CELA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)8.18012261
2intestinal absorption (GO:0050892)8.13800234
3cholesterol catabolic process (GO:0006707)7.38613296
4sterol catabolic process (GO:0016127)7.38613296
5cobalamin metabolic process (GO:0009235)7.24586555
6Golgi transport vesicle coating (GO:0048200)6.91286169
7COPI coating of Golgi vesicle (GO:0048205)6.91286169
8peptidyl-proline hydroxylation (GO:0019511)6.52819091
9negative regulation of digestive system process (GO:0060457)6.37083611
10cysteine metabolic process (GO:0006534)6.24392393
11neutrophil activation involved in immune response (GO:0002283)5.99880590
12glycolipid catabolic process (GO:0019377)5.89755016
13membrane lipid catabolic process (GO:0046466)5.80993992
14regulation of phospholipase A2 activity (GO:0032429)5.75154697
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.37162030
16proline biosynthetic process (GO:0006561)5.33590412
17protein maturation by protein folding (GO:0022417)5.28672159
18response to peptidoglycan (GO:0032494)5.25609123
19ceramide catabolic process (GO:0046514)5.18933226
20positive regulation of nuclease activity (GO:0032075)5.14318135
21positive regulation of gamma-delta T cell activation (GO:0046645)5.13853972
22valine metabolic process (GO:0006573)5.01932923
23protein hydroxylation (GO:0018126)5.00996301
24branched-chain amino acid catabolic process (GO:0009083)4.91176308
25negative regulation of interleukin-12 production (GO:0032695)4.90931728
26endocrine pancreas development (GO:0031018)4.90277012
27endoplasmic reticulum unfolded protein response (GO:0030968)4.80053697
28response to endoplasmic reticulum stress (GO:0034976)4.70233386
29regulation of nuclease activity (GO:0032069)4.67381234
30cellular response to unfolded protein (GO:0034620)4.65966913
31cellular modified amino acid catabolic process (GO:0042219)4.65781156
32intestinal epithelial cell development (GO:0060576)4.47164141
33immunoglobulin mediated immune response (GO:0016064)4.45420337
34ER-nucleus signaling pathway (GO:0006984)4.45292040
35branched-chain amino acid metabolic process (GO:0009081)4.44603918
36cellular response to topologically incorrect protein (GO:0035967)4.43993561
37COPII vesicle coating (GO:0048208)4.42950072
38zinc ion transport (GO:0006829)4.42211763
39signal peptide processing (GO:0006465)4.39515480
40homocysteine metabolic process (GO:0050667)4.37867769
414-hydroxyproline metabolic process (GO:0019471)4.32304368
42serine family amino acid biosynthetic process (GO:0009070)4.19502730
43detection of other organism (GO:0098543)4.18812779
44detection of bacterium (GO:0016045)4.17481552
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.09173547
46maintenance of protein localization in organelle (GO:0072595)4.08707247
47ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.07882732
48aspartate family amino acid catabolic process (GO:0009068)4.06183928
49negative regulation of growth of symbiont in host (GO:0044130)4.04625148
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.04625148
51modulation of growth of symbiont involved in interaction with host (GO:0044144)4.04625148
52regulation of growth of symbiont in host (GO:0044126)4.04625148
53regulation of dendritic cell antigen processing and presentation (GO:0002604)4.04210568
54mitochondrial calcium ion transport (GO:0006851)3.95741483
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.93074122
56L-phenylalanine catabolic process (GO:0006559)3.93074122
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.92398505
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.91129971
59modulation by symbiont of host immune response (GO:0052553)3.91129971
60positive regulation by symbiont of host defense response (GO:0052509)3.91129971
61modulation by symbiont of host defense response (GO:0052031)3.91129971
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91129971
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91129971
64cell wall macromolecule catabolic process (GO:0016998)3.83792494
65response to unfolded protein (GO:0006986)3.81954656
66positive regulation of antigen processing and presentation (GO:0002579)3.81236285
67macrophage activation involved in immune response (GO:0002281)3.77989822
68regulation of mast cell degranulation (GO:0043304)3.77519904
69regulation of T-helper 1 cell differentiation (GO:0045625)3.77234279
70glutamine metabolic process (GO:0006541)3.77188351
71steroid catabolic process (GO:0006706)3.76456765
72microglial cell activation (GO:0001774)3.73542567
73GDP-mannose metabolic process (GO:0019673)3.73463192
74ER overload response (GO:0006983)3.73371705
75leukotriene biosynthetic process (GO:0019370)3.71707182
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.71366102
77L-phenylalanine metabolic process (GO:0006558)3.71366102
78autophagic vacuole fusion (GO:0000046)3.69394429
79response to topologically incorrect protein (GO:0035966)3.68813235
80neutrophil activation (GO:0042119)3.68154131
81positive regulation of mast cell activation (GO:0033005)3.67933741
82positive regulation of mast cell degranulation (GO:0043306)3.67410418
83positive regulation of mast cell activation involved in immune response (GO:0033008)3.67410418
84protein N-linked glycosylation via asparagine (GO:0018279)3.65221818
85myeloid cell activation involved in immune response (GO:0002275)3.63870541
86proline metabolic process (GO:0006560)3.63347668
87peptidyl-asparagine modification (GO:0018196)3.62778518
88L-alpha-amino acid transmembrane transport (GO:1902475)3.62019978
89cellular extravasation (GO:0045123)3.58766225
90coenzyme catabolic process (GO:0009109)3.57511858
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.57120491
92regulation of mast cell activation (GO:0033003)3.56725078
93regulation of mast cell activation involved in immune response (GO:0033006)3.54795557
94positive regulation of B cell differentiation (GO:0045579)3.54731999
95granulocyte activation (GO:0036230)3.52849882
96creatine metabolic process (GO:0006600)3.50665022
97positive regulation of heat generation (GO:0031652)3.47314535
98regulation of gamma-delta T cell activation (GO:0046643)3.45283955
99B cell mediated immunity (GO:0019724)3.42459855
100negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.39339525
101leukocyte degranulation (GO:0043299)3.38351070
102serine family amino acid metabolic process (GO:0009069)3.36012143
103sphingolipid catabolic process (GO:0030149)3.35822140
104regulation of hypersensitivity (GO:0002883)3.35029507
105L-serine metabolic process (GO:0006563)3.34174461
106protein N-linked glycosylation (GO:0006487)3.33636760
107regulation of chemokine biosynthetic process (GO:0045073)3.33569609
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33148321
109phagosome maturation (GO:0090382)3.30154396
110regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26647533
111regulation of fever generation (GO:0031620)3.26425811
112cell redox homeostasis (GO:0045454)3.23278894
113sterol transport (GO:0015918)3.20680515
114cholesterol transport (GO:0030301)3.20680515
115pancreas development (GO:0031016)3.19379825
116antibacterial humoral response (GO:0019731)3.17499333
117neutrophil mediated immunity (GO:0002446)3.16669194
118response to muramyl dipeptide (GO:0032495)3.14294297
119cell wall macromolecule metabolic process (GO:0044036)3.12814218
120positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.11768703
121negative regulation of myeloid cell apoptotic process (GO:0033033)3.11459004
122organelle membrane fusion (GO:0090174)3.10948570
123macrophage activation (GO:0042116)3.10585747
124regulation of antigen processing and presentation (GO:0002577)3.10548825
125sulfur amino acid catabolic process (GO:0000098)3.10322495
126mast cell activation (GO:0045576)3.10296278
127digestive system process (GO:0022600)3.08607605
128negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.08367308
129myeloid leukocyte mediated immunity (GO:0002444)3.03587525
130purine deoxyribonucleotide catabolic process (GO:0009155)3.03561137
131regulation of inflammatory response to antigenic stimulus (GO:0002861)3.02552880
132regulation of germinal center formation (GO:0002634)3.02454516
133regulation of leukocyte degranulation (GO:0043300)3.00248895
134vesicle coating (GO:0006901)2.99319697
135response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98776106
136response to host immune response (GO:0052572)2.98776106
137Golgi organization (GO:0007030)2.98084515
138positive regulation of cellular amide metabolic process (GO:0034250)2.98049248
139positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.96157009
140nucleotide salvage (GO:0043173)2.96049625
141antimicrobial humoral response (GO:0019730)2.94996930
142negative regulation of epidermal cell differentiation (GO:0045605)2.94008160
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93365096
144negative regulation of T cell mediated immunity (GO:0002710)2.93357226
145detection of external biotic stimulus (GO:0098581)2.92973492
146positive regulation of interleukin-1 beta secretion (GO:0050718)2.91586874
147regulation of interleukin-1 beta secretion (GO:0050706)2.87615130
148UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87423070
149lysine metabolic process (GO:0006553)2.87297226
150lysine catabolic process (GO:0006554)2.87297226
151positive regulation of granulocyte differentiation (GO:0030854)2.86340997
152glandular epithelial cell differentiation (GO:0002067)2.85051446
153sulfur amino acid biosynthetic process (GO:0000097)2.83964306
154production of molecular mediator of immune response (GO:0002440)2.83652667
155positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83634803
156positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82573446
157respiratory burst (GO:0045730)2.82084409
158regulation of alpha-beta T cell proliferation (GO:0046640)2.81926688
159lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80752853
160positive regulation of B cell mediated immunity (GO:0002714)2.80243738
161positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80243738
162positive regulation of humoral immune response (GO:0002922)2.79392712
163phagocytosis, engulfment (GO:0006911)2.78506327
164regulation of retinoic acid receptor signaling pathway (GO:0048385)2.76741942
165regulation of B cell receptor signaling pathway (GO:0050855)2.76298260
166purine nucleotide salvage (GO:0032261)2.74677379
167regulation of regulated secretory pathway (GO:1903305)2.74422401
168N-acetylneuraminate metabolic process (GO:0006054)2.73491383
169glycine metabolic process (GO:0006544)2.72757277
170negative regulation of cytokine production involved in immune response (GO:0002719)2.71891472
171nucleotide-sugar biosynthetic process (GO:0009226)2.71677956
172biotin metabolic process (GO:0006768)2.71328045
173negative regulation of phagocytosis (GO:0050765)2.71273487
174alpha-amino acid biosynthetic process (GO:1901607)2.71162598
175positive regulation of interleukin-1 secretion (GO:0050716)2.70677068
176negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70631202
177negative regulation of cell killing (GO:0031342)2.70631202
178germinal center formation (GO:0002467)2.70449230
179peptide catabolic process (GO:0043171)2.70283365
180regulation of B cell differentiation (GO:0045577)2.69754149
181cellular protein catabolic process (GO:0044257)2.69661281
182positive regulation of type 2 immune response (GO:0002830)2.69245375
183tetrapyrrole metabolic process (GO:0033013)2.69171354
184regulation of interleukin-12 production (GO:0032655)2.67860222
185polarized epithelial cell differentiation (GO:0030859)2.67365568
186regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.67123746
187positive regulation of regulated secretory pathway (GO:1903307)2.65829419
188regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.65676333
189positive regulation of interleukin-17 production (GO:0032740)2.65347067
190regulation of interleukin-8 biosynthetic process (GO:0045414)2.64213812
191negative regulation of lymphocyte mediated immunity (GO:0002707)2.64163076
192interferon-gamma-mediated signaling pathway (GO:0060333)2.63645743
193icosanoid secretion (GO:0032309)2.63203803
194detection of molecule of bacterial origin (GO:0032490)2.62437533
195intestinal cholesterol absorption (GO:0030299)17.5575278
196digestion (GO:0007586)13.0785019
197protein retention in ER lumen (GO:0006621)11.9015373
198maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.3085670
199* exocrine pancreas development (GO:0031017)10.5519123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.76972185
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.36661631
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.01525992
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.06421741
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.89138802
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.43648160
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.39915995
8GATA1_22025678_ChIP-Seq_K562_Human3.37598695
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34354018
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25753271
11PPARA_22158963_ChIP-Seq_LIVER_Mouse3.21511568
12SCL_19346495_ChIP-Seq_HPC-7_Human3.18764916
13* IRF8_27001747_Chip-Seq_BMDM_Mouse3.06961270
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.06218366
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01324318
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99945388
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96577852
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90999678
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.90784289
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.89328872
21VDR_21846776_ChIP-Seq_THP-1_Human2.83050336
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78811268
23* LXR_22158963_ChIP-Seq_LIVER_Mouse2.77130848
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76279432
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.59842636
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.56850216
27VDR_24763502_ChIP-Seq_THP-1_Human2.56187090
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52859950
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.48952633
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47327221
31GATA4_25053715_ChIP-Seq_YYC3_Human2.47171912
32SPI1_23547873_ChIP-Seq_NB4_Human2.46537914
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23364253
34SPI1_23127762_ChIP-Seq_K562_Human2.20519721
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20369832
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15023089
37MYB_26560356_Chip-Seq_TH2_Human2.14131736
38* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.11804297
39GATA6_25053715_ChIP-Seq_YYC3_Human2.10231488
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10117089
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.05505822
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01436123
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00920146
44RUNX_20019798_ChIP-Seq_JUKART_Human2.00171364
45* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97872669
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.96066097
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.94027195
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90201327
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.88240861
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.86249971
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84931336
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81654931
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.76469999
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74660262
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.73597454
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72759879
57VDR_24787735_ChIP-Seq_THP-1_Human1.70596938
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67762378
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.67093880
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60534251
61* UTX_26944678_Chip-Seq_JUKART_Human1.60450155
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56808238
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55962348
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54972244
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54730743
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51390425
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.50763093
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48339152
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47114206
70BCL6_27268052_Chip-Seq_Bcells_Human1.46475338
71GATA3_27048872_Chip-Seq_THYMUS_Human1.45896523
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45601675
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45304231
74* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45256600
75CLOCK_20551151_ChIP-Seq_293T_Human1.40946299
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40706476
77STAT1_20625510_ChIP-Seq_HELA_Human1.40562224
78MAF_26560356_Chip-Seq_TH1_Human1.40200427
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40060905
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39816878
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.38310690
82MYB_26560356_Chip-Seq_TH1_Human1.37882799
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37117249
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35925819
85CHD1_26751641_Chip-Seq_LNCaP_Human1.35590333
86* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35567541
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34994451
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34805613
89* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33674893
90* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33083534
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32865559
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32865559
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32865559
94LXR_22292898_ChIP-Seq_THP-1_Human1.29999815
95GATA3_26560356_Chip-Seq_TH2_Human1.28866526
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28681113
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.28059209
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27600903
99EGR1_19032775_ChIP-ChIP_M12_Human1.25688972
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25502331
101SOX2_20726797_ChIP-Seq_SW620_Human1.24677569
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23458749
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22870448
104* CREB1_26743006_Chip-Seq_LNCaP_Human1.22676420
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19906192
106* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18851393
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.17201016
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16818327
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.16806542
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15887356
111FOXA1_25552417_ChIP-Seq_VCAP_Human1.15264376
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.15125891
113ATF3_27146783_Chip-Seq_COLON_Human1.14548281
114PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13694975
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10991521
116FOXH1_21741376_ChIP-Seq_ESCs_Human1.10799913
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09927465
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09680377
119SPI1_20517297_ChIP-Seq_HL60_Human1.08367738
120ESET_19884257_ChIP-Seq_ESCs_Mouse1.08337669
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07719200
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07488723
123* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07444459
124TP63_22573176_ChIP-Seq_HFKS_Human1.06917951
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05989404
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05525137
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05466129
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04316965
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02702505
130* P68_20966046_ChIP-Seq_HELA_Human1.02151406
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.00438054
132MAF_26560356_Chip-Seq_TH2_Human1.00390121
133CTCF_26484167_Chip-Seq_Bcells_Mouse1.00236715
134RACK7_27058665_Chip-Seq_MCF-7_Human1.00090845
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98613165
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97857552
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96796004
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96307334
139P300_27268052_Chip-Seq_Bcells_Human0.96137746
140* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95956319
141IRF1_19129219_ChIP-ChIP_H3396_Human0.95178819
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94942988
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94664638
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.94480967
145* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94311531
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94065460
147ETS1_21867929_ChIP-Seq_TH2_Mouse0.90465211
148BCOR_27268052_Chip-Seq_Bcells_Human0.89907175
149ZNF274_21170338_ChIP-Seq_K562_Hela0.89900997
150* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89686988
151PU_27001747_Chip-Seq_BMDM_Mouse0.88962962
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.88768229
153* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88716807
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87768214
155KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87691464
156GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87442164
157TFEB_21752829_ChIP-Seq_HELA_Human0.86935348
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.86597541
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86496090
160HTT_18923047_ChIP-ChIP_STHdh_Human0.86206018
161SMRT_27268052_Chip-Seq_Bcells_Human0.85939506
162P53_21459846_ChIP-Seq_SAOS-2_Human0.85469558
163* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85142711
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84753748
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84355590
166GATA3_21867929_ChIP-Seq_CD8_Mouse0.84111834
167CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83106681
168RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82837364
169TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82832468
170TBX20_22080862_ChIP-Seq_HEART_Mouse0.82812088
171TBX20_22328084_ChIP-Seq_HEART_Mouse0.82812088
172GATA1_19941826_ChIP-Seq_K562_Human0.82385611
173DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82371419
174RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81986655
175NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81266738
176RAC3_21632823_ChIP-Seq_H3396_Human0.80627711
177PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79999826
178* OCT4_20526341_ChIP-Seq_ESCs_Human0.77179113
179* ERG_20517297_ChIP-Seq_VCAP_Human0.76466390
180KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76057241
181SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75733026
182JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.75199020
183* TAF2_19829295_ChIP-Seq_ESCs_Human0.75005879
184HNF4A_19822575_ChIP-Seq_HepG2_Human0.74332521
185* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73930925
186* ERA_21632823_ChIP-Seq_H3396_Human0.70994910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.51641417
2MP0001666_abnormal_nutrient_absorption8.49975943
3MP0005220_abnormal_exocrine_pancreas6.45149936
4MP0005365_abnormal_bile_salt6.32719868
5MP0003868_abnormal_feces_composition4.86913018
6MP0005084_abnormal_gallbladder_morpholo4.81548037
7MP0001835_abnormal_antigen_presentation3.76178040
8MP0002254_reproductive_system_inflammat3.45891566
9MP0005085_abnormal_gallbladder_physiolo3.37019760
10MP0002138_abnormal_hepatobiliary_system3.32664368
11MP0003303_peritoneal_inflammation3.32419067
12MP0002148_abnormal_hypersensitivity_rea3.18002255
13MP0002693_abnormal_pancreas_physiology3.07292414
14MP0002139_abnormal_hepatobiliary_system3.04948659
15MP0006082_CNS_inflammation3.01206665
16MP0005464_abnormal_platelet_physiology2.94569852
17MP0003724_increased_susceptibility_to2.85527292
18MP0003436_decreased_susceptibility_to2.83456647
19MP0005671_abnormal_response_to2.79779134
20MP0002419_abnormal_innate_immunity2.76723188
21MP0008260_abnormal_autophagy2.68632968
22MP0000685_abnormal_immune_system2.61875186
23MP0009785_altered_susceptibility_to2.54024039
24MP0005000_abnormal_immune_tolerance2.51211490
25MP0003959_abnormal_lean_body2.50128938
26MP0005025_abnormal_response_to2.44928601
27MP0001800_abnormal_humoral_immune2.37521365
28MP0001664_abnormal_digestion2.31726713
29MP0009278_abnormal_bone_marrow2.31659994
30MP0001944_abnormal_pancreas_morphology2.30070749
31MP0002452_abnormal_antigen_presenting2.27899983
32MP0002723_abnormal_immune_serum2.20480814
33MP0003252_abnormal_bile_duct2.17212249
34MP0002420_abnormal_adaptive_immunity2.16339243
35MP0005387_immune_system_phenotype2.14204247
36MP0001790_abnormal_immune_system2.14204247
37MP0001819_abnormal_immune_cell2.12677650
38MP0004264_abnormal_extraembryonic_tissu1.94143151
39MP0002928_abnormal_bile_duct1.89529949
40MP0003763_abnormal_thymus_physiology1.86169939
41MP0003705_abnormal_hypodermis_morpholog1.81579379
42MP0001545_abnormal_hematopoietic_system1.78055694
43MP0005397_hematopoietic_system_phenotyp1.78055694
44MP0009764_decreased_sensitivity_to1.76632823
45MP0010234_abnormal_vibrissa_follicle1.75218745
46MP0009840_abnormal_foam_cell1.72172304
47MP0009333_abnormal_splenocyte_physiolog1.69742213
48MP0010155_abnormal_intestine_physiology1.68587987
49MP0001986_abnormal_taste_sensitivity1.60807849
50MP0002398_abnormal_bone_marrow1.60565919
51MP0000716_abnormal_immune_system1.59742456
52MP0005448_abnormal_energy_balance1.54882852
53MP0003191_abnormal_cellular_cholesterol1.47884174
54MP0002405_respiratory_system_inflammati1.47185042
55MP0001533_abnormal_skeleton_physiology1.47068048
56MP0000343_altered_response_to1.44106445
57MP0000689_abnormal_spleen_morphology1.42165460
58MP0002998_abnormal_bone_remodeling1.41819246
59MP0002118_abnormal_lipid_homeostasis1.38961042
60MP0003638_abnormal_response/metabolism_1.36517433
61MP0008469_abnormal_protein_level1.33854190
62MP0002429_abnormal_blood_cell1.32855770
63MP0003300_gastrointestinal_ulcer1.31834880
64MP0003283_abnormal_digestive_organ1.29561736
65MP0005332_abnormal_amino_acid1.29463762
66MP0005310_abnormal_salivary_gland1.29388834
67MP0002722_abnormal_immune_system1.29115962
68MP0002078_abnormal_glucose_homeostasis1.28660357
69MP0004947_skin_inflammation1.27788533
70MP0003787_abnormal_imprinting1.23470287
71MP0004233_abnormal_muscle_weight1.23450158
72MP0002396_abnormal_hematopoietic_system1.20781352
73MP0008004_abnormal_stomach_pH1.20481554
74MP0000604_amyloidosis1.19506267
75MP0006054_spinal_hemorrhage1.16338988
76MP0005165_increased_susceptibility_to1.15988339
77MP0001853_heart_inflammation1.11607813
78MP0003718_maternal_effect1.11402967
79MP0000858_altered_metastatic_potential1.11130127
80MP0000465_gastrointestinal_hemorrhage1.10818937
81MP0003075_altered_response_to1.10336111
82MP0006035_abnormal_mitochondrial_morpho1.10334376
83MP0008872_abnormal_physiological_respon1.08934167
84MP0009643_abnormal_urine_homeostasis1.06783391
85MP0001851_eye_inflammation1.06605282
86MP0000003_abnormal_adipose_tissue1.06604935
87MP0003045_fibrosis1.05512127
88MP0005451_abnormal_body_composition1.00698797
89MP0009780_abnormal_chondrocyte_physiolo1.00258717
90MP0002277_abnormal_respiratory_mucosa1.00064940
91MP0000470_abnormal_stomach_morphology0.99144233
92MP0003828_pulmonary_edema0.97279827
93MP0005410_abnormal_fertilization0.96991051
94MP0003806_abnormal_nucleotide_metabolis0.95054499
95MP0008057_abnormal_DNA_replication0.94852732
96MP0005647_abnormal_sex_gland0.93222936
97MP0004043_abnormal_pH_regulation0.92067481
98MP0005408_hypopigmentation0.91893671
99MP0005167_abnormal_blood-brain_barrier0.91809782
100MP0000703_abnormal_thymus_morphology0.87997356
101MP0005360_urolithiasis0.87698740
102MP0003953_abnormal_hormone_level0.86785849
103MP0002132_abnormal_respiratory_system0.85513470
104MP0005535_abnormal_body_temperature0.84846062
105MP0004510_myositis0.83983589
106MP0008961_abnormal_basal_metabolism0.83777039
107MP0003866_abnormal_defecation0.81294941
108MP0005174_abnormal_tail_pigmentation0.81077737
109MP0001873_stomach_inflammation0.80606250
110MP0003195_calcinosis0.80154606
111MP0005075_abnormal_melanosome_morpholog0.79404396
112MP0002332_abnormal_exercise_endurance0.78129107
113MP0002877_abnormal_melanocyte_morpholog0.77771006
114MP0009763_increased_sensitivity_to0.77076250
115MP0000613_abnormal_salivary_gland0.75542896
116MP0005058_abnormal_lysosome_morphology0.75348094
117MP0010329_abnormal_lipoprotein_level0.73880963
118MP0005166_decreased_susceptibility_to0.73855139
119MP0004808_abnormal_hematopoietic_stem0.73441605
120MP0001905_abnormal_dopamine_level0.69933167
121MP0000490_abnormal_crypts_of0.69367178
122MP0004381_abnormal_hair_follicle0.66899190
123MP0005377_hearing/vestibular/ear_phenot0.66809343
124MP0003878_abnormal_ear_physiology0.66809343
125MP0000609_abnormal_liver_physiology0.65857341
126MP0003690_abnormal_glial_cell0.64696625
127MP0009384_cardiac_valve_regurgitation0.64660331
128MP0004883_abnormal_blood_vessel0.64429970
129MP0003448_altered_tumor_morphology0.64118955
130MP0000598_abnormal_liver_morphology0.63969350
131MP0005164_abnormal_response_to0.62559992
132MP0000372_irregular_coat_pigmentation0.62116639
133MP0001663_abnormal_digestive_system0.59983958
134MP0005452_abnormal_adipose_tissue0.59878728
135MP0003186_abnormal_redox_activity0.58477167
136MP0005390_skeleton_phenotype0.57813586
137MP0006036_abnormal_mitochondrial_physio0.54970772
138MP0002909_abnormal_adrenal_gland0.54934733
139MP0002876_abnormal_thyroid_physiology0.54758710
140MP0005381_digestive/alimentary_phenotyp0.54685041
141MP0008438_abnormal_cutaneous_collagen0.54509283
142MP0001764_abnormal_homeostasis0.54165450
143MP0000013_abnormal_adipose_tissue0.54041269
144MP0009765_abnormal_xenobiotic_induced0.52568498
145MP0002896_abnormal_bone_mineralization0.50830645
146MP0005375_adipose_tissue_phenotype0.50440811
147MP0001731_abnormal_postnatal_growth0.50417180
148MP0003183_abnormal_peptide_metabolism0.49588137
149MP0005319_abnormal_enzyme/_coenzyme0.48035957
150MP0005187_abnormal_penis_morphology0.46531893
151MP0005636_abnormal_mineral_homeostasis0.45784098
152MP0003943_abnormal_hepatobiliary_system0.45254442
153MP0001845_abnormal_inflammatory_respons0.45130197
154MP0001765_abnormal_ion_homeostasis0.44179714
155MP0008875_abnormal_xenobiotic_pharmacok0.41728852
156MP0009642_abnormal_blood_homeostasis0.41394746
157MP0002098_abnormal_vibrissa_morphology0.41028456
158MP0003656_abnormal_erythrocyte_physiolo0.41023577
159MP0005334_abnormal_fat_pad0.40452742
160MP0003172_abnormal_lysosome_physiology0.40192632
161MP0010386_abnormal_urinary_bladder0.39363668
162MP0003795_abnormal_bone_structure0.36403554
163MP0008789_abnormal_olfactory_epithelium0.36313077
164MP0001756_abnormal_urination0.35597186
165MP0004185_abnormal_adipocyte_glucose0.34983490
166MP0002089_abnormal_postnatal_growth/wei0.34409472
167MP0003329_amyloid_beta_deposits0.34347336
168MP0009703_decreased_birth_body0.32323340
169MP0002234_abnormal_pharynx_morphology0.32037632
170MP0002796_impaired_skin_barrier0.31674293
171MP0000371_diluted_coat_color0.29848492
172MP0000462_abnormal_digestive_system0.29578196
173MP0000367_abnormal_coat/_hair0.29106255
174MP0002069_abnormal_eating/drinking_beha0.29007530
175MP0001348_abnormal_lacrimal_gland0.28975003
176MP0002060_abnormal_skin_morphology0.28182045
177MP0000377_abnormal_hair_follicle0.27911712
178MP0004272_abnormal_basement_membrane0.27288221
179MP0009672_abnormal_birth_weight0.26933594
180MP0002168_other_aberrant_phenotype0.25517529

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.52270796
2Gout (HP:0001997)6.60571480
3Fat malabsorption (HP:0002630)6.58254227
4Decreased subcutaneous fat (HP:0001002)5.22455099
5Exocrine pancreatic insufficiency (HP:0001738)4.98500415
6Short chin (HP:0000331)4.98445598
7Abnormal pancreas size (HP:0012094)4.82948033
8Abnormality of the intrinsic pathway (HP:0010989)4.74649417
9Abnormality of subcutaneous fat tissue (HP:0001001)4.68103058
10Type I diabetes mellitus (HP:0100651)4.64122459
11Abnormality of liposaccharide metabolism (HP:0010968)4.49868126
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.49868126
13Abnormality of glycolipid metabolism (HP:0010969)4.49868126
14Abnormality of macrophages (HP:0004311)4.44613320
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32825344
16Myositis (HP:0100614)4.30731016
17Ketoacidosis (HP:0001993)4.30395923
18Hypoglycemic coma (HP:0001325)4.23967424
19Abnormality of endocrine pancreas physiology (HP:0012093)4.14632275
20Abnormality of the pancreatic islet cells (HP:0006476)4.14632275
21Stomatitis (HP:0010280)4.13224355
22Maternal diabetes (HP:0009800)4.04471916
23Hyperinsulinemic hypoglycemia (HP:0000825)4.02908026
24Increased circulating renin level (HP:0000848)3.99559210
25Hypoglycemic seizures (HP:0002173)3.99267694
26Ketosis (HP:0001946)3.98693000
27Retrobulbar optic neuritis (HP:0100654)3.93242045
28Optic neuritis (HP:0100653)3.93242045
29Increased cerebral lipofuscin (HP:0011813)3.84982915
30Bilateral sensorineural hearing impairment (HP:0008619)3.77525748
31Orchitis (HP:0100796)3.75494269
32Late onset (HP:0003584)3.70836384
33Recurrent abscess formation (HP:0002722)3.67426857
34Recurrent bacterial skin infections (HP:0005406)3.66318320
35Elevated erythrocyte sedimentation rate (HP:0003565)3.64509149
36Hypoplasia of the pons (HP:0012110)3.56103240
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.55974885
38Keratoconjunctivitis (HP:0001096)3.54793297
39Tubulointerstitial fibrosis (HP:0005576)3.48178386
40Mediastinal lymphadenopathy (HP:0100721)3.47806602
41Pancreatitis (HP:0001733)3.45916873
42Thrombocytosis (HP:0001894)3.42171829
43Obstructive lung disease (HP:0006536)3.39615964
44Chronic obstructive pulmonary disease (HP:0006510)3.39615964
45Abnormality of the pons (HP:0007361)3.34976422
46Prolonged bleeding time (HP:0003010)3.33139340
47Tetany (HP:0001281)3.31990602
48Eczematoid dermatitis (HP:0000976)3.29292170
49Joint stiffness (HP:0001387)3.27202298
50Mutism (HP:0002300)3.26762227
51Abnormality of the common coagulation pathway (HP:0010990)3.17466797
52Autoimmune thrombocytopenia (HP:0001973)3.11861815
53Premature skin wrinkling (HP:0100678)3.10753897
54Petechiae (HP:0000967)3.06830834
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.06387817
56Increased purine levels (HP:0004368)3.02998704
57Hyperuricemia (HP:0002149)3.02998704
58Recurrent fungal infections (HP:0002841)3.00502086
59Symptomatic seizures (HP:0011145)2.99681101
60Loss of speech (HP:0002371)2.98901880
61Meningitis (HP:0001287)2.98551211
62Epistaxis (HP:0000421)2.97705870
63Eosinophilia (HP:0001880)2.95557254
64Paralysis (HP:0003470)2.88411271
65Granulocytopenia (HP:0001913)2.86391902
66Hypomagnesemia (HP:0002917)2.84726919
67Purpura (HP:0000979)2.81729993
68Hyperglycemia (HP:0003074)2.81728263
69Hypokalemic alkalosis (HP:0001949)2.81643442
70Pulmonary infiltrates (HP:0002113)2.80880522
71Recurrent gram-negative bacterial infections (HP:0005420)2.76546287
72Tubulointerstitial nephritis (HP:0001970)2.75375188
73Keratoconjunctivitis sicca (HP:0001097)2.75252213
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.73292602
75Hypoproteinemia (HP:0003075)2.72771579
76Vasculitis (HP:0002633)2.70659718
77Cortical dysplasia (HP:0002539)2.70228549
78Amyloidosis (HP:0011034)2.69659929
79Encephalitis (HP:0002383)2.68779793
80Abnormality of magnesium homeostasis (HP:0004921)2.68533261
81Pustule (HP:0200039)2.67576691
82Leukocytosis (HP:0001974)2.66739224
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.66544168
84Hyperglycinemia (HP:0002154)2.64720219
85Recurrent skin infections (HP:0001581)2.62286153
86Hemoptysis (HP:0002105)2.60630141
87Esophageal varix (HP:0002040)2.59657514
88Spontaneous hematomas (HP:0007420)2.58835830
89Abnormal drinking behavior (HP:0030082)2.57678898
90Polydipsia (HP:0001959)2.57678898
91Large for gestational age (HP:0001520)2.57253361
92Dysostosis multiplex (HP:0000943)2.56192324
93Unilateral renal agenesis (HP:0000122)2.55856384
94Recurrent cutaneous fungal infections (HP:0011370)2.55486014
95Chronic mucocutaneous candidiasis (HP:0002728)2.55486014
96Abnormality of purine metabolism (HP:0004352)2.47489559
97Abnormality of eosinophils (HP:0001879)2.46844481
98Pancreatic islet-cell hyperplasia (HP:0004510)2.45269555
99Conjugated hyperbilirubinemia (HP:0002908)2.44474330
100Abnormal protein glycosylation (HP:0012346)2.43331231
101Abnormal glycosylation (HP:0012345)2.43331231
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43331231
103Abnormal protein N-linked glycosylation (HP:0012347)2.43331231
104Disinhibition (HP:0000734)2.41679462
105Congenital glaucoma (HP:0001087)2.40852104
106Facial shape deformation (HP:0011334)2.40368176
107Potter facies (HP:0002009)2.40368176
108Abnormal tarsal ossification (HP:0008369)2.40116484
109Autoimmune hemolytic anemia (HP:0001890)2.39799357
110Gangrene (HP:0100758)2.39375954
111Intrahepatic cholestasis (HP:0001406)2.35636000
112Increased IgM level (HP:0003496)2.35633232
113Carpal bone hypoplasia (HP:0001498)2.35614857
114Abnormality of B cell number (HP:0010975)2.35611878
115Prenatal maternal abnormality (HP:0002686)2.34626756
116Pulmonary embolism (HP:0002204)2.30501328
117Hyperglycinuria (HP:0003108)2.30298581
118Progressive muscle weakness (HP:0003323)2.29237461
119Abnormality of the renal cortex (HP:0011035)2.26104040
120Skin rash (HP:0000988)2.25727284
121Increased serum ferritin (HP:0003281)2.25318241
122Abnormality of dental color (HP:0011073)2.25151735
123Abnormality of glycine metabolism (HP:0010895)2.21345002
124Abnormality of serine family amino acid metabolism (HP:0010894)2.21345002
125Polyneuropathy (HP:0001271)2.21274025
126Long foot (HP:0001833)2.20718925
127Insulin-resistant diabetes mellitus (HP:0000831)2.20143185
128Abnormality of the prostate (HP:0008775)2.18962468
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17839047
130Urticaria (HP:0001025)2.17777060
131Fatigue (HP:0012378)2.16651390
132Hypoplasia of the uterus (HP:0000013)2.16319641
133Acute hepatic failure (HP:0006554)2.16301537
134Optic nerve hypoplasia (HP:0000609)2.14736699
135Pectus carinatum (HP:0000768)2.14338713
136Chest pain (HP:0100749)2.11994856
137Mucopolysacchariduria (HP:0008155)2.11976118
138Urinary glycosaminoglycan excretion (HP:0003541)2.11976118
139Hypergammaglobulinemia (HP:0010702)2.10588933
140Ventricular fibrillation (HP:0001663)2.10527618
141Neonatal death (HP:0003811)2.09492912
142Conjunctival telangiectasia (HP:0000524)2.08837159
143Vacuolated lymphocytes (HP:0001922)2.08719193
144Anorexia (HP:0002039)2.05668299
145Insulin resistance (HP:0000855)2.05586532
146Hypoplasia of the odontoid process (HP:0003311)2.05089965
147Abnormality of the pleura (HP:0002103)2.04860101
148Joint swelling (HP:0001386)2.04231818
149Type II lissencephaly (HP:0007260)2.03463235
150Abnormality of iron homeostasis (HP:0011031)2.02416852
151Hepatosplenomegaly (HP:0001433)2.01098050
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00734151
153Generalized aminoaciduria (HP:0002909)1.99876493
154Cortical visual impairment (HP:0100704)1.99526919
155Tubulointerstitial abnormality (HP:0001969)1.99242758
156Gingival bleeding (HP:0000225)1.98966593
157Progressive neurologic deterioration (HP:0002344)1.96282523
158Arterial thrombosis (HP:0004420)1.95878431
159Systemic lupus erythematosus (HP:0002725)1.95393391
160Abnormality of methionine metabolism (HP:0010901)1.94578413
161Increased IgE level (HP:0003212)1.94282336
162Amelogenesis imperfecta (HP:0000705)1.94247284
163Glomerulopathy (HP:0100820)1.94062359
164Right ventricular cardiomyopathy (HP:0011663)1.93690866
165Hypsarrhythmia (HP:0002521)1.92210611
166Basal ganglia calcification (HP:0002135)1.91889704
167Limb hypertonia (HP:0002509)1.91579424
168Severe short stature (HP:0003510)1.91380434
169Vertigo (HP:0002321)1.90222420
170Abnormality of renin-angiotensin system (HP:0000847)1.89090569
171Myocardial infarction (HP:0001658)1.88508413
172Acute lymphatic leukemia (HP:0006721)1.86823512
173Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86595820
174Gastrointestinal infarctions (HP:0005244)1.86161009
175Abnormality of transition element cation homeostasis (HP:0011030)1.85354722
176Aplasia/hypoplasia of the uterus (HP:0008684)1.85198156
177Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84302900
178Abnormality of polysaccharide metabolism (HP:0011012)1.84302900
179Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84302900
180Sepsis (HP:0100806)1.84201062
181Abnormality of T cell number (HP:0011839)1.82186444
182EEG with generalized epileptiform discharges (HP:0011198)1.81942952
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81355024
184Ankyloglossia (HP:0010296)1.81250399
185Agammaglobulinemia (HP:0004432)1.79641050
186Renal salt wasting (HP:0000127)1.77712571
187Glucose intolerance (HP:0000833)1.77595470
188Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77386921
189Abdominal distention (HP:0003270)1.77061521
190Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76833443
191Abnormal foot bone ossification (HP:0010675)1.75321252
192Prolonged QT interval (HP:0001657)1.73015842
193Methylmalonic aciduria (HP:0012120)1.72738698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.49620435
2ERN15.51678638
3OXSR14.64579894
4MAP4K13.97033627
5INSRR3.94221191
6EIF2AK33.90245829
7MAP2K23.48913118
8RIPK43.20958195
9TRIB33.08557762
10TAOK32.77051539
11PKN22.69609837
12CSF1R2.63136191
13KIT2.55831910
14MAPK152.50261675
15FRK2.48341636
16FES2.43295393
17TNIK2.20841384
18TESK22.13550547
19BLK2.11602839
20SCYL22.08500915
21TNK22.06995453
22BMPR21.92555092
23TXK1.88939040
24SYK1.84972112
25MATK1.82721431
26MAP2K31.77279365
27ZAP701.76005644
28MAPKAPK31.75983657
29IRAK31.64350709
30WNK41.63057752
31ACVR1B1.56063806
32BTK1.56015129
33FLT31.55416550
34PTK61.48838466
35CSK1.44137486
36MAP3K21.42608950
37CDK191.40763569
38TEC1.40418207
39LYN1.39878183
40ADRBK21.39620434
41MAP2K11.38698849
42NME11.37193959
43JAK31.35511410
44PAK21.24313667
45PASK1.22719478
46NME21.22665508
47TYK21.16980443
48FGR1.16126174
49GRK71.14122180
50SIK11.12578699
51MAP3K141.11473679
52IKBKB1.11173079
53LCK1.10109454
54MAP3K111.09815433
55PIK3CG1.09059780
56ITK1.08744096
57HCK1.06593694
58PDGFRB1.02906809
59MAP3K10.99663174
60MARK30.98892692
61DYRK1B0.97692395
62CAMKK20.97311674
63RPS6KB20.96832384
64FGFR40.96436505
65HIPK20.94600304
66RIPK10.90310077
67ABL20.90176399
68EPHB10.87338083
69PRKD30.87237222
70TGFBR20.87024251
71PRKCH0.84562519
72DYRK1A0.82232670
73CAMKK10.80949915
74GRK60.79501012
75ARAF0.77628689
76LATS10.75318698
77PDGFRA0.75267535
78EEF2K0.74934700
79RET0.72377138
80PTK2B0.71868004
81EPHA30.71392597
82NTRK10.70808776
83MTOR0.69507631
84PIM20.68128062
85IKBKE0.67743575
86PIK3CA0.67361101
87SIK30.65737471
88PTK20.64214202
89MET0.63834637
90PRKCI0.60530028
91FER0.60123395
92IRAK20.59476270
93CDK60.58291615
94DAPK20.56685946
95STK390.54516131
96TAOK20.53353915
97MAP2K60.53248763
98JAK20.53053353
99KSR20.52408483
100MAP3K50.50319489
101LRRK20.47475201
102PRKCD0.47342643
103PDPK10.46762545
104RPS6KA60.45897517
105MOS0.44786116
106MAP3K130.44076696
107PBK0.43719133
108IRAK10.43531505
109RPS6KL10.41165504
110RPS6KC10.41165504
111PIM10.39372852
112PRKCZ0.39227553
113PRKD10.38586533
114RPS6KB10.38427910
115TAOK10.38123828
116BMX0.38116044
117IRAK40.34151519
118PRKD20.34014356
119MAP3K60.33803635
120FYN0.32676674
121MAP3K30.31828714
122PRKG20.31814823
123CAMK1D0.31774415
124PDK10.31672512
125PRKCQ0.29197375
126MST1R0.29155590
127MAPK30.29047918
128PKN10.28539315
129GSK3A0.27860626
130TGFBR10.26955616
131FGFR30.26248401
132STK100.24952328
133IGF1R0.24934428
134PDK20.24577977
135MAP4K20.23868588
136PINK10.23271011
137TBK10.23139600
138MAP3K70.23122951
139NEK60.22593419
140UHMK10.22533716
141TLK10.21653848
142PRKACB0.21091310
143GRK10.20830508
144TESK10.20276803
145TSSK60.19449374
146RPS6KA10.18605590
147PRKAA10.18121069
148MAPK10.18120234
149ABL10.18087911
150MAPK120.17710772
151JAK10.17592075
152CDC42BPA0.17279853
153CSNK1A1L0.16797776
154CSNK1G20.16610198
155DAPK10.16342955
156MAPKAPK50.14858203
157KDR0.13383784
158EGFR0.12492446
159ILK0.12288198
160CSNK1A10.11787058
161ERBB20.11455388
162LMTK20.11271012
163PRKACG0.11265675
164MAP3K80.11013438
165MAPK110.10757412
166FGFR20.10273469

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049727.92345351
2Fat digestion and absorption_Homo sapiens_hsa049755.69926486
3Protein digestion and absorption_Homo sapiens_hsa049745.34075285
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.77684825
5Protein export_Homo sapiens_hsa030603.58022644
6Asthma_Homo sapiens_hsa053103.50576152
7Allograft rejection_Homo sapiens_hsa053302.92911214
8Collecting duct acid secretion_Homo sapiens_hsa049662.90868898
9Rheumatoid arthritis_Homo sapiens_hsa053232.90602347
10Folate biosynthesis_Homo sapiens_hsa007902.84241177
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.78239192
12Glycerolipid metabolism_Homo sapiens_hsa005612.75286016
13Staphylococcus aureus infection_Homo sapiens_hsa051502.71958435
14Graft-versus-host disease_Homo sapiens_hsa053322.68113651
15Primary immunodeficiency_Homo sapiens_hsa053402.64655167
16Autoimmune thyroid disease_Homo sapiens_hsa053202.64129715
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.50384557
18Leishmaniasis_Homo sapiens_hsa051402.47409140
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31714116
20Tuberculosis_Homo sapiens_hsa051522.25235134
21Cyanoamino acid metabolism_Homo sapiens_hsa004602.19652947
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18269331
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16070841
24Osteoclast differentiation_Homo sapiens_hsa043802.15232445
25Hematopoietic cell lineage_Homo sapiens_hsa046402.13720219
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03255385
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99158502
28Antigen processing and presentation_Homo sapiens_hsa046121.87418835
29Steroid biosynthesis_Homo sapiens_hsa001001.82128765
30Vitamin digestion and absorption_Homo sapiens_hsa049771.75460977
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.71917933
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64312445
33Phagosome_Homo sapiens_hsa041451.60471542
34Propanoate metabolism_Homo sapiens_hsa006401.56070866
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42389913
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42092151
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41455801
38Renin-angiotensin system_Homo sapiens_hsa046141.38990064
39Malaria_Homo sapiens_hsa051441.38275096
40Herpes simplex infection_Homo sapiens_hsa051681.32619220
41Viral myocarditis_Homo sapiens_hsa054161.30996737
42Pertussis_Homo sapiens_hsa051331.30294656
43Sulfur metabolism_Homo sapiens_hsa009201.29636652
44Base excision repair_Homo sapiens_hsa034101.22203107
45B cell receptor signaling pathway_Homo sapiens_hsa046621.19591696
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15582639
47Ribosome_Homo sapiens_hsa030101.15372964
48Platelet activation_Homo sapiens_hsa046111.10651929
49Linoleic acid metabolism_Homo sapiens_hsa005911.09919939
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09630482
51N-Glycan biosynthesis_Homo sapiens_hsa005101.09142332
52Olfactory transduction_Homo sapiens_hsa047401.08935134
53Selenocompound metabolism_Homo sapiens_hsa004501.07290457
54TNF signaling pathway_Homo sapiens_hsa046681.04379880
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03353254
56Arginine and proline metabolism_Homo sapiens_hsa003301.01832550
57Toxoplasmosis_Homo sapiens_hsa051451.01778485
58Insulin secretion_Homo sapiens_hsa049111.01548957
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01131635
60Shigellosis_Homo sapiens_hsa051310.99265642
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97735902
62African trypanosomiasis_Homo sapiens_hsa051430.96923709
63Chemokine signaling pathway_Homo sapiens_hsa040620.95889809
64Starch and sucrose metabolism_Homo sapiens_hsa005000.92991794
65DNA replication_Homo sapiens_hsa030300.89312538
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86090045
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84564729
68T cell receptor signaling pathway_Homo sapiens_hsa046600.84057294
69Salmonella infection_Homo sapiens_hsa051320.83282407
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82539804
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80641288
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.80255534
73Other glycan degradation_Homo sapiens_hsa005110.79525948
74Biosynthesis of amino acids_Homo sapiens_hsa012300.79176369
75Oxidative phosphorylation_Homo sapiens_hsa001900.78976632
76Synaptic vesicle cycle_Homo sapiens_hsa047210.78484080
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77866380
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76307378
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75031866
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74322729
81Measles_Homo sapiens_hsa051620.74128195
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.73603343
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73537554
84Basal transcription factors_Homo sapiens_hsa030220.73055103
85Systemic lupus erythematosus_Homo sapiens_hsa053220.72549867
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71950749
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71436931
88Acute myeloid leukemia_Homo sapiens_hsa052210.70545941
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.69780785
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69749196
91Vibrio cholerae infection_Homo sapiens_hsa051100.68781032
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67533628
93Epstein-Barr virus infection_Homo sapiens_hsa051690.65469934
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65292205
95Tryptophan metabolism_Homo sapiens_hsa003800.65143662
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63248464
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.62705041
98Fatty acid degradation_Homo sapiens_hsa000710.61463495
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60146617
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57815588
101Influenza A_Homo sapiens_hsa051640.54691204
102beta-Alanine metabolism_Homo sapiens_hsa004100.54529005
103One carbon pool by folate_Homo sapiens_hsa006700.50409879
104Sphingolipid metabolism_Homo sapiens_hsa006000.49384460
105Notch signaling pathway_Homo sapiens_hsa043300.49041256
106Pyruvate metabolism_Homo sapiens_hsa006200.49009314
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48806631
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46115815
109Nitrogen metabolism_Homo sapiens_hsa009100.45115575
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44712508
111Lysosome_Homo sapiens_hsa041420.42439662
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41465486
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.41013748
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40745561
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40538903
116Parkinsons disease_Homo sapiens_hsa050120.40190929
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40028209
118Arginine biosynthesis_Homo sapiens_hsa002200.39708975
119Viral carcinogenesis_Homo sapiens_hsa052030.37985586
120Apoptosis_Homo sapiens_hsa042100.35768826
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35095344
122Glutathione metabolism_Homo sapiens_hsa004800.35020373
123Type I diabetes mellitus_Homo sapiens_hsa049400.32802918
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31725667
125Butanoate metabolism_Homo sapiens_hsa006500.30645487
126Hepatitis B_Homo sapiens_hsa051610.30539393
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30151724
128Fructose and mannose metabolism_Homo sapiens_hsa000510.30147776
129Metabolic pathways_Homo sapiens_hsa011000.29726528
130Regulation of autophagy_Homo sapiens_hsa041400.28953071
131Type II diabetes mellitus_Homo sapiens_hsa049300.28702692
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28658783
133Legionellosis_Homo sapiens_hsa051340.28382564
134Arachidonic acid metabolism_Homo sapiens_hsa005900.27552708
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26873794
136Ether lipid metabolism_Homo sapiens_hsa005650.26564354
137Sulfur relay system_Homo sapiens_hsa041220.26274893
138Bile secretion_Homo sapiens_hsa049760.26062105
139Insulin resistance_Homo sapiens_hsa049310.25622120
140Hepatitis C_Homo sapiens_hsa051600.24771878
141Carbon metabolism_Homo sapiens_hsa012000.24690277
142Nucleotide excision repair_Homo sapiens_hsa034200.23799196
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23449649
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23172880
145Peroxisome_Homo sapiens_hsa041460.22825853
146Fatty acid metabolism_Homo sapiens_hsa012120.22684910
147Amoebiasis_Homo sapiens_hsa051460.22555257
148Phototransduction_Homo sapiens_hsa047440.22546491
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.21255105
150Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21222120
151Histidine metabolism_Homo sapiens_hsa003400.21190647
152Caffeine metabolism_Homo sapiens_hsa002320.20976644
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19763170
154HTLV-I infection_Homo sapiens_hsa051660.19627252
155Endocytosis_Homo sapiens_hsa041440.19360676
156Thyroid hormone synthesis_Homo sapiens_hsa049180.18662977
157Cocaine addiction_Homo sapiens_hsa050300.16947348
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16097053
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16082462
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14061838
161Endometrial cancer_Homo sapiens_hsa052130.12842348
162Alzheimers disease_Homo sapiens_hsa050100.11902625
163Galactose metabolism_Homo sapiens_hsa000520.11602181
164Bladder cancer_Homo sapiens_hsa052190.11402769
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11009528
166Chemical carcinogenesis_Homo sapiens_hsa052040.10732689
167VEGF signaling pathway_Homo sapiens_hsa043700.09510135
168mTOR signaling pathway_Homo sapiens_hsa041500.09134419
169Prostate cancer_Homo sapiens_hsa052150.08726027
170Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07925805
171Prion diseases_Homo sapiens_hsa050200.07789541
172Glycerophospholipid metabolism_Homo sapiens_hsa005640.06470889
173Insulin signaling pathway_Homo sapiens_hsa049100.02862858
174AMPK signaling pathway_Homo sapiens_hsa041520.02711021
175Lysine degradation_Homo sapiens_hsa003100.02412970
176Aldosterone synthesis and secretion_Homo sapiens_hsa049250.02363555
177Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01900547

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