CEBPD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)4.68031051
2response to peptidoglycan (GO:0032494)4.14041559
3negative regulation of leukocyte chemotaxis (GO:0002689)4.03353125
4detection of other organism (GO:0098543)4.01043685
5detection of bacterium (GO:0016045)3.83886663
6positive regulation of p38MAPK cascade (GO:1900745)3.79362210
7detection of external biotic stimulus (GO:0098581)3.69673179
8negative regulation of interleukin-12 production (GO:0032695)3.68785463
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65683968
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60676687
11negative regulation of cell killing (GO:0031342)3.60676687
12keratan sulfate catabolic process (GO:0042340)3.57859765
13positive regulation of gamma-delta T cell activation (GO:0046645)3.51951909
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40811252
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.40811252
16modulation by symbiont of host immune response (GO:0052553)3.40811252
17positive regulation by symbiont of host defense response (GO:0052509)3.40811252
18modulation by symbiont of host defense response (GO:0052031)3.40811252
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40811252
20antigen processing and presentation of endogenous antigen (GO:0019883)3.31643813
21regulation of T-helper 2 cell differentiation (GO:0045628)3.30303524
22neutrophil activation involved in immune response (GO:0002283)3.30134935
23regulation of mononuclear cell migration (GO:0071675)3.29865713
24detection of biotic stimulus (GO:0009595)3.24250822
25macrophage activation (GO:0042116)3.24082714
26regulation of macrophage chemotaxis (GO:0010758)3.14929486
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14564614
28germinal center formation (GO:0002467)3.13838002
29endodermal cell differentiation (GO:0035987)3.12845144
30blood vessel maturation (GO:0001955)3.10760113
31response to type I interferon (GO:0034340)3.10272205
32negative regulation of erythrocyte differentiation (GO:0045647)3.09675392
33type I interferon signaling pathway (GO:0060337)3.09601778
34cellular response to type I interferon (GO:0071357)3.09601778
35endothelial cell morphogenesis (GO:0001886)3.03659012
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03518046
37sequestering of metal ion (GO:0051238)3.01531254
38regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.00055448
39regulation of p38MAPK cascade (GO:1900744)2.99058157
40negative regulation of interleukin-8 production (GO:0032717)2.96588934
41wound healing, spreading of epidermal cells (GO:0035313)2.96572626
42skin morphogenesis (GO:0043589)2.96535511
43positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.93901247
44neutrophil mediated immunity (GO:0002446)2.93862507
45surfactant homeostasis (GO:0043129)2.92168914
46mesenchymal-epithelial cell signaling (GO:0060638)2.91574688
47macrophage activation involved in immune response (GO:0002281)2.91446841
48protein heterotrimerization (GO:0070208)2.90724687
49response to laminar fluid shear stress (GO:0034616)2.89645811
50cell adhesion mediated by integrin (GO:0033627)2.87746139
51immunoglobulin mediated immune response (GO:0016064)2.86946824
52mannose metabolic process (GO:0006013)2.86034710
53negative regulation of cytokine production involved in immune response (GO:0002719)2.84802317
54response to progesterone (GO:0032570)2.81205282
55defense response to protozoan (GO:0042832)2.81020804
56lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80901307
57collagen fibril organization (GO:0030199)2.80452860
58positive regulation of cellular amide metabolic process (GO:0034250)2.79860283
59response to fungus (GO:0009620)2.79638736
60collagen metabolic process (GO:0032963)2.77229702
61detection of molecule of bacterial origin (GO:0032490)2.77124145
62regulation of gamma-delta T cell activation (GO:0046643)2.73516337
63extracellular matrix assembly (GO:0085029)2.72050007
64apoptotic cell clearance (GO:0043277)2.71285520
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70803112
66response to host immune response (GO:0052572)2.70803112
67wound healing, spreading of cells (GO:0044319)2.70341993
68regulation of mast cell degranulation (GO:0043304)2.69876116
69interferon-gamma-mediated signaling pathway (GO:0060333)2.69781360
70positive regulation of osteoblast proliferation (GO:0033690)2.69283480
71vascular endothelial growth factor signaling pathway (GO:0038084)2.67660496
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67134617
73response to protozoan (GO:0001562)2.66540039
74myeloid cell activation involved in immune response (GO:0002275)2.66202623
75regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65703090
76collagen catabolic process (GO:0030574)2.65644965
77regulation of apoptotic cell clearance (GO:2000425)2.64674805
78defense response to fungus (GO:0050832)2.64224509
79complement activation, alternative pathway (GO:0006957)2.64052539
80retina vasculature morphogenesis in camera-type eye (GO:0061299)2.63562558
81positive regulation of type 2 immune response (GO:0002830)2.63069397
82positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63013128
83regulation of monocyte chemotaxis (GO:0090025)2.62786132
84leukocyte migration involved in inflammatory response (GO:0002523)2.60978444
85basement membrane organization (GO:0071711)2.59772775
86regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.59708756
87regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57269959
88multicellular organismal macromolecule metabolic process (GO:0044259)2.57245068
89cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57184309
90regulation of type 2 immune response (GO:0002828)2.56816410
91negative regulation of interleukin-6 production (GO:0032715)2.56734606
92reactive oxygen species biosynthetic process (GO:1903409)2.56421918
93positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56047634
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55469353
95response to host (GO:0075136)2.55469353
96response to host defenses (GO:0052200)2.55469353
97regulation of leukocyte degranulation (GO:0043300)2.55409482
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.55106469
99production of molecular mediator involved in inflammatory response (GO:0002532)2.54587245
100regulation of tolerance induction (GO:0002643)2.54031785
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53913127
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53913127
103response to muramyl dipeptide (GO:0032495)2.53061208
104regulation of chemokine biosynthetic process (GO:0045073)2.53023417
105positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52764816
106respiratory burst (GO:0045730)2.52594004
107hydrogen peroxide biosynthetic process (GO:0050665)2.52466059
108lymph vessel development (GO:0001945)2.51570584
109negative regulation of type 2 immune response (GO:0002829)2.51442872
110leukocyte aggregation (GO:0070486)2.50729428
111negative regulation of lymphocyte mediated immunity (GO:0002707)2.50277976
112regulation of T cell tolerance induction (GO:0002664)2.49136659
113multicellular organismal catabolic process (GO:0044243)2.48217770
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47456048
115pattern specification involved in kidney development (GO:0061004)2.47159607
116regulation of antigen processing and presentation (GO:0002577)2.46632315
117negative regulation of stress fiber assembly (GO:0051497)2.46002836
118response to fluid shear stress (GO:0034405)2.45568213
119negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45494748
120neutrophil activation (GO:0042119)2.45408085
121negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45353344
122multicellular organismal metabolic process (GO:0044236)2.44724859
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44607156
124regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.44144422
125regulation of mast cell activation involved in immune response (GO:0033006)2.43971925
126positive regulation of endothelial cell apoptotic process (GO:2000353)2.43747233
127regulation of T-helper 1 cell differentiation (GO:0045625)2.42897903
128positive regulation of antigen processing and presentation (GO:0002579)2.41922732
129regulation of interferon-alpha production (GO:0032647)2.41752140
130monocyte chemotaxis (GO:0002548)2.41741214
131positive regulation of tumor necrosis factor production (GO:0032760)2.41413950
132glial cell migration (GO:0008347)2.40508726
133negative regulation of leukocyte mediated immunity (GO:0002704)2.40069174
134macrophage differentiation (GO:0030225)2.39423632
135negative regulation of innate immune response (GO:0045824)2.39405216
136regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.38143090
137extracellular matrix disassembly (GO:0022617)2.37874148
138growth hormone receptor signaling pathway (GO:0060396)2.37866231
139barbed-end actin filament capping (GO:0051016)2.37378590
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.36912591
141cellular response to thyroid hormone stimulus (GO:0097067)2.36585068
142regulation of interferon-beta biosynthetic process (GO:0045357)2.36180248
143granulocyte activation (GO:0036230)2.35297109
144regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.34739758
145myeloid leukocyte mediated immunity (GO:0002444)2.33562410
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33211933
147T-helper 1 type immune response (GO:0042088)2.32381906
148positive regulation of tolerance induction (GO:0002645)2.31641919
149regulation of tumor necrosis factor production (GO:0032680)2.31277096
150myeloid dendritic cell differentiation (GO:0043011)2.30546026
151chronic inflammatory response (GO:0002544)2.29752194
152positive regulation of chemokine biosynthetic process (GO:0045080)2.29710147
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29541584
154positive regulation of interferon-alpha production (GO:0032727)2.28486468
155response to interferon-alpha (GO:0035455)2.28468482
156negative regulation of production of molecular mediator of immune response (GO:0002701)2.28421970
157regulation of interleukin-6 production (GO:0032675)2.28183813
158microglial cell activation (GO:0001774)2.27013073
159neutrophil chemotaxis (GO:0030593)2.25613123
160regulation of endothelial cell differentiation (GO:0045601)2.24486558
161response to increased oxygen levels (GO:0036296)2.22777715
162response to hyperoxia (GO:0055093)2.22777715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.77906365
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.76134516
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.79864336
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.59843306
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40701713
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.34752056
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.23746964
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88710612
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.84459569
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.79160193
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69804024
12CLOCK_20551151_ChIP-Seq_293T_Human2.66378371
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.55143472
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46914491
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.38620592
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.38358493
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.24049158
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23420086
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17989726
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.16987993
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.12870280
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.10806150
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09785997
24* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98877572
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.96252387
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95749894
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95582229
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83582025
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81697794
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81366995
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.81358400
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80879682
33ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.75993611
34* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74643755
35* VDR_24763502_ChIP-Seq_THP-1_Human1.70028604
36* CJUN_26792858_Chip-Seq_BT549_Human1.67057276
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65199439
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.64862746
39KDM2B_26808549_Chip-Seq_DND41_Human1.63814668
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.63422149
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61458874
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55098739
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55098739
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54377503
45* SOX2_20726797_ChIP-Seq_SW620_Human1.51710071
46* VDR_21846776_ChIP-Seq_THP-1_Human1.50241694
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49059824
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.48707057
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48586211
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46828840
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44743371
52JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43326563
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41766394
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37220551
55* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34733788
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33323468
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.33148326
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30498675
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30498675
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30251599
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29752848
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29079377
63MAF_26560356_Chip-Seq_TH1_Human1.28770141
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.28043490
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28008807
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27359401
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27203738
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.26336734
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25658238
70RACK7_27058665_Chip-Seq_MCF-7_Human1.25566107
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.25312223
72* VDR_24787735_ChIP-Seq_THP-1_Human1.24516904
73* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23953335
74BRD4_25478319_ChIP-Seq_HGPS_Human1.23108869
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.22936792
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22442891
77KDM2B_26808549_Chip-Seq_K562_Human1.21582502
78LXR_22292898_ChIP-Seq_THP-1_Human1.21208554
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21187571
80UTX_26944678_Chip-Seq_JUKART_Human1.18405396
81SCL_19346495_ChIP-Seq_HPC-7_Human1.17844191
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17647643
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16316973
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16268520
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15624226
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15599366
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15366468
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15322820
89GATA1_19941826_ChIP-Seq_K562_Human1.14914701
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14431184
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.12941775
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12345346
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11706935
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11411266
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09862405
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09736965
97* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09580084
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09490567
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09317800
100SPI1_23547873_ChIP-Seq_NB4_Human1.08967681
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07428140
102SPI1_23127762_ChIP-Seq_K562_Human1.06344014
103RUNX_20019798_ChIP-Seq_JUKART_Human1.06024260
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04919231
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.04817744
106* TCF7_22412390_ChIP-Seq_EML_Mouse1.04602481
107ATF3_27146783_Chip-Seq_COLON_Human1.03823417
108MAF_26560356_Chip-Seq_TH2_Human1.03019354
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02638016
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.02621685
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.02621685
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02485856
113* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02046051
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.00358492
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00219187
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00122165
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00105526
118SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00060216
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99816614
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98842178
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98092520
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97881441
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97235359
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96906812
125PU_27001747_Chip-Seq_BMDM_Mouse0.95636701
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95437244
127MYC_22102868_ChIP-Seq_BL_Human0.94377778
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94284407
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94103546
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93937094
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93338998
132* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93187987
133EGR1_19032775_ChIP-ChIP_M12_Human0.92149581
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91928313
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90482710
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89753695
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89140293
138BCOR_27268052_Chip-Seq_Bcells_Human0.87728841
139SMC4_20622854_ChIP-Seq_HELA_Human0.87280139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.50934171
2MP0003279_aneurysm3.52627054
3MP0005275_abnormal_skin_tensile3.50163391
4MP0003724_increased_susceptibility_to3.27870292
5MP0003303_peritoneal_inflammation3.23688393
6MP0005503_abnormal_tendon_morphology3.22989236
7MP0001958_emphysema3.20244433
8MP0003705_abnormal_hypodermis_morpholog2.59166852
9MP0000343_altered_response_to2.48929019
10MP0003436_decreased_susceptibility_to2.45286940
11MP0009278_abnormal_bone_marrow2.27289934
12MP0005023_abnormal_wound_healing2.13288547
13MP0005257_abnormal_intraocular_pressure2.08434949
14MP0003300_gastrointestinal_ulcer2.02793580
15MP0009785_altered_susceptibility_to2.01841457
16MP0001533_abnormal_skeleton_physiology2.01095870
17MP0004272_abnormal_basement_membrane1.95295985
18MP0001879_abnormal_lymphatic_vessel1.87504243
19MP0009384_cardiac_valve_regurgitation1.85275671
20MP0003828_pulmonary_edema1.80478371
21MP0005164_abnormal_response_to1.72750579
22MP0010368_abnormal_lymphatic_system1.72364925
23MP0002419_abnormal_innate_immunity1.71287465
24MP0002148_abnormal_hypersensitivity_rea1.71217653
25MP0002060_abnormal_skin_morphology1.67502130
26MP0009840_abnormal_foam_cell1.66727122
27MP0002933_joint_inflammation1.66423562
28MP0002295_abnormal_pulmonary_circulatio1.65258178
29MP0005390_skeleton_phenotype1.64153511
30MP0003566_abnormal_cell_adhesion1.63787231
31MP0005671_abnormal_response_to1.57974632
32MP0005451_abnormal_body_composition1.54433494
33MP0006054_spinal_hemorrhage1.53517217
34MP0003448_altered_tumor_morphology1.53005503
35MP0005167_abnormal_blood-brain_barrier1.51977621
36MP0005508_abnormal_skeleton_morphology1.49216501
37MP0008260_abnormal_autophagy1.47811203
38MP0000750_abnormal_muscle_regeneration1.46806771
39MP0009764_decreased_sensitivity_to1.45508520
40MP0002877_abnormal_melanocyte_morpholog1.44171806
41MP0000858_altered_metastatic_potential1.41758888
42MP0003091_abnormal_cell_migration1.41642095
43MP0000767_abnormal_smooth_muscle1.40209062
44MP0003172_abnormal_lysosome_physiology1.38346703
45MP0002998_abnormal_bone_remodeling1.36104915
46MP0003075_altered_response_to1.35364479
47MP0010352_gastrointestinal_tract_polyps1.33168119
48MP0003690_abnormal_glial_cell1.32788439
49MP0004883_abnormal_blood_vessel1.29994851
50MP0005000_abnormal_immune_tolerance1.26431544
51MP0005025_abnormal_response_to1.26067101
52MP0001853_heart_inflammation1.20840957
53MP0000249_abnormal_blood_vessel1.20755963
54MP0000604_amyloidosis1.18119441
55MP0001851_eye_inflammation1.17562482
56MP0002405_respiratory_system_inflammati1.14229405
57MP0004858_abnormal_nervous_system1.12199486
58MP0001545_abnormal_hematopoietic_system1.11688110
59MP0005397_hematopoietic_system_phenotyp1.11688110
60MP0002132_abnormal_respiratory_system1.10442473
61MP0003011_delayed_dark_adaptation1.07495546
62MP0003453_abnormal_keratinocyte_physiol1.07152390
63MP0002166_altered_tumor_susceptibility1.05832929
64MP0005595_abnormal_vascular_smooth1.05307495
65MP0004510_myositis1.04924459
66MP0009333_abnormal_splenocyte_physiolog1.04877567
67MP0005388_respiratory_system_phenotype1.04200365
68MP0002133_abnormal_respiratory_system1.04200365
69MP0000733_abnormal_muscle_development1.02709849
70MP0000716_abnormal_immune_system1.02150779
71MP0001845_abnormal_inflammatory_respons1.01486485
72MP0005058_abnormal_lysosome_morphology1.01380803
73MP0001542_abnormal_bone_strength1.00763289
74MP0001790_abnormal_immune_system1.00073251
75MP0005387_immune_system_phenotype1.00073251
76MP0005165_increased_susceptibility_to0.99332897
77MP0005166_decreased_susceptibility_to0.99164052
78MP0003795_abnormal_bone_structure0.98827198
79MP0001835_abnormal_antigen_presentation0.98218963
80MP0002452_abnormal_antigen_presenting0.96994555
81MP0005197_abnormal_uvea_morphology0.96200773
82MP0002332_abnormal_exercise_endurance0.95582514
83MP0004947_skin_inflammation0.95538044
84MP0002896_abnormal_bone_mineralization0.95254085
85MP0009379_abnormal_foot_pigmentation0.93830878
86MP0000685_abnormal_immune_system0.93358222
87MP0002277_abnormal_respiratory_mucosa0.92957267
88MP0002138_abnormal_hepatobiliary_system0.92701529
89MP0003191_abnormal_cellular_cholesterol0.92679105
90MP0010155_abnormal_intestine_physiology0.91469546
91MP0004808_abnormal_hematopoietic_stem0.90799009
92MP0002108_abnormal_muscle_morphology0.90254379
93MP0004782_abnormal_surfactant_physiolog0.89022575
94MP0009763_increased_sensitivity_to0.87751874
95MP0003763_abnormal_thymus_physiology0.87615861
96MP0008004_abnormal_stomach_pH0.87146627
97* MP0005076_abnormal_cell_differentiation0.83113532
98MP0002006_tumorigenesis0.82099240
99MP0003866_abnormal_defecation0.82087202
100MP0008469_abnormal_protein_level0.82039523
101MP0002723_abnormal_immune_serum0.81517542
102MP0003045_fibrosis0.81449986
103MP0003183_abnormal_peptide_metabolism0.81035934
104MP0002398_abnormal_bone_marrow0.80167558
105MP0002139_abnormal_hepatobiliary_system0.80063346
106MP0000465_gastrointestinal_hemorrhage0.80037792
107MP0006082_CNS_inflammation0.79344217
108MP0001243_abnormal_dermal_layer0.79129119
109MP0001663_abnormal_digestive_system0.79087717
110MP0001175_abnormal_lung_morphology0.78508202
111MP0000163_abnormal_cartilage_morphology0.76019796
112MP0001614_abnormal_blood_vessel0.75295846
113MP0005666_abnormal_adipose_tissue0.75025458
114MP0002420_abnormal_adaptive_immunity0.74291052
115MP0002254_reproductive_system_inflammat0.74273237
116MP0001819_abnormal_immune_cell0.74093229
117MP0002429_abnormal_blood_cell0.73098580
118MP0008874_decreased_physiological_sensi0.71207709
119MP0003186_abnormal_redox_activity0.70525036
120MP0001800_abnormal_humoral_immune0.70364387
121MP0002113_abnormal_skeleton_development0.70200114
122MP0002722_abnormal_immune_system0.69729601
123MP0005310_abnormal_salivary_gland0.69026707
124MP0005464_abnormal_platelet_physiology0.68906915
125MP0002128_abnormal_blood_circulation0.68052479
126MP0003329_amyloid_beta_deposits0.67790762
127MP0005375_adipose_tissue_phenotype0.66305373
128MP0003879_abnormal_hair_cell0.65599939

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.72211923
2Premature rupture of membranes (HP:0001788)5.57989940
3Eczematoid dermatitis (HP:0000976)4.28412011
4Ankle contracture (HP:0006466)3.94926969
5Optic neuritis (HP:0100653)3.87789358
6Retrobulbar optic neuritis (HP:0100654)3.87789358
7Peritonitis (HP:0002586)3.86200166
8Abnormality of glycolipid metabolism (HP:0010969)3.71616741
9Abnormality of liposaccharide metabolism (HP:0010968)3.71616741
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.71616741
11Complement deficiency (HP:0004431)3.69901329
12Vertebral compression fractures (HP:0002953)3.59986373
13Cervical subluxation (HP:0003308)3.57997905
14Soft skin (HP:0000977)3.55477824
15Abnormality of complement system (HP:0005339)3.55288996
16Cerebral aneurysm (HP:0004944)3.50865440
17Recurrent abscess formation (HP:0002722)3.49907014
18Shallow orbits (HP:0000586)3.48607207
19Broad metatarsal (HP:0001783)3.37076043
20Hematochezia (HP:0002573)3.31500290
21Aortic aneurysm (HP:0004942)3.24270233
22Aortic dissection (HP:0002647)3.24108627
23Atrophic scars (HP:0001075)3.22417918
24Vascular tortuosity (HP:0004948)3.20757423
25Interstitial pulmonary disease (HP:0006530)3.15561017
26Recurrent gram-negative bacterial infections (HP:0005420)3.12659508
27Increased IgE level (HP:0003212)3.06094002
28Recurrent bacterial skin infections (HP:0005406)3.04072102
29Dilatation of the ascending aorta (HP:0005111)2.94107761
30Keratoconjunctivitis sicca (HP:0001097)2.93885467
31Wrist flexion contracture (HP:0001239)2.92005182
32Increased connective tissue (HP:0009025)2.91899026
33Stomatitis (HP:0010280)2.88812795
34Spontaneous hematomas (HP:0007420)2.88320383
35Axonal loss (HP:0003447)2.87434088
36Fragile skin (HP:0001030)2.82878269
37Spinal rigidity (HP:0003306)2.82552270
38Arterial tortuosity (HP:0005116)2.78900988
39Osteolytic defects of the hand bones (HP:0009699)2.71171273
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.71171273
41Keratoconjunctivitis (HP:0001096)2.62867411
42Wormian bones (HP:0002645)2.60934869
43Dysostosis multiplex (HP:0000943)2.59912235
44Gastrointestinal infarctions (HP:0005244)2.56973383
45Bladder diverticulum (HP:0000015)2.54679339
46Purpura (HP:0000979)2.53939330
47Follicular hyperkeratosis (HP:0007502)2.52979534
48Loss of speech (HP:0002371)2.52348478
49Abnormality of macrophages (HP:0004311)2.51636439
50Meningitis (HP:0001287)2.50826096
51Pulmonary infiltrates (HP:0002113)2.49028078
52Hemoptysis (HP:0002105)2.48680357
53Recurrent skin infections (HP:0001581)2.47755079
54Myositis (HP:0100614)2.46084290
55Urinary glycosaminoglycan excretion (HP:0003541)2.42828507
56Mucopolysacchariduria (HP:0008155)2.42828507
57Mitral valve prolapse (HP:0001634)2.41430653
58Vasculitis (HP:0002633)2.39697345
59Recurrent fungal infections (HP:0002841)2.38864559
60Biconcave vertebral bodies (HP:0004586)2.37200805
61Malnutrition (HP:0004395)2.36623255
62Systemic lupus erythematosus (HP:0002725)2.35117567
63Type 1 muscle fiber predominance (HP:0003803)2.31627837
64Elevated erythrocyte sedimentation rate (HP:0003565)2.30714771
65Gingivitis (HP:0000230)2.29972657
66Nonimmune hydrops fetalis (HP:0001790)2.28783903
67Blue sclerae (HP:0000592)2.28690869
68Vacuolated lymphocytes (HP:0001922)2.25387204
69Increased serum ferritin (HP:0003281)2.24153779
70Myocardial infarction (HP:0001658)2.24052803
71Orchitis (HP:0100796)2.23236867
72Abnormality of the distal phalanges of the toes (HP:0010182)2.21023019
73Pulmonary embolism (HP:0002204)2.18647393
74Slender build (HP:0001533)2.18171755
75Hyperextensible skin (HP:0000974)2.17182299
76Asymmetric septal hypertrophy (HP:0001670)2.16546170
77Cellulitis (HP:0100658)2.15719887
78Pulmonary artery stenosis (HP:0004415)2.15338562
79Generalized amyotrophy (HP:0003700)2.15252249
80Segmental peripheral demyelination/remyelination (HP:0003481)2.14969563
81Episodic fever (HP:0001954)2.14902170
82Joint stiffness (HP:0001387)2.14594136
83Abnormality of polysaccharide metabolism (HP:0011012)2.12662355
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12662355
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12662355
86Gangrene (HP:0100758)2.10483407
87Aneurysm (HP:0002617)2.09704206
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.07862685
89Arterial thrombosis (HP:0004420)2.05255173
90Gingival bleeding (HP:0000225)2.03578429
91Spondylolisthesis (HP:0003302)2.01718007
92Mediastinal lymphadenopathy (HP:0100721)2.01664302
93Epistaxis (HP:0000421)2.01406687
94Abnormality of the pleura (HP:0002103)1.99684987
95Genu recurvatum (HP:0002816)1.99433987
96Broad ribs (HP:0000885)1.98184793
97Hypergammaglobulinemia (HP:0010702)1.97627287
98Prolonged bleeding time (HP:0003010)1.96688923
99Chest pain (HP:0100749)1.96039628
100Colitis (HP:0002583)1.95853372
101Neurofibrillary tangles (HP:0002185)1.94905722
102Abnormality of iron homeostasis (HP:0011031)1.94688470
103Acne (HP:0001061)1.94673276
104Distal lower limb muscle weakness (HP:0009053)1.94422172
105Muscle fiber splitting (HP:0003555)1.94166388
106Camptodactyly of toe (HP:0001836)1.93686861
107Encephalitis (HP:0002383)1.93233421
108Elbow flexion contracture (HP:0002987)1.91087707
109Short hallux (HP:0010109)1.91063503
110Increased density of long bones (HP:0006392)1.89012200
111Abnormality of the peritoneum (HP:0002585)1.86965480
112Flexion contracture of toe (HP:0005830)1.86478885
113Joint contractures involving the joints of the feet (HP:0100492)1.86478885
114Hemorrhage of the eye (HP:0011885)1.86424226
115Thoracolumbar scoliosis (HP:0002944)1.85831644
116Neonatal short-limb short stature (HP:0008921)1.85763497
117Amyloidosis (HP:0011034)1.85673045
118Rectal prolapse (HP:0002035)1.84828023
119Aortic valve stenosis (HP:0001650)1.84660614
120Beaking of vertebral bodies (HP:0004568)1.84123620
121Petechiae (HP:0000967)1.82781648
122Short nail (HP:0001799)1.81973491
123Abnormality of the acetabulum (HP:0003170)1.80993132
124Mildly elevated creatine phosphokinase (HP:0008180)1.80824399
125Abnormality of the odontoid process (HP:0003310)1.80361828
126Polycythemia (HP:0001901)1.80349612
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.80046510
128Osteomyelitis (HP:0002754)1.79455816
129Mitral regurgitation (HP:0001653)1.78984402
130Polygenic inheritance (HP:0010982)1.78704311
131Emphysema (HP:0002097)1.77433108
132Ovoid vertebral bodies (HP:0003300)1.77225547
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.76489835
134Nephritis (HP:0000123)1.75991088
135Leukocytosis (HP:0001974)1.75561747
136Chondrocalcinosis (HP:0000934)1.75306288
137Thick nail (HP:0001805)1.73734270
138Nasal polyposis (HP:0100582)1.73344835
139Nuclear cataract (HP:0100018)1.73217115
140Inflammation of the large intestine (HP:0002037)1.73149938
141Overgrowth (HP:0001548)1.72965772
142Chronic obstructive pulmonary disease (HP:0006510)1.72688835
143Obstructive lung disease (HP:0006536)1.72688835
144Anorexia (HP:0002039)1.72340247
145Abnormality of the nasal mucosa (HP:0000433)1.72162426
146Esophageal varix (HP:0002040)1.72161199
147Vertigo (HP:0002321)1.71732546
148Abnormal delivery (HP:0001787)1.71112165
149Increased variability in muscle fiber diameter (HP:0003557)1.70940016
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70928450
151Abnormality of the pericardium (HP:0001697)1.68722211
152Coxa vara (HP:0002812)1.68463925
153Abnormality of the lumbar spine (HP:0100712)1.66226741
154Increased cerebral lipofuscin (HP:0011813)1.65901490
155Urticaria (HP:0001025)1.65477043
156Glomerulonephritis (HP:0000099)1.64942393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.60054374
2TGFBR23.05525812
3EPHB12.80800836
4MAP3K32.70578707
5TRIB32.60909402
6PRPF4B2.42793758
7EPHA32.27616418
8RIPK12.14893230
9BLK2.12016431
10IRAK32.03116374
11MAP4K12.01522771
12MAPK151.90520965
13TBK11.87228548
14IRAK41.85694676
15PIM21.84504749
16TIE11.83368852
17KDR1.76460163
18TTN1.73575781
19MAP2K31.64043458
20STK101.63960326
21MAP2K21.62578884
22CSK1.59156612
23MOS1.58822742
24TYK21.57919333
25TAOK21.57598632
26RPS6KA41.54992170
27LRRK21.53481033
28MAP3K141.52218171
29TEC1.49043707
30NME21.47627023
31MAP3K61.45429035
32TRPM71.43385434
33CDC42BPA1.35257011
34DDR21.34205559
35EPHB21.31530293
36GRK71.30014508
37PTK61.29318651
38NLK1.28611314
39PAK41.27708980
40FGFR41.27570456
41TNK21.26259522
42RIPK41.19329551
43PDGFRA1.19047761
44KIT1.16817334
45PTK21.16576870
46GRK61.16436734
47NEK91.15944888
48TESK11.14455656
49IKBKB1.14293977
50MARK21.12357629
51BMX1.11972977
52FGR1.10161021
53JAK11.07518650
54IKBKE1.06910538
55PKN21.06432359
56PRKD21.04366766
57PDPK11.01203314
58MAP3K131.00379278
59PRKG20.99139346
60PAK20.97237477
61MAPK70.96911207
62IRAK10.96606863
63MST1R0.96539598
64EPHA20.94854382
65BTK0.94674307
66SYK0.93534231
67FER0.91167844
68TESK20.90830011
69MST40.89929622
70DMPK0.89164866
71ZAP700.88618647
72ILK0.87855621
73ABL20.87457938
74CSF1R0.84493876
75LATS20.83317438
76HCK0.82229336
77LYN0.81424922
78GSK3A0.80453902
79PTK2B0.80440484
80IRAK20.80226075
81MAPK120.79104325
82HIPK20.78638064
83JAK30.76299222
84CLK10.74830878
85PDK10.73800266
86SMG10.73002269
87MAP3K70.71623675
88FES0.71137917
89PIK3CG0.70238576
90MAP3K10.69967469
91LCK0.69138620
92SIK10.67133541
93MYLK0.67090699
94CHUK0.67068595
95BMPR20.65812071
96MAPKAPK20.64927645
97JAK20.64176771
98STK380.64101244
99RPS6KA60.62551954
100TLK10.61691678
101RPS6KA20.61487650
102PIM10.61310080
103MAPK40.60678275
104TGFBR10.60499011
105RPS6KL10.58249864
106RPS6KC10.58249864
107MAPKAPK30.58239830
108KSR20.58091730
109TAOK10.57503947
110MARK30.57170332
111MATK0.57075850
112TXK0.56185282
113MAP3K110.55413608
114MAP2K60.55158360
115ITK0.53040608
116ABL10.52729430
117MAP3K20.52312801
118FLT30.51647213
119FGFR30.51625949
120PDGFRB0.49681339
121CAMK1D0.48173837
122MAP3K50.46218962
123ICK0.46159023
124TAOK30.45450077
125EIF2AK20.45244944
126FYN0.43241666
127SGK30.43059891
128PRKD10.42925824
129MET0.42389130
130RET0.41240897
131PRKAA20.39612124
132CDK60.39132172
133ROCK10.38296965
134SCYL20.37161479
135PRKCD0.35752187

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.28571661
2Leishmaniasis_Homo sapiens_hsa051402.71427526
3TNF signaling pathway_Homo sapiens_hsa046682.20835050
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.18605920
5Staphylococcus aureus infection_Homo sapiens_hsa051502.13116594
6ECM-receptor interaction_Homo sapiens_hsa045122.12997544
7Osteoclast differentiation_Homo sapiens_hsa043802.12911870
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.08471881
9Pertussis_Homo sapiens_hsa051332.04821815
10Other glycan degradation_Homo sapiens_hsa005111.91858576
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86858089
12Graft-versus-host disease_Homo sapiens_hsa053321.80449814
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80057280
14Allograft rejection_Homo sapiens_hsa053301.79900572
15Legionellosis_Homo sapiens_hsa051341.76798730
16Amoebiasis_Homo sapiens_hsa051461.73027239
17Toxoplasmosis_Homo sapiens_hsa051451.71141849
18Focal adhesion_Homo sapiens_hsa045101.68983897
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.63604094
20Autoimmune thyroid disease_Homo sapiens_hsa053201.57246393
21Lysosome_Homo sapiens_hsa041421.55197619
22Rheumatoid arthritis_Homo sapiens_hsa053231.53335019
23Tuberculosis_Homo sapiens_hsa051521.49834772
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48559686
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45597621
26Salmonella infection_Homo sapiens_hsa051321.44419025
27Phagosome_Homo sapiens_hsa041451.43439629
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.39551386
29Bladder cancer_Homo sapiens_hsa052191.38864965
30Caffeine metabolism_Homo sapiens_hsa002321.37986271
31Proteoglycans in cancer_Homo sapiens_hsa052051.34873220
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33266307
33Apoptosis_Homo sapiens_hsa042101.27902164
34Small cell lung cancer_Homo sapiens_hsa052221.26861460
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19959170
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18283862
37Adherens junction_Homo sapiens_hsa045201.17943305
38Influenza A_Homo sapiens_hsa051641.15239836
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14300639
40Shigellosis_Homo sapiens_hsa051311.13731067
41Chronic myeloid leukemia_Homo sapiens_hsa052201.09324571
42Type I diabetes mellitus_Homo sapiens_hsa049401.05589784
43Hepatitis B_Homo sapiens_hsa051611.04245146
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03211285
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01801943
46African trypanosomiasis_Homo sapiens_hsa051431.00016113
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.99732225
48Protein digestion and absorption_Homo sapiens_hsa049740.99623352
49Measles_Homo sapiens_hsa051620.99172761
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99113583
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98750292
52Hematopoietic cell lineage_Homo sapiens_hsa046400.98374044
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95928580
54Acute myeloid leukemia_Homo sapiens_hsa052210.95221270
55Chemokine signaling pathway_Homo sapiens_hsa040620.94180169
56TGF-beta signaling pathway_Homo sapiens_hsa043500.93454691
57Platelet activation_Homo sapiens_hsa046110.91408151
58B cell receptor signaling pathway_Homo sapiens_hsa046620.90724369
59Viral myocarditis_Homo sapiens_hsa054160.87724761
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87490266
61Herpes simplex infection_Homo sapiens_hsa051680.86873549
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86759577
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85434409
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84976622
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84423522
66Pancreatic cancer_Homo sapiens_hsa052120.84019570
67Complement and coagulation cascades_Homo sapiens_hsa046100.82322170
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.80279453
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.80233869
70Antigen processing and presentation_Homo sapiens_hsa046120.79751474
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79272617
72Prion diseases_Homo sapiens_hsa050200.79120344
73HIF-1 signaling pathway_Homo sapiens_hsa040660.79107268
74Insulin resistance_Homo sapiens_hsa049310.77988248
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77529070
76MicroRNAs in cancer_Homo sapiens_hsa052060.77235193
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76259299
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74678456
79Mineral absorption_Homo sapiens_hsa049780.72629064
80Pathways in cancer_Homo sapiens_hsa052000.72580778
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71407824
82Hepatitis C_Homo sapiens_hsa051600.71268480
83T cell receptor signaling pathway_Homo sapiens_hsa046600.71004613
84Melanoma_Homo sapiens_hsa052180.70858595
85Ribosome_Homo sapiens_hsa030100.67471006
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67134935
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64715329
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64150664
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.63972639
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63936618
91GnRH signaling pathway_Homo sapiens_hsa049120.62750172
92HTLV-I infection_Homo sapiens_hsa051660.61822513
93Prolactin signaling pathway_Homo sapiens_hsa049170.61759636
94Prostate cancer_Homo sapiens_hsa052150.61568057
95Asthma_Homo sapiens_hsa053100.61463900
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60866252
97p53 signaling pathway_Homo sapiens_hsa041150.60198663
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.60062554
99Rap1 signaling pathway_Homo sapiens_hsa040150.59212764
100Starch and sucrose metabolism_Homo sapiens_hsa005000.57960973
101Endocytosis_Homo sapiens_hsa041440.55545621
102Protein export_Homo sapiens_hsa030600.53654408
103Renin-angiotensin system_Homo sapiens_hsa046140.52647059
104VEGF signaling pathway_Homo sapiens_hsa043700.52366423
105Dorso-ventral axis formation_Homo sapiens_hsa043200.51982480
106Renal cell carcinoma_Homo sapiens_hsa052110.51565557
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50972091
108PPAR signaling pathway_Homo sapiens_hsa033200.50749530
109Primary immunodeficiency_Homo sapiens_hsa053400.47615482
110N-Glycan biosynthesis_Homo sapiens_hsa005100.47586234
111Notch signaling pathway_Homo sapiens_hsa043300.47491524
112Sulfur metabolism_Homo sapiens_hsa009200.47252399
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46817101
114Arachidonic acid metabolism_Homo sapiens_hsa005900.46742319
115Dilated cardiomyopathy_Homo sapiens_hsa054140.45995930
116FoxO signaling pathway_Homo sapiens_hsa040680.44921661
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.44579678
118Non-small cell lung cancer_Homo sapiens_hsa052230.44324955
119Galactose metabolism_Homo sapiens_hsa000520.43901968
120MAPK signaling pathway_Homo sapiens_hsa040100.43481493
121Fructose and mannose metabolism_Homo sapiens_hsa000510.43280642
122Sphingolipid metabolism_Homo sapiens_hsa006000.41867702
123Type II diabetes mellitus_Homo sapiens_hsa049300.41358673
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38754432
125Choline metabolism in cancer_Homo sapiens_hsa052310.38407930
126mTOR signaling pathway_Homo sapiens_hsa041500.38250934
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37887671
128Insulin signaling pathway_Homo sapiens_hsa049100.36784597
129Histidine metabolism_Homo sapiens_hsa003400.35826750
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35270252

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »