CEACAM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of smooth muscle cell differentiation (GO:0051151)9.54711679
2bundle of His cell to Purkinje myocyte communication (GO:0086069)8.46275384
3positive regulation of respiratory burst (GO:0060267)7.60839376
4gap junction assembly (GO:0016264)7.52197422
5labyrinthine layer development (GO:0060711)7.43354032
6glomerular filtration (GO:0003094)6.26541143
7maintenance of gastrointestinal epithelium (GO:0030277)6.02542488
8negative regulation of gluconeogenesis (GO:0045721)5.98331392
9parturition (GO:0007567)5.86119677
10regulation of transforming growth factor beta2 production (GO:0032909)5.83090644
11O-glycan processing (GO:0016266)5.78308923
12renal filtration (GO:0097205)5.76239030
13intestinal absorption (GO:0050892)5.72302947
14regulation of respiratory burst (GO:0060263)5.55524839
15purine nucleotide salvage (GO:0032261)5.43382067
16oligosaccharide biosynthetic process (GO:0009312)5.43282529
17trophectodermal cell differentiation (GO:0001829)5.24523938
18sulfate transmembrane transport (GO:1902358)5.08606890
19complement activation, classical pathway (GO:0006958)4.98379788
20ethanol oxidation (GO:0006069)4.95709105
21regulation of guanylate cyclase activity (GO:0031282)4.93214857
22placenta development (GO:0001890)4.82546027
23histone H4-K12 acetylation (GO:0043983)4.69421634
24bone morphogenesis (GO:0060349)4.67171597
25vitamin transmembrane transport (GO:0035461)4.57581117
26calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.55111348
27regulation of lipoprotein metabolic process (GO:0050746)4.52244314
28desmosome organization (GO:0002934)4.49408357
29positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.47174214
30mitotic G2 DNA damage checkpoint (GO:0007095)4.40756905
31epithelial structure maintenance (GO:0010669)4.38765459
32regulation of smooth muscle cell differentiation (GO:0051150)4.34581235
33regulation of macrophage chemotaxis (GO:0010758)4.33432120
34cellular glucuronidation (GO:0052695)4.25885593
35vascular endothelial growth factor signaling pathway (GO:0038084)4.24391844
36ethanol metabolic process (GO:0006067)4.22097960
37N-glycan processing (GO:0006491)4.20009943
38intestinal epithelial cell development (GO:0060576)4.17980773
39positive regulation of fatty acid beta-oxidation (GO:0032000)4.17555355
40antibacterial humoral response (GO:0019731)4.16881944
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.16209468
42receptor guanylyl cyclase signaling pathway (GO:0007168)4.13997828
43interferon-gamma secretion (GO:0072643)4.13785629
44regulation of cholesterol homeostasis (GO:2000188)4.12010748
45glucuronate metabolic process (GO:0019585)4.10738940
46uronic acid metabolic process (GO:0006063)4.10738940
47sulfate transport (GO:0008272)4.10241050
48antimicrobial humoral response (GO:0019730)4.08693458
49regulation of cellular extravasation (GO:0002691)4.08325122
50positive regulation of pseudopodium assembly (GO:0031274)4.04230689
51sperm capacitation (GO:0048240)4.04133572
52renal system process involved in regulation of blood volume (GO:0001977)4.03076089
53phospholipid homeostasis (GO:0055091)4.01047174
54embryonic process involved in female pregnancy (GO:0060136)3.97543675
55negative regulation of complement activation (GO:0045916)3.89630531
56complement activation (GO:0006956)3.87033024
57epithelial cell-cell adhesion (GO:0090136)3.84803581
58flavonoid metabolic process (GO:0009812)3.82865309
59regulation of vitamin metabolic process (GO:0030656)3.80257846
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.78228719
61regulation of tight junction assembly (GO:2000810)3.77768986
62basement membrane organization (GO:0071711)3.77379131
63auditory receptor cell differentiation (GO:0042491)3.73477614
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72762911
65cell junction maintenance (GO:0034331)3.70205834
66transcytosis (GO:0045056)3.70116954
67positive regulation of T cell differentiation in thymus (GO:0033089)3.69254252
68pyrimidine-containing compound transmembrane transport (GO:0072531)3.67542094
69ventricular cardiac muscle cell action potential (GO:0086005)3.67066910
70fucosylation (GO:0036065)3.63929887
71bile acid and bile salt transport (GO:0015721)3.61008812
72protein O-linked glycosylation (GO:0006493)3.60650560
73regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.59892657
74endocrine process (GO:0050886)3.59892657
75regulation of systemic arterial blood pressure by hormone (GO:0001990)3.59892657
76regulation of pseudopodium assembly (GO:0031272)3.59585731
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58553763
78embryonic digestive tract development (GO:0048566)3.57321359
79branching involved in salivary gland morphogenesis (GO:0060445)3.56938489
80digestive system process (GO:0022600)3.52472612
81actin filament depolymerization (GO:0030042)3.51328228
82bicarbonate transport (GO:0015701)3.49885258
83negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.48878994
84GDP-mannose metabolic process (GO:0019673)3.48271474
85glucocorticoid biosynthetic process (GO:0006704)3.47178462
86lung epithelium development (GO:0060428)3.46661012
87labyrinthine layer blood vessel development (GO:0060716)3.46233369
88negative regulation of protein activation cascade (GO:2000258)3.42979543
89diterpenoid biosynthetic process (GO:0016102)3.38055326
90regulation of viral release from host cell (GO:1902186)3.35004536
91UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34520489
92neuron projection extension involved in neuron projection guidance (GO:1902284)3.34042627
93axon extension involved in axon guidance (GO:0048846)3.34042627
94diaphragm development (GO:0060539)3.30082622
95primary alcohol catabolic process (GO:0034310)3.28302429
96hippo signaling (GO:0035329)3.27864377
97multicellular organismal water homeostasis (GO:0050891)3.26327704
98plasma membrane repair (GO:0001778)3.25393565
99nucleotide-sugar biosynthetic process (GO:0009226)3.25196102
100eosinophil chemotaxis (GO:0048245)3.24907126
101regulation of hair follicle development (GO:0051797)3.24816950
102positive regulation of guanylate cyclase activity (GO:0031284)3.24406430
103endocardial cushion development (GO:0003197)3.23188235
104angiotensin maturation (GO:0002003)3.23157938
105sodium ion homeostasis (GO:0055078)3.21044001
106auditory behavior (GO:0031223)3.20797611
107blood vessel maturation (GO:0001955)3.19642759
108antigen processing and presentation of endogenous antigen (GO:0019883)3.19264670
109adherens junction organization (GO:0034332)3.18268413
110regulation of systemic arterial blood pressure (GO:0003073)3.18117873
111receptor recycling (GO:0001881)3.17769811
112ear development (GO:0043583)3.16869300
113positive regulation of fatty acid oxidation (GO:0046321)3.16025067
114mitotic G2/M transition checkpoint (GO:0044818)3.13538168
115lung vasculature development (GO:0060426)3.11699181
116positive regulation of monooxygenase activity (GO:0032770)3.10924048
117positive regulation of Cdc42 GTPase activity (GO:0043089)3.09168047
118lens morphogenesis in camera-type eye (GO:0002089)3.08311273
119sequestering of metal ion (GO:0051238)3.07253323
120cell communication involved in cardiac conduction (GO:0086065)3.05923314
121toxin transport (GO:1901998)3.04342195
122positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.03583962
123negative regulation of leukocyte chemotaxis (GO:0002689)3.03436880
124skeletal muscle organ development (GO:0060538)3.01368765
125regulation of intracellular pH (GO:0051453)2.99598790
126response to lipoprotein particle (GO:0055094)2.99140220
127striated muscle atrophy (GO:0014891)2.95387698
128cGMP-mediated signaling (GO:0019934)2.93302036
129regulation of cGMP biosynthetic process (GO:0030826)2.92983706
130adrenal gland development (GO:0030325)2.92370311
131thrombin receptor signaling pathway (GO:0070493)2.91330240
132activin receptor signaling pathway (GO:0032924)2.91210592
133excretion (GO:0007588)2.91195731
134protein activation cascade (GO:0072376)2.91013212
135urea cycle (GO:0000050)2.90381543
136regulation of hippo signaling (GO:0035330)2.89823511
137regulation of heart rate by cardiac conduction (GO:0086091)2.87918446
138eosinophil migration (GO:0072677)2.87740557
139negative regulation of epidermis development (GO:0045683)2.87682004
140histamine transport (GO:0051608)2.87458599
141lipid translocation (GO:0034204)2.87177811
142phospholipid translocation (GO:0045332)2.87177811
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.86134054
144positive regulation of dendrite morphogenesis (GO:0050775)2.85917760
145arginine catabolic process (GO:0006527)2.85010847
146sodium-independent organic anion transport (GO:0043252)2.84692456
147cell junction assembly (GO:0034329)2.84188109
148renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.82181724
149positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.81902810
150positive regulation of Rho protein signal transduction (GO:0035025)2.81508935
151retina homeostasis (GO:0001895)2.80399546
152nucleoside diphosphate biosynthetic process (GO:0009133)2.79072130
153epoxygenase P450 pathway (GO:0019373)2.76319180
154cellular response to pH (GO:0071467)2.75229376
155purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.74972480
1563-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.74972480
157L-fucose catabolic process (GO:0042355)2.74371629
158fucose catabolic process (GO:0019317)2.74371629
159L-fucose metabolic process (GO:0042354)2.74371629
160sulfur compound transport (GO:0072348)2.74341633
161regulation of cholesterol storage (GO:0010885)2.74251285
162histone H2A monoubiquitination (GO:0035518)2.74127098
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.73392169
164drug transmembrane transport (GO:0006855)2.72662207
1654-hydroxyproline metabolic process (GO:0019471)2.72498647
166high-density lipoprotein particle remodeling (GO:0034375)2.71954454
167protein heterotrimerization (GO:0070208)2.71622970
168regulation of cellular pH (GO:0030641)2.71306684
169polarized epithelial cell differentiation (GO:0030859)2.70753515
170regulation of podosome assembly (GO:0071801)2.70518684
171water homeostasis (GO:0030104)2.70412954
172cell differentiation involved in embryonic placenta development (GO:0060706)2.70202587
173regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.69616518
174response to food (GO:0032094)2.69355274
175urea metabolic process (GO:0019627)2.67934482
176COPI coating of Golgi vesicle (GO:0048205)2.67009527
177Golgi transport vesicle coating (GO:0048200)2.67009527
178positive regulation of cellular response to insulin stimulus (GO:1900078)2.66978026
179positive regulation of cell size (GO:0045793)2.65988607
180cell junction organization (GO:0034330)2.65944268
181macroautophagy (GO:0016236)2.65745364
182negative regulation of activin receptor signaling pathway (GO:0032926)2.64802923
183lipoprotein transport (GO:0042953)2.64173349
184response to parathyroid hormone (GO:0071107)2.63913472
185cell-cell junction assembly (GO:0007043)2.63829442
186substrate adhesion-dependent cell spreading (GO:0034446)2.63361338
187vitamin transport (GO:0051180)2.62317664
188neuronal stem cell maintenance (GO:0097150)2.61934345
189nodal signaling pathway (GO:0038092)2.60099577
190embryonic placenta development (GO:0001892)2.59814646
191L-alpha-amino acid transmembrane transport (GO:1902475)2.58636189
192semaphorin-plexin signaling pathway (GO:0071526)2.58527923
193negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.58189249
194regulation of G0 to G1 transition (GO:0070316)10.0654731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX2_27498859_Chip-Seq_STOMACH_Mouse3.35929062
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.29758151
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.23990048
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.23163660
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09185058
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.85768501
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.75277397
8SALL4_18804426_ChIP-ChIP_XEN_Mouse2.74492793
9ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.65535872
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.60295222
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47519526
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46817663
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.36887584
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15633212
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12008413
16SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.07677315
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.07271795
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04985817
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.04128579
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.03134173
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse10.7162834
22ZNF263_19887448_ChIP-Seq_K562_Human1.99226464
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96758229
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.83452493
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77500319
26KLF5_25053715_ChIP-Seq_YYC3_Human1.75852515
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.75371203
28DROSHA_22980978_ChIP-Seq_HELA_Human1.75282138
29CLOCK_20551151_ChIP-Seq_293T_Human1.73288047
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73040781
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65629364
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.64071609
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62949482
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62529078
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59370185
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.58076185
37SOX2_20726797_ChIP-Seq_SW620_Human1.55763780
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.52983006
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.52678130
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46945103
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.46765781
42AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.46322414
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46103498
44TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46020900
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45867867
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44026709
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43350708
48KDM2B_26808549_Chip-Seq_K562_Human1.42299555
49RACK7_27058665_Chip-Seq_MCF-7_Human1.39808852
50AHR_22903824_ChIP-Seq_MCF-7_Human1.36454416
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35748444
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35531052
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35403608
54FOXA1_25552417_ChIP-Seq_VCAP_Human1.33525187
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32385114
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32239440
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30051472
58GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.26551200
59RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26233334
60EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25618156
61CDX2_22108803_ChIP-Seq_LS180_Human1.24676141
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24617279
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22868546
64GATA1_19941826_ChIP-Seq_K562_Human1.21218879
65EGR1_19032775_ChIP-ChIP_M12_Human1.19003045
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18235830
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17732039
68GATA4_25053715_ChIP-Seq_YYC3_Human1.15490402
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.15482967
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15411426
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15160413
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13855372
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12522867
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11992823
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.11095659
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11048891
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09221527
78LXR_22292898_ChIP-Seq_THP-1_Human1.09113877
79ZNF274_21170338_ChIP-Seq_K562_Hela1.07279601
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05944431
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05929856
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05104081
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04617965
84AR_21572438_ChIP-Seq_LNCaP_Human1.04253557
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03932661
86* CDX2_20551321_ChIP-Seq_CACO-2_Human1.03049860
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02882892
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02668010
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02532112
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02374445
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.01444182
92CEBPB_22108803_ChIP-Seq_LS180_Human0.99902235
93FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97470733
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97178337
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97167847
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.97042014
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96978383
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.96794625
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.96794625
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95310939
101GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94413092
102HNF4A_19822575_ChIP-Seq_HepG2_Human0.94162906
103GATA2_19941826_ChIP-Seq_K562_Human0.94112919
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93129478
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92977698
106FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91819449
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91708558
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91592512
109* ESET_19884257_ChIP-Seq_ESCs_Mouse0.91493760
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91193596
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91193596
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90938790
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90938790
114SCL_19346495_ChIP-Seq_HPC-7_Human0.90434114
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89752935
116TP63_23658742_ChIP-Seq_EP156T_Human0.89245739
117GATA3_24758297_ChIP-Seq_MCF-7_Human0.88353305
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87424198
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86761379
120GATA6_25053715_ChIP-Seq_YYC3_Human0.85464503
121KDM2B_26808549_Chip-Seq_DND41_Human0.84442007
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84338951
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84228117
124LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83629313
125TP63_22573176_ChIP-Seq_HFKS_Human0.83387341
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83212691
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.82720497
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82690716
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82482107
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81035058
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80891167
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80827661
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80735292
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.80505477
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80003106
136CJUN_26792858_Chip-Seq_BT549_Human0.79685729
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.79492977
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79389692
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78894998
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78846362
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78537173
142SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77864767
143SPI1_23127762_ChIP-Seq_K562_Human0.77149939
144IRF8_27001747_Chip-Seq_BMDM_Mouse0.74577068
145STAT1_20625510_ChIP-Seq_HELA_Human0.74243547
146CREB1_26743006_Chip-Seq_LNCaP_Human0.72143259
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71525011
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71169849
149AR_21909140_ChIP-Seq_LNCAP_Human0.70717678
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69031993
151KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68779498
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.68043222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.43629182
2MP0002139_abnormal_hepatobiliary_system4.91563610
3MP0000013_abnormal_adipose_tissue4.90868284
4MP0004272_abnormal_basement_membrane4.89232863
5MP0004264_abnormal_extraembryonic_tissu4.80684563
6MP0003122_maternal_imprinting4.21174928
7MP0005187_abnormal_penis_morphology3.82807212
8MP0001661_extended_life_span3.80164440
9MP0003123_paternal_imprinting3.79747977
10MP0003866_abnormal_defecation3.65638434
11MP0010352_gastrointestinal_tract_polyps3.60204162
12MP0003566_abnormal_cell_adhesion3.52548876
13MP0004043_abnormal_pH_regulation3.52428998
14MP0010155_abnormal_intestine_physiology3.22476753
15MP0003121_genomic_imprinting3.09178145
16MP0008775_abnormal_heart_ventricle2.99252718
17MP0005670_abnormal_white_adipose2.96147543
18MP0005085_abnormal_gallbladder_physiolo2.72077579
19MP0001664_abnormal_digestion2.57395627
20MP0004885_abnormal_endolymph2.47921560
21MP0001663_abnormal_digestive_system2.45755788
22MP0000477_abnormal_intestine_morphology2.42674072
23MP0001666_abnormal_nutrient_absorption2.29373043
24MP0004782_abnormal_surfactant_physiolog2.28766288
25MP0004147_increased_porphyrin_level2.26051646
26MP0003705_abnormal_hypodermis_morpholog2.23882813
27MP0001873_stomach_inflammation2.22252697
28MP0000490_abnormal_crypts_of2.19371360
29MP0005381_digestive/alimentary_phenotyp2.13095899
30MP0001765_abnormal_ion_homeostasis2.11798419
31MP0000003_abnormal_adipose_tissue2.10121245
32MP0009379_abnormal_foot_pigmentation2.08896373
33MP0004185_abnormal_adipocyte_glucose2.03992157
34MP0002796_impaired_skin_barrier1.95266642
35MP0005360_urolithiasis1.94069555
36MP0005076_abnormal_cell_differentiation1.83267944
37MP0005164_abnormal_response_to1.81921448
38MP0000647_abnormal_sebaceous_gland1.81807427
39MP0004197_abnormal_fetal_growth/weight/1.80008270
40MP0003183_abnormal_peptide_metabolism1.77606489
41MP0003868_abnormal_feces_composition1.76138004
42MP0003091_abnormal_cell_migration1.74771730
43MP0002877_abnormal_melanocyte_morpholog1.70861695
44MP0005166_decreased_susceptibility_to1.69596006
45MP0008438_abnormal_cutaneous_collagen1.69422434
46MP0005623_abnormal_meninges_morphology1.69240480
47MP0005409_darkened_coat_color1.66883818
48MP0002098_abnormal_vibrissa_morphology1.66138226
49MP0002138_abnormal_hepatobiliary_system1.59815254
50MP0002086_abnormal_extraembryonic_tissu1.57690379
51MP0000343_altered_response_to1.54480120
52MP0004883_abnormal_blood_vessel1.52256237
53MP0009384_cardiac_valve_regurgitation1.49232747
54MP0000639_abnormal_adrenal_gland1.42776595
55MP0000678_abnormal_parathyroid_gland1.41025343
56MP0005636_abnormal_mineral_homeostasis1.39619166
57MP0002876_abnormal_thyroid_physiology1.36582327
58MP0003724_increased_susceptibility_to1.35624757
59MP0008004_abnormal_stomach_pH1.33840547
60MP0000462_abnormal_digestive_system1.30271188
61MP0002166_altered_tumor_susceptibility1.28498015
62MP0005310_abnormal_salivary_gland1.26905172
63MP0000579_abnormal_nail_morphology1.26482381
64MP0001915_intracranial_hemorrhage1.26271361
65MP0005248_abnormal_Harderian_gland1.25134966
66MP0010678_abnormal_skin_adnexa1.24096043
67MP0004858_abnormal_nervous_system1.24091111
68MP0010329_abnormal_lipoprotein_level1.21288203
69MP0000383_abnormal_hair_follicle1.20128942
70MP0001881_abnormal_mammary_gland1.17361364
71MP0006276_abnormal_autonomic_nervous1.17308279
72MP0008875_abnormal_xenobiotic_pharmacok1.16813700
73MP0002653_abnormal_ependyma_morphology1.16620250
74MP0003984_embryonic_growth_retardation1.15344488
75MP0004019_abnormal_vitamin_homeostasis1.14378170
76MP0009643_abnormal_urine_homeostasis1.12785269
77MP0000566_synostosis1.12350652
78MP0002009_preneoplasia1.11079333
79MP0002088_abnormal_embryonic_growth/wei1.09804843
80MP0005375_adipose_tissue_phenotype1.08725033
81MP0003303_peritoneal_inflammation1.06855582
82MP0009785_altered_susceptibility_to1.06442095
83MP0000467_abnormal_esophagus_morphology1.05371824
84MP0004947_skin_inflammation1.05021111
85MP0003453_abnormal_keratinocyte_physiol1.04226998
86MP0002136_abnormal_kidney_physiology1.02653170
87MP0003045_fibrosis0.99862247
88MP0003567_abnormal_fetal_cardiomyocyte0.99247862
89MP0010234_abnormal_vibrissa_follicle0.99186882
90MP0004084_abnormal_cardiac_muscle0.99181982
91MP0005023_abnormal_wound_healing0.98843799
92MP0001216_abnormal_epidermal_layer0.98085321
93MP0002006_tumorigenesis0.97471439
94MP0005025_abnormal_response_to0.96812627
95MP0000230_abnormal_systemic_arterial0.95674672
96MP0003191_abnormal_cellular_cholesterol0.94847652
97MP0001849_ear_inflammation0.94752576
98MP0003632_abnormal_nervous_system0.93806313
99MP0002128_abnormal_blood_circulation0.93491712
100MP0001485_abnormal_pinna_reflex0.93242759
101MP0000470_abnormal_stomach_morphology0.92130043
102MP0005501_abnormal_skin_physiology0.90611323
103MP0003329_amyloid_beta_deposits0.87504054
104MP0001845_abnormal_inflammatory_respons0.84890594
105MP0005451_abnormal_body_composition0.82864872
106MP0003283_abnormal_digestive_organ0.82762074
107MP0001672_abnormal_embryogenesis/_devel0.82442776
108MP0005380_embryogenesis_phenotype0.82442776
109MP0001790_abnormal_immune_system0.82296569
110MP0005387_immune_system_phenotype0.82296569
111MP0002971_abnormal_brown_adipose0.81909989
112MP0002060_abnormal_skin_morphology0.80379890
113MP0003279_aneurysm0.80224036
114MP0002254_reproductive_system_inflammat0.79782560
115MP0004510_myositis0.79210791
116MP0010630_abnormal_cardiac_muscle0.78575098
117MP0009333_abnormal_splenocyte_physiolog0.78115620
118MP0008872_abnormal_physiological_respon0.77891955
119MP0005275_abnormal_skin_tensile0.77589419
120MP0004859_abnormal_synaptic_plasticity0.76985664
121MP0000377_abnormal_hair_follicle0.76761775
122MP0005058_abnormal_lysosome_morphology0.76741059
123MP0006082_CNS_inflammation0.76587846
124MP0005319_abnormal_enzyme/_coenzyme0.76005171
125MP0002925_abnormal_cardiovascular_devel0.75642841
126MP0005666_abnormal_adipose_tissue0.75339864
127MP0003879_abnormal_hair_cell0.75085061
128MP0005595_abnormal_vascular_smooth0.74346356
129MP0009697_abnormal_copulation0.73517985
130MP0005083_abnormal_biliary_tract0.72107971
131MP0003638_abnormal_response/metabolism_0.71804277
132MP0001544_abnormal_cardiovascular_syste0.71782391
133MP0005385_cardiovascular_system_phenoty0.71782391
134MP0002896_abnormal_bone_mineralization0.71442235
135MP0005171_absent_coat_pigmentation0.71335739
136MP0004130_abnormal_muscle_cell0.71081359
137MP0000427_abnormal_hair_cycle0.70255265
138MP0002998_abnormal_bone_remodeling0.70184223
139MP0000604_amyloidosis0.69762169
140MP0002822_catalepsy0.69535858
141MP0001188_hyperpigmentation0.68285868
142MP0000465_gastrointestinal_hemorrhage0.67922649
143MP0000858_altered_metastatic_potential0.67566816
144MP0000249_abnormal_blood_vessel0.66821257
145MP0001835_abnormal_antigen_presentation0.66599235
146MP0003119_abnormal_digestive_system0.66513833
147MP0001756_abnormal_urination0.66099753
148MP0003436_decreased_susceptibility_to0.66037429
149MP0009840_abnormal_foam_cell0.66037026
150MP0006138_congestive_heart_failure0.64658684
151MP0001614_abnormal_blood_vessel0.64521951
152MP0001533_abnormal_skeleton_physiology0.64317765
153MP0004036_abnormal_muscle_relaxation0.63201489
154MP0002148_abnormal_hypersensitivity_rea0.62995786
155MP0000627_abnormal_mammary_gland0.62384407
156MP0002132_abnormal_respiratory_system0.62005391
157MP0003300_gastrointestinal_ulcer0.60933043
158MP0002118_abnormal_lipid_homeostasis0.60739170
159MP0005257_abnormal_intraocular_pressure0.59483958
160MP0004133_heterotaxia0.58986250
161MP0001800_abnormal_humoral_immune0.58863601
162MP0004484_altered_response_of0.58349196
163MP0001502_abnormal_circadian_rhythm0.58055060
164MP0003011_delayed_dark_adaptation0.57853293
165MP0004087_abnormal_muscle_fiber0.56566252
166MP0003252_abnormal_bile_duct0.55254159
167MP0000266_abnormal_heart_morphology0.55064672
168MP0000767_abnormal_smooth_muscle0.54336201
169MP0005165_increased_susceptibility_to0.53940766
170MP0000609_abnormal_liver_physiology0.53905074
171MP0001177_atelectasis0.53884396
172MP0000537_abnormal_urethra_morphology0.53828445
173MP0005365_abnormal_bile_salt0.53744903

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)9.83669461
2Right ventricular cardiomyopathy (HP:0011663)8.83201901
3Decreased circulating renin level (HP:0003351)6.93010011
4Abnormality of renin-angiotensin system (HP:0000847)6.50277668
5Metabolic alkalosis (HP:0200114)6.14602199
6Pili torti (HP:0003777)6.11511811
7Alopecia of scalp (HP:0002293)5.92871155
8Abnormality of chloride homeostasis (HP:0011422)5.55434172
9Flat acetabular roof (HP:0003180)5.21103339
10Hyperaldosteronism (HP:0000859)4.95016841
11Alkalosis (HP:0001948)4.60951372
12Autoamputation (HP:0001218)4.57867557
13Polyphagia (HP:0002591)4.57143051
14Abnormality of the diencephalon (HP:0010662)4.54151798
15Abnormality of monocarboxylic acid metabolism (HP:0010996)4.46665537
16Selective tooth agenesis (HP:0001592)4.42332381
17Woolly hair (HP:0002224)4.16682338
18Ileus (HP:0002595)4.14498315
19Oral leukoplakia (HP:0002745)4.10360902
20Abnormal pancreas size (HP:0012094)4.06248719
21Malnutrition (HP:0004395)4.03464094
22Hyponatremia (HP:0002902)3.89324971
23Absent eyelashes (HP:0000561)3.89222115
24Hyperkalemia (HP:0002153)3.80298901
25Abnormal hair laboratory examination (HP:0003328)3.77547049
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.75992985
27Intrahepatic cholestasis (HP:0001406)3.61406980
28Systemic lupus erythematosus (HP:0002725)3.53804717
29Mesangial abnormality (HP:0001966)3.52151443
30Hemorrhage of the eye (HP:0011885)3.49961803
31Recurrent corneal erosions (HP:0000495)3.47492325
32Conjugated hyperbilirubinemia (HP:0002908)3.42433965
33Chronic bronchitis (HP:0004469)3.40786017
34Autoimmune thrombocytopenia (HP:0001973)3.37914291
35Sparse eyelashes (HP:0000653)3.36190392
36Villous atrophy (HP:0011473)3.33376520
37Abnormality of small intestinal villus morphology (HP:0011472)3.33376520
38Abdominal distention (HP:0003270)3.27701531
39Abnormality of the distal phalanx of the thumb (HP:0009617)3.26002530
40Abnormality of potassium homeostasis (HP:0011042)3.23617678
41Multifactorial inheritance (HP:0001426)3.21244146
42Abnormality of placental membranes (HP:0011409)3.19559322
43Amniotic constriction ring (HP:0009775)3.19559322
44Hypokalemia (HP:0002900)3.12914604
45Chronic diarrhea (HP:0002028)3.12208094
46Neonatal short-limb short stature (HP:0008921)3.03986183
47Hyporeflexia of lower limbs (HP:0002600)3.02658318
48Abnormality of nail color (HP:0100643)2.99639031
49Hypoalphalipoproteinemia (HP:0003233)2.99348445
50Abnormal tarsal ossification (HP:0008369)2.97140000
51Cervical subluxation (HP:0003308)2.94258972
52Annular pancreas (HP:0001734)2.94157711
53Abnormality of sodium homeostasis (HP:0010931)2.92261082
54Congenital sensorineural hearing impairment (HP:0008527)2.90786920
55Delayed puberty (HP:0000823)2.88905182
56Flattened epiphyses (HP:0003071)2.87366702
57Shallow orbits (HP:0000586)2.86913246
58Polycythemia (HP:0001901)2.86234374
59Polygenic inheritance (HP:0010982)2.80895410
60Abnormality of the nasal mucosa (HP:0000433)2.77003581
61Erythroderma (HP:0001019)2.73039352
62Recurrent bacterial skin infections (HP:0005406)2.72037213
63Abnormal biliary tract morphology (HP:0012440)2.71520295
64Deep venous thrombosis (HP:0002625)2.65956425
65Hypotrichosis (HP:0001006)2.63281631
66Keratoconjunctivitis sicca (HP:0001097)2.61844702
67Distal upper limb amyotrophy (HP:0007149)2.61245255
68Upper limb amyotrophy (HP:0009129)2.61245255
69Fat malabsorption (HP:0002630)2.59927126
70Adrenal overactivity (HP:0002717)2.54557713
71Oligomenorrhea (HP:0000876)2.50133902
72Eczematoid dermatitis (HP:0000976)2.48074337
73Turricephaly (HP:0000262)2.47993109
74Muscle fiber splitting (HP:0003555)2.46721214
75Cupped ribs (HP:0000887)2.46622633
76Cerebral inclusion bodies (HP:0100314)2.45727118
77Abnormal eating behavior (HP:0100738)2.44895445
78Dehydration (HP:0001944)2.43005294
79Abnormality of the 1st metacarpal (HP:0010009)2.42664740
80Increased IgE level (HP:0003212)2.40256660
81Abnormality of complement system (HP:0005339)2.35256690
82Renal salt wasting (HP:0000127)2.34803747
83Abnormality of carpal bone ossification (HP:0006257)2.33905789
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33575006
85Complement deficiency (HP:0004431)2.33511425
86Glomerulonephritis (HP:0000099)2.33279757
87Palpitations (HP:0001962)2.32260057
88Abnormality of the aortic arch (HP:0012303)2.30745401
89Hyperuricemia (HP:0002149)2.30054405
90Increased purine levels (HP:0004368)2.30054405
91Keratoconjunctivitis (HP:0001096)2.29575760
92Esophageal varix (HP:0002040)2.27386132
93Spinal cord compression (HP:0002176)2.27019330
94Cerebral aneurysm (HP:0004944)2.26014354
95Ventricular fibrillation (HP:0001663)2.23874069
96Hypotension (HP:0002615)2.23564870
97Abnormal vertebral ossification (HP:0100569)2.22203400
98Mildly elevated creatine phosphokinase (HP:0008180)2.21652888
99Premature rupture of membranes (HP:0001788)2.20723527
100Bronchitis (HP:0012387)2.20638054
101Urinary glycosaminoglycan excretion (HP:0003541)2.17581212
102Mucopolysacchariduria (HP:0008155)2.17581212
103Nasal polyposis (HP:0100582)2.16976131
104Premature loss of primary teeth (HP:0006323)2.16704321
105Nephritis (HP:0000123)2.16588888
106Muscle fibrillation (HP:0010546)2.16035544
107Axonal loss (HP:0003447)2.15600393
108Neurofibrillary tangles (HP:0002185)2.14851948
109Biliary tract neoplasm (HP:0100574)2.13917940
110Vertebral hypoplasia (HP:0008417)2.13766815
111Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13766815
112Cortical dysplasia (HP:0002539)2.12873940
113Curly hair (HP:0002212)2.10707305
114Abnormality of the vitamin B12 metabolism (HP:0004341)2.10135672
115Bronchiectasis (HP:0002110)2.09883266
116Abnormality of the gastric mucosa (HP:0004295)2.08726116
117Asymmetric septal hypertrophy (HP:0001670)2.07618623
118Syncope (HP:0001279)2.07434441
119Hydroxyprolinuria (HP:0003080)2.07430076
120Abnormality of proline metabolism (HP:0010907)2.07430076
121Relative macrocephaly (HP:0004482)2.07289424
122Autoimmune hemolytic anemia (HP:0001890)2.07181481
123Flat capital femoral epiphysis (HP:0003370)2.05336688
124Knee flexion contracture (HP:0006380)2.05159148
125Hand muscle atrophy (HP:0009130)2.04951898
126Widely spaced teeth (HP:0000687)2.03910261
127Abnormal foot bone ossification (HP:0010675)2.03827235
128Asymmetry of the thorax (HP:0001555)2.01925116
129Bilateral microphthalmos (HP:0007633)2.01296602
130Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00905683
131Abnormality of polysaccharide metabolism (HP:0011012)2.00905683
132Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00905683
133Growth hormone deficiency (HP:0000824)1.99630509
134Toxemia of pregnancy (HP:0100603)1.98017007
135Epiphyseal dysplasia (HP:0002656)1.97413277
136Abnormality of vitamin metabolism (HP:0100508)1.95425428
137Focal segmental glomerulosclerosis (HP:0000097)1.92889450
138Confusion (HP:0001289)1.92063998
139Hyperparathyroidism (HP:0000843)1.91329846
140Hoarse voice (HP:0001609)1.90805050
141Abnormality of vitamin B metabolism (HP:0004340)1.90787337
142Severe short stature (HP:0003510)1.90671783
143Enlarged penis (HP:0000040)1.90281373
144Difficulty climbing stairs (HP:0003551)1.89897215
145Increased cerebral lipofuscin (HP:0011813)1.89386918
146Colitis (HP:0002583)1.87184849
147Hypoplastic toenails (HP:0001800)1.86995352
148Hyperacusis (HP:0010780)1.85581531
149Abnormal hand bone ossification (HP:0010660)1.85145411
150Micronodular cirrhosis (HP:0001413)1.85144048
151Late onset (HP:0003584)1.84248460
152Thin bony cortex (HP:0002753)1.84025872
153Hyperphosphatemia (HP:0002905)1.82384791
154Glomerulosclerosis (HP:0000096)1.82178901
155Resting tremor (HP:0002322)1.81397521
156Short phalanx of the thumb (HP:0009660)1.80784396
157Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.80614665
158Inflammation of the large intestine (HP:0002037)1.79421031
159Visceral angiomatosis (HP:0100761)1.79087929
160Hypoplasia of the uterus (HP:0000013)1.78912530
161Abnormal ossification of hand bones (HP:0005921)1.78160289
162Hypolipoproteinemia (HP:0010981)1.78052747
163Vertebral clefting (HP:0008428)1.77485840
164Spastic diplegia (HP:0001264)1.76657715
165Rectal prolapse (HP:0002035)1.75826493
166Periodontitis (HP:0000704)1.75698376
167Abnormal cartilage morphology (HP:0002763)1.74705519
168B lymphocytopenia (HP:0010976)1.73924884
169Abnormality of B cell number (HP:0010975)1.73924884
170Increased connective tissue (HP:0009025)1.73846283
171Difficulty running (HP:0009046)1.73522521
172Aneurysm (HP:0002617)1.71283799
173Hyperammonemia (HP:0001987)1.71247083
174Bronchomalacia (HP:0002780)1.70955573
175Abnormal hemoglobin (HP:0011902)1.70948573
176Hemiplegia (HP:0002301)1.70373769
177Tetraparesis (HP:0002273)1.70255023
178Breech presentation (HP:0001623)1.70121432
179Increased variability in muscle fiber diameter (HP:0003557)1.68492186
180Fragile skin (HP:0001030)1.68357724
181Conjunctival telangiectasia (HP:0000524)1.68318145
182Abnormality of the phalanges of the hallux (HP:0010057)1.66892988
183Cardiomegaly (HP:0001640)1.66619955
184Cone-rod dystrophy (HP:0000548)1.66335623
185Gastrointestinal inflammation (HP:0004386)1.66089300
186Purpura (HP:0000979)1.66003099
187Hemangiomatosis (HP:0007461)1.65450365
188Ventricular tachycardia (HP:0004756)1.64710565
189Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64369110
190Renal tubular acidosis (HP:0001947)1.63868074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.51083304
2EPHA26.16870209
3TRIB34.68989198
4LMTK24.57109934
5PKN24.57066536
6PIK3CA4.49600862
7ACVR1B3.54043980
8STK393.38197573
9PDGFRA3.08006603
10PTK62.69108134
11EPHB12.58082168
12RET2.51626473
13LATS22.46479849
14RPS6KB22.38632959
15FER2.33790180
16MST42.28393161
17LRRK22.25867475
18AKT22.18477576
19OXSR12.14196750
20ERN12.08860258
21MAPKAPK32.00699428
22DDR21.94029328
23STK241.84445887
24MAP2K11.79119065
25FGFR41.75465382
26DAPK21.70417025
27PLK41.61536959
28MARK31.59780532
29PAK41.59641080
30EPHA31.56052720
31CDK91.52579226
32PTK21.50417527
33LATS11.48031134
34TYRO31.39466370
35MAP3K91.39340500
36PDGFRB1.37815403
37BMX1.35428704
38PDPK11.28692172
39MAPKAPK51.26697910
40KSR11.25450680
41MATK1.22146300
42EPHB21.17916592
43KSR21.17320145
44CDC42BPA1.16270752
45PRKG21.14077137
46STK101.11994736
47TAOK31.10454606
48SGK11.06758491
49TYK21.04318145
50FGFR11.04019256
51MAP2K41.03843720
52ARAF1.02847887
53PTK2B1.02036993
54FGR1.01684490
55PAK31.01489599
56MAP3K101.00025002
57MET0.99896345
58LIMK10.99476467
59FGFR30.95487039
60EEF2K0.94897668
61ALK0.94594294
62PDK10.90772453
63PRKCI0.89838298
64MAP3K10.89717762
65CSK0.86844634
66ERBB20.85769737
67RIPK10.85468099
68MAP3K120.84632903
69MAP3K20.83840759
70MINK10.83577589
71ROCK10.79583131
72TESK10.79244358
73MYLK0.79018282
74MTOR0.78903007
75MAP3K30.76502773
76SCYL20.75064055
77MAP2K60.74621640
78TBK10.74278010
79PRKD10.73669526
80NLK0.71600861
81PRKAA20.71528442
82TAOK10.71378339
83ZAP700.70335953
84WNK40.69929470
85MAPK110.69247515
86STK380.67174621
87WNK30.65576567
88ABL20.64396915
89BLK0.64049767
90CAMKK10.63945832
91WNK10.63792247
92RIPK40.63005627
93GSK3A0.62507454
94MAPK90.61698004
95MAP3K130.61352371
96PRPF4B0.60417658
97PLK20.58143703
98ROCK20.57856893
99NME10.57188208
100SRC0.56673689
101MAP2K20.56484361
102TRPM70.56037923
103CAMK2D0.52300400
104YES10.51750595
105SMG10.50233950
106EGFR0.50187347
107MAP3K140.50042533
108DMPK0.49952725
109IRAK10.49741918
110CASK0.49010209
111MAPK150.48603455
112ILK0.47856671
113PRKCH0.46742433
114TESK20.46660391
115KIT0.43671744
116ITK0.43621436
117IGF1R0.43147496
118MAPK80.42784913
119INSR0.41457689
120PRKCE0.40669935
121PDK20.39773734
122MAP3K80.39592107
123CDK50.39142639
124JAK10.38585694
125CSNK1A1L0.38100602
126MAP3K70.38064758
127TTN0.38049452
128CDK60.34985422
129NTRK10.34941427
130BCR0.34767234
131ABL10.33179464
132GRK60.32131266
133NEK60.30874233
134NEK90.30587814
135KDR0.29322720
136NEK10.29284043
137FYN0.29278881
138SIK10.28776892
139CSNK1G30.27430111
140MAPKAPK20.26745842
141IKBKE0.25764845
142PRKCA0.25319899
143MAP4K10.24842324
144GRK10.24265319
145PRKACG0.22584919
146DYRK1B0.21908139
147PBK0.21791971
148CSNK1A10.20949725
149TNIK0.20797950
150JAK20.20223523
151LYN0.19879355
152SIK30.18693498
153PRKCD0.18059579
154ICK0.17891516
155IRAK30.15587882
156BMPR20.15181668

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.39892065
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.79446624
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.45106885
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.29919892
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.98568575
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.62762909
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.45742675
8Caffeine metabolism_Homo sapiens_hsa002322.44929576
9Fat digestion and absorption_Homo sapiens_hsa049752.27808365
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06688861
11VEGF signaling pathway_Homo sapiens_hsa043702.04364827
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95481129
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.92426439
14Linoleic acid metabolism_Homo sapiens_hsa005911.87829056
15N-Glycan biosynthesis_Homo sapiens_hsa005101.87430377
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86394124
17Renal cell carcinoma_Homo sapiens_hsa052111.84042452
18Complement and coagulation cascades_Homo sapiens_hsa046101.82729030
19Retinol metabolism_Homo sapiens_hsa008301.82523836
20Ovarian steroidogenesis_Homo sapiens_hsa049131.78283494
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77914221
22Pancreatic secretion_Homo sapiens_hsa049721.66975585
23Fatty acid degradation_Homo sapiens_hsa000711.65665826
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60345026
25Fructose and mannose metabolism_Homo sapiens_hsa000511.58716864
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58018008
27Chemical carcinogenesis_Homo sapiens_hsa052041.55030004
28PPAR signaling pathway_Homo sapiens_hsa033201.54247273
29Focal adhesion_Homo sapiens_hsa045101.51991021
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51827158
31Choline metabolism in cancer_Homo sapiens_hsa052311.47366278
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.44752934
33Ras signaling pathway_Homo sapiens_hsa040141.41569351
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40660822
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.39419252
36Platelet activation_Homo sapiens_hsa046111.39345554
37Pancreatic cancer_Homo sapiens_hsa052121.39238867
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36976021
39Tight junction_Homo sapiens_hsa045301.36729602
40ECM-receptor interaction_Homo sapiens_hsa045121.36069981
41Thyroid cancer_Homo sapiens_hsa052161.35822040
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35391300
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.34970246
44Hippo signaling pathway_Homo sapiens_hsa043901.33609512
45Rap1 signaling pathway_Homo sapiens_hsa040151.31344161
46Other glycan degradation_Homo sapiens_hsa005111.31317298
47Renin-angiotensin system_Homo sapiens_hsa046141.27768769
48Amoebiasis_Homo sapiens_hsa051461.26986126
49Endocytosis_Homo sapiens_hsa041441.26795691
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.26090742
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25285915
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.24616892
53Phenylalanine metabolism_Homo sapiens_hsa003601.21618023
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.21574391
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.21289361
56Asthma_Homo sapiens_hsa053101.19691018
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18407382
58Staphylococcus aureus infection_Homo sapiens_hsa051501.18233058
59Histidine metabolism_Homo sapiens_hsa003401.14270151
60Bile secretion_Homo sapiens_hsa049761.11910847
61Proteoglycans in cancer_Homo sapiens_hsa052051.09403571
62Protein digestion and absorption_Homo sapiens_hsa049741.07486231
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06597174
64Ether lipid metabolism_Homo sapiens_hsa005651.02743361
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02276466
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02172869
67Lysosome_Homo sapiens_hsa041421.02160137
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01965073
69Small cell lung cancer_Homo sapiens_hsa052220.99509321
70Arginine and proline metabolism_Homo sapiens_hsa003300.99183103
71Adherens junction_Homo sapiens_hsa045200.98684480
72Long-term depression_Homo sapiens_hsa047300.97856153
73Dorso-ventral axis formation_Homo sapiens_hsa043200.97472759
74Nitrogen metabolism_Homo sapiens_hsa009100.96445127
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95657215
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94389265
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.94197345
78AMPK signaling pathway_Homo sapiens_hsa041520.93955539
79Dilated cardiomyopathy_Homo sapiens_hsa054140.93570824
80Insulin resistance_Homo sapiens_hsa049310.93177766
81Allograft rejection_Homo sapiens_hsa053300.93059216
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92104448
83Autoimmune thyroid disease_Homo sapiens_hsa053200.88181258
84Graft-versus-host disease_Homo sapiens_hsa053320.83710344
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83290164
86Axon guidance_Homo sapiens_hsa043600.82742981
87Tyrosine metabolism_Homo sapiens_hsa003500.81151098
88HIF-1 signaling pathway_Homo sapiens_hsa040660.81063599
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79945000
90Arginine biosynthesis_Homo sapiens_hsa002200.79630591
91Tryptophan metabolism_Homo sapiens_hsa003800.79620638
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79109794
93Estrogen signaling pathway_Homo sapiens_hsa049150.78040151
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77255181
95Arachidonic acid metabolism_Homo sapiens_hsa005900.76751303
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75838682
97GnRH signaling pathway_Homo sapiens_hsa049120.75678406
98Hepatitis C_Homo sapiens_hsa051600.75672989
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74673225
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73496523
101Glioma_Homo sapiens_hsa052140.73125761
102Osteoclast differentiation_Homo sapiens_hsa043800.72987900
103Type I diabetes mellitus_Homo sapiens_hsa049400.70129383
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67777555
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67758202
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.65899606
107Gap junction_Homo sapiens_hsa045400.65439381
108Mineral absorption_Homo sapiens_hsa049780.63970788
109Pertussis_Homo sapiens_hsa051330.63437339
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.62829136
111Vibrio cholerae infection_Homo sapiens_hsa051100.62456824
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62309224
113Phagosome_Homo sapiens_hsa041450.62202718
114Glutathione metabolism_Homo sapiens_hsa004800.62007539
115Non-small cell lung cancer_Homo sapiens_hsa052230.61959317
116Glutamatergic synapse_Homo sapiens_hsa047240.61239857
117Thyroid hormone synthesis_Homo sapiens_hsa049180.61068945
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60770776
119Cocaine addiction_Homo sapiens_hsa050300.60156188
120Endometrial cancer_Homo sapiens_hsa052130.60024718
121Vitamin digestion and absorption_Homo sapiens_hsa049770.59304270
122Leishmaniasis_Homo sapiens_hsa051400.59074298
123Glycerolipid metabolism_Homo sapiens_hsa005610.58926767
124FoxO signaling pathway_Homo sapiens_hsa040680.57426002
125Chronic myeloid leukemia_Homo sapiens_hsa052200.55975884
126Prostate cancer_Homo sapiens_hsa052150.55744676
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55138804
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54321422
129Toxoplasmosis_Homo sapiens_hsa051450.53993298
130Cholinergic synapse_Homo sapiens_hsa047250.53806793
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53723818
132GABAergic synapse_Homo sapiens_hsa047270.53500814
133Pathways in cancer_Homo sapiens_hsa052000.53426394
134Antigen processing and presentation_Homo sapiens_hsa046120.53304779
135Renin secretion_Homo sapiens_hsa049240.52928329
136Inositol phosphate metabolism_Homo sapiens_hsa005620.52185067
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.52030742
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50040234
139Galactose metabolism_Homo sapiens_hsa000520.49706045
140Sphingolipid metabolism_Homo sapiens_hsa006000.49564404
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49408995
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46764202
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46371018
144Melanogenesis_Homo sapiens_hsa049160.45535559
145MAPK signaling pathway_Homo sapiens_hsa040100.45450396
146Hematopoietic cell lineage_Homo sapiens_hsa046400.44575844
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44553687
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44145543
149mTOR signaling pathway_Homo sapiens_hsa041500.42679233
150Sulfur relay system_Homo sapiens_hsa041220.40222907
151Peroxisome_Homo sapiens_hsa041460.38639278
152Salmonella infection_Homo sapiens_hsa051320.37447471
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.36339513
154Influenza A_Homo sapiens_hsa051640.34898700
155Fatty acid metabolism_Homo sapiens_hsa012120.33967031
156Viral myocarditis_Homo sapiens_hsa054160.30895662
157African trypanosomiasis_Homo sapiens_hsa051430.24641044
158TNF signaling pathway_Homo sapiens_hsa046680.22026259
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20807413
160Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20495702
161Tuberculosis_Homo sapiens_hsa051520.20483621
162Fatty acid biosynthesis_Homo sapiens_hsa000610.19736433
163Butanoate metabolism_Homo sapiens_hsa006500.19652236
164Salivary secretion_Homo sapiens_hsa049700.16128852

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