CELA3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of epidermis development (GO:0045683)8.89989304
2cobalamin metabolic process (GO:0009235)8.04317728
3phosphatidylinositol acyl-chain remodeling (GO:0036149)7.63134484
4transcytosis (GO:0045056)7.44055278
5cholesterol catabolic process (GO:0006707)7.43468762
6sterol catabolic process (GO:0016127)7.43468762
7negative regulation of digestive system process (GO:0060457)7.31986295
8phosphatidylserine acyl-chain remodeling (GO:0036150)7.29569457
9peptidyl-proline hydroxylation (GO:0019511)7.21836606
10phosphatidylglycerol acyl-chain remodeling (GO:0036148)7.20789235
11cysteine metabolic process (GO:0006534)7.12081846
12regulation of phospholipase A2 activity (GO:0032429)6.98687139
13glycolipid catabolic process (GO:0019377)6.51337598
14intestinal absorption (GO:0050892)6.49778299
15icosanoid transport (GO:0071715)6.48263126
16fatty acid derivative transport (GO:1901571)6.48263126
17proline biosynthetic process (GO:0006561)6.46991486
18regulation of keratinocyte differentiation (GO:0045616)6.41711533
19regulation of keratinocyte proliferation (GO:0010837)6.14171934
20innate immune response in mucosa (GO:0002227)6.12978240
21branched-chain amino acid catabolic process (GO:0009083)5.99092487
22membrane lipid catabolic process (GO:0046466)5.89109718
23serine family amino acid biosynthetic process (GO:0009070)5.62469482
24cellular modified amino acid catabolic process (GO:0042219)5.53062420
25protein hydroxylation (GO:0018126)5.46829609
26valine metabolic process (GO:0006573)5.39865173
27phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.19231944
28mitochondrial calcium ion transport (GO:0006851)5.19044509
29branched-chain amino acid metabolic process (GO:0009081)5.17351271
30ceramide catabolic process (GO:0046514)5.02813482
31protein maturation by protein folding (GO:0022417)5.01837076
32aspartate family amino acid catabolic process (GO:0009068)5.01545562
33mucosal immune response (GO:0002385)4.99921024
34positive regulation of heat generation (GO:0031652)4.99068181
35zinc ion transport (GO:0006829)4.96748807
36polyketide metabolic process (GO:0030638)4.91952410
37doxorubicin metabolic process (GO:0044598)4.91952410
38daunorubicin metabolic process (GO:0044597)4.91952410
39cellular protein catabolic process (GO:0044257)4.89263921
40phosphatidylserine metabolic process (GO:0006658)4.87514628
41leukotriene biosynthetic process (GO:0019370)4.84347547
42homocysteine metabolic process (GO:0050667)4.82011062
43regulation of fever generation (GO:0031620)4.77707308
44regulation of acrosome reaction (GO:0060046)4.73384793
45L-serine metabolic process (GO:0006563)4.72720187
46COPI coating of Golgi vesicle (GO:0048205)4.72653298
47Golgi transport vesicle coating (GO:0048200)4.72653298
48cholesterol transport (GO:0030301)4.63429955
49sterol transport (GO:0015918)4.63429955
50digestive system process (GO:0022600)4.60209886
51organ or tissue specific immune response (GO:0002251)4.55413368
52acute-phase response (GO:0006953)4.53152392
53phosphatidylcholine acyl-chain remodeling (GO:0036151)4.50687867
54GDP-mannose metabolic process (GO:0019673)4.49969292
55activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.49903406
56serine family amino acid metabolic process (GO:0009069)4.49223691
57proline metabolic process (GO:0006560)4.48240829
58aminoglycoside antibiotic metabolic process (GO:0030647)4.44527726
59glutamine metabolic process (GO:0006541)4.42300628
60signal peptide processing (GO:0006465)4.41058197
61response to endoplasmic reticulum stress (GO:0034976)4.40534381
62creatine metabolic process (GO:0006600)4.36409547
634-hydroxyproline metabolic process (GO:0019471)4.34071251
64positive regulation of nuclease activity (GO:0032075)4.30675317
65neutrophil mediated immunity (GO:0002446)4.23445826
66phosphatidic acid biosynthetic process (GO:0006654)4.22678640
67phosphatidic acid metabolic process (GO:0046473)4.22678640
68maintenance of protein localization in organelle (GO:0072595)4.21641291
69L-phenylalanine catabolic process (GO:0006559)4.18438642
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.18438642
71endoplasmic reticulum unfolded protein response (GO:0030968)4.12905739
72water-soluble vitamin metabolic process (GO:0006767)4.11012573
73intestinal epithelial cell development (GO:0060576)4.09813515
74coenzyme catabolic process (GO:0009109)4.08609287
75glycine metabolic process (GO:0006544)4.06621498
76defense response to Gram-positive bacterium (GO:0050830)4.03539816
77cellular response to unfolded protein (GO:0034620)4.02014889
78alditol phosphate metabolic process (GO:0052646)4.00086408
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97586558
80L-phenylalanine metabolic process (GO:0006558)3.97586558
81mitochondrion distribution (GO:0048311)3.93357250
82regulation of nuclease activity (GO:0032069)3.91928294
83cellular response to topologically incorrect protein (GO:0035967)3.85716975
84regulation of heat generation (GO:0031650)3.83016166
85ER-nucleus signaling pathway (GO:0006984)3.79929785
86steroid catabolic process (GO:0006706)3.79078924
87regulation of epidermal cell differentiation (GO:0045604)3.75063090
88sulfur amino acid biosynthetic process (GO:0000097)3.72386947
89negative regulation of epithelial cell differentiation (GO:0030857)3.70230045
90leukotriene metabolic process (GO:0006691)3.66948689
91ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.64936720
92retinoic acid receptor signaling pathway (GO:0048384)3.64083969
93alpha-amino acid biosynthetic process (GO:1901607)3.56504513
94retina layer formation (GO:0010842)3.48662672
95phospholipid catabolic process (GO:0009395)3.47363450
96antibacterial humoral response (GO:0019731)3.45160122
97positive regulation of wound healing (GO:0090303)3.44506618
98cell redox homeostasis (GO:0045454)3.37822869
99endothelial cell migration (GO:0043542)3.37087628
100phosphatidylglycerol metabolic process (GO:0046471)3.35164326
101COPII vesicle coating (GO:0048208)3.34462761
102response to unfolded protein (GO:0006986)3.30942028
103icosanoid secretion (GO:0032309)3.28870662
104arachidonic acid secretion (GO:0050482)3.28870662
105glycine transport (GO:0015816)3.28521956
106protein N-linked glycosylation via asparagine (GO:0018279)3.27414487
107biotin metabolic process (GO:0006768)3.25825688
108multicellular organismal catabolic process (GO:0044243)3.25591020
109negative regulation of cell fate commitment (GO:0010454)3.25279997
110aspartate family amino acid metabolic process (GO:0009066)3.25135666
111peptidyl-asparagine modification (GO:0018196)3.24528067
112myeloid leukocyte mediated immunity (GO:0002444)3.21425981
113maintenance of gastrointestinal epithelium (GO:0030277)3.21167807
114regulation of cholesterol homeostasis (GO:2000188)3.20971680
115response to topologically incorrect protein (GO:0035966)3.20818016
116sphingolipid catabolic process (GO:0030149)3.20150547
117polarized epithelial cell differentiation (GO:0030859)3.19834362
118antimicrobial humoral response (GO:0019730)3.19062484
119acute inflammatory response (GO:0002526)3.18636220
120endocrine pancreas development (GO:0031018)3.17599560
121retinoid metabolic process (GO:0001523)3.16704012
122regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.14518635
123glutamine family amino acid biosynthetic process (GO:0009084)3.11675400
124vitamin metabolic process (GO:0006766)3.10229511
125sulfur amino acid catabolic process (GO:0000098)3.09209176
126regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.08772671
127cellular amino acid catabolic process (GO:0009063)3.05990023
128multicellular organismal metabolic process (GO:0044236)3.01253820
129one-carbon metabolic process (GO:0006730)3.01203152
130tetrapyrrole metabolic process (GO:0033013)3.00794972
131nucleotide-sugar biosynthetic process (GO:0009226)3.00067919
132protein N-linked glycosylation (GO:0006487)2.99728170
133diterpenoid metabolic process (GO:0016101)2.98612298
134peptidyl-proline modification (GO:0018208)2.97670127
135cellular amino acid biosynthetic process (GO:0008652)2.96968047
136ER overload response (GO:0006983)2.95493129
137pancreas development (GO:0031016)2.94414710
138regulation of oxidative stress-induced cell death (GO:1903201)2.93071551
139regulation of calcium ion import (GO:0090279)2.92814334
140peptide catabolic process (GO:0043171)2.92685597
141L-alpha-amino acid transmembrane transport (GO:1902475)2.89862311
142negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.89097033
143cellular response to cadmium ion (GO:0071276)2.87012675
144cellular response to zinc ion (GO:0071294)2.86559009
145lysine metabolic process (GO:0006553)2.83943277
146phototransduction, visible light (GO:0007603)2.83731190
147icosanoid biosynthetic process (GO:0046456)2.81921100
148fatty acid derivative biosynthetic process (GO:1901570)2.81921100
149extracellular matrix disassembly (GO:0022617)2.80564470
150cellular glucuronidation (GO:0052695)2.77680990
151long-chain fatty acid transport (GO:0015909)2.71964745
152atrioventricular valve morphogenesis (GO:0003181)2.70285529
153regulation of macrophage chemotaxis (GO:0010758)2.65804398
154glucuronate metabolic process (GO:0019585)2.65095763
155uronic acid metabolic process (GO:0006063)2.65095763
156terpenoid metabolic process (GO:0006721)2.63447515
157negative regulation of hormone metabolic process (GO:0032351)2.62971954
158calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.59355460
159neutrophil chemotaxis (GO:0030593)2.52459997
160progesterone metabolic process (GO:0042448)2.50775372
161positive regulation of calcium ion transport into cytosol (GO:0010524)2.49080690
162epithelial cell migration (GO:0010631)2.47321778
163neutrophil migration (GO:1990266)2.46629074
164regulation of triglyceride catabolic process (GO:0010896)2.39899993
165exocrine pancreas development (GO:0031017)17.7448804
166intestinal cholesterol absorption (GO:0030299)15.4455383
167protein retention in ER lumen (GO:0006621)12.5732819
168* digestion (GO:0007586)12.5344076
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.6787222
170negative regulation of epidermal cell differentiation (GO:0045605)11.6586047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.99833209
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.57536932
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.96323110
4ERG_21242973_ChIP-ChIP_JURKAT_Human3.76848097
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.55050782
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.13247302
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.01962899
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.83366908
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.65782116
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.64501381
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61128219
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45450607
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.44178424
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.44178424
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.44178424
16GATA4_25053715_ChIP-Seq_YYC3_Human2.25263928
17TCF4_18268006_ChIP-ChIP_LS174T_Human2.20978565
18PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.20079382
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13847462
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12779665
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10089992
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04377934
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.02298275
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89821006
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88026749
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81434901
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.80095146
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.74251658
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72277441
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71634595
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62575828
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62403486
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62246135
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59637344
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.59180858
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57139620
37* GATA6_25053715_ChIP-Seq_YYC3_Human1.55586360
38FOXA1_25552417_ChIP-Seq_VCAP_Human1.52408186
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52059023
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.47640732
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46728927
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46057690
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.42896987
44IRF1_19129219_ChIP-ChIP_H3396_Human1.41276159
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.38092880
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36743741
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34504203
48P68_20966046_ChIP-Seq_HELA_Human1.33258201
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32291302
50* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.29570010
51LXR_22292898_ChIP-Seq_THP-1_Human1.29505033
52* ETV1_20927104_ChIP-Seq_GIST48_Human1.28149392
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27170392
54ESET_19884257_ChIP-Seq_ESCs_Mouse1.26580472
55EGR1_19032775_ChIP-ChIP_M12_Human1.26055707
56* HNFA_21074721_ChIP-Seq_CACO-2_Human1.24094588
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23557587
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22446693
59CHD1_26751641_Chip-Seq_LNCaP_Human1.21765831
60TAF2_19829295_ChIP-Seq_ESCs_Human1.21558916
61ERA_21632823_ChIP-Seq_H3396_Human1.20783891
62* PHF8_20622853_ChIP-Seq_HELA_Human1.19354959
63* NFYA_21822215_ChIP-Seq_K562_Human1.17992652
64* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17382080
65ETS1_21867929_ChIP-Seq_TH2_Mouse1.17128850
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17026851
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16948336
68CREB1_26743006_Chip-Seq_LNCaP_Human1.16752803
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16046932
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.15524664
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15432210
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14862069
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14208057
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13453843
75* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12345864
76OCT4_20526341_ChIP-Seq_ESCs_Human1.12139723
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11229904
78CJUN_26792858_Chip-Seq_BT549_Human1.10996082
79ERG_20517297_ChIP-Seq_VCAP_Human1.10703392
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10642711
81* GATA6_21074721_ChIP-Seq_CACO-2_Human1.10576377
82* RBPJ_21746931_ChIP-Seq_IB4_Human1.10534984
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09286316
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06703166
85* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06385818
86* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04289940
87P53_21459846_ChIP-Seq_SAOS-2_Human1.04279417
88BCOR_27268052_Chip-Seq_Bcells_Human1.03974413
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.03947190
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03384786
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03068717
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.02584034
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01784918
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01686098
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00393465
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99970865
97ETS1_20019798_ChIP-Seq_JURKAT_Human0.99580414
98GATA1_22025678_ChIP-Seq_K562_Human0.99358555
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.99096660
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98050668
101FOXH1_21741376_ChIP-Seq_ESCs_Human0.97985980
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97739333
103SOX2_20726797_ChIP-Seq_SW620_Human0.97697301
104CBP_21632823_ChIP-Seq_H3396_Human0.97462384
105ATF3_27146783_Chip-Seq_COLON_Human0.97066338
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96929996
107P300_19829295_ChIP-Seq_ESCs_Human0.96841834
108* NFYB_21822215_ChIP-Seq_K562_Human0.96153573
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96102857
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95558409
111EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95025420
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94959482
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94449249
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.93822890
115* TP63_22573176_ChIP-Seq_HFKS_Human0.93410685
116FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92407685
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.91663425
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91384048
119CTCF_20526341_ChIP-Seq_ESCs_Human0.91273607
120SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.90722322
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90326075
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89643146
123TP53_18474530_ChIP-ChIP_U2OS_Human0.88869340
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88516824
125CDX2_22108803_ChIP-Seq_LS180_Human0.88350316
126CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88174298
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87689273
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85571735
129* SA1_27219007_Chip-Seq_Bcells_Human0.84530459
130HTT_18923047_ChIP-ChIP_STHdh_Human0.84487098
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84095614
132KLF4_19829295_ChIP-Seq_ESCs_Human0.83389455
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82779735
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82749504
135MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82281486
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82247968
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82247968
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81716420
139* CTCF_27219007_Chip-Seq_Bcells_Human0.81555851
140CEBPB_22108803_ChIP-Seq_LS180_Human0.81163794
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81121376
142SOX2_22085726_ChIP-Seq_NPCs_Mouse0.80926137
143AR_20517297_ChIP-Seq_VCAP_Human0.80912966
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80074861
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79693078
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78812855
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78739398
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78254069
149LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78121199
150SOX2_19829295_ChIP-Seq_ESCs_Human0.77828628
151NANOG_19829295_ChIP-Seq_ESCs_Human0.77828628
152RUNX_20019798_ChIP-Seq_JUKART_Human0.77386461
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.76811798
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.76604499
155CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76041461
156SOX2_21211035_ChIP-Seq_LN229_Human0.75689367
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75226449
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75226449
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75118316
160MYC_19829295_ChIP-Seq_ESCs_Human0.74948229
161GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74351347
162KLF5_20875108_ChIP-Seq_MESCs_Mouse0.73405733
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.73243047
164CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70467320
165SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.69726515
166* TBL1_22424771_ChIP-Seq_293T_Human0.68135187
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.66753132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.66514879
2MP0001666_abnormal_nutrient_absorption9.13498945
3MP0005220_abnormal_exocrine_pancreas7.19140980
4MP0005365_abnormal_bile_salt6.70231363
5MP0005084_abnormal_gallbladder_morpholo4.74963027
6MP0003868_abnormal_feces_composition4.46778546
7MP0005085_abnormal_gallbladder_physiolo3.55752815
8MP0001664_abnormal_digestion2.74214910
9MP0002693_abnormal_pancreas_physiology2.69425521
10MP0003959_abnormal_lean_body2.42583074
11MP0010386_abnormal_urinary_bladder2.32199723
12MP0005451_abnormal_body_composition1.97791567
13MP0003705_abnormal_hypodermis_morpholog1.90201391
14MP0002277_abnormal_respiratory_mucosa1.86536844
15MP0002139_abnormal_hepatobiliary_system1.83394811
16MP0004233_abnormal_muscle_weight1.80135516
17MP0003300_gastrointestinal_ulcer1.70697388
18MP0003638_abnormal_response/metabolism_1.69742380
19MP0001944_abnormal_pancreas_morphology1.66667595
20MP0005448_abnormal_energy_balance1.60668715
21MP0005332_abnormal_amino_acid1.59450920
22MP0004264_abnormal_extraembryonic_tissu1.48315379
23MP0002118_abnormal_lipid_homeostasis1.43021986
24MP0003195_calcinosis1.29719240
25MP0010234_abnormal_vibrissa_follicle1.25798563
26MP0001873_stomach_inflammation1.23531581
27MP0005165_increased_susceptibility_to1.17515946
28MP0009780_abnormal_chondrocyte_physiolo1.15183508
29MP0000470_abnormal_stomach_morphology1.06717707
30MP0009840_abnormal_foam_cell1.00377152
31MP0005408_hypopigmentation0.98248532
32MP0005360_urolithiasis0.97302681
33MP0003806_abnormal_nucleotide_metabolis0.97282646
34MP0000490_abnormal_crypts_of0.96761424
35MP0005535_abnormal_body_temperature0.95510826
36MP0002078_abnormal_glucose_homeostasis0.95395136
37MP0002132_abnormal_respiratory_system0.93968020
38MP0000003_abnormal_adipose_tissue0.93957993
39MP0008438_abnormal_cutaneous_collagen0.92892776
40MP0001764_abnormal_homeostasis0.90760882
41MP0003011_delayed_dark_adaptation0.89889123
42MP0009643_abnormal_urine_homeostasis0.88245666
43MP0003186_abnormal_redox_activity0.84876848
44MP0008789_abnormal_olfactory_epithelium0.83136816
45MP0010352_gastrointestinal_tract_polyps0.79972297
46MP0003943_abnormal_hepatobiliary_system0.77927052
47MP0001663_abnormal_digestive_system0.77806563
48MP0006036_abnormal_mitochondrial_physio0.76523503
49MP0003045_fibrosis0.75534725
50MP0009765_abnormal_xenobiotic_induced0.74570491
51MP0003950_abnormal_plasma_membrane0.74317470
52MP0003953_abnormal_hormone_level0.68694547
53MP0001756_abnormal_urination0.67356520
54MP0002163_abnormal_gland_morphology0.67125346
55MP0005058_abnormal_lysosome_morphology0.65888184
56MP0005452_abnormal_adipose_tissue0.65518773
57MP0010329_abnormal_lipoprotein_level0.64938215
58MP0000613_abnormal_salivary_gland0.64540249
59MP0000750_abnormal_muscle_regeneration0.64293774
60MP0009384_cardiac_valve_regurgitation0.63585415
61MP0002089_abnormal_postnatal_growth/wei0.63452563
62MP0005394_taste/olfaction_phenotype0.63104544
63MP0005499_abnormal_olfactory_system0.63104544
64MP0002909_abnormal_adrenal_gland0.62368985
65MP0000462_abnormal_digestive_system0.61294533
66MP0003252_abnormal_bile_duct0.60750749
67MP0010678_abnormal_skin_adnexa0.57563775
68MP0005381_digestive/alimentary_phenotyp0.57483601
69MP0003283_abnormal_digestive_organ0.57152410
70MP0001845_abnormal_inflammatory_respons0.55074980
71MP0005319_abnormal_enzyme/_coenzyme0.54695316
72MP0002098_abnormal_vibrissa_morphology0.54421215
73MP0001502_abnormal_circadian_rhythm0.54358159
74MP0000598_abnormal_liver_morphology0.52001392
75MP0008004_abnormal_stomach_pH0.51907383
76MP0002876_abnormal_thyroid_physiology0.50453011
77MP0001731_abnormal_postnatal_growth0.50427622
78MP0002796_impaired_skin_barrier0.48814472
79MP0008872_abnormal_physiological_respon0.48789167
80MP0001348_abnormal_lacrimal_gland0.48596699
81MP0000609_abnormal_liver_physiology0.46691419
82MP0003329_amyloid_beta_deposits0.44446051
83MP0002138_abnormal_hepatobiliary_system0.42496354
84MP0005375_adipose_tissue_phenotype0.41576718
85MP0001501_abnormal_sleep_pattern0.39940926
86MP0003795_abnormal_bone_structure0.38852978
87MP0001485_abnormal_pinna_reflex0.38682651
88MP0000955_abnormal_spinal_cord0.38042330
89MP0005334_abnormal_fat_pad0.36973299
90MP0003656_abnormal_erythrocyte_physiolo0.36838174
91MP0005386_behavior/neurological_phenoty0.36482507
92MP0004924_abnormal_behavior0.36482507
93MP0005379_endocrine/exocrine_gland_phen0.36430178
94MP0000371_diluted_coat_color0.35419210
95MP0000778_abnormal_nervous_system0.35324026
96MP0004043_abnormal_pH_regulation0.35035568
97MP0000367_abnormal_coat/_hair0.35008797
98MP0006054_spinal_hemorrhage0.33052041
99MP0000377_abnormal_hair_follicle0.32777097
100MP0008469_abnormal_protein_level0.32692393
101MP0009642_abnormal_blood_homeostasis0.32212625
102MP0001765_abnormal_ion_homeostasis0.31947902
103MP0004019_abnormal_vitamin_homeostasis0.31765240
104MP0008961_abnormal_basal_metabolism0.31607854
105MP0003879_abnormal_hair_cell0.31456994
106MP0002060_abnormal_skin_morphology0.29305436
107MP0005636_abnormal_mineral_homeostasis0.29048395
108MP0002069_abnormal_eating/drinking_beha0.29035156
109MP0003956_abnormal_body_size0.28808966
110MP0009333_abnormal_splenocyte_physiolog0.28383369
111MP0003866_abnormal_defecation0.28067089
112MP0003566_abnormal_cell_adhesion0.27875698
113MP0005595_abnormal_vascular_smooth0.27580394
114MP0005166_decreased_susceptibility_to0.27367278
115MP0003436_decreased_susceptibility_to0.26911148
116MP0002168_other_aberrant_phenotype0.26892671
117MP0000647_abnormal_sebaceous_gland0.26418375
118MP0003763_abnormal_thymus_physiology0.25010648
119MP0000858_altered_metastatic_potential0.24765303
120MP0008995_early_reproductive_senescence0.24692232
121MP0005248_abnormal_Harderian_gland0.23278710
122MP0003091_abnormal_cell_migration0.23203786
123MP0002928_abnormal_bile_duct0.22710616
124MP0004142_abnormal_muscle_tone0.22699090
125MP0004185_abnormal_adipocyte_glucose0.22105685
126MP0008875_abnormal_xenobiotic_pharmacok0.21843435
127MP0009763_increased_sensitivity_to0.20931047
128MP0008770_decreased_survivor_rate0.20616125
129MP0002136_abnormal_kidney_physiology0.19252227
130MP0003183_abnormal_peptide_metabolism0.18837130
131MP0003948_abnormal_gas_homeostasis0.18191015
132MP0002970_abnormal_white_adipose0.17871165
133MP0005670_abnormal_white_adipose0.17645834
134MP0000538_abnormal_urinary_bladder0.17370564
135MP0000579_abnormal_nail_morphology0.17319219
136MP0003191_abnormal_cellular_cholesterol0.16716684
137MP0000920_abnormal_myelination0.16349924
138MP0005164_abnormal_response_to0.16332015
139MP0005584_abnormal_enzyme/coenzyme_acti0.16192059
140MP0004147_increased_porphyrin_level0.15592046
141MP0005410_abnormal_fertilization0.14524156

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.09274068
2Short chin (HP:0000331)7.61439601
3Decreased subcutaneous fat (HP:0001002)7.01016603
4Fat malabsorption (HP:0002630)6.57753366
5Type I diabetes mellitus (HP:0100651)6.35843682
6Abnormality of subcutaneous fat tissue (HP:0001001)6.22334038
7Maternal diabetes (HP:0009800)5.77302430
8Abnormality of the intrinsic pathway (HP:0010989)5.17281282
9Gout (HP:0001997)5.06315878
10Hypoplasia of the pons (HP:0012110)4.61547676
11Abnormality of the pleura (HP:0002103)4.50633935
12Joint stiffness (HP:0001387)4.46873811
13Exocrine pancreatic insufficiency (HP:0001738)4.42583849
14Abnormality of the pons (HP:0007361)4.38913266
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.37324783
16Ketosis (HP:0001946)3.97782648
17Pancreatitis (HP:0001733)3.92933519
18Premature skin wrinkling (HP:0100678)3.87851382
19Cortical dysplasia (HP:0002539)3.78706115
20Optic nerve hypoplasia (HP:0000609)3.72407836
21Hyperglycinemia (HP:0002154)3.60835726
22Hypoproteinemia (HP:0003075)3.52294934
23Ketoacidosis (HP:0001993)3.41098320
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.24091558
25Prenatal maternal abnormality (HP:0002686)3.23277586
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.22824234
27Abnormal protein N-linked glycosylation (HP:0012347)3.22824234
28Abnormal protein glycosylation (HP:0012346)3.22824234
29Abnormal glycosylation (HP:0012345)3.22824234
30Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.19085894
31Tubulointerstitial nephritis (HP:0001970)3.18081591
32Abnormality of glycine metabolism (HP:0010895)3.07547846
33Abnormality of serine family amino acid metabolism (HP:0010894)3.07547846
34Hyperglycinuria (HP:0003108)3.05461792
35Long foot (HP:0001833)3.03263077
36Anal atresia (HP:0002023)3.01948404
37Abnormality of the common coagulation pathway (HP:0010990)3.00869703
38Tetraparesis (HP:0002273)2.91041741
39Abnormality of methionine metabolism (HP:0010901)2.87118243
40Reduced antithrombin III activity (HP:0001976)2.80610320
41Methylmalonic aciduria (HP:0012120)2.77175618
42Large for gestational age (HP:0001520)2.75685866
43Carpal bone hypoplasia (HP:0001498)2.74540567
44Opisthotonus (HP:0002179)2.72335717
45Acute encephalopathy (HP:0006846)2.65910456
46Progressive muscle weakness (HP:0003323)2.65161550
47Hypoglycemic coma (HP:0001325)2.63534649
48Pectus carinatum (HP:0000768)2.61698572
49Abnormal pancreas size (HP:0012094)2.60504024
50Cerebral edema (HP:0002181)2.51302662
51Fatigue (HP:0012378)2.48678754
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43120007
53Abnormality of the pancreatic islet cells (HP:0006476)2.42796144
54Abnormality of endocrine pancreas physiology (HP:0012093)2.42796144
55Homocystinuria (HP:0002156)2.39685702
56Abnormality of homocysteine metabolism (HP:0010919)2.39685702
57Tubulointerstitial fibrosis (HP:0005576)2.39285052
58Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.35121587
59Type II lissencephaly (HP:0007260)2.31137364
60Vacuolated lymphocytes (HP:0001922)2.30479852
61Redundant skin (HP:0001582)2.28616575
62Abnormal sex determination (HP:0012244)2.27252739
63Sex reversal (HP:0012245)2.27252739
64Increased purine levels (HP:0004368)2.26544135
65Hyperuricemia (HP:0002149)2.26544135
66Dicarboxylic aciduria (HP:0003215)2.24065073
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24065073
68Infantile muscular hypotonia (HP:0008947)2.19665652
69Hypoglycemic seizures (HP:0002173)2.18487208
70Hyperammonemia (HP:0001987)2.15908908
71Type I transferrin isoform profile (HP:0003642)2.15675706
72Male infertility (HP:0003251)2.15172006
73Acute hepatic failure (HP:0006554)2.15076752
74Congenital glaucoma (HP:0001087)2.14097144
75Myocardial infarction (HP:0001658)2.10535933
76Lethargy (HP:0001254)2.10441675
77Vascular calcification (HP:0004934)2.08250958
78Ileus (HP:0002595)2.06988796
79Abnormal tarsal ossification (HP:0008369)2.06927578
80Thoracic kyphosis (HP:0002942)2.04734161
81Large hands (HP:0001176)2.04714678
82Rectal prolapse (HP:0002035)2.04581444
83Cortical visual impairment (HP:0100704)2.04400145
84Arterial tortuosity (HP:0005116)1.99735325
85Dysostosis multiplex (HP:0000943)1.99471468
86Right ventricular cardiomyopathy (HP:0011663)1.98611971
87Hyperinsulinemic hypoglycemia (HP:0000825)1.98588758
88Hypoplasia of the odontoid process (HP:0003311)1.98068458
89Hypokinesia (HP:0002375)1.96008115
90Abnormality of the nasal septum (HP:0000419)1.93658085
91Hydroxyprolinuria (HP:0003080)1.93652825
92Abnormality of proline metabolism (HP:0010907)1.93652825
93Popliteal pterygium (HP:0009756)1.91937859
94Acute necrotizing encephalopathy (HP:0006965)1.91236874
95Beaking of vertebral bodies (HP:0004568)1.89305219
96Cardiovascular calcification (HP:0011915)1.88861335
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86823640
98Abnormality of serum amino acid levels (HP:0003112)1.84684804
99Vascular tortuosity (HP:0004948)1.82764765
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81804221
101Abnormal biliary tract morphology (HP:0012440)1.79703590
102Hypsarrhythmia (HP:0002521)1.78968033
103Athetosis (HP:0002305)1.78827405
104Insulin-resistant diabetes mellitus (HP:0000831)1.76799804
105Lower limb hyperreflexia (HP:0002395)1.76397946
106Esophageal varix (HP:0002040)1.76069789
107Absent eyelashes (HP:0000561)1.75260294
108Abnormal mitochondria in muscle tissue (HP:0008316)1.74657333
109Abdominal pain (HP:0002027)1.70510772
110Barrel-shaped chest (HP:0001552)1.70255316
111EEG with generalized epileptiform discharges (HP:0011198)1.69420048
112Hyperphosphatemia (HP:0002905)1.69107998
113Abnormality of the thoracic spine (HP:0100711)1.68519447
114Small epiphyses (HP:0010585)1.67465399
115Malignant hyperthermia (HP:0002047)1.65542798
116Abnormality of the lumbar spine (HP:0100712)1.65253814
117Cerebellar dysplasia (HP:0007033)1.64578271
118Methylmalonic acidemia (HP:0002912)1.64253435
119Abnormality of fatty-acid metabolism (HP:0004359)1.63962237
120Lactic acidosis (HP:0003128)1.62852627
121Vomiting (HP:0002013)1.62073881
122Epileptiform EEG discharges (HP:0011182)1.62019163
123Biconcave vertebral bodies (HP:0004586)1.61276632
124Paraparesis (HP:0002385)1.59916810
125Malnutrition (HP:0004395)1.59551109
126Late onset (HP:0003584)1.54543707
127Stenosis of the external auditory canal (HP:0000402)1.52014590
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.51691408
129Abnormality of small intestinal villus morphology (HP:0011472)1.50069006
130Villous atrophy (HP:0011473)1.50069006
131Abnormality of vitamin B metabolism (HP:0004340)1.49110435
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.47048119
133Abnormality of vitamin metabolism (HP:0100508)1.45875061
134Portal hypertension (HP:0001409)1.45802153
135Glomerulonephritis (HP:0000099)1.43532108
136Absent eyebrow (HP:0002223)1.42694773
137Congenital, generalized hypertrichosis (HP:0004540)1.42125041
138Facial shape deformation (HP:0011334)1.41165734
139Potter facies (HP:0002009)1.41165734
140Hyperglycemia (HP:0003074)1.39847735
141Neoplasm of the pancreas (HP:0002894)1.38517228
142Tubulointerstitial abnormality (HP:0001969)1.38311017
143Unilateral renal agenesis (HP:0000122)1.37151247
144Bifid uvula (HP:0000193)1.36764778
145Goiter (HP:0000853)1.36212452
146Glossoptosis (HP:0000162)1.34347620
147Increased CSF protein (HP:0002922)1.32866144
148Abnormality of the hepatic vasculature (HP:0006707)1.31550047
149Abnormal hemoglobin (HP:0011902)1.26959244
150Symptomatic seizures (HP:0011145)1.23700380
151Enlarged kidneys (HP:0000105)1.22233241
152Azoospermia (HP:0000027)1.22060112
153Aplasia/hypoplasia of the uterus (HP:0008684)1.21612936
154Abnormal cartilage morphology (HP:0002763)1.20873726
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.18932910
156Multiple enchondromatosis (HP:0005701)1.17412103
157Preauricular pit (HP:0004467)1.16977806
158Periauricular skin pits (HP:0100277)1.16977806
159Abnormality of the right ventricle (HP:0001707)1.16579838
160Skin pits (HP:0100276)1.16557407
161Gowers sign (HP:0003391)1.13473126
162Double outlet right ventricle (HP:0001719)1.12268794
163Congenital malformation of the right heart (HP:0011723)1.12268794
164Abnormality of urine glucose concentration (HP:0011016)1.11428624
165Glycosuria (HP:0003076)1.11428624
166Insulin resistance (HP:0000855)1.10951754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.04496888
2ERN16.02223047
3EPHA24.17937538
4MAP2K23.94177991
5EIF2AK33.75976927
6MAP3K33.26882536
7PKN23.05089293
8TRIB32.71708375
9GRK12.41012492
10OXSR12.31236996
11NME12.21321954
12MAPKAPK32.16558122
13EPHA32.04157500
14BCKDK11.2094910
15MAP3K121.95538530
16TGFBR21.94553347
17NME21.87241235
18SCYL21.78864423
19INSRR1.77194366
20ZAP701.66772163
21PAK21.66747991
22MAP2K11.57555986
23IRAK11.45965718
24MST41.42211869
25NLK1.37296941
26PIK3CG1.34477397
27RPS6KB21.32547140
28IRAK31.30858898
29PRKG21.28239628
30DYRK1A1.22074747
31STK241.21845879
32PASK1.21175507
33FRK1.17779517
34RIPK11.12529294
35WNK41.12305629
36EEF2K1.07648109
37FLT31.06183423
38CAMKK11.04458806
39STK38L1.00266636
40BMPR1B0.98931426
41EPHB10.94394983
42PRKCE0.89388279
43PIK3CA0.89078796
44STK160.86704147
45TRIM280.86380043
46PTK60.85747074
47DAPK20.83560300
48TRPM70.83080263
49BRSK20.82010138
50SGK30.81065749
51CAMKK20.79053398
52ERBB40.77980454
53STK390.76394152
54PDGFRB0.75716276
55MAPK150.72410743
56MAP2K60.72332205
57SGK20.72009249
58MET0.70455840
59ERBB30.69164127
60CDK80.67066154
61MAPK120.65643761
62DYRK1B0.63762112
63PINK10.63601055
64FGFR30.63196823
65IRAK40.62674850
66STK30.62320274
67SRPK10.61177654
68MAP3K90.59805053
69IRAK20.57476245
70PDK20.56963071
71RPS6KB10.56042435
72DYRK20.54254979
73MAP3K50.53702935
74MTOR0.51966088
75MELK0.51811848
76PRKCZ0.51765187
77MYLK0.51476436
78JAK10.50711219
79PDPK10.50127284
80ROCK10.49761120
81SIK10.48007135
82PDK10.47521950
83SGK2230.47311531
84SGK4940.47311531
85CDK190.46480634
86BRAF0.45213407
87TAOK30.44781345
88PRKCI0.44037495
89NEK90.43259879
90ICK0.41509888
91STK380.41508421
92PRKCH0.39586671
93PRKCQ0.38544092
94PRKACB0.37018673
95TESK10.36767631
96ILK0.36714252
97CASK0.35261432
98FGFR40.35157153
99PRKAA10.35041994
100RET0.34202609
101MAPK30.33482290
102BCR0.33167914
103PIM20.33112469
104PAK30.32853626
105CAMK1D0.32802354
106NEK60.30677614
107TBK10.30617116
108KSR20.30547679
109CHUK0.30407706
110MUSK0.30312836
111MAP3K10.30029086
112NTRK10.29846413
113LATS10.28072009
114MAPK70.26860495
115MAP3K140.26434315
116HIPK20.26308080
117PRKAA20.25287347
118LRRK20.24530684
119ADRBK20.23161205
120PDK30.22043270
121PDK40.22043270
122TAOK10.20465061
123RPS6KA10.20263102
124MAP3K80.19880928
125RAF10.19695035
126YES10.19522200
127IKBKE0.18076610
128DAPK10.17724927
129MAPK110.16995919
130MAP3K20.16973365
131MAP2K40.16686488
132ABL10.16063011
133JAK20.15925233
134NTRK30.15315293
135ACVR1B0.15293788
136ROCK20.15029666
137BMX0.14979072
138EIF2AK10.14444939
139BMPR20.14306053
140MAP3K70.12950765
141FES0.12073562
142TYRO30.11949535
143DAPK30.11859831
144TAOK20.11318680
145MAPK10.11003398
146MST1R0.10452110
147MOS0.10371366
148FER0.10186842
149GRK50.10013610
150PRKACA0.09087789
151CDK50.08365828
152IGF1R0.08282102
153CSNK1G30.07935705
154ABL20.07300457
155PRKD10.07076859
156CSNK1E0.07025913
157DDR20.06756560
158AKT10.04959474
159EGFR0.04486473
160GRK70.03946856
161CSNK1A10.03412550
162MATK0.02393719

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049727.71603405
2Fat digestion and absorption_Homo sapiens_hsa049755.64559318
3* Protein digestion and absorption_Homo sapiens_hsa049744.93661493
4Protein export_Homo sapiens_hsa030603.71744622
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.48322387
6Folate biosynthesis_Homo sapiens_hsa007903.38169011
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.24041170
8Glycerolipid metabolism_Homo sapiens_hsa005612.75184579
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.61060128
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39205174
11Propanoate metabolism_Homo sapiens_hsa006402.16994385
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12332273
13Steroid biosynthesis_Homo sapiens_hsa001001.74749371
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63373510
15Vitamin digestion and absorption_Homo sapiens_hsa049771.60897903
16Arginine and proline metabolism_Homo sapiens_hsa003301.55744151
17Renin-angiotensin system_Homo sapiens_hsa046141.42673679
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39461200
19Biosynthesis of amino acids_Homo sapiens_hsa012301.30408185
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17894516
21Linoleic acid metabolism_Homo sapiens_hsa005911.17499369
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16053665
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.12216434
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11824556
25N-Glycan biosynthesis_Homo sapiens_hsa005101.06232783
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.00117045
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93467429
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92876260
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91623472
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87698980
31Selenocompound metabolism_Homo sapiens_hsa004500.87348211
32One carbon pool by folate_Homo sapiens_hsa006700.85162205
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84080002
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81270611
35beta-Alanine metabolism_Homo sapiens_hsa004100.81267358
36Other glycan degradation_Homo sapiens_hsa005110.77942078
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75462628
38Influenza A_Homo sapiens_hsa051640.73908774
39Pyruvate metabolism_Homo sapiens_hsa006200.73433418
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71734073
41Circadian rhythm_Homo sapiens_hsa047100.71353996
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69891573
43Parkinsons disease_Homo sapiens_hsa050120.69327897
44Sulfur metabolism_Homo sapiens_hsa009200.63800694
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63056738
46Arginine biosynthesis_Homo sapiens_hsa002200.62629077
47Sulfur relay system_Homo sapiens_hsa041220.62234940
48Notch signaling pathway_Homo sapiens_hsa043300.62173489
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61780681
50Starch and sucrose metabolism_Homo sapiens_hsa005000.60954154
51Vibrio cholerae infection_Homo sapiens_hsa051100.60385614
52Glutathione metabolism_Homo sapiens_hsa004800.56981112
53Fatty acid degradation_Homo sapiens_hsa000710.56129427
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53210387
55Oxidative phosphorylation_Homo sapiens_hsa001900.52796557
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.52572650
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52468798
58Alzheimers disease_Homo sapiens_hsa050100.51873105
59Arachidonic acid metabolism_Homo sapiens_hsa005900.50381446
60Carbon metabolism_Homo sapiens_hsa012000.50336419
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48099770
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47381994
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46042097
64Metabolic pathways_Homo sapiens_hsa011000.45067855
65Tryptophan metabolism_Homo sapiens_hsa003800.44706374
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44171006
67Insulin secretion_Homo sapiens_hsa049110.43472987
68Fructose and mannose metabolism_Homo sapiens_hsa000510.43312055
69Legionellosis_Homo sapiens_hsa051340.38079679
70Mineral absorption_Homo sapiens_hsa049780.36745856
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31837738
72Retinol metabolism_Homo sapiens_hsa008300.31096301
73Ether lipid metabolism_Homo sapiens_hsa005650.28735940
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26603533
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25947576
76Ribosome_Homo sapiens_hsa030100.25686338
77Calcium signaling pathway_Homo sapiens_hsa040200.25183806
78Peroxisome_Homo sapiens_hsa041460.24237165
79Hepatitis C_Homo sapiens_hsa051600.23311108
80Fatty acid metabolism_Homo sapiens_hsa012120.22397246
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.22361300
82Regulation of autophagy_Homo sapiens_hsa041400.21854391
83Lysosome_Homo sapiens_hsa041420.19583780
84Chemical carcinogenesis_Homo sapiens_hsa052040.18740151
85Sphingolipid metabolism_Homo sapiens_hsa006000.17391147
86Tight junction_Homo sapiens_hsa045300.16172682
87Nitrogen metabolism_Homo sapiens_hsa009100.15008634
88Complement and coagulation cascades_Homo sapiens_hsa046100.14114046
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.14033545
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13244964
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13099882
92Huntingtons disease_Homo sapiens_hsa050160.12928076
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12483406
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11605961
95Butanoate metabolism_Homo sapiens_hsa006500.11181589
96Histidine metabolism_Homo sapiens_hsa003400.10930007
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10822547
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.09149918
99Adherens junction_Homo sapiens_hsa045200.07351663
100VEGF signaling pathway_Homo sapiens_hsa043700.06940371
101Vitamin B6 metabolism_Homo sapiens_hsa007500.06421285
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06371565
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05584629
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04580850
105Endometrial cancer_Homo sapiens_hsa052130.04180160
106Ras signaling pathway_Homo sapiens_hsa040140.03149024
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03056483
108TGF-beta signaling pathway_Homo sapiens_hsa043500.02684108
109TNF signaling pathway_Homo sapiens_hsa046680.01902595
110Phototransduction_Homo sapiens_hsa047440.01623572
111Bile secretion_Homo sapiens_hsa049760.01446106
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.00523084
113Galactose metabolism_Homo sapiens_hsa000520.00267266
114ABC transporters_Homo sapiens_hsa020100.00144711
115Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1229884
116HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1224943
117Insulin resistance_Homo sapiens_hsa04931-0.1139839
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.1049292
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1049266
120Hippo signaling pathway_Homo sapiens_hsa04390-0.1048106
121Proteasome_Homo sapiens_hsa03050-0.0997715
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0802467
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040-0.0794895
124Rheumatoid arthritis_Homo sapiens_hsa05323-0.0700822
125Fatty acid elongation_Homo sapiens_hsa00062-0.0653091
126Phenylalanine metabolism_Homo sapiens_hsa00360-0.0650678
127Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0486787
128NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0448080
129Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0375380
130Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0368675
131Pentose phosphate pathway_Homo sapiens_hsa00030-0.0328527
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0317275
133Viral myocarditis_Homo sapiens_hsa05416-0.0279452
134Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0257681
135FoxO signaling pathway_Homo sapiens_hsa04068-0.0224710
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0162913

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »