hsa051610.48536060
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47226862
61Acute myeloid leukemia_Homo sapiens_hsa052210.47058117
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43841677
63Endocytosis_Homo sapiens_hsa041440.43196370
64Parkinsons disease_Homo sapiens_hsa050120.43129684
65Nitrogen metabolism_Homo sapiens_hsa009100.42655606
66Oxidative phosphorylation_Homo sapiens_hsa001900.40384071
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38387935
68Lysosome_Homo sapiens_hsa041420.35186069
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34379048
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32155658
71Linoleic acid metabolism_Homo sapiens_hsa005910.32041792
72Hepatitis C_Homo sapiens_hsa051600.29718323
73Phototransduction_Homo sapiens_hsa047440.29378728
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27995345
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25345518
76Non-small cell lung cancer_Homo sapiens_hsa052230.24468171
77Collecting duct acid secretion_Homo sapiens_hsa049660.24453631
78Olfactory transduction_Homo sapiens_hsa047400.20292446
79Arachidonic acid metabolism_Homo sapiens_hsa005900.18622047
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17785186
81VEGF signaling pathway_Homo sapiens_hsa043700.15476630
82Dorso-ventral axis formation_Homo sapiens_hsa043200.13601133
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13152736
84Peroxisome_Homo sapiens_hsa041460.12042724
85MAPK signaling pathway_Homo sapiens_hsa040100.11067164
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10633093
87Ovarian steroidogenesis_Homo sapiens_hsa049130.10344590
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10190112
89Other glycan degradation_Homo sapiens_hsa005110.07957109
90Morphine addiction_Homo sapiens_hsa050320.07644441
91Alzheimers disease_Homo sapiens_hsa050100.06347730
92Fanconi anemia pathway_Homo sapiens_hsa034600.06145706
93Alcoholism_Homo sapiens_hsa050340.06059284
94Ras signaling pathway_Homo sapiens_hsa040140.05844553
95Homologous recombination_Homo sapiens_hsa034400.04834164
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.03373196
97Prolactin signaling pathway_Homo sapiens_hsa049170.02121675
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02107613
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.00706437
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.00626783

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