ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	7.90999542
2	axonemal dynein complex assembly (GO:0070286)	6.34367318
3	cilium movement (GO:0003341)	5.86962168
4	motile cilium assembly (GO:0044458)	5.67340581
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.65746944
6	epithelial cilium movement (GO:0003351)	5.11010360
7	axoneme assembly (GO:0035082)	4.71964643
8	photoreceptor cell maintenance (GO:0045494)	3.66024996
9	cilium organization (GO:0044782)	3.53016578
10	cilium assembly (GO:0042384)	3.49492439
11	tryptophan catabolic process (GO:0006569)	3.46456180
12	indole-containing compound catabolic process (GO:0042436)	3.46456180
13	indolalkylamine catabolic process (GO:0046218)	3.46456180
14	neural tube formation (GO:0001841)	3.32834362
15	indolalkylamine metabolic process (GO:0006586)	3.31350436
16	regulation of cilium movement (GO:0003352)	3.28841090
17	intraciliary transport (GO:0042073)	3.27788394
18	monoubiquitinated protein deubiquitination (GO:0035520)	3.27238602
19	ventricular system development (GO:0021591)	3.25292857
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.21870999
21	signal peptide processing (GO:0006465)	3.16905916
22	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.13602533
23	regulation of hippo signaling (GO:0035330)	3.12006281
24	one-carbon compound transport (GO:0019755)	3.08835538
25	microtubule polymerization or depolymerization (GO:0031109)	3.05985095
26	cilium morphogenesis (GO:0060271)	3.04143147
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.02671350
28	detection of light stimulus involved in visual perception (GO:0050908)	3.02671350
29	protein localization to cilium (GO:0061512)	3.01971358
30	cellular component assembly involved in morphogenesis (GO:0010927)	3.01434352
31	benzene-containing compound metabolic process (GO:0042537)	2.96745093
32	left/right axis specification (GO:0070986)	2.96643737
33	microtubule bundle formation (GO:0001578)	2.94849293
34	establishment of protein localization to Golgi (GO:0072600)	2.91686982
35	response to nitrosative stress (GO:0051409)	2.90536353
36	retinal cone cell development (GO:0046549)	2.90505574
37	DNA methylation involved in gamete generation (GO:0043046)	2.88054194
38	sphingoid metabolic process (GO:0046519)	2.85536012
39	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.84161952
40	sperm motility (GO:0030317)	2.81153019
41	tryptophan metabolic process (GO:0006568)	2.77653215
42	membrane depolarization during action potential (GO:0086010)	2.76459186
43	cellular response to sterol (GO:0036315)	2.76267060
44	reflex (GO:0060004)	2.76044640
45	kynurenine metabolic process (GO:0070189)	2.75592302
46	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.75549686
47	tachykinin receptor signaling pathway (GO:0007217)	2.69453178
48	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.66821671
49	centriole assembly (GO:0098534)	2.66663612
50	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.65979904
51	protein K48-linked deubiquitination (GO:0071108)	2.65857055
52	cellular ketone body metabolic process (GO:0046950)	2.64877106
53	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.64768139
54	regulation of collateral sprouting (GO:0048670)	2.64438587
55	multicellular organism reproduction (GO:0032504)	2.62221745
56	central nervous system neuron axonogenesis (GO:0021955)	2.57371975
57	indole-containing compound metabolic process (GO:0042430)	2.57346570
58	androgen biosynthetic process (GO:0006702)	2.56365330
59	gamma-aminobutyric acid transport (GO:0015812)	2.56272020
60	protein K11-linked deubiquitination (GO:0035871)	2.54348730
61	glycosphingolipid biosynthetic process (GO:0006688)	2.54066412
62	regulation of skeletal muscle contraction (GO:0014819)	2.53115843
63	serotonin metabolic process (GO:0042428)	2.51249598
64	proline transport (GO:0015824)	2.50672530
65	sialylation (GO:0097503)	2.50226480
66	regulation of pigment cell differentiation (GO:0050932)	2.49778345
67	thyroid hormone metabolic process (GO:0042403)	2.49053866
68	regulation of sarcomere organization (GO:0060297)	2.47124464
69	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.44080113
70	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.43905838
71	positive regulation of developmental pigmentation (GO:0048087)	2.42761693
72	snRNA transcription (GO:0009301)	2.41808662
73	oxidative demethylation (GO:0070989)	2.40917553
74	acrosome reaction (GO:0007340)	2.40568880
75	ketone body metabolic process (GO:1902224)	2.39477688
76	left/right pattern formation (GO:0060972)	2.38285548
77	behavioral response to ethanol (GO:0048149)	2.37881317
78	sensory perception of smell (GO:0007608)	2.37682230
79	protein polyglutamylation (GO:0018095)	2.37148819
80	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.36819084
81	piRNA metabolic process (GO:0034587)	2.35109564
82	centriole replication (GO:0007099)	2.35053037
83	neuronal action potential propagation (GO:0019227)	2.32991935
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.32837569
85	vitamin transmembrane transport (GO:0035461)	2.32338539
86	righting reflex (GO:0060013)	2.31564905
87	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.31102952
88	regulation of translation, ncRNA-mediated (GO:0045974)	2.31102952
89	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.31102952
90	protein K63-linked deubiquitination (GO:0070536)	2.30981672
91	lipid translocation (GO:0034204)	2.30970629
92	phospholipid translocation (GO:0045332)	2.30970629
93	dicarboxylic acid catabolic process (GO:0043649)	2.30478747
94	spinal cord motor neuron differentiation (GO:0021522)	2.30444640
95	interkinetic nuclear migration (GO:0022027)	2.29678121
96	lateral ventricle development (GO:0021670)	2.28658425
97	fucose catabolic process (GO:0019317)	2.27110768
98	L-fucose metabolic process (GO:0042354)	2.27110768
99	L-fucose catabolic process (GO:0042355)	2.27110768
100	presynaptic membrane assembly (GO:0097105)	2.26800125

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.56269959
2	VDR_22108803_ChIP-Seq_LS180_Human	2.99908087
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.79484979
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79087641
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55927016
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48563973
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44603042
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.39386603
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.26347133
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.26113627
11	AR_21572438_ChIP-Seq_LNCaP_Human	2.19690433
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.19087541
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.16150615
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.15566902
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.05907669
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05494890
17	P300_19829295_ChIP-Seq_ESCs_Human	2.04443657
18	SMAD4_21799915_ChIP-Seq_A2780_Human	2.03144502
19	STAT3_23295773_ChIP-Seq_U87_Human	2.01848187
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.01203705
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.91705581
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.87093701
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86460357
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.78887543
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.73753054
26	TCF4_23295773_ChIP-Seq_U87_Human	1.73599804
27	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71459608
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.69658833
29	FUS_26573619_Chip-Seq_HEK293_Human	1.68000342
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.67406856
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61072339
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60976031
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.60976031
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.60573028
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59753622
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59589925
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59153772
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59153772
39	EWS_26573619_Chip-Seq_HEK293_Human	1.57497303
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56933565
41	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54992440
42	AR_25329375_ChIP-Seq_VCAP_Human	1.53763823
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53736421
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52291675
45	RUNX2_22187159_ChIP-Seq_PCA_Human	1.47176518
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.45941425
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.42916615
48	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.42275059
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41116342
50	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.39874198
51	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.39431110
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.39020003
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38394658
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35992653
55	TP53_16413492_ChIP-PET_HCT116_Human	1.35717996
56	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.35439610
57	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.34743002
58	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.33683341
59	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.28906670
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27189469
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23634126
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23571374
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23293892
64	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21124812
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19944669
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.18793205
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18021694
68	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16502686
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15173985
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15173985
71	TBL1_22424771_ChIP-Seq_293T_Human	1.14550589
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14005541
73	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13974186
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13019464
75	CDX2_22108803_ChIP-Seq_LS180_Human	1.12151395
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11977761
77	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.11689459
78	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.11679002
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10150259
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07611309
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06013431
82	RXR_22108803_ChIP-Seq_LS180_Human	1.05055707
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04951483
84	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04384799
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04302571
86	AR_19668381_ChIP-Seq_PC3_Human	1.04126597
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04024513
88	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.03796569
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03016183
90	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.02884679
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.02884679
92	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01751104
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99493552
94	KDM2B_26808549_Chip-Seq_REH_Human	0.98857683
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98481181
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.97617762
97	NFYB_21822215_ChIP-Seq_K562_Human	0.97179187
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97072128
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96844008
100	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.96583983

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.58145642
2	MP0003195_calcinosis	3.10088300
3	MP0003136_yellow_coat_color	2.96795892
4	MP0003890_abnormal_embryonic-extraembry	2.79332843
5	MP0001984_abnormal_olfaction	2.58570633
6	MP0005171_absent_coat_pigmentation	2.57108413
7	MP0002653_abnormal_ependyma_morphology	2.55534601
8	MP0001968_abnormal_touch/_nociception	2.53542493
9	MP0002736_abnormal_nociception_after	2.49451888
10	MP0002102_abnormal_ear_morphology	2.47898233
11	MP0009046_muscle_twitch	2.45463026
12	MP0005551_abnormal_eye_electrophysiolog	2.28529128
13	MP0001501_abnormal_sleep_pattern	2.23448376
14	MP0004043_abnormal_pH_regulation	2.13569014
15	MP0002735_abnormal_chemical_nociception	2.08423390
16	MP0001486_abnormal_startle_reflex	1.98659338
17	MP0009745_abnormal_behavioral_response	1.94354408
18	MP0003646_muscle_fatigue	1.90311262
19	MP0003880_abnormal_central_pattern	1.86620482
20	MP0005253_abnormal_eye_physiology	1.79050275
21	MP0001485_abnormal_pinna_reflex	1.75319782
22	MP0003635_abnormal_synaptic_transmissio	1.73433193
23	MP0005646_abnormal_pituitary_gland	1.71725912
24	MP0004859_abnormal_synaptic_plasticity	1.71491495
25	MP0008057_abnormal_DNA_replication	1.70638662
26	MP0002272_abnormal_nervous_system	1.70473581
27	MP0000372_irregular_coat_pigmentation	1.69468972
28	MP0005174_abnormal_tail_pigmentation	1.61289255
29	MP0002572_abnormal_emotion/affect_behav	1.60373513
30	MP0003045_fibrosis	1.55110506
31	MP0002064_seizures	1.53160371
32	MP0004133_heterotaxia	1.50992101
33	MP0004147_increased_porphyrin_level	1.50120860
34	MP0002837_dystrophic_cardiac_calcinosis	1.48264186
35	MP0000383_abnormal_hair_follicle	1.43855732
36	MP0008872_abnormal_physiological_respon	1.41963624
37	MP0006276_abnormal_autonomic_nervous	1.40543746
38	MP0005410_abnormal_fertilization	1.39634467
39	MP0004215_abnormal_myocardial_fiber	1.36718275
40	MP0002067_abnormal_sensory_capabilities	1.33223340
41	MP0008004_abnormal_stomach_pH	1.32512984
42	MP0003698_abnormal_male_reproductive	1.31053814
43	MP0002168_other_aberrant_phenotype	1.28772648
44	MP0000015_abnormal_ear_pigmentation	1.28582829
45	MP0005377_hearing/vestibular/ear_phenot	1.27678019
46	MP0003878_abnormal_ear_physiology	1.27678019
47	MP0001970_abnormal_pain_threshold	1.26855965
48	MP0002734_abnormal_mechanical_nocicepti	1.25899838
49	MP0005423_abnormal_somatic_nervous	1.24411973
50	MP0002063_abnormal_learning/memory/cond	1.23577384
51	MP0008875_abnormal_xenobiotic_pharmacok	1.23442038
52	MP0001986_abnormal_taste_sensitivity	1.23087621
53	MP0002557_abnormal_social/conspecific_i	1.22709379
54	MP0010386_abnormal_urinary_bladder	1.21787061
55	MP0002229_neurodegeneration	1.20048419
56	MP0005386_behavior/neurological_phenoty	1.17977271
57	MP0004924_abnormal_behavior	1.17977271
58	MP0006072_abnormal_retinal_apoptosis	1.16568554
59	MP0008995_early_reproductive_senescence	1.13128700
60	MP0004085_abnormal_heartbeat	1.12952564
61	MP0006054_spinal_hemorrhage	1.09380367
62	MP0000427_abnormal_hair_cycle	1.07999233
63	MP0008877_abnormal_DNA_methylation	1.06886012
64	MP0003950_abnormal_plasma_membrane	1.02890462
65	MP0005499_abnormal_olfactory_system	1.01320394
66	MP0005394_taste/olfaction_phenotype	1.01320394
67	MP0004145_abnormal_muscle_electrophysio	1.00258591
68	MP0001963_abnormal_hearing_physiology	0.99243971
69	MP0001929_abnormal_gametogenesis	0.98971301
70	MP0002090_abnormal_vision	0.98836491
71	MP0000631_abnormal_neuroendocrine_gland	0.98357458
72	MP0005075_abnormal_melanosome_morpholog	0.97613886
73	MP0003633_abnormal_nervous_system	0.96917002
74	MP0002638_abnormal_pupillary_reflex	0.95430473
75	MP0003119_abnormal_digestive_system	0.95369163
76	MP0005670_abnormal_white_adipose	0.94201798
77	MP0005395_other_phenotype	0.93834058
78	MP0004885_abnormal_endolymph	0.90452492
79	MP0003879_abnormal_hair_cell	0.90287720
80	MP0002938_white_spotting	0.89711395
81	MP0002733_abnormal_thermal_nociception	0.88789856
82	MP0003137_abnormal_impulse_conducting	0.88755549
83	MP0005645_abnormal_hypothalamus_physiol	0.87833704
84	MP0003631_nervous_system_phenotype	0.87643255
85	MP0002882_abnormal_neuron_morphology	0.86078648
86	MP0004381_abnormal_hair_follicle	0.84264304
87	MP0002138_abnormal_hepatobiliary_system	0.84228007
88	MP0002160_abnormal_reproductive_system	0.83871532
89	MP0009780_abnormal_chondrocyte_physiolo	0.83870681
90	MP0002752_abnormal_somatic_nervous	0.82804112
91	MP0002095_abnormal_skin_pigmentation	0.82200123
92	MP0005220_abnormal_exocrine_pancreas	0.79699438
93	MP0010678_abnormal_skin_adnexa	0.79366371
94	MP0005167_abnormal_blood-brain_barrier	0.78738088
95	MP0004270_analgesia	0.77682145
96	MP0003632_abnormal_nervous_system	0.76540108
97	MP0008569_lethality_at_weaning	0.76014895
98	MP0004142_abnormal_muscle_tone	0.74594916
99	MP0001324_abnormal_eye_pigmentation	0.74497892
100	MP0002132_abnormal_respiratory_system	0.73998323

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.94705152
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.94705152
3	Abnormal ciliary motility (HP:0012262)	5.94560274
4	Abnormal respiratory epithelium morphology (HP:0012253)	5.71734414
5	Abnormal respiratory motile cilium morphology (HP:0005938)	5.71734414
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.70130023
7	Abnormal respiratory motile cilium physiology (HP:0012261)	5.61602457
8	Rhinitis (HP:0012384)	4.79678318
9	Pancreatic cysts (HP:0001737)	4.22243095
10	True hermaphroditism (HP:0010459)	3.93422147
11	Pancreatic fibrosis (HP:0100732)	3.88719118
12	Gaze-evoked nystagmus (HP:0000640)	3.59144276
13	Bronchiectasis (HP:0002110)	3.56461020
14	Genetic anticipation (HP:0003743)	3.50131899
15	Cystic liver disease (HP:0006706)	3.42338706
16	Chronic bronchitis (HP:0004469)	3.32565916
17	Progressive cerebellar ataxia (HP:0002073)	3.29456343
18	Nephronophthisis (HP:0000090)	3.28915064
19	Tubulointerstitial nephritis (HP:0001970)	3.27371122
20	Chronic hepatic failure (HP:0100626)	3.26382435
21	Abnormality of midbrain morphology (HP:0002418)	3.20787955
22	Molar tooth sign on MRI (HP:0002419)	3.20787955
23	Hyperventilation (HP:0002883)	3.09330859
24	Abnormality of the renal medulla (HP:0100957)	3.08198937
25	Absent speech (HP:0001344)	2.91674027
26	Febrile seizures (HP:0002373)	2.82414757
27	Medial flaring of the eyebrow (HP:0010747)	2.76327579
28	Attenuation of retinal blood vessels (HP:0007843)	2.71120236
29	Central scotoma (HP:0000603)	2.63842871
30	Abnormality of the renal cortex (HP:0011035)	2.59438907
31	Clumsiness (HP:0002312)	2.59429321
32	Broad-based gait (HP:0002136)	2.57771731
33	Gait imbalance (HP:0002141)	2.49530072
34	Focal motor seizures (HP:0011153)	2.46416136
35	Congenital hepatic fibrosis (HP:0002612)	2.46369669
36	Focal seizures (HP:0007359)	2.44728922
37	Congenital primary aphakia (HP:0007707)	2.43375406
38	Occipital encephalocele (HP:0002085)	2.41052672
39	Nephrogenic diabetes insipidus (HP:0009806)	2.37484232
40	Anencephaly (HP:0002323)	2.36772329
41	Protruding tongue (HP:0010808)	2.29573402
42	Congenital stationary night blindness (HP:0007642)	2.27512421
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26795371
44	Postaxial foot polydactyly (HP:0001830)	2.26178296
45	Male pseudohermaphroditism (HP:0000037)	2.22401122
46	Infertility (HP:0000789)	2.20125995
47	Intestinal atresia (HP:0011100)	2.20087244
48	Bony spicule pigmentary retinopathy (HP:0007737)	2.19999971
49	Genital tract atresia (HP:0001827)	2.15518923
50	Sclerocornea (HP:0000647)	2.09771945
51	Abnormal drinking behavior (HP:0030082)	2.08939906
52	Polydipsia (HP:0001959)	2.08939906
53	Vaginal atresia (HP:0000148)	2.08255256
54	Widely spaced teeth (HP:0000687)	2.08108846
55	Tubulointerstitial abnormality (HP:0001969)	2.05833782
56	Decreased circulating renin level (HP:0003351)	2.03302811
57	Atonic seizures (HP:0010819)	2.02722693
58	Tubular atrophy (HP:0000092)	1.99568624
59	Abolished electroretinogram (ERG) (HP:0000550)	1.98980553
60	Male infertility (HP:0003251)	1.97838270
61	Decreased central vision (HP:0007663)	1.94806771
62	Inability to walk (HP:0002540)	1.92668828
63	Furrowed tongue (HP:0000221)	1.90751564
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89264435
65	Facial diplegia (HP:0001349)	1.89241988
66	Dialeptic seizures (HP:0011146)	1.88768764
67	Recurrent sinusitis (HP:0011108)	1.87777937
68	Cerebellar dysplasia (HP:0007033)	1.87610506
69	Poor coordination (HP:0002370)	1.86346963
70	Progressive inability to walk (HP:0002505)	1.85880290
71	Preaxial hand polydactyly (HP:0001177)	1.84899609
72	Hypoplastic labia majora (HP:0000059)	1.83797755
73	Fair hair (HP:0002286)	1.83518320
74	Abnormality of the ischium (HP:0003174)	1.81628994
75	Abnormality of macular pigmentation (HP:0008002)	1.81504404
76	Small hand (HP:0200055)	1.79589886
77	Congenital sensorineural hearing impairment (HP:0008527)	1.79471775
78	Postaxial hand polydactyly (HP:0001162)	1.77558416
79	Hypoplastic ischia (HP:0003175)	1.76851793
80	Abnormality of the labia majora (HP:0012881)	1.76516607
81	Cupped ear (HP:0000378)	1.75638503
82	Type II lissencephaly (HP:0007260)	1.75459154
83	Hip dysplasia (HP:0001385)	1.75454623
84	Dysmetric saccades (HP:0000641)	1.73352458
85	Scotoma (HP:0000575)	1.71116962
86	Chronic sinusitis (HP:0011109)	1.68845850
87	Highly arched eyebrow (HP:0002553)	1.67682559
88	Labial hypoplasia (HP:0000066)	1.67045392
89	Oculomotor apraxia (HP:0000657)	1.66961553
90	Postural instability (HP:0002172)	1.66841127
91	Retinal dysplasia (HP:0007973)	1.66028949
92	Generalized hypopigmentation of hair (HP:0011358)	1.65875184
93	Retinitis pigmentosa (HP:0000510)	1.65798512
94	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.65599447
95	Hypoplasia of the fovea (HP:0007750)	1.65599447
96	Tented upper lip vermilion (HP:0010804)	1.64770091
97	Blue irides (HP:0000635)	1.64329270
98	Astigmatism (HP:0000483)	1.64299318
99	Short foot (HP:0001773)	1.64255583
100	Oligodactyly (hands) (HP:0001180)	1.62762469

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.19679735
2	ACVR1B	3.45648637
3	BMPR1B	3.36024426
4	LATS1	3.35443714
5	STK38L	2.45392116
6	MAPK15	2.17126757
7	PINK1	2.07276248
8	MAPK13	1.82091559
9	NTRK3	1.78104975
10	CASK	1.71306424
11	ADRBK2	1.69023335
12	INSRR	1.67127551
13	GRK1	1.66610645
14	PRKD3	1.62366318
15	WNK3	1.58420583
16	AKT3	1.57150603
17	TRIM28	1.45110763
18	MKNK2	1.42583332
19	BRD4	1.34843076
20	PTK2B	1.32996285
21	EPHA4	1.30884677
22	STK38	1.30157098
23	ZAK	1.27579402
24	NUAK1	1.22153496
25	MAP3K4	1.17952755
26	DAPK2	1.12529061
27	SGK2	1.08889268
28	STK3	1.07815822
29	TGFBR1	1.07611814
30	FER	1.06194528
31	MARK1	1.03449526
32	PIK3CG	1.02356707
33	TNIK	1.02072167
34	MAP4K2	1.00336262
35	PRKAA2	0.98314178
36	OBSCN	0.98060146
37	MAP3K7	0.97123696
38	TNK2	0.94877919
39	PDK2	0.94021861
40	PLK2	0.93764848
41	MARK3	0.90972611
42	PRKCE	0.90070467
43	ADRBK1	0.89931982
44	BRSK2	0.86487534
45	MST4	0.85416606
46	CAMK1G	0.81864095
47	PKN1	0.80483760
48	FGFR2	0.80228909
49	NLK	0.79638046
50	SGK494	0.79271771
51	SGK223	0.79271771
52	ERBB4	0.79007673
53	PAK3	0.77361742
54	OXSR1	0.76468764
55	PRKCG	0.71728912
56	CSNK1A1L	0.71371192
57	PBK	0.69115764
58	CAMK1	0.65704452
59	CDK3	0.65289794
60	MAP3K2	0.63764672
61	PRKAA1	0.63165993
62	MELK	0.63155506
63	BCR	0.58543868
64	NEK6	0.58514103
65	STK39	0.58319894
66	ERBB3	0.57527540
67	EIF2AK3	0.52932029
68	CAMK2A	0.52725282
69	MYLK	0.51528832
70	CSNK1G1	0.51202401
71	CAMK1D	0.49309661
72	PHKG2	0.47758003
73	PHKG1	0.47758003
74	PNCK	0.46827746
75	MAP2K7	0.46424979
76	TEC	0.45279753
77	PRKCQ	0.44100615
78	PRKCH	0.43937379
79	CAMK4	0.43187901
80	MKNK1	0.42922022
81	ERBB2	0.42381257
82	MAPKAPK3	0.41263572
83	CSNK1G2	0.40936558
84	CCNB1	0.39552781
85	SGK1	0.39417940
86	NEK2	0.39360105
87	SIK2	0.38072160
88	FLT3	0.37202238
89	CSNK1D	0.36622548
90	TAOK3	0.36160507
91	SGK3	0.35879077
92	ROCK1	0.34909462
93	PRKG1	0.34729244
94	TRPM7	0.34667303
95	PKN2	0.34054726
96	MAP2K1	0.32163224
97	RPS6KA3	0.31718086
98	PRKACA	0.31036658
99	CSNK1A1	0.30964294
100	ATM	0.30055461

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.86519445
2	Butanoate metabolism_Homo sapiens_hsa00650	2.67427367
3	Phototransduction_Homo sapiens_hsa04744	2.31572789
4	ABC transporters_Homo sapiens_hsa02010	2.15641613
5	Taste transduction_Homo sapiens_hsa04742	2.14666674
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.12869588
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.08670275
8	Olfactory transduction_Homo sapiens_hsa04740	2.05998303
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.98678256
10	Histidine metabolism_Homo sapiens_hsa00340	1.94886186
11	Chemical carcinogenesis_Homo sapiens_hsa05204	1.82638855
12	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.82478435
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.79543358
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.77281835
15	beta-Alanine metabolism_Homo sapiens_hsa00410	1.76819429
16	Circadian entrainment_Homo sapiens_hsa04713	1.75117540
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66711707
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.66489051
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.63272821
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60171140
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.59100194
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.59059621
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.58220422
24	GABAergic synapse_Homo sapiens_hsa04727	1.55331532
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.53619090
26	Morphine addiction_Homo sapiens_hsa05032	1.52174977
27	Sphingolipid metabolism_Homo sapiens_hsa00600	1.49874226
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49845970
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45565943
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.43971693
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.42014828
32	Salivary secretion_Homo sapiens_hsa04970	1.41940994
33	Propanoate metabolism_Homo sapiens_hsa00640	1.40396422
34	Serotonergic synapse_Homo sapiens_hsa04726	1.31786801
35	Circadian rhythm_Homo sapiens_hsa04710	1.25769696
36	Retinol metabolism_Homo sapiens_hsa00830	1.25758854
37	Insulin secretion_Homo sapiens_hsa04911	1.24613136
38	Lysine degradation_Homo sapiens_hsa00310	1.23515487
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19574699
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18987977
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.12125468
42	Glycerolipid metabolism_Homo sapiens_hsa00561	1.10314471
43	Tyrosine metabolism_Homo sapiens_hsa00350	1.03222640
44	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00480865
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99938382
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97676349
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97651909
48	Gastric acid secretion_Homo sapiens_hsa04971	0.97150556
49	Fatty acid degradation_Homo sapiens_hsa00071	0.96706479
50	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.96588725
51	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.96277284
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.95863426
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90263989
54	Amphetamine addiction_Homo sapiens_hsa05031	0.89909002
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.88256373
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83003062
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82584238
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.82184842
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.81477206
60	Cholinergic synapse_Homo sapiens_hsa04725	0.80887906
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78643673
62	Long-term depression_Homo sapiens_hsa04730	0.78055545
63	Type II diabetes mellitus_Homo sapiens_hsa04930	0.75709638
64	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.75347808
65	Renin secretion_Homo sapiens_hsa04924	0.74266666
66	Cocaine addiction_Homo sapiens_hsa05030	0.73573279
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70818381
68	Peroxisome_Homo sapiens_hsa04146	0.70119402
69	Regulation of autophagy_Homo sapiens_hsa04140	0.70115465
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.70084525
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.66837052
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.64494127
73	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64140849
74	Glutathione metabolism_Homo sapiens_hsa00480	0.60489858
75	Pancreatic secretion_Homo sapiens_hsa04972	0.60411563
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.59061963
77	Caffeine metabolism_Homo sapiens_hsa00232	0.57623609
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53738118
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53573893
80	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53098935
81	Homologous recombination_Homo sapiens_hsa03440	0.52196902
82	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48264753
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.47267708
84	Choline metabolism in cancer_Homo sapiens_hsa05231	0.45731404
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.44213027
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43739447
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43438780
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42078199
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41374550
90	mTOR signaling pathway_Homo sapiens_hsa04150	0.41247998
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40135948
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40110024
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40104342
94	Tight junction_Homo sapiens_hsa04530	0.40076824
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40015816
96	Long-term potentiation_Homo sapiens_hsa04720	0.39553946
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38648278
98	Basal transcription factors_Homo sapiens_hsa03022	0.37530030
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36280672
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.32343931

CECR7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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