CEACAM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)8.04103885
2diterpenoid biosynthetic process (GO:0016102)6.46695317
3chemical homeostasis within a tissue (GO:0048875)6.19160733
4intestinal epithelial cell development (GO:0060576)6.08515648
5O-glycan processing (GO:0016266)5.66779195
6axonemal dynein complex assembly (GO:0070286)5.51171669
7primary alcohol catabolic process (GO:0034310)5.50697917
8desmosome organization (GO:0002934)4.88447476
9negative regulation of humoral immune response (GO:0002921)4.71468838
10calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.69318028
11doxorubicin metabolic process (GO:0044598)4.58293416
12daunorubicin metabolic process (GO:0044597)4.58293416
13polyketide metabolic process (GO:0030638)4.58293416
14negative regulation of complement activation (GO:0045916)4.44982368
15terpenoid biosynthetic process (GO:0016114)4.44287200
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.38701230
17aminoglycoside antibiotic metabolic process (GO:0030647)4.06657582
18ethanol metabolic process (GO:0006067)4.03135939
19cilium or flagellum-dependent cell motility (GO:0001539)4.02333092
20negative regulation of protein activation cascade (GO:2000258)4.01610843
21oligosaccharide biosynthetic process (GO:0009312)3.99892727
22renal filtration (GO:0097205)3.98204288
23protein autoprocessing (GO:0016540)3.97111257
24pyrimidine-containing compound transmembrane transport (GO:0072531)3.89676273
25complement activation, classical pathway (GO:0006958)3.82643267
26ethanol oxidation (GO:0006069)3.82028764
27Golgi transport vesicle coating (GO:0048200)3.76368441
28COPI coating of Golgi vesicle (GO:0048205)3.76368441
29progesterone metabolic process (GO:0042448)3.76145945
30retinal metabolic process (GO:0042574)3.70673438
31lung secretory cell differentiation (GO:0061140)3.69533917
32motile cilium assembly (GO:0044458)3.66834547
33glomerular filtration (GO:0003094)3.65915769
34retinol metabolic process (GO:0042572)3.64962634
35multicellular organismal water homeostasis (GO:0050891)3.59484406
36primary alcohol metabolic process (GO:0034308)3.55877458
37protein O-linked glycosylation (GO:0006493)3.55095235
38one-carbon compound transport (GO:0019755)3.42731049
39iron ion import (GO:0097286)3.36911800
40intestinal absorption (GO:0050892)3.35624250
41retinoic acid metabolic process (GO:0042573)3.35438085
42regulation of metalloenzyme activity (GO:0048552)3.33005370
43vitamin transmembrane transport (GO:0035461)3.31128280
44negative regulation of myotube differentiation (GO:0010832)3.30565213
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.29133981
46cilium movement (GO:0003341)3.26600924
47complement activation (GO:0006956)3.21313781
48maintenance of gastrointestinal epithelium (GO:0030277)3.17055527
49sperm capacitation (GO:0048240)3.13990019
50sphingomyelin metabolic process (GO:0006684)3.12733236
51positive regulation of respiratory burst (GO:0060267)3.11825708
52negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.05326280
53hypotonic response (GO:0006971)3.02288749
54renal absorption (GO:0070293)3.01061257
55water homeostasis (GO:0030104)2.99516660
56epithelial cell-cell adhesion (GO:0090136)2.99301059
57positive regulation of Cdc42 GTPase activity (GO:0043089)2.95831925
58positive regulation of pseudopodium assembly (GO:0031274)2.92597176
59positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.91460805
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.90644894
61flavonoid metabolic process (GO:0009812)2.89588802
62protein localization to endosome (GO:0036010)2.87790962
63antimicrobial humoral response (GO:0019730)2.87398915
64hemidesmosome assembly (GO:0031581)2.86977655
65antibacterial humoral response (GO:0019731)2.86890252
66cellular glucuronidation (GO:0052695)2.85009522
67regulation of complement activation (GO:0030449)2.84889516
68membrane budding (GO:0006900)2.84841769
69regulation of cholesterol homeostasis (GO:2000188)2.81039582
70cell adhesion mediated by integrin (GO:0033627)2.76417958
71bile acid and bile salt transport (GO:0015721)2.75197611
72regulation of viral release from host cell (GO:1902186)2.74974914
73glycoside metabolic process (GO:0016137)2.74385916
74lung epithelium development (GO:0060428)2.73572760
75regulation of respiratory burst (GO:0060263)2.72935974
76regulation of transforming growth factor beta1 production (GO:0032908)2.71731238
77tight junction assembly (GO:0070830)2.71354482
78sodium ion homeostasis (GO:0055078)2.70354034
79columnar/cuboidal epithelial cell development (GO:0002066)2.69745510
80glucuronate metabolic process (GO:0019585)2.69254885
81uronic acid metabolic process (GO:0006063)2.69254885
82cellular response to vitamin D (GO:0071305)2.69111252
83peptide catabolic process (GO:0043171)2.68532952
84C21-steroid hormone metabolic process (GO:0008207)2.67619857
85skin morphogenesis (GO:0043589)2.67446679
86prostanoid metabolic process (GO:0006692)2.63554895
87prostaglandin metabolic process (GO:0006693)2.63554895
88regulation of protein activation cascade (GO:2000257)2.63537053
89branching involved in mammary gland duct morphogenesis (GO:0060444)2.59856093
90membrane protein proteolysis (GO:0033619)2.59631491
91epithelial cilium movement (GO:0003351)2.58614596
92regulation of interleukin-5 production (GO:0032674)2.58109616
93regulation of pseudopodium assembly (GO:0031272)2.55493015
94positive regulation of vesicle fusion (GO:0031340)2.54805242
95keratinocyte proliferation (GO:0043616)2.54202316
96negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.52923258
97negative regulation of anoikis (GO:2000811)2.51118407
98angiotensin maturation (GO:0002003)2.50698393
99amyloid precursor protein catabolic process (GO:0042987)2.49209333
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47296004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.38611152
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.60883659
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.94256873
4* CDX2_20551321_ChIP-Seq_CACO-2_Human3.81479504
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.60912980
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.50219756
7SOX2_27498859_Chip-Seq_STOMACH_Mouse3.20438351
8* SOX2_20726797_ChIP-Seq_SW620_Human3.14345109
9ESR2_21235772_ChIP-Seq_MCF-7_Human3.08383252
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.04502866
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.66290130
12* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.59251981
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56204853
14GATA4_25053715_ChIP-Seq_YYC3_Human2.46170207
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.38632824
16GATA6_25053715_ChIP-Seq_YYC3_Human2.35915949
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.32330659
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.25669111
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.21767529
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06521445
21KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.06006140
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.04240915
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.00511983
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.00511983
25* RUNX1_27514584_Chip-Seq_MCF-7_Human1.95071189
26FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.88297751
27ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.84411727
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82383391
29* KLF5_25053715_ChIP-Seq_YYC3_Human1.77789995
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.73766859
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.71684588
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.70843080
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68544055
34ZNF263_19887448_ChIP-Seq_K562_Human1.65573061
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64876217
36* AHR_22903824_ChIP-Seq_MCF-7_Human1.63366063
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.59228611
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.58421560
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.58118574
40CLOCK_20551151_ChIP-Seq_293T_Human1.57705780
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57507738
42* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57127864
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.53544324
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.51768098
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.50514622
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49619758
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48236878
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46655431
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38965184
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38593351
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38332838
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38017501
53CJUN_26792858_Chip-Seq_BT549_Human1.37870684
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37188444
55* ARNT_22903824_ChIP-Seq_MCF-7_Human1.29105332
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26509403
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25613621
58TP63_23658742_ChIP-Seq_EP156T_Human1.25422949
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.24773911
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.24664681
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18446187
62FOXA1_25552417_ChIP-Seq_VCAP_Human1.16470019
63AR_21909140_ChIP-Seq_LNCAP_Human1.15571844
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15027974
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13714167
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13586255
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12752507
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11265479
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.09991228
70ATF3_27146783_Chip-Seq_COLON_Human1.07755316
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06764164
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06763031
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04065950
74ELF5_23300383_ChIP-Seq_T47D_Human1.03423212
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02791742
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97535167
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94906696
78GATA2_19941826_ChIP-Seq_K562_Human0.94846223
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92429416
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.92280290
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92078624
82TBX20_22080862_ChIP-Seq_HEART_Mouse0.88794938
83TBX20_22328084_ChIP-Seq_HEART_Mouse0.88794938
84GATA1_19941826_ChIP-Seq_K562_Human0.88695186
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84815329
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84209300
87LXR_22292898_ChIP-Seq_THP-1_Human0.83009882
88CDX2_22108803_ChIP-Seq_LS180_Human0.82883514
89TP63_22573176_ChIP-Seq_HFKS_Human0.82041109
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81555189
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80350228
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79084217
93TP53_18474530_ChIP-ChIP_U2OS_Human0.78160337
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77079969
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76129477
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75763950
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75725171
98CEBPB_22108803_ChIP-Seq_LS180_Human0.74935474
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74456286
100DROSHA_22980978_ChIP-Seq_HELA_Human0.74412035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.78037515
2MP0004782_abnormal_surfactant_physiolog4.92352194
3MP0008875_abnormal_xenobiotic_pharmacok3.52285447
4MP0004264_abnormal_extraembryonic_tissu3.11680439
5MP0010352_gastrointestinal_tract_polyps3.03377230
6MP0005083_abnormal_biliary_tract2.96433345
7MP0002277_abnormal_respiratory_mucosa2.74498210
8MP0001873_stomach_inflammation2.68458939
9MP0010678_abnormal_skin_adnexa2.48232506
10MP0010155_abnormal_intestine_physiology2.46055949
11MP0002796_impaired_skin_barrier2.17376137
12MP0000465_gastrointestinal_hemorrhage2.16099179
13MP0002132_abnormal_respiratory_system2.08228849
14MP0008004_abnormal_stomach_pH2.07452455
15MP0003300_gastrointestinal_ulcer2.03797746
16MP0005165_increased_susceptibility_to1.98036214
17MP0004043_abnormal_pH_regulation1.97236209
18MP0003191_abnormal_cellular_cholesterol1.93669514
19MP0003453_abnormal_keratinocyte_physiol1.90452435
20MP0001664_abnormal_digestion1.87852577
21MP0003866_abnormal_defecation1.84771783
22MP0005085_abnormal_gallbladder_physiolo1.79185995
23MP0002139_abnormal_hepatobiliary_system1.78506272
24MP0005023_abnormal_wound_healing1.76102873
25MP0004947_skin_inflammation1.68624778
26MP0003566_abnormal_cell_adhesion1.67559168
27MP0000477_abnormal_intestine_morphology1.61397901
28MP0005365_abnormal_bile_salt1.61317661
29MP0005166_decreased_susceptibility_to1.59020949
30MP0001666_abnormal_nutrient_absorption1.58190000
31MP0000490_abnormal_crypts_of1.56530667
32MP0001663_abnormal_digestive_system1.53011835
33MP0001765_abnormal_ion_homeostasis1.50530211
34MP0002098_abnormal_vibrissa_morphology1.49842224
35MP0003724_increased_susceptibility_to1.48781976
36MP0004019_abnormal_vitamin_homeostasis1.41410161
37MP0009780_abnormal_chondrocyte_physiolo1.39030550
38MP0000383_abnormal_hair_follicle1.38531300
39MP0001216_abnormal_epidermal_layer1.37751011
40MP0002876_abnormal_thyroid_physiology1.35374942
41MP0005164_abnormal_response_to1.34831190
42MP0005501_abnormal_skin_physiology1.34286073
43MP0003656_abnormal_erythrocyte_physiolo1.33193510
44MP0001849_ear_inflammation1.33186918
45MP0003075_altered_response_to1.20177710
46MP0005381_digestive/alimentary_phenotyp1.19603242
47MP0009643_abnormal_urine_homeostasis1.15537676
48MP0000566_synostosis1.14129314
49MP0000858_altered_metastatic_potential1.13845754
50MP0003806_abnormal_nucleotide_metabolis1.12452382
51MP0003436_decreased_susceptibility_to1.11701599
52MP0002138_abnormal_hepatobiliary_system1.11245226
53MP0002136_abnormal_kidney_physiology1.07479239
54MP0005388_respiratory_system_phenotype1.06504557
55MP0002133_abnormal_respiratory_system1.06504557
56MP0009785_altered_susceptibility_to1.06275601
57MP0002166_altered_tumor_susceptibility1.05198301
58MP0000678_abnormal_parathyroid_gland1.04274232
59MP0010386_abnormal_urinary_bladder1.03534290
60MP0002896_abnormal_bone_mineralization1.01330877
61MP0002060_abnormal_skin_morphology1.01282542
62MP0000537_abnormal_urethra_morphology1.00647151
63MP0000627_abnormal_mammary_gland0.96093133
64MP0005025_abnormal_response_to0.95949266
65MP0002148_abnormal_hypersensitivity_rea0.95840866
66MP0000467_abnormal_esophagus_morphology0.94643087
67MP0001756_abnormal_urination0.92920867
68MP0004147_increased_porphyrin_level0.91807054
69MP0005076_abnormal_cell_differentiation0.91772212
70MP0003091_abnormal_cell_migration0.91718226
71MP0006054_spinal_hemorrhage0.90787988
72MP0005636_abnormal_mineral_homeostasis0.89901641
73MP0003252_abnormal_bile_duct0.89890950
74MP0000377_abnormal_hair_follicle0.89768058
75MP0001845_abnormal_inflammatory_respons0.89089136
76MP0008872_abnormal_physiological_respon0.88486628
77MP0002168_other_aberrant_phenotype0.88032475
78MP0005058_abnormal_lysosome_morphology0.87918991
79MP0003045_fibrosis0.87436026
80MP0000613_abnormal_salivary_gland0.84730583
81MP0002006_tumorigenesis0.84209543
82MP0000470_abnormal_stomach_morphology0.83571885
83MP0005387_immune_system_phenotype0.83294635
84MP0001790_abnormal_immune_system0.83294635
85MP0000681_abnormal_thyroid_gland0.82829876
86MP0001958_emphysema0.80850122
87MP0000462_abnormal_digestive_system0.79096293
88MP0001533_abnormal_skeleton_physiology0.77123345
89MP0002877_abnormal_melanocyte_morpholog0.76001943
90MP0005248_abnormal_Harderian_gland0.75946258
91MP0010771_integument_phenotype0.74021993
92MP0005275_abnormal_skin_tensile0.71509703
93MP0003868_abnormal_feces_composition0.69968100
94MP0001851_eye_inflammation0.69603551
95MP0000249_abnormal_blood_vessel0.69395696
96MP0005310_abnormal_salivary_gland0.68406704
97MP0005670_abnormal_white_adipose0.68058108
98MP0001881_abnormal_mammary_gland0.65631707
99MP0003303_peritoneal_inflammation0.65290835
100MP0003828_pulmonary_edema0.63492421

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.10827624
2Chronic bronchitis (HP:0004469)6.05394591
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.99298538
4Interstitial pulmonary disease (HP:0006530)5.35849965
5Abnormal respiratory motile cilium physiology (HP:0012261)4.99589929
6Rhinitis (HP:0012384)4.93354686
7Abnormal respiratory motile cilium morphology (HP:0005938)4.84390201
8Abnormal respiratory epithelium morphology (HP:0012253)4.84390201
9Abnormal ciliary motility (HP:0012262)4.69341317
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.56788670
11Absent/shortened dynein arms (HP:0200106)4.56788670
12Right ventricular cardiomyopathy (HP:0011663)4.55937210
13Bronchiectasis (HP:0002110)4.48529688
14Abnormality of chloride homeostasis (HP:0011422)4.46760599
15Conjugated hyperbilirubinemia (HP:0002908)4.30487049
16Nasal polyposis (HP:0100582)4.19866614
17Decreased circulating renin level (HP:0003351)3.92396836
18Abnormality of the nasal mucosa (HP:0000433)3.90513628
19Abnormality of renin-angiotensin system (HP:0000847)3.74561723
20Hyperaldosteronism (HP:0000859)3.54476896
21Renal salt wasting (HP:0000127)3.52215730
22Hyperkalemia (HP:0002153)3.36365389
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.30755902
24Bronchitis (HP:0012387)3.30439312
25Glomerulosclerosis (HP:0000096)3.29324906
26Male infertility (HP:0003251)3.28824227
27Flat acetabular roof (HP:0003180)3.26748538
28Focal segmental glomerulosclerosis (HP:0000097)3.25470691
29Tubulointerstitial fibrosis (HP:0005576)3.24090557
30Ileus (HP:0002595)3.07827511
31Hyponatremia (HP:0002902)2.84920056
32Tubular atrophy (HP:0000092)2.77962752
33Alopecia of scalp (HP:0002293)2.64128118
34Systemic lupus erythematosus (HP:0002725)2.58593906
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.58275198
36Osteolytic defects of the hand bones (HP:0009699)2.58275198
37Hypotension (HP:0002615)2.51838063
38Vascular calcification (HP:0004934)2.50868280
39Villous atrophy (HP:0011473)2.50015999
40Abnormality of small intestinal villus morphology (HP:0011472)2.50015999
41Tubulointerstitial nephritis (HP:0001970)2.44009641
42Arterial tortuosity (HP:0005116)2.43238099
43Abnormality of sodium homeostasis (HP:0010931)2.36228888
44Malnutrition (HP:0004395)2.35972489
45Recurrent otitis media (HP:0000403)2.27399580
46Abnormality of the distal phalanges of the toes (HP:0010182)2.25630018
47Abnormality of the gastric mucosa (HP:0004295)2.24358582
48Cone-rod dystrophy (HP:0000548)2.20914264
49Recurrent sinusitis (HP:0011108)2.20503892
50Pili torti (HP:0003777)2.20105631
51Infertility (HP:0000789)2.18140148
52Hyperuricemia (HP:0002149)2.18001214
53Increased purine levels (HP:0004368)2.18001214
54Complement deficiency (HP:0004431)2.17322488
55Gout (HP:0001997)2.16126187
56Abnormality of complement system (HP:0005339)2.15454085
57Chronic sinusitis (HP:0011109)2.15269090
58Cardiovascular calcification (HP:0011915)2.14902047
59Flattened epiphyses (HP:0003071)2.14492822
60Dehydration (HP:0001944)2.12302029
61Glomerulonephritis (HP:0000099)2.10097161
62Alkalosis (HP:0001948)2.08842660
63Tubulointerstitial abnormality (HP:0001969)2.08472886
64Hemorrhage of the eye (HP:0011885)2.07407204
65Vascular tortuosity (HP:0004948)2.05739918
66Abnormal tarsal ossification (HP:0008369)2.00848995
67Intrahepatic cholestasis (HP:0001406)1.99850865
68Eczematoid dermatitis (HP:0000976)1.97802894
69Periodontitis (HP:0000704)1.97304050
70Hypoplasia of dental enamel (HP:0006297)1.95572661
71Nephritis (HP:0000123)1.95398824
72Widely patent fontanelles and sutures (HP:0004492)1.94868797
73Fat malabsorption (HP:0002630)1.94449883
74Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90217267
75Plantar hyperkeratosis (HP:0007556)1.89671779
76Abnormal hair laboratory examination (HP:0003328)1.88841996
77Adrenal overactivity (HP:0002717)1.87104775
78Metabolic alkalosis (HP:0200114)1.85661444
79Growth hormone excess (HP:0000845)1.81652285
80Rectal prolapse (HP:0002035)1.81163746
81Curly hair (HP:0002212)1.81090325
82Abnormal biliary tract morphology (HP:0012440)1.80674983
83Premature loss of primary teeth (HP:0006323)1.80196303
84Vertebral hypoplasia (HP:0008417)1.79782390
85Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79782390
86Exocrine pancreatic insufficiency (HP:0001738)1.77726581
87Chronic otitis media (HP:0000389)1.77348056
88Fragile skin (HP:0001030)1.76344007
89Abnormal pancreas size (HP:0012094)1.76342388
90Spinal cord compression (HP:0002176)1.74080148
91Mucopolysacchariduria (HP:0008155)1.73557917
92Urinary glycosaminoglycan excretion (HP:0003541)1.73557917
93Broad face (HP:0000283)1.71708092
94Severe short stature (HP:0003510)1.68652863
95Facial shape deformation (HP:0011334)1.65501584
96Potter facies (HP:0002009)1.65501584
97Abnormality of potassium homeostasis (HP:0011042)1.64809750
98Pustule (HP:0200039)1.61878751
99Distal lower limb muscle weakness (HP:0009053)1.60918489
100Atrophic scars (HP:0001075)1.60312535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.32897337
2EPHA27.76880368
3LMTK25.71942916
4MET3.77650366
5MST43.31581630
6ERN12.62861842
7STK391.99798859
8RIPK11.82572960
9PIK3CA1.72842215
10EPHB21.71010024
11MAPK151.56893794
12MAP3K121.56233189
13STK241.51568658
14FER1.42809399
15EPHB11.39294074
16PRKG21.38415608
17PAK41.36465367
18MAP3K21.23323921
19PTK21.14882875
20MAPKAPK31.13201985
21BCR1.11557000
22OXSR11.10274083
23MAP3K31.09459740
24TESK11.04437323
25EPHA31.04074210
26LRRK20.95635443
27EIF2AK30.94622595
28TRPM70.93028721
29FGFR40.91706190
30PTK60.85219569
31PRKCI0.82521436
32STK100.82330780
33IRAK30.81649257
34ERBB30.79711194
35SIK30.78827543
36BMX0.71522525
37ZAP700.70010889
38TRIB30.68084945
39MATK0.66768451
40STK38L0.65236889
41EIF2AK10.63647127
42CDC42BPA0.60402199
43ERBB40.57576750
44MYLK0.57045089
45PDGFRB0.56497735
46YES10.52133093
47LATS10.51492628
48FGFR30.51279641
49ERBB20.49963352
50SIK10.49825706
51NEK60.49429522
52MAP3K140.48736775
53IRAK10.45478860
54TYK20.43732582
55BMPR20.43464542
56JAK10.43456304
57MAP3K130.43092979
58NEK90.42359652
59TGFBR20.41943229
60ACVR1B0.41318893
61BRSK20.41204261
62SMG10.40183638
63MAP3K10.39869560
64TBK10.39316345
65NME10.39006624
66PHKG20.37474748
67PHKG10.37474748
68TAOK10.37153394
69PDGFRA0.36731370
70NME20.36408353
71STK380.35593800
72CSK0.35275188
73IGF1R0.33524779
74EEF2K0.32357380
75RPS6KB20.32120459
76PRKAA20.31820324
77PRKCD0.31636470
78MAP3K70.31056349
79DMPK0.31035814
80PDPK10.29857705
81STK30.29782800
82CHUK0.28217569
83CSF1R0.27929082
84MAP2K60.27673538
85HIPK20.27585315
86SRC0.26695306
87MAP4K20.25857104
88ROCK10.24404798
89MAPKAPK20.23919857
90MAPK110.23521934
91SCYL20.22261074
92CDK60.21914701
93EGFR0.20337487
94DDR20.19399917
95MAP2K10.18623364
96PRKCQ0.18360915
97ABL20.18329639
98MELK0.17389254
99NTRK10.13618812
100LIMK10.13199444

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.73065637
2Histidine metabolism_Homo sapiens_hsa003403.23320039
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.18714180
4Sulfur metabolism_Homo sapiens_hsa009202.84614048
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59772134
6Phenylalanine metabolism_Homo sapiens_hsa003602.38743897
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.36847853
8Caffeine metabolism_Homo sapiens_hsa002322.21053760
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08272934
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05325635
11Chemical carcinogenesis_Homo sapiens_hsa052042.04776713
12Retinol metabolism_Homo sapiens_hsa008301.97161966
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90529745
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89477373
15Mineral absorption_Homo sapiens_hsa049781.86706037
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74947843
17Tyrosine metabolism_Homo sapiens_hsa003501.60034587
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56528481
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.56408941
20Fructose and mannose metabolism_Homo sapiens_hsa000511.56243741
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.53601364
22Staphylococcus aureus infection_Homo sapiens_hsa051501.52006691
23Glutathione metabolism_Homo sapiens_hsa004801.46773652
24Starch and sucrose metabolism_Homo sapiens_hsa005001.46009222
25Asthma_Homo sapiens_hsa053101.44379611
26Sphingolipid metabolism_Homo sapiens_hsa006001.42350054
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.39421917
28Bile secretion_Homo sapiens_hsa049761.36666047
29Tight junction_Homo sapiens_hsa045301.32534845
30Complement and coagulation cascades_Homo sapiens_hsa046101.30637140
31beta-Alanine metabolism_Homo sapiens_hsa004101.25610137
32Other glycan degradation_Homo sapiens_hsa005111.24221977
33Galactose metabolism_Homo sapiens_hsa000521.19699077
34Arginine biosynthesis_Homo sapiens_hsa002201.19265679
35Nitrogen metabolism_Homo sapiens_hsa009101.16957975
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.15366858
37Lysosome_Homo sapiens_hsa041421.15293549
38Pancreatic secretion_Homo sapiens_hsa049721.15226274
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08707941
40Arachidonic acid metabolism_Homo sapiens_hsa005901.07217460
41Allograft rejection_Homo sapiens_hsa053301.06439456
42Adherens junction_Homo sapiens_hsa045201.06279000
43Hepatitis C_Homo sapiens_hsa051601.03676462
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01739446
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.01527128
46Autoimmune thyroid disease_Homo sapiens_hsa053201.00824788
47Fatty acid degradation_Homo sapiens_hsa000711.00765269
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96893236
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.94476753
50Graft-versus-host disease_Homo sapiens_hsa053320.92441109
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88204005
52Renin-angiotensin system_Homo sapiens_hsa046140.87957993
53Pertussis_Homo sapiens_hsa051330.84963498
54ABC transporters_Homo sapiens_hsa020100.84687509
55Antigen processing and presentation_Homo sapiens_hsa046120.84406453
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84371365
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81587828
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78904521
59Type I diabetes mellitus_Homo sapiens_hsa049400.78151931
60Thyroid hormone synthesis_Homo sapiens_hsa049180.77552750
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75745149
62Vibrio cholerae infection_Homo sapiens_hsa051100.72886183
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71710280
64Arginine and proline metabolism_Homo sapiens_hsa003300.70368287
65ECM-receptor interaction_Homo sapiens_hsa045120.69706170
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68987711
67Glycerolipid metabolism_Homo sapiens_hsa005610.68902298
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67356060
69Influenza A_Homo sapiens_hsa051640.66190591
70Fat digestion and absorption_Homo sapiens_hsa049750.64668513
71Leishmaniasis_Homo sapiens_hsa051400.62779250
72Viral myocarditis_Homo sapiens_hsa054160.60969666
73Toxoplasmosis_Homo sapiens_hsa051450.60543633
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55215657
75Linoleic acid metabolism_Homo sapiens_hsa005910.53833342
76PPAR signaling pathway_Homo sapiens_hsa033200.53585670
77Amoebiasis_Homo sapiens_hsa051460.52398688
78Phagosome_Homo sapiens_hsa041450.52343585
79Salivary secretion_Homo sapiens_hsa049700.46878853
80N-Glycan biosynthesis_Homo sapiens_hsa005100.45142735
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44136642
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42661287
83Tryptophan metabolism_Homo sapiens_hsa003800.42602003
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.42447355
85Protein digestion and absorption_Homo sapiens_hsa049740.42232644
86TNF signaling pathway_Homo sapiens_hsa046680.42108137
87Ether lipid metabolism_Homo sapiens_hsa005650.40751708
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.39244290
89Proteoglycans in cancer_Homo sapiens_hsa052050.39136243
90Thyroid cancer_Homo sapiens_hsa052160.38647823
91Fatty acid biosynthesis_Homo sapiens_hsa000610.37885124
92Apoptosis_Homo sapiens_hsa042100.34226009
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33971137
94African trypanosomiasis_Homo sapiens_hsa051430.33437586
95Hematopoietic cell lineage_Homo sapiens_hsa046400.33322793
96Pancreatic cancer_Homo sapiens_hsa052120.32953978
97Circadian rhythm_Homo sapiens_hsa047100.32890718
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32682842
99Tuberculosis_Homo sapiens_hsa051520.31426379
100Endocytosis_Homo sapiens_hsa041440.30347227

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