ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of guanylate cyclase activity (GO:0031284)	7.19448415
2	regulation of guanylate cyclase activity (GO:0031282)	6.44139668
3	antigen processing and presentation via MHC class Ib (GO:0002475)	6.22023378
4	sphingoid metabolic process (GO:0046519)	6.12150091
5	sphingosine metabolic process (GO:0006670)	6.06619807
6	DNA deamination (GO:0045006)	5.85809961
7	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.80662323
8	diol metabolic process (GO:0034311)	5.52296731
9	cytidine metabolic process (GO:0046087)	5.22479101
10	cytidine catabolic process (GO:0006216)	5.22479101
11	cytidine deamination (GO:0009972)	5.22479101
12	positive regulation of cGMP biosynthetic process (GO:0030828)	4.92097470
13	pseudouridine synthesis (GO:0001522)	4.89216969
14	peristalsis (GO:0030432)	4.57308677
15	regulation of cGMP biosynthetic process (GO:0030826)	4.56499890
16	negative regulation of organelle assembly (GO:1902116)	4.51114354
17	amino acid salvage (GO:0043102)	4.47869098
18	L-methionine salvage (GO:0071267)	4.47869098
19	L-methionine biosynthetic process (GO:0071265)	4.47869098
20	regulation of meiosis I (GO:0060631)	4.36586734
21	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.36090245
22	positive regulation of cGMP metabolic process (GO:0030825)	4.33081975
23	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.30526088
24	DNA methylation involved in gamete generation (GO:0043046)	4.27761190
25	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	4.19533271
26	sulfate transport (GO:0008272)	4.13673231
27	regulation of cGMP metabolic process (GO:0030823)	3.97834661
28	protein-chromophore linkage (GO:0018298)	3.97317739
29	lipopolysaccharide biosynthetic process (GO:0009103)	3.78285524
30	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.74225108
31	piRNA metabolic process (GO:0034587)	3.69734896
32	atrial cardiac muscle cell action potential (GO:0086014)	3.69583933
33	urinary tract smooth muscle contraction (GO:0014848)	3.63963018
34	gap junction assembly (GO:0016264)	3.63836900
35	rhodopsin mediated signaling pathway (GO:0016056)	3.63342873
36	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.55266981
37	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.54953503
38	kidney morphogenesis (GO:0060993)	3.52167327
39	SMAD protein complex assembly (GO:0007183)	3.49587742
40	regulation of hippo signaling (GO:0035330)	3.46876434
41	phasic smooth muscle contraction (GO:0014821)	3.42114992
42	pericardium development (GO:0060039)	3.41513755
43	postsynaptic membrane organization (GO:0001941)	3.41239314
44	methionine biosynthetic process (GO:0009086)	3.35920758
45	tachykinin receptor signaling pathway (GO:0007217)	3.35906895
46	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.32850766
47	positive regulation of antigen processing and presentation (GO:0002579)	3.30195337
48	signal peptide processing (GO:0006465)	3.24203056
49	endosome to pigment granule transport (GO:0043485)	3.21129383
50	endosome to melanosome transport (GO:0035646)	3.21129383
51	arginine catabolic process (GO:0006527)	3.20843209
52	parturition (GO:0007567)	3.20570787
53	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.14418096
54	regulation of microtubule-based movement (GO:0060632)	3.13243822
55	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.12252116
56	positive regulation of cyclase activity (GO:0031281)	3.11958645
57	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.10031154
58	positive regulation of lyase activity (GO:0051349)	3.09629091
59	regulation of uterine smooth muscle contraction (GO:0070472)	3.07039406
60	flavonoid metabolic process (GO:0009812)	3.00741540
61	response to redox state (GO:0051775)	2.94171272
62	lipopolysaccharide metabolic process (GO:0008653)	2.92069853
63	response to nitrosative stress (GO:0051409)	2.88131420
64	adult feeding behavior (GO:0008343)	2.88126246
65	methionine metabolic process (GO:0006555)	2.85189271
66	multicellular organismal movement (GO:0050879)	2.84512531
67	musculoskeletal movement (GO:0050881)	2.84512531
68	positive regulation of natural killer cell differentiation (GO:0032825)	2.81863579
69	sulfur compound transport (GO:0072348)	2.81248826
70	nodal signaling pathway (GO:0038092)	2.79058885
71	regulation of respiratory system process (GO:0044065)	2.75070853
72	positive regulation of respiratory burst (GO:0060267)	2.74583659
73	growth hormone secretion (GO:0030252)	2.74067110
74	positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	2.73774865
75	negative regulation of systemic arterial blood pressure (GO:0003085)	2.73128129
76	serotonin receptor signaling pathway (GO:0007210)	2.71847432
77	proteasome assembly (GO:0043248)	2.71107550
78	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.69778747
79	sulfation (GO:0051923)	2.68554999
80	sulfate transmembrane transport (GO:1902358)	2.67747985
81	regulation of appetite (GO:0032098)	2.67186222
82	nucleoside salvage (GO:0043174)	2.65464951
83	diterpenoid biosynthetic process (GO:0016102)	2.63912876
84	negative regulation of interleukin-1 beta production (GO:0032691)	2.63180700
85	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.61676120
86	keratinization (GO:0031424)	2.59954523
87	regulation of cilium movement (GO:0003352)	2.59192157
88	DNA-dependent DNA replication (GO:0006261)	2.56801481
89	cornea development in camera-type eye (GO:0061303)	2.56510476
90	membrane raft organization (GO:0031579)	2.55397244
91	L-phenylalanine catabolic process (GO:0006559)	2.53261228
92	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.53261228
93	mannosylation (GO:0097502)	2.51207919
94	positive regulation of ERBB signaling pathway (GO:1901186)	2.51072527
95	regulation of response to food (GO:0032095)	2.50787530
96	sympathetic nervous system development (GO:0048485)	2.50748952
97	negative regulation of blood pressure (GO:0045776)	2.49641638
98	vitamin transmembrane transport (GO:0035461)	2.48894495
99	antigen processing and presentation of endogenous antigen (GO:0019883)	2.44641283
100	cellular ketone body metabolic process (GO:0046950)	2.44121146

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	3.71999957
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.11800837
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00973690
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.87885727
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.46930732
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.32748489
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.24723678
8	TP53_18474530_ChIP-ChIP_U2OS_Human	2.21512309
9	P300_19829295_ChIP-Seq_ESCs_Human	2.19732831
10	VDR_22108803_ChIP-Seq_LS180_Human	2.13631049
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.09816334
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.06608109
13	CJUN_26792858_Chip-Seq_BT549_Human	2.06082909
14	TP53_16413492_ChIP-PET_HCT116_Human	2.04039883
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.02916504
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.97361529
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93301500
18	STAT3_23295773_ChIP-Seq_U87_Human	1.85958667
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.80046083
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.75754415
21	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.73860744
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.71110327
23	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.70300325
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68840584
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68740809
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.68438976
27	TCF4_23295773_ChIP-Seq_U87_Human	1.66794444
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.60305904
29	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.59265856
30	EZH2_22144423_ChIP-Seq_EOC_Human	1.59093463
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58193949
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.58193949
33	AR_25329375_ChIP-Seq_VCAP_Human	1.57464270
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56913906
35	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.56608232
36	FUS_26573619_Chip-Seq_HEK293_Human	1.53002432
37	EWS_26573619_Chip-Seq_HEK293_Human	1.52457981
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51279152
39	TCF4_22108803_ChIP-Seq_LS180_Human	1.49294229
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.48084028
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.47707913
42	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.46855814
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46261623
44	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.45659065
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43200686
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43200686
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.43189056
48	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.42198708
49	HOXB7_26014856_ChIP-Seq_BT474_Human	1.38330577
50	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.37516246
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36548441
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35610066
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32680235
54	TP63_23658742_ChIP-Seq_EP156T_Human	1.31654369
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30854190
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30854190
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.30762942
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30081408
59	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.28822304
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27553574
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27553574
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26651104
63	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.25209432
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.25068467
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24775996
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22503043
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19768765
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.18740080
69	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.17493392
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16857666
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16007107
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.14795281
73	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13158776
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12452314
75	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.11514681
76	NCOR_22424771_ChIP-Seq_293T_Human	1.10867874
77	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09072475
78	TBL1_22424771_ChIP-Seq_293T_Human	1.08067090
79	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.07592526
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07437544
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.07097195
82	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.06877511
83	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.06270646
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06076455
85	BRD4_25478319_ChIP-Seq_HGPS_Human	1.05063784
86	JUN_21703547_ChIP-Seq_K562_Human	1.04351066
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04002457
88	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.03917966
89	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03852631
90	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.03106509
91	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01605232
92	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01396078
93	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.00088874
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.99872584
95	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.99646618
96	CBP_21632823_ChIP-Seq_H3396_Human	0.99121385
97	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.97642978
98	NFYB_21822215_ChIP-Seq_K562_Human	0.97258525
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96529395
100	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.96299922

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	5.24090390
2	MP0003195_calcinosis	5.12743131
3	MP0003646_muscle_fatigue	5.01181895
4	MP0003950_abnormal_plasma_membrane	4.45279409
5	MP0002837_dystrophic_cardiac_calcinosis	4.03255537
6	MP0000569_abnormal_digit_pigmentation	3.82259400
7	MP0001348_abnormal_lacrimal_gland	3.34806660
8	MP0005171_absent_coat_pigmentation	2.96818163
9	MP0009697_abnormal_copulation	2.76581207
10	MP0005167_abnormal_blood-brain_barrier	2.57770078
11	MP0002102_abnormal_ear_morphology	2.52268250
12	MP0002735_abnormal_chemical_nociception	2.47732927
13	MP0003136_yellow_coat_color	2.42532963
14	MP0010386_abnormal_urinary_bladder	2.37082380
15	MP0003718_maternal_effect	2.24013799
16	MP0004043_abnormal_pH_regulation	2.15586481
17	MP0005085_abnormal_gallbladder_physiolo	2.11647659
18	MP0006276_abnormal_autonomic_nervous	1.99619329
19	MP0010678_abnormal_skin_adnexa	1.93383316
20	MP0003890_abnormal_embryonic-extraembry	1.87315150
21	MP0003252_abnormal_bile_duct	1.85293472
22	MP0009840_abnormal_foam_cell	1.81301948
23	MP0008872_abnormal_physiological_respon	1.77608103
24	MP0003045_fibrosis	1.75730703
25	MP0002653_abnormal_ependyma_morphology	1.75307726
26	MP0003137_abnormal_impulse_conducting	1.70146621
27	MP0000383_abnormal_hair_follicle	1.64861410
28	MP0002138_abnormal_hepatobiliary_system	1.63197668
29	MP0003879_abnormal_hair_cell	1.61126837
30	MP0005257_abnormal_intraocular_pressure	1.58934950
31	MP0004233_abnormal_muscle_weight	1.57255200
32	MP0005551_abnormal_eye_electrophysiolog	1.54700122
33	MP0004272_abnormal_basement_membrane	1.54450084
34	MP0001970_abnormal_pain_threshold	1.50023220
35	MP0005360_urolithiasis	1.48497337
36	MP0005395_other_phenotype	1.45188703
37	MP0001501_abnormal_sleep_pattern	1.43211575
38	MP0002733_abnormal_thermal_nociception	1.34184161
39	MP0002168_other_aberrant_phenotype	1.33978937
40	MP0005646_abnormal_pituitary_gland	1.26631772
41	MP0000427_abnormal_hair_cycle	1.22977019
42	MP0002139_abnormal_hepatobiliary_system	1.21872618
43	MP0006054_spinal_hemorrhage	1.21531270
44	MP0009046_muscle_twitch	1.15631027
45	MP0000230_abnormal_systemic_arterial	1.13402605
46	MP0005174_abnormal_tail_pigmentation	1.10261847
47	MP0005084_abnormal_gallbladder_morpholo	1.09535685
48	MP0001984_abnormal_olfaction	1.07255648
49	MP0004084_abnormal_cardiac_muscle	1.05909584
50	MP0008875_abnormal_xenobiotic_pharmacok	1.05050249
51	MP0001849_ear_inflammation	1.02224933
52	MP0000749_muscle_degeneration	1.02057360
53	MP0001486_abnormal_startle_reflex	1.00213216
54	MP0006082_CNS_inflammation	0.95628085
55	MP0003183_abnormal_peptide_metabolism	0.95187749
56	MP0004381_abnormal_hair_follicle	0.88432384
57	MP0000647_abnormal_sebaceous_gland	0.87296996
58	MP0005386_behavior/neurological_phenoty	0.86434799
59	MP0004924_abnormal_behavior	0.86434799
60	MP0003880_abnormal_central_pattern	0.85533454
61	MP0000015_abnormal_ear_pigmentation	0.82773728
62	MP0002876_abnormal_thyroid_physiology	0.82346059
63	MP0004085_abnormal_heartbeat	0.82192703
64	MP0003806_abnormal_nucleotide_metabolis	0.81151099
65	MP0001529_abnormal_vocalization	0.81098152
66	MP0005075_abnormal_melanosome_morpholog	0.80079126
67	MP0005670_abnormal_white_adipose	0.79433619
68	MP0001905_abnormal_dopamine_level	0.78957987
69	MP0004782_abnormal_surfactant_physiolog	0.78683032
70	MP0002095_abnormal_skin_pigmentation	0.78137377
71	MP0002938_white_spotting	0.77073659
72	MP0001664_abnormal_digestion	0.75671391
73	MP0009780_abnormal_chondrocyte_physiolo	0.75643061
74	MP0002332_abnormal_exercise_endurance	0.74154960
75	MP0005410_abnormal_fertilization	0.73997370
76	MP0002736_abnormal_nociception_after	0.73622079
77	MP0001324_abnormal_eye_pigmentation	0.73303037
78	MP0005620_abnormal_muscle_contractility	0.71431613
79	MP0002734_abnormal_mechanical_nocicepti	0.68852626
80	MP0002160_abnormal_reproductive_system	0.67986772
81	MP0002254_reproductive_system_inflammat	0.67869023
82	MP0000534_abnormal_ureter_morphology	0.66145990
83	MP0005266_abnormal_metabolism	0.65563656
84	MP0008775_abnormal_heart_ventricle	0.64440163
85	MP0000538_abnormal_urinary_bladder	0.62705292
86	MP0002269_muscular_atrophy	0.62189118
87	MP0005645_abnormal_hypothalamus_physiol	0.61335534
88	MP0010329_abnormal_lipoprotein_level	0.59992032
89	MP0004036_abnormal_muscle_relaxation	0.58918176
90	MP0009250_abnormal_appendicular_skeleto	0.56957668
91	MP0009745_abnormal_behavioral_response	0.56414521
92	MP0005365_abnormal_bile_salt	0.55605809
93	MP0003941_abnormal_skin_development	0.55046547
94	MP0002272_abnormal_nervous_system	0.54212278
95	MP0005197_abnormal_uvea_morphology	0.54079586
96	MP0002972_abnormal_cardiac_muscle	0.53652079
97	MP0005595_abnormal_vascular_smooth	0.51647905
98	MP0002928_abnormal_bile_duct	0.48197597
99	MP0005389_reproductive_system_phenotype	0.47375174
100	MP0004215_abnormal_myocardial_fiber	0.47353063

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Breast hypoplasia (HP:0003187)	7.06684452
2	Microretrognathia (HP:0000308)	5.31052191
3	Pancreatic cysts (HP:0001737)	4.06186130
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.92154829
5	Aplasia/Hypoplasia of the sternum (HP:0006714)	3.85341859
6	Hyperventilation (HP:0002883)	3.76894191
7	Diastasis recti (HP:0001540)	3.71818166
8	Amelogenesis imperfecta (HP:0000705)	3.61445872
9	Parakeratosis (HP:0001036)	3.58776427
10	Patellar aplasia (HP:0006443)	3.56866156
11	Aplasia/Hypoplasia of the patella (HP:0006498)	3.38314981
12	Type II lissencephaly (HP:0007260)	3.19311323
13	Inability to walk (HP:0002540)	3.18867850
14	Poor head control (HP:0002421)	3.17643103
15	Congenital ichthyosiform erythroderma (HP:0007431)	3.14634319
16	Congenital stationary night blindness (HP:0007642)	3.12002239
17	Abnormality of liposaccharide metabolism (HP:0010968)	3.00780872
18	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.00780872
19	Abnormality of glycolipid metabolism (HP:0010969)	3.00780872
20	Pancreatic fibrosis (HP:0100732)	2.95375191
21	Poor speech (HP:0002465)	2.94805820
22	Abnormality of the renal cortex (HP:0011035)	2.91560983
23	Chorioretinal atrophy (HP:0000533)	2.80235619
24	True hermaphroditism (HP:0010459)	2.77063994
25	Hydroxyprolinuria (HP:0003080)	2.71757919
26	Abnormality of proline metabolism (HP:0010907)	2.71757919
27	Nephronophthisis (HP:0000090)	2.67531209
28	Albinism (HP:0001022)	2.66734004
29	Slender long bone (HP:0003100)	2.64309442
30	Recurrent pneumonia (HP:0006532)	2.61877784
31	Large eyes (HP:0001090)	2.61707444
32	Abnormality of the renal medulla (HP:0100957)	2.52805342
33	Acanthocytosis (HP:0001927)	2.51520764
34	Microtia (HP:0008551)	2.51451073
35	Lissencephaly (HP:0001339)	2.48319449
36	Medial flaring of the eyebrow (HP:0010747)	2.45393338
37	Congenital primary aphakia (HP:0007707)	2.40854317
38	Progressive inability to walk (HP:0002505)	2.38555380
39	Hypokinesia (HP:0002375)	2.38475328
40	Gonadotropin excess (HP:0000837)	2.34064537
41	Coxa vara (HP:0002812)	2.33128038
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.32776427
43	Gait imbalance (HP:0002141)	2.31860937
44	Molar tooth sign on MRI (HP:0002419)	2.29746054
45	Abnormality of midbrain morphology (HP:0002418)	2.29746054
46	Myokymia (HP:0002411)	2.29344086
47	Global brain atrophy (HP:0002283)	2.26958786
48	Opisthotonus (HP:0002179)	2.25299177
49	Increased density of long bones (HP:0006392)	2.22914363
50	Tubular atrophy (HP:0000092)	2.20491967
51	Congenital sensorineural hearing impairment (HP:0008527)	2.20351162
52	Long foot (HP:0001833)	2.20111175
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19755433
54	Nephrogenic diabetes insipidus (HP:0009806)	2.17509702
55	Type I transferrin isoform profile (HP:0003642)	2.15005836
56	Furrowed tongue (HP:0000221)	2.12714326
57	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.08746793
58	Abnormality of the pons (HP:0007361)	2.08560772
59	Abnormality of the clitoris (HP:0000056)	2.08042655
60	Female pseudohermaphroditism (HP:0010458)	2.07773963
61	Depressed nasal tip (HP:0000437)	2.04781713
62	Genu varum (HP:0002970)	2.04774603
63	Scrotal hypoplasia (HP:0000046)	2.01955058
64	Abnormality of macular pigmentation (HP:0008002)	2.00984686
65	Birth length less than 3rd percentile (HP:0003561)	11.3317408
66	Breast aplasia (HP:0100783)	1.97713109
67	Hypoalbuminemia (HP:0003073)	1.97129634
68	Abnormal albumin level (HP:0012116)	1.97129634
69	Spondylolisthesis (HP:0003302)	1.96338783
70	Widely spaced teeth (HP:0000687)	1.95393200
71	Fair hair (HP:0002286)	1.94312943
72	Severe visual impairment (HP:0001141)	1.90470650
73	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.90034013
74	Hypoplasia of the maxilla (HP:0000327)	1.88854869
75	Cystic liver disease (HP:0006706)	1.87337115
76	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.86050635
77	Chronic hepatic failure (HP:0100626)	1.81867219
78	Retinal dysplasia (HP:0007973)	1.81746371
79	Protruding tongue (HP:0010808)	1.80576584
80	Palpitations (HP:0001962)	1.80048691
81	Hypoplasia of the pons (HP:0012110)	1.78112230
82	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.77061814
83	Attenuation of retinal blood vessels (HP:0007843)	1.76842691
84	Vaginal atresia (HP:0000148)	1.76341131
85	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.75830246
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73205415
87	Genital tract atresia (HP:0001827)	1.73166679
88	Hypophosphatemic rickets (HP:0004912)	1.72852941
89	Aplastic anemia (HP:0001915)	1.72734085
90	Erythroderma (HP:0001019)	1.72607496
91	Short foot (HP:0001773)	1.68993758
92	Difficulty walking (HP:0002355)	1.68991375
93	Poor coordination (HP:0002370)	1.68291205
94	Pendular nystagmus (HP:0012043)	1.67132375
95	Absent speech (HP:0001344)	1.66320735
96	Anterior segment dysgenesis (HP:0007700)	1.66274902
97	Aplasia/hypoplasia of the uterus (HP:0008684)	1.65233431
98	Pigmentary retinal degeneration (HP:0001146)	1.64863152
99	Upper limb muscle weakness (HP:0003484)	1.63219120
100	Long nose (HP:0003189)	1.60813016

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.60030580
2	BMPR1B	4.75463545
3	LATS1	4.47275742
4	STK38L	4.03194329
5	CASK	3.66536547
6	DAPK2	3.58755517
7	FRK	3.51792458
8	ZAK	3.19944363
9	MST4	2.33655002
10	TGFBR1	2.07362844
11	MELK	1.99309826
12	MAP4K2	1.96767981
13	NEK9	1.96699637
14	LATS2	1.90765833
15	NME1	1.86098850
16	STK38	1.84182061
17	MST1R	1.77825576
18	BCR	1.54855016
19	TXK	1.53936736
20	CAMKK1	1.48845400
21	ADRBK1	1.46564164
22	MET	1.41082373
23	MYLK	1.24061674
24	MAPKAPK3	1.23035039
25	GRK7	1.22388641
26	EPHA2	1.17966560
27	MAP3K12	1.16074914
28	WNK4	1.13224634
29	ADRBK2	1.12744129
30	MAP2K1	1.06422197
31	TRIM28	1.03984138
32	PDK2	0.98762711
33	MAP2K6	0.91342351
34	NEK1	0.86893342
35	NEK2	0.86333094
36	PRKAA2	0.85917098
37	CSNK1A1L	0.83586615
38	BCKDK	0.82218169
39	PTK2B	0.77068041
40	KSR2	0.76581357
41	STK16	0.75279857
42	CAMKK2	0.74685365
43	MAP3K7	0.71429976
44	TRPM7	0.66424901
45	MAP3K2	0.66038572
46	EIF2AK3	0.65807313
47	PIK3CG	0.60470443
48	ABL2	0.59868327
49	MKNK2	0.59799477
50	STK3	0.59609398
51	CAMK2A	0.57749417
52	PLK2	0.56819852
53	GRK1	0.55854647
54	PKN1	0.53801910
55	PINK1	0.53459010
56	CAMK1	0.50302289
57	FLT3	0.45685960
58	PRKG2	0.45173906
59	PRKCE	0.45130313
60	PBK	0.44196110
61	TLK1	0.43504667
62	CSNK1G3	0.42594512
63	KDR	0.42064864
64	ARAF	0.41484628
65	BMX	0.40010688
66	PAK2	0.36559145
67	PLK3	0.35028465
68	CSNK1G2	0.34954233
69	PAK6	0.34660142
70	OXSR1	0.34600781
71	MOS	0.33916215
72	CAMK1D	0.33799584
73	DAPK1	0.33336443
74	BRSK2	0.33163055
75	TAOK3	0.32253436
76	MAP2K2	0.32003925
77	PLK1	0.30898242
78	TTK	0.30178035
79	NLK	0.28534295
80	ERBB3	0.28454575
81	CSNK1G1	0.27605199
82	PDPK1	0.27449097
83	PRKD3	0.26351925
84	MAPK13	0.26068751
85	CSNK1A1	0.25802042
86	WNK1	0.25535993
87	MAP2K7	0.24480620
88	ERBB4	0.24070712
89	GRK5	0.23481521
90	TGFBR2	0.23012534
91	NEK6	0.22929108
92	ITK	0.22243519
93	PIK3CA	0.21551972
94	MAP3K9	0.20863572
95	CAMK4	0.20818910
96	AKT2	0.20715157
97	IRAK3	0.19540743
98	PAK3	0.19280173
99	NTRK1	0.17439430
100	IGF1R	0.17006834

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	4.63864393
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.52899335
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.86364639
4	Sphingolipid metabolism_Homo sapiens_hsa00600	2.85971641
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.63276864
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.60218993
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.54194541
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.50041031
9	ABC transporters_Homo sapiens_hsa02010	2.46967832
10	Nicotine addiction_Homo sapiens_hsa05033	1.98908862
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.98555124
12	Proteasome_Homo sapiens_hsa03050	1.93451812
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.72330966
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.67574550
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.64707657
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.64184216
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.56576168
18	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.56064536
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53527060
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.52734609
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.47743756
22	Circadian rhythm_Homo sapiens_hsa04710	1.44430826
23	GABAergic synapse_Homo sapiens_hsa04727	1.44365288
24	Butanoate metabolism_Homo sapiens_hsa00650	1.41595362
25	Homologous recombination_Homo sapiens_hsa03440	1.38479949
26	Glycerolipid metabolism_Homo sapiens_hsa00561	1.38327733
27	Propanoate metabolism_Homo sapiens_hsa00640	1.31310411
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.30116380
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28273675
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25972249
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25132963
32	Sulfur relay system_Homo sapiens_hsa04122	1.24888310
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19640519
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18291943
35	Serotonergic synapse_Homo sapiens_hsa04726	1.16492062
36	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.15672809
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.15432138
38	Morphine addiction_Homo sapiens_hsa05032	1.08264060
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.06797097
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04078295
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.00804057
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.00356933
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98286138
44	Retinol metabolism_Homo sapiens_hsa00830	0.96843744
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94884599
46	Lysosome_Homo sapiens_hsa04142	0.91308840
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89482161
48	Renin-angiotensin system_Homo sapiens_hsa04614	0.89077645
49	Cell cycle_Homo sapiens_hsa04110	0.88890188
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.87856480
51	Basal transcription factors_Homo sapiens_hsa03022	0.87606943
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.85158596
53	p53 signaling pathway_Homo sapiens_hsa04115	0.83318147
54	Salivary secretion_Homo sapiens_hsa04970	0.82567305
55	Fatty acid elongation_Homo sapiens_hsa00062	0.82182498
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.81860776
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79749068
58	Histidine metabolism_Homo sapiens_hsa00340	0.79112999
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.78732731
60	ECM-receptor interaction_Homo sapiens_hsa04512	0.77084615
61	Galactose metabolism_Homo sapiens_hsa00052	0.73157439
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69822868
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65055551
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61189407
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61116596
66	Oxidative phosphorylation_Homo sapiens_hsa00190	0.61061764
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61049429
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60756584
69	Metabolic pathways_Homo sapiens_hsa01100	0.58043971
70	Folate biosynthesis_Homo sapiens_hsa00790	0.55103063
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.53791473
72	DNA replication_Homo sapiens_hsa03030	0.52771197
73	Taste transduction_Homo sapiens_hsa04742	0.51583676
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49594647
75	Peroxisome_Homo sapiens_hsa04146	0.49055461
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.48969174
77	One carbon pool by folate_Homo sapiens_hsa00670	0.47815344
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.47791343
79	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.47649219
80	Sulfur metabolism_Homo sapiens_hsa00920	0.46971276
81	Caffeine metabolism_Homo sapiens_hsa00232	0.45944645
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45088267
83	Base excision repair_Homo sapiens_hsa03410	0.44239765
84	Glutathione metabolism_Homo sapiens_hsa00480	0.43570083
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41407867
86	Olfactory transduction_Homo sapiens_hsa04740	0.39493869
87	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.38511776
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37881541
89	Protein export_Homo sapiens_hsa03060	0.37680876
90	Bile secretion_Homo sapiens_hsa04976	0.36760474
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.35189574
92	Circadian entrainment_Homo sapiens_hsa04713	0.32945762
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32619724
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32301558
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31770599
96	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.31260236
97	Huntingtons disease_Homo sapiens_hsa05016	0.31137369
98	Gastric acid secretion_Homo sapiens_hsa04971	0.30687009
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30376547
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.29062975

CEACAMP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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