CELA2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)9.82542396
2protein retention in ER lumen (GO:0006621)9.64443316
3membrane lipid catabolic process (GO:0046466)9.58346748
4peptidyl-proline hydroxylation (GO:0019511)9.21841534
5negative regulation of epidermal cell differentiation (GO:0045605)9.14294202
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.63056080
7cholesterol catabolic process (GO:0006707)8.05610039
8sterol catabolic process (GO:0016127)8.05610039
9ceramide catabolic process (GO:0046514)7.46143401
10protein hydroxylation (GO:0018126)7.23679951
11neutrophil mediated immunity (GO:0002446)7.00036959
12negative regulation of epidermis development (GO:0045683)6.97641450
13icosanoid secretion (GO:0032309)6.30047193
14arachidonic acid secretion (GO:0050482)6.30047193
15phosphatidylinositol acyl-chain remodeling (GO:0036149)6.29343869
16daunorubicin metabolic process (GO:0044597)6.04312270
17polyketide metabolic process (GO:0030638)6.04312270
18doxorubicin metabolic process (GO:0044598)6.04312270
19phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.95632416
20phosphatidylserine acyl-chain remodeling (GO:0036150)5.88956269
21aminoglycoside antibiotic metabolic process (GO:0030647)5.55810467
22cholesterol transport (GO:0030301)5.48076908
23sterol transport (GO:0015918)5.48076908
24tetrapyrrole metabolic process (GO:0033013)5.23050514
25fatty acid derivative transport (GO:1901571)5.13992882
26icosanoid transport (GO:0071715)5.13992882
27myeloid leukocyte mediated immunity (GO:0002444)5.08291804
28phospholipid catabolic process (GO:0009395)5.03346956
29regulation of keratinocyte differentiation (GO:0045616)4.95451000
30digestive system process (GO:0022600)4.94506483
31regulation of keratinocyte proliferation (GO:0010837)4.93096022
32sphingolipid catabolic process (GO:0030149)4.81218500
33innate immune response in mucosa (GO:0002227)4.70203735
34leukotriene biosynthetic process (GO:0019370)4.38670898
35phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.22116977
36cellular protein catabolic process (GO:0044257)4.04172398
37water-soluble vitamin metabolic process (GO:0006767)3.90331292
38mucosal immune response (GO:0002385)3.85465583
39phosphatidylserine metabolic process (GO:0006658)3.80610888
40steroid catabolic process (GO:0006706)3.77997701
41endothelial cell migration (GO:0043542)3.64892496
42antibacterial humoral response (GO:0019731)3.63896728
43phosphatidylcholine acyl-chain remodeling (GO:0036151)3.56598841
44organ or tissue specific immune response (GO:0002251)3.54095125
45phosphatidic acid biosynthetic process (GO:0006654)3.42039212
46phosphatidic acid metabolic process (GO:0046473)3.42039212
47defense response to Gram-positive bacterium (GO:0050830)3.35008467
48regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.33361169
49antimicrobial humoral response (GO:0019730)3.31294173
50maintenance of protein localization in organelle (GO:0072595)3.29670898
51nucleotide-sugar biosynthetic process (GO:0009226)3.23151211
52regulation of triglyceride catabolic process (GO:0010896)3.21240353
53alditol phosphate metabolic process (GO:0052646)3.17862591
54leukotriene metabolic process (GO:0006691)3.17644246
55negative regulation of epithelial cell differentiation (GO:0030857)3.15572669
56multicellular organismal catabolic process (GO:0044243)3.13796828
57retinoid metabolic process (GO:0001523)3.10778670
58progesterone metabolic process (GO:0042448)3.04722730
59intestinal cholesterol absorption (GO:0030299)28.0353322
60acute-phase response (GO:0006953)2.99009249
61diterpenoid metabolic process (GO:0016101)2.98969877
62mitochondrial calcium ion transport (GO:0006851)2.97071180
63vitamin metabolic process (GO:0006766)2.96045800
64regulation of epidermal cell differentiation (GO:0045604)2.95112922
65cholesterol metabolic process (GO:0008203)2.92955497
66multicellular organismal metabolic process (GO:0044236)2.92929887
67primary alcohol catabolic process (GO:0034310)2.92044074
68alcohol catabolic process (GO:0046164)2.83330332
69phototransduction, visible light (GO:0007603)2.82119518
70glycoside metabolic process (GO:0016137)2.80600047
71epithelial cell migration (GO:0010631)2.75870685
72phosphatidylglycerol metabolic process (GO:0046471)2.74292624
73regulation of cholesterol homeostasis (GO:2000188)2.70177821
74positive regulation of wound healing (GO:0090303)2.64207086
75sterol metabolic process (GO:0016125)2.63222468
76terpenoid metabolic process (GO:0006721)2.63083915
77glycine transport (GO:0015816)2.62092155
78L-alpha-amino acid transmembrane transport (GO:1902475)2.58946233
79extracellular matrix disassembly (GO:0022617)2.52216294
80detection of visible light (GO:0009584)2.43719127
81regulation of acrosome reaction (GO:0060046)2.42688911
82regulation of oxidative stress-induced cell death (GO:1903201)2.42477181
83lipid catabolic process (GO:0016042)2.39292964
84organic hydroxy compound transport (GO:0015850)2.38376428
85fatty acid derivative biosynthetic process (GO:1901570)2.35692709
86icosanoid biosynthetic process (GO:0046456)2.35692709
87UDP-N-acetylglucosamine metabolic process (GO:0006047)2.34490611
88long-chain fatty acid transport (GO:0015909)2.28718321
89isoprenoid metabolic process (GO:0006720)2.26342069
90phototransduction (GO:0007602)2.25141609
91macroautophagy (GO:0016236)2.23910056
92negative regulation of hormone metabolic process (GO:0032351)2.20381191
93retinal metabolic process (GO:0042574)2.15525546
94imidazole-containing compound metabolic process (GO:0052803)2.12448581
95organic hydroxy compound catabolic process (GO:1901616)2.12235754
96digestion (GO:0007586)18.7425396
97cobalamin metabolic process (GO:0009235)15.6253562
98transcytosis (GO:0045056)13.0885772
99intestinal absorption (GO:0050892)13.0535434
100glycolipid catabolic process (GO:0019377)10.3127889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.76688730
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.44573473
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.44573473
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.44573473
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.43425651
6EGR1_19032775_ChIP-ChIP_M12_Human2.78181069
7GATA4_25053715_ChIP-Seq_YYC3_Human2.56492701
8PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.45318194
9HTT_18923047_ChIP-ChIP_STHdh_Human2.31486030
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat14.7360529
11GATA6_25053715_ChIP-Seq_YYC3_Human1.89211485
12ERG_21242973_ChIP-ChIP_JURKAT_Human1.82021614
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.75430777
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.60650560
15TAF15_26573619_Chip-Seq_HEK293_Human1.59895514
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57370304
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56931168
18* NFYA_21822215_ChIP-Seq_K562_Human1.55322822
19* ETV1_20927104_ChIP-Seq_GIST48_Human1.53987571
20PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.53259922
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48275097
22* HNFA_21074721_ChIP-Seq_CACO-2_Human1.47413098
23* PHF8_20622853_ChIP-Seq_HELA_Human1.43004381
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.41715556
25* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.39262376
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.38370202
27* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37665287
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37412143
29* GATA6_21074721_ChIP-Seq_CACO-2_Human1.35505894
30* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34888205
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34744816
32ESET_19884257_ChIP-Seq_ESCs_Mouse1.33781190
33* RBPJ_21746931_ChIP-Seq_IB4_Human1.31342444
34FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29690915
35* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29335117
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.28346662
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.27421054
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26188592
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23390955
40* NFYB_21822215_ChIP-Seq_K562_Human1.22533218
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21022129
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19577568
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.19136032
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.17779933
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.13127580
46PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12520303
47CBP_21632823_ChIP-Seq_H3396_Human1.10951754
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09777978
49TAF2_19829295_ChIP-Seq_ESCs_Human1.09473065
50SOX2_20726797_ChIP-Seq_SW620_Human1.09421456
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01998714
52CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01439222
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00732816
54GATA1_22025678_ChIP-Seq_K562_Human0.99434927
55P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98845043
56P300_19829295_ChIP-Seq_ESCs_Human0.98249792
57ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97655413
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96458160
59* TBL1_22424771_ChIP-Seq_293T_Human0.92512845
60GATA3_24758297_ChIP-Seq_MCF-7_Human0.91834785
61GATA3_21867929_ChIP-Seq_CD8_Mouse0.91587490
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90989647
63LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89347278
64PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88559434
65SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88035400
66ERA_21632823_ChIP-Seq_H3396_Human0.87696140
67FLI1_21867929_ChIP-Seq_CD8_Mouse0.87115952
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86519206
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86338817
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85898585
71FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85550980
72TP53_18474530_ChIP-ChIP_U2OS_Human0.85319291
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84125627
74GATA1_26923725_Chip-Seq_HPCs_Mouse0.83855157
75AR_20517297_ChIP-Seq_VCAP_Human0.83016451
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82286733
77VDR_22108803_ChIP-Seq_LS180_Human0.80430155
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79748735
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79148178
80SA1_27219007_Chip-Seq_Bcells_Human0.78760191
81CDX2_22108803_ChIP-Seq_LS180_Human0.78673106
82FOXA2_19822575_ChIP-Seq_HepG2_Human0.77647595
83LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76911999
84REST_21632747_ChIP-Seq_MESCs_Mouse0.75286947
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75214757
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.75178690
87* CEBPB_22108803_ChIP-Seq_LS180_Human0.73782518
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72470869
89CJUN_26792858_Chip-Seq_BT549_Human0.70969525
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70856701
91RUNX2_22187159_ChIP-Seq_PCA_Human0.70546668
92ETS1_21867929_ChIP-Seq_TH2_Mouse0.70264176
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69685067
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.69474126
95CBP_20019798_ChIP-Seq_JUKART_Human0.69474126
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.68542929
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.68512103
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67780492
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.66986738
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.66596571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition9.66887906
2MP0005365_abnormal_bile_salt8.04425158
3MP0003959_abnormal_lean_body4.47233240
4MP0005220_abnormal_exocrine_pancreas3.32749042
5MP0005083_abnormal_biliary_tract2.28356175
6MP0005448_abnormal_energy_balance2.07095810
7MP0001666_abnormal_nutrient_absorption13.7400635
8MP0005085_abnormal_gallbladder_physiolo1.79154878
9MP0010234_abnormal_vibrissa_follicle1.75969802
10MP0002693_abnormal_pancreas_physiology1.71004386
11MP0003300_gastrointestinal_ulcer1.69502759
12MP0002118_abnormal_lipid_homeostasis1.60782210
13MP0010386_abnormal_urinary_bladder1.36422032
14MP0005452_abnormal_adipose_tissue1.26357564
15MP0002138_abnormal_hepatobiliary_system1.25386354
16MP0000613_abnormal_salivary_gland1.18952510
17MP0010329_abnormal_lipoprotein_level1.13758048
18MP0004264_abnormal_extraembryonic_tissu1.02014088
19MP0002078_abnormal_glucose_homeostasis0.99770588
20MP0005084_abnormal_gallbladder_morpholo0.96507609
21MP0003953_abnormal_hormone_level0.94507628
22MP0001501_abnormal_sleep_pattern0.86393135
23MP0000598_abnormal_liver_morphology0.86127857
24MP0003045_fibrosis0.81752292
25MP0002163_abnormal_gland_morphology0.77839636
26MP0008004_abnormal_stomach_pH0.76910988
27MP0010678_abnormal_skin_adnexa0.74687364
28MP0003195_calcinosis0.72995661
29MP0003943_abnormal_hepatobiliary_system0.71381692
30MP0001944_abnormal_pancreas_morphology0.69219297
31MP0003252_abnormal_bile_duct0.68130881
32MP0003950_abnormal_plasma_membrane0.66461103
33MP0003878_abnormal_ear_physiology0.65365315
34MP0005377_hearing/vestibular/ear_phenot0.65365315
35MP0005334_abnormal_fat_pad0.64712267
36MP0002876_abnormal_thyroid_physiology0.64156064
37MP0002132_abnormal_respiratory_system0.60049324
38MP0001502_abnormal_circadian_rhythm0.59799257
39MP0009780_abnormal_chondrocyte_physiolo0.59235170
40MP0001664_abnormal_digestion0.58749366
41MP0002928_abnormal_bile_duct0.56577312
42MP0000462_abnormal_digestive_system0.55912598
43MP0000537_abnormal_urethra_morphology0.53990878
44MP0001731_abnormal_postnatal_growth0.52050254
45MP0002139_abnormal_hepatobiliary_system0.51736783
46MP0002277_abnormal_respiratory_mucosa0.46838959
47MP0002970_abnormal_white_adipose0.46766803
48MP0003879_abnormal_hair_cell0.46706017
49MP0008995_early_reproductive_senescence0.46176038
50MP0008872_abnormal_physiological_respon0.45953979
51MP0002089_abnormal_postnatal_growth/wei0.45867763
52MP0001756_abnormal_urination0.45390525
53MP0002909_abnormal_adrenal_gland0.43492494
54MP0003283_abnormal_digestive_organ0.43245837
55MP0000013_abnormal_adipose_tissue0.41540447
56MP0004043_abnormal_pH_regulation0.41121195
57MP0008875_abnormal_xenobiotic_pharmacok0.40895436
58MP0004019_abnormal_vitamin_homeostasis0.39003394
59MP0005332_abnormal_amino_acid0.38015525
60MP0003123_paternal_imprinting0.38002471
61MP0000383_abnormal_hair_follicle0.35001546
62MP0009384_cardiac_valve_regurgitation0.34816632
63MP0005319_abnormal_enzyme/_coenzyme0.34168226
64MP0002168_other_aberrant_phenotype0.31925680
65MP0001765_abnormal_ion_homeostasis0.31890315
66MP0000538_abnormal_urinary_bladder0.31656392
67MP0009840_abnormal_foam_cell0.31122242
68MP0000470_abnormal_stomach_morphology0.30171518
69MP0002098_abnormal_vibrissa_morphology0.29672746
70MP0005410_abnormal_fertilization0.29503708
71MP0009642_abnormal_blood_homeostasis0.29276210
72MP0009643_abnormal_urine_homeostasis0.28891728
73MP0005379_endocrine/exocrine_gland_phen0.28882489
74MP0000367_abnormal_coat/_hair0.27738771
75MP0005636_abnormal_mineral_homeostasis0.27339459
76MP0001845_abnormal_inflammatory_respons0.27292508
77MP0003656_abnormal_erythrocyte_physiolo0.27064423
78MP0003011_delayed_dark_adaptation0.26455779
79MP0003329_amyloid_beta_deposits0.26180414
80MP0001485_abnormal_pinna_reflex0.25916294
81MP0003866_abnormal_defecation0.24519828
82MP0000003_abnormal_adipose_tissue0.24261505
83MP0008961_abnormal_basal_metabolism0.23774378
84MP0000747_muscle_weakness0.23603142
85MP0004233_abnormal_muscle_weight0.22080434
86MP0005451_abnormal_body_composition0.21946287
87MP0009764_decreased_sensitivity_to0.21016562
88MP0002009_preneoplasia0.20287021
89MP0005646_abnormal_pituitary_gland0.16602766
90MP0002127_abnormal_cardiovascular_syste0.16590905
91MP0003956_abnormal_body_size0.16528072
92MP0002638_abnormal_pupillary_reflex0.15138450
93MP0002069_abnormal_eating/drinking_beha0.14369118
94MP0000858_altered_metastatic_potential0.13983515
95MP0001177_atelectasis0.13910889
96MP0002796_impaired_skin_barrier0.13861923
97MP0008770_decreased_survivor_rate0.13827118
98MP0003828_pulmonary_edema0.13289266
99MP0005395_other_phenotype0.13102543
100MP0006138_congestive_heart_failure0.13082084

Predicted human phenotypes

RankGene SetZ-score
1Tetraparesis (HP:0002273)5.70223181
2Pancreatitis (HP:0001733)4.96135536
3Abnormality of the pleura (HP:0002103)3.74071082
4Hydroxyprolinuria (HP:0003080)3.50480144
5Abnormality of proline metabolism (HP:0010907)3.50480144
6Type II lissencephaly (HP:0007260)3.26936424
7Cerebellar dysplasia (HP:0007033)3.16789551
8Anal atresia (HP:0002023)3.06419495
9Male infertility (HP:0003251)3.04898431
10Steatorrhea (HP:0002570)20.8923021
11Abnormality of the pons (HP:0007361)2.98222197
12Abnormal pancreas size (HP:0012094)2.73396289
13Sex reversal (HP:0012245)2.72143325
14Abnormal sex determination (HP:0012244)2.72143325
15Ileus (HP:0002595)2.64883828
16Large for gestational age (HP:0001520)2.55660443
17Paraparesis (HP:0002385)2.42998512
18Hypoplasia of the pons (HP:0012110)2.42723516
19Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41816622
20Popliteal pterygium (HP:0009756)2.40510632
21Vascular calcification (HP:0004934)2.40081810
22Type I transferrin isoform profile (HP:0003642)2.24082691
23Reduced antithrombin III activity (HP:0001976)2.13605774
24Rectal prolapse (HP:0002035)2.07064970
25Cardiovascular calcification (HP:0011915)2.03766954
26Abnormality of methionine metabolism (HP:0010901)2.00013995
27Fat malabsorption (HP:0002630)16.1366756
28Hypoproteinemia (HP:0003075)11.3326660
29Exocrine pancreatic insufficiency (HP:0001738)10.9221658
30Neoplasm of the heart (HP:0100544)1.96831600
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90978651
32Abnormal protein N-linked glycosylation (HP:0012347)1.90978651
33Abnormal protein glycosylation (HP:0012346)1.90978651
34Abnormal glycosylation (HP:0012345)1.90978651
35Skin pits (HP:0100276)1.84670433
36Abnormal biliary tract morphology (HP:0012440)1.84490987
37Lower limb hyperreflexia (HP:0002395)1.78839863
38Abnormality of the nasal septum (HP:0000419)1.78015015
39Abnormality of the intrinsic pathway (HP:0010989)1.77380734
40Preauricular pit (HP:0004467)1.72075295
41Periauricular skin pits (HP:0100277)1.72075295
42Abnormality of alanine metabolism (HP:0010916)1.66883886
43Hyperalaninemia (HP:0003348)1.66883886
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66883886
45Tubulointerstitial fibrosis (HP:0005576)1.66675589
46Esophageal varix (HP:0002040)1.53935232
47Azoospermia (HP:0000027)1.53325011
48Abnormality of the common coagulation pathway (HP:0010990)1.50126361
49Abnormality of sulfur amino acid metabolism (HP:0004339)1.50030835
50Abnormal tarsal ossification (HP:0008369)1.49934421
51Stenosis of the external auditory canal (HP:0000402)1.46807448
52Deformed sella turcica (HP:0002681)1.44638121
53Congenital, generalized hypertrichosis (HP:0004540)1.42564081
54Villous atrophy (HP:0011473)1.41804303
55Abnormality of small intestinal villus morphology (HP:0011472)1.41804303
56Abnormality of transition element cation homeostasis (HP:0011030)1.41712133
57Abnormality of aspartate family amino acid metabolism (HP:0010899)1.41529372
58Malnutrition (HP:0004395)1.41525396
59Severe muscular hypotonia (HP:0006829)1.40952363
60Dyskinesia (HP:0100660)1.39713597
61Insulin-resistant diabetes mellitus (HP:0000831)1.39121373
62Glossoptosis (HP:0000162)1.39092074
63Ketoacidosis (HP:0001993)1.38694874
64Right ventricular cardiomyopathy (HP:0011663)1.38044893
65Hyperinsulinemic hypoglycemia (HP:0000825)1.35344009
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.34474662
67Ureteral duplication (HP:0000073)1.33772504
68Hypercalciuria (HP:0002150)1.31027708
69Portal hypertension (HP:0001409)1.29645427
70Lissencephaly (HP:0001339)1.29541310
71Genetic anticipation (HP:0003743)1.28023873
72Papillary thyroid carcinoma (HP:0002895)1.27961710
73Chronic hepatic failure (HP:0100626)1.27449262
74Enlarged kidneys (HP:0000105)1.24827946
75Abnormality of the hepatic vasculature (HP:0006707)1.22906077
76Brushfield spots (HP:0001088)1.22648619
77Congenital primary aphakia (HP:0007707)1.22266841
78Hyperglycemia (HP:0003074)1.22072295
79Down-sloping shoulders (HP:0200021)1.22047560
80Abdominal pain (HP:0002027)1.21648592
81Medial flaring of the eyebrow (HP:0010747)1.21110695
82Facial shape deformation (HP:0011334)1.19781361
83Potter facies (HP:0002009)1.19781361
84Abnormality of the Achilles tendon (HP:0005109)1.19727853
85Tubulointerstitial abnormality (HP:0001969)1.18854291
86Muscular dystrophy (HP:0003560)1.16784669
87Abnormality of the distal phalanges of the toes (HP:0010182)1.16720162
88Abnormality of alkaline phosphatase activity (HP:0004379)1.15211734
89Absent eyebrow (HP:0002223)1.15032194
90Curly hair (HP:0002212)1.14725038
91Achilles tendon contracture (HP:0001771)1.14405026
92Elevated alkaline phosphatase (HP:0003155)1.14395006
93Gait imbalance (HP:0002141)1.14332608
94Short 4th metacarpal (HP:0010044)1.13629885
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.13629885
96Intrahepatic cholestasis (HP:0001406)1.12700437
97Abnormality of the vitreous humor (HP:0004327)1.12600788
98Increased CSF protein (HP:0002922)1.12114780
99Bifid uvula (HP:0000193)1.11400489
100Vertebral compression fractures (HP:0002953)1.10588515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.60754733
2EPHA25.68804573
3EIF2AK34.37130156
4PDK23.82020587
5MAP3K33.20276194
6EPHA33.02249165
7TAOK32.67595567
8NME12.64993227
9MAP3K22.64678496
10FRK2.21588952
11NTRK32.10892723
12GRK11.98837100
13BMPR1B1.73448238
14IRAK11.67560278
15INSRR1.61314467
16MAPKAPK31.49456095
17MAPK151.46897795
18ERBB41.41708660
19EPHB11.36022992
20PRKG21.32319858
21TBK11.31070730
22ERN11.26246143
23MST1R1.26115313
24STK391.25652490
25MAP3K121.15691854
26NLK1.14850655
27IRAK21.12138562
28SCYL21.04563119
29NEK61.00706607
30DAPK21.00260526
31BCKDK0.98053356
32MAP2K20.93682513
33FER0.93325290
34TRIB30.92025955
35MAP3K40.89112345
36EIF2AK10.87310512
37PKN20.85933657
38ACVR1B0.81661301
39STK160.81159300
40TRPM70.80488420
41MAP2K10.79846409
42CDK190.77734853
43PIM20.77010964
44EEF2K0.73228071
45PRKD30.71818586
46PRKCE0.71673342
47PDPK10.71269257
48MAP3K70.70662758
49RIPK10.70439565
50MST40.69029239
51ERBB30.66702621
52SGK30.61945889
53SGK20.56628384
54ROCK10.51364426
55JAK10.50983309
56MUSK0.50116839
57WNK40.49800550
58MAP3K50.48829650
59OXSR10.47661497
60MET0.47272672
61CAMK40.47110928
62PRKAA10.46865041
63BCR0.46239064
64TGFBR10.45264801
65RPS6KB20.41285044
66ILK0.40201452
67MAP3K10.39675826
68PAK30.39537670
69PRKD20.39394250
70PASK0.36061549
71SGK4940.34637904
72SGK2230.34637904
73PDK10.34600025
74TAOK10.33932042
75KSR10.32108092
76MAP3K90.29797694
77STK380.28447038
78PTK60.27687542
79FGFR30.27183886
80AKT20.26804679
81MELK0.25975580
82CDK80.25833578
83TAOK20.25583671
84RPS6KB10.23393545
85CCNB10.22881894
86RET0.20386055
87MYLK0.20036519
88MAPK10.19882689
89CSNK1G10.19842102
90YES10.18893078
91ADRBK20.18399284
92BMX0.18166693
93MAP4K20.17245145
94BMPR20.16842772
95PRKCA0.16095309
96RAF10.15992378
97MAP2K60.15370796
98PAK20.14328807
99PRKACA0.13281174
100ADRBK10.12264689

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049758.47875788
2* Protein digestion and absorption_Homo sapiens_hsa049746.20216611
3Glycerolipid metabolism_Homo sapiens_hsa005614.32704875
4Vitamin digestion and absorption_Homo sapiens_hsa049772.44316401
5Steroid biosynthesis_Homo sapiens_hsa001002.20099398
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11017345
7Starch and sucrose metabolism_Homo sapiens_hsa005002.04877603
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.00060058
9* Pancreatic secretion_Homo sapiens_hsa0497210.2333531
10Renin-angiotensin system_Homo sapiens_hsa046141.92833012
11Linoleic acid metabolism_Homo sapiens_hsa005911.65713616
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.41828258
13Ether lipid metabolism_Homo sapiens_hsa005650.98529441
14Arachidonic acid metabolism_Homo sapiens_hsa005900.81122205
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66429118
16Influenza A_Homo sapiens_hsa051640.64262191
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60222967
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60112796
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59422637
20Histidine metabolism_Homo sapiens_hsa003400.56852126
21Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56754768
22Circadian rhythm_Homo sapiens_hsa047100.46924596
23Vitamin B6 metabolism_Homo sapiens_hsa007500.41640073
24Steroid hormone biosynthesis_Homo sapiens_hsa001400.40291506
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40022899
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39557928
27Selenocompound metabolism_Homo sapiens_hsa004500.38331007
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34808682
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31869954
30Protein export_Homo sapiens_hsa030600.30230837
31Sulfur metabolism_Homo sapiens_hsa009200.30129910
32Glutathione metabolism_Homo sapiens_hsa004800.29653009
33Chemical carcinogenesis_Homo sapiens_hsa052040.27543789
34N-Glycan biosynthesis_Homo sapiens_hsa005100.27390782
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.24390428
36Metabolic pathways_Homo sapiens_hsa011000.23750616
37Glycerophospholipid metabolism_Homo sapiens_hsa005640.23380893
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22746086
39Sulfur relay system_Homo sapiens_hsa041220.21858958
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21420956
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19598756
42Bile secretion_Homo sapiens_hsa049760.19116512
43Retinol metabolism_Homo sapiens_hsa008300.16639025
44Notch signaling pathway_Homo sapiens_hsa043300.16041024
45Tryptophan metabolism_Homo sapiens_hsa003800.15863225
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15267146
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14627947
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.14386075
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.14371254
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11810167
51Arginine and proline metabolism_Homo sapiens_hsa003300.11394400
52ABC transporters_Homo sapiens_hsa020100.11307758
53Ovarian steroidogenesis_Homo sapiens_hsa049130.11016802
54Tight junction_Homo sapiens_hsa045300.08777373
55Phototransduction_Homo sapiens_hsa047440.08235745
56Sphingolipid metabolism_Homo sapiens_hsa006000.07174158
57Nitrogen metabolism_Homo sapiens_hsa009100.06282030
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.05537764
59Fatty acid degradation_Homo sapiens_hsa000710.05184391
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04613853
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03762914
62Hepatitis C_Homo sapiens_hsa051600.03581347
63Vibrio cholerae infection_Homo sapiens_hsa051100.02432815
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02275622
65beta-Alanine metabolism_Homo sapiens_hsa004100.01745040
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.00446102
67Thyroid cancer_Homo sapiens_hsa05216-0.1375102
68FoxO signaling pathway_Homo sapiens_hsa04068-0.1336016
69Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.1328231
70Regulation of autophagy_Homo sapiens_hsa04140-0.1319809
71Lysine degradation_Homo sapiens_hsa00310-0.1306180
72Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1295665
73TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1285852
74Other glycan degradation_Homo sapiens_hsa00511-0.1235082
75Endometrial cancer_Homo sapiens_hsa05213-0.1230643
76Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.1208260
77HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1194683
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.1164220
79Hippo signaling pathway_Homo sapiens_hsa04390-0.1149692
80ErbB signaling pathway_Homo sapiens_hsa04012-0.1111709
81TNF signaling pathway_Homo sapiens_hsa04668-0.1062131
82Caffeine metabolism_Homo sapiens_hsa00232-0.1015555
83Propanoate metabolism_Homo sapiens_hsa00640-0.0948468
84Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0918875
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0855818
86Complement and coagulation cascades_Homo sapiens_hsa04610-0.0776838
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0748686
88Arginine biosynthesis_Homo sapiens_hsa00220-0.0725463
89Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0668017
90Peroxisome_Homo sapiens_hsa04146-0.0530700
91Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0425881
92Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0409820
93Ras signaling pathway_Homo sapiens_hsa04014-0.0333582
94Adherens junction_Homo sapiens_hsa04520-0.0284749
95Butanoate metabolism_Homo sapiens_hsa00650-0.0247549
96Mineral absorption_Homo sapiens_hsa04978-0.0221073
97Galactose metabolism_Homo sapiens_hsa00052-0.0191543
98Insulin secretion_Homo sapiens_hsa04911-0.0052868
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0050852
100Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0030151

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