ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.70478135
2	L-fucose catabolic process (GO:0042355)	4.87306135
3	fucose catabolic process (GO:0019317)	4.87306135
4	L-fucose metabolic process (GO:0042354)	4.87306135
5	response to pheromone (GO:0019236)	4.31932023
6	DNA deamination (GO:0045006)	4.30749123
7	platelet dense granule organization (GO:0060155)	3.92276248
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79704413
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.75127504
10	cellular ketone body metabolic process (GO:0046950)	3.71230186
11	indolalkylamine metabolic process (GO:0006586)	3.64343633
12	indole-containing compound catabolic process (GO:0042436)	3.62099304
13	indolalkylamine catabolic process (GO:0046218)	3.62099304
14	tryptophan catabolic process (GO:0006569)	3.62099304
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.59905580
16	negative regulation of telomere maintenance (GO:0032205)	3.54618406
17	respiratory chain complex IV assembly (GO:0008535)	3.46290615
18	preassembly of GPI anchor in ER membrane (GO:0016254)	3.45825776
19	piRNA metabolic process (GO:0034587)	3.45510461
20	ketone body metabolic process (GO:1902224)	3.37678350
21	kynurenine metabolic process (GO:0070189)	3.37190592
22	epithelial cilium movement (GO:0003351)	3.24048817
23	tryptophan metabolic process (GO:0006568)	3.22127221
24	protein polyglutamylation (GO:0018095)	3.19783570
25	protein-cofactor linkage (GO:0018065)	3.14137474
26	kidney morphogenesis (GO:0060993)	3.05939770
27	ubiquinone biosynthetic process (GO:0006744)	3.03134513
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.02210151
29	detection of light stimulus involved in visual perception (GO:0050908)	3.02210151
30	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.01910199
31	pseudouridine synthesis (GO:0001522)	3.01195616
32	regulation of glucokinase activity (GO:0033131)	2.99483241
33	regulation of hexokinase activity (GO:1903299)	2.99483241
34	regulation of cilium movement (GO:0003352)	2.94579102
35	axoneme assembly (GO:0035082)	2.93934797
36	rRNA catabolic process (GO:0016075)	2.92726738
37	cornea development in camera-type eye (GO:0061303)	2.92509185
38	cytochrome complex assembly (GO:0017004)	2.92318080
39	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.90997236
40	neuronal action potential (GO:0019228)	2.89804012
41	DNA methylation involved in gamete generation (GO:0043046)	2.89011635
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.87157420
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.87157420
44	NADH dehydrogenase complex assembly (GO:0010257)	2.87157420
45	ubiquinone metabolic process (GO:0006743)	2.85487144
46	indole-containing compound metabolic process (GO:0042430)	2.84451769
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.84181665
48	protein complex biogenesis (GO:0070271)	2.83613374
49	adaptation of signaling pathway (GO:0023058)	2.80498170
50	cilium morphogenesis (GO:0060271)	2.79625900
51	neural tube formation (GO:0001841)	2.78217603
52	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.78136384
53	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.76486323
54	mannosylation (GO:0097502)	2.75983850
55	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69476792
56	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.69075544
57	cullin deneddylation (GO:0010388)	2.68587660
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.67696062
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67310642
60	primary amino compound metabolic process (GO:1901160)	2.67142106
61	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.64655595
62	regulation of mitotic spindle checkpoint (GO:1903504)	2.64655595
63	gamma-aminobutyric acid transport (GO:0015812)	2.64483739
64	photoreceptor cell maintenance (GO:0045494)	2.64362886
65	positive regulation of prostaglandin secretion (GO:0032308)	2.64139796
66	cellular biogenic amine catabolic process (GO:0042402)	2.63992529
67	amine catabolic process (GO:0009310)	2.63992529
68	negative regulation of mast cell activation (GO:0033004)	2.62739636
69	inositol phosphate catabolic process (GO:0071545)	2.62614429
70	nonmotile primary cilium assembly (GO:0035058)	2.60773473
71	neuronal action potential propagation (GO:0019227)	2.60527630
72	inositol phosphate dephosphorylation (GO:0046855)	2.60422760
73	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.60422760
74	positive regulation of fatty acid transport (GO:2000193)	2.60107304
75	protein deneddylation (GO:0000338)	2.59811779
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.59654212
77	polyol catabolic process (GO:0046174)	2.58826811
78	maturation of 5.8S rRNA (GO:0000460)	2.57794258
79	rhodopsin mediated signaling pathway (GO:0016056)	2.56573995
80	replication fork processing (GO:0031297)	2.56506496
81	behavioral response to ethanol (GO:0048149)	2.55957179
82	S-adenosylmethionine metabolic process (GO:0046500)	2.53227537
83	regulation of action potential (GO:0098900)	2.53141160
84	cilium movement (GO:0003341)	2.52564006
85	GPI anchor metabolic process (GO:0006505)	2.52166696
86	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51845751
87	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51845751
88	dopamine transport (GO:0015872)	2.50027535
89	synaptic transmission, cholinergic (GO:0007271)	2.49988249
90	sulfation (GO:0051923)	2.49333951
91	amino acid salvage (GO:0043102)	2.48913531
92	L-methionine salvage (GO:0071267)	2.48913531
93	L-methionine biosynthetic process (GO:0071265)	2.48913531
94	cilium organization (GO:0044782)	2.48640432
95	magnesium ion transport (GO:0015693)	2.46836896
96	DNA double-strand break processing (GO:0000729)	2.46787674
97	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.46728603
98	protein localization to cilium (GO:0061512)	2.45585047
99	serotonin metabolic process (GO:0042428)	2.45196143
100	adenosine metabolic process (GO:0046085)	2.43823435

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.24081010
2	VDR_22108803_ChIP-Seq_LS180_Human	3.28613511
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.23423530
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70352333
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.68894300
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58095424
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41428325
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.39340738
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25988488
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24000676
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.20864016
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15254930
13	* EWS_26573619_Chip-Seq_HEK293_Human	2.09507479
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06274910
15	FUS_26573619_Chip-Seq_HEK293_Human	2.05726280
16	P300_19829295_ChIP-Seq_ESCs_Human	2.03800171
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.99965556
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.96875438
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.84457593
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84323175
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83255950
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81860041
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80717140
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.76994164
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76775022
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.72730156
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70288411
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.68638862
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61676291
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.59857995
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59556457
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58146158
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57572748
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.57175455
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57084608
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54145127
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.54145127
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51081883
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46748647
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46343576
41	STAT3_23295773_ChIP-Seq_U87_Human	1.45935324
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40814505
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39486487
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39486487
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37888173
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36901944
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36351496
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36219979
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34835023
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34043773
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34043773
52	AR_25329375_ChIP-Seq_VCAP_Human	1.33824842
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33203050
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31199524
55	AR_20517297_ChIP-Seq_VCAP_Human	1.31195129
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30071799
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.27360989
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26270678
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26091628
60	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25066960
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24395149
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24395149
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23551711
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21684756
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.21411938
66	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21088872
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21057993
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20770899
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20356592
70	NCOR_22424771_ChIP-Seq_293T_Human	1.19024064
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18749430
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17948942
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17776084
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17211309
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16946671
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15971311
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15624757
78	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15074246
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14133284
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12116594
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10118923
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09155439
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08517079
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07870404
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07366896
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07046767
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.05123650
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05049385
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04855481
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04780389
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03498991
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03443914
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03253638
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02852199
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02552291
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02024975
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99111873
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98802985
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95894676
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.95009138

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.69776569
2	MP0003195_calcinosis	3.07342512
3	MP0002102_abnormal_ear_morphology	2.75977506
4	MP0003787_abnormal_imprinting	2.61782476
5	MP0001968_abnormal_touch/_nociception	2.43539757
6	MP0005551_abnormal_eye_electrophysiolog	2.40243168
7	MP0002876_abnormal_thyroid_physiology	2.28302827
8	MP0006072_abnormal_retinal_apoptosis	2.20376151
9	MP0002837_dystrophic_cardiac_calcinosis	2.10567678
10	MP0005645_abnormal_hypothalamus_physiol	2.06357068
11	MP0002736_abnormal_nociception_after	2.00846362
12	MP0002138_abnormal_hepatobiliary_system	2.00616993
13	MP0008872_abnormal_physiological_respon	1.98776737
14	MP0008875_abnormal_xenobiotic_pharmacok	1.93527723
15	MP0001986_abnormal_taste_sensitivity	1.93010590
16	MP0003646_muscle_fatigue	1.87792473
17	MP0005253_abnormal_eye_physiology	1.86590437
18	MP0004147_increased_porphyrin_level	1.84141603
19	MP0000427_abnormal_hair_cycle	1.83575151
20	MP0004043_abnormal_pH_regulation	1.83414719
21	MP0005646_abnormal_pituitary_gland	1.78938419
22	MP0004885_abnormal_endolymph	1.78701701
23	MP0001501_abnormal_sleep_pattern	1.78307795
24	MP0009745_abnormal_behavioral_response	1.78117205
25	MP0003011_delayed_dark_adaptation	1.75184297
26	MP0003880_abnormal_central_pattern	1.69590740
27	MP0009046_muscle_twitch	1.68137787
28	MP0006292_abnormal_olfactory_placode	1.65369836
29	MP0005084_abnormal_gallbladder_morpholo	1.63377455
30	MP0002272_abnormal_nervous_system	1.62512006
31	MP0000569_abnormal_digit_pigmentation	1.62503702
32	MP0002653_abnormal_ependyma_morphology	1.61154520
33	MP0010386_abnormal_urinary_bladder	1.56450749
34	MP0000372_irregular_coat_pigmentation	1.56403758
35	MP0004133_heterotaxia	1.55827112
36	MP0004142_abnormal_muscle_tone	1.55401098
37	MP0001984_abnormal_olfaction	1.47495250
38	MP0002638_abnormal_pupillary_reflex	1.42246029
39	MP0001486_abnormal_startle_reflex	1.41615412
40	MP0001485_abnormal_pinna_reflex	1.38118191
41	MP0006276_abnormal_autonomic_nervous	1.36065283
42	MP0003718_maternal_effect	1.35983611
43	MP0000631_abnormal_neuroendocrine_gland	1.35808240
44	MP0002234_abnormal_pharynx_morphology	1.35107336
45	MP0003136_yellow_coat_color	1.34533044
46	MP0002938_white_spotting	1.33307950
47	MP0003283_abnormal_digestive_organ	1.27112056
48	MP0005085_abnormal_gallbladder_physiolo	1.25918343
49	MP0001529_abnormal_vocalization	1.24202585
50	MP0005379_endocrine/exocrine_gland_phen	1.22915124
51	MP0002572_abnormal_emotion/affect_behav	1.19126022
52	MP0005174_abnormal_tail_pigmentation	1.18389340
53	MP0008058_abnormal_DNA_repair	1.18316762
54	MP0002557_abnormal_social/conspecific_i	1.17404411
55	MP0005389_reproductive_system_phenotype	1.13786090
56	MP0001764_abnormal_homeostasis	1.13656508
57	MP0002064_seizures	1.13578616
58	MP0002733_abnormal_thermal_nociception	1.12729642
59	MP0001970_abnormal_pain_threshold	1.12394424
60	MP0004145_abnormal_muscle_electrophysio	1.11123966
61	MP0002928_abnormal_bile_duct	1.09506453
62	MP0005365_abnormal_bile_salt	1.05526835
63	MP0005410_abnormal_fertilization	1.05329025
64	MP0005377_hearing/vestibular/ear_phenot	1.04797736
65	MP0003878_abnormal_ear_physiology	1.04797736
66	MP0004742_abnormal_vestibular_system	1.04734916
67	MP0002160_abnormal_reproductive_system	1.04072317
68	MP0002163_abnormal_gland_morphology	1.02496667
69	MP0005167_abnormal_blood-brain_barrier	1.01440755
70	MP0005332_abnormal_amino_acid	0.99277736
71	MP0002277_abnormal_respiratory_mucosa	0.96043827
72	MP0008789_abnormal_olfactory_epithelium	0.95710873
73	MP0000647_abnormal_sebaceous_gland	0.95178193
74	MP0003121_genomic_imprinting	0.95005029
75	MP0002751_abnormal_autonomic_nervous	0.95000789
76	MP0000383_abnormal_hair_follicle	0.93983878
77	MP0001919_abnormal_reproductive_system	0.93307197
78	MP0002067_abnormal_sensory_capabilities	0.93027157
79	MP0000230_abnormal_systemic_arterial	0.92867446
80	MP0008995_early_reproductive_senescence	0.92770375
81	MP0005195_abnormal_posterior_eye	0.90639453
82	MP0003252_abnormal_bile_duct	0.90003969
83	MP0002254_reproductive_system_inflammat	0.89538868
84	MP0004215_abnormal_myocardial_fiber	0.88648370
85	MP0004924_abnormal_behavior	0.88165708
86	MP0005386_behavior/neurological_phenoty	0.88165708
87	MP0008775_abnormal_heart_ventricle	0.87918067
88	MP0001929_abnormal_gametogenesis	0.87015560
89	MP0010329_abnormal_lipoprotein_level	0.85136838
90	MP0005671_abnormal_response_to	0.84973427
91	MP0003137_abnormal_impulse_conducting	0.84353268
92	MP0002735_abnormal_chemical_nociception	0.84259512
93	MP0003698_abnormal_male_reproductive	0.83368848
94	MP0002095_abnormal_skin_pigmentation	0.83204209
95	MP0002693_abnormal_pancreas_physiology	0.81937304
96	MP0002734_abnormal_mechanical_nocicepti	0.81176228
97	MP0001905_abnormal_dopamine_level	0.78352455
98	MP0000538_abnormal_urinary_bladder	0.77623521
99	MP0003635_abnormal_synaptic_transmissio	0.75899864
100	MP0002063_abnormal_learning/memory/cond	0.75734952

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.48743439
2	Molar tooth sign on MRI (HP:0002419)	4.14507533
3	Abnormality of midbrain morphology (HP:0002418)	4.14507533
4	Pancreatic fibrosis (HP:0100732)	4.10718145
5	True hermaphroditism (HP:0010459)	3.77674143
6	Nephronophthisis (HP:0000090)	3.76943667
7	Congenital stationary night blindness (HP:0007642)	3.56313982
8	Abnormality of the renal cortex (HP:0011035)	3.39197868
9	Type II lissencephaly (HP:0007260)	3.35082913
10	Abnormality of the renal medulla (HP:0100957)	3.29246783
11	Medial flaring of the eyebrow (HP:0010747)	3.13933725
12	Hyperventilation (HP:0002883)	3.05337732
13	Tubular atrophy (HP:0000092)	2.98940713
14	Abnormal drinking behavior (HP:0030082)	2.94978681
15	Polydipsia (HP:0001959)	2.94978681
16	Attenuation of retinal blood vessels (HP:0007843)	2.93265768
17	Chronic hepatic failure (HP:0100626)	2.86797377
18	Abnormality of alanine metabolism (HP:0010916)	2.71575600
19	Hyperalaninemia (HP:0003348)	2.71575600
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71575600
21	Abolished electroretinogram (ERG) (HP:0000550)	2.71040985
22	Cystic liver disease (HP:0006706)	2.66918177
23	Large for gestational age (HP:0001520)	2.65619170
24	Pendular nystagmus (HP:0012043)	2.58625724
25	Progressive inability to walk (HP:0002505)	2.53381690
26	Inability to walk (HP:0002540)	2.52239956
27	Renal cortical cysts (HP:0000803)	2.49489656
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.48920017
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.40302895
30	Absent/shortened dynein arms (HP:0200106)	2.40302895
31	Lissencephaly (HP:0001339)	2.39534360
32	Methylmalonic acidemia (HP:0002912)	2.38200092
33	Polyuria (HP:0000103)	2.36593611
34	Gaze-evoked nystagmus (HP:0000640)	2.36010558
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31262052
36	Gait imbalance (HP:0002141)	2.30257736
37	Acute necrotizing encephalopathy (HP:0006965)	2.26960494
38	Keratoconus (HP:0000563)	2.26634082
39	Increased corneal curvature (HP:0100692)	2.26634082
40	Congenital hepatic fibrosis (HP:0002612)	2.23064458
41	Congenital primary aphakia (HP:0007707)	2.22838477
42	Bile duct proliferation (HP:0001408)	2.21391275
43	Abnormal biliary tract physiology (HP:0012439)	2.21391275
44	Ketoacidosis (HP:0001993)	2.19484321
45	Sclerocornea (HP:0000647)	2.18393939
46	Increased CSF lactate (HP:0002490)	2.16062945
47	Acute encephalopathy (HP:0006846)	2.15842624
48	Methylmalonic aciduria (HP:0012120)	2.14519209
49	Cerebellar dysplasia (HP:0007033)	2.13201356
50	Congenital, generalized hypertrichosis (HP:0004540)	2.12747547
51	Hyperglycinuria (HP:0003108)	2.12147436
52	Hypothermia (HP:0002045)	2.11864071
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10476902
54	Nephrogenic diabetes insipidus (HP:0009806)	2.10394511
55	Intestinal atresia (HP:0011100)	2.10010541
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08425170
57	Progressive macrocephaly (HP:0004481)	2.07835298
58	Mitochondrial inheritance (HP:0001427)	2.06217152
59	Pachygyria (HP:0001302)	2.05926608
60	Stomach cancer (HP:0012126)	2.05889721
61	Retinal dysplasia (HP:0007973)	2.05683427
62	Colon cancer (HP:0003003)	2.01265867
63	Furrowed tongue (HP:0000221)	2.00671795
64	Hemiparesis (HP:0001269)	1.99556108
65	Decreased circulating renin level (HP:0003351)	1.98868565
66	Decreased central vision (HP:0007663)	1.98557152
67	Hypomagnesemia (HP:0002917)	1.98505828
68	Optic disc pallor (HP:0000543)	1.97143274
69	Severe muscular hypotonia (HP:0006829)	1.96239950
70	Ketosis (HP:0001946)	1.95653738
71	Fair hair (HP:0002286)	1.93333804
72	Chorioretinal atrophy (HP:0000533)	1.91961983
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90738278
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.90261240
75	Anencephaly (HP:0002323)	1.89912578
76	Abnormal urine output (HP:0012590)	1.89631315
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89533871
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.89327626
79	Broad-based gait (HP:0002136)	1.88558668
80	Febrile seizures (HP:0002373)	1.85366448
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83146082
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.83146082
83	3-Methylglutaconic aciduria (HP:0003535)	1.82099425
84	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81679470
85	Concave nail (HP:0001598)	1.80051407
86	Male pseudohermaphroditism (HP:0000037)	1.78796582
87	Progressive microcephaly (HP:0000253)	1.78673188
88	Abnormality of the pons (HP:0007361)	1.77948995
89	Genital tract atresia (HP:0001827)	1.77715842
90	Postaxial foot polydactyly (HP:0001830)	1.76292300
91	Optic nerve hypoplasia (HP:0000609)	1.76028379
92	Abnormality of glycine metabolism (HP:0010895)	1.75614657
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.75614657
94	Increased serum lactate (HP:0002151)	1.75537840
95	Hypoplasia of the pons (HP:0012110)	1.75297558
96	Lipid accumulation in hepatocytes (HP:0006561)	1.74783623
97	Agitation (HP:0000713)	1.74229991
98	Patellar aplasia (HP:0006443)	1.74151896
99	Thyroiditis (HP:0100646)	1.74127239
100	Tachypnea (HP:0002789)	1.71267548

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.34711679
2	ADRBK2	3.19117545
3	MAP4K2	3.13691515
4	BMPR1B	2.78295578
5	TAOK3	2.65975699
6	ZAK	2.48351116
7	WNK4	2.41266582
8	WNK3	2.38825520
9	GRK1	2.34360665
10	NUAK1	2.22504541
11	PINK1	2.21042362
12	INSRR	2.20995249
13	TLK1	2.19061653
14	ACVR1B	2.12399367
15	OXSR1	1.82587198
16	DAPK2	1.80242853
17	TNIK	1.74381848
18	STK39	1.72886455
19	MKNK2	1.65841908
20	MAP3K4	1.60786753
21	MAPK13	1.58613035
22	TXK	1.57415123
23	TRIM28	1.47770321
24	CASK	1.34481508
25	MST4	1.31657884
26	ADRBK1	1.19327071
27	PAK3	1.18928492
28	PLK2	1.15448947
29	PHKG2	1.13760628
30	PHKG1	1.13760628
31	DYRK2	1.09117456
32	EIF2AK3	1.07349084
33	PRKCE	1.02728004
34	PRKCG	0.99846851
35	BCKDK	0.96953916
36	CAMKK2	0.96708445
37	BCR	0.96022373
38	CSNK1G2	0.92795002
39	CSNK1G1	0.89799524
40	MKNK1	0.89286572
41	CSNK1G3	0.88564215
42	ERBB3	0.86893273
43	TGFBR1	0.85351632
44	TAF1	0.84623342
45	TIE1	0.83219376
46	STK38L	0.79752979
47	VRK1	0.79284707
48	VRK2	0.79273584
49	MARK1	0.77727860
50	MAPKAPK3	0.76685312
51	PTK2B	0.76242417
52	PIK3CA	0.75941770
53	CSNK1A1L	0.75050454
54	IKBKB	0.71786169
55	PLK4	0.71134746
56	PLK3	0.70914367
57	MAP2K7	0.66313360
58	TEC	0.64933705
59	NME1	0.63382261
60	PRKCI	0.62438622
61	AKT3	0.61667511
62	KIT	0.60717159
63	GRK7	0.60364778
64	BRSK2	0.59780411
65	MAPKAPK5	0.59764527
66	PNCK	0.58703817
67	TSSK6	0.53311830
68	FGFR2	0.53147038
69	STK3	0.52990389
70	NTRK3	0.52534885
71	EIF2AK2	0.51453970
72	CAMK2A	0.51057220
73	PRKCQ	0.50085545
74	EPHA4	0.49306213
75	MAP2K6	0.48826016
76	IRAK1	0.48520487
77	RPS6KA5	0.48066680
78	STK16	0.47876425
79	PRKACA	0.42750287
80	EPHA3	0.42425758
81	CSNK1A1	0.42359208
82	GRK5	0.41176353
83	ITK	0.39551523
84	CHUK	0.39166751
85	PLK1	0.38877594
86	FLT3	0.38284048
87	CSNK1D	0.37619257
88	STK11	0.36299399
89	CAMK1	0.34316324
90	PKN1	0.33681785
91	ATR	0.32303370
92	DAPK1	0.31852087
93	IRAK4	0.31831550
94	PRKCA	0.31705730
95	FER	0.31408216
96	MUSK	0.31054943
97	CHEK2	0.30688470
98	NLK	0.29869616
99	PRKG1	0.29712953
100	OBSCN	0.29349028

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.85608191
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.63139113
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.62808538
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50678746
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.43045667
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42776318
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39760879
8	Butanoate metabolism_Homo sapiens_hsa00650	2.27992705
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.19559949
10	Protein export_Homo sapiens_hsa03060	2.18607931
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.14775329
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03036475
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02285348
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00316303
15	RNA polymerase_Homo sapiens_hsa03020	1.95672941
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.84953204
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83843620
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.83101729
19	Propanoate metabolism_Homo sapiens_hsa00640	1.76877027
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.76562613
21	Nicotine addiction_Homo sapiens_hsa05033	1.74218317
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.73781990
23	Basal transcription factors_Homo sapiens_hsa03022	1.62483951
24	Parkinsons disease_Homo sapiens_hsa05012	1.56717868
25	Homologous recombination_Homo sapiens_hsa03440	1.55860015
26	Caffeine metabolism_Homo sapiens_hsa00232	1.52679344
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51831254
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48576476
29	Peroxisome_Homo sapiens_hsa04146	1.46204960
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40665416
31	RNA degradation_Homo sapiens_hsa03018	1.40619734
32	Asthma_Homo sapiens_hsa05310	1.28456374
33	One carbon pool by folate_Homo sapiens_hsa00670	1.20421415
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19125376
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.17404260
36	Taste transduction_Homo sapiens_hsa04742	1.16426489
37	Regulation of autophagy_Homo sapiens_hsa04140	1.16351585
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16158768
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13627097
40	Olfactory transduction_Homo sapiens_hsa04740	1.10984918
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10745857
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04443418
43	Morphine addiction_Homo sapiens_hsa05032	1.02317799
44	Huntingtons disease_Homo sapiens_hsa05016	1.02121386
45	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01370800
46	Sulfur metabolism_Homo sapiens_hsa00920	0.97982000
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97380091
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.97192335
49	ABC transporters_Homo sapiens_hsa02010	0.95930229
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94444031
51	Alzheimers disease_Homo sapiens_hsa05010	0.94043149
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91315692
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89751451
54	Retinol metabolism_Homo sapiens_hsa00830	0.89741446
55	Insulin secretion_Homo sapiens_hsa04911	0.83897612
56	Proteasome_Homo sapiens_hsa03050	0.82229605
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81261887
58	Serotonergic synapse_Homo sapiens_hsa04726	0.80947512
59	Circadian entrainment_Homo sapiens_hsa04713	0.79489739
60	Purine metabolism_Homo sapiens_hsa00230	0.79129453
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77841118
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77359568
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76119771
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75386605
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74316582
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.72969066
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71340731
68	GABAergic synapse_Homo sapiens_hsa04727	0.70837586
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70595989
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.68860782
71	Metabolic pathways_Homo sapiens_hsa01100	0.68077494
72	Sulfur relay system_Homo sapiens_hsa04122	0.63041432
73	Allograft rejection_Homo sapiens_hsa05330	0.62530343
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60882149
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60654270
76	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.59730481
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59582807
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58837500
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57702966
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57639066
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.56755665
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.56021630
83	Histidine metabolism_Homo sapiens_hsa00340	0.55904456
84	Circadian rhythm_Homo sapiens_hsa04710	0.54219804
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54156512
86	Salivary secretion_Homo sapiens_hsa04970	0.53983457
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.52860428
88	Fatty acid degradation_Homo sapiens_hsa00071	0.48785187
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48688657
90	Fatty acid elongation_Homo sapiens_hsa00062	0.48171290
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.45779265
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.44824244
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44612443
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42844859
95	Mineral absorption_Homo sapiens_hsa04978	0.42025220
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40064239
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39474676
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39342875
99	Long-term depression_Homo sapiens_hsa04730	0.37262163
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35370903

CEACAM22P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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