

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 8.39516341 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.96877375 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 7.96877375 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 7.57190713 |
| 5 | respiratory electron transport chain (GO:0022904) | 6.73228180 |
| 6 | electron transport chain (GO:0022900) | 6.56086252 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.03961898 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 5.54621278 |
| 9 | protein neddylation (GO:0045116) | 5.34155561 |
| 10 | behavioral response to nicotine (GO:0035095) | 5.27062264 |
| 11 | protein complex biogenesis (GO:0070271) | 5.22210373 |
| 12 | ribosomal small subunit biogenesis (GO:0042274) | 4.98049832 |
| 13 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.97449152 |
| 14 | NADH dehydrogenase complex assembly (GO:0010257) | 4.97449152 |
| 15 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.97449152 |
| 16 | proteasome assembly (GO:0043248) | 4.79414754 |
| 17 | GTP biosynthetic process (GO:0006183) | 4.77865017 |
| 18 | viral transcription (GO:0019083) | 4.76953617 |
| 19 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.75412419 |
| 20 | translational termination (GO:0006415) | 4.60532508 |
| 21 | cotranslational protein targeting to membrane (GO:0006613) | 4.50867984 |
| 22 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.42719958 |
| 23 | protein targeting to ER (GO:0045047) | 4.40643039 |
| 24 | ribosomal small subunit assembly (GO:0000028) | 4.40481612 |
| 25 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.34105942 |
| 26 | termination of RNA polymerase III transcription (GO:0006386) | 4.34105942 |
| 27 | oxidative phosphorylation (GO:0006119) | 4.29538276 |
| 28 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.29278749 |
| 29 | regulation of mitochondrial translation (GO:0070129) | 4.25839190 |
| 30 | protein localization to endoplasmic reticulum (GO:0070972) | 4.25806274 |
| 31 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.22522782 |
| 32 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.21798036 |
| 33 | inner mitochondrial membrane organization (GO:0007007) | 4.19931197 |
| 34 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.17969071 |
| 35 | ATP biosynthetic process (GO:0006754) | 4.15396959 |
| 36 | regulation of posttranscriptional gene silencing (GO:0060147) | 4.15383986 |
| 37 | regulation of gene silencing by miRNA (GO:0060964) | 4.15383986 |
| 38 | regulation of gene silencing by RNA (GO:0060966) | 4.15383986 |
| 39 | hydrogen ion transmembrane transport (GO:1902600) | 4.13530497 |
| 40 | dopamine transport (GO:0015872) | 4.05162848 |
| 41 | UTP biosynthetic process (GO:0006228) | 4.05069013 |
| 42 | cullin deneddylation (GO:0010388) | 3.97225406 |
| 43 | maturation of SSU-rRNA (GO:0030490) | 3.91944624 |
| 44 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.91128542 |
| 45 | establishment of protein localization to mitochondrion (GO:0072655) | 3.88419857 |
| 46 | translational elongation (GO:0006414) | 3.88369349 |
| 47 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.87996182 |
| 48 | translation (GO:0006412) | 3.85949298 |
| 49 | protein targeting to mitochondrion (GO:0006626) | 3.83132276 |
| 50 | ribosomal large subunit biogenesis (GO:0042273) | 3.81188005 |
| 51 | respiratory chain complex IV assembly (GO:0008535) | 3.80308072 |
| 52 | cellular protein complex disassembly (GO:0043624) | 3.78201556 |
| 53 | viral life cycle (GO:0019058) | 3.74327283 |
| 54 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.73978862 |
| 55 | 7-methylguanosine mRNA capping (GO:0006370) | 3.69937148 |
| 56 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.69480841 |
| 57 | kynurenine metabolic process (GO:0070189) | 3.69207078 |
| 58 | proton transport (GO:0015992) | 3.67574664 |
| 59 | RNA capping (GO:0036260) | 3.67337439 |
| 60 | 7-methylguanosine RNA capping (GO:0009452) | 3.67337439 |
| 61 | protein deneddylation (GO:0000338) | 3.66199123 |
| 62 | hydrogen transport (GO:0006818) | 3.59028269 |
| 63 | protein localization to mitochondrion (GO:0070585) | 3.58778821 |
| 64 | UTP metabolic process (GO:0046051) | 3.57035258 |
| 65 | L-fucose metabolic process (GO:0042354) | 3.52078006 |
| 66 | L-fucose catabolic process (GO:0042355) | 3.52078006 |
| 67 | fucose catabolic process (GO:0019317) | 3.52078006 |
| 68 | cytochrome complex assembly (GO:0017004) | 3.51863473 |
| 69 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.46095844 |
| 70 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.44678638 |
| 71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.40492427 |
| 72 | peptidyl-histidine modification (GO:0018202) | 3.38054843 |
| 73 | nucleoside diphosphate phosphorylation (GO:0006165) | 3.37817574 |
| 74 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.37440083 |
| 75 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.37440083 |
| 76 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.37313922 |
| 77 | cellular ketone body metabolic process (GO:0046950) | 3.36826314 |
| 78 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.35978216 |
| 79 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.35900646 |
| 80 | negative regulation of ligase activity (GO:0051352) | 3.35900646 |
| 81 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.35072554 |
| 82 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.35072554 |
| 83 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.35072554 |
| 84 | translational initiation (GO:0006413) | 3.33984223 |
| 85 | sulfation (GO:0051923) | 3.31241616 |
| 86 | cellular component biogenesis (GO:0044085) | 3.29105131 |
| 87 | tryptophan catabolic process (GO:0006569) | 3.29057332 |
| 88 | indole-containing compound catabolic process (GO:0042436) | 3.29057332 |
| 89 | indolalkylamine catabolic process (GO:0046218) | 3.29057332 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.26582472 |
| 91 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.26582472 |
| 92 | maturation of 5.8S rRNA (GO:0000460) | 3.25866073 |
| 93 | intracellular protein transmembrane import (GO:0044743) | 3.23275871 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.22685512 |
| 95 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.21881146 |
| 96 | CTP metabolic process (GO:0046036) | 3.20210040 |
| 97 | CTP biosynthetic process (GO:0006241) | 3.20210040 |
| 98 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.18989905 |
| 99 | establishment of integrated proviral latency (GO:0075713) | 3.18740632 |
| 100 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.18355557 |
| 101 | regulation of cellular amine metabolic process (GO:0033238) | 3.17685983 |
| 102 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.17549335 |
| 103 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.12375582 |
| 104 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.10198185 |
| 105 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.10198185 |
| 106 | establishment of viral latency (GO:0019043) | 3.09778684 |
| 107 | indolalkylamine metabolic process (GO:0006586) | 3.08427369 |
| 108 | mitochondrial transport (GO:0006839) | 3.06859924 |
| 109 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.05564734 |
| 110 | protein-cofactor linkage (GO:0018065) | 3.03689369 |
| 111 | cellular response to ATP (GO:0071318) | 3.03482060 |
| 112 | protein complex disassembly (GO:0043241) | 3.02285337 |
| 113 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.02098083 |
| 114 | rRNA modification (GO:0000154) | 3.01245598 |
| 115 | gamma-aminobutyric acid transport (GO:0015812) | 3.00524025 |
| 116 | aerobic respiration (GO:0009060) | 2.99766118 |
| 117 | kidney morphogenesis (GO:0060993) | 2.99357594 |
| 118 | regulation of oxidative phosphorylation (GO:0002082) | 2.97668982 |
| 119 | regulation of hexokinase activity (GO:1903299) | 2.97393788 |
| 120 | regulation of glucokinase activity (GO:0033131) | 2.97393788 |
| 121 | macromolecular complex disassembly (GO:0032984) | 2.96468197 |
| 122 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.95532534 |
| 123 | transcription from RNA polymerase I promoter (GO:0006360) | 2.89268725 |
| 124 | DNA deamination (GO:0045006) | 2.87909840 |
| 125 | response to pheromone (GO:0019236) | 2.87850336 |
| 126 | pseudouridine synthesis (GO:0001522) | 2.87807816 |
| 127 | ketone body metabolic process (GO:1902224) | 2.80800841 |
| 128 | nephron epithelium morphogenesis (GO:0072088) | 2.78920567 |
| 129 | nephron tubule morphogenesis (GO:0072078) | 2.78920567 |
| 130 | regulation of hippo signaling (GO:0035330) | 2.78714924 |
| 131 | negative regulation of telomere maintenance (GO:0032205) | 2.78064814 |
| 132 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.73880490 |
| 133 | regulation of action potential (GO:0098900) | 2.72144090 |
| 134 | tryptophan metabolic process (GO:0006568) | 2.69588446 |
| 135 | protein K6-linked ubiquitination (GO:0085020) | 2.67040777 |
| 136 | protein prenylation (GO:0018342) | 2.60455213 |
| 137 | prenylation (GO:0097354) | 2.60455213 |
| 138 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.58450221 |
| 139 | primary amino compound metabolic process (GO:1901160) | 2.57799790 |
| 140 | neuronal action potential (GO:0019228) | 2.56408334 |
| 141 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 2.56034437 |
| 142 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 2.56034437 |
| 143 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.54201186 |
| 144 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.54201186 |
| 145 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.54201186 |
| 146 | regulation of DNA endoreduplication (GO:0032875) | 2.50131894 |
| 147 | indole-containing compound metabolic process (GO:0042430) | 2.49936003 |
| 148 | reflex (GO:0060004) | 2.48113245 |
| 149 | serotonin metabolic process (GO:0042428) | 2.47479614 |
| 150 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.46180490 |
| 151 | detection of light stimulus involved in visual perception (GO:0050908) | 2.46180490 |
| 152 | regulation of skeletal muscle contraction (GO:0014819) | 2.45815961 |
| 153 | regulation of sequestering of triglyceride (GO:0010889) | 2.45703440 |
| 154 | platelet dense granule organization (GO:0060155) | 2.45406483 |
| 155 | membrane depolarization during action potential (GO:0086010) | 2.44957631 |
| 156 | protein import into peroxisome matrix (GO:0016558) | 2.44530633 |
| 157 | rRNA catabolic process (GO:0016075) | 2.43900333 |
| 158 | magnesium ion transport (GO:0015693) | 2.35290153 |
| 159 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.35204223 |
| 160 | amino acid salvage (GO:0043102) | 2.34866900 |
| 161 | L-methionine salvage (GO:0071267) | 2.34866900 |
| 162 | L-methionine biosynthetic process (GO:0071265) | 2.34866900 |
| 163 | positive regulation of action potential (GO:0045760) | 2.31867913 |
| 164 | calcium ion import (GO:0070509) | 2.30671473 |
| 165 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.29263727 |
| 166 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.27688892 |
| 167 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.27444218 |
| 168 | negative regulation of response to food (GO:0032096) | 2.27284341 |
| 169 | negative regulation of appetite (GO:0032099) | 2.27284341 |
| 170 | double-strand break repair via homologous recombination (GO:0000724) | 2.26802891 |
| 171 | recombinational repair (GO:0000725) | 2.26309971 |
| 172 | regulation of triglyceride biosynthetic process (GO:0010866) | 2.26308974 |
| 173 | positive regulation of fatty acid oxidation (GO:0046321) | 2.25977641 |
| 174 | replication fork processing (GO:0031297) | 2.25859859 |
| 175 | methionine biosynthetic process (GO:0009086) | 2.21734034 |
| 176 | piRNA metabolic process (GO:0034587) | 2.21419135 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.96166623 |
| 2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.41000772 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.37620665 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.14637919 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.11273986 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.77656181 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.63028414 |
| 8 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.37614081 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.34179792 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.30514022 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.29204943 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.25334761 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.24150866 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.15947403 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.92241298 |
| 16 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.60048572 |
| 17 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.47442072 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.43213587 |
| 19 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.38466399 |
| 20 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.36364346 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.35885554 |
| 22 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30619228 |
| 23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.27440696 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.24794691 |
| 25 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.21410716 |
| 26 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.14530678 |
| 27 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.13135880 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.11556127 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.08626121 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.00654343 |
| 31 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.99304113 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.97944490 |
| 33 | VDR_22108803_ChIP-Seq_LS180_Human | 1.90990272 |
| 34 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.79164371 |
| 35 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.76514576 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.75575886 |
| 37 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.73737113 |
| 38 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.63539935 |
| 39 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.62358652 |
| 40 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.61294422 |
| 41 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.59714208 |
| 42 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.57198615 |
| 43 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.57135720 |
| 44 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.54196319 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54039324 |
| 46 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.53406295 |
| 47 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.50239785 |
| 48 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.49346662 |
| 49 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.48126820 |
| 50 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.47235117 |
| 51 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.47235117 |
| 52 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.45697868 |
| 53 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.43998353 |
| 54 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.43760782 |
| 55 | FUS_26573619_Chip-Seq_HEK293_Human | 1.41377716 |
| 56 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.38609316 |
| 57 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.38252772 |
| 58 | STAT3_23295773_ChIP-Seq_U87_Human | 1.36687789 |
| 59 | TCF4_23295773_ChIP-Seq_U87_Human | 1.36432163 |
| 60 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.36090375 |
| 61 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.35760552 |
| 62 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.35760552 |
| 63 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.35405678 |
| 64 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.33128765 |
| 65 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.32791793 |
| 66 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.32791793 |
| 67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.29712230 |
| 68 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.29291701 |
| 69 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.28610678 |
| 70 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.26988101 |
| 71 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.25876897 |
| 72 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.23584811 |
| 73 | AR_25329375_ChIP-Seq_VCAP_Human | 1.22996323 |
| 74 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22913685 |
| 75 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.21934850 |
| 76 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.21658201 |
| 77 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.19888732 |
| 78 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.19605340 |
| 79 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.18221648 |
| 80 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.17926250 |
| 81 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.17807205 |
| 82 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.17637012 |
| 83 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.17345138 |
| 84 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.16899804 |
| 85 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.16793958 |
| 86 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.16489388 |
| 87 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.16425059 |
| 88 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.15589544 |
| 89 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.15314350 |
| 90 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.15226951 |
| 91 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.14469028 |
| 92 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.14273909 |
| 93 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.13308975 |
| 94 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.12983280 |
| 95 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.12090130 |
| 96 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.11156970 |
| 97 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.09759009 |
| 98 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.09631037 |
| 99 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.09349542 |
| 100 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.09349542 |
| 101 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.09349542 |
| 102 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.08765966 |
| 103 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.08225753 |
| 104 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.06999555 |
| 105 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.06482390 |
| 106 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.06017426 |
| 107 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05602420 |
| 108 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.05302173 |
| 109 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.05291616 |
| 110 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.04897029 |
| 111 | AR_20517297_ChIP-Seq_VCAP_Human | 1.04703593 |
| 112 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.03867633 |
| 113 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.03622801 |
| 114 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.03162581 |
| 115 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02034224 |
| 116 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.01557436 |
| 117 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.01520583 |
| 118 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.01185534 |
| 119 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.01024407 |
| 120 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.00918835 |
| 121 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.00602733 |
| 122 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.00377825 |
| 123 | JUN_21703547_ChIP-Seq_K562_Human | 1.00342904 |
| 124 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.00168478 |
| 125 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99678442 |
| 126 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.99678442 |
| 127 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.99510584 |
| 128 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.99430707 |
| 129 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.99094592 |
| 130 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.98380560 |
| 131 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.98092168 |
| 132 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.97107909 |
| 133 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.96938970 |
| 134 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95802002 |
| 135 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.93053731 |
| 136 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.91438221 |
| 137 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91141057 |
| 138 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.90667613 |
| 139 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90405961 |
| 140 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.90050706 |
| 141 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.89964706 |
| 142 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.89717453 |
| 143 | EWS_26573619_Chip-Seq_HEK293_Human | 0.89716092 |
| 144 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.87087060 |
| 145 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.85464858 |
| 146 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.83989102 |
| 147 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.83416560 |
| 148 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.82791998 |
| 149 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.82332315 |
| 150 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.81516835 |
| 151 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.80741704 |
| 152 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80279970 |
| 153 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.78892580 |
| 154 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.78763355 |
| 155 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.77861025 |
| 156 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.76723131 |
| 157 | P300_19829295_ChIP-Seq_ESCs_Human | 0.76631772 |
| 158 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.76563782 |
| 159 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.76412078 |
| 160 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.75742323 |
| 161 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.75733467 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 4.77511128 |
| 2 | MP0001529_abnormal_vocalization | 4.19211007 |
| 3 | MP0003880_abnormal_central_pattern | 3.87251730 |
| 4 | MP0001905_abnormal_dopamine_level | 3.49403398 |
| 5 | MP0006276_abnormal_autonomic_nervous | 3.06767113 |
| 6 | MP0003136_yellow_coat_color | 2.82475811 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.70802034 |
| 8 | MP0001986_abnormal_taste_sensitivity | 2.60449593 |
| 9 | MP0001188_hyperpigmentation | 2.47999708 |
| 10 | MP0003646_muscle_fatigue | 2.45317668 |
| 11 | MP0006035_abnormal_mitochondrial_morpho | 2.33841010 |
| 12 | MP0002736_abnormal_nociception_after | 2.32563463 |
| 13 | MP0004142_abnormal_muscle_tone | 2.26560967 |
| 14 | MP0006036_abnormal_mitochondrial_physio | 2.16417996 |
| 15 | MP0001968_abnormal_touch/_nociception | 2.12333693 |
| 16 | MP0003186_abnormal_redox_activity | 2.10549219 |
| 17 | MP0004215_abnormal_myocardial_fiber | 2.01373978 |
| 18 | MP0003806_abnormal_nucleotide_metabolis | 1.99179144 |
| 19 | MP0000372_irregular_coat_pigmentation | 1.92502314 |
| 20 | MP0002638_abnormal_pupillary_reflex | 1.90647617 |
| 21 | MP0002735_abnormal_chemical_nociception | 1.90066236 |
| 22 | MP0003718_maternal_effect | 1.86377816 |
| 23 | MP0000569_abnormal_digit_pigmentation | 1.84487182 |
| 24 | MP0004043_abnormal_pH_regulation | 1.83138283 |
| 25 | MP0005171_absent_coat_pigmentation | 1.81884809 |
| 26 | MP0010386_abnormal_urinary_bladder | 1.81355687 |
| 27 | MP0002734_abnormal_mechanical_nocicepti | 1.78801709 |
| 28 | MP0009697_abnormal_copulation | 1.71049575 |
| 29 | MP0005645_abnormal_hypothalamus_physiol | 1.70070077 |
| 30 | MP0001440_abnormal_grooming_behavior | 1.68834774 |
| 31 | MP0009780_abnormal_chondrocyte_physiolo | 1.65660096 |
| 32 | MP0002272_abnormal_nervous_system | 1.61991695 |
| 33 | MP0003941_abnormal_skin_development | 1.60738049 |
| 34 | MP0005408_hypopigmentation | 1.60055190 |
| 35 | MP0009046_muscle_twitch | 1.58106298 |
| 36 | MP0001970_abnormal_pain_threshold | 1.55366428 |
| 37 | MP0002837_dystrophic_cardiac_calcinosis | 1.53710479 |
| 38 | MP0009745_abnormal_behavioral_response | 1.52914922 |
| 39 | MP0002064_seizures | 1.51226135 |
| 40 | MP0004147_increased_porphyrin_level | 1.50132733 |
| 41 | MP0002163_abnormal_gland_morphology | 1.48768884 |
| 42 | MP0005379_endocrine/exocrine_gland_phen | 1.46728920 |
| 43 | MP0002733_abnormal_thermal_nociception | 1.43459798 |
| 44 | MP0001984_abnormal_olfaction | 1.43072214 |
| 45 | MP0006072_abnormal_retinal_apoptosis | 1.42146850 |
| 46 | MP0002822_catalepsy | 1.41511873 |
| 47 | MP0005389_reproductive_system_phenotype | 1.40565059 |
| 48 | MP0004145_abnormal_muscle_electrophysio | 1.40298826 |
| 49 | MP0006292_abnormal_olfactory_placode | 1.37992524 |
| 50 | MP0004885_abnormal_endolymph | 1.37974278 |
| 51 | MP0002751_abnormal_autonomic_nervous | 1.37665196 |
| 52 | MP0005332_abnormal_amino_acid | 1.36078426 |
| 53 | MP0002132_abnormal_respiratory_system | 1.33533223 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.32697432 |
| 55 | MP0005386_behavior/neurological_phenoty | 1.31938268 |
| 56 | MP0004924_abnormal_behavior | 1.31938268 |
| 57 | MP0008932_abnormal_embryonic_tissue | 1.31221446 |
| 58 | MP0002572_abnormal_emotion/affect_behav | 1.30364344 |
| 59 | MP0003787_abnormal_imprinting | 1.30046883 |
| 60 | MP0002254_reproductive_system_inflammat | 1.29226748 |
| 61 | MP0008775_abnormal_heart_ventricle | 1.29006953 |
| 62 | MP0002876_abnormal_thyroid_physiology | 1.28710840 |
| 63 | MP0005423_abnormal_somatic_nervous | 1.28482351 |
| 64 | MP0004957_abnormal_blastocyst_morpholog | 1.26005197 |
| 65 | MP0008875_abnormal_xenobiotic_pharmacok | 1.24212166 |
| 66 | MP0005409_darkened_coat_color | 1.24029753 |
| 67 | MP0004381_abnormal_hair_follicle | 1.23812941 |
| 68 | MP0002067_abnormal_sensory_capabilities | 1.23435953 |
| 69 | MP0004130_abnormal_muscle_cell | 1.23114696 |
| 70 | MP0004270_analgesia | 1.20078145 |
| 71 | MP0002332_abnormal_exercise_endurance | 1.18666003 |
| 72 | MP0004133_heterotaxia | 1.17867588 |
| 73 | MP0001764_abnormal_homeostasis | 1.15242741 |
| 74 | MP0003011_delayed_dark_adaptation | 1.14190605 |
| 75 | MP0003693_abnormal_embryo_hatching | 1.13962144 |
| 76 | MP0003283_abnormal_digestive_organ | 1.11625035 |
| 77 | MP0005551_abnormal_eye_electrophysiolog | 1.10628881 |
| 78 | MP0001919_abnormal_reproductive_system | 1.08546785 |
| 79 | MP0003890_abnormal_embryonic-extraembry | 1.08144150 |
| 80 | MP0005084_abnormal_gallbladder_morpholo | 1.06766529 |
| 81 | MP0010329_abnormal_lipoprotein_level | 1.06002068 |
| 82 | MP0002938_white_spotting | 1.05809446 |
| 83 | MP0005253_abnormal_eye_physiology | 1.02687139 |
| 84 | MP0001501_abnormal_sleep_pattern | 1.01536039 |
| 85 | MP0003786_premature_aging | 1.00973314 |
| 86 | MP0003635_abnormal_synaptic_transmissio | 0.99345181 |
| 87 | MP0003122_maternal_imprinting | 0.99116711 |
| 88 | MP0000230_abnormal_systemic_arterial | 0.97686741 |
| 89 | MP0003137_abnormal_impulse_conducting | 0.97584662 |
| 90 | MP0005075_abnormal_melanosome_morpholog | 0.97574851 |
| 91 | MP0008057_abnormal_DNA_replication | 0.96669799 |
| 92 | MP0003195_calcinosis | 0.96628448 |
| 93 | MP0003315_abnormal_perineum_morphology | 0.95077176 |
| 94 | MP0002693_abnormal_pancreas_physiology | 0.95006618 |
| 95 | MP0003937_abnormal_limbs/digits/tail_de | 0.94531674 |
| 96 | MP0004134_abnormal_chest_morphology | 0.93536116 |
| 97 | MP0000778_abnormal_nervous_system | 0.93379896 |
| 98 | MP0000427_abnormal_hair_cycle | 0.92619854 |
| 99 | MP0008058_abnormal_DNA_repair | 0.92324861 |
| 100 | MP0008872_abnormal_physiological_respon | 0.91689603 |
| 101 | MP0001542_abnormal_bone_strength | 0.91678206 |
| 102 | MP0001486_abnormal_startle_reflex | 0.91376403 |
| 103 | MP0002277_abnormal_respiratory_mucosa | 0.91279750 |
| 104 | MP0004019_abnormal_vitamin_homeostasis | 0.91263347 |
| 105 | MP0008995_early_reproductive_senescence | 0.91114473 |
| 106 | MP0002184_abnormal_innervation | 0.90940313 |
| 107 | MP0001944_abnormal_pancreas_morphology | 0.90788749 |
| 108 | MP0004742_abnormal_vestibular_system | 0.90487068 |
| 109 | MP0005266_abnormal_metabolism | 0.89511868 |
| 110 | MP0005174_abnormal_tail_pigmentation | 0.88832575 |
| 111 | MP0001485_abnormal_pinna_reflex | 0.88381274 |
| 112 | MP0004084_abnormal_cardiac_muscle | 0.87438545 |
| 113 | MP0000631_abnormal_neuroendocrine_gland | 0.87044272 |
| 114 | MP0002557_abnormal_social/conspecific_i | 0.86749106 |
| 115 | MP0003724_increased_susceptibility_to | 0.86424980 |
| 116 | MP0000566_synostosis | 0.86372391 |
| 117 | MP0008004_abnormal_stomach_pH | 0.86253228 |
| 118 | MP0001963_abnormal_hearing_physiology | 0.85895736 |
| 119 | MP0005448_abnormal_energy_balance | 0.85002404 |
| 120 | MP0001727_abnormal_embryo_implantation | 0.84998849 |
| 121 | MP0002229_neurodegeneration | 0.83687130 |
| 122 | MP0005410_abnormal_fertilization | 0.82831376 |
| 123 | MP0002148_abnormal_hypersensitivity_rea | 0.82767524 |
| 124 | MP0002063_abnormal_learning/memory/cond | 0.82433139 |
| 125 | MP0004085_abnormal_heartbeat | 0.81961247 |
| 126 | MP0003950_abnormal_plasma_membrane | 0.81888362 |
| 127 | MP0005620_abnormal_muscle_contractility | 0.81784472 |
| 128 | MP0003121_genomic_imprinting | 0.81714715 |
| 129 | MP0005646_abnormal_pituitary_gland | 0.81504222 |
| 130 | MP0008789_abnormal_olfactory_epithelium | 0.81272476 |
| 131 | MP0002102_abnormal_ear_morphology | 0.80761622 |
| 132 | MP0000538_abnormal_urinary_bladder | 0.79251325 |
| 133 | MP0001502_abnormal_circadian_rhythm | 0.78515553 |
| 134 | MP0000026_abnormal_inner_ear | 0.78482212 |
| 135 | MP0002160_abnormal_reproductive_system | 0.78221883 |
| 136 | MP0005636_abnormal_mineral_homeostasis | 0.78011390 |
| 137 | MP0005376_homeostasis/metabolism_phenot | 0.76217600 |
| 138 | MP0002752_abnormal_somatic_nervous | 0.76214869 |
| 139 | MP0001664_abnormal_digestion | 0.76114472 |
| 140 | MP0008260_abnormal_autophagy | 0.75791567 |
| 141 | MP0004036_abnormal_muscle_relaxation | 0.73937563 |
| 142 | MP0002928_abnormal_bile_duct | 0.73612862 |
| 143 | MP0000749_muscle_degeneration | 0.71899355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.88080971 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.22265200 |
| 3 | Mitochondrial inheritance (HP:0001427) | 6.06652794 |
| 4 | Progressive macrocephaly (HP:0004481) | 5.83540462 |
| 5 | Acute encephalopathy (HP:0006846) | 5.55897403 |
| 6 | Increased CSF lactate (HP:0002490) | 5.17236668 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 5.09070891 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.87763566 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 4.47215116 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 4.43787452 |
| 11 | Hepatic necrosis (HP:0002605) | 4.36900876 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.30394949 |
| 13 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.94801711 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.91387538 |
| 15 | Cerebral edema (HP:0002181) | 3.81802079 |
| 16 | Increased intramyocellular lipid droplets (HP:0012240) | 3.77586754 |
| 17 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.71721455 |
| 18 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.71721455 |
| 19 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.70174978 |
| 20 | Exercise intolerance (HP:0003546) | 3.58487147 |
| 21 | Optic disc pallor (HP:0000543) | 3.55521388 |
| 22 | Respiratory failure (HP:0002878) | 3.48997453 |
| 23 | Lactic acidosis (HP:0003128) | 3.45271277 |
| 24 | Exertional dyspnea (HP:0002875) | 3.43735464 |
| 25 | Abnormality of glycolysis (HP:0004366) | 3.43018229 |
| 26 | Increased serum pyruvate (HP:0003542) | 3.43018229 |
| 27 | Congenital stationary night blindness (HP:0007642) | 3.42948782 |
| 28 | Leukodystrophy (HP:0002415) | 3.42247610 |
| 29 | Increased serum lactate (HP:0002151) | 3.38775630 |
| 30 | Abnormality of the renal cortex (HP:0011035) | 3.32120930 |
| 31 | Abnormal number of erythroid precursors (HP:0012131) | 3.28540850 |
| 32 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.20685143 |
| 33 | Abnormality of renal resorption (HP:0011038) | 3.13091176 |
| 34 | Renal cortical cysts (HP:0000803) | 3.12789956 |
| 35 | Increased muscle lipid content (HP:0009058) | 3.04548277 |
| 36 | Nephronophthisis (HP:0000090) | 2.91410823 |
| 37 | Respiratory difficulties (HP:0002880) | 2.90550906 |
| 38 | Abolished electroretinogram (ERG) (HP:0000550) | 2.81831789 |
| 39 | Abnormality of midbrain morphology (HP:0002418) | 2.80316256 |
| 40 | Molar tooth sign on MRI (HP:0002419) | 2.80316256 |
| 41 | Congenital, generalized hypertrichosis (HP:0004540) | 2.79690967 |
| 42 | Gaze-evoked nystagmus (HP:0000640) | 2.79047434 |
| 43 | Macrocytic anemia (HP:0001972) | 2.77315781 |
| 44 | Type II lissencephaly (HP:0007260) | 2.73304627 |
| 45 | Hypothermia (HP:0002045) | 2.69657314 |
| 46 | Parakeratosis (HP:0001036) | 2.63393641 |
| 47 | Genetic anticipation (HP:0003743) | 2.63370601 |
| 48 | Large for gestational age (HP:0001520) | 2.60049526 |
| 49 | Abnormality of the renal medulla (HP:0100957) | 2.58043555 |
| 50 | Pendular nystagmus (HP:0012043) | 2.54614222 |
| 51 | Abnormality of urine glucose concentration (HP:0011016) | 2.51014232 |
| 52 | Glycosuria (HP:0003076) | 2.51014232 |
| 53 | Reticulocytopenia (HP:0001896) | 2.50307907 |
| 54 | Medial flaring of the eyebrow (HP:0010747) | 2.49238424 |
| 55 | Type I transferrin isoform profile (HP:0003642) | 2.47920844 |
| 56 | Furrowed tongue (HP:0000221) | 2.38663164 |
| 57 | Neuroendocrine neoplasm (HP:0100634) | 2.38245930 |
| 58 | Hyperglycinuria (HP:0003108) | 2.36552788 |
| 59 | Progressive cerebellar ataxia (HP:0002073) | 2.34852838 |
| 60 | Broad-based gait (HP:0002136) | 2.32041059 |
| 61 | Hypoplasia of the pons (HP:0012110) | 2.31349959 |
| 62 | Abnormality of secondary sexual hair (HP:0009888) | 2.31213753 |
| 63 | Abnormality of the axillary hair (HP:0100134) | 2.31213753 |
| 64 | Ketoacidosis (HP:0001993) | 2.30204429 |
| 65 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.29917951 |
| 66 | CNS demyelination (HP:0007305) | 2.29279435 |
| 67 | Abnormality of the pons (HP:0007361) | 2.28431444 |
| 68 | Pheochromocytoma (HP:0002666) | 2.28188642 |
| 69 | Hyperphosphaturia (HP:0003109) | 2.27843179 |
| 70 | Cerebral hypomyelination (HP:0006808) | 2.27719219 |
| 71 | Inability to walk (HP:0002540) | 2.26101810 |
| 72 | X-linked dominant inheritance (HP:0001423) | 2.24773665 |
| 73 | Pallor (HP:0000980) | 2.22000616 |
| 74 | Abnormal pupillary function (HP:0007686) | 2.18402990 |
| 75 | Abnormal ciliary motility (HP:0012262) | 2.15279942 |
| 76 | Hyperventilation (HP:0002883) | 2.15233643 |
| 77 | Gait imbalance (HP:0002141) | 2.14465287 |
| 78 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.13520177 |
| 79 | Congenital primary aphakia (HP:0007707) | 2.12959371 |
| 80 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.12319701 |
| 81 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.12319701 |
| 82 | Pancreatic fibrosis (HP:0100732) | 2.11626698 |
| 83 | Abnormal drinking behavior (HP:0030082) | 2.11546819 |
| 84 | Polydipsia (HP:0001959) | 2.11546819 |
| 85 | Clumsiness (HP:0002312) | 2.11291323 |
| 86 | Limb dystonia (HP:0002451) | 2.11062486 |
| 87 | Confusion (HP:0001289) | 2.10821587 |
| 88 | Lethargy (HP:0001254) | 2.08970099 |
| 89 | Decreased circulating renin level (HP:0003351) | 2.08807417 |
| 90 | Emotional lability (HP:0000712) | 2.08597421 |
| 91 | Hypoglycemic coma (HP:0001325) | 2.08152822 |
| 92 | Hyperglycinemia (HP:0002154) | 2.07013881 |
| 93 | Methylmalonic aciduria (HP:0012120) | 2.05623824 |
| 94 | Abnormal hair whorl (HP:0010721) | 2.05473794 |
| 95 | Tubular atrophy (HP:0000092) | 2.05360076 |
| 96 | Attenuation of retinal blood vessels (HP:0007843) | 2.03391148 |
| 97 | Febrile seizures (HP:0002373) | 2.02260586 |
| 98 | Palpitations (HP:0001962) | 2.00353187 |
| 99 | Keratoconus (HP:0000563) | 2.00301119 |
| 100 | Increased corneal curvature (HP:0100692) | 2.00301119 |
| 101 | Cystic liver disease (HP:0006706) | 1.98907339 |
| 102 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.98056731 |
| 103 | Nephrogenic diabetes insipidus (HP:0009806) | 1.97913069 |
| 104 | Conjunctival hamartoma (HP:0100780) | 1.97355526 |
| 105 | Calf muscle hypertrophy (HP:0008981) | 1.96989309 |
| 106 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.96663149 |
| 107 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.95454281 |
| 108 | Progressive inability to walk (HP:0002505) | 1.94346833 |
| 109 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.93210309 |
| 110 | CNS hypomyelination (HP:0003429) | 1.92940283 |
| 111 | True hermaphroditism (HP:0010459) | 1.90760365 |
| 112 | Chronic hepatic failure (HP:0100626) | 1.90303334 |
| 113 | Renal tubular dysfunction (HP:0000124) | 1.89527645 |
| 114 | Ketosis (HP:0001946) | 1.87957857 |
| 115 | Sclerocornea (HP:0000647) | 1.86791962 |
| 116 | Abnormality of glycine metabolism (HP:0010895) | 1.85956365 |
| 117 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.85956365 |
| 118 | Abnormality of vitamin B metabolism (HP:0004340) | 1.85176450 |
| 119 | Hemiparesis (HP:0001269) | 1.84814970 |
| 120 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.84650224 |
| 121 | Male pseudohermaphroditism (HP:0000037) | 1.84272053 |
| 122 | Microvesicular hepatic steatosis (HP:0001414) | 1.82454323 |
| 123 | Methylmalonic acidemia (HP:0002912) | 1.82291242 |
| 124 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.81962051 |
| 125 | Absent/shortened dynein arms (HP:0200106) | 1.81962051 |
| 126 | Optic nerve hypoplasia (HP:0000609) | 1.81595228 |
| 127 | Vaginal atresia (HP:0000148) | 1.81247565 |
| 128 | Cerebellar dysplasia (HP:0007033) | 1.80664120 |
| 129 | Abnormal urine phosphate concentration (HP:0012599) | 1.79952846 |
| 130 | Dialeptic seizures (HP:0011146) | 1.79086896 |
| 131 | Genital tract atresia (HP:0001827) | 1.78920425 |
| 132 | Fair hair (HP:0002286) | 1.77939889 |
| 133 | Abnormality of serum amino acid levels (HP:0003112) | 1.77857124 |
| 134 | Absence seizures (HP:0002121) | 1.76391511 |
| 135 | Metabolic alkalosis (HP:0200114) | 1.75947931 |
| 136 | Birth length less than 3rd percentile (HP:0003561) | 1.75337656 |
| 137 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.75187937 |
| 138 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.74860595 |
| 139 | Concave nail (HP:0001598) | 1.74618440 |
| 140 | Homocystinuria (HP:0002156) | 1.74427998 |
| 141 | Abnormality of homocysteine metabolism (HP:0010919) | 1.74427998 |
| 142 | Abnormality of placental membranes (HP:0011409) | 1.74405989 |
| 143 | Amniotic constriction ring (HP:0009775) | 1.74405989 |
| 144 | Stenosis of the external auditory canal (HP:0000402) | 1.73246504 |
| 145 | Poor suck (HP:0002033) | 1.72051987 |
| 146 | Blindness (HP:0000618) | 1.71581482 |
| 147 | Absent thumb (HP:0009777) | 1.70969958 |
| 148 | Bilateral microphthalmos (HP:0007633) | 1.70918607 |
| 149 | Protruding tongue (HP:0010808) | 1.70300137 |
| 150 | Abnormal protein glycosylation (HP:0012346) | 1.68149275 |
| 151 | Abnormal glycosylation (HP:0012345) | 1.68149275 |
| 152 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.68149275 |
| 153 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.68149275 |
| 154 | Abnormal hemoglobin (HP:0011902) | 1.67762745 |
| 155 | Myokymia (HP:0002411) | 1.67644859 |
| 156 | Pancreatic cysts (HP:0001737) | 1.64327551 |
| 157 | Median cleft lip (HP:0000161) | 1.61499623 |
| 158 | Hypoplasia of the uterus (HP:0000013) | 1.60167990 |
| 159 | Abnormality of alanine metabolism (HP:0010916) | 1.58185147 |
| 160 | Hyperalaninemia (HP:0003348) | 1.58185147 |
| 161 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.58185147 |
| 162 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.57062403 |
| 163 | Delusions (HP:0000746) | 1.53827056 |
| 164 | Progressive external ophthalmoplegia (HP:0000590) | 1.53040565 |
| 165 | Breast hypoplasia (HP:0003187) | 1.52797968 |
| 166 | Patchy hypopigmentation of hair (HP:0011365) | 1.51326532 |
| 167 | Poor coordination (HP:0002370) | 1.50593903 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 5.22436028 |
| 2 | CASK | 3.33595776 |
| 3 | MAP3K12 | 3.22692527 |
| 4 | MST4 | 3.00557308 |
| 5 | NME2 | 2.96554458 |
| 6 | STK16 | 2.92367553 |
| 7 | NME1 | 2.61298104 |
| 8 | PNCK | 2.54186114 |
| 9 | VRK1 | 2.49520948 |
| 10 | PBK | 2.39561777 |
| 11 | BUB1 | 2.30855139 |
| 12 | INSRR | 2.15855485 |
| 13 | MAPKAPK3 | 2.09631005 |
| 14 | ACVR1B | 1.99491396 |
| 15 | GRK5 | 1.98497573 |
| 16 | ARAF | 1.94851805 |
| 17 | EIF2AK1 | 1.88921346 |
| 18 | WEE1 | 1.86406674 |
| 19 | TAOK3 | 1.85033215 |
| 20 | BCR | 1.71840546 |
| 21 | SRPK1 | 1.68512415 |
| 22 | CDK19 | 1.63073522 |
| 23 | DAPK2 | 1.62687754 |
| 24 | MYLK | 1.61766962 |
| 25 | TLK1 | 1.61364065 |
| 26 | MAP4K2 | 1.57572786 |
| 27 | GRK7 | 1.57183886 |
| 28 | BMPR1B | 1.56842706 |
| 29 | STK39 | 1.54804427 |
| 30 | OXSR1 | 1.50257948 |
| 31 | ADRBK2 | 1.48111368 |
| 32 | MUSK | 1.42370605 |
| 33 | EIF2AK3 | 1.40089801 |
| 34 | MAPKAPK5 | 1.39086027 |
| 35 | TNIK | 1.34829036 |
| 36 | LIMK1 | 1.33513622 |
| 37 | PIM2 | 1.33085354 |
| 38 | BMPR2 | 1.32255359 |
| 39 | TSSK6 | 1.28226679 |
| 40 | NLK | 1.22372097 |
| 41 | VRK2 | 1.22263654 |
| 42 | FGFR2 | 1.21625209 |
| 43 | TAF1 | 1.20667555 |
| 44 | AKT3 | 1.19934034 |
| 45 | TGFBR1 | 1.14583312 |
| 46 | DYRK2 | 1.09953842 |
| 47 | IRAK4 | 1.09874236 |
| 48 | CDC7 | 1.09513161 |
| 49 | STK38L | 1.08029685 |
| 50 | PAK3 | 1.07942198 |
| 51 | MAPK15 | 1.06584351 |
| 52 | PLK2 | 1.06397456 |
| 53 | BRAF | 1.06111810 |
| 54 | BRSK2 | 1.02992384 |
| 55 | STK3 | 1.00976820 |
| 56 | MAP2K7 | 0.98760993 |
| 57 | PLK4 | 0.98304893 |
| 58 | ZAK | 0.98255347 |
| 59 | ABL2 | 0.94001308 |
| 60 | IRAK1 | 0.92652137 |
| 61 | IRAK2 | 0.91599037 |
| 62 | IRAK3 | 0.89611665 |
| 63 | PLK3 | 0.89101328 |
| 64 | CSNK1G3 | 0.88959895 |
| 65 | FLT3 | 0.87747707 |
| 66 | TRPM7 | 0.86245866 |
| 67 | AURKA | 0.83879664 |
| 68 | SIK3 | 0.83395676 |
| 69 | YES1 | 0.83085661 |
| 70 | WNK4 | 0.78951489 |
| 71 | PASK | 0.77817710 |
| 72 | OBSCN | 0.76350772 |
| 73 | CCNB1 | 0.76249559 |
| 74 | CAMK2B | 0.74792667 |
| 75 | MKNK1 | 0.73428314 |
| 76 | EIF2AK2 | 0.72903135 |
| 77 | NTRK3 | 0.72902001 |
| 78 | NEK6 | 0.72029186 |
| 79 | MAPK13 | 0.70901013 |
| 80 | TXK | 0.70386427 |
| 81 | TESK2 | 0.69806356 |
| 82 | GRK1 | 0.66215745 |
| 83 | WNK1 | 0.65928661 |
| 84 | ADRBK1 | 0.63906357 |
| 85 | TTK | 0.63481887 |
| 86 | CSNK2A1 | 0.63402187 |
| 87 | CAMK2D | 0.63099935 |
| 88 | CAMK2A | 0.62989052 |
| 89 | CSNK1A1 | 0.61889675 |
| 90 | CHEK2 | 0.61659694 |
| 91 | MAP3K4 | 0.61431187 |
| 92 | PIK3CA | 0.61361009 |
| 93 | NEK1 | 0.61068310 |
| 94 | CSNK2A2 | 0.59175409 |
| 95 | PRKCE | 0.57732511 |
| 96 | ROCK2 | 0.56503757 |
| 97 | CSNK1E | 0.55021038 |
| 98 | MAP2K6 | 0.54872250 |
| 99 | WNK3 | 0.54526612 |
| 100 | MARK1 | 0.54306436 |
| 101 | CAMK2G | 0.52865333 |
| 102 | CDK8 | 0.52385363 |
| 103 | RPS6KB2 | 0.51969969 |
| 104 | RPS6KA5 | 0.51480309 |
| 105 | UHMK1 | 0.49916846 |
| 106 | PRKCG | 0.47965897 |
| 107 | MKNK2 | 0.47954374 |
| 108 | TESK1 | 0.46915621 |
| 109 | DAPK1 | 0.46615983 |
| 110 | TIE1 | 0.46192815 |
| 111 | CAMKK2 | 0.45654737 |
| 112 | EPHA2 | 0.45318353 |
| 113 | EPHA3 | 0.45171388 |
| 114 | PLK1 | 0.45067843 |
| 115 | CSNK1G1 | 0.44942664 |
| 116 | PRKACA | 0.44286628 |
| 117 | TEC | 0.43800964 |
| 118 | MINK1 | 0.42423826 |
| 119 | CSNK1A1L | 0.42182414 |
| 120 | LATS1 | 0.41372392 |
| 121 | ERBB3 | 0.41206907 |
| 122 | PRKAA1 | 0.41130617 |
| 123 | PIK3CG | 0.40464869 |
| 124 | PRKAA2 | 0.40339980 |
| 125 | PDK2 | 0.38706003 |
| 126 | NEK2 | 0.37896567 |
| 127 | CDK14 | 0.37346465 |
| 128 | FGR | 0.37038706 |
| 129 | PRKCI | 0.36124998 |
| 130 | CSNK1D | 0.35410414 |
| 131 | NUAK1 | 0.35306996 |
| 132 | ALK | 0.35295196 |
| 133 | PRKCA | 0.34728948 |
| 134 | ILK | 0.34554385 |
| 135 | PRKG1 | 0.34453513 |
| 136 | PINK1 | 0.33507444 |
| 137 | CAMK1 | 0.33283008 |
| 138 | BCKDK | 0.32998590 |
| 139 | CSNK1G2 | 0.32668536 |
| 140 | PHKG1 | 0.32598697 |
| 141 | PHKG2 | 0.32598697 |
| 142 | EPHA4 | 0.32256639 |
| 143 | TNK2 | 0.31673369 |
| 144 | CDK18 | 0.31201639 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.89717761 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.97666695 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.60460475 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 4.16636360 |
| 5 | Alzheimers disease_Homo sapiens_hsa05010 | 3.65751619 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.59845833 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.19424287 |
| 8 | Protein export_Homo sapiens_hsa03060 | 3.19230528 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.99952760 |
| 10 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.38315080 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.11355477 |
| 12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.04091909 |
| 13 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.97255470 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.75683309 |
| 15 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.74096896 |
| 16 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.73018147 |
| 17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.71849724 |
| 18 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.67556546 |
| 19 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.67456603 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53130877 |
| 21 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.49921494 |
| 22 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.39572085 |
| 23 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.37435795 |
| 24 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.35113196 |
| 25 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.33456945 |
| 26 | Insulin secretion_Homo sapiens_hsa04911 | 1.29781116 |
| 27 | Homologous recombination_Homo sapiens_hsa03440 | 1.28156696 |
| 28 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.25895781 |
| 29 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.25793350 |
| 30 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.23224794 |
| 31 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.22776678 |
| 32 | Mismatch repair_Homo sapiens_hsa03430 | 1.21816570 |
| 33 | Spliceosome_Homo sapiens_hsa03040 | 1.20701847 |
| 34 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.19784629 |
| 35 | Basal transcription factors_Homo sapiens_hsa03022 | 1.18129528 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.16074814 |
| 37 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.09443687 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.08680052 |
| 39 | Olfactory transduction_Homo sapiens_hsa04740 | 1.07187068 |
| 40 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.05033576 |
| 41 | DNA replication_Homo sapiens_hsa03030 | 1.03133417 |
| 42 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.00992859 |
| 43 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.96294995 |
| 44 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.93476154 |
| 45 | Morphine addiction_Homo sapiens_hsa05032 | 0.92763547 |
| 46 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.92259277 |
| 47 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.91870235 |
| 48 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.91672660 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.91403922 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.91021751 |
| 51 | Circadian rhythm_Homo sapiens_hsa04710 | 0.90653736 |
| 52 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.89494622 |
| 53 | Nicotine addiction_Homo sapiens_hsa05033 | 0.84514477 |
| 54 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.84174282 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 0.84048995 |
| 56 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.80202733 |
| 57 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.79879522 |
| 58 | Circadian entrainment_Homo sapiens_hsa04713 | 0.79245306 |
| 59 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.78563620 |
| 60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.76575485 |
| 61 | RNA degradation_Homo sapiens_hsa03018 | 0.75586524 |
| 62 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.75551270 |
| 63 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.72376880 |
| 64 | Mineral absorption_Homo sapiens_hsa04978 | 0.72083210 |
| 65 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.71692541 |
| 66 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.70660834 |
| 67 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.69437574 |
| 68 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.67138988 |
| 69 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.66186098 |
| 70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65824663 |
| 71 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.63720721 |
| 72 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.63662568 |
| 73 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62600758 |
| 74 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.62225504 |
| 75 | RNA transport_Homo sapiens_hsa03013 | 0.62201357 |
| 76 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.61212928 |
| 77 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.59814952 |
| 78 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.59617475 |
| 79 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.59390653 |
| 80 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.56850378 |
| 81 | Phagosome_Homo sapiens_hsa04145 | 0.55557390 |
| 82 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.54978442 |
| 83 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.53500410 |
| 84 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.52791115 |
| 85 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.52732524 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52549144 |
| 87 | Histidine metabolism_Homo sapiens_hsa00340 | 0.52496144 |
| 88 | Renin secretion_Homo sapiens_hsa04924 | 0.51674184 |
| 89 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.50127159 |
| 90 | Peroxisome_Homo sapiens_hsa04146 | 0.47538060 |
| 91 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.47298316 |
| 92 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.46818795 |
| 93 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.46699350 |
| 94 | Salivary secretion_Homo sapiens_hsa04970 | 0.46681539 |
| 95 | Base excision repair_Homo sapiens_hsa03410 | 0.46251996 |
| 96 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.42986078 |
| 97 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.42479081 |
| 98 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42103418 |
| 99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.40347059 |
| 100 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.40097828 |
| 101 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.39829213 |
| 102 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.39502694 |
| 103 | Taste transduction_Homo sapiens_hsa04742 | 0.39235208 |
| 104 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.39223118 |
| 105 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.39148962 |
| 106 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.38478035 |
| 107 | ABC transporters_Homo sapiens_hsa02010 | 0.37921926 |
| 108 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.37589925 |
| 109 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.37431752 |
| 110 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37103598 |
| 111 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.36771708 |
| 112 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.35846746 |
| 113 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.33877428 |
| 114 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.31005187 |
| 115 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30147837 |
| 116 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.29236389 |
| 117 | GABAergic synapse_Homo sapiens_hsa04727 | 0.26405647 |
| 118 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.25990386 |
| 119 | Other glycan degradation_Homo sapiens_hsa00511 | 0.25599057 |
| 120 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.23749914 |
| 121 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.23609898 |
| 122 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.22847340 |
| 123 | Retinol metabolism_Homo sapiens_hsa00830 | 0.21485742 |
| 124 | Asthma_Homo sapiens_hsa05310 | 0.20092364 |
| 125 | Allograft rejection_Homo sapiens_hsa05330 | 0.19195772 |
| 126 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.18840270 |
| 127 | Alcoholism_Homo sapiens_hsa05034 | 0.18729957 |
| 128 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.18249454 |
| 129 | Cocaine addiction_Homo sapiens_hsa05030 | 0.16448938 |
| 130 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.15910579 |
| 131 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.13916990 |
| 132 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.13752184 |
| 133 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.13112076 |
| 134 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.12208294 |
| 135 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.11760359 |

