CECR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.53906972
2regulation of gamma-delta T cell differentiation (GO:0045586)5.09803419
3positive T cell selection (GO:0043368)5.09300162
4positive thymic T cell selection (GO:0045059)5.04780464
5negative T cell selection (GO:0043383)5.02116372
6regulation of mitochondrial translation (GO:0070129)4.81446185
7peptidyl-arginine omega-N-methylation (GO:0035247)4.79892181
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.70842146
9L-phenylalanine catabolic process (GO:0006559)4.70842146
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.70115479
11L-phenylalanine metabolic process (GO:0006558)4.70115479
12valine metabolic process (GO:0006573)4.69665063
13regulation of gamma-delta T cell activation (GO:0046643)4.62048970
14negative thymic T cell selection (GO:0045060)4.61417006
15DNA strand elongation involved in DNA replication (GO:0006271)4.61148081
16DNA unwinding involved in DNA replication (GO:0006268)4.60245781
17interferon-gamma production (GO:0032609)4.58935978
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58069560
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58069560
20establishment of integrated proviral latency (GO:0075713)4.54015526
21DNA strand elongation (GO:0022616)4.46687350
22lysine metabolic process (GO:0006553)4.43002695
23lysine catabolic process (GO:0006554)4.43002695
24L-serine metabolic process (GO:0006563)4.37231478
25alpha-linolenic acid metabolic process (GO:0036109)4.35966707
26histone arginine methylation (GO:0034969)4.34586063
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.33305778
28aromatic amino acid family catabolic process (GO:0009074)4.30878392
29telomere maintenance via semi-conservative replication (GO:0032201)4.19036452
30indolalkylamine catabolic process (GO:0046218)4.13158984
31tryptophan catabolic process (GO:0006569)4.13158984
32indole-containing compound catabolic process (GO:0042436)4.13158984
33negative regulation of cell killing (GO:0031342)4.12846750
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.12846750
35dicarboxylic acid biosynthetic process (GO:0043650)4.09240116
36peptidyl-arginine N-methylation (GO:0035246)4.05156981
37peptidyl-arginine methylation (GO:0018216)4.05156981
38kynurenine metabolic process (GO:0070189)4.04397042
39formation of translation preinitiation complex (GO:0001731)4.03983546
40thymic T cell selection (GO:0045061)4.02736352
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.97246707
42establishment of viral latency (GO:0019043)3.95780230
43tryptophan metabolic process (GO:0006568)3.95091190
44response to interleukin-15 (GO:0070672)3.94751748
45T cell selection (GO:0045058)3.93524613
46proline biosynthetic process (GO:0006561)3.80874264
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.75236246
482-oxoglutarate metabolic process (GO:0006103)3.67041556
49protein maturation by protein folding (GO:0022417)3.66844977
50negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.65579726
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.64397625
52amino-acid betaine metabolic process (GO:0006577)3.64379291
53ribosomal small subunit assembly (GO:0000028)3.61944832
54antigen processing and presentation of endogenous antigen (GO:0019883)3.61080298
55tricarboxylic acid metabolic process (GO:0072350)3.53685992
56DNA replication initiation (GO:0006270)3.49852442
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.48496063
58glyoxylate metabolic process (GO:0046487)3.48077890
59homocysteine metabolic process (GO:0050667)3.46478748
60cellular response to interleukin-15 (GO:0071350)3.45362547
61pentose-phosphate shunt (GO:0006098)3.44496650
62IMP biosynthetic process (GO:0006188)3.42971084
63T cell migration (GO:0072678)3.40892059
64serine family amino acid catabolic process (GO:0009071)3.40576637
65glycolytic process (GO:0006096)3.40407740
66spliceosomal snRNP assembly (GO:0000387)3.40236395
67high-density lipoprotein particle remodeling (GO:0034375)3.38705335
68urea cycle (GO:0000050)3.38336303
69urea metabolic process (GO:0019627)3.38336303
70purine nucleobase biosynthetic process (GO:0009113)3.36223713
71bile acid biosynthetic process (GO:0006699)3.34779997
72regulation of translational fidelity (GO:0006450)3.34651541
73protein complex localization (GO:0031503)3.34509151
74carnitine metabolic process (GO:0009437)3.33993457
75viral mRNA export from host cell nucleus (GO:0046784)3.29137769
76alpha-amino acid catabolic process (GO:1901606)3.29077859
77ethanol oxidation (GO:0006069)3.27160825
78telomere maintenance via recombination (GO:0000722)3.26932329
79GDP-mannose metabolic process (GO:0019673)3.26234381
80nuclear envelope reassembly (GO:0031468)3.23832470
81mitotic nuclear envelope reassembly (GO:0007084)3.23832470
82pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.23777882
83oxaloacetate metabolic process (GO:0006107)3.22824018
84regulation of isotype switching to IgG isotypes (GO:0048302)3.21221057
85aspartate family amino acid catabolic process (GO:0009068)3.21123549
86nucleobase-containing small molecule interconversion (GO:0015949)3.20904623
87base-excision repair (GO:0006284)3.20890919
88maturation of SSU-rRNA (GO:0030490)3.20539424
89reverse cholesterol transport (GO:0043691)3.19964647
90mitochondrial fusion (GO:0008053)3.19645899
91guanosine-containing compound biosynthetic process (GO:1901070)3.18996623
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18484153
93T cell receptor signaling pathway (GO:0050852)3.17854175
94nucleobase biosynthetic process (GO:0046112)3.17521480
95NADPH regeneration (GO:0006740)3.15128425
96mitotic chromosome condensation (GO:0007076)3.14573012
97succinate metabolic process (GO:0006105)3.13291954
98ribosome biogenesis (GO:0042254)3.13064866
99indolalkylamine metabolic process (GO:0006586)3.11579747
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10873751
101oxidative phosphorylation (GO:0006119)3.10617020
102rRNA transcription (GO:0009303)3.10155152
103pentose metabolic process (GO:0019321)3.09857903
104regulation of cholesterol homeostasis (GO:2000188)3.08555210
105IMP metabolic process (GO:0046040)3.08536637
106mitotic recombination (GO:0006312)3.04834836
107ribosomal small subunit biogenesis (GO:0042274)3.04732754
108cellular modified amino acid catabolic process (GO:0042219)3.04243690
109triglyceride homeostasis (GO:0070328)3.03096289
110acylglycerol homeostasis (GO:0055090)3.03096289
111gluconeogenesis (GO:0006094)3.01564943
112DNA ligation (GO:0006266)3.01299631
113glutamate metabolic process (GO:0006536)3.01251859
114fatty acid homeostasis (GO:0055089)3.00920233
115ribonucleoprotein complex biogenesis (GO:0022613)3.00534494
116bile acid metabolic process (GO:0008206)2.99817591
117plasma lipoprotein particle assembly (GO:0034377)2.99506021
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99127090
119negative regulation of ligase activity (GO:0051352)2.98724342
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98724342
121aromatic amino acid family metabolic process (GO:0009072)2.97776425
122metallo-sulfur cluster assembly (GO:0031163)2.97485855
123iron-sulfur cluster assembly (GO:0016226)2.97485855
124monosaccharide biosynthetic process (GO:0046364)2.97340414
125anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97216989
126cytolysis (GO:0019835)2.97107407
127sulfur amino acid catabolic process (GO:0000098)2.96829972
128pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.96566981
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96315254
130glycine metabolic process (GO:0006544)2.95841545
131cellular amino acid catabolic process (GO:0009063)2.94213563
132negative regulation of mRNA processing (GO:0050686)2.94038850
133tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93471584
134RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93471584
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92656255
136phospholipid efflux (GO:0033700)2.92363253
137ribosomal large subunit biogenesis (GO:0042273)2.92219871
138DNA topological change (GO:0006265)2.91800607
139Golgi transport vesicle coating (GO:0048200)2.91334257
140COPI coating of Golgi vesicle (GO:0048205)2.91334257
141nitrogen cycle metabolic process (GO:0071941)2.90517424
142mitochondrial RNA metabolic process (GO:0000959)2.90467406
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.90461037
144fatty acid beta-oxidation (GO:0006635)2.90415391
145positive regulation of triglyceride biosynthetic process (GO:0010867)2.89985605
146cysteine metabolic process (GO:0006534)2.89979760
147pseudouridine synthesis (GO:0001522)2.89281661
148protein-DNA complex disassembly (GO:0032986)2.89128311
149nucleosome disassembly (GO:0006337)2.89128311
150positive regulation of histone deacetylation (GO:0031065)2.87331211
151viral transcription (GO:0019083)2.87133422
152transcription-coupled nucleotide-excision repair (GO:0006283)2.86106547
153branched-chain amino acid metabolic process (GO:0009081)2.85848912
154mitotic metaphase plate congression (GO:0007080)2.85273925
155hexose biosynthetic process (GO:0019319)2.84572555
156glucose catabolic process (GO:0006007)2.84314935
157folic acid metabolic process (GO:0046655)2.84164738
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82891714
159regulation of triglyceride biosynthetic process (GO:0010866)2.82788649
160negative regulation of cholesterol transport (GO:0032375)2.82115918
161negative regulation of sterol transport (GO:0032372)2.82115918
162serine family amino acid biosynthetic process (GO:0009070)2.81769892
163pyrimidine nucleoside catabolic process (GO:0046135)2.81091037
164UTP biosynthetic process (GO:0006228)2.79552960
165drug transmembrane transport (GO:0006855)2.78895923
166negative regulation of RNA splicing (GO:0033119)2.78757149
167protein-lipid complex remodeling (GO:0034368)2.78633814
168macromolecular complex remodeling (GO:0034367)2.78633814
169plasma lipoprotein particle remodeling (GO:0034369)2.78633814
170coenzyme catabolic process (GO:0009109)2.78389056
171linoleic acid metabolic process (GO:0043651)2.77787090
172negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77305500
173transcription from mitochondrial promoter (GO:0006390)2.76976940
174short-chain fatty acid metabolic process (GO:0046459)2.75579980
175translational elongation (GO:0006414)2.75376090
176tRNA aminoacylation for protein translation (GO:0006418)2.75351995
177very-low-density lipoprotein particle assembly (GO:0034379)2.75347849
178CTP metabolic process (GO:0046036)2.74145168
179CTP biosynthetic process (GO:0006241)2.74145168
180DNA damage response, detection of DNA damage (GO:0042769)2.74139240
181cellular biogenic amine catabolic process (GO:0042402)2.73582606
182amine catabolic process (GO:0009310)2.73582606
183imidazole-containing compound metabolic process (GO:0052803)2.73230023
184protein localization to chromosome, centromeric region (GO:0071459)2.72642229
185regulation of triglyceride catabolic process (GO:0010896)2.72555835
186pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72484849
187one-carbon metabolic process (GO:0006730)2.72411472
188protein retention in ER lumen (GO:0006621)2.72250619
189mitotic sister chromatid segregation (GO:0000070)2.72082491
190nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71793844
191pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71306424
192cellular ketone body metabolic process (GO:0046950)2.71245080
193regulation of fatty acid beta-oxidation (GO:0031998)2.70929559
194protein targeting to mitochondrion (GO:0006626)2.70514087
195translational termination (GO:0006415)2.70399570
196acetyl-CoA metabolic process (GO:0006084)2.70273990
197phospholipid homeostasis (GO:0055091)2.70080465
1984-hydroxyproline metabolic process (GO:0019471)2.69475580
199lipid oxidation (GO:0034440)2.63757318
200fatty acid oxidation (GO:0019395)2.63397081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.12420747
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.29201615
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.25758095
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09994849
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93829079
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.77285336
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.51002898
8MYC_22102868_ChIP-Seq_BL_Human3.44295779
9* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.43075392
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.41778031
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.33424047
12E2F7_22180533_ChIP-Seq_HELA_Human3.09218650
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05410014
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92505586
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82900222
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81612905
17RUNX_20019798_ChIP-Seq_JUKART_Human2.75238015
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57856072
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.57258732
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52203613
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51814091
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.50220683
23GATA1_22025678_ChIP-Seq_K562_Human2.50186000
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50012079
25XRN2_22483619_ChIP-Seq_HELA_Human2.43873854
26* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43493478
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.43136145
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41068827
29* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.40024924
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.37028532
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32850196
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29026848
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.28313371
34* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24447872
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.19696051
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16837293
37MYB_26560356_Chip-Seq_TH2_Human2.10173656
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09060865
39CIITA_25753668_ChIP-Seq_RAJI_Human2.05596886
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03524683
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01375049
42FOXM1_23109430_ChIP-Seq_U2OS_Human2.00607562
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.99729903
44MYB_26560356_Chip-Seq_TH1_Human1.98456280
45DCP1A_22483619_ChIP-Seq_HELA_Human1.98197390
46* GABP_19822575_ChIP-Seq_HepG2_Human1.94856333
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94041012
48UTX_26944678_Chip-Seq_JUKART_Human1.92279751
49MAF_26560356_Chip-Seq_TH1_Human1.91154154
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.84754078
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83488180
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82750242
53TCF7_22412390_ChIP-Seq_EML_Mouse1.81596577
54SCL_19346495_ChIP-Seq_HPC-7_Human1.80732856
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78401021
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71975758
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.71566299
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70606970
59TTF2_22483619_ChIP-Seq_HELA_Human1.70427472
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69198521
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68845651
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.67884814
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66959045
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66481034
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65734713
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58556427
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52408433
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51166938
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48415601
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47710317
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47424059
72KDM5A_27292631_Chip-Seq_BREAST_Human1.47341244
73ZNF263_19887448_ChIP-Seq_K562_Human1.45953645
74GATA3_27048872_Chip-Seq_THYMUS_Human1.45784979
75FOXP3_21729870_ChIP-Seq_TREG_Human1.44264525
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42416537
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41588537
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.40968302
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40420103
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40215447
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.35794307
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32939610
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32619203
84KDM2B_26808549_Chip-Seq_DND41_Human1.32258049
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31918862
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31163131
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.30552539
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30121626
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30002425
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29585002
91MAF_26560356_Chip-Seq_TH2_Human1.29462427
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28594562
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26109609
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25433900
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.25265908
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24761698
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24461409
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24422960
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23864742
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23441037
101VDR_23849224_ChIP-Seq_CD4+_Human1.23416903
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22883885
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22327083
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21825309
105VDR_21846776_ChIP-Seq_THP-1_Human1.21530230
106ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21068546
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20584673
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20029410
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19937034
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19498880
111CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18776793
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17596489
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16513309
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.14161589
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12953324
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12952458
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12741123
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12467380
119FOXA2_19822575_ChIP-Seq_HepG2_Human1.12368277
120ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08854052
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08812914
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08366504
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07926859
124RACK7_27058665_Chip-Seq_MCF-7_Human1.05865518
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05818368
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05687904
127OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05607953
128* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05144440
129* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05097989
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04393521
131TFEB_21752829_ChIP-Seq_HELA_Human1.03869487
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03248840
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02483879
134LXR_22292898_ChIP-Seq_THP-1_Human1.02368897
135RUNX1_22412390_ChIP-Seq_EML_Mouse1.01590004
136KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01354701
137GATA3_26560356_Chip-Seq_TH2_Human1.01210185
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01071986
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00937689
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00801311
141WDR5_24793694_ChIP-Seq_LNCAP_Human1.00716358
142GATA1_19941826_ChIP-Seq_K562_Human1.00161846
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99524540
144* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98415766
145AR_21909140_ChIP-Seq_LNCAP_Human0.97257670
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95336537
147CTCF_26484167_Chip-Seq_Bcells_Mouse0.94394217
148SA1_27219007_Chip-Seq_ERYTHROID_Human0.93578947
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92594436
150NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92333233
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.91629488
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91102753
153* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90787579
154PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89959129
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89558713
156ETS1_21867929_ChIP-Seq_TH2_Mouse0.89356340
157* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89072269
158EGR1_19374776_ChIP-ChIP_THP-1_Human0.88991578
159ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88459906
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86391396
161HNF4A_19822575_ChIP-Seq_HepG2_Human0.86290952
162P68_20966046_ChIP-Seq_HELA_Human0.85920314
163GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85643147
164SPI1_23127762_ChIP-Seq_K562_Human0.84609385
165BCL6_27268052_Chip-Seq_Bcells_Human0.83220567
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82216709
167PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81815012
168VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81794607
169PHF8_20622854_ChIP-Seq_HELA_Human0.80021345
170SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79932717
171TET1_21451524_ChIP-Seq_MESCs_Mouse0.79697967
172GATA2_19941826_ChIP-Seq_K562_Human0.78903179
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78524940
174ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.78350199
175GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78318819
176RARB_27405468_Chip-Seq_BRAIN_Mouse0.77508689
177* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77380388
178RARB_24833708_ChIP-Seq_LIVER_Mouse0.77094787
179BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76962339
180NCOR1_26117541_ChIP-Seq_K562_Human0.76798209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.15411473
2MP0003693_abnormal_embryo_hatching4.85120932
3MP0005365_abnormal_bile_salt4.42915870
4MP0005360_urolithiasis4.26721028
5MP0005085_abnormal_gallbladder_physiolo3.94082543
6MP0003111_abnormal_nucleus_morphology3.75232655
7MP0003763_abnormal_thymus_physiology3.73034331
8MP0003806_abnormal_nucleotide_metabolis3.56135390
9MP0010094_abnormal_chromosome_stability3.42072059
10MP0004957_abnormal_blastocyst_morpholog3.22980189
11MP0003077_abnormal_cell_cycle3.22770859
12MP0008932_abnormal_embryonic_tissue3.22165164
13MP0008058_abnormal_DNA_repair2.99699140
14MP0003252_abnormal_bile_duct2.91639934
15MP0004233_abnormal_muscle_weight2.42144080
16MP0008260_abnormal_autophagy2.37433703
17MP0010030_abnormal_orbit_morphology2.31866524
18MP0008875_abnormal_xenobiotic_pharmacok2.28691667
19MP0004858_abnormal_nervous_system2.28259163
20MP0010329_abnormal_lipoprotein_level2.27460769
21MP0000537_abnormal_urethra_morphology2.21320723
22MP0005671_abnormal_response_to2.18606650
23MP0001730_embryonic_growth_arrest2.17878553
24MP0005670_abnormal_white_adipose2.09572186
25MP0006035_abnormal_mitochondrial_morpho2.09289483
26MP0009278_abnormal_bone_marrow2.03067871
27MP0008007_abnormal_cellular_replicative2.00291886
28MP0000609_abnormal_liver_physiology1.99642356
29MP0003315_abnormal_perineum_morphology1.91823819
30MP0000350_abnormal_cell_proliferation1.90826864
31MP0005058_abnormal_lysosome_morphology1.90728230
32MP0008961_abnormal_basal_metabolism1.90300451
33MP0005332_abnormal_amino_acid1.89049179
34MP0003221_abnormal_cardiomyocyte_apopto1.87352976
35MP0003195_calcinosis1.85892783
36MP0003786_premature_aging1.82098521
37MP0002822_catalepsy1.79828086
38MP0003868_abnormal_feces_composition1.73908316
39MP0000751_myopathy1.72981563
40MP0000685_abnormal_immune_system1.72347103
41MP0002653_abnormal_ependyma_morphology1.70931588
42MP0005083_abnormal_biliary_tract1.70627166
43MP0005646_abnormal_pituitary_gland1.67040310
44MP0001849_ear_inflammation1.66197481
45MP0000703_abnormal_thymus_morphology1.61587847
46MP0000313_abnormal_cell_death1.60815484
47MP0002080_prenatal_lethality1.57121328
48MP0000750_abnormal_muscle_regeneration1.55071254
49MP0000358_abnormal_cell_content/1.54002582
50MP0002398_abnormal_bone_marrow1.53402241
51MP0002138_abnormal_hepatobiliary_system1.52285257
52MP0001672_abnormal_embryogenesis/_devel1.52224965
53MP0005380_embryogenesis_phenotype1.52224965
54MP0001800_abnormal_humoral_immune1.51575953
55MP0000490_abnormal_crypts_of1.51397331
56MP0005499_abnormal_olfactory_system1.48785290
57MP0005394_taste/olfaction_phenotype1.48785290
58MP0002877_abnormal_melanocyte_morpholog1.47469551
59MP0002118_abnormal_lipid_homeostasis1.47391196
60MP0005645_abnormal_hypothalamus_physiol1.46669430
61MP0008789_abnormal_olfactory_epithelium1.44611937
62MP0001666_abnormal_nutrient_absorption1.43066752
63MP0002078_abnormal_glucose_homeostasis1.42739196
64MP0009840_abnormal_foam_cell1.41890846
65MP0002249_abnormal_larynx_morphology1.39476254
66MP0005501_abnormal_skin_physiology1.39231693
67MP0003984_embryonic_growth_retardation1.39033007
68MP0006292_abnormal_olfactory_placode1.37999271
69MP0000049_abnormal_middle_ear1.35128785
70MP0003300_gastrointestinal_ulcer1.34739732
71MP0000747_muscle_weakness1.34209215
72MP0001873_stomach_inflammation1.33863462
73MP0004130_abnormal_muscle_cell1.33260501
74MP0001790_abnormal_immune_system1.32289529
75MP0005387_immune_system_phenotype1.32289529
76MP0001764_abnormal_homeostasis1.32036874
77MP0005584_abnormal_enzyme/coenzyme_acti1.31173617
78MP0006036_abnormal_mitochondrial_physio1.31111942
79MP0004185_abnormal_adipocyte_glucose1.31033570
80MP0002088_abnormal_embryonic_growth/wei1.30735422
81MP0003186_abnormal_redox_activity1.29478285
82MP0001727_abnormal_embryo_implantation1.27556345
83MP0000689_abnormal_spleen_morphology1.27365747
84MP0003866_abnormal_defecation1.26475934
85MP0009643_abnormal_urine_homeostasis1.26451551
86MP0002722_abnormal_immune_system1.25473018
87MP0002085_abnormal_embryonic_tissue1.23308738
88MP0002693_abnormal_pancreas_physiology1.22928467
89MP0004043_abnormal_pH_regulation1.21416619
90MP0002166_altered_tumor_susceptibility1.20516294
91MP0001697_abnormal_embryo_size1.20452830
92MP0009780_abnormal_chondrocyte_physiolo1.19970063
93MP0000716_abnormal_immune_system1.18849713
94MP0004147_increased_porphyrin_level1.17827136
95MP0002396_abnormal_hematopoietic_system1.16931228
96MP0005319_abnormal_enzyme/_coenzyme1.16892888
97MP0005647_abnormal_sex_gland1.16296877
98MP0002420_abnormal_adaptive_immunity1.16102656
99MP0002928_abnormal_bile_duct1.14916693
100MP0003656_abnormal_erythrocyte_physiolo1.13484060
101MP0002723_abnormal_immune_serum1.13052879
102MP0001346_abnormal_lacrimal_gland1.12839262
103MP0001819_abnormal_immune_cell1.12758599
104MP0003718_maternal_effect1.12457385
105MP0001529_abnormal_vocalization1.09023784
106MP0005330_cardiomyopathy1.08994324
107MP0004197_abnormal_fetal_growth/weight/1.08771709
108MP0008877_abnormal_DNA_methylation1.07157413
109MP0005075_abnormal_melanosome_morpholog1.06525315
110MP0002697_abnormal_eye_size1.04574082
111MP0001944_abnormal_pancreas_morphology1.04472863
112MP0004019_abnormal_vitamin_homeostasis1.04119414
113MP0002084_abnormal_developmental_patter1.03162733
114MP0002111_abnormal_tail_morphology1.02490874
115MP0003787_abnormal_imprinting1.02190849
116MP0002429_abnormal_blood_cell1.02125417
117MP0005334_abnormal_fat_pad0.99523037
118MP0002019_abnormal_tumor_incidence0.98237117
119MP0003191_abnormal_cellular_cholesterol0.98199205
120MP0002837_dystrophic_cardiac_calcinosis0.98044646
121MP0004947_skin_inflammation0.97521544
122MP0000759_abnormal_skeletal_muscle0.96688522
123MP0005464_abnormal_platelet_physiology0.94759374
124MP0001835_abnormal_antigen_presentation0.93606867
125MP0000598_abnormal_liver_morphology0.92292145
126MP0003705_abnormal_hypodermis_morpholog0.91820614
127MP0003953_abnormal_hormone_level0.91764640
128MP0001661_extended_life_span0.91671151
129MP0002269_muscular_atrophy0.89869788
130MP0000678_abnormal_parathyroid_gland0.89242313
131MP0005666_abnormal_adipose_tissue0.88900806
132MP0003938_abnormal_ear_development0.88316083
133MP0002796_impaired_skin_barrier0.88102878
134MP0003567_abnormal_fetal_cardiomyocyte0.87208214
135MP0005535_abnormal_body_temperature0.86874881
136MP0009642_abnormal_blood_homeostasis0.86784117
137MP0005384_cellular_phenotype0.86122256
138MP0005451_abnormal_body_composition0.85935572
139MP0005636_abnormal_mineral_homeostasis0.84684380
140MP0009697_abnormal_copulation0.84255390
141MP0005220_abnormal_exocrine_pancreas0.83485489
142MP0009763_increased_sensitivity_to0.82813470
143MP0008469_abnormal_protein_level0.82538954
144MP0002452_abnormal_antigen_presenting0.80900026
145MP0004087_abnormal_muscle_fiber0.80791615
146MP0001853_heart_inflammation0.80014380
147MP0001293_anophthalmia0.79204141
148MP0005171_absent_coat_pigmentation0.78658115
149MP0009333_abnormal_splenocyte_physiolog0.78366905
150MP0002909_abnormal_adrenal_gland0.77527792
151MP0002163_abnormal_gland_morphology0.77130056
152MP0009672_abnormal_birth_weight0.76234138
153MP0002254_reproductive_system_inflammat0.76210225
154MP0000371_diluted_coat_color0.74879710
155MP0002971_abnormal_brown_adipose0.74648944
156MP0003646_muscle_fatigue0.74051097
157MP0010155_abnormal_intestine_physiology0.73558998
158MP0002092_abnormal_eye_morphology0.73532669
159MP0001845_abnormal_inflammatory_respons0.73521370
160MP0000639_abnormal_adrenal_gland0.73028125
161MP0008569_lethality_at_weaning0.71665906
162MP0010630_abnormal_cardiac_muscle0.70718778
163MP0002132_abnormal_respiratory_system0.70709107
164MP0001765_abnormal_ion_homeostasis0.70665040
165MP0008057_abnormal_DNA_replication0.70507226
166MP0002086_abnormal_extraembryonic_tissu0.70329141
167MP0005266_abnormal_metabolism0.70183001
168MP0003879_abnormal_hair_cell0.69610458
169MP0002006_tumorigenesis0.69550409
170MP0002233_abnormal_nose_morphology0.69342185
171MP0004808_abnormal_hematopoietic_stem0.69043113
172MP0005621_abnormal_cell_physiology0.67744476
173MP0000749_muscle_degeneration0.67090041
174MP0000003_abnormal_adipose_tissue0.67017353
175MP0000733_abnormal_muscle_development0.66981813
176MP0005000_abnormal_immune_tolerance0.66958284
177MP0009053_abnormal_anal_canal0.66885425
178MP0001243_abnormal_dermal_layer0.66838920
179MP0000681_abnormal_thyroid_gland0.65759382
180MP0001881_abnormal_mammary_gland0.65070416
181MP0002938_white_spotting0.64198682
182MP0000858_altered_metastatic_potential0.63848365
183MP0002210_abnormal_sex_determination0.63045266
184MP0002234_abnormal_pharynx_morphology0.62833789
185MP0001145_abnormal_male_reproductive0.59369869

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.86675911
2T lymphocytopenia (HP:0005403)4.74047998
3Ragged-red muscle fibers (HP:0003200)4.69491405
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.57017955
5Abnormality of T cell number (HP:0011839)4.41476495
6Hypoglycemic seizures (HP:0002173)4.41235081
7Intrahepatic cholestasis (HP:0001406)4.21555592
8Microvesicular hepatic steatosis (HP:0001414)4.20768357
9Cholecystitis (HP:0001082)4.11181906
10Abnormal gallbladder physiology (HP:0012438)4.11181906
11Hyperinsulinemic hypoglycemia (HP:0000825)4.08604584
12Progressive muscle weakness (HP:0003323)4.04691917
13Ketosis (HP:0001946)3.96860239
14Ketoacidosis (HP:0001993)3.83188067
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62061969
16Symptomatic seizures (HP:0011145)3.52405010
17Renal cortical cysts (HP:0000803)3.44585112
18Hyperammonemia (HP:0001987)3.43994236
19Abnormality of glycolysis (HP:0004366)3.40893352
20Exercise-induced muscle cramps (HP:0003710)3.34016862
21Prolonged partial thromboplastin time (HP:0003645)3.25283411
22Deep venous thrombosis (HP:0002625)3.25030668
23Abnormality of T cells (HP:0002843)3.22652043
24Hypoplasia of the thymus (HP:0000778)3.19950518
25Hyperlipoproteinemia (HP:0010980)3.16376792
26Abnormality of the fingertips (HP:0001211)3.11065363
27Limb hypertonia (HP:0002509)3.10846370
28Hypobetalipoproteinemia (HP:0003563)3.09253301
29Rhabdomyolysis (HP:0003201)3.04431385
30Xanthomatosis (HP:0000991)2.91767385
31Generalized aminoaciduria (HP:0002909)2.90312632
32Myoglobinuria (HP:0002913)2.88979943
33Increased serum pyruvate (HP:0003542)2.87329767
34Myopathic facies (HP:0002058)2.84208162
35Hyperglycinuria (HP:0003108)2.83888696
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.82142845
37Severe combined immunodeficiency (HP:0004430)2.80693810
38Hyperbilirubinemia (HP:0002904)2.79533479
39Exercise-induced myalgia (HP:0003738)2.79060387
40Abnormal mitochondria in muscle tissue (HP:0008316)2.78973628
41Reticulocytopenia (HP:0001896)2.75387595
42Cortical dysplasia (HP:0002539)2.75118759
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.74268838
44Late onset (HP:0003584)2.73988927
45Pancreatic islet-cell hyperplasia (HP:0004510)2.72261134
46Combined immunodeficiency (HP:0005387)2.71770156
47Multiple enchondromatosis (HP:0005701)2.71308406
48Testicular atrophy (HP:0000029)2.70806082
49Panhypogammaglobulinemia (HP:0003139)2.68809053
50Abnormality of fatty-acid metabolism (HP:0004359)2.67031873
51Broad distal phalanx of finger (HP:0009836)2.66680876
52Conjugated hyperbilirubinemia (HP:0002908)2.65935708
53Selective tooth agenesis (HP:0001592)2.65406284
54Abnormality of endocrine pancreas physiology (HP:0012093)2.65344500
55Abnormality of the pancreatic islet cells (HP:0006476)2.65344500
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.64960163
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.62193891
58Abnormal number of erythroid precursors (HP:0012131)2.58726697
59Increased muscle lipid content (HP:0009058)2.57651330
60Abnormality of methionine metabolism (HP:0010901)2.57487158
61High anterior hairline (HP:0009890)2.56059900
62Shoulder girdle muscle weakness (HP:0003547)2.55606256
63Abnormality of cells of the erythroid lineage (HP:0012130)2.55420749
64Trismus (HP:0000211)2.55084316
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54035897
66Hyperglycinemia (HP:0002154)2.53437409
67Hypolipoproteinemia (HP:0010981)2.52849760
68Exercise intolerance (HP:0003546)2.52746439
69Increased intramyocellular lipid droplets (HP:0012240)2.51833658
70Abnormality of serine family amino acid metabolism (HP:0010894)2.49909810
71Abnormality of glycine metabolism (HP:0010895)2.49909810
72Mitral stenosis (HP:0001718)2.47796401
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47713907
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47713907
75Hypoalphalipoproteinemia (HP:0003233)2.47346037
76Chronic diarrhea (HP:0002028)2.43508721
77Type I transferrin isoform profile (HP:0003642)2.43353153
78Spastic diplegia (HP:0001264)2.38727314
79Acute encephalopathy (HP:0006846)2.38458832
80Reduced antithrombin III activity (HP:0001976)2.38028664
81Abnormality of the common coagulation pathway (HP:0010990)2.37934674
82Hepatocellular necrosis (HP:0001404)2.37854058
83Abnormality of pyrimidine metabolism (HP:0004353)2.37257754
84Prominent metopic ridge (HP:0005487)2.35920357
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.35400159
86Joint hemorrhage (HP:0005261)2.34807791
87Abnormality of the intrinsic pathway (HP:0010989)2.34415631
88Hyperglycemia (HP:0003074)2.33832641
89Cholelithiasis (HP:0001081)2.33280681
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32073391
91Abnormality of the anterior horn cell (HP:0006802)2.30916512
92Degeneration of anterior horn cells (HP:0002398)2.30916512
93Joint swelling (HP:0001386)2.30551770
94B lymphocytopenia (HP:0010976)2.28384193
95Abnormality of B cell number (HP:0010975)2.28384193
96Nasal polyposis (HP:0100582)2.26989622
97Hepatocellular carcinoma (HP:0001402)2.25862808
98Abnormal protein glycosylation (HP:0012346)2.25703358
99Abnormal glycosylation (HP:0012345)2.25703358
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25703358
101Abnormal protein N-linked glycosylation (HP:0012347)2.25703358
102Recurrent bronchitis (HP:0002837)2.25376314
103Acute necrotizing encephalopathy (HP:0006965)2.23736674
104Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23315021
105Abnormality of nucleobase metabolism (HP:0010932)2.22620716
106Metabolic acidosis (HP:0001942)2.22424315
107Dicarboxylic aciduria (HP:0003215)2.21268122
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21268122
109Gout (HP:0001997)2.21053700
110Progressive external ophthalmoplegia (HP:0000590)2.19879146
111Truncus arteriosus (HP:0001660)2.19194067
112Lactic acidosis (HP:0003128)2.19014356
113Increased serum lactate (HP:0002151)2.18649758
114Microretrognathia (HP:0000308)2.18364323
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16124875
116Abnormality of purine metabolism (HP:0004352)2.15302196
117Death in childhood (HP:0003819)2.15286216
118Recurrent viral infections (HP:0004429)2.13515523
119Abnormality of reticulocytes (HP:0004312)2.12181564
120Epidermoid cyst (HP:0200040)2.11468634
121Hepatic necrosis (HP:0002605)2.10854350
122Long palpebral fissure (HP:0000637)2.09514763
123Enlarged kidneys (HP:0000105)2.09176171
124Fat malabsorption (HP:0002630)2.08963740
125Proximal placement of thumb (HP:0009623)2.08564448
126Abnormality of the gallbladder (HP:0005264)2.08244647
127Rough bone trabeculation (HP:0100670)2.06824932
128Breech presentation (HP:0001623)2.05909174
129Acute hepatic failure (HP:0006554)2.04688756
130Abnormality of the renal cortex (HP:0011035)2.03656676
131Abnormality of the umbilical cord (HP:0010881)2.02074709
132Death in infancy (HP:0001522)2.00664060
133Neonatal hypoglycemia (HP:0001998)2.00655123
134Calcaneovalgus deformity (HP:0001848)2.00312803
135Hyperacusis (HP:0010780)1.99358843
136Abnormality of serum amino acid levels (HP:0003112)1.97509083
137IgM deficiency (HP:0002850)1.96845285
138Horseshoe kidney (HP:0000085)1.95617993
139Status epilepticus (HP:0002133)1.95076797
140Cerebral edema (HP:0002181)1.94597602
141Abnormality of T cell physiology (HP:0011840)1.94412153
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93717160
143Mitochondrial inheritance (HP:0001427)1.93624046
144Vertebral compression fractures (HP:0002953)1.91938448
145IgG deficiency (HP:0004315)1.91421460
146Muscle stiffness (HP:0003552)1.89077467
147Chronic hepatic failure (HP:0100626)1.87573956
148Pelvic girdle muscle weakness (HP:0003749)1.87235442
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86319679
150Absent epiphyses (HP:0010577)1.86319679
151Abnormality of the metopic suture (HP:0005556)1.85079709
152Increased CSF lactate (HP:0002490)1.84517053
153Upper motor neuron abnormality (HP:0002127)1.84145285
154Deviation of the thumb (HP:0009603)1.83335542
155Postnatal microcephaly (HP:0005484)1.83181711
156Abnormal gallbladder morphology (HP:0012437)1.83098691
157Reticulocytosis (HP:0001923)1.82241865
158Delayed CNS myelination (HP:0002188)1.82143732
159Large for gestational age (HP:0001520)1.81721296
160Cerebral hypomyelination (HP:0006808)1.81100638
161Facial cleft (HP:0002006)1.79759206
162Confusion (HP:0001289)1.78023988
163Complement deficiency (HP:0004431)1.77288933
164Hemiplegia (HP:0002301)1.76713056
165Elevated hepatic transaminases (HP:0002910)1.76186526
166Abnormality of the calcaneus (HP:0008364)1.76160328
167Cutaneous melanoma (HP:0012056)1.75855147
168Neonatal onset (HP:0003623)1.74201857
169Hypergonadotropic hypogonadism (HP:0000815)1.73825529
170Hypertensive crisis (HP:0100735)1.73115016
171Lymphopenia (HP:0001888)1.73026647
172Abnormality of the fetal cardiovascular system (HP:0010948)1.72555265
173Abnormal umbilical cord blood vessels (HP:0011403)1.72555265
174Single umbilical artery (HP:0001195)1.72555265
175Seborrheic dermatitis (HP:0001051)1.72536629
176Depressed nasal tip (HP:0000437)1.72361377
177Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71543269
178Lipid accumulation in hepatocytes (HP:0006561)1.71092199
179Autoimmune hemolytic anemia (HP:0001890)1.69548618
180Pancytopenia (HP:0001876)1.68823341
181Poikilocytosis (HP:0004447)1.68641926
182Abnormality of the nasal mucosa (HP:0000433)1.68446703
183Chronic otitis media (HP:0000389)1.67052861
184Deformed tarsal bones (HP:0008119)1.67015543
185Gastrointestinal inflammation (HP:0004386)1.66940480
186Opisthotonus (HP:0002179)1.66398530
187Neoplasm of the liver (HP:0002896)1.65194003
188Spastic paraparesis (HP:0002313)1.64541807
189Rimmed vacuoles (HP:0003805)1.63768446
190Abnormality of the tricuspid valve (HP:0001702)1.62839706
191Premature skin wrinkling (HP:0100678)1.60768176
192Abnormal neuron morphology (HP:0012757)1.59952757
193Abnormality of the motor neurons (HP:0002450)1.59952757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.39257062
2VRK24.13956844
3BUB13.74454956
4TXK3.54811618
5MAP4K13.30014484
6INSRR3.25084222
7SMG13.15505738
8SRPK13.05545267
9TESK23.01763663
10FGFR42.75797912
11CDK192.75480855
12JAK32.52878269
13MAP3K102.48320832
14SIK12.43210217
15ITK2.33350679
16TRIB32.31668116
17CDK122.30940681
18BCKDK2.29622375
19FLT32.27218429
20EEF2K2.14329238
21PASK2.11809707
22TESK12.11480432
23BRD42.07503830
24NEK12.04844912
25ARAF1.91003304
26PBK1.82547130
27PIM21.74302906
28PKN21.72410043
29ZAP701.65987878
30PRKD31.62072607
31NME11.58731953
32SCYL21.57303804
33TTK1.56734289
34STK161.56291542
35PRKCH1.54959308
36GRK61.52378178
37MAPK111.48577849
38SGK31.41358672
39IKBKE1.40906493
40JAK11.38304729
41TNK21.37368554
42AURKA1.33798756
43PRPF4B1.32645119
44SGK21.30335654
45TYK21.29632707
46FGFR31.29527502
47MAP3K111.28930839
48CDK71.27520297
49TAOK21.27325945
50NLK1.24564670
51CSNK1G31.23484316
52MAP3K131.22399811
53LIMK11.20272870
54VRK11.19738490
55TAF11.19424304
56PAK41.18896532
57MARK31.18849985
58SIK31.17252752
59MAP3K71.16388052
60DAPK21.15434787
61SIK21.12805210
62ERN11.11654350
63ICK1.06211497
64PDK41.04991047
65PDK31.04991047
66BTK1.04364255
67MAPK71.03249960
68MAP3K141.01300000
69TYRO30.99548816
70CSNK1A1L0.99297896
71BRAF0.98135020
72LCK0.94415262
73CHEK20.93513397
74MAP3K80.88722911
75MAPK120.88541147
76AURKB0.86739173
77MAP2K70.86602167
78PLK10.86204978
79DYRK20.86122619
80BRSK10.83032260
81CDK80.82976139
82PTK60.82889421
83TAOK30.82434421
84JAK20.82062037
85DAPK10.80971617
86RAF10.80683032
87HIPK20.79793174
88KDR0.79556909
89CDC70.79466424
90CSNK1G20.79187543
91RIPK10.78546932
92TEC0.78359610
93TSSK60.77936882
94RPS6KB20.77733441
95PIK3CG0.74951974
96SYK0.74908635
97CSK0.74177448
98NTRK20.74146327
99OBSCN0.73926125
100CSNK1G10.73716283
101CCNB10.73071912
102CDK40.72969506
103TBK10.72815748
104PRKCQ0.71881840
105EPHB10.71833674
106TNIK0.70887392
107MAP2K60.70802625
108PINK10.70781680
109HCK0.69972675
110CHEK10.68779129
111STK100.67633719
112RPS6KA50.66265704
113DYRK30.62568346
114CDK11A0.60561885
115ZAK0.60425792
116PRKD20.60129427
117LRRK20.59407987
118CDC42BPA0.59170047
119CAMK40.58898580
120MAPK150.58374095
121SGK2230.57906844
122SGK4940.57906844
123TTN0.57102690
124AKT20.56366927
125PRKAA20.56131007
126EPHA20.54980775
127NTRK30.54498980
128ATR0.53065158
129PAK10.52236763
130KSR20.52165695
131CDK140.51699475
132PDK10.51317550
133BMX0.50776357
134IRAK30.50580199
135STK380.50309865
136ABL20.49688592
137PDK20.49670928
138CDK150.49049177
139CDK180.46458146
140CDK20.45571972
141PRKAA10.45286892
142WNK30.44995043
143STK40.44478590
144MARK20.43920279
145PLK40.43915541
146MAP2K30.43010528
147MAP2K20.40573857
148WEE10.40516726
149LMTK20.40431000
150EPHA40.40395392
151CSNK2A10.39695462
152CLK10.38457006
153MTOR0.37993378
154NEK20.37701616
155MAPKAPK30.35933873
156CSF1R0.35374569
157CAMK1D0.35056549
158MAPK30.34781357
159DAPK30.34695389
160LYN0.34683283
161CSNK2A20.34510855
162CAMKK10.34012740
163TAOK10.33992350
164DYRK1B0.33370222
165RPS6KA40.32650359
166ILK0.32621255
167CHUK0.31976959
168CDK10.31646229
169IRAK20.31127542
170MAP2K40.30888109
171PRKCI0.30375424
172CDK90.30117325
173PIM10.28621803
174FGFR10.28222155
175MAPK80.28064319

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.32409295
2Nitrogen metabolism_Homo sapiens_hsa009103.49308363
3Base excision repair_Homo sapiens_hsa034103.43474146
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.29859145
5Fatty acid degradation_Homo sapiens_hsa000713.07061002
6Mismatch repair_Homo sapiens_hsa034302.97127099
7Proteasome_Homo sapiens_hsa030502.96807199
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.89664111
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.88886156
10Primary immunodeficiency_Homo sapiens_hsa053402.88398263
11Ribosome_Homo sapiens_hsa030102.60174598
12Spliceosome_Homo sapiens_hsa030402.51500166
13Selenocompound metabolism_Homo sapiens_hsa004502.50702646
14Tryptophan metabolism_Homo sapiens_hsa003802.43049666
15Arginine biosynthesis_Homo sapiens_hsa002202.38683386
16Fatty acid metabolism_Homo sapiens_hsa012122.35665800
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32647503
18Propanoate metabolism_Homo sapiens_hsa006402.29092366
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21761291
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13671418
21Pyrimidine metabolism_Homo sapiens_hsa002402.10655387
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10039035
23Lysine degradation_Homo sapiens_hsa003102.05739765
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96642941
25RNA polymerase_Homo sapiens_hsa030201.96144170
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92312514
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92030391
28Nucleotide excision repair_Homo sapiens_hsa034201.78050712
29Butanoate metabolism_Homo sapiens_hsa006501.76519260
30RNA transport_Homo sapiens_hsa030131.75074972
31Peroxisome_Homo sapiens_hsa041461.73828256
32ABC transporters_Homo sapiens_hsa020101.70958695
33Fatty acid biosynthesis_Homo sapiens_hsa000611.65693267
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58008003
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57943414
36PPAR signaling pathway_Homo sapiens_hsa033201.55367149
37T cell receptor signaling pathway_Homo sapiens_hsa046601.53765029
38Homologous recombination_Homo sapiens_hsa034401.50392863
39Cell cycle_Homo sapiens_hsa041101.48433320
40Pyruvate metabolism_Homo sapiens_hsa006201.48358980
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.48153533
42Complement and coagulation cascades_Homo sapiens_hsa046101.47798666
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46126257
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45779016
45beta-Alanine metabolism_Homo sapiens_hsa004101.41999508
46Parkinsons disease_Homo sapiens_hsa050121.40797952
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35214913
48Bile secretion_Homo sapiens_hsa049761.33650881
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31411807
50One carbon pool by folate_Homo sapiens_hsa006701.27392466
51Biosynthesis of amino acids_Homo sapiens_hsa012301.27192285
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26507085
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.25203432
54Oxidative phosphorylation_Homo sapiens_hsa001901.23252037
55Carbon metabolism_Homo sapiens_hsa012001.22939243
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.14999383
57Other glycan degradation_Homo sapiens_hsa005111.13764227
58mRNA surveillance pathway_Homo sapiens_hsa030151.12982407
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12857744
60Fanconi anemia pathway_Homo sapiens_hsa034601.11810187
61Glucagon signaling pathway_Homo sapiens_hsa049221.11491471
62Starch and sucrose metabolism_Homo sapiens_hsa005001.08589013
63Purine metabolism_Homo sapiens_hsa002301.07946714
64Huntingtons disease_Homo sapiens_hsa050161.04338467
65Insulin resistance_Homo sapiens_hsa049311.03865667
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02070237
67Caffeine metabolism_Homo sapiens_hsa002320.97829086
68Glutathione metabolism_Homo sapiens_hsa004800.96185071
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89462992
70Phenylalanine metabolism_Homo sapiens_hsa003600.86715526
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.85670047
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85635798
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85504797
74Insulin secretion_Homo sapiens_hsa049110.84215023
75Glycerolipid metabolism_Homo sapiens_hsa005610.84106472
76Sulfur relay system_Homo sapiens_hsa041220.83407884
77Retinol metabolism_Homo sapiens_hsa008300.82344136
78Antigen processing and presentation_Homo sapiens_hsa046120.82058418
79Vitamin B6 metabolism_Homo sapiens_hsa007500.80599608
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78777874
81Chemical carcinogenesis_Homo sapiens_hsa052040.78259091
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77041980
83Steroid biosynthesis_Homo sapiens_hsa001000.76462644
84Type II diabetes mellitus_Homo sapiens_hsa049300.76194933
85Alzheimers disease_Homo sapiens_hsa050100.74216136
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.73115102
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72810408
88Measles_Homo sapiens_hsa051620.71864686
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.69195865
90N-Glycan biosynthesis_Homo sapiens_hsa005100.68599074
91RNA degradation_Homo sapiens_hsa030180.68051657
92Staphylococcus aureus infection_Homo sapiens_hsa051500.66631156
93Thyroid cancer_Homo sapiens_hsa052160.65703643
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65631953
95Metabolic pathways_Homo sapiens_hsa011000.64850797
96Bladder cancer_Homo sapiens_hsa052190.64393714
97Histidine metabolism_Homo sapiens_hsa003400.62867219
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61484478
99Folate biosynthesis_Homo sapiens_hsa007900.61333022
100Vibrio cholerae infection_Homo sapiens_hsa051100.60740662
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59495512
102Circadian rhythm_Homo sapiens_hsa047100.58948163
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.58851123
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58845040
105Shigellosis_Homo sapiens_hsa051310.57122256
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56298190
107Tyrosine metabolism_Homo sapiens_hsa003500.55809012
108Epstein-Barr virus infection_Homo sapiens_hsa051690.54919911
109Non-homologous end-joining_Homo sapiens_hsa034500.54514666
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53893725
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53462721
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53270457
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52346295
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.52278485
115Arginine and proline metabolism_Homo sapiens_hsa003300.48659358
116Sulfur metabolism_Homo sapiens_hsa009200.48137864
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46862741
118Inositol phosphate metabolism_Homo sapiens_hsa005620.44044339
119Pentose phosphate pathway_Homo sapiens_hsa000300.42212499
120Fatty acid elongation_Homo sapiens_hsa000620.41764560
121Galactose metabolism_Homo sapiens_hsa000520.41433081
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40810502
123Oocyte meiosis_Homo sapiens_hsa041140.40413450
124Fructose and mannose metabolism_Homo sapiens_hsa000510.39240210
125Insulin signaling pathway_Homo sapiens_hsa049100.38346135
126p53 signaling pathway_Homo sapiens_hsa041150.36155439
127Alcoholism_Homo sapiens_hsa050340.35824434
128Viral carcinogenesis_Homo sapiens_hsa052030.35705184
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.34751137
130Hematopoietic cell lineage_Homo sapiens_hsa046400.34446600
131AMPK signaling pathway_Homo sapiens_hsa041520.33753278
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33729553
133Graft-versus-host disease_Homo sapiens_hsa053320.32219492
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30231752
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29239884
136Colorectal cancer_Homo sapiens_hsa052100.29155666
137Vitamin digestion and absorption_Homo sapiens_hsa049770.28869552
138Herpes simplex infection_Homo sapiens_hsa051680.28531214
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28526168
140Systemic lupus erythematosus_Homo sapiens_hsa053220.27947131
141Type I diabetes mellitus_Homo sapiens_hsa049400.26940836
142Acute myeloid leukemia_Homo sapiens_hsa052210.26227172
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26160663
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26036968
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25894916
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25614216
147Cardiac muscle contraction_Homo sapiens_hsa042600.25329086
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24787113
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24072950
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.23505178
151B cell receptor signaling pathway_Homo sapiens_hsa046620.22474433
152Prolactin signaling pathway_Homo sapiens_hsa049170.21901866
153Chronic myeloid leukemia_Homo sapiens_hsa052200.21593391
154HTLV-I infection_Homo sapiens_hsa051660.21278141
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19600173
156Basal transcription factors_Homo sapiens_hsa030220.17572235
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16738284
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.16515978
159Notch signaling pathway_Homo sapiens_hsa043300.14678574

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