CEACAMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.55255808
2cell morphogenesis involved in neuron differentiation (GO:0048667)6.28759908
3positive thymic T cell selection (GO:0045059)5.60540590
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.55910756
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.50590203
6post-embryonic morphogenesis (GO:0009886)5.40294255
7regulation of B cell receptor signaling pathway (GO:0050855)5.30207418
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.28719345
9negative thymic T cell selection (GO:0045060)5.11702568
10negative T cell selection (GO:0043383)5.00305768
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95992067
12negative regulation of cell killing (GO:0031342)4.85067978
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85067978
14positive T cell selection (GO:0043368)4.78178835
15B cell receptor signaling pathway (GO:0050853)4.77566852
16positive regulation of gamma-delta T cell activation (GO:0046645)4.67970197
17response to pheromone (GO:0019236)4.55454375
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44146331
19regulation of dendritic cell antigen processing and presentation (GO:0002604)4.23701964
20tolerance induction (GO:0002507)4.12263449
21thymic T cell selection (GO:0045061)4.02476232
22negative regulation of T cell mediated immunity (GO:0002710)3.89030884
23regulation of regulatory T cell differentiation (GO:0045589)3.77511682
24chaperone mediated protein folding requiring cofactor (GO:0051085)3.69689437
25activated T cell proliferation (GO:0050798)3.67772858
26energy homeostasis (GO:0097009)3.64206470
27regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57072709
28T cell selection (GO:0045058)3.56009997
29response to interleukin-15 (GO:0070672)3.55459521
30defense response to protozoan (GO:0042832)3.53146295
31cellular response to interleukin-15 (GO:0071350)3.52991899
32immunoglobulin mediated immune response (GO:0016064)3.48077937
33regulation of antigen processing and presentation (GO:0002577)3.46024238
34histone H3-K9 modification (GO:0061647)3.44006479
35regulation of T cell tolerance induction (GO:0002664)3.41957496
36positive regulation of antigen processing and presentation (GO:0002579)3.40182206
37cellular extravasation (GO:0045123)3.39319428
38antigen receptor-mediated signaling pathway (GO:0050851)3.36284431
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.33300431
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30301388
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26966301
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.26966301
43modulation by symbiont of host immune response (GO:0052553)3.26966301
44positive regulation by symbiont of host defense response (GO:0052509)3.26966301
45modulation by symbiont of host defense response (GO:0052031)3.26966301
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26966301
47positive regulation of type 2 immune response (GO:0002830)3.26125069
48cell wall macromolecule catabolic process (GO:0016998)3.25020454
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24420928
50negative regulation of T-helper cell differentiation (GO:0045623)3.24420928
51positive regulation of T cell mediated cytotoxicity (GO:0001916)3.24296050
52base-excision repair, AP site formation (GO:0006285)3.24229242
53negative regulation of cAMP-mediated signaling (GO:0043951)3.23820644
54positive regulation of tolerance induction (GO:0002645)3.22813912
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19285333
56response to protozoan (GO:0001562)3.18530764
57regulation of T cell mediated cytotoxicity (GO:0001914)3.13759401
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11573081
59regulation of alpha-beta T cell proliferation (GO:0046640)3.11125978
60positive regulation of CREB transcription factor activity (GO:0032793)3.11092789
61regulation of gamma-delta T cell activation (GO:0046643)3.08981360
62regulation of tolerance induction (GO:0002643)3.08825565
63regulation of natural killer cell mediated immunity (GO:0002715)3.08408816
64regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.08408816
65G-protein coupled receptor internalization (GO:0002031)3.06638041
66respiratory burst (GO:0045730)3.05845028
67mast cell activation (GO:0045576)3.05752148
68mitochondrial DNA replication (GO:0006264)3.05112646
69regulation of B cell differentiation (GO:0045577)2.99976311
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97467210
71leukocyte aggregation (GO:0070486)2.96127523
72leukocyte degranulation (GO:0043299)2.94740664
73regulation of cell killing (GO:0031341)2.94331315
74T cell receptor signaling pathway (GO:0050852)2.94191654
75positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93736299
76regulation of isotype switching to IgG isotypes (GO:0048302)2.91566893
77negative regulation of leukocyte mediated immunity (GO:0002704)2.90140131
78lymphocyte homeostasis (GO:0002260)2.90010175
79positive regulation of humoral immune response (GO:0002922)2.89323058
80polyamine biosynthetic process (GO:0006596)2.89028353
81regulation of leukocyte mediated cytotoxicity (GO:0001910)2.88049080
82T cell migration (GO:0072678)2.87492059
83mannose metabolic process (GO:0006013)2.84208130
84positive regulation of cell killing (GO:0031343)2.83834366
85negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83761345
86oogenesis (GO:0048477)2.76583104
87type I interferon signaling pathway (GO:0060337)2.76482076
88cellular response to type I interferon (GO:0071357)2.76482076
89regulation of gamma-delta T cell differentiation (GO:0045586)2.75315076
90purine deoxyribonucleotide catabolic process (GO:0009155)2.74959964
91response to type I interferon (GO:0034340)2.74698738
92negative regulation of B cell apoptotic process (GO:0002903)2.71537974
93positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.71354937
94B cell homeostasis (GO:0001782)2.70235719
95outer ear morphogenesis (GO:0042473)2.69586608
96negative regulation of interleukin-6 production (GO:0032715)2.69020962
97negative regulation of innate immune response (GO:0045824)2.68995683
98positive regulation of macrophage cytokine production (GO:0060907)2.68827946
99histone H3-K9 methylation (GO:0051567)2.68030784
100cell wall macromolecule metabolic process (GO:0044036)2.67265837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.61594127
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.23263651
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.60694073
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.51752721
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29368609
6EZH2_22144423_ChIP-Seq_EOC_Human3.22024063
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19769739
8RUNX_20019798_ChIP-Seq_JUKART_Human3.09492174
9VDR_22108803_ChIP-Seq_LS180_Human3.09484929
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00149434
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91312820
12MYB_26560356_Chip-Seq_TH2_Human2.82640887
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57012679
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.49368800
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40881729
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38824439
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.36989043
18MYB_26560356_Chip-Seq_TH1_Human2.30881417
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.26103766
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25091957
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11313382
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10267005
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99743386
24MAF_26560356_Chip-Seq_TH1_Human1.99147661
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87529886
26SPI1_23547873_ChIP-Seq_NB4_Human1.86274850
27GATA3_26560356_Chip-Seq_TH2_Human1.83936204
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79734913
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.77344342
30UTX_26944678_Chip-Seq_JUKART_Human1.75717402
31GATA3_27048872_Chip-Seq_THYMUS_Human1.73211052
32SPI1_23127762_ChIP-Seq_K562_Human1.72505175
33MYC_22102868_ChIP-Seq_BL_Human1.71003516
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.69730658
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57355166
36MAF_26560356_Chip-Seq_TH2_Human1.56820374
37SCL_19346495_ChIP-Seq_HPC-7_Human1.46779222
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38654932
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37656879
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36217733
41VDR_24763502_ChIP-Seq_THP-1_Human1.33405218
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32959134
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31454177
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28721029
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23848668
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22942112
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22721172
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21264315
49BCL6_27268052_Chip-Seq_Bcells_Human1.19928331
50ZNF274_21170338_ChIP-Seq_K562_Hela1.19056506
51DROSHA_22980978_ChIP-Seq_HELA_Human1.18977023
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17565842
53CIITA_25753668_ChIP-Seq_RAJI_Human1.17313518
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.17186877
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16444412
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14970318
57VDR_24787735_ChIP-Seq_THP-1_Human1.11255881
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10574678
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07274552
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06074566
61E2F1_20622854_ChIP-Seq_HELA_Human1.05588642
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05124836
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04728304
64BCAT_22108803_ChIP-Seq_LS180_Human1.04264942
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03451358
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02377215
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00362527
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.00030991
69VDR_21846776_ChIP-Seq_THP-1_Human1.00029782
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99517495
71BCOR_27268052_Chip-Seq_Bcells_Human0.98830319
72RAC3_21632823_ChIP-Seq_H3396_Human0.98246823
73GATA1_22025678_ChIP-Seq_K562_Human0.98078047
74P300_27268052_Chip-Seq_Bcells_Human0.97632226
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95729113
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94595047
77GATA3_26560356_Chip-Seq_TH1_Human0.94444232
78OCT4_20526341_ChIP-Seq_ESCs_Human0.93022513
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91154024
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89302899
81TCF7_22412390_ChIP-Seq_EML_Mouse0.89141560
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88317665
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.87873599
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87873599
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87120652
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86720269
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85207067
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84493485
89SPI1_26923725_Chip-Seq_HPCs_Mouse0.84355402
90GATA1_19941826_ChIP-Seq_K562_Human0.83302831
91WDR5_24793694_ChIP-Seq_LNCAP_Human0.82614218
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.81907764
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81262531
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81184864
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.80889689
96STAT1_20625510_ChIP-Seq_HELA_Human0.80733865
97ER_23166858_ChIP-Seq_MCF-7_Human0.79978156
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79809592
99RXR_22108803_ChIP-Seq_LS180_Human0.79560369
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79206810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.16935243
2MP0001835_abnormal_antigen_presentation3.84502076
3MP0005671_abnormal_response_to3.79887131
4MP0001790_abnormal_immune_system3.56613897
5MP0005387_immune_system_phenotype3.56613897
6MP0003724_increased_susceptibility_to3.48468313
7MP0000685_abnormal_immune_system3.40538164
8MP0001800_abnormal_humoral_immune3.19622362
9MP0003436_decreased_susceptibility_to3.01462677
10MP0003763_abnormal_thymus_physiology2.93911540
11MP0002138_abnormal_hepatobiliary_system2.85228910
12MP0005000_abnormal_immune_tolerance2.66701278
13MP0002723_abnormal_immune_serum2.60468376
14MP0001873_stomach_inflammation2.57141683
15MP0002452_abnormal_antigen_presenting2.47927754
16MP0002420_abnormal_adaptive_immunity2.47333745
17MP0001819_abnormal_immune_cell2.44367587
18MP0002419_abnormal_innate_immunity2.27268751
19MP0005025_abnormal_response_to2.25772547
20MP0003303_peritoneal_inflammation2.24028887
21MP0000465_gastrointestinal_hemorrhage2.23009783
22MP0006072_abnormal_retinal_apoptosis2.08292895
23MP0002398_abnormal_bone_marrow2.02657842
24MP0003646_muscle_fatigue2.00136040
25MP0000716_abnormal_immune_system1.96062297
26MP0003172_abnormal_lysosome_physiology1.96045334
27MP0002148_abnormal_hypersensitivity_rea1.95494366
28MP0000689_abnormal_spleen_morphology1.90038189
29MP0009785_altered_susceptibility_to1.86886334
30MP0002722_abnormal_immune_system1.75608179
31MP0000703_abnormal_thymus_morphology1.75398174
32MP0002332_abnormal_exercise_endurance1.68037718
33MP0003866_abnormal_defecation1.67687698
34MP0003011_delayed_dark_adaptation1.66598350
35MP0005075_abnormal_melanosome_morpholog1.65629464
36MP0002429_abnormal_blood_cell1.53318039
37MP0004947_skin_inflammation1.52509346
38MP0002405_respiratory_system_inflammati1.51144038
39MP0010155_abnormal_intestine_physiology1.50548405
40MP0002396_abnormal_hematopoietic_system1.49149000
41MP0008872_abnormal_physiological_respon1.47786843
42MP0009333_abnormal_splenocyte_physiolog1.46887010
43MP0001986_abnormal_taste_sensitivity1.39216040
44MP0001845_abnormal_inflammatory_respons1.36254505
45MP0004381_abnormal_hair_follicle1.29175798
46MP0001533_abnormal_skeleton_physiology1.26162482
47MP0005464_abnormal_platelet_physiology1.24786369
48MP0002009_preneoplasia1.22134461
49MP0003638_abnormal_response/metabolism_1.21344708
50MP0005253_abnormal_eye_physiology1.19291640
51MP0004147_increased_porphyrin_level1.17152035
52MP0003806_abnormal_nucleotide_metabolis1.14348455
53MP0003252_abnormal_bile_duct1.13919390
54MP0009764_decreased_sensitivity_to1.12980995
55MP0002877_abnormal_melanocyte_morpholog1.09642031
56MP0006082_CNS_inflammation1.07129827
57MP0008469_abnormal_protein_level1.06702328
58MP0002933_joint_inflammation1.06142544
59MP0002876_abnormal_thyroid_physiology1.03655973
60MP0003300_gastrointestinal_ulcer1.03573026
61MP0009278_abnormal_bone_marrow1.01727410
62MP0003828_pulmonary_edema0.99152813
63MP0003183_abnormal_peptide_metabolism0.95471865
64MP0001851_eye_inflammation0.91484195
65MP0004130_abnormal_muscle_cell0.91103783
66MP0005310_abnormal_salivary_gland0.89304002
67MP0000858_altered_metastatic_potential0.83335055
68MP0002095_abnormal_skin_pigmentation0.82279525
69MP0002693_abnormal_pancreas_physiology0.81242936
70MP0004043_abnormal_pH_regulation0.80902831
71MP0001663_abnormal_digestive_system0.79082999
72MP0008995_early_reproductive_senescence0.78114821
73MP0000569_abnormal_digit_pigmentation0.77540959
74MP0003656_abnormal_erythrocyte_physiolo0.75905905
75MP0002928_abnormal_bile_duct0.74881037
76MP0002254_reproductive_system_inflammat0.74676235
77MP0004510_myositis0.71283730
78MP0000490_abnormal_crypts_of0.70674705
79MP0000678_abnormal_parathyroid_gland0.69398735
80MP0002277_abnormal_respiratory_mucosa0.69173787
81MP0002132_abnormal_respiratory_system0.68718234
82MP0002166_altered_tumor_susceptibility0.68430611
83MP0004808_abnormal_hematopoietic_stem0.64992353
84MP0002019_abnormal_tumor_incidence0.63136515
85MP0005551_abnormal_eye_electrophysiolog0.62751103
86MP0009765_abnormal_xenobiotic_induced0.62153576
87MP0002735_abnormal_chemical_nociception0.60112713
88MP0002998_abnormal_bone_remodeling0.59991858
89MP0003195_calcinosis0.59549616
90MP0005535_abnormal_body_temperature0.58055787
91MP0009763_increased_sensitivity_to0.57866815
92MP0005085_abnormal_gallbladder_physiolo0.57715190
93MP0002733_abnormal_thermal_nociception0.57498369
94MP0004036_abnormal_muscle_relaxation0.56299892
95MP0000681_abnormal_thyroid_gland0.56083256
96MP0000249_abnormal_blood_vessel0.53737749
97MP0008875_abnormal_xenobiotic_pharmacok0.51667569
98MP0005397_hematopoietic_system_phenotyp0.50349028
99MP0001545_abnormal_hematopoietic_system0.50349028
100MP0002136_abnormal_kidney_physiology0.48386947

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.38443690
2Congenital stationary night blindness (HP:0007642)7.17033113
3Chronic sinusitis (HP:0011109)4.71666604
4Recurrent bronchitis (HP:0002837)4.66462783
5Cellulitis (HP:0100658)4.32418052
611 pairs of ribs (HP:0000878)4.30353339
7Progressive external ophthalmoplegia (HP:0000590)4.26620966
8Persistence of primary teeth (HP:0006335)4.16181924
9Meningitis (HP:0001287)4.07536023
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.02398944
11Elevated erythrocyte sedimentation rate (HP:0003565)3.97958484
12Verrucae (HP:0200043)3.89136007
13Papilloma (HP:0012740)3.89136007
14Flared iliac wings (HP:0002869)3.82171923
15Short nail (HP:0001799)3.58056104
16Prostate neoplasm (HP:0100787)3.47029080
17Recurrent bacterial skin infections (HP:0005406)3.30443182
18Abnormality of the prostate (HP:0008775)3.24658620
19Panhypogammaglobulinemia (HP:0003139)3.23807745
20Abnormality of binocular vision (HP:0011514)3.22826218
21Diplopia (HP:0000651)3.22826218
22Stomatitis (HP:0010280)3.19026364
23Recurrent pneumonia (HP:0006532)3.17210967
24Myositis (HP:0100614)3.13597056
25Eczematoid dermatitis (HP:0000976)3.03659945
26Recurrent abscess formation (HP:0002722)2.98990529
27IgG deficiency (HP:0004315)2.92368787
28Gastrointestinal infarctions (HP:0005244)2.92085796
29Recurrent fungal infections (HP:0002841)2.87424524
30Protruding tongue (HP:0010808)2.85666928
31Broad distal phalanx of finger (HP:0009836)2.83679200
32Clumsiness (HP:0002312)2.81357454
33Osteomyelitis (HP:0002754)2.80633164
34Encephalitis (HP:0002383)2.78245100
35T lymphocytopenia (HP:0005403)2.71250168
36Optic neuritis (HP:0100653)2.71133347
37Retrobulbar optic neuritis (HP:0100654)2.71133347
38Recurrent gram-negative bacterial infections (HP:0005420)2.70031939
39Abnormality of T cell number (HP:0011839)2.65562216
40Sepsis (HP:0100806)2.64335702
41Bronchitis (HP:0012387)2.63089615
42Spontaneous hematomas (HP:0007420)2.60796725
43Abnormality of T cells (HP:0002843)2.59913838
44Recurrent lower respiratory tract infections (HP:0002783)2.57454630
45Skin rash (HP:0000988)2.55580915
46Vasculitis (HP:0002633)2.55464996
47Recurrent viral infections (HP:0004429)2.54147783
48Orchitis (HP:0100796)2.50589891
49Chronic obstructive pulmonary disease (HP:0006510)2.50006056
50Obstructive lung disease (HP:0006536)2.50006056
51Bicuspid aortic valve (HP:0001647)2.49779364
52Radial bowing (HP:0002986)2.45544888
53Abnormality of macrophages (HP:0004311)2.39446912
54Recurrent cutaneous fungal infections (HP:0011370)2.36987718
55Chronic mucocutaneous candidiasis (HP:0002728)2.36987718
56Stomach cancer (HP:0012126)2.35927763
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.27711760
58Inflammation of the large intestine (HP:0002037)2.26310596
59Lymphopenia (HP:0001888)2.25451083
60Gastrointestinal stroma tumor (HP:0100723)2.25216658
61Abnormality of T cell physiology (HP:0011840)2.25029069
62Recurrent otitis media (HP:0000403)2.23739013
63IgM deficiency (HP:0002850)2.23159638
64Recurrent skin infections (HP:0001581)2.22500377
65Gingivitis (HP:0000230)2.19451291
66Pustule (HP:0200039)2.17794421
67Prolonged bleeding time (HP:0003010)2.17260425
68Genetic anticipation (HP:0003743)2.08374328
69Abnormality of male internal genitalia (HP:0000022)2.06638928
70Coxa valga (HP:0002673)2.05738241
71Gastrointestinal inflammation (HP:0004386)2.04494826
72Mediastinal lymphadenopathy (HP:0100721)2.02614133
73Glucose intolerance (HP:0000833)2.01579583
74Abnormality of B cell number (HP:0010975)2.01414394
75Hemoptysis (HP:0002105)1.99248570
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93072889
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89985865
78Leukocytosis (HP:0001974)1.89562462
79Hematochezia (HP:0002573)1.89438121
80Proximal tubulopathy (HP:0000114)1.88003276
81Joint swelling (HP:0001386)1.86350410
82Hypochromic anemia (HP:0001931)1.85703812
83Abnormal glucose tolerance (HP:0001952)1.85655973
84Pulmonary infiltrates (HP:0002113)1.85496015
85Hypochromic microcytic anemia (HP:0004840)1.84864665
86Colitis (HP:0002583)1.84125814
87External ophthalmoplegia (HP:0000544)1.83692218
88Delayed CNS myelination (HP:0002188)1.83488803
89Chronic otitis media (HP:0000389)1.82535692
90Supernumerary spleens (HP:0009799)1.81586984
91Keratoconjunctivitis sicca (HP:0001097)1.80750088
92Increased IgE level (HP:0003212)1.80618410
93Annular pancreas (HP:0001734)1.78334891
94Large for gestational age (HP:0001520)1.77623794
95Keratoconjunctivitis (HP:0001096)1.75471830
96Supernumerary bones of the axial skeleton (HP:0009144)1.75351241
97Urticaria (HP:0001025)1.75113499
98Thrombocytosis (HP:0001894)1.73910171
99Abnormal vertebral ossification (HP:0100569)1.73379322
100Cupped ribs (HP:0000887)1.72907024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK15.02986202
2ACVR1B2.88696367
3MAP4K12.72658573
4TIE12.39367608
5SIK32.36796513
6MAP3K132.01509642
7TESK211.1275197
8SIK21.95038055
9TLK11.92001957
10TXK1.91889869
11RIPK41.81290212
12IRAK41.79298975
13ITK1.72319114
14TYK21.70114961
15MAPKAPK31.69220644
16TNK21.53380553
17SYK1.52921534
18TEC1.49917572
19GRK61.35221596
20KIT1.33125278
21ZAK1.30326733
22MARK31.22774669
23SIK11.20031424
24FLT31.17455914
25MAP3K141.16574091
26BTK1.09047581
27MARK21.05424068
28ZAP701.03188495
29FES0.99852750
30JAK30.98571067
31CSF1R0.98177519
32KSR20.97697929
33LCK0.94587821
34IKBKE0.92375707
35HCK0.91649318
36BMPR1B0.90677948
37ICK0.90342827
38MAP3K110.85428145
39TBK10.83085601
40CSK0.81308204
41LYN0.81106714
42ADRBK20.78561461
43BLK0.71740371
44TAOK30.71026453
45CCNB10.67352884
46CAMKK10.66544011
47PRKCQ0.63714029
48STK160.61914094
49MAP2K30.57045322
50BMPR20.54789859
51MAP3K10.53779191
52CAMKK20.53332276
53IKBKB0.53210616
54TRPM70.52182883
55WNK10.52017578
56EIF2AK30.50983371
57IRAK10.50411230
58RAF10.50133321
59JAK10.50099822
60PRPF4B0.48423027
61MST40.45554125
62MAP2K20.44718049
63TGFBR10.42111117
64TAOK10.40693909
65FRK0.40455935
66PRKD20.38502030
67MAP3K20.38229607
68JAK20.37916192
69NLK0.34885095
70KDR0.33080224
71NTRK30.32316425
72PIK3CG0.31426871
73MAPK70.31063778
74HIPK20.29234052
75MAPK120.27920565
76MAP2K10.27918064
77CDK190.27291628
78MAPK110.27159003
79PIM10.26145081
80RET0.25878474
81LRRK20.25684842
82INSRR0.25036536
83FYN0.24964309
84PRKCH0.23713279
85PDK10.21944144
86KSR10.21898013
87MAP3K90.19873516
88PTK2B0.19819053
89CAMK1D0.18744280
90ARAF0.18264554
91MAP3K100.17687685
92CHUK0.17396341
93ERN10.16790786
94CDK40.16732728
95PRKD10.15942529
96INSR0.14845569
97TGFBR20.14540215
98STK100.14434709
99IGF1R0.13985397
100MAPKAPK20.13873543

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.83097225
2Graft-versus-host disease_Homo sapiens_hsa053323.28029357
3Phototransduction_Homo sapiens_hsa047443.25563998
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.83917737
5Allograft rejection_Homo sapiens_hsa053302.79356234
6Autoimmune thyroid disease_Homo sapiens_hsa053202.78489331
7B cell receptor signaling pathway_Homo sapiens_hsa046622.63008322
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35274810
9Antigen processing and presentation_Homo sapiens_hsa046122.30131990
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13273877
11Asthma_Homo sapiens_hsa053102.09805320
12Leishmaniasis_Homo sapiens_hsa051402.09601320
13Type I diabetes mellitus_Homo sapiens_hsa049402.04672496
14Osteoclast differentiation_Homo sapiens_hsa043802.04662060
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82170466
16Staphylococcus aureus infection_Homo sapiens_hsa051501.80155696
17Hematopoietic cell lineage_Homo sapiens_hsa046401.78436049
18T cell receptor signaling pathway_Homo sapiens_hsa046601.68712424
19Linoleic acid metabolism_Homo sapiens_hsa005911.64696132
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.63502081
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59046468
22Acute myeloid leukemia_Homo sapiens_hsa052211.52060172
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49895297
24Tuberculosis_Homo sapiens_hsa051521.40945193
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34639846
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33946231
27Chemokine signaling pathway_Homo sapiens_hsa040621.33453932
28Other glycan degradation_Homo sapiens_hsa005111.33083165
29Selenocompound metabolism_Homo sapiens_hsa004501.28501099
30Viral myocarditis_Homo sapiens_hsa054161.21366027
31Measles_Homo sapiens_hsa051621.20754459
32Nitrogen metabolism_Homo sapiens_hsa009101.10455162
33Influenza A_Homo sapiens_hsa051641.09368025
34Rheumatoid arthritis_Homo sapiens_hsa053231.08605689
35Toxoplasmosis_Homo sapiens_hsa051451.07977320
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01809865
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00755994
38Herpes simplex infection_Homo sapiens_hsa051681.00679109
39VEGF signaling pathway_Homo sapiens_hsa043701.00289549
40Ether lipid metabolism_Homo sapiens_hsa005650.99580340
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.95706054
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93054349
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92093055
44Non-small cell lung cancer_Homo sapiens_hsa052230.90390277
45ABC transporters_Homo sapiens_hsa020100.88494601
46Malaria_Homo sapiens_hsa051440.88214169
47Platelet activation_Homo sapiens_hsa046110.84411268
48Dorso-ventral axis formation_Homo sapiens_hsa043200.83775529
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83361372
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82830177
51Regulation of autophagy_Homo sapiens_hsa041400.80608731
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78881373
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77603043
54TNF signaling pathway_Homo sapiens_hsa046680.73900238
55Ovarian steroidogenesis_Homo sapiens_hsa049130.73700307
56Hepatitis C_Homo sapiens_hsa051600.70380761
57Legionellosis_Homo sapiens_hsa051340.69081088
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67858014
59African trypanosomiasis_Homo sapiens_hsa051430.66577071
60Inositol phosphate metabolism_Homo sapiens_hsa005620.66036855
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64663713
62Arachidonic acid metabolism_Homo sapiens_hsa005900.63009401
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60584159
64Morphine addiction_Homo sapiens_hsa050320.59504397
65HTLV-I infection_Homo sapiens_hsa051660.59234622
66Hepatitis B_Homo sapiens_hsa051610.55523083
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.55219725
68Serotonergic synapse_Homo sapiens_hsa047260.52756863
69Cholinergic synapse_Homo sapiens_hsa047250.48170962
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.46155800
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46123528
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.45895267
73Renal cell carcinoma_Homo sapiens_hsa052110.45574469
74Olfactory transduction_Homo sapiens_hsa047400.44818885
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44301087
76Phagosome_Homo sapiens_hsa041450.43935199
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.43453425
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43185628
79Pancreatic cancer_Homo sapiens_hsa052120.42828823
80FoxO signaling pathway_Homo sapiens_hsa040680.41510950
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40597874
82Choline metabolism in cancer_Homo sapiens_hsa052310.40404708
83Epstein-Barr virus infection_Homo sapiens_hsa051690.39889683
84Oxytocin signaling pathway_Homo sapiens_hsa049210.39351996
85Chronic myeloid leukemia_Homo sapiens_hsa052200.39030229
86Endocytosis_Homo sapiens_hsa041440.38656192
87Lysosome_Homo sapiens_hsa041420.37155131
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.37146290
89MAPK signaling pathway_Homo sapiens_hsa040100.37058885
90Calcium signaling pathway_Homo sapiens_hsa040200.36376921
91Glycerolipid metabolism_Homo sapiens_hsa005610.36256058
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.35543524
93Ras signaling pathway_Homo sapiens_hsa040140.34747807
94Gastric acid secretion_Homo sapiens_hsa049710.33735732
95Prolactin signaling pathway_Homo sapiens_hsa049170.33484191
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32051620
97Apoptosis_Homo sapiens_hsa042100.31606580
98Type II diabetes mellitus_Homo sapiens_hsa049300.30203795
99Notch signaling pathway_Homo sapiens_hsa043300.28760592
100Fat digestion and absorption_Homo sapiens_hsa049750.28096433

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »