CEBPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.46263945
2L-phenylalanine catabolic process (GO:0006559)6.46263945
3L-phenylalanine metabolic process (GO:0006558)6.19860581
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.19860581
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.88919800
6alpha-linolenic acid metabolic process (GO:0036109)5.71663858
7aromatic amino acid family catabolic process (GO:0009074)5.71124524
8complement activation, alternative pathway (GO:0006957)5.40680554
9sulfur amino acid catabolic process (GO:0000098)5.18240419
10bile acid biosynthetic process (GO:0006699)5.09974119
11tryptophan catabolic process (GO:0006569)5.05265330
12indole-containing compound catabolic process (GO:0042436)5.05265330
13indolalkylamine catabolic process (GO:0046218)5.05265330
14protein carboxylation (GO:0018214)5.04621521
15peptidyl-glutamic acid carboxylation (GO:0017187)5.04621521
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.01007463
17regulation of triglyceride catabolic process (GO:0010896)5.00175919
18kynurenine metabolic process (GO:0070189)4.95505462
19glyoxylate metabolic process (GO:0046487)4.90838483
20regulation of protein activation cascade (GO:2000257)4.87648633
21cysteine metabolic process (GO:0006534)4.82911875
22negative regulation of fibrinolysis (GO:0051918)4.82157367
23high-density lipoprotein particle remodeling (GO:0034375)4.79379731
24tryptophan metabolic process (GO:0006568)4.76366374
25plasma lipoprotein particle clearance (GO:0034381)4.68663940
26regulation of complement activation (GO:0030449)4.63453891
27* urea cycle (GO:0000050)4.62591215
28* urea metabolic process (GO:0019627)4.62591215
29regulation of fibrinolysis (GO:0051917)4.56517648
30acylglycerol homeostasis (GO:0055090)4.50764080
31triglyceride homeostasis (GO:0070328)4.50764080
32bile acid metabolic process (GO:0008206)4.46921680
33serine family amino acid catabolic process (GO:0009071)4.40011661
34amino-acid betaine metabolic process (GO:0006577)4.39529247
35reverse cholesterol transport (GO:0043691)4.33107203
36protein-lipid complex remodeling (GO:0034368)4.30161035
37macromolecular complex remodeling (GO:0034367)4.30161035
38plasma lipoprotein particle remodeling (GO:0034369)4.30161035
39phospholipid efflux (GO:0033700)4.26421738
40lysine metabolic process (GO:0006553)4.26141391
41lysine catabolic process (GO:0006554)4.26141391
42regulation of cholesterol esterification (GO:0010872)4.23865605
43* nitrogen cycle metabolic process (GO:0071941)4.22667461
44homocysteine metabolic process (GO:0050667)4.22279925
45positive regulation of fatty acid beta-oxidation (GO:0032000)4.19779765
46diacylglycerol metabolic process (GO:0046339)4.18860035
47positive regulation of lipid catabolic process (GO:0050996)4.16841083
48tyrosine metabolic process (GO:0006570)4.13168310
49low-density lipoprotein particle clearance (GO:0034383)4.12278411
50aromatic amino acid family metabolic process (GO:0009072)4.09292594
51alpha-amino acid catabolic process (GO:1901606)4.03480310
52valine metabolic process (GO:0006573)4.02059397
53fatty acid beta-oxidation (GO:0006635)3.99001771
54negative regulation of granulocyte differentiation (GO:0030853)3.95134241
55ethanol oxidation (GO:0006069)3.93084454
56fatty acid oxidation (GO:0019395)3.88613679
57negative regulation of cholesterol transport (GO:0032375)3.86970174
58negative regulation of sterol transport (GO:0032372)3.86970174
59acetyl-CoA metabolic process (GO:0006084)3.86953086
60bile acid and bile salt transport (GO:0015721)3.83484881
61negative regulation of lipase activity (GO:0060192)3.82111913
62cholesterol efflux (GO:0033344)3.82078003
63phospholipid homeostasis (GO:0055091)3.81283937
64cellular ketone body metabolic process (GO:0046950)3.81234169
65regulation of cholesterol storage (GO:0010885)3.81191366
66lipid oxidation (GO:0034440)3.81151050
67cellular amino acid catabolic process (GO:0009063)3.79439042
68fatty acid catabolic process (GO:0009062)3.76425997
69regulation of sequestering of triglyceride (GO:0010889)3.75948950
70coenzyme catabolic process (GO:0009109)3.75016944
71complement activation (GO:0006956)3.74204113
72plasma lipoprotein particle assembly (GO:0034377)3.67617596
73NADH metabolic process (GO:0006734)3.65663812
74monocarboxylic acid catabolic process (GO:0072329)3.65620967
75negative regulation of erythrocyte differentiation (GO:0045647)3.63384043
76positive regulation of fatty acid oxidation (GO:0046321)3.62974526
77complement activation, classical pathway (GO:0006958)3.62188423
78imidazole-containing compound metabolic process (GO:0052803)3.61329033
79glycine metabolic process (GO:0006544)3.59557861
80positive regulation of triglyceride lipase activity (GO:0061365)3.59540751
81positive regulation of lipoprotein lipase activity (GO:0051006)3.59540751
82short-chain fatty acid metabolic process (GO:0046459)3.58650079
83fibrinolysis (GO:0042730)3.58533233
84cellular modified amino acid catabolic process (GO:0042219)3.57025569
85organic acid catabolic process (GO:0016054)3.56934312
86carboxylic acid catabolic process (GO:0046395)3.56934312
87cholesterol homeostasis (GO:0042632)3.56931582
88triglyceride catabolic process (GO:0019433)3.55349006
89neutral lipid catabolic process (GO:0046461)3.55116491
90acylglycerol catabolic process (GO:0046464)3.55116491
91cellular glucuronidation (GO:0052695)3.53802165
92positive regulation of cholesterol efflux (GO:0010875)3.53649027
93low-density lipoprotein particle remodeling (GO:0034374)3.53265751
94biotin metabolic process (GO:0006768)3.52646184
95regulation of fatty acid beta-oxidation (GO:0031998)3.52634620
96regulation of cholesterol homeostasis (GO:2000188)3.52471002
97fatty acid transmembrane transport (GO:1902001)3.52011668
98sterol homeostasis (GO:0055092)3.51466996
99protein activation cascade (GO:0072376)3.51203558
100indolalkylamine metabolic process (GO:0006586)3.49925358
101serine family amino acid metabolic process (GO:0009069)3.49465860
1022-oxoglutarate metabolic process (GO:0006103)3.49434832
103glutamate metabolic process (GO:0006536)3.47751529
104carnitine metabolic process (GO:0009437)3.47597489
105cytolysis (GO:0019835)3.47374329
106response to peptidoglycan (GO:0032494)3.47242509
107positive regulation of triglyceride metabolic process (GO:0090208)3.45222340
108angiotensin maturation (GO:0002003)3.45202197
109fatty acid homeostasis (GO:0055089)3.44383070
110neutrophil activation involved in immune response (GO:0002283)3.25942777
111detection of other organism (GO:0098543)3.21956364
112mannose metabolic process (GO:0006013)3.16950634
113pinocytosis (GO:0006907)3.12756678
114positive regulation of cholesterol transport (GO:0032376)3.12347393
115positive regulation of sterol transport (GO:0032373)3.12347393
116lipid storage (GO:0019915)3.10762098
117positive regulation of gamma-delta T cell activation (GO:0046645)3.10760335
118detection of bacterium (GO:0016045)3.08765274
119regulation of sterol transport (GO:0032371)3.08083169
120regulation of cholesterol transport (GO:0032374)3.08083169
121glycosphingolipid catabolic process (GO:0046479)3.07835625
122regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07179578
123glycerolipid catabolic process (GO:0046503)3.06990399
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.05325676
125plasma lipoprotein particle organization (GO:0071827)3.04084395
126ethanol metabolic process (GO:0006067)2.97273838
127protein-lipid complex subunit organization (GO:0071825)2.95668079
128triglyceride metabolic process (GO:0006641)2.95248944
129very-low-density lipoprotein particle assembly (GO:0034379)2.94979963
130cellular extravasation (GO:0045123)2.94168485
131protein-lipid complex assembly (GO:0065005)2.90405199
132detection of external biotic stimulus (GO:0098581)2.85381678
133positive regulation of cellular amide metabolic process (GO:0034250)2.84960754
134regulation of leukocyte degranulation (GO:0043300)2.83996530
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83955455
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.83955455
137modulation by symbiont of host immune response (GO:0052553)2.83955455
138positive regulation by symbiont of host defense response (GO:0052509)2.83955455
139modulation by symbiont of host defense response (GO:0052031)2.83955455
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83955455
141negative regulation of phagocytosis (GO:0050765)2.83695672
142regulation of mast cell degranulation (GO:0043304)2.83165043
143response to hydroperoxide (GO:0033194)2.82896890
144acylglycerol metabolic process (GO:0006639)2.82707563
145positive regulation of lipid storage (GO:0010884)2.80851349
146neutral lipid metabolic process (GO:0006638)2.78101538
147glycolipid catabolic process (GO:0019377)2.77550828
148transcytosis (GO:0045056)2.77481789
149oxaloacetate metabolic process (GO:0006107)2.74213253
150lipoprotein transport (GO:0042953)2.72371264
151regulation of lipoprotein particle clearance (GO:0010984)2.71215370
152barbed-end actin filament capping (GO:0051016)2.63967778
153macrophage activation involved in immune response (GO:0002281)2.63737570
154detection of molecule of bacterial origin (GO:0032490)2.63535528
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62261345
156regulation of triglyceride metabolic process (GO:0090207)2.61167945
157oligosaccharide catabolic process (GO:0009313)2.61151388
158regulation of phagocytosis (GO:0050764)2.59572648
159triglyceride biosynthetic process (GO:0019432)2.58908112
160epoxygenase P450 pathway (GO:0019373)2.56759083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.43823669
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.27263921
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.47142232
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.89647494
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.62859067
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.61874301
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.21408948
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66820079
9* VDR_21846776_ChIP-Seq_THP-1_Human3.57274222
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.25348583
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.16211665
12* VDR_24763502_ChIP-Seq_THP-1_Human2.77229306
13* CLOCK_20551151_ChIP-Seq_293T_Human2.39964387
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18095943
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2991115
16GATA1_22025678_ChIP-Seq_K562_Human1.93760005
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88826022
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88066095
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79377989
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75698472
21MYC_22102868_ChIP-Seq_BL_Human1.71318327
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.68591421
23* SCL_19346495_ChIP-Seq_HPC-7_Human1.68185770
24RUNX1_22412390_ChIP-Seq_EML_Mouse1.64635704
25* TCF7_22412390_ChIP-Seq_EML_Mouse1.63591903
26SPI1_23547873_ChIP-Seq_NB4_Human1.60417885
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60208233
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59476054
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53466429
30SPI1_23127762_ChIP-Seq_K562_Human1.51862820
31KDM2B_26808549_Chip-Seq_DND41_Human1.51725325
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.50086035
33GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39494632
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38601060
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37727848
36MAF_26560356_Chip-Seq_TH1_Human1.37137163
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36634641
38UTX_26944678_Chip-Seq_JUKART_Human1.32834048
39* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32373714
40PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29360479
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29205364
42P68_20966046_ChIP-Seq_HELA_Human1.29099411
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27098731
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26817950
45BCL6_27268052_Chip-Seq_Bcells_Human1.25565778
46PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24523543
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24398891
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24134675
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22433000
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21367349
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20503910
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20413516
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18215035
54MAF_26560356_Chip-Seq_TH2_Human1.17650818
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.17516628
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.15597778
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13786402
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12900923
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12640221
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.11218280
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09307479
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08938358
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08617307
64ZNF263_19887448_ChIP-Seq_K562_Human1.07084628
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.06798262
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06416583
67KDM2B_26808549_Chip-Seq_K562_Human1.04613375
68* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03631676
69* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03185611
70SMC4_20622854_ChIP-Seq_HELA_Human1.03073991
71RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03043244
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02489700
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01803927
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01762152
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00598416
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99055102
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97789237
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96842845
79* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96835762
80SPI1_20517297_ChIP-Seq_HL60_Human0.96302816
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95562042
82IRF8_27001747_Chip-Seq_BMDM_Mouse0.94979241
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94221716
84LXR_22292898_ChIP-Seq_THP-1_Human0.93495653
85TP63_17297297_ChIP-ChIP_HaCaT_Human0.93374976
86HTT_18923047_ChIP-ChIP_STHdh_Human0.92272437
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92205913
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91472115
89* GATA4_25053715_ChIP-Seq_YYC3_Human0.91080452
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90198623
91* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90187518
92* ESR2_21235772_ChIP-Seq_MCF-7_Human0.87328542
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86860421
94* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86851986
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86436988
96PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85762169
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84708364
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.83874213
99IRF8_21731497_ChIP-ChIP_J774_Mouse0.82161048
100MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81624034
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76023341
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.75267338
103GATA1_19941826_ChIP-Seq_K562_Human0.74713500
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70926333
105GATA2_19941826_ChIP-Seq_K562_Human0.70875179
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70150587
107* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69044448
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67542722
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65455503
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.65187512
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64384203
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64233266
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.64204032
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64051927
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64051927
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63967001
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62634321
118RACK7_27058665_Chip-Seq_MCF-7_Human0.62422055
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62391050
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61785253
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.61619783
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60691345
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.60379455
124* CEBPB_22108803_ChIP-Seq_LS180_Human0.60350671
125EGR1_19032775_ChIP-ChIP_M12_Human0.59981194
126* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.59651638
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59131330
128SOX2_20726797_ChIP-Seq_SW620_Human0.59063759
129* CDX2_20551321_ChIP-Seq_CACO-2_Human0.58163754
130* RARA_24833708_ChIP-Seq_LIVER_Mouse0.57856498
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.56513128
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.56355240
133* TBX20_22080862_ChIP-Seq_HEART_Mouse0.56103478
134* TBX20_22328084_ChIP-Seq_HEART_Mouse0.56103478
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.55533217
136BP1_19119308_ChIP-ChIP_Hs578T_Human0.55310127
137* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54716930
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.54310419
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.53836238
140GATA6_25053715_ChIP-Seq_YYC3_Human0.53260240
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52927713
142RARB_24833708_ChIP-Seq_LIVER_Mouse0.52902751
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.52423080
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51663236
145VDR_24787735_ChIP-Seq_THP-1_Human0.51577134
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.51291715
147BCOR_27268052_Chip-Seq_Bcells_Human0.50581573
148TRIM28_21343339_ChIP-Seq_HEK293_Human0.50367764
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.49471924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.11084745
2MP0005360_urolithiasis6.45478245
3MP0005365_abnormal_bile_salt5.55373348
4MP0005085_abnormal_gallbladder_physiolo5.41885089
5MP0008875_abnormal_xenobiotic_pharmacok4.22131090
6* MP0010329_abnormal_lipoprotein_level3.73095207
7MP0009840_abnormal_foam_cell3.44160926
8MP0003191_abnormal_cellular_cholesterol3.42040488
9MP0003252_abnormal_bile_duct3.38945461
10MP0003806_abnormal_nucleotide_metabolis3.23335869
11MP0005670_abnormal_white_adipose2.75509089
12MP0005083_abnormal_biliary_tract2.62648320
13* MP0005332_abnormal_amino_acid2.36918066
14* MP0002118_abnormal_lipid_homeostasis2.34810253
15* MP0000609_abnormal_liver_physiology2.27532521
16MP0001666_abnormal_nutrient_absorption2.26487571
17MP0003172_abnormal_lysosome_physiology2.24357898
18MP0003195_calcinosis2.01339718
19MP0003705_abnormal_hypodermis_morpholog1.90255388
20MP0003828_pulmonary_edema1.88342623
21MP0004019_abnormal_vitamin_homeostasis1.86415492
22* MP0005025_abnormal_response_to1.77791128
23* MP0005319_abnormal_enzyme/_coenzyme1.73102531
24MP0001835_abnormal_antigen_presentation1.67688395
25MP0005584_abnormal_enzyme/coenzyme_acti1.62532922
26MP0009785_altered_susceptibility_to1.56839822
27MP0001764_abnormal_homeostasis1.55883624
28MP0002138_abnormal_hepatobiliary_system1.55797701
29* MP0004130_abnormal_muscle_cell1.51533172
30* MP0005666_abnormal_adipose_tissue1.47411941
31MP0002254_reproductive_system_inflammat1.46972901
32MP0003186_abnormal_redox_activity1.43913060
33MP0002148_abnormal_hypersensitivity_rea1.39009965
34MP0009278_abnormal_bone_marrow1.36830936
35MP0000685_abnormal_immune_system1.36186407
36* MP0002971_abnormal_brown_adipose1.35798361
37MP0000858_altered_metastatic_potential1.35581339
38MP0003868_abnormal_feces_composition1.35408073
39MP0009643_abnormal_urine_homeostasis1.31138845
40MP0005000_abnormal_immune_tolerance1.30785280
41MP0008260_abnormal_autophagy1.30432713
42MP0003724_increased_susceptibility_to1.25490172
43MP0001790_abnormal_immune_system1.24500351
44MP0005387_immune_system_phenotype1.24500351
45MP0005451_abnormal_body_composition1.22703050
46MP0002998_abnormal_bone_remodeling1.21319020
47* MP0005334_abnormal_fat_pad1.19054352
48MP0003011_delayed_dark_adaptation1.18736393
49* MP0000598_abnormal_liver_morphology1.18375525
50MP0003690_abnormal_glial_cell1.17745742
51MP0002723_abnormal_immune_serum1.15707101
52MP0002420_abnormal_adaptive_immunity1.15682716
53MP0002452_abnormal_antigen_presenting1.15602481
54MP0008438_abnormal_cutaneous_collagen1.15489638
55MP0001819_abnormal_immune_cell1.15392994
56MP0005647_abnormal_sex_gland1.14519264
57MP0005058_abnormal_lysosome_morphology1.13912300
58MP0010155_abnormal_intestine_physiology1.13595480
59MP0001800_abnormal_humoral_immune1.13237819
60MP0000604_amyloidosis1.13097743
61MP0009763_increased_sensitivity_to1.11407548
62MP0005671_abnormal_response_to1.10017772
63* MP0001545_abnormal_hematopoietic_system1.07767010
64* MP0005397_hematopoietic_system_phenotyp1.07767010
65MP0002876_abnormal_thyroid_physiology1.07310503
66MP0003656_abnormal_erythrocyte_physiolo1.07203252
67MP0009764_decreased_sensitivity_to1.05189459
68MP0009333_abnormal_splenocyte_physiolog1.05110223
69MP0005535_abnormal_body_temperature1.04214081
70* MP0008469_abnormal_protein_level1.02847150
71MP0001851_eye_inflammation1.00643929
72MP0001661_extended_life_span0.99781159
73MP0009379_abnormal_foot_pigmentation0.99129043
74MP0003436_decreased_susceptibility_to0.96295250
75MP0002405_respiratory_system_inflammati0.95427365
76MP0000003_abnormal_adipose_tissue0.94453248
77MP0009697_abnormal_copulation0.94267656
78MP0003183_abnormal_peptide_metabolism0.92913222
79MP0010368_abnormal_lymphatic_system0.92471503
80MP0002796_impaired_skin_barrier0.91977536
81MP0005409_darkened_coat_color0.91520251
82* MP0009115_abnormal_fat_cell0.91495633
83* MP0005375_adipose_tissue_phenotype0.90989684
84* MP0002078_abnormal_glucose_homeostasis0.90111414
85MP0000465_gastrointestinal_hemorrhage0.89617539
86MP0005275_abnormal_skin_tensile0.88854787
87MP0005464_abnormal_platelet_physiology0.87207554
88* MP0009642_abnormal_blood_homeostasis0.86945059
89MP0002396_abnormal_hematopoietic_system0.85035128
90MP0005076_abnormal_cell_differentiation0.84715686
91MP0002132_abnormal_respiratory_system0.83153053
92MP0006036_abnormal_mitochondrial_physio0.82247950
93MP0003075_altered_response_to0.78079089
94* MP0002970_abnormal_white_adipose0.76875007
95MP0001756_abnormal_urination0.76626019
96* MP0004185_abnormal_adipocyte_glucose0.75168716
97* MP0005448_abnormal_energy_balance0.74124833
98MP0005376_homeostasis/metabolism_phenot0.73582841
99MP0006082_CNS_inflammation0.73151554
100MP0002060_abnormal_skin_morphology0.72064756
101MP0005636_abnormal_mineral_homeostasis0.69468415
102MP0002837_dystrophic_cardiac_calcinosis0.68513405
103MP0009765_abnormal_xenobiotic_induced0.67265532
104MP0001853_heart_inflammation0.64871774
105MP0001881_abnormal_mammary_gland0.61948185
106MP0000249_abnormal_blood_vessel0.60344243
107MP0002136_abnormal_kidney_physiology0.60272429
108MP0003300_gastrointestinal_ulcer0.57562600
109MP0005164_abnormal_response_to0.56890442
110MP0005220_abnormal_exocrine_pancreas0.56632347
111MP0002419_abnormal_innate_immunity0.55802528
112MP0001533_abnormal_skeleton_physiology0.55355956
113MP0003959_abnormal_lean_body0.51738439
114MP0010234_abnormal_vibrissa_follicle0.51086894
115MP0000343_altered_response_to0.51000799
116MP0005166_decreased_susceptibility_to0.50338815
117MP0009053_abnormal_anal_canal0.50337231
118MP0005084_abnormal_gallbladder_morpholo0.50050080
119MP0004883_abnormal_blood_vessel0.49787511
120MP0003303_peritoneal_inflammation0.49476178
121MP0003638_abnormal_response/metabolism_0.48941688
122* MP0001845_abnormal_inflammatory_respons0.48659317
123MP0005167_abnormal_blood-brain_barrier0.48562081
124MP0005266_abnormal_metabolism0.48553083
125MP0003329_amyloid_beta_deposits0.48111509
126MP0005408_hypopigmentation0.47230487
127MP0000639_abnormal_adrenal_gland0.46930640
128MP0002168_other_aberrant_phenotype0.46799285
129MP0002166_altered_tumor_susceptibility0.46066109
130MP0001243_abnormal_dermal_layer0.45977848
131* MP0003953_abnormal_hormone_level0.44839504
132MP0004947_skin_inflammation0.44639454
133MP0000579_abnormal_nail_morphology0.44426682
134MP0005023_abnormal_wound_healing0.43704845

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.52562887
2Complement deficiency (HP:0004431)6.29385166
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.06943711
4Intrahepatic cholestasis (HP:0001406)5.99287677
5Xanthomatosis (HP:0000991)5.88425325
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.51350171
7Prolonged partial thromboplastin time (HP:0003645)5.39930480
8Hyperlipoproteinemia (HP:0010980)5.28446218
9Hypobetalipoproteinemia (HP:0003563)5.15279445
10Abnormality of complement system (HP:0005339)4.69575574
11Hyperammonemia (HP:0001987)4.44051769
12Hyperglycinuria (HP:0003108)4.40813717
13Epidermoid cyst (HP:0200040)4.36346243
14Joint hemorrhage (HP:0005261)4.36306070
15Hypolipoproteinemia (HP:0010981)4.35164952
16Hypoalphalipoproteinemia (HP:0003233)4.26339250
17Systemic lupus erythematosus (HP:0002725)4.21064159
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16855397
19Hyperglycinemia (HP:0002154)4.13793045
20Abnormality of serine family amino acid metabolism (HP:0010894)4.12819183
21Abnormality of glycine metabolism (HP:0010895)4.12819183
22Ketosis (HP:0001946)4.10843084
23Eczematoid dermatitis (HP:0000976)3.99007694
24Abnormality of the common coagulation pathway (HP:0010990)3.96443943
25Hypoglycemic coma (HP:0001325)3.94127416
26Abnormality of liposaccharide metabolism (HP:0010968)3.93335333
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.93335333
28Abnormality of glycolipid metabolism (HP:0010969)3.93335333
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.87324022
30Vacuolated lymphocytes (HP:0001922)3.81011372
31Recurrent abscess formation (HP:0002722)3.72152252
32Abnormality of fatty-acid metabolism (HP:0004359)3.66818078
33Hypercholesterolemia (HP:0003124)3.58969960
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57947978
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.51231846
36Increased cerebral lipofuscin (HP:0011813)3.49269317
37Dysostosis multiplex (HP:0000943)3.48534975
38Myocardial infarction (HP:0001658)3.45823397
39Recurrent bacterial skin infections (HP:0005406)3.45807710
40Abnormality of macrophages (HP:0004311)3.41484555
41Abnormality of aspartate family amino acid metabolism (HP:0010899)3.37664769
42Fat malabsorption (HP:0002630)3.37612477
43Abnormality of methionine metabolism (HP:0010901)3.34473862
44Glomerulonephritis (HP:0000099)3.30175489
45Abnormality of the intrinsic pathway (HP:0010989)3.28581084
46Increased neuronal autofluorescent lipopigment (HP:0002074)3.07375025
47Ketoacidosis (HP:0001993)2.98549816
48Purpura (HP:0000979)2.98206294
49Abnormality of pyrimidine metabolism (HP:0004353)2.95546264
50Recurrent gram-negative bacterial infections (HP:0005420)2.88666431
51Conjugated hyperbilirubinemia (HP:0002908)2.80660691
52Skin nodule (HP:0200036)2.77325905
53Abnormality of nucleobase metabolism (HP:0010932)2.75708948
54Dicarboxylic aciduria (HP:0003215)2.75678386
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75678386
56Abnormality of serum amino acid levels (HP:0003112)2.73797254
57Amyloidosis (HP:0011034)2.71210233
58Hypertriglyceridemia (HP:0002155)2.70902901
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70692259
60Abnormality of polysaccharide metabolism (HP:0011012)2.70692259
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70692259
62Hyperbilirubinemia (HP:0002904)2.70553230
63Urinary glycosaminoglycan excretion (HP:0003541)2.68231547
64Mucopolysacchariduria (HP:0008155)2.68231547
65Delayed CNS myelination (HP:0002188)2.66457939
66Abnormality of purine metabolism (HP:0004352)2.65790290
67Colitis (HP:0002583)2.61263042
68Gingivitis (HP:0000230)2.61223689
69Hepatocellular carcinoma (HP:0001402)2.60500215
70Increased IgE level (HP:0003212)2.58582818
71Myositis (HP:0100614)2.57946493
72Steatorrhea (HP:0002570)2.54652134
73Hepatosplenomegaly (HP:0001433)2.54296894
74Obstructive lung disease (HP:0006536)2.52797113
75Chronic obstructive pulmonary disease (HP:0006510)2.52797113
76Metabolic acidosis (HP:0001942)2.52521571
77Hemorrhage of the eye (HP:0011885)2.52458926
78Loss of speech (HP:0002371)2.49933901
79Recurrent skin infections (HP:0001581)2.44881872
80Polygenic inheritance (HP:0010982)2.44163681
81Mediastinal lymphadenopathy (HP:0100721)2.41756804
82Nephritis (HP:0000123)2.38947488
83Hydroxyprolinuria (HP:0003080)2.38471208
84Abnormality of proline metabolism (HP:0010907)2.38471208
85Increased serum ferritin (HP:0003281)2.36912955
86Pancreatitis (HP:0001733)2.34454004
87Lethargy (HP:0001254)2.29854698
88Spontaneous abortion (HP:0005268)2.29624132
89Thoracic kyphosis (HP:0002942)2.28794052
90Spastic diplegia (HP:0001264)2.27086451
91Esophageal varix (HP:0002040)2.25903163
92Spontaneous hematomas (HP:0007420)2.21092334
93Epistaxis (HP:0000421)2.20068446
94Sensorimotor neuropathy (HP:0007141)2.19651827
95Prolonged bleeding time (HP:0003010)2.18049356
96Vascular calcification (HP:0004934)2.18029195
97Vertebral compression fractures (HP:0002953)2.17917760
98Mitral stenosis (HP:0001718)2.17296092
99Orchitis (HP:0100796)2.17178345
100Hypoglycemic seizures (HP:0002173)2.14970394
101Generalized aminoaciduria (HP:0002909)2.13791291
102Gingival bleeding (HP:0000225)2.13516571
103Hypochromic microcytic anemia (HP:0004840)2.12481482
104Elevated erythrocyte sedimentation rate (HP:0003565)2.09462436
105Oligomenorrhea (HP:0000876)2.09283327
106Mutism (HP:0002300)2.09243598
107Gout (HP:0001997)2.09022547
108Meningitis (HP:0001287)2.08890267
109Abnormal cartilage morphology (HP:0002763)2.08398643
110Abnormal gallbladder morphology (HP:0012437)2.08103542
111Cholelithiasis (HP:0001081)2.07471652
112Neonatal onset (HP:0003623)2.07210283
113Brushfield spots (HP:0001088)2.06885121
114Inflammation of the large intestine (HP:0002037)2.06494027
115Acanthosis nigricans (HP:0000956)2.06172995
116Menorrhagia (HP:0000132)2.05681343
117Disinhibition (HP:0000734)2.05337006
118Cellulitis (HP:0100658)2.05170135
119Nausea (HP:0002018)2.04740120
120Gastrointestinal inflammation (HP:0004386)2.02311889
121Pathologic fracture (HP:0002756)2.01859520
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01555444
123Cardiovascular calcification (HP:0011915)2.01399963
124Vomiting (HP:0002013)1.98441165
125Abnormality of the periventricular white matter (HP:0002518)1.98226774
126Irritability (HP:0000737)1.97805761
127Acanthocytosis (HP:0001927)1.97295562
128Recurrent fungal infections (HP:0002841)1.97006700
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96014438
130Petechiae (HP:0000967)1.95046595
131Cerebral edema (HP:0002181)1.94296970
132Late onset (HP:0003584)1.93165273
133Pulmonary embolism (HP:0002204)1.93099429
134Malnutrition (HP:0004395)1.91707491
135Retinal atrophy (HP:0001105)1.91655985
136Thrombophlebitis (HP:0004418)1.90364211
137Abnormal gallbladder physiology (HP:0012438)1.89462379
138Cholecystitis (HP:0001082)1.89462379
139Recurrent cutaneous fungal infections (HP:0011370)1.87977261
140Chronic mucocutaneous candidiasis (HP:0002728)1.87977261
141Axonal loss (HP:0003447)1.86020100
142Gastrointestinal infarctions (HP:0005244)1.85926600
143Urticaria (HP:0001025)1.85005432
144Abnormality of iron homeostasis (HP:0011031)1.83848848
145Abnormality of the lumbar spine (HP:0100712)1.79087941
146Opisthotonus (HP:0002179)1.78560651
147Thrombocytosis (HP:0001894)1.78443699
148Pigmentary retinal degeneration (HP:0001146)1.78382903
149Bone pain (HP:0002653)1.77959050
150Growth hormone excess (HP:0000845)1.77912960
151Abnormality of the thoracic spine (HP:0100711)1.77715658
152Upper motor neuron abnormality (HP:0002127)1.76733414
153Elevated hepatic transaminases (HP:0002910)1.76445155
154Abnormality of transition element cation homeostasis (HP:0011030)1.76430373
155Myoglobinuria (HP:0002913)1.75805587
156Hyperglycemia (HP:0003074)1.75475154
157Impaired platelet aggregation (HP:0003540)1.75003967
158Abnormal platelet function (HP:0011869)1.75003967
159Renal cortical cysts (HP:0000803)1.74543017
160Rhabdomyolysis (HP:0003201)1.73823886
161Polycythemia (HP:0001901)1.71259383
162Abnormality of the gallbladder (HP:0005264)1.66060401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.68967076
2ERN14.47388435
3SIK14.38852426
4TRIB33.84729894
5RIPK43.70540490
6CAMK1D3.29818101
7FGFR43.28507863
8PRPF4B2.79620252
9TGFBR22.67239414
10PKN22.50359998
11MST1R2.34095792
12CAMK1G2.15261563
13TAOK32.13872491
14FES2.02288046
15INSRR1.98209718
16TYK21.94722128
17RIPK11.71115158
18FLT31.60794729
19MAP3K131.60314841
20SMG11.58575332
21FGFR21.55118801
22MAP2K31.49524297
23NEK91.49251811
24NME21.47881937
25MAPK151.47594315
26PTK61.44681825
27CSF1R1.41669002
28MAPK111.39604135
29PRKAA21.37085928
30JAK11.35802316
31TBK11.34479482
32ERBB41.33226594
33JAK21.32383182
34EPHB11.31251432
35LATS11.30919814
36PIK3CG1.30662934
37IRAK41.30631731
38IRAK31.29136705
39TNK21.26073748
40MAP2K41.25710458
41FRK1.18406050
42ABL21.12447305
43MAP3K31.09432671
44TAOK11.04575662
45FGFR31.02396478
46DAPK20.98632245
47SYK0.98126290
48CSK0.92160885
49LYN0.88847450
50TESK20.87606171
51MATK0.87072358
52CAMKK20.86774928
53KDR0.84954975
54TIE10.82629558
55DDR20.82561111
56MAP3K100.81914978
57TAOK20.81791734
58MAPK40.81165079
59MET0.80032338
60MAP3K70.78822293
61MAPK120.78051772
62CDK120.77784255
63MAP3K140.76898121
64MAP4K10.75959061
65IKBKB0.75202892
66MARK20.74705311
67KSR20.74599621
68PDPK10.74387837
69BLK0.73515635
70PDK30.73315033
71PDK40.73315033
72ZAP700.72372330
73CDC42BPA0.70963117
74RPS6KL10.69814641
75RPS6KC10.69814641
76MAP3K110.68100626
77GRK60.66870846
78KIT0.66490835
79FGR0.66190402
80TEC0.65379905
81YES10.65073683
82MAP3K60.63422467
83LCK0.63325908
84EPHA30.62430144
85TESK10.61536038
86RPS6KA20.60163656
87PRKAA10.60114606
88PRKACG0.59829628
89PDK20.59220633
90MAP2K10.58813493
91IGF1R0.56179699
92MOS0.55264675
93PRKD20.55255843
94IKBKE0.54915998
95IRAK20.53660584
96PRKCZ0.53646131
97PDK10.53113235
98HIPK20.53020654
99RET0.52265596
100CAMKK10.51572203
101RPS6KA60.51493078
102PDGFRA0.50600912
103PINK10.50415270
104MTOR0.49666680
105ERBB20.48515529
106GRK70.48082522
107SCYL20.48016675
108PIM20.46270361
109LRRK20.46120218
110CAMK10.45075091
111BMX0.44030668
112JAK30.43148704
113PRKG20.41097345
114SGK30.40931159
115CDK90.39192635
116MAPKAPK30.38564834
117PAK40.38292313
118EPHB20.36475601
119STK30.36085472
120DYRK1B0.35987927
121ABL10.35060914
122BTK0.34908490
123PAK20.34605793
124MAPK70.34596514
125ITK0.34393954
126PTK20.34143125
127ICK0.34113768
128EEF2K0.33176704
129EGFR0.33138313
130MAP2K20.31952663
131* GSK3A0.30201701
132MAP2K60.29839214
133MAP3K20.29762212
134HCK0.29415563
135PRKD10.28678048
136MAP3K10.28591475
137PIK3CA0.28431712
138CAMK40.27588972
139STK100.26976806
140IRAK10.26410237

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12399877
2Nitrogen metabolism_Homo sapiens_hsa009103.53247405
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04078183
4Fatty acid degradation_Homo sapiens_hsa000712.79837340
5Arginine biosynthesis_Homo sapiens_hsa002202.78765232
6Complement and coagulation cascades_Homo sapiens_hsa046102.75232432
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74131627
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72053499
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62039271
10Tryptophan metabolism_Homo sapiens_hsa003802.51481392
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50110314
12PPAR signaling pathway_Homo sapiens_hsa033202.46876188
13Propanoate metabolism_Homo sapiens_hsa006402.44154140
14Staphylococcus aureus infection_Homo sapiens_hsa051502.31546863
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27368509
16Fatty acid metabolism_Homo sapiens_hsa012122.22256062
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16960660
18Peroxisome_Homo sapiens_hsa041462.10742269
19Butanoate metabolism_Homo sapiens_hsa006502.02597844
20Caffeine metabolism_Homo sapiens_hsa002321.93011045
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91751670
22beta-Alanine metabolism_Homo sapiens_hsa004101.88832727
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78330303
24Histidine metabolism_Homo sapiens_hsa003401.76810581
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71679816
26Chemical carcinogenesis_Homo sapiens_hsa052041.71428752
27Leishmaniasis_Homo sapiens_hsa051401.62431578
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.59758416
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.57869356
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55057192
31Phenylalanine metabolism_Homo sapiens_hsa003601.52545474
32Pyruvate metabolism_Homo sapiens_hsa006201.50071399
33Retinol metabolism_Homo sapiens_hsa008301.48381656
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40900453
35Fatty acid elongation_Homo sapiens_hsa000621.39124554
36Tyrosine metabolism_Homo sapiens_hsa003501.35904733
37Fat digestion and absorption_Homo sapiens_hsa049751.35597641
38Selenocompound metabolism_Homo sapiens_hsa004501.32750296
39Bile secretion_Homo sapiens_hsa049761.30938579
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28778290
41ABC transporters_Homo sapiens_hsa020101.28263809
42Carbon metabolism_Homo sapiens_hsa012001.28075791
43Starch and sucrose metabolism_Homo sapiens_hsa005001.26380683
44Fatty acid biosynthesis_Homo sapiens_hsa000611.25657377
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19593392
46Sulfur metabolism_Homo sapiens_hsa009201.14607644
47Tuberculosis_Homo sapiens_hsa051521.13240533
48Biosynthesis of amino acids_Homo sapiens_hsa012301.10045229
49Glycerolipid metabolism_Homo sapiens_hsa005611.10022230
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04807343
51Folate biosynthesis_Homo sapiens_hsa007901.00502731
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99702381
53Vitamin B6 metabolism_Homo sapiens_hsa007500.96031397
54B cell receptor signaling pathway_Homo sapiens_hsa046620.95979906
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95009090
56* Acute myeloid leukemia_Homo sapiens_hsa052210.91034545
57Sulfur relay system_Homo sapiens_hsa041220.90675708
58Asthma_Homo sapiens_hsa053100.90473546
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89562589
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89405855
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84625175
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83788600
63Lysine degradation_Homo sapiens_hsa003100.81846665
64Phagosome_Homo sapiens_hsa041450.81465770
65Steroid biosynthesis_Homo sapiens_hsa001000.80083118
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74521969
67Pentose phosphate pathway_Homo sapiens_hsa000300.73598550
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.73514342
69Allograft rejection_Homo sapiens_hsa053300.73226456
70Vitamin digestion and absorption_Homo sapiens_hsa049770.72744245
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72378476
72Arginine and proline metabolism_Homo sapiens_hsa003300.72157015
73Toxoplasmosis_Homo sapiens_hsa051450.69498466
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69329276
75Autoimmune thyroid disease_Homo sapiens_hsa053200.65674168
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65560788
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.64030787
78Graft-versus-host disease_Homo sapiens_hsa053320.60790114
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.59514176
80Glutathione metabolism_Homo sapiens_hsa004800.59446652
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58619729
82Hematopoietic cell lineage_Homo sapiens_hsa046400.58584421
83Antigen processing and presentation_Homo sapiens_hsa046120.51420777
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50955644
85Insulin resistance_Homo sapiens_hsa049310.50649463
86Prion diseases_Homo sapiens_hsa050200.50384662
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50086913
88Influenza A_Homo sapiens_hsa051640.49478886
89Platelet activation_Homo sapiens_hsa046110.46535106
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.41433052
91Rheumatoid arthritis_Homo sapiens_hsa053230.41027297
92Sphingolipid metabolism_Homo sapiens_hsa006000.39497723
93One carbon pool by folate_Homo sapiens_hsa006700.39267770
94Chronic myeloid leukemia_Homo sapiens_hsa052200.38564142
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38377214
96Metabolic pathways_Homo sapiens_hsa011000.38247235
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.36638187
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.36489228
99Systemic lupus erythematosus_Homo sapiens_hsa053220.36357598
100Chemokine signaling pathway_Homo sapiens_hsa040620.35800275
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35580737
102AMPK signaling pathway_Homo sapiens_hsa041520.34898476
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.31556818
104Galactose metabolism_Homo sapiens_hsa000520.27207349
105Fructose and mannose metabolism_Homo sapiens_hsa000510.26919656
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25688247
107Lysosome_Homo sapiens_hsa041420.18937554
108Glucagon signaling pathway_Homo sapiens_hsa049220.18536192
109Linoleic acid metabolism_Homo sapiens_hsa005910.16727646
110Insulin signaling pathway_Homo sapiens_hsa049100.13385413
111Other glycan degradation_Homo sapiens_hsa005110.12577471
112Pertussis_Homo sapiens_hsa051330.08135428
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03918909
114Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1325109
115Osteoclast differentiation_Homo sapiens_hsa04380-0.1234795
116Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1216446
117Malaria_Homo sapiens_hsa05144-0.1212671
118Legionellosis_Homo sapiens_hsa05134-0.1155379
119Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0945183
120Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0911022
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0879911
122Hepatitis C_Homo sapiens_hsa05160-0.0703769
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0602198
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0598290
125Amoebiasis_Homo sapiens_hsa05146-0.0534679
126Renin-angiotensin system_Homo sapiens_hsa04614-0.0207029
127* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0123353
128Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0046218

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »