CEACAM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.95789309
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.95789309
3modulation by symbiont of host immune response (GO:0052553)5.95789309
4positive regulation by symbiont of host defense response (GO:0052509)5.95789309
5modulation by symbiont of host defense response (GO:0052031)5.95789309
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.95789309
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88205357
8neutrophil activation involved in immune response (GO:0002283)5.73605704
9antigen processing and presentation of endogenous antigen (GO:0019883)5.62516649
10negative regulation of cell killing (GO:0031342)5.47846683
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47846683
12detection of other organism (GO:0098543)5.44575827
13detection of bacterium (GO:0016045)5.24771644
14positive regulation of gamma-delta T cell activation (GO:0046645)5.21808422
15immunoglobulin mediated immune response (GO:0016064)5.15071600
16response to peptidoglycan (GO:0032494)5.10791443
17regulation of B cell receptor signaling pathway (GO:0050855)5.00908081
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86768494
19macrophage activation involved in immune response (GO:0002281)4.83283484
20detection of external biotic stimulus (GO:0098581)4.58882384
21cellular extravasation (GO:0045123)4.53994500
22regulation of mast cell degranulation (GO:0043304)4.48138197
23neutrophil activation (GO:0042119)4.44767754
24production of molecular mediator involved in inflammatory response (GO:0002532)4.42517048
25response to host immune response (GO:0052572)4.42465915
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.42465915
27microglial cell activation (GO:0001774)4.41816994
28leukocyte aggregation (GO:0070486)4.33176882
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31472380
30leukocyte migration involved in inflammatory response (GO:0002523)4.29972110
31negative regulation of interleukin-12 production (GO:0032695)4.28387373
32regulation of interferon-beta biosynthetic process (GO:0045357)4.26886544
33detection of molecule of bacterial origin (GO:0032490)4.23776432
34respiratory burst (GO:0045730)4.19493033
35positive thymic T cell selection (GO:0045059)4.17887117
36regulation of mast cell activation involved in immune response (GO:0033006)4.13031810
37neutrophil mediated immunity (GO:0002446)4.12611888
38B cell mediated immunity (GO:0019724)4.10877755
39detection of biotic stimulus (GO:0009595)4.10528320
40regulation of myeloid leukocyte mediated immunity (GO:0002886)4.07329595
41regulation of mast cell activation (GO:0033003)4.05070772
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00843121
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.97184706
44response to host (GO:0075136)3.97184706
45response to host defenses (GO:0052200)3.97184706
46granulocyte activation (GO:0036230)3.96152803
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.95073901
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.90148510
49myeloid cell activation involved in immune response (GO:0002275)3.85883935
50regulation of leukocyte degranulation (GO:0043300)3.83952811
51negative regulation of leukocyte mediated immunity (GO:0002704)3.81776714
52macrophage activation (GO:0042116)3.81552930
53response to interleukin-15 (GO:0070672)3.74056432
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70977279
55negative regulation of phagocytosis (GO:0050765)3.68561617
56regulation of gamma-delta T cell activation (GO:0046643)3.65854017
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.65646730
58positive regulation of mast cell activation (GO:0033005)3.56779111
59positive regulation of B cell differentiation (GO:0045579)3.56539375
60positive regulation of antigen processing and presentation (GO:0002579)3.49518739
61antigen processing and presentation via MHC class Ib (GO:0002475)3.47201691
62myeloid leukocyte mediated immunity (GO:0002444)3.43221387
63cell wall macromolecule metabolic process (GO:0044036)3.43133829
64regulation of B cell differentiation (GO:0045577)3.40072604
65positive regulation of macrophage cytokine production (GO:0060907)3.40008875
66leukocyte degranulation (GO:0043299)3.37759651
67cellular response to interleukin-15 (GO:0071350)3.37149058
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37017924
69regulation of regulated secretory pathway (GO:1903305)3.36894069
70regulation of antigen processing and presentation (GO:0002577)3.35733131
71negative regulation of interleukin-6 production (GO:0032715)3.32823382
72interferon-gamma-mediated signaling pathway (GO:0060333)3.31178322
73cellular response to type I interferon (GO:0071357)3.30336684
74type I interferon signaling pathway (GO:0060337)3.30336684
75defense response to protozoan (GO:0042832)3.30109129
76response to type I interferon (GO:0034340)3.28905961
77regulation of macrophage cytokine production (GO:0010935)3.28577738
78positive T cell selection (GO:0043368)3.25352300
79regulation of gamma-delta T cell differentiation (GO:0045586)3.23357788
80B cell receptor signaling pathway (GO:0050853)3.23241926
81positive regulation of mast cell activation involved in immune response (GO:0033008)3.21543649
82positive regulation of mast cell degranulation (GO:0043306)3.21543649
83response to muramyl dipeptide (GO:0032495)3.19334546
84negative regulation of T cell mediated immunity (GO:0002710)3.16694008
85negative thymic T cell selection (GO:0045060)3.14706440
86positive regulation of interferon-alpha production (GO:0032727)3.13960616
87germinal center formation (GO:0002467)3.12904648
88regulation of interferon-alpha production (GO:0032647)3.00169791
89negative regulation of T-helper cell differentiation (GO:0045623)2.98612252
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98612252
91regulation of B cell apoptotic process (GO:0002902)2.97718569
92negative regulation of innate immune response (GO:0045824)2.97517780
93negative T cell selection (GO:0043383)2.97292647
94negative regulation of erythrocyte differentiation (GO:0045647)2.93729558
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92729623
96dendritic cell migration (GO:0036336)2.91638495
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90753294
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90007745
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87775236
100response to protozoan (GO:0001562)2.87661779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.25085507
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.11740704
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.41065858
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.83144862
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43162248
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07967489
7SCL_19346495_ChIP-Seq_HPC-7_Human3.05776813
8SPI1_23547873_ChIP-Seq_NB4_Human3.04725061
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.99947195
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88221575
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88022334
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84300036
13VDR_21846776_ChIP-Seq_THP-1_Human2.84247360
14VDR_24763502_ChIP-Seq_THP-1_Human2.77084555
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73091265
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62228937
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60151442
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51224147
19SPI1_23127762_ChIP-Seq_K562_Human2.50008145
20RUNX_20019798_ChIP-Seq_JUKART_Human2.42494765
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.34442877
22MYB_26560356_Chip-Seq_TH2_Human2.33228393
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23238981
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21787295
25MAF_26560356_Chip-Seq_TH1_Human2.19937498
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15280907
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.08499972
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06627541
29UTX_26944678_Chip-Seq_JUKART_Human2.05813232
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05238777
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99148079
32MYB_26560356_Chip-Seq_TH1_Human1.93332217
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89467405
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88021877
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87744799
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86527285
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82318746
38MYC_22102868_ChIP-Seq_BL_Human1.76595596
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74978568
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73467758
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72909171
42VDR_24787735_ChIP-Seq_THP-1_Human1.69480852
43GATA3_27048872_Chip-Seq_THYMUS_Human1.69107228
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65869102
45TCF7_22412390_ChIP-Seq_EML_Mouse1.63540792
46MAF_26560356_Chip-Seq_TH2_Human1.63020250
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58654223
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57944523
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56900144
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55019678
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.53780923
52GATA3_26560356_Chip-Seq_TH2_Human1.53332999
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52108347
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51658556
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38310739
56BCL6_27268052_Chip-Seq_Bcells_Human1.36634926
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35400531
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34561440
59KDM2B_26808549_Chip-Seq_DND41_Human1.32608175
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31156364
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25952521
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25751417
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23549971
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23408193
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21634386
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21600595
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20440540
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20105095
69GATA1_19941826_ChIP-Seq_K562_Human1.19973603
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19654823
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18928298
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18082810
73BCOR_27268052_Chip-Seq_Bcells_Human1.15919041
74PU_27001747_Chip-Seq_BMDM_Mouse1.14086830
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12747963
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12573212
77SPI1_20517297_ChIP-Seq_HL60_Human1.12030883
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11591675
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10066348
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08441006
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05489234
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.05314330
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04334095
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03817372
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03457069
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.02075036
87GATA1_22025678_ChIP-Seq_K562_Human1.01034289
88LXR_22292898_ChIP-Seq_THP-1_Human1.00789719
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99779167
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99521817
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.98648466
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.98575232
93CIITA_25753668_ChIP-Seq_RAJI_Human0.97888847
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96486330
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90251695
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88212449
97GATA2_19941826_ChIP-Seq_K562_Human0.88209999
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87708234
99P300_27268052_Chip-Seq_Bcells_Human0.85572488
100STAT1_20625510_ChIP-Seq_HELA_Human0.83959564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.04056776
2MP0003436_decreased_susceptibility_to4.26085841
3MP0001835_abnormal_antigen_presentation4.06797206
4MP0003303_peritoneal_inflammation3.73293117
5MP0002419_abnormal_innate_immunity3.32973177
6MP0009785_altered_susceptibility_to3.00068133
7MP0005025_abnormal_response_to2.97440711
8MP0001800_abnormal_humoral_immune2.95507284
9MP0005000_abnormal_immune_tolerance2.84980218
10MP0005671_abnormal_response_to2.76175129
11MP0003191_abnormal_cellular_cholesterol2.66306404
12MP0002723_abnormal_immune_serum2.65538910
13MP0002148_abnormal_hypersensitivity_rea2.59167096
14MP0001790_abnormal_immune_system2.57935617
15MP0005387_immune_system_phenotype2.57935617
16MP0002420_abnormal_adaptive_immunity2.57866107
17MP0002452_abnormal_antigen_presenting2.57288236
18MP0009278_abnormal_bone_marrow2.55523625
19MP0000685_abnormal_immune_system2.55368619
20MP0001819_abnormal_immune_cell2.55154920
21MP0005464_abnormal_platelet_physiology2.29881889
22MP0006082_CNS_inflammation2.24743871
23MP0001533_abnormal_skeleton_physiology2.13896823
24MP0003183_abnormal_peptide_metabolism2.13604992
25MP0003172_abnormal_lysosome_physiology2.12026570
26MP0005397_hematopoietic_system_phenotyp2.06595277
27MP0001545_abnormal_hematopoietic_system2.06595277
28MP0002405_respiratory_system_inflammati2.04698639
29MP0000716_abnormal_immune_system1.94437240
30MP0002398_abnormal_bone_marrow1.93096571
31MP0003763_abnormal_thymus_physiology1.92579445
32MP0000465_gastrointestinal_hemorrhage1.88281782
33MP0001845_abnormal_inflammatory_respons1.85591673
34MP0003300_gastrointestinal_ulcer1.85302823
35MP0010155_abnormal_intestine_physiology1.84846846
36MP0002132_abnormal_respiratory_system1.83735720
37MP0003806_abnormal_nucleotide_metabolis1.69354030
38MP0002396_abnormal_hematopoietic_system1.66636977
39MP0008260_abnormal_autophagy1.64789173
40MP0009764_decreased_sensitivity_to1.63654273
41MP0003866_abnormal_defecation1.60342871
42MP0000689_abnormal_spleen_morphology1.59946918
43MP0008469_abnormal_protein_level1.59444708
44MP0002722_abnormal_immune_system1.58346574
45MP0002429_abnormal_blood_cell1.54249100
46MP0003828_pulmonary_edema1.51604389
47MP0002277_abnormal_respiratory_mucosa1.48949064
48MP0003075_altered_response_to1.47776850
49MP0004947_skin_inflammation1.40116878
50MP0005058_abnormal_lysosome_morphology1.36927786
51MP0009333_abnormal_splenocyte_physiolog1.36567305
52MP0000703_abnormal_thymus_morphology1.28409012
53MP0001851_eye_inflammation1.28158878
54MP0000858_altered_metastatic_potential1.27382150
55MP0004883_abnormal_blood_vessel1.22535025
56MP0004381_abnormal_hair_follicle1.19978141
57MP0002166_altered_tumor_susceptibility1.17313235
58MP0005451_abnormal_body_composition1.03155636
59MP0005075_abnormal_melanosome_morpholog1.01570393
60MP0005164_abnormal_response_to1.01469615
61MP0004808_abnormal_hematopoietic_stem0.99219742
62MP0009763_increased_sensitivity_to0.99104673
63MP0003690_abnormal_glial_cell0.96531738
64MP0002998_abnormal_bone_remodeling0.95390944
65MP0001663_abnormal_digestive_system0.91441971
66MP0005310_abnormal_salivary_gland0.91271233
67MP0005166_decreased_susceptibility_to0.89814441
68MP0005390_skeleton_phenotype0.89663399
69MP0000343_altered_response_to0.85191738
70MP0008004_abnormal_stomach_pH0.85132618
71MP0002138_abnormal_hepatobiliary_system0.84669896
72MP0009765_abnormal_xenobiotic_induced0.82192001
73MP0002928_abnormal_bile_duct0.79913929
74MP0001986_abnormal_taste_sensitivity0.78743911
75MP0004510_myositis0.74173678
76MP0002006_tumorigenesis0.73613017
77MP0005084_abnormal_gallbladder_morpholo0.71344698
78MP0000015_abnormal_ear_pigmentation0.71144796
79MP0003045_fibrosis0.70265296
80MP0005319_abnormal_enzyme/_coenzyme0.70032527
81MP0001853_heart_inflammation0.68539499
82MP0003011_delayed_dark_adaptation0.67356703
83MP0001873_stomach_inflammation0.65743757
84MP0003448_altered_tumor_morphology0.64777048
85MP0004130_abnormal_muscle_cell0.61779251
86MP0002019_abnormal_tumor_incidence0.60384052
87MP0000490_abnormal_crypts_of0.58190433
88MP0008873_increased_physiological_sensi0.57329895
89MP0003252_abnormal_bile_duct0.57196349
90MP0003795_abnormal_bone_structure0.56192566
91MP0008874_decreased_physiological_sensi0.55283694
92MP0000604_amyloidosis0.55220889
93MP0000249_abnormal_blood_vessel0.54034249
94MP0003656_abnormal_erythrocyte_physiolo0.53956630
95MP0005376_homeostasis/metabolism_phenot0.52876054
96MP0000609_abnormal_liver_physiology0.52836498
97MP0005083_abnormal_biliary_tract0.52486797
98MP0003878_abnormal_ear_physiology0.50853484
99MP0005377_hearing/vestibular/ear_phenot0.50853484
100MP0002693_abnormal_pancreas_physiology0.50022317

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.09030243
2Myositis (HP:0100614)6.07759522
3Recurrent abscess formation (HP:0002722)5.80819705
4Recurrent bacterial skin infections (HP:0005406)5.63001940
5Elevated erythrocyte sedimentation rate (HP:0003565)5.54103568
6Orchitis (HP:0100796)5.50620692
7Stomatitis (HP:0010280)5.15279477
8Retrobulbar optic neuritis (HP:0100654)5.12922861
9Optic neuritis (HP:0100653)5.12922861
10Gastrointestinal infarctions (HP:0005244)5.11615494
11Abnormality of macrophages (HP:0004311)4.96420222
12Recurrent gram-negative bacterial infections (HP:0005420)4.71270236
13Obstructive lung disease (HP:0006536)4.62569819
14Chronic obstructive pulmonary disease (HP:0006510)4.62569819
15Mediastinal lymphadenopathy (HP:0100721)4.54930989
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.49667189
17Recurrent fungal infections (HP:0002841)4.33044099
18Meningitis (HP:0001287)4.31746169
19Recurrent cutaneous fungal infections (HP:0011370)4.17786384
20Chronic mucocutaneous candidiasis (HP:0002728)4.17786384
21Hypochromic microcytic anemia (HP:0004840)4.05122384
22Recurrent skin infections (HP:0001581)4.02727052
23Encephalitis (HP:0002383)3.88334426
24Keratoconjunctivitis sicca (HP:0001097)3.74027487
25Chest pain (HP:0100749)3.64002136
26Hypochromic anemia (HP:0001931)3.60039585
27Urticaria (HP:0001025)3.60030602
28Vasculitis (HP:0002633)3.56621797
29Prolonged bleeding time (HP:0003010)3.49521773
30Keratoconjunctivitis (HP:0001096)3.47944207
31Episodic fever (HP:0001954)3.44230359
32Arterial thrombosis (HP:0004420)3.42965594
33Increased IgE level (HP:0003212)3.37974273
34Spontaneous hematomas (HP:0007420)3.34725557
35Hemoptysis (HP:0002105)3.32661342
36Pulmonary infiltrates (HP:0002113)3.22430332
37Panhypogammaglobulinemia (HP:0003139)3.19671341
38Pulmonary embolism (HP:0002204)3.09335656
39Gingivitis (HP:0000230)3.07949230
40Cellulitis (HP:0100658)3.06199186
41Anorexia (HP:0002039)3.05586857
42Amyloidosis (HP:0011034)3.00535942
43Leukocytosis (HP:0001974)2.93993311
44Epistaxis (HP:0000421)2.91924393
45Peritonitis (HP:0002586)2.86470874
46Hepatosplenomegaly (HP:0001433)2.85152938
47Granulocytopenia (HP:0001913)2.75908179
48Gingival bleeding (HP:0000225)2.74608269
49Gangrene (HP:0100758)2.73247533
50Agammaglobulinemia (HP:0004432)2.69575908
51Inflammation of the large intestine (HP:0002037)2.68309252
52Abnormality of the pleura (HP:0002103)2.66834864
53Gastrointestinal inflammation (HP:0004386)2.63628465
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.63586085
55Abnormality of T cells (HP:0002843)2.57455488
56Petechiae (HP:0000967)2.57372658
57Recurrent viral infections (HP:0004429)2.56591850
58Abnormality of T cell physiology (HP:0011840)2.52004199
59Acute hepatic failure (HP:0006554)2.50158078
60Increased IgM level (HP:0003496)2.44200185
61Abnormality of the peritoneum (HP:0002585)2.42827293
62Abnormality of T cell number (HP:0011839)2.41833574
63Microcytic anemia (HP:0001935)2.39285206
64Increased cerebral lipofuscin (HP:0011813)2.37999898
65Osteomyelitis (HP:0002754)2.37617239
66T lymphocytopenia (HP:0005403)2.36273961
67Pustule (HP:0200039)2.34918725
68Eosinophilia (HP:0001880)2.32891332
69Sepsis (HP:0100806)2.31750700
70Colitis (HP:0002583)2.30443867
71Hypergammaglobulinemia (HP:0010702)2.27661190
72Glomerulopathy (HP:0100820)2.25638275
73Amaurosis fugax (HP:0100576)2.22499764
74Vertigo (HP:0002321)2.21248118
75Abnormality of the endocardium (HP:0004306)2.20739453
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.20550418
77Skin ulcer (HP:0200042)2.17008838
78Skin rash (HP:0000988)2.14046223
79Abnormality of the pericardium (HP:0001697)2.08522801
80Increased serum ferritin (HP:0003281)2.06909461
81Viral hepatitis (HP:0006562)2.06247726
82Abnormality of the prostate (HP:0008775)2.06228736
83Abnormality of iron homeostasis (HP:0011031)2.00311531
84Polyneuropathy (HP:0001271)1.99942818
85Thrombophlebitis (HP:0004418)1.99597560
86Autoimmune hemolytic anemia (HP:0001890)1.97714171
87Acne (HP:0001061)1.94762349
88Purpura (HP:0000979)1.92708321
89Hematochezia (HP:0002573)1.90485743
90Abnormal platelet volume (HP:0011876)1.89814515
91Abnormality of eosinophils (HP:0001879)1.88216646
92Chronic otitis media (HP:0000389)1.87768047
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85409619
94Hypertensive crisis (HP:0100735)1.85187561
95Upper motor neuron abnormality (HP:0002127)1.83874760
96Keratitis (HP:0000491)1.83865677
97Autoimmune thrombocytopenia (HP:0001973)1.83841084
98Lymphopenia (HP:0001888)1.82417469
99Hypermelanotic macule (HP:0001034)1.82345914
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.82296115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.73147260
2MAP4K13.65141357
3IRAK43.62627745
4FES3.33478844
5MAP2K33.13481818
6ERN12.88861108
7BLK2.79142464
8GRK62.74968535
9TYK22.66902658
10CSK2.54736088
11TNK22.52304231
12TESK22.26672959
13ZAP701.98402210
14BTK1.91793268
15MAP3K111.90291871
16HCK1.88268761
17EPHB11.88073664
18SYK1.87991151
19TAOK31.87554022
20KIT1.75508884
21JAK31.71677285
22FGR1.66125271
23TXK1.60684197
24MAP3K31.60057153
25TAOK11.59149024
26LYN1.51098948
27CSF1R1.50194973
28TBK11.50088395
29FRK1.48786245
30IKBKE1.45108193
31JAK21.39182939
32MAP3K141.38996980
33YES11.31877891
34PRPF4B1.24664570
35LCK1.24507756
36MAP3K11.19687081
37TEC1.14827288
38ITK1.13437103
39MAP3K131.11698553
40CDK191.06557918
41IRAK11.02998473
42SIK30.99147191
43JAK10.95543319
44BMPR20.95184078
45IRAK20.95021162
46MATK0.92848958
47IKBKB0.92822208
48MARK30.89014785
49KSR20.86653894
50MAP3K60.82633695
51PDK10.80926320
52PIK3CG0.79014779
53PTK2B0.76613808
54PTK60.75983891
55PRKD20.72807418
56MARK20.72710246
57STK110.70379969
58LRRK20.67896325
59DAPK20.67756488
60PDPK10.67320158
61SIK20.67310461
62FGFR30.67259459
63TAOK20.66223830
64FYN0.62569020
65MAPK120.61596008
66MAP3K70.59045437
67SMG10.58815708
68MAP2K40.56174547
69PRKCQ0.52970807
70HIPK20.52096305
71MAP3K50.51582690
72TLK10.51313630
73DYRK1B0.50970583
74RPS6KL10.50563493
75RPS6KC10.50563493
76MAP2K60.50222653
77STK100.49635541
78PIM10.45427351
79RPS6KA60.45130414
80PRKCD0.43279579
81MAPK70.42823046
82MAPKAPK20.39036468
83TGFBR20.38828945
84ABL10.36445286
85RAF10.35630547
86TRIB30.35607662
87KDR0.35583311
88MAP3K20.34412308
89PRKCZ0.33127122
90RET0.32633431
91ADRBK10.31474860
92GRK70.31432354
93BCKDK0.30602767
94EPHA30.29986784
95FGFR20.29130095
96SGK30.27856361
97TRPM70.26612144
98RPS6KA10.25176597
99CAMKK20.24853822
100CDC42BPA0.23119388

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.39687947
2Staphylococcus aureus infection_Homo sapiens_hsa051503.35835144
3Allograft rejection_Homo sapiens_hsa053303.19680750
4Graft-versus-host disease_Homo sapiens_hsa053323.10550003
5Autoimmune thyroid disease_Homo sapiens_hsa053202.95177743
6Osteoclast differentiation_Homo sapiens_hsa043802.77186593
7Asthma_Homo sapiens_hsa053102.58951912
8Type I diabetes mellitus_Homo sapiens_hsa049402.41990194
9Tuberculosis_Homo sapiens_hsa051522.31538818
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20642341
11Antigen processing and presentation_Homo sapiens_hsa046122.20239479
12Primary immunodeficiency_Homo sapiens_hsa053402.10607452
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06657431
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.06528764
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98912735
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98402345
17B cell receptor signaling pathway_Homo sapiens_hsa046621.89414565
18Hematopoietic cell lineage_Homo sapiens_hsa046401.88450511
19Malaria_Homo sapiens_hsa051441.86203921
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81569879
21Viral myocarditis_Homo sapiens_hsa054161.80222964
22Measles_Homo sapiens_hsa051621.64017261
23Legionellosis_Homo sapiens_hsa051341.60999289
24Influenza A_Homo sapiens_hsa051641.60495855
25Herpes simplex infection_Homo sapiens_hsa051681.57463216
26Toxoplasmosis_Homo sapiens_hsa051451.56052667
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54735396
28Other glycan degradation_Homo sapiens_hsa005111.50546230
29Phagosome_Homo sapiens_hsa041451.48842703
30Chemokine signaling pathway_Homo sapiens_hsa040621.48786030
31Acute myeloid leukemia_Homo sapiens_hsa052211.42901427
32African trypanosomiasis_Homo sapiens_hsa051431.41766630
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39419997
34Rheumatoid arthritis_Homo sapiens_hsa053231.36163894
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.32556015
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.30134562
37Platelet activation_Homo sapiens_hsa046111.24936630
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18502759
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17320570
40T cell receptor signaling pathway_Homo sapiens_hsa046601.16552182
41Pertussis_Homo sapiens_hsa051331.06961026
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03427673
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.02271003
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99787587
45TNF signaling pathway_Homo sapiens_hsa046680.95225353
46Shigellosis_Homo sapiens_hsa051310.94681138
47Salmonella infection_Homo sapiens_hsa051320.94010002
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93507966
49Hepatitis C_Homo sapiens_hsa051600.91286912
50Hepatitis B_Homo sapiens_hsa051610.88760492
51Non-small cell lung cancer_Homo sapiens_hsa052230.85521460
52Lysosome_Homo sapiens_hsa041420.83826648
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79846627
54Apoptosis_Homo sapiens_hsa042100.78821215
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78583190
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77252270
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76447961
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74343711
59VEGF signaling pathway_Homo sapiens_hsa043700.73676842
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.73073181
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69482662
62Arachidonic acid metabolism_Homo sapiens_hsa005900.60564355
63Epstein-Barr virus infection_Homo sapiens_hsa051690.60149496
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.60134804
65Endocytosis_Homo sapiens_hsa041440.60030197
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59482423
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.57648866
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.56849097
69Pancreatic cancer_Homo sapiens_hsa052120.56635795
70Chronic myeloid leukemia_Homo sapiens_hsa052200.55412507
71Prolactin signaling pathway_Homo sapiens_hsa049170.53924925
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50654066
73Notch signaling pathway_Homo sapiens_hsa043300.50318279
74Amoebiasis_Homo sapiens_hsa051460.49305557
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.46912258
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.46863076
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46424135
78Regulation of autophagy_Homo sapiens_hsa041400.46140176
79Dorso-ventral axis formation_Homo sapiens_hsa043200.45818425
80Choline metabolism in cancer_Homo sapiens_hsa052310.42913711
81FoxO signaling pathway_Homo sapiens_hsa040680.42522995
82Insulin resistance_Homo sapiens_hsa049310.41653819
83HTLV-I infection_Homo sapiens_hsa051660.38242409
84Viral carcinogenesis_Homo sapiens_hsa052030.37852587
85Systemic lupus erythematosus_Homo sapiens_hsa053220.37850973
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36415611
87Renal cell carcinoma_Homo sapiens_hsa052110.34642974
88GnRH signaling pathway_Homo sapiens_hsa049120.31363765
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29892004
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27936360
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27749241
92MAPK signaling pathway_Homo sapiens_hsa040100.26769311
93HIF-1 signaling pathway_Homo sapiens_hsa040660.26385609
94Endometrial cancer_Homo sapiens_hsa052130.24969625
95Ether lipid metabolism_Homo sapiens_hsa005650.24498633
96Collecting duct acid secretion_Homo sapiens_hsa049660.23730205
97mTOR signaling pathway_Homo sapiens_hsa041500.22148930
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21639584
99Inositol phosphate metabolism_Homo sapiens_hsa005620.20700804
100Type II diabetes mellitus_Homo sapiens_hsa049300.20369823

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