CEBPZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.94857623
2nuclear pore complex assembly (GO:0051292)4.93402281
3DNA unwinding involved in DNA replication (GO:0006268)4.79611124
4maturation of SSU-rRNA (GO:0030490)4.74778230
5folic acid-containing compound biosynthetic process (GO:0009396)4.30447648
6formation of translation preinitiation complex (GO:0001731)4.29721894
7nucleobase biosynthetic process (GO:0046112)4.22898212
8DNA replication initiation (GO:0006270)4.14991144
9ribosomal small subunit assembly (GO:0000028)4.12839815
10ribosomal large subunit biogenesis (GO:0042273)4.12583459
11translational termination (GO:0006415)4.10446491
12viral transcription (GO:0019083)4.10338447
13maturation of 5.8S rRNA (GO:0000460)4.09057023
14protein localization to kinetochore (GO:0034501)4.05624482
15mitotic nuclear envelope disassembly (GO:0007077)4.04319508
16mitotic metaphase plate congression (GO:0007080)4.03875046
17regulation of centriole replication (GO:0046599)4.03646640
18IMP biosynthetic process (GO:0006188)4.00968181
19purine nucleobase biosynthetic process (GO:0009113)4.00328848
20ribosome assembly (GO:0042255)3.96610565
21ribosomal small subunit biogenesis (GO:0042274)3.85926458
22DNA strand elongation involved in DNA replication (GO:0006271)3.85830366
23mitotic sister chromatid cohesion (GO:0007064)3.84554304
24ribonucleoprotein complex biogenesis (GO:0022613)3.83702115
25pore complex assembly (GO:0046931)3.82723434
26metaphase plate congression (GO:0051310)3.79631692
27nuclear envelope disassembly (GO:0051081)3.77433601
28membrane disassembly (GO:0030397)3.77433601
29ribosome biogenesis (GO:0042254)3.77180598
30kinetochore organization (GO:0051383)3.73325922
31translational initiation (GO:0006413)3.71653674
32regulation of mitotic spindle checkpoint (GO:1903504)3.71383248
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.71383248
34DNA replication-dependent nucleosome organization (GO:0034723)3.71372762
35DNA replication-dependent nucleosome assembly (GO:0006335)3.71372762
36DNA strand elongation (GO:0022616)3.69467514
37IMP metabolic process (GO:0046040)3.68784571
38translational elongation (GO:0006414)3.65257345
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63530662
40chromatin remodeling at centromere (GO:0031055)3.63361595
41DNA replication checkpoint (GO:0000076)3.60778199
42negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.59921813
43negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.59921813
44negative regulation of mitotic sister chromatid separation (GO:2000816)3.59921813
45negative regulation of sister chromatid segregation (GO:0033046)3.59921813
46DNA duplex unwinding (GO:0032508)3.59395217
47DNA geometric change (GO:0032392)3.58949789
48DNA double-strand break processing (GO:0000729)3.58639406
49negative regulation of DNA-dependent DNA replication (GO:2000104)3.57859757
50CENP-A containing nucleosome assembly (GO:0034080)3.56027177
51regulation of spindle organization (GO:0090224)3.53979556
52telomere maintenance via semi-conservative replication (GO:0032201)3.52937298
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.47737713
54rRNA processing (GO:0006364)3.47662723
55regulation of RNA export from nucleus (GO:0046831)3.43444805
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41972941
57mitotic spindle checkpoint (GO:0071174)3.41723207
58protein localization to chromosome, centromeric region (GO:0071459)3.40810912
59non-recombinational repair (GO:0000726)3.38295813
60double-strand break repair via nonhomologous end joining (GO:0006303)3.38295813
61DNA replication-independent nucleosome organization (GO:0034724)3.37899825
62DNA replication-independent nucleosome assembly (GO:0006336)3.37899825
63telomere maintenance via telomerase (GO:0007004)3.37746699
64regulation of histone H3-K9 methylation (GO:0051570)3.37305157
65rRNA metabolic process (GO:0016072)3.36454604
66mitotic chromosome condensation (GO:0007076)3.32783470
67mitotic recombination (GO:0006312)3.32021169
68regulation of mitotic sister chromatid separation (GO:0010965)3.32001399
69regulation of mitotic sister chromatid segregation (GO:0033047)3.32001399
70regulation of sister chromatid segregation (GO:0033045)3.32001399
71telomere maintenance via recombination (GO:0000722)3.30710115
72regulation of helicase activity (GO:0051095)3.29179052
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27787179
74positive regulation of chromosome segregation (GO:0051984)3.26619303
75establishment of viral latency (GO:0019043)3.26072510
76regulation of chromosome segregation (GO:0051983)3.25694399
77proteasome assembly (GO:0043248)3.25465419
78transcription from mitochondrial promoter (GO:0006390)3.24547128
79regulation of DNA endoreduplication (GO:0032875)3.24306165
80cotranslational protein targeting to membrane (GO:0006613)3.21861670
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.21478227
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21478227
83mitotic spindle assembly checkpoint (GO:0007094)3.20464299
84attachment of spindle microtubules to kinetochore (GO:0008608)3.19870783
85protein targeting to ER (GO:0045047)3.19840102
86protein complex localization (GO:0031503)3.19650159
87establishment of chromosome localization (GO:0051303)3.19319585
88pseudouridine synthesis (GO:0001522)3.18636937
89cellular protein complex disassembly (GO:0043624)3.17472411
90RNA-dependent DNA replication (GO:0006278)3.15960468
91spindle assembly checkpoint (GO:0071173)3.15485489
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13974965
93pre-miRNA processing (GO:0031054)3.13772614
94kinetochore assembly (GO:0051382)3.13613446
95negative regulation of histone methylation (GO:0031061)3.13354617
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13103979
97histone exchange (GO:0043486)3.13075921
98regulation of centrosome cycle (GO:0046605)3.12837794
99negative regulation of DNA recombination (GO:0045910)3.12567593
100viral life cycle (GO:0019058)3.11855498
101DNA ligation (GO:0006266)3.10787658
102DNA catabolic process, exonucleolytic (GO:0000738)3.10638079
103protein K6-linked ubiquitination (GO:0085020)3.10631198
104regulation of posttranscriptional gene silencing (GO:0060147)3.10247919
105regulation of gene silencing by miRNA (GO:0060964)3.10247919
106regulation of gene silencing by RNA (GO:0060966)3.10247919
107regulation of mitotic spindle organization (GO:0060236)3.08525181
108regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08391610
109nuclear-transcribed mRNA catabolic process (GO:0000956)3.08175251
110heterochromatin organization (GO:0070828)3.08007827
111spliceosomal snRNP assembly (GO:0000387)3.06648532
112telomere maintenance via telomere lengthening (GO:0010833)3.06026674
113RNA splicing, via transesterification reactions (GO:0000375)3.05566899
114establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05229049
115sister chromatid segregation (GO:0000819)3.04825572
116mitotic sister chromatid segregation (GO:0000070)3.04776381
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04189232
118RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03743115
119mRNA splicing, via spliceosome (GO:0000398)3.03743115
120tRNA aminoacylation for protein translation (GO:0006418)3.01670977
121replication fork processing (GO:0031297)3.00761170
122chromatin assembly or disassembly (GO:0006333)3.00600172
123meiotic chromosome segregation (GO:0045132)3.00464365
124amino acid activation (GO:0043038)3.00044027
125tRNA aminoacylation (GO:0043039)3.00044027
126mitochondrial RNA metabolic process (GO:0000959)2.99224319
127viral mRNA export from host cell nucleus (GO:0046784)2.99089076
128histone mRNA metabolic process (GO:0008334)2.98082013
129response to X-ray (GO:0010165)2.97322867
130inner mitochondrial membrane organization (GO:0007007)2.96810576
131protein localization to endoplasmic reticulum (GO:0070972)2.96269506
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.93775624
133protein complex disassembly (GO:0043241)2.93489985
134DNA conformation change (GO:0071103)2.92903523
135mRNA catabolic process (GO:0006402)2.92540449
136spindle checkpoint (GO:0031577)2.92114478
137establishment of integrated proviral latency (GO:0075713)2.91610035
138RNA catabolic process (GO:0006401)2.91297593
139negative regulation of chromosome segregation (GO:0051985)2.91126007
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90017150
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89669847
142nuclear envelope organization (GO:0006998)2.89115045
143negative regulation of RNA splicing (GO:0033119)2.89113721
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88763481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.97459434
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.53566657
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.99428087
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90861726
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17961725
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13207548
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12033354
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90652918
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.77621598
10* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64574528
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.59562975
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58965524
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.52295724
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46505137
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40466847
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36450692
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33903860
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.33863240
19XRN2_22483619_ChIP-Seq_HELA_Human2.26793851
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26534634
21VDR_23849224_ChIP-Seq_CD4+_Human2.23966446
22AR_21909140_ChIP-Seq_LNCAP_Human2.21218581
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19157968
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.08187661
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05632789
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03086431
27FOXP3_21729870_ChIP-Seq_TREG_Human1.99661760
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96957271
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93142506
30TTF2_22483619_ChIP-Seq_HELA_Human1.83727012
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83013146
32ELK1_19687146_ChIP-ChIP_HELA_Human1.82534741
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82434814
34DCP1A_22483619_ChIP-Seq_HELA_Human1.82152572
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.80487561
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80458377
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78006188
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76513672
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76078299
40MYC_22102868_ChIP-Seq_BL_Human1.74721704
41* GABP_19822575_ChIP-Seq_HepG2_Human1.65390444
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61751088
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58321008
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58090328
45KDM5A_27292631_Chip-Seq_BREAST_Human1.55575131
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55464312
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53425921
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52599494
49EWS_26573619_Chip-Seq_HEK293_Human1.51055924
50CIITA_25753668_ChIP-Seq_RAJI_Human1.51030812
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50493994
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50336754
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47882484
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46753179
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.45662032
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.45545338
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44563663
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43874559
59* NANOG_16153702_ChIP-ChIP_HESCs_Human1.43392143
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41734245
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37349915
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37349915
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37349915
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37089113
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36655140
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.36545645
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35788336
68FUS_26573619_Chip-Seq_HEK293_Human1.32102446
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29442772
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28530723
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28387960
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25594517
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23774158
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21651186
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19442797
76TFEB_21752829_ChIP-Seq_HELA_Human1.19271099
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19204638
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18429799
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.16019216
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13219979
81* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11105429
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10524760
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.10414804
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08020812
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06774336
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04513365
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04155449
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03537137
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03210647
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03029668
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01333454
92* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98365004
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.97826904
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.97518211
95MYC_18940864_ChIP-ChIP_HL60_Human0.97507485
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96725596
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96400242
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91044741
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89999673
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88838433
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88534750
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88524150
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87193659
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.86288758
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85663401
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85517867
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85398142
108ZNF274_21170338_ChIP-Seq_K562_Hela0.84101988
109SPI1_23547873_ChIP-Seq_NB4_Human0.82485934
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81539550
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81384320
112VDR_22108803_ChIP-Seq_LS180_Human0.81152259
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80417297
114CHD1_26751641_Chip-Seq_LNCaP_Human0.79991331
115* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79891429
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79734582
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79020465
118VDR_21846776_ChIP-Seq_THP-1_Human0.78693502
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75775797
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73284816
121* ELF5_23300383_ChIP-Seq_T47D_Human0.71279083
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71090561
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.68874227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02967324
2MP0008057_abnormal_DNA_replication4.56733543
3MP0004957_abnormal_blastocyst_morpholog4.54581171
4MP0010094_abnormal_chromosome_stability4.52264345
5MP0003111_abnormal_nucleus_morphology3.94444343
6MP0003077_abnormal_cell_cycle3.93658528
7MP0008058_abnormal_DNA_repair3.24656733
8MP0008007_abnormal_cellular_replicative2.82503958
9MP0008877_abnormal_DNA_methylation2.78404044
10MP0001730_embryonic_growth_arrest2.60063873
11MP0002396_abnormal_hematopoietic_system2.56020100
12MP0010352_gastrointestinal_tract_polyps2.47993730
13MP0008932_abnormal_embryonic_tissue2.46766297
14MP0000350_abnormal_cell_proliferation2.39606393
15MP0003123_paternal_imprinting2.19133260
16MP0009697_abnormal_copulation2.18694534
17MP0010307_abnormal_tumor_latency2.18001476
18MP0002254_reproductive_system_inflammat2.12105486
19MP0005380_embryogenesis_phenotype1.96884444
20MP0001672_abnormal_embryogenesis/_devel1.96884444
21MP0001697_abnormal_embryo_size1.90982480
22MP0003786_premature_aging1.86674852
23MP0002084_abnormal_developmental_patter1.84436748
24MP0003984_embryonic_growth_retardation1.80731260
25MP0002088_abnormal_embryonic_growth/wei1.79156889
26MP0004197_abnormal_fetal_growth/weight/1.75371387
27MP0004808_abnormal_hematopoietic_stem1.74400640
28MP0002085_abnormal_embryonic_tissue1.70487494
29MP0002086_abnormal_extraembryonic_tissu1.68916021
30MP0002080_prenatal_lethality1.67075687
31MP0003567_abnormal_fetal_cardiomyocyte1.62162591
32MP0003806_abnormal_nucleotide_metabolis1.61296956
33MP0003890_abnormal_embryonic-extraembry1.60268453
34MP0001293_anophthalmia1.49247644
35MP0003121_genomic_imprinting1.46450580
36MP0000313_abnormal_cell_death1.44688477
37MP0000490_abnormal_crypts_of1.38520629
38MP0002019_abnormal_tumor_incidence1.37774021
39MP0001188_hyperpigmentation1.30982889
40MP0006035_abnormal_mitochondrial_morpho1.29914867
41MP0006072_abnormal_retinal_apoptosis1.29858676
42MP0003763_abnormal_thymus_physiology1.25934020
43MP0002210_abnormal_sex_determination1.24418264
44MP0005076_abnormal_cell_differentiation1.23340781
45MP0002938_white_spotting1.19147304
46MP0003718_maternal_effect1.16455152
47MP0000703_abnormal_thymus_morphology1.16058277
48MP0001145_abnormal_male_reproductive1.13657770
49MP0002398_abnormal_bone_marrow1.07118583
50MP0003941_abnormal_skin_development1.06519027
51MP0002102_abnormal_ear_morphology1.06044560
52MP0001545_abnormal_hematopoietic_system1.05227304
53MP0005397_hematopoietic_system_phenotyp1.05227304
54MP0009672_abnormal_birth_weight1.05007754
55MP0006036_abnormal_mitochondrial_physio1.05003485
56MP0006292_abnormal_olfactory_placode0.99887522
57MP0000537_abnormal_urethra_morphology0.98392459
58MP0000653_abnormal_sex_gland0.97792103
59MP0000647_abnormal_sebaceous_gland0.96715274
60MP0001929_abnormal_gametogenesis0.96108831
61MP0009053_abnormal_anal_canal0.95993529
62MP0000689_abnormal_spleen_morphology0.95970531
63MP0002722_abnormal_immune_system0.95922308
64MP0003705_abnormal_hypodermis_morpholog0.95227981
65MP0001915_intracranial_hemorrhage0.95078749
66MP0009703_decreased_birth_body0.94387549
67MP0003119_abnormal_digestive_system0.94304928
68MP0002009_preneoplasia0.93455293
69MP0003937_abnormal_limbs/digits/tail_de0.90395802
70MP0002092_abnormal_eye_morphology0.90131798
71MP0004133_heterotaxia0.88682649
72MP0002233_abnormal_nose_morphology0.87386770
73MP0009333_abnormal_splenocyte_physiolog0.86750802
74MP0002111_abnormal_tail_morphology0.84176732
75MP0001286_abnormal_eye_development0.83331854
76MP0001727_abnormal_embryo_implantation0.81338168
77MP0003787_abnormal_imprinting0.80062710
78MP0002796_impaired_skin_barrier0.79962063
79MP0003136_yellow_coat_color0.78933871
80MP0002429_abnormal_blood_cell0.77949816
81MP0002751_abnormal_autonomic_nervous0.77753873
82MP0005023_abnormal_wound_healing0.77392228
83MP0004264_abnormal_extraembryonic_tissu0.76965324
84MP0005384_cellular_phenotype0.76110851
85MP0005621_abnormal_cell_physiology0.74956286
86MP0001299_abnormal_eye_distance/0.74831450
87MP0010030_abnormal_orbit_morphology0.74546605
88MP0000579_abnormal_nail_morphology0.74200706
89MP0009278_abnormal_bone_marrow0.73056240
90MP0003221_abnormal_cardiomyocyte_apopto0.70411048
91MP0002163_abnormal_gland_morphology0.70363457
92MP0000432_abnormal_head_morphology0.69083992
93MP0001119_abnormal_female_reproductive0.68655803
94MP0001177_atelectasis0.68344896
95MP0005395_other_phenotype0.68033076
96MP0000716_abnormal_immune_system0.67771018
97MP0001853_heart_inflammation0.67470893
98MP0002697_abnormal_eye_size0.67404665
99MP0001661_extended_life_span0.67279285
100MP0010234_abnormal_vibrissa_follicle0.64946947
101MP0000358_abnormal_cell_content/0.64053904
102MP0000465_gastrointestinal_hemorrhage0.63505364
103MP0000477_abnormal_intestine_morphology0.63068866
104MP0004185_abnormal_adipocyte_glucose0.62799732
105MP0005075_abnormal_melanosome_morpholog0.62535133
106MP0004215_abnormal_myocardial_fiber0.62516166
107MP0005391_vision/eye_phenotype0.61723180
108MP0008770_decreased_survivor_rate0.61476654
109MP0006054_spinal_hemorrhage0.60987316
110MP0008995_early_reproductive_senescence0.60271465
111MP0002160_abnormal_reproductive_system0.60162771
112MP0001800_abnormal_humoral_immune0.59844434
113MP0000762_abnormal_tongue_morphology0.59114898
114MP0005501_abnormal_skin_physiology0.59039254
115MP0003566_abnormal_cell_adhesion0.58656987
116MP0009379_abnormal_foot_pigmentation0.57274405
117MP0005389_reproductive_system_phenotype0.56816393
118MP0000428_abnormal_craniofacial_morphol0.56198258
119MP0005187_abnormal_penis_morphology0.55787039
120MP0005379_endocrine/exocrine_gland_phen0.55762970
121MP0002925_abnormal_cardiovascular_devel0.55492021
122MP0008789_abnormal_olfactory_epithelium0.55449488
123MP0000733_abnormal_muscle_development0.55296585
124MP0003943_abnormal_hepatobiliary_system0.55224784
125MP0003755_abnormal_palate_morphology0.55202331
126MP0003936_abnormal_reproductive_system0.55138982
127MP0003315_abnormal_perineum_morphology0.54604720
128MP0002075_abnormal_coat/hair_pigmentati0.54199025
129MP0002177_abnormal_outer_ear0.54052021
130MP0003699_abnormal_female_reproductive0.53946752
131MP0001764_abnormal_homeostasis0.53368629
132MP0003861_abnormal_nervous_system0.50426319
133MP0003186_abnormal_redox_activity0.50252912
134MP0002114_abnormal_axial_skeleton0.50142427
135MP0003935_abnormal_craniofacial_develop0.49982763

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.82261793
2Colon cancer (HP:0003003)4.23251430
3Reticulocytopenia (HP:0001896)4.20153158
4Ependymoma (HP:0002888)4.11612280
5Medulloblastoma (HP:0002885)4.05972936
6Chromsome breakage (HP:0040012)3.64988396
7Abnormality of cells of the erythroid lineage (HP:0012130)3.64645313
8Volvulus (HP:0002580)3.49698900
9Breast hypoplasia (HP:0003187)3.47951373
10Embryonal renal neoplasm (HP:0011794)3.44832648
11Rhabdomyosarcoma (HP:0002859)3.40111455
12Proximal placement of thumb (HP:0009623)3.24323756
13Selective tooth agenesis (HP:0001592)3.16472368
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11273012
15Abnormal number of erythroid precursors (HP:0012131)3.11152174
16Agnosia (HP:0010524)3.10877913
17Deviation of the thumb (HP:0009603)3.06143114
18Abnormality of chromosome stability (HP:0003220)2.99412923
19Macrocytic anemia (HP:0001972)2.95741027
20Increased hepatocellular lipid droplets (HP:0006565)2.93068596
21Myelodysplasia (HP:0002863)2.84705922
22Abnormality of the anterior horn cell (HP:0006802)2.84583465
23Degeneration of anterior horn cells (HP:0002398)2.84583465
24Basal cell carcinoma (HP:0002671)2.84200897
25Oral leukoplakia (HP:0002745)2.82960045
26Abnormality of the labia minora (HP:0012880)2.81093562
27Neoplasm of the oral cavity (HP:0100649)2.74833303
28Neoplasm of striated muscle (HP:0009728)2.74616104
29Patellar aplasia (HP:0006443)2.73135105
30Abnormality of the astrocytes (HP:0100707)2.72085088
31Astrocytoma (HP:0009592)2.72085088
32Abnormality of methionine metabolism (HP:0010901)2.67938537
33Pallor (HP:0000980)2.67893922
34Absent thumb (HP:0009777)2.65097885
35Lipid accumulation in hepatocytes (HP:0006561)2.64641731
36Acute necrotizing encephalopathy (HP:0006965)2.63940149
37Impulsivity (HP:0100710)2.59811520
38Aplastic anemia (HP:0001915)2.57460594
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56695354
40Abnormality of alanine metabolism (HP:0010916)2.56695354
41Hyperalaninemia (HP:0003348)2.56695354
42Abnormal number of incisors (HP:0011064)2.55394917
43Amaurosis fugax (HP:0100576)2.55244470
44Abnormality of serum amino acid levels (HP:0003112)2.49205793
45Aplasia/Hypoplasia of the patella (HP:0006498)2.46992445
46Abnormality of the preputium (HP:0100587)2.46735780
47Glioma (HP:0009733)2.45918697
48Absent radius (HP:0003974)2.42387588
49Biliary tract neoplasm (HP:0100574)2.41108354
50Acute encephalopathy (HP:0006846)2.41081397
51Increased nuchal translucency (HP:0010880)2.40899517
52Meckel diverticulum (HP:0002245)2.36091910
53Rough bone trabeculation (HP:0100670)2.34994953
54Carpal bone hypoplasia (HP:0001498)2.33707902
55Neoplasm of the pancreas (HP:0002894)2.32249938
56Supernumerary spleens (HP:0009799)2.31920539
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29639127
58Thrombocytosis (HP:0001894)2.28454664
59Absent forearm bone (HP:0003953)2.27671183
60Aplasia involving forearm bones (HP:0009822)2.27671183
61Atresia of the external auditory canal (HP:0000413)2.26846999
62Abnormality of the ileum (HP:0001549)2.26480784
63Abnormal mitochondria in muscle tissue (HP:0008316)2.26452679
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.23199521
65Methylmalonic acidemia (HP:0002912)2.22404236
66Ectopic kidney (HP:0000086)2.20558058
67Prominent nose (HP:0000448)2.19792900
68Missing ribs (HP:0000921)2.19594464
69Microvesicular hepatic steatosis (HP:0001414)2.19122348
70Megaloblastic anemia (HP:0001889)2.17665717
71Cerebral edema (HP:0002181)2.16338458
7211 pairs of ribs (HP:0000878)2.15843183
73Acute myeloid leukemia (HP:0004808)2.15594293
74Progressive macrocephaly (HP:0004481)2.15304344
75Spastic diplegia (HP:0001264)2.14681543
76Sparse lateral eyebrow (HP:0005338)2.14395609
77Hypoglycemic seizures (HP:0002173)2.11893753
78Premature graying of hair (HP:0002216)2.11164416
79Sloping forehead (HP:0000340)2.10625141
80Cerebral hypomyelination (HP:0006808)2.09807393
81Squamous cell carcinoma (HP:0002860)2.09254920
82Glossoptosis (HP:0000162)2.07813944
83Small intestinal stenosis (HP:0012848)2.06867108
84Duodenal stenosis (HP:0100867)2.06867108
85Embryonal neoplasm (HP:0002898)2.05905006
86Abnormal lung lobation (HP:0002101)2.05867319
87Aplasia/Hypoplasia of the sternum (HP:0006714)2.05010704
88Stenosis of the external auditory canal (HP:0000402)2.04907397
89Reduced antithrombin III activity (HP:0001976)2.04582609
90Facial hemangioma (HP:0000329)2.04440678
91Neoplasm of the colon (HP:0100273)2.04143597
92Increased CSF lactate (HP:0002490)2.03702663
93Progressive external ophthalmoplegia (HP:0000590)2.03477002
94Lymphoma (HP:0002665)2.03243181
95IgM deficiency (HP:0002850)2.01496742
96Hyperglycinemia (HP:0002154)1.97707750
97Septo-optic dysplasia (HP:0100842)1.96152194
98Pancreatic islet-cell hyperplasia (HP:0004510)1.96060593
99Horseshoe kidney (HP:0000085)1.95890035
100Overlapping toe (HP:0001845)1.95656285
101Supernumerary bones of the axial skeleton (HP:0009144)1.94770674
102Homocystinuria (HP:0002156)1.94427988
103Abnormality of homocysteine metabolism (HP:0010919)1.94427988
104Hypoplasia of the pons (HP:0012110)1.93584639
105Breast carcinoma (HP:0003002)1.92750346
106Cafe-au-lait spot (HP:0000957)1.92508147
107Cortical dysplasia (HP:0002539)1.92421102
108Abnormal hair whorl (HP:0010721)1.92051970
109Abnormality of the duodenum (HP:0002246)1.88203297
110Bone marrow hypocellularity (HP:0005528)1.87805308
111Premature ovarian failure (HP:0008209)1.87073478
112Long eyelashes (HP:0000527)1.86994917
113Type I transferrin isoform profile (HP:0003642)1.86939599
114Supernumerary ribs (HP:0005815)1.86697493
115Pancytopenia (HP:0001876)1.85886644
116Aplasia/hypoplasia of the humerus (HP:0006507)1.85690034
117Intestinal atresia (HP:0011100)1.85596259
118Abnormal trabecular bone morphology (HP:0100671)1.85480726
119Abnormality of the pons (HP:0007361)1.85184626
120Gastrointestinal atresia (HP:0002589)1.84893063
121Rectal fistula (HP:0100590)1.84537273
122Rectovaginal fistula (HP:0000143)1.84537273
123Hyperinsulinemic hypoglycemia (HP:0000825)1.83334818
124Increased serum lactate (HP:0002151)1.82200122
125Cellular immunodeficiency (HP:0005374)1.81870568
126Clitoromegaly (HP:0000057)1.81616383
127Neoplasm of the small intestine (HP:0100833)1.80975397
128Abnormality of DNA repair (HP:0003254)1.80720556
129Progressive muscle weakness (HP:0003323)1.79172399
130Abnormality of pyrimidine metabolism (HP:0004353)1.79062720
131Ovarian neoplasm (HP:0100615)1.77071141
132Short thumb (HP:0009778)1.75522273
133Neoplasm of the rectum (HP:0100743)1.75336081
134Facial cleft (HP:0002006)1.74868695
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.74766598
136Hepatoblastoma (HP:0002884)1.74680305
137Increased serum pyruvate (HP:0003542)1.74611093
138Nephroblastoma (Wilms tumor) (HP:0002667)1.73213396
139High pitched voice (HP:0001620)1.72431244
140Leukodystrophy (HP:0002415)1.72378676
141Mitochondrial inheritance (HP:0001427)1.71794094
142Asplenia (HP:0001746)1.71589734
143Abnormality of the septum pellucidum (HP:0007375)1.71392523
144Tracheoesophageal fistula (HP:0002575)1.71360806
145Low anterior hairline (HP:0000294)1.71052358
146Rib fusion (HP:0000902)1.71038012
147Triphalangeal thumb (HP:0001199)1.70903836
148Multiple enchondromatosis (HP:0005701)1.70209519
149Uterine neoplasm (HP:0010784)1.68647401
150Hypoglycemic coma (HP:0001325)1.68536098
151Esophageal atresia (HP:0002032)1.66941646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.53435004
2WEE14.18190094
3BUB13.12330407
4CDK123.01625058
5SRPK12.81815395
6NEK22.77793444
7TSSK62.68372791
8EIF2AK12.57730887
9MKNK12.36808737
10ACVR1B2.33922286
11TTK2.17853756
12RPS6KB22.14447388
13TAF12.14182668
14VRK22.09769052
15PASK2.06656743
16PLK11.96422112
17MKNK21.88417886
18TLK11.87032443
19PLK31.80124621
20CDK71.78401955
21BRSK21.78366261
22ATR1.74236044
23PNCK1.73421756
24PLK41.72498390
25EEF2K1.69825107
26VRK11.68335113
27AURKB1.67428708
28EIF2AK31.63884284
29STK101.62809522
30BRD41.61464124
31DYRK31.57824182
32NUAK11.55134965
33RPS6KA41.54661948
34NME21.53368342
35CDK41.51635959
36CHEK11.50278577
37CHEK21.46349345
38STK38L1.35314114
39MAP3K81.33714052
40TGFBR11.33466878
41STK391.27291763
42WNK31.26074262
43FLT31.23074415
44CDK61.21186560
45ATM1.15621335
46TNIK1.14283525
47NME11.13752405
48EPHA21.12251645
49ALK1.11887961
50NEK11.11540124
51TRIM281.09758974
52ERBB41.06889950
53MAP4K11.06535359
54CDK21.04633780
55MAP2K31.00264225
56MAP3K100.96104819
57CSNK2A20.94961477
58AURKA0.94386841
59MELK0.93748688
60PIM10.93643306
61WNK40.92127977
62STK160.90917461
63OXSR10.90383182
64SCYL20.90067231
65PDK20.88853314
66STK40.87419729
67PAK40.86989013
68BMPR1B0.84633033
69RPS6KA50.81601614
70PKN20.80899634
71CDK190.78475471
72CDK10.78464390
73MST40.76358796
74TESK20.74977465
75STK30.74099572
76ERBB30.72577254
77CSNK1E0.69409789
78CDK30.69115116
79CSNK2A10.66833734
80LRRK20.65247878
81MTOR0.63970307
82PLK20.63335979
83BRAF0.62449605
84TEC0.61803787
85CDK90.58426950
86BTK0.57053678
87STK240.54653039
88BRSK10.54416862
89CSNK1D0.52556698
90PAK20.52493680
91BCR0.51386855
92PRKDC0.50958466
93CSF1R0.49921918
94LATS10.48072050
95DYRK20.45677833
96CSNK1G20.44733176
97CDK80.44664971
98GRK60.44001816
99MET0.42283661
100EIF2AK20.42013574
101MAPK140.41962136
102CCNB10.39944769
103NEK90.39015444
104ZAP700.38952934
105CLK10.38534069
106PIM20.38174853
107MAP3K120.37138701
108LATS20.36377780
109PAK10.36269145
110ZAK0.35797478
111ITK0.35008092
112AKT20.32659226
113PBK0.32463433
114PRKCI0.31677913
115FGFR10.31019780
116MAPK10.30934922
117NEK60.29886503
118JAK30.29852282
119NLK0.29187221
120CSNK1G10.28619262
121TAOK20.28033401
122LCK0.27572301
123AKT10.27014462
124MAP3K60.26446282
125CSNK1G30.26168868
126GSK3B0.25941342
127BMPR20.23807555
128CSNK1A1L0.22944655
129SMG10.18943430

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35760559
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28943077
3Mismatch repair_Homo sapiens_hsa034304.12283021
4Ribosome_Homo sapiens_hsa030103.63883519
5Spliceosome_Homo sapiens_hsa030403.61376157
6RNA transport_Homo sapiens_hsa030133.49932839
7One carbon pool by folate_Homo sapiens_hsa006703.16833426
8RNA polymerase_Homo sapiens_hsa030203.13197568
9Nucleotide excision repair_Homo sapiens_hsa034202.86459614
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71498997
11Homologous recombination_Homo sapiens_hsa034402.70315101
12Cell cycle_Homo sapiens_hsa041102.62524006
13Base excision repair_Homo sapiens_hsa034102.60628287
14Non-homologous end-joining_Homo sapiens_hsa034502.45315689
15Proteasome_Homo sapiens_hsa030502.40197965
16Basal transcription factors_Homo sapiens_hsa030222.19128868
17RNA degradation_Homo sapiens_hsa030182.19080710
18Fanconi anemia pathway_Homo sapiens_hsa034602.16360029
19mRNA surveillance pathway_Homo sapiens_hsa030152.14461348
20Pyrimidine metabolism_Homo sapiens_hsa002402.11758118
21Oxidative phosphorylation_Homo sapiens_hsa001901.60254279
22Parkinsons disease_Homo sapiens_hsa050121.51531517
23Systemic lupus erythematosus_Homo sapiens_hsa053221.46854089
24p53 signaling pathway_Homo sapiens_hsa041151.44280779
25Propanoate metabolism_Homo sapiens_hsa006401.27310465
26Epstein-Barr virus infection_Homo sapiens_hsa051691.23875316
27Huntingtons disease_Homo sapiens_hsa050161.22876198
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21728253
29Steroid biosynthesis_Homo sapiens_hsa001001.16865029
30Pyruvate metabolism_Homo sapiens_hsa006201.15496105
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08320773
32Viral carcinogenesis_Homo sapiens_hsa052031.07053959
33Antigen processing and presentation_Homo sapiens_hsa046121.05726026
34Selenocompound metabolism_Homo sapiens_hsa004501.03235094
35Purine metabolism_Homo sapiens_hsa002301.02461542
36Herpes simplex infection_Homo sapiens_hsa051680.98856200
37Vitamin B6 metabolism_Homo sapiens_hsa007500.92390393
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.88726095
39Folate biosynthesis_Homo sapiens_hsa007900.88077785
40Alzheimers disease_Homo sapiens_hsa050100.85700656
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.84444035
42Sulfur relay system_Homo sapiens_hsa041220.83575912
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82831545
44Oocyte meiosis_Homo sapiens_hsa041140.80751566
45Biosynthesis of amino acids_Homo sapiens_hsa012300.79923900
46MicroRNAs in cancer_Homo sapiens_hsa052060.78374966
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77678787
48HTLV-I infection_Homo sapiens_hsa051660.73942564
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73370096
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70628486
51Thyroid cancer_Homo sapiens_hsa052160.70171871
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69418414
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.68210407
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66366817
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64440477
56Small cell lung cancer_Homo sapiens_hsa052220.62214650
57Primary immunodeficiency_Homo sapiens_hsa053400.61298654
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60324563
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59797439
60Fatty acid elongation_Homo sapiens_hsa000620.57144373
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55476331
62Protein export_Homo sapiens_hsa030600.54518880
63TGF-beta signaling pathway_Homo sapiens_hsa043500.53899969
64Lysine degradation_Homo sapiens_hsa003100.49603066
65Pentose phosphate pathway_Homo sapiens_hsa000300.48129842
66Colorectal cancer_Homo sapiens_hsa052100.47547579
67Alcoholism_Homo sapiens_hsa050340.47216867
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.44723085
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44051066
70Vitamin digestion and absorption_Homo sapiens_hsa049770.41716269
71Chronic myeloid leukemia_Homo sapiens_hsa052200.41222071
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41151588
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41095609
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38160737
75Cardiac muscle contraction_Homo sapiens_hsa042600.37630666
76Legionellosis_Homo sapiens_hsa051340.35800047
77Measles_Homo sapiens_hsa051620.35282244
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34820439
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33579802
80Hepatitis B_Homo sapiens_hsa051610.32946043
81Basal cell carcinoma_Homo sapiens_hsa052170.32828692
82Hippo signaling pathway_Homo sapiens_hsa043900.31835716
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30887228
84Apoptosis_Homo sapiens_hsa042100.30596005
85Notch signaling pathway_Homo sapiens_hsa043300.30593179
86Prostate cancer_Homo sapiens_hsa052150.30219371
87T cell receptor signaling pathway_Homo sapiens_hsa046600.30131257
88Glutathione metabolism_Homo sapiens_hsa004800.29717674
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.29335502
90Acute myeloid leukemia_Homo sapiens_hsa052210.27565015
91Pathways in cancer_Homo sapiens_hsa052000.26562668
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26413301
93Hematopoietic cell lineage_Homo sapiens_hsa046400.26301582
94Regulation of autophagy_Homo sapiens_hsa041400.23827138
95B cell receptor signaling pathway_Homo sapiens_hsa046620.21915455
96Carbon metabolism_Homo sapiens_hsa012000.21854377
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20836267
98Allograft rejection_Homo sapiens_hsa053300.20492740
99Tight junction_Homo sapiens_hsa045300.20379718
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19591653
101Adherens junction_Homo sapiens_hsa045200.18700098
102Fatty acid metabolism_Homo sapiens_hsa012120.17999655
103mTOR signaling pathway_Homo sapiens_hsa041500.17390319
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17116524
105Arginine and proline metabolism_Homo sapiens_hsa003300.16761826
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.16584585
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.16264604
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16200576
109Retinol metabolism_Homo sapiens_hsa008300.15803338
110Fatty acid degradation_Homo sapiens_hsa000710.15131589
111Wnt signaling pathway_Homo sapiens_hsa043100.14996732
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14784783
113Influenza A_Homo sapiens_hsa051640.14767280
114Pancreatic cancer_Homo sapiens_hsa052120.14484319
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14482305
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14456597
117Shigellosis_Homo sapiens_hsa051310.14360972
118Non-small cell lung cancer_Homo sapiens_hsa052230.13835300
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13078450
120N-Glycan biosynthesis_Homo sapiens_hsa005100.12219770
121Melanoma_Homo sapiens_hsa052180.12043948
122Butanoate metabolism_Homo sapiens_hsa006500.11066008
123Circadian rhythm_Homo sapiens_hsa047100.10304054
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09738679
125Hedgehog signaling pathway_Homo sapiens_hsa043400.09605607
126Bladder cancer_Homo sapiens_hsa052190.09047376
127HIF-1 signaling pathway_Homo sapiens_hsa040660.09010946
128Metabolic pathways_Homo sapiens_hsa011000.08288061
129FoxO signaling pathway_Homo sapiens_hsa040680.07752677
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.07151732
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06502687
132Ether lipid metabolism_Homo sapiens_hsa005650.05670669
133Peroxisome_Homo sapiens_hsa041460.04687022
134Caffeine metabolism_Homo sapiens_hsa002320.04648087
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.04194858

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