CEACAMP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of guanylate cyclase activity (GO:0031284)7.19448415
2regulation of guanylate cyclase activity (GO:0031282)6.44139668
3antigen processing and presentation via MHC class Ib (GO:0002475)6.22023378
4sphingoid metabolic process (GO:0046519)6.12150091
5sphingosine metabolic process (GO:0006670)6.06619807
6DNA deamination (GO:0045006)5.85809961
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.80662323
8diol metabolic process (GO:0034311)5.52296731
9cytidine deamination (GO:0009972)5.22479101
10cytidine metabolic process (GO:0046087)5.22479101
11cytidine catabolic process (GO:0006216)5.22479101
12positive regulation of cGMP biosynthetic process (GO:0030828)4.92097470
13pseudouridine synthesis (GO:0001522)4.89216969
14peristalsis (GO:0030432)4.57308677
15regulation of cGMP biosynthetic process (GO:0030826)4.56499890
16negative regulation of organelle assembly (GO:1902116)4.51114354
17amino acid salvage (GO:0043102)4.47869098
18L-methionine salvage (GO:0071267)4.47869098
19L-methionine biosynthetic process (GO:0071265)4.47869098
20regulation of meiosis I (GO:0060631)4.36586734
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.36090245
22positive regulation of cGMP metabolic process (GO:0030825)4.33081975
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.30526088
24DNA methylation involved in gamete generation (GO:0043046)4.27761190
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19533271
26sulfate transport (GO:0008272)4.13673231
27regulation of cGMP metabolic process (GO:0030823)3.97834661
28protein-chromophore linkage (GO:0018298)3.97317739
29lipopolysaccharide biosynthetic process (GO:0009103)3.78285524
30regulation of rhodopsin mediated signaling pathway (GO:0022400)3.74225108
31piRNA metabolic process (GO:0034587)3.69734896
32atrial cardiac muscle cell action potential (GO:0086014)3.69583933
33urinary tract smooth muscle contraction (GO:0014848)3.63963018
34gap junction assembly (GO:0016264)3.63836900
35rhodopsin mediated signaling pathway (GO:0016056)3.63342873
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55266981
37positive regulation of uterine smooth muscle contraction (GO:0070474)3.54953503
38kidney morphogenesis (GO:0060993)3.52167327
39SMAD protein complex assembly (GO:0007183)3.49587742
40regulation of hippo signaling (GO:0035330)3.46876434
41phasic smooth muscle contraction (GO:0014821)3.42114992
42pericardium development (GO:0060039)3.41513755
43postsynaptic membrane organization (GO:0001941)3.41239314
44methionine biosynthetic process (GO:0009086)3.35920758
45tachykinin receptor signaling pathway (GO:0007217)3.35906895
46positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.32850766
47positive regulation of antigen processing and presentation (GO:0002579)3.30195337
48signal peptide processing (GO:0006465)3.24203056
49endosome to pigment granule transport (GO:0043485)3.21129383
50endosome to melanosome transport (GO:0035646)3.21129383
51arginine catabolic process (GO:0006527)3.20843209
52parturition (GO:0007567)3.20570787
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14418096
54regulation of microtubule-based movement (GO:0060632)3.13243822
55positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.12252116
56positive regulation of cyclase activity (GO:0031281)3.11958645
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10031154
58positive regulation of lyase activity (GO:0051349)3.09629091
59regulation of uterine smooth muscle contraction (GO:0070472)3.07039406
60flavonoid metabolic process (GO:0009812)3.00741540
61response to redox state (GO:0051775)2.94171272
62lipopolysaccharide metabolic process (GO:0008653)2.92069853
63response to nitrosative stress (GO:0051409)2.88131420
64adult feeding behavior (GO:0008343)2.88126246
65methionine metabolic process (GO:0006555)2.85189271
66musculoskeletal movement (GO:0050881)2.84512531
67multicellular organismal movement (GO:0050879)2.84512531
68positive regulation of natural killer cell differentiation (GO:0032825)2.81863579
69sulfur compound transport (GO:0072348)2.81248826
70nodal signaling pathway (GO:0038092)2.79058885
71regulation of respiratory system process (GO:0044065)2.75070853
72positive regulation of respiratory burst (GO:0060267)2.74583659
73growth hormone secretion (GO:0030252)2.74067110
74positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.73774865
75negative regulation of systemic arterial blood pressure (GO:0003085)2.73128129
76serotonin receptor signaling pathway (GO:0007210)2.71847432
77proteasome assembly (GO:0043248)2.71107550
78regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.69778747
79sulfation (GO:0051923)2.68554999
80sulfate transmembrane transport (GO:1902358)2.67747985
81regulation of appetite (GO:0032098)2.67186222
82nucleoside salvage (GO:0043174)2.65464951
83diterpenoid biosynthetic process (GO:0016102)2.63912876
84negative regulation of interleukin-1 beta production (GO:0032691)2.63180700
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61676120
86keratinization (GO:0031424)2.59954523
87regulation of cilium movement (GO:0003352)2.59192157
88DNA-dependent DNA replication (GO:0006261)2.56801481
89cornea development in camera-type eye (GO:0061303)2.56510476
90membrane raft organization (GO:0031579)2.55397244
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.53261228
92L-phenylalanine catabolic process (GO:0006559)2.53261228
93mannosylation (GO:0097502)2.51207919
94positive regulation of ERBB signaling pathway (GO:1901186)2.51072527
95regulation of response to food (GO:0032095)2.50787530
96sympathetic nervous system development (GO:0048485)2.50748952
97negative regulation of blood pressure (GO:0045776)2.49641638
98vitamin transmembrane transport (GO:0035461)2.48894495
99antigen processing and presentation of endogenous antigen (GO:0019883)2.44641283
100cellular ketone body metabolic process (GO:0046950)2.44121146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.71999957
2GBX2_23144817_ChIP-Seq_PC3_Human3.11800837
3ZNF274_21170338_ChIP-Seq_K562_Hela3.00973690
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87885727
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46930732
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32748489
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.24723678
8TP53_18474530_ChIP-ChIP_U2OS_Human2.21512309
9P300_19829295_ChIP-Seq_ESCs_Human2.19732831
10VDR_22108803_ChIP-Seq_LS180_Human2.13631049
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09816334
12AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.06608109
13CJUN_26792858_Chip-Seq_BT549_Human2.06082909
14TP53_16413492_ChIP-PET_HCT116_Human2.04039883
15ER_23166858_ChIP-Seq_MCF-7_Human2.02916504
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97361529
17IGF1R_20145208_ChIP-Seq_DFB_Human1.93301500
18STAT3_23295773_ChIP-Seq_U87_Human1.85958667
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.80046083
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75754415
21JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73860744
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71110327
23JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70300325
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68840584
25SMAD4_21799915_ChIP-Seq_A2780_Human1.68740809
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68438976
27TCF4_23295773_ChIP-Seq_U87_Human1.66794444
28AR_21572438_ChIP-Seq_LNCaP_Human1.60305904
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.59265856
30EZH2_22144423_ChIP-Seq_EOC_Human1.59093463
31CBP_20019798_ChIP-Seq_JUKART_Human1.58193949
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58193949
33AR_25329375_ChIP-Seq_VCAP_Human1.57464270
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56913906
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56608232
36FUS_26573619_Chip-Seq_HEK293_Human1.53002432
37EWS_26573619_Chip-Seq_HEK293_Human1.52457981
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.51279152
39TCF4_22108803_ChIP-Seq_LS180_Human1.49294229
40SMAD4_21741376_ChIP-Seq_EPCs_Human1.48084028
41TAF15_26573619_Chip-Seq_HEK293_Human1.47707913
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46855814
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46261623
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45659065
45SOX2_19829295_ChIP-Seq_ESCs_Human1.43200686
46NANOG_19829295_ChIP-Seq_ESCs_Human1.43200686
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.43189056
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42198708
49HOXB7_26014856_ChIP-Seq_BT474_Human1.38330577
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37516246
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36548441
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35610066
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32680235
54TP63_23658742_ChIP-Seq_EP156T_Human1.31654369
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30854190
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.30854190
57CDX2_22108803_ChIP-Seq_LS180_Human1.30762942
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30081408
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28822304
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27553574
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27553574
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26651104
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.25209432
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.25068467
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24775996
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22503043
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19768765
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.18740080
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17493392
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16857666
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.16007107
72TP53_22573176_ChIP-Seq_HFKS_Human1.14795281
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13158776
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12452314
75OCT1_27270436_Chip-Seq_PROSTATE_Human1.11514681
76NCOR_22424771_ChIP-Seq_293T_Human1.10867874
77AHR_22903824_ChIP-Seq_MCF-7_Human1.09072475
78TBL1_22424771_ChIP-Seq_293T_Human1.08067090
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.07592526
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07437544
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.07097195
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06877511
83FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06270646
84FOXH1_21741376_ChIP-Seq_EPCs_Human1.06076455
85BRD4_25478319_ChIP-Seq_HGPS_Human1.05063784
86JUN_21703547_ChIP-Seq_K562_Human1.04351066
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04002457
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03917966
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03852631
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03106509
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01605232
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01396078
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00088874
94PHF8_20622853_ChIP-Seq_HELA_Human0.99872584
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.99646618
96CBP_21632823_ChIP-Seq_H3396_Human0.99121385
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97642978
98NFYB_21822215_ChIP-Seq_K562_Human0.97258525
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96529395
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.96299922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.24090390
2MP0003195_calcinosis5.12743131
3MP0003646_muscle_fatigue5.01181895
4MP0003950_abnormal_plasma_membrane4.45279409
5MP0002837_dystrophic_cardiac_calcinosis4.03255537
6MP0000569_abnormal_digit_pigmentation3.82259400
7MP0001348_abnormal_lacrimal_gland3.34806660
8MP0005171_absent_coat_pigmentation2.96818163
9MP0009697_abnormal_copulation2.76581207
10MP0005167_abnormal_blood-brain_barrier2.57770078
11MP0002102_abnormal_ear_morphology2.52268250
12MP0002735_abnormal_chemical_nociception2.47732927
13MP0003136_yellow_coat_color2.42532963
14MP0010386_abnormal_urinary_bladder2.37082380
15MP0003718_maternal_effect2.24013799
16MP0004043_abnormal_pH_regulation2.15586481
17MP0005085_abnormal_gallbladder_physiolo2.11647659
18MP0006276_abnormal_autonomic_nervous1.99619329
19MP0010678_abnormal_skin_adnexa1.93383316
20MP0003890_abnormal_embryonic-extraembry1.87315150
21MP0003252_abnormal_bile_duct1.85293472
22MP0009840_abnormal_foam_cell1.81301948
23MP0008872_abnormal_physiological_respon1.77608103
24MP0003045_fibrosis1.75730703
25MP0002653_abnormal_ependyma_morphology1.75307726
26MP0003137_abnormal_impulse_conducting1.70146621
27MP0000383_abnormal_hair_follicle1.64861410
28MP0002138_abnormal_hepatobiliary_system1.63197668
29MP0003879_abnormal_hair_cell1.61126837
30MP0005257_abnormal_intraocular_pressure1.58934950
31MP0004233_abnormal_muscle_weight1.57255200
32MP0005551_abnormal_eye_electrophysiolog1.54700122
33MP0004272_abnormal_basement_membrane1.54450084
34MP0001970_abnormal_pain_threshold1.50023220
35MP0005360_urolithiasis1.48497337
36MP0005395_other_phenotype1.45188703
37MP0001501_abnormal_sleep_pattern1.43211575
38MP0002733_abnormal_thermal_nociception1.34184161
39MP0002168_other_aberrant_phenotype1.33978937
40MP0005646_abnormal_pituitary_gland1.26631772
41MP0000427_abnormal_hair_cycle1.22977019
42MP0002139_abnormal_hepatobiliary_system1.21872618
43MP0006054_spinal_hemorrhage1.21531270
44MP0009046_muscle_twitch1.15631027
45MP0000230_abnormal_systemic_arterial1.13402605
46MP0005174_abnormal_tail_pigmentation1.10261847
47MP0005084_abnormal_gallbladder_morpholo1.09535685
48MP0001984_abnormal_olfaction1.07255648
49MP0004084_abnormal_cardiac_muscle1.05909584
50MP0008875_abnormal_xenobiotic_pharmacok1.05050249
51MP0001849_ear_inflammation1.02224933
52MP0000749_muscle_degeneration1.02057360
53MP0001486_abnormal_startle_reflex1.00213216
54MP0006082_CNS_inflammation0.95628085
55MP0003183_abnormal_peptide_metabolism0.95187749
56MP0004381_abnormal_hair_follicle0.88432384
57MP0000647_abnormal_sebaceous_gland0.87296996
58MP0005386_behavior/neurological_phenoty0.86434799
59MP0004924_abnormal_behavior0.86434799
60MP0003880_abnormal_central_pattern0.85533454
61MP0000015_abnormal_ear_pigmentation0.82773728
62MP0002876_abnormal_thyroid_physiology0.82346059
63MP0004085_abnormal_heartbeat0.82192703
64MP0003806_abnormal_nucleotide_metabolis0.81151099
65MP0001529_abnormal_vocalization0.81098152
66MP0005075_abnormal_melanosome_morpholog0.80079126
67MP0005670_abnormal_white_adipose0.79433619
68MP0001905_abnormal_dopamine_level0.78957987
69MP0004782_abnormal_surfactant_physiolog0.78683032
70MP0002095_abnormal_skin_pigmentation0.78137377
71MP0002938_white_spotting0.77073659
72MP0001664_abnormal_digestion0.75671391
73MP0009780_abnormal_chondrocyte_physiolo0.75643061
74MP0002332_abnormal_exercise_endurance0.74154960
75MP0005410_abnormal_fertilization0.73997370
76MP0002736_abnormal_nociception_after0.73622079
77MP0001324_abnormal_eye_pigmentation0.73303037
78MP0005620_abnormal_muscle_contractility0.71431613
79MP0002734_abnormal_mechanical_nocicepti0.68852626
80MP0002160_abnormal_reproductive_system0.67986772
81MP0002254_reproductive_system_inflammat0.67869023
82MP0000534_abnormal_ureter_morphology0.66145990
83MP0005266_abnormal_metabolism0.65563656
84MP0008775_abnormal_heart_ventricle0.64440163
85MP0000538_abnormal_urinary_bladder0.62705292
86MP0002269_muscular_atrophy0.62189118
87MP0005645_abnormal_hypothalamus_physiol0.61335534
88MP0010329_abnormal_lipoprotein_level0.59992032
89MP0004036_abnormal_muscle_relaxation0.58918176
90MP0009250_abnormal_appendicular_skeleto0.56957668
91MP0009745_abnormal_behavioral_response0.56414521
92MP0005365_abnormal_bile_salt0.55605809
93MP0003941_abnormal_skin_development0.55046547
94MP0002272_abnormal_nervous_system0.54212278
95MP0005197_abnormal_uvea_morphology0.54079586
96MP0002972_abnormal_cardiac_muscle0.53652079
97MP0005595_abnormal_vascular_smooth0.51647905
98MP0002928_abnormal_bile_duct0.48197597
99MP0005389_reproductive_system_phenotype0.47375174
100MP0004215_abnormal_myocardial_fiber0.47353063

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)7.06684452
2Microretrognathia (HP:0000308)5.31052191
3Pancreatic cysts (HP:0001737)4.06186130
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.92154829
5Aplasia/Hypoplasia of the sternum (HP:0006714)3.85341859
6Hyperventilation (HP:0002883)3.76894191
7Diastasis recti (HP:0001540)3.71818166
8Amelogenesis imperfecta (HP:0000705)3.61445872
9Parakeratosis (HP:0001036)3.58776427
10Patellar aplasia (HP:0006443)3.56866156
11Aplasia/Hypoplasia of the patella (HP:0006498)3.38314981
12Type II lissencephaly (HP:0007260)3.19311323
13Inability to walk (HP:0002540)3.18867850
14Poor head control (HP:0002421)3.17643103
15Congenital ichthyosiform erythroderma (HP:0007431)3.14634319
16Congenital stationary night blindness (HP:0007642)3.12002239
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.00780872
18Abnormality of glycolipid metabolism (HP:0010969)3.00780872
19Abnormality of liposaccharide metabolism (HP:0010968)3.00780872
20Pancreatic fibrosis (HP:0100732)2.95375191
21Poor speech (HP:0002465)2.94805820
22Abnormality of the renal cortex (HP:0011035)2.91560983
23Chorioretinal atrophy (HP:0000533)2.80235619
24True hermaphroditism (HP:0010459)2.77063994
25Abnormality of proline metabolism (HP:0010907)2.71757919
26Hydroxyprolinuria (HP:0003080)2.71757919
27Nephronophthisis (HP:0000090)2.67531209
28Albinism (HP:0001022)2.66734004
29Slender long bone (HP:0003100)2.64309442
30Recurrent pneumonia (HP:0006532)2.61877784
31Large eyes (HP:0001090)2.61707444
32Abnormality of the renal medulla (HP:0100957)2.52805342
33Acanthocytosis (HP:0001927)2.51520764
34Microtia (HP:0008551)2.51451073
35Lissencephaly (HP:0001339)2.48319449
36Medial flaring of the eyebrow (HP:0010747)2.45393338
37Congenital primary aphakia (HP:0007707)2.40854317
38Progressive inability to walk (HP:0002505)2.38555380
39Hypokinesia (HP:0002375)2.38475328
40Gonadotropin excess (HP:0000837)2.34064537
41Coxa vara (HP:0002812)2.33128038
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32776427
43Gait imbalance (HP:0002141)2.31860937
44Molar tooth sign on MRI (HP:0002419)2.29746054
45Abnormality of midbrain morphology (HP:0002418)2.29746054
46Myokymia (HP:0002411)2.29344086
47Global brain atrophy (HP:0002283)2.26958786
48Opisthotonus (HP:0002179)2.25299177
49Increased density of long bones (HP:0006392)2.22914363
50Tubular atrophy (HP:0000092)2.20491967
51Congenital sensorineural hearing impairment (HP:0008527)2.20351162
52Long foot (HP:0001833)2.20111175
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.19755433
54Nephrogenic diabetes insipidus (HP:0009806)2.17509702
55Type I transferrin isoform profile (HP:0003642)2.15005836
56Furrowed tongue (HP:0000221)2.12714326
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08746793
58Abnormality of the pons (HP:0007361)2.08560772
59Abnormality of the clitoris (HP:0000056)2.08042655
60Female pseudohermaphroditism (HP:0010458)2.07773963
61Depressed nasal tip (HP:0000437)2.04781713
62Genu varum (HP:0002970)2.04774603
63Scrotal hypoplasia (HP:0000046)2.01955058
64Abnormality of macular pigmentation (HP:0008002)2.00984686
65Birth length less than 3rd percentile (HP:0003561)11.3317408
66Breast aplasia (HP:0100783)1.97713109
67Abnormal albumin level (HP:0012116)1.97129634
68Hypoalbuminemia (HP:0003073)1.97129634
69Spondylolisthesis (HP:0003302)1.96338783
70Widely spaced teeth (HP:0000687)1.95393200
71Fair hair (HP:0002286)1.94312943
72Severe visual impairment (HP:0001141)1.90470650
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90034013
74Hypoplasia of the maxilla (HP:0000327)1.88854869
75Cystic liver disease (HP:0006706)1.87337115
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86050635
77Chronic hepatic failure (HP:0100626)1.81867219
78Retinal dysplasia (HP:0007973)1.81746371
79Protruding tongue (HP:0010808)1.80576584
80Palpitations (HP:0001962)1.80048691
81Hypoplasia of the pons (HP:0012110)1.78112230
82Aplasia/Hypoplasia of the breasts (HP:0010311)1.77061814
83Attenuation of retinal blood vessels (HP:0007843)1.76842691
84Vaginal atresia (HP:0000148)1.76341131
85Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75830246
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.73205415
87Genital tract atresia (HP:0001827)1.73166679
88Hypophosphatemic rickets (HP:0004912)1.72852941
89Aplastic anemia (HP:0001915)1.72734085
90Erythroderma (HP:0001019)1.72607496
91Short foot (HP:0001773)1.68993758
92Difficulty walking (HP:0002355)1.68991375
93Poor coordination (HP:0002370)1.68291205
94Pendular nystagmus (HP:0012043)1.67132375
95Absent speech (HP:0001344)1.66320735
96Anterior segment dysgenesis (HP:0007700)1.66274902
97Aplasia/hypoplasia of the uterus (HP:0008684)1.65233431
98Pigmentary retinal degeneration (HP:0001146)1.64863152
99Upper limb muscle weakness (HP:0003484)1.63219120
100Long nose (HP:0003189)1.60813016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.60030580
2BMPR1B4.75463545
3LATS14.47275742
4STK38L4.03194329
5CASK3.66536547
6DAPK23.58755517
7FRK3.51792458
8ZAK3.19944363
9MST42.33655002
10TGFBR12.07362844
11MELK1.99309826
12MAP4K21.96767981
13NEK91.96699637
14LATS21.90765833
15NME11.86098850
16STK381.84182061
17MST1R1.77825576
18BCR1.54855016
19TXK1.53936736
20CAMKK11.48845400
21ADRBK11.46564164
22MET1.41082373
23MYLK1.24061674
24MAPKAPK31.23035039
25GRK71.22388641
26EPHA21.17966560
27MAP3K121.16074914
28WNK41.13224634
29ADRBK21.12744129
30MAP2K11.06422197
31TRIM281.03984138
32PDK20.98762711
33MAP2K60.91342351
34NEK10.86893342
35NEK20.86333094
36PRKAA20.85917098
37CSNK1A1L0.83586615
38BCKDK0.82218169
39PTK2B0.77068041
40KSR20.76581357
41STK160.75279857
42CAMKK20.74685365
43MAP3K70.71429976
44TRPM70.66424901
45MAP3K20.66038572
46EIF2AK30.65807313
47PIK3CG0.60470443
48ABL20.59868327
49MKNK20.59799477
50STK30.59609398
51CAMK2A0.57749417
52PLK20.56819852
53GRK10.55854647
54PKN10.53801910
55PINK10.53459010
56CAMK10.50302289
57FLT30.45685960
58PRKG20.45173906
59PRKCE0.45130313
60PBK0.44196110
61TLK10.43504667
62CSNK1G30.42594512
63KDR0.42064864
64ARAF0.41484628
65BMX0.40010688
66PAK20.36559145
67PLK30.35028465
68CSNK1G20.34954233
69PAK60.34660142
70OXSR10.34600781
71MOS0.33916215
72CAMK1D0.33799584
73DAPK10.33336443
74BRSK20.33163055
75TAOK30.32253436
76MAP2K20.32003925
77PLK10.30898242
78TTK0.30178035
79NLK0.28534295
80ERBB30.28454575
81CSNK1G10.27605199
82PDPK10.27449097
83PRKD30.26351925
84MAPK130.26068751
85CSNK1A10.25802042
86WNK10.25535993
87MAP2K70.24480620
88ERBB40.24070712
89GRK50.23481521
90TGFBR20.23012534
91NEK60.22929108
92ITK0.22243519
93PIK3CA0.21551972
94MAP3K90.20863572
95CAMK40.20818910
96AKT20.20715157
97IRAK30.19540743
98PAK30.19280173
99NTRK10.17439430
100IGF1R0.17006834

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.63864393
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.52899335
3Nitrogen metabolism_Homo sapiens_hsa009102.86364639
4Sphingolipid metabolism_Homo sapiens_hsa006002.85971641
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.63276864
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.60218993
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54194541
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.50041031
9ABC transporters_Homo sapiens_hsa020102.46967832
10Nicotine addiction_Homo sapiens_hsa050331.98908862
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98555124
12Proteasome_Homo sapiens_hsa030501.93451812
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72330966
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67574550
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64707657
16Dorso-ventral axis formation_Homo sapiens_hsa043201.64184216
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.56576168
18Ovarian steroidogenesis_Homo sapiens_hsa049131.56064536
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53527060
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52734609
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47743756
22Circadian rhythm_Homo sapiens_hsa047101.44430826
23GABAergic synapse_Homo sapiens_hsa047271.44365288
24Butanoate metabolism_Homo sapiens_hsa006501.41595362
25Homologous recombination_Homo sapiens_hsa034401.38479949
26Glycerolipid metabolism_Homo sapiens_hsa005611.38327733
27Propanoate metabolism_Homo sapiens_hsa006401.31310411
28Tryptophan metabolism_Homo sapiens_hsa003801.30116380
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.28273675
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25972249
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25132963
32Sulfur relay system_Homo sapiens_hsa041221.24888310
33Linoleic acid metabolism_Homo sapiens_hsa005911.19640519
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.18291943
35Serotonergic synapse_Homo sapiens_hsa047261.16492062
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15672809
37Tyrosine metabolism_Homo sapiens_hsa003501.15432138
38Morphine addiction_Homo sapiens_hsa050321.08264060
39Selenocompound metabolism_Homo sapiens_hsa004501.06797097
40Chemical carcinogenesis_Homo sapiens_hsa052041.04078295
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00804057
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00356933
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98286138
44Retinol metabolism_Homo sapiens_hsa008300.96843744
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94884599
46Lysosome_Homo sapiens_hsa041420.91308840
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.89482161
48Renin-angiotensin system_Homo sapiens_hsa046140.89077645
49Cell cycle_Homo sapiens_hsa041100.88890188
50Calcium signaling pathway_Homo sapiens_hsa040200.87856480
51Basal transcription factors_Homo sapiens_hsa030220.87606943
52Nucleotide excision repair_Homo sapiens_hsa034200.85158596
53p53 signaling pathway_Homo sapiens_hsa041150.83318147
54Salivary secretion_Homo sapiens_hsa049700.82567305
55Fatty acid elongation_Homo sapiens_hsa000620.82182498
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.81860776
57Arginine and proline metabolism_Homo sapiens_hsa003300.79749068
58Histidine metabolism_Homo sapiens_hsa003400.79112999
59N-Glycan biosynthesis_Homo sapiens_hsa005100.78732731
60ECM-receptor interaction_Homo sapiens_hsa045120.77084615
61Galactose metabolism_Homo sapiens_hsa000520.73157439
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69822868
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.65055551
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61189407
65Fanconi anemia pathway_Homo sapiens_hsa034600.61116596
66Oxidative phosphorylation_Homo sapiens_hsa001900.61061764
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61049429
68Collecting duct acid secretion_Homo sapiens_hsa049660.60756584
69Metabolic pathways_Homo sapiens_hsa011000.58043971
70Folate biosynthesis_Homo sapiens_hsa007900.55103063
71Ether lipid metabolism_Homo sapiens_hsa005650.53791473
72DNA replication_Homo sapiens_hsa030300.52771197
73Taste transduction_Homo sapiens_hsa047420.51583676
74Phenylalanine metabolism_Homo sapiens_hsa003600.49594647
75Peroxisome_Homo sapiens_hsa041460.49055461
76Starch and sucrose metabolism_Homo sapiens_hsa005000.48969174
77One carbon pool by folate_Homo sapiens_hsa006700.47815344
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47791343
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47649219
80Sulfur metabolism_Homo sapiens_hsa009200.46971276
81Caffeine metabolism_Homo sapiens_hsa002320.45944645
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45088267
83Base excision repair_Homo sapiens_hsa034100.44239765
84Glutathione metabolism_Homo sapiens_hsa004800.43570083
85Vitamin digestion and absorption_Homo sapiens_hsa049770.41407867
86Olfactory transduction_Homo sapiens_hsa047400.39493869
87Fructose and mannose metabolism_Homo sapiens_hsa000510.38511776
88TGF-beta signaling pathway_Homo sapiens_hsa043500.37881541
89Protein export_Homo sapiens_hsa030600.37680876
90Bile secretion_Homo sapiens_hsa049760.36760474
91Glutamatergic synapse_Homo sapiens_hsa047240.35189574
92Circadian entrainment_Homo sapiens_hsa047130.32945762
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.32619724
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32301558
95beta-Alanine metabolism_Homo sapiens_hsa004100.31770599
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31260236
97Huntingtons disease_Homo sapiens_hsa050160.31137369
98Gastric acid secretion_Homo sapiens_hsa049710.30687009
99Pyrimidine metabolism_Homo sapiens_hsa002400.30376547
100Arginine biosynthesis_Homo sapiens_hsa002200.29062975

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