CELA3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)8.34872341
2intestinal absorption (GO:0050892)8.31883751
3cholesterol catabolic process (GO:0006707)7.54435802
4sterol catabolic process (GO:0016127)7.54435802
5phosphatidylinositol acyl-chain remodeling (GO:0036149)7.33961313
6cobalamin metabolic process (GO:0009235)7.32200566
7Golgi transport vesicle coating (GO:0048200)7.08551844
8COPI coating of Golgi vesicle (GO:0048205)7.08551844
9phosphatidylserine acyl-chain remodeling (GO:0036150)6.94034383
10peptidyl-proline hydroxylation (GO:0019511)6.79110720
11phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.78182591
12negative regulation of digestive system process (GO:0060457)6.27115752
13glycolipid catabolic process (GO:0019377)6.05847162
14membrane lipid catabolic process (GO:0046466)6.01116408
15tetrapyrrole metabolic process (GO:0033013)5.83981084
16regulation of phospholipase A2 activity (GO:0032429)5.83838616
17daunorubicin metabolic process (GO:0044597)5.70964893
18polyketide metabolic process (GO:0030638)5.70964893
19doxorubicin metabolic process (GO:0044598)5.70964893
20myeloid leukocyte mediated immunity (GO:0002444)5.67797358
21cysteine metabolic process (GO:0006534)5.60431212
22icosanoid transport (GO:0071715)5.58844782
23fatty acid derivative transport (GO:1901571)5.58844782
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.53401967
25ceramide catabolic process (GO:0046514)5.50306130
26positive regulation of nuclease activity (GO:0032075)5.28707043
27protein maturation by protein folding (GO:0022417)5.28407171
28protein hydroxylation (GO:0018126)5.24492676
29proline biosynthetic process (GO:0006561)5.19758364
30aminoglycoside antibiotic metabolic process (GO:0030647)5.15706720
31phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.05660953
32regulation of keratinocyte differentiation (GO:0045616)5.02335918
33endoplasmic reticulum unfolded protein response (GO:0030968)4.89981587
34innate immune response in mucosa (GO:0002227)4.87577952
35regulation of keratinocyte proliferation (GO:0010837)4.87035226
36valine metabolic process (GO:0006573)4.85621148
37regulation of nuclease activity (GO:0032069)4.80841147
38response to endoplasmic reticulum stress (GO:0034976)4.76931892
39endocrine pancreas development (GO:0031018)4.76775953
40cellular response to unfolded protein (GO:0034620)4.75600947
41branched-chain amino acid catabolic process (GO:0009083)4.71055725
42ER-nucleus signaling pathway (GO:0006984)4.53179037
43cellular response to topologically incorrect protein (GO:0035967)4.52356562
44COPII vesicle coating (GO:0048208)4.45771594
45phospholipid catabolic process (GO:0009395)4.44405613
46zinc ion transport (GO:0006829)4.42141961
47intestinal epithelial cell development (GO:0060576)4.39406302
48cellular modified amino acid catabolic process (GO:0042219)4.38464001
49phosphatidylserine metabolic process (GO:0006658)4.37000853
50phosphatidylcholine acyl-chain remodeling (GO:0036151)4.30502895
51branched-chain amino acid metabolic process (GO:0009081)4.25518671
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.21593457
534-hydroxyproline metabolic process (GO:0019471)4.19012619
54signal peptide processing (GO:0006465)4.18947160
55maintenance of protein localization in organelle (GO:0072595)4.17104733
56water-soluble vitamin metabolic process (GO:0006767)4.16551136
57mucosal immune response (GO:0002385)4.13487223
58mitochondrial calcium ion transport (GO:0006851)4.01296053
59ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.01105821
60regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.96703860
61homocysteine metabolic process (GO:0050667)3.96215379
62ER overload response (GO:0006983)3.86983894
63response to unfolded protein (GO:0006986)3.86433869
64phosphatidic acid biosynthetic process (GO:0006654)3.84368315
65phosphatidic acid metabolic process (GO:0046473)3.84368315
66steroid catabolic process (GO:0006706)3.74853278
67glutamine metabolic process (GO:0006541)3.73165272
68response to topologically incorrect protein (GO:0035966)3.72173909
69organ or tissue specific immune response (GO:0002251)3.71196692
70L-alpha-amino acid transmembrane transport (GO:1902475)3.67210035
71leukotriene biosynthetic process (GO:0019370)3.66848934
72serine family amino acid biosynthetic process (GO:0009070)3.65587666
73negative regulation of epidermal cell differentiation (GO:0045605)3.63437787
74protein N-linked glycosylation via asparagine (GO:0018279)3.62687609
75peptidyl-asparagine modification (GO:0018196)3.60592322
76alditol phosphate metabolic process (GO:0052646)3.60181351
77regulation of acrosome reaction (GO:0060046)3.58679426
78positive regulation of heat generation (GO:0031652)3.56498831
79aspartate family amino acid catabolic process (GO:0009068)3.55605647
80sphingolipid catabolic process (GO:0030149)3.49552784
81GDP-mannose metabolic process (GO:0019673)3.47326551
82phosphatidylglycerol metabolic process (GO:0046471)3.40493793
83proline metabolic process (GO:0006560)3.37443929
84defense response to Gram-positive bacterium (GO:0050830)3.37023789
85regulation of fever generation (GO:0031620)3.35865700
86coenzyme catabolic process (GO:0009109)3.34344517
87protein N-linked glycosylation (GO:0006487)3.30074462
88creatine metabolic process (GO:0006600)3.29129693
89neutrophil mediated immunity (GO:0002446)3.25762484
90regulation of triglyceride catabolic process (GO:0010896)3.22840573
91cholesterol transport (GO:0030301)3.21996869
92sterol transport (GO:0015918)3.21996869
93antibacterial humoral response (GO:0019731)3.20300912
94vitamin metabolic process (GO:0006766)3.18532396
95L-phenylalanine catabolic process (GO:0006559)3.16799857
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16799857
97S-adenosylmethionine metabolic process (GO:0046500)3.16038829
98leukotriene metabolic process (GO:0006691)3.15522072
99cell redox homeostasis (GO:0045454)3.14130611
100vesicle coating (GO:0006901)3.13961550
101pancreas development (GO:0031016)3.10119774
102digestive system process (GO:0022600)3.08856665
103phototransduction, visible light (GO:0007603)3.06540711
104positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.06141308
105Golgi organization (GO:0007030)3.03272155
106antimicrobial humoral response (GO:0019730)2.97421870
107L-phenylalanine metabolic process (GO:0006558)2.95871514
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95871514
109acute-phase response (GO:0006953)2.94252928
110retinoid metabolic process (GO:0001523)2.93647588
111L-serine metabolic process (GO:0006563)2.91528333
112mitochondrion distribution (GO:0048311)2.89881942
113endothelial cell migration (GO:0043542)2.89576273
114regulation of epidermal cell differentiation (GO:0045604)2.85595156
115serine family amino acid metabolic process (GO:0009069)2.80916776
116glandular epithelial cell differentiation (GO:0002067)2.78154426
117diterpenoid metabolic process (GO:0016101)2.77847511
118negative regulation of epithelial cell differentiation (GO:0030857)2.76850954
119alcohol catabolic process (GO:0046164)2.74894328
120detection of visible light (GO:0009584)2.73503962
121regulation of cholesterol homeostasis (GO:2000188)2.72778002
122polarized epithelial cell differentiation (GO:0030859)2.71746496
123water-soluble vitamin biosynthetic process (GO:0042364)2.68857710
124UDP-N-acetylglucosamine metabolic process (GO:0006047)2.68259817
125arachidonic acid secretion (GO:0050482)2.67326640
126icosanoid secretion (GO:0032309)2.67326640
127regulation of heat generation (GO:0031650)2.66295682
128negative regulation of epidermis development (GO:0045683)2.65135436
129regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.64726207
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64245589
131cellular protein catabolic process (GO:0044257)2.62698688
132regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62007174
133primary alcohol catabolic process (GO:0034310)2.61861068
134regulation of digestive system process (GO:0044058)2.60674557
135regulation of oxidative stress-induced cell death (GO:1903201)2.59641211
136peptide catabolic process (GO:0043171)2.58924776
137progesterone metabolic process (GO:0042448)2.57101251
138multicellular organismal catabolic process (GO:0044243)2.56777151
139biotin metabolic process (GO:0006768)2.56682061
140nucleotide-sugar biosynthetic process (GO:0009226)2.54645782
141terpenoid metabolic process (GO:0006721)2.51673700
142phototransduction (GO:0007602)2.51655871
143glycoside metabolic process (GO:0016137)2.49177037
144icosanoid biosynthetic process (GO:0046456)2.46715045
145fatty acid derivative biosynthetic process (GO:1901570)2.46715045
146glucuronate metabolic process (GO:0019585)2.46674127
147uronic acid metabolic process (GO:0006063)2.46674127
148macroautophagy (GO:0016236)2.45245677
149cellular glucuronidation (GO:0052695)2.44463579
150lipid catabolic process (GO:0016042)2.44387267
151positive regulation of wound healing (GO:0090303)2.42033473
152detection of light stimulus (GO:0009583)2.37445212
153multicellular organismal metabolic process (GO:0044236)2.34688913
154quinone metabolic process (GO:1901661)2.31188082
155calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.28768696
156retinal metabolic process (GO:0042574)2.28524600
157long-chain fatty acid transport (GO:0015909)2.28057696
158isoprenoid metabolic process (GO:0006720)2.26910686
159cellular response to cadmium ion (GO:0071276)2.21173809
160acute inflammatory response (GO:0002526)2.19564201
161glycine transport (GO:0015816)2.18236820
162intestinal cholesterol absorption (GO:0030299)18.2485503
163exocrine pancreas development (GO:0031017)16.2043144
164digestion (GO:0007586)13.3567346
165protein retention in ER lumen (GO:0006621)12.0620252
166maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.4670543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.39010281
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.59287216
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.91783995
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.84626606
5GATA1_22025678_ChIP-Seq_K562_Human3.29777829
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98508373
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.85822619
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.73049270
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.69956217
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.69892103
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.60731843
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.53976978
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.47333344
14* GATA4_25053715_ChIP-Seq_YYC3_Human2.28399883
15HTT_18923047_ChIP-ChIP_STHdh_Human2.22050861
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10100120
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.01884054
18* GATA6_25053715_ChIP-Seq_YYC3_Human1.93572035
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86918547
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.84866483
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82133671
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79239833
23PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.78373489
24VDR_22108803_ChIP-Seq_LS180_Human1.71443090
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66975128
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64809258
27GBX2_23144817_ChIP-Seq_PC3_Human1.64537219
28* ETV1_20927104_ChIP-Seq_GIST48_Human1.62987145
29P300_19829295_ChIP-Seq_ESCs_Human1.62157168
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61453376
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58304367
32FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.58253103
33* PHF8_20622853_ChIP-Seq_HELA_Human1.57532983
34FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.55864881
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54126490
36* HNFA_21074721_ChIP-Seq_CACO-2_Human1.52553965
37CREB1_26743006_Chip-Seq_LNCaP_Human1.51260820
38* NFYA_21822215_ChIP-Seq_K562_Human1.51153376
39* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.47914021
40* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.46998764
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.46596717
42* RBPJ_21746931_ChIP-Seq_IB4_Human1.46230999
43* GATA6_21074721_ChIP-Seq_CACO-2_Human1.45808224
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44462174
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44462174
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44462174
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44392168
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.44012680
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42672620
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41523432
51CHD1_26751641_Chip-Seq_LNCaP_Human1.41254502
52* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.40861109
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35465273
54TAF15_26573619_Chip-Seq_HEK293_Human1.35383836
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34911880
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33653376
57* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33584541
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33421359
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32027726
60* NFYB_21822215_ChIP-Seq_K562_Human1.31645212
61CLOCK_20551151_ChIP-Seq_293T_Human1.30050758
62LXR_22292898_ChIP-Seq_THP-1_Human1.29671245
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29107742
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.28921662
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27711996
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25362531
67AR_20517297_ChIP-Seq_VCAP_Human1.25338748
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24635672
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23254297
70EGR1_19032775_ChIP-ChIP_M12_Human1.22506258
71SOX2_19829295_ChIP-Seq_ESCs_Human1.21686560
72NANOG_19829295_ChIP-Seq_ESCs_Human1.21686560
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.21539129
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21539129
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.20834582
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20721046
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20553034
78SOX2_20726797_ChIP-Seq_SW620_Human1.20409887
79P68_20966046_ChIP-Seq_HELA_Human1.19855705
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.19849998
81CDX2_22108803_ChIP-Seq_LS180_Human1.19778134
82CEBPB_22108803_ChIP-Seq_LS180_Human1.18423888
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.18282651
84FOXH1_21741376_ChIP-Seq_ESCs_Human1.17322836
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17038255
86CBP_20019798_ChIP-Seq_JUKART_Human1.17038255
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14608444
88ERG_20517297_ChIP-Seq_VCAP_Human1.14320912
89IGF1R_20145208_ChIP-Seq_DFB_Human1.13726154
90ATF3_27146783_Chip-Seq_COLON_Human1.13111657
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13055748
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12701524
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12487518
94TP63_22573176_ChIP-Seq_HFKS_Human1.11893309
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11648145
96ZNF274_21170338_ChIP-Seq_K562_Hela1.10446442
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10154591
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.10093413
99HOXB7_26014856_ChIP-Seq_BT474_Human1.09346260
100CBP_21632823_ChIP-Seq_H3396_Human1.09322231
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08365170
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08341823
103AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07036205
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06737571
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05823210
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.05751653
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05550460
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05142208
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.04526094
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04223947
111* TBL1_22424771_ChIP-Seq_293T_Human1.02797910
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02461729
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02265900
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02203096
115* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02098181
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.01826985
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01178142
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99607689
119* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99522617
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98948634
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98457621
122RACK7_27058665_Chip-Seq_MCF-7_Human0.96135639
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95874590
124ER_23166858_ChIP-Seq_MCF-7_Human0.95649453
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95374812
126ERA_21632823_ChIP-Seq_H3396_Human0.95166659
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94875916
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.94748899
129OCT4_20526341_ChIP-Seq_ESCs_Human0.94399972
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94381979
131TAF2_19829295_ChIP-Seq_ESCs_Human0.94203869
132ETS1_21867929_ChIP-Seq_TH2_Mouse0.92941296
133* ESET_19884257_ChIP-Seq_ESCs_Mouse0.92230602
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91955696
135RUNX2_22187159_ChIP-Seq_PCA_Human0.90597697
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89845595
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.89638307
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.89638307
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89528989
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89072635
141SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88923174
142IRF1_19129219_ChIP-ChIP_H3396_Human0.88387300
143SMAD4_21799915_ChIP-Seq_A2780_Human0.88142991
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87820086
145BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87678920
146KDM2B_26808549_Chip-Seq_K562_Human0.86993366
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86056099
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85770177
149BCAT_22108803_ChIP-Seq_LS180_Human0.84616385
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84242067
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83473456
152STAT3_23295773_ChIP-Seq_U87_Human0.83395715
153SMAD_19615063_ChIP-ChIP_OVARY_Human0.83301828
154* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83014966
155BCOR_27268052_Chip-Seq_Bcells_Human0.82992615
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82757740
157ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82652532
158CJUN_26792858_Chip-Seq_BT549_Human0.82541149
159NFE2_27457419_Chip-Seq_LIVER_Mouse0.81234875
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81234520
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80951800
162SA1_27219007_Chip-Seq_Bcells_Human0.80190854
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80037584
164GATA1_19941826_ChIP-Seq_K562_Human0.79951307
165P53_21459846_ChIP-Seq_SAOS-2_Human0.79827878
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79312077
167TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78508338
168CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78508260
169JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.77713584
170FOXP1_21924763_ChIP-Seq_HESCs_Human0.77471873
171OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77449996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption8.81606558
2MP0005083_abnormal_biliary_tract8.78827747
3MP0005220_abnormal_exocrine_pancreas6.44125414
4MP0005365_abnormal_bile_salt6.30940140
5MP0003868_abnormal_feces_composition5.07207124
6MP0005084_abnormal_gallbladder_morpholo4.79915290
7MP0002693_abnormal_pancreas_physiology3.27350327
8MP0005085_abnormal_gallbladder_physiolo3.18510117
9MP0002138_abnormal_hepatobiliary_system2.83027060
10MP0003959_abnormal_lean_body2.69243112
11MP0001944_abnormal_pancreas_morphology2.40509571
12MP0002139_abnormal_hepatobiliary_system2.29843475
13MP0001664_abnormal_digestion2.26807921
14MP0004264_abnormal_extraembryonic_tissu1.98833836
15MP0003252_abnormal_bile_duct1.86845599
16MP0003705_abnormal_hypodermis_morpholog1.86370803
17MP0002928_abnormal_bile_duct1.72137826
18MP0005448_abnormal_energy_balance1.69704368
19MP0010234_abnormal_vibrissa_follicle1.65856298
20MP0003283_abnormal_digestive_organ1.45026427
21MP0004233_abnormal_muscle_weight1.36027034
22MP0003638_abnormal_response/metabolism_1.35210785
23MP0002078_abnormal_glucose_homeostasis1.33673108
24MP0002118_abnormal_lipid_homeostasis1.31457032
25MP0003300_gastrointestinal_ulcer1.21244932
26MP0005165_increased_susceptibility_to1.20650501
27MP0009780_abnormal_chondrocyte_physiolo1.16981442
28MP0000003_abnormal_adipose_tissue1.16018356
29MP0008004_abnormal_stomach_pH1.12615274
30MP0002163_abnormal_gland_morphology1.12098430
31MP0005332_abnormal_amino_acid1.06070238
32MP0003045_fibrosis1.05075690
33MP0002277_abnormal_respiratory_mucosa1.03703740
34MP0001501_abnormal_sleep_pattern0.97685263
35MP0008961_abnormal_basal_metabolism0.96317012
36MP0000470_abnormal_stomach_morphology0.95437928
37MP0002877_abnormal_melanocyte_morpholog0.94892827
38MP0006054_spinal_hemorrhage0.93879182
39MP0009643_abnormal_urine_homeostasis0.91845143
40MP0003953_abnormal_hormone_level0.91179311
41MP0001502_abnormal_circadian_rhythm0.90334372
42MP0005535_abnormal_body_temperature0.87717177
43MP0008872_abnormal_physiological_respon0.86810088
44MP0002837_dystrophic_cardiac_calcinosis0.83961558
45MP0008875_abnormal_xenobiotic_pharmacok0.83635530
46MP0005408_hypopigmentation0.83615528
47MP0004043_abnormal_pH_regulation0.80492022
48MP0000613_abnormal_salivary_gland0.80356923
49MP0005451_abnormal_body_composition0.78848193
50MP0002132_abnormal_respiratory_system0.75458338
51MP0003950_abnormal_plasma_membrane0.73722109
52MP0008995_early_reproductive_senescence0.73098566
53MP0005058_abnormal_lysosome_morphology0.72425277
54MP0005379_endocrine/exocrine_gland_phen0.72193560
55MP0003183_abnormal_peptide_metabolism0.70788299
56MP0003011_delayed_dark_adaptation0.70083090
57MP0003195_calcinosis0.69311199
58MP0002909_abnormal_adrenal_gland0.68370498
59MP0000013_abnormal_adipose_tissue0.67352931
60MP0010678_abnormal_skin_adnexa0.67160033
61MP0009384_cardiac_valve_regurgitation0.64555177
62MP0005670_abnormal_white_adipose0.64378834
63MP0005452_abnormal_adipose_tissue0.64195296
64MP0002970_abnormal_white_adipose0.62416685
65MP0002896_abnormal_bone_mineralization0.61348671
66MP0001873_stomach_inflammation0.58894689
67MP0008438_abnormal_cutaneous_collagen0.58245703
68MP0000490_abnormal_crypts_of0.58215966
69MP0004147_increased_porphyrin_level0.58046572
70MP0008789_abnormal_olfactory_epithelium0.57584966
71MP0000598_abnormal_liver_morphology0.56658852
72MP0005375_adipose_tissue_phenotype0.56437001
73MP0010329_abnormal_lipoprotein_level0.55990128
74MP0005551_abnormal_eye_electrophysiolog0.55551103
75MP0000609_abnormal_liver_physiology0.52814382
76MP0003646_muscle_fatigue0.52570848
77MP0010386_abnormal_urinary_bladder0.52298805
78MP0001731_abnormal_postnatal_growth0.50713176
79MP0005410_abnormal_fertilization0.48916850
80MP0001663_abnormal_digestive_system0.47457260
81MP0005646_abnormal_pituitary_gland0.47307785
82MP0003806_abnormal_nucleotide_metabolis0.47139091
83MP0000383_abnormal_hair_follicle0.46974460
84MP0002876_abnormal_thyroid_physiology0.46771747
85MP0004185_abnormal_adipocyte_glucose0.46334039
86MP0001485_abnormal_pinna_reflex0.45936457
87MP0005381_digestive/alimentary_phenotyp0.44382775
88MP0005187_abnormal_penis_morphology0.44311671
89MP0003656_abnormal_erythrocyte_physiolo0.43644999
90MP0002234_abnormal_pharynx_morphology0.42928188
91MP0005499_abnormal_olfactory_system0.42560153
92MP0005394_taste/olfaction_phenotype0.42560153
93MP0009765_abnormal_xenobiotic_induced0.42510517
94MP0004019_abnormal_vitamin_homeostasis0.41788888
95MP0003172_abnormal_lysosome_physiology0.41595679
96MP0006036_abnormal_mitochondrial_physio0.41583358
97MP0008877_abnormal_DNA_methylation0.40804859
98MP0001764_abnormal_homeostasis0.40489141
99MP0009703_decreased_birth_body0.39380703
100MP0005334_abnormal_fat_pad0.39293639
101MP0002098_abnormal_vibrissa_morphology0.38915061
102MP0003795_abnormal_bone_structure0.38874816
103MP0003943_abnormal_hepatobiliary_system0.38656691
104MP0001845_abnormal_inflammatory_respons0.37904088
105MP0001765_abnormal_ion_homeostasis0.36976176
106MP0002089_abnormal_postnatal_growth/wei0.36539047
107MP0002069_abnormal_eating/drinking_beha0.35268810
108MP0009642_abnormal_blood_homeostasis0.35188729
109MP0001348_abnormal_lacrimal_gland0.34883807
110MP0005253_abnormal_eye_physiology0.34374426
111MP0003786_premature_aging0.34071681
112MP0003186_abnormal_redox_activity0.33325916
113MP0002168_other_aberrant_phenotype0.33005566
114MP0005319_abnormal_enzyme/_coenzyme0.32515944
115MP0005645_abnormal_hypothalamus_physiol0.32431600
116MP0000371_diluted_coat_color0.31918427
117MP0000538_abnormal_urinary_bladder0.31854139
118MP0000678_abnormal_parathyroid_gland0.31743498
119MP0009764_decreased_sensitivity_to0.31204054
120MP0003329_amyloid_beta_deposits0.30834445
121MP0009672_abnormal_birth_weight0.30817910
122MP0001756_abnormal_urination0.30548559
123MP0002060_abnormal_skin_morphology0.30257957
124MP0006276_abnormal_autonomic_nervous0.29702969
125MP0005360_urolithiasis0.29634589
126MP0003718_maternal_effect0.28953285
127MP0000367_abnormal_coat/_hair0.28775862
128MP0002796_impaired_skin_barrier0.28105012
129MP0002638_abnormal_pupillary_reflex0.27798302
130MP0005636_abnormal_mineral_homeostasis0.27718144
131MP0000750_abnormal_muscle_regeneration0.27457685
132MP0005395_other_phenotype0.27453505
133MP0000955_abnormal_spinal_cord0.27297195
134MP0003878_abnormal_ear_physiology0.27013437
135MP0005377_hearing/vestibular/ear_phenot0.27013437
136MP0008770_decreased_survivor_rate0.27013273
137MP0000631_abnormal_neuroendocrine_gland0.26964978
138MP0009840_abnormal_foam_cell0.26476384
139MP0003866_abnormal_defecation0.26375996
140MP0000462_abnormal_digestive_system0.25660764
141MP0002102_abnormal_ear_morphology0.25268475
142MP0004484_altered_response_of0.22938194
143MP0006072_abnormal_retinal_apoptosis0.22366567
144MP0004145_abnormal_muscle_electrophysio0.21447153
145MP0002136_abnormal_kidney_physiology0.19911216

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.83525196
2Fat malabsorption (HP:0002630)6.76018744
3Gout (HP:0001997)6.40104205
4Exocrine pancreatic insufficiency (HP:0001738)5.41103913
5Abnormal pancreas size (HP:0012094)5.07308947
6Decreased subcutaneous fat (HP:0001002)5.06529503
7Short chin (HP:0000331)4.83149439
8Abnormality of the intrinsic pathway (HP:0010989)4.58484958
9Type I diabetes mellitus (HP:0100651)4.56893532
10Abnormality of subcutaneous fat tissue (HP:0001001)4.53849711
11Abnormality of endocrine pancreas physiology (HP:0012093)4.44554919
12Abnormality of the pancreatic islet cells (HP:0006476)4.44554919
13Ketoacidosis (HP:0001993)4.31782730
14Hyperinsulinemic hypoglycemia (HP:0000825)4.30899104
15Hypoglycemic seizures (HP:0002173)4.16093489
16Hypoglycemic coma (HP:0001325)4.12371975
17Maternal diabetes (HP:0009800)4.00252362
18Ketosis (HP:0001946)3.80182148
19Hypoplasia of the pons (HP:0012110)3.74195906
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68178744
21Abnormality of the pleura (HP:0002103)3.60264646
22Late onset (HP:0003584)3.59842186
23Pancreatitis (HP:0001733)3.52232090
24Abnormality of the pons (HP:0007361)3.47346287
25Tubulointerstitial fibrosis (HP:0005576)3.44144142
26Premature skin wrinkling (HP:0100678)3.18819460
27Joint stiffness (HP:0001387)3.18263815
28Hyperglycemia (HP:0003074)3.15626098
29Tetraparesis (HP:0002273)3.15414570
30Hypoproteinemia (HP:0003075)3.14191841
31Symptomatic seizures (HP:0011145)3.11021290
32Tubulointerstitial nephritis (HP:0001970)3.02367238
33Abnormality of the common coagulation pathway (HP:0010990)2.96891230
34Cortical dysplasia (HP:0002539)2.96770321
35Increased purine levels (HP:0004368)2.84185088
36Hyperuricemia (HP:0002149)2.84185088
37Large for gestational age (HP:0001520)2.82744753
38Hydroxyprolinuria (HP:0003080)2.81296118
39Abnormality of proline metabolism (HP:0010907)2.81296118
40Anal atresia (HP:0002023)2.80652878
41Type I transferrin isoform profile (HP:0003642)2.74517619
42Carpal bone hypoplasia (HP:0001498)2.69794881
43Dysostosis multiplex (HP:0000943)2.63363052
44Pancreatic islet-cell hyperplasia (HP:0004510)2.63096906
45Congenital glaucoma (HP:0001087)2.60664262
46Insulin-resistant diabetes mellitus (HP:0000831)2.59648361
47Unilateral renal agenesis (HP:0000122)2.51272734
48Ventricular fibrillation (HP:0001663)2.46869777
49Long foot (HP:0001833)2.46364823
50Reduced antithrombin III activity (HP:0001976)2.46118000
51Conjugated hyperbilirubinemia (HP:0002908)2.40448996
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.40420954
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37791448
54Progressive muscle weakness (HP:0003323)2.36625362
55Abnormal protein glycosylation (HP:0012346)2.36619547
56Abnormal glycosylation (HP:0012345)2.36619547
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36619547
58Abnormal protein N-linked glycosylation (HP:0012347)2.36619547
59Abnormal tarsal ossification (HP:0008369)2.36287092
60Hyperglycinemia (HP:0002154)2.34735603
61Esophageal varix (HP:0002040)2.34019556
62Pancreatic cysts (HP:0001737)2.32760481
63Cerebellar dysplasia (HP:0007033)2.31923828
64Prenatal maternal abnormality (HP:0002686)2.24270926
65Vascular calcification (HP:0004934)2.22492376
66Pectus carinatum (HP:0000768)2.21460837
67Facial shape deformation (HP:0011334)2.21184564
68Potter facies (HP:0002009)2.21184564
69Hypoplasia of the odontoid process (HP:0003311)2.20292759
70Acute hepatic failure (HP:0006554)2.19961311
71Abnormality of purine metabolism (HP:0004352)2.17974911
72Urinary glycosaminoglycan excretion (HP:0003541)2.17033767
73Mucopolysacchariduria (HP:0008155)2.17033767
74Sex reversal (HP:0012245)2.16633806
75Abnormal sex determination (HP:0012244)2.16633806
76Fatigue (HP:0012378)2.16539358
77Abnormality of the renal cortex (HP:0011035)2.15982510
78Cortical visual impairment (HP:0100704)2.15436060
79Hypsarrhythmia (HP:0002521)2.15347968
80Optic nerve hypoplasia (HP:0000609)2.11425159
81Insulin resistance (HP:0000855)2.11015173
82Medial flaring of the eyebrow (HP:0010747)2.10214971
83Ankyloglossia (HP:0010296)2.09887899
84Severe short stature (HP:0003510)2.08083585
85Limb hypertonia (HP:0002509)2.06921517
86EEG with generalized epileptiform discharges (HP:0011198)2.06143098
87Ileus (HP:0002595)2.05285549
88Abnormality of the renal medulla (HP:0100957)2.04973584
89Hyperglycinuria (HP:0003108)2.04336410
90Abnormality of methionine metabolism (HP:0010901)2.03829632
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01442391
92Small epiphyses (HP:0010585)2.00935576
93Abnormality of glutamine family amino acid metabolism (HP:0010902)2.00131196
94Type II lissencephaly (HP:0007260)1.99703339
95Prolonged QT interval (HP:0001657)1.98313660
96Tubulointerstitial abnormality (HP:0001969)1.96847630
97Epileptiform EEG discharges (HP:0011182)1.95576215
98Methylmalonic acidemia (HP:0002912)1.95067845
99Hypoplasia of the uterus (HP:0000013)1.94000668
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92175739
101Abnormal biliary tract morphology (HP:0012440)1.90357454
102Abnormality of polysaccharide metabolism (HP:0011012)1.90291134
103Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90291134
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90291134
105Vacuolated lymphocytes (HP:0001922)1.89511107
106Abnormality of glycine metabolism (HP:0010895)1.88681790
107Abnormality of serine family amino acid metabolism (HP:0010894)1.88681790
108Neonatal death (HP:0003811)1.87997095
109Right ventricular cardiomyopathy (HP:0011663)1.86327018
110Congenital stationary night blindness (HP:0007642)1.85510905
111Myocardial infarction (HP:0001658)1.84919471
112Male infertility (HP:0003251)1.84641328
113Chronic hepatic failure (HP:0100626)1.83329324
114Barrel-shaped chest (HP:0001552)1.82469589
115Cardiovascular calcification (HP:0011915)1.82277969
116Glycosuria (HP:0003076)1.81888235
117Abnormality of urine glucose concentration (HP:0011016)1.81888235
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80671002
119Abnormal foot bone ossification (HP:0010675)1.79839495
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78364712
121Intrahepatic cholestasis (HP:0001406)1.77676688
122Glucose intolerance (HP:0000833)1.77556265
123Aplasia/hypoplasia of the uterus (HP:0008684)1.77289329
124Congenital primary aphakia (HP:0007707)1.73681987
125Hypotension (HP:0002615)1.73127970
126Abnormality of the odontoid process (HP:0003310)1.72344855
127Tubular atrophy (HP:0000092)1.72229574
128Renal salt wasting (HP:0000127)1.71596186
129Lissencephaly (HP:0001339)1.71446333
130Nephrogenic diabetes insipidus (HP:0009806)1.70201538
131Abnormality of the nasal septum (HP:0000419)1.68136487
132Popliteal pterygium (HP:0009756)1.68035159
133Gait imbalance (HP:0002141)1.67415212
134Enlarged kidneys (HP:0000105)1.62832173
135Rectal prolapse (HP:0002035)1.61470119
136Methylmalonic aciduria (HP:0012120)1.61131625
137Severe muscular hypotonia (HP:0006829)1.59301772
138Gaze-evoked nystagmus (HP:0000640)1.57793137
139Abnormality of vitamin B metabolism (HP:0004340)1.57375021
140Nephronophthisis (HP:0000090)1.55714452
141Portal hypertension (HP:0001409)1.55135127
142Lower limb hyperreflexia (HP:0002395)1.53076765
143Attenuation of retinal blood vessels (HP:0007843)1.52563873
144Cystic liver disease (HP:0006706)1.52357808
145Molar tooth sign on MRI (HP:0002419)1.51142974
146Abnormality of midbrain morphology (HP:0002418)1.51142974
147Azoospermia (HP:0000027)1.48047701
148Paraparesis (HP:0002385)1.47977242
149Abnormality of vitamin metabolism (HP:0100508)1.46964126
150Genetic anticipation (HP:0003743)1.46843084
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.46224279
152Abnormality of alanine metabolism (HP:0010916)1.46224279
153Hyperalaninemia (HP:0003348)1.46224279
154Congenital malformation of the right heart (HP:0011723)1.44922959
155Double outlet right ventricle (HP:0001719)1.44922959
156Abnormality of the vitamin B12 metabolism (HP:0004341)1.44467877
157Congenital, generalized hypertrichosis (HP:0004540)1.41291560
158Type II diabetes mellitus (HP:0005978)1.39383251
159Poor coordination (HP:0002370)1.37559667
160Abdominal pain (HP:0002027)1.37047389
161Abnormality of the hepatic vasculature (HP:0006707)1.35952949
1623-Methylglutaconic aciduria (HP:0003535)1.35673934
163Stenosis of the external auditory canal (HP:0000402)1.34729733
164Hepatocellular necrosis (HP:0001404)1.34278362
165True hermaphroditism (HP:0010459)1.34097291
166Congenital hepatic fibrosis (HP:0002612)1.33587374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.18684077
2LMTK25.60859542
3ERN15.13710756
4INSRR4.16007723
5EIF2AK34.12325455
6MAP2K23.61557178
7EPHA23.51132042
8TRIB33.39331778
9GRK13.32902673
10TAOK32.98618835
11FRK2.82310114
12EIF2AK12.81319336
13PKN22.80882609
14MAPK152.36214651
15MAP4K21.98047337
16SCYL21.95265132
17OXSR11.95263026
18BMPR1B1.91968808
19IRAK31.83996539
20MST41.76305643
21ZAP701.76221275
22MAPKAPK31.75776861
23MAP3K21.52329836
24PTK61.50919078
25WNK41.47313387
26FLT31.46423631
27MAP2K11.45302484
28CCNB11.45020302
29BCR1.40790839
30PASK1.35708128
31NUAK11.33207934
32ADRBK21.32675814
33PIM21.30831899
34MAP3K121.29564981
35PAK21.28897819
36TRIM281.21056874
37PRKD31.15237226
38PDGFRB1.13188801
39STK161.11864396
40ACVR1B1.09029191
41NME11.08466932
42SIK11.07432716
43HIPK21.04961972
44MUSK1.03572103
45DYRK1A1.01720783
46CAMKK20.98662891
47LATS10.98090040
48CSNK1G10.97271121
49MAP3K10.95869424
50MAP3K40.94319970
51CAMKK10.93839105
52DYRK1B0.93315082
53RPS6KB20.91660108
54CSNK1G30.91502993
55PIK3CG0.91453195
56NME20.88541053
57PRKCH0.88365589
58NLK0.87951140
59PDGFRA0.85563825
60EEF2K0.82272644
61CSNK1A1L0.81134244
62RET0.80082008
63PRKG20.75300674
64RIPK10.75293786
65STK38L0.75103593
66NTRK10.75026934
67IRAK20.73280578
68CDK190.73133129
69NEK20.73080855
70MTOR0.73016092
71ERBB30.72907025
72FGFR40.70619486
73PAK30.69654167
74EPHA30.67332219
75VRK20.66252837
76PIK3CA0.65288987
77MAPKAPK50.64595580
78WNK30.63967559
79ERBB40.63051957
80DAPK20.62630190
81FER0.61414263
82PRKCI0.61176363
83PTK20.61158415
84EPHB10.59559722
85MAP3K50.56646403
86IRAK10.53048040
87VRK10.52732455
88DAPK10.51685375
89MET0.50778650
90PDPK10.49525986
91EIF2AK20.49438522
92JAK20.49287840
93MAP2K60.48063973
94MELK0.47648457
95KSR20.47621443
96MST1R0.47365972
97RPS6KB10.46229751
98CASK0.43853056
99MAPK130.43654826
100PRKAA20.43230862
101IRAK40.43092718
102CHUK0.42846134
103TAF10.41566470
104PRKCZ0.41561080
105CDK80.41364109
106PRKD10.40257905
107PRKD20.39938306
108PDK20.39867934
109TIE10.39767597
110TRPM70.39726230
111LRRK20.39392964
112NTRK30.39141186
113PDK10.36135932
114PRKCQ0.35971547
115CAMK40.32188422
116STK390.31795620
117UHMK10.31588067
118FGFR30.30941378
119CDC42BPA0.30510148
120TXK0.30412095
121NEK60.30292262
122PRKCA0.29460834
123STK30.29459931
124MAPK30.28528696
125ADRBK10.28182953
126MAP3K30.27480456
127SGK20.27476714
128STK380.26874918
129IGF1R0.26097341
130CAMK1D0.24844230
131GSK3A0.24291367
132ROCK10.23282832
133MAP3K70.22965120
134TNIK0.22341883
135PRKACB0.21631721
136PRKAA10.21517054
137TGFBR20.21036657
138PRKCG0.20410951
139JAK10.19453191
140RPS6KA10.19449443
141TSSK60.19380904
142CSNK1D0.18603284
143MAPK10.18537279
144ILK0.18421748
145TEC0.18215474
146ABL10.17507304
147MAPK120.17145495
148PINK10.16591022
149WNK10.13698076
150EGFR0.13433858
151MAP3K90.13428058
152CSNK1A10.13388870
153AKT10.12374351
154RPS6KA30.11546385
155TBK10.11495083
156CSNK1E0.11400339
157PRKACA0.11370364
158CSNK1G20.10928179
159PRKACG0.10793591
160BRSK20.10415463
161PRKCE0.09945738

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049727.97149530
2Fat digestion and absorption_Homo sapiens_hsa049756.01892963
3* Protein digestion and absorption_Homo sapiens_hsa049745.06705799
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.93948858
5Protein export_Homo sapiens_hsa030603.63471838
6Glycerolipid metabolism_Homo sapiens_hsa005612.88566266
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.66225827
8Folate biosynthesis_Homo sapiens_hsa007902.63214946
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.11992749
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02613453
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85793745
12Vitamin digestion and absorption_Homo sapiens_hsa049771.82309580
13Steroid biosynthesis_Homo sapiens_hsa001001.80819692
14Renin-angiotensin system_Homo sapiens_hsa046141.51694982
15Propanoate metabolism_Homo sapiens_hsa006401.37682302
16Insulin secretion_Homo sapiens_hsa049111.27715200
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25498641
18N-Glycan biosynthesis_Homo sapiens_hsa005101.12271057
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12109457
20Linoleic acid metabolism_Homo sapiens_hsa005911.07964456
21Sulfur metabolism_Homo sapiens_hsa009201.00448256
22Starch and sucrose metabolism_Homo sapiens_hsa005001.00033714
23Selenocompound metabolism_Homo sapiens_hsa004500.98287968
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90363435
25Arginine and proline metabolism_Homo sapiens_hsa003300.89218357
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88759708
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84803739
28Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83514169
29Other glycan degradation_Homo sapiens_hsa005110.83107161
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81848656
31Vibrio cholerae infection_Homo sapiens_hsa051100.79506714
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77057788
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76860590
34Circadian rhythm_Homo sapiens_hsa047100.76097864
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71158075
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69913241
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69419932
38Phototransduction_Homo sapiens_hsa047440.68712790
39Biosynthesis of amino acids_Homo sapiens_hsa012300.67133547
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66816827
41Influenza A_Homo sapiens_hsa051640.66810298
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.64486480
43Notch signaling pathway_Homo sapiens_hsa043300.61525762
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60640004
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55683036
46Chemical carcinogenesis_Homo sapiens_hsa052040.52732382
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52110416
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.51741541
49One carbon pool by folate_Homo sapiens_hsa006700.51654503
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50758603
51Type I diabetes mellitus_Homo sapiens_hsa049400.49894250
52Type II diabetes mellitus_Homo sapiens_hsa049300.49029866
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48151161
54Lysosome_Homo sapiens_hsa041420.47699296
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46848063
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46075591
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42674697
58Tryptophan metabolism_Homo sapiens_hsa003800.42077511
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39664538
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.38568773
61Fatty acid degradation_Homo sapiens_hsa000710.37020394
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36755204
63Vitamin B6 metabolism_Homo sapiens_hsa007500.36580058
64beta-Alanine metabolism_Homo sapiens_hsa004100.36274931
65Legionellosis_Homo sapiens_hsa051340.34510211
66Retinol metabolism_Homo sapiens_hsa008300.33568063
67Insulin resistance_Homo sapiens_hsa049310.33381554
68Histidine metabolism_Homo sapiens_hsa003400.32556562
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32092187
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31996890
71Regulation of autophagy_Homo sapiens_hsa041400.30257205
72Cocaine addiction_Homo sapiens_hsa050300.29942229
73Endometrial cancer_Homo sapiens_hsa052130.29478656
74Proteasome_Homo sapiens_hsa030500.28646568
75Pyruvate metabolism_Homo sapiens_hsa006200.27899029
76Nitrogen metabolism_Homo sapiens_hsa009100.26157196
77mTOR signaling pathway_Homo sapiens_hsa041500.25447089
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24713674
79Arachidonic acid metabolism_Homo sapiens_hsa005900.24495896
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.23551406
81Fructose and mannose metabolism_Homo sapiens_hsa000510.23390254
82Ether lipid metabolism_Homo sapiens_hsa005650.23355740
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22949855
84Peroxisome_Homo sapiens_hsa041460.22626420
85Thyroid hormone synthesis_Homo sapiens_hsa049180.21551334
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21174023
87Arginine biosynthesis_Homo sapiens_hsa002200.20850039
88VEGF signaling pathway_Homo sapiens_hsa043700.20226213
89Metabolic pathways_Homo sapiens_hsa011000.19485383
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19210868
91Prostate cancer_Homo sapiens_hsa052150.18883546
92Mineral absorption_Homo sapiens_hsa049780.18880239
93ABC transporters_Homo sapiens_hsa020100.18062833
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16842169
95Estrogen signaling pathway_Homo sapiens_hsa049150.16677880
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16458978
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.14738280
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14266471
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13301601
100Bladder cancer_Homo sapiens_hsa052190.12415604
101Insulin signaling pathway_Homo sapiens_hsa049100.11670705
102Caffeine metabolism_Homo sapiens_hsa002320.11408967
103Calcium signaling pathway_Homo sapiens_hsa040200.11127011
104Bile secretion_Homo sapiens_hsa049760.10800023
105Glutathione metabolism_Homo sapiens_hsa004800.10314813
106Sphingolipid metabolism_Homo sapiens_hsa006000.10247996
107Ovarian steroidogenesis_Homo sapiens_hsa049130.10224897
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.09248863
109Glucagon signaling pathway_Homo sapiens_hsa049220.09175864
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08974346
111Galactose metabolism_Homo sapiens_hsa000520.08190897
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07660508
113Carbon metabolism_Homo sapiens_hsa012000.07316920
114Cholinergic synapse_Homo sapiens_hsa047250.07118815
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06923172
116AMPK signaling pathway_Homo sapiens_hsa041520.06911405
117Prion diseases_Homo sapiens_hsa050200.06294708
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.05976044
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.05892019
120Basal transcription factors_Homo sapiens_hsa030220.04847034
121Toxoplasmosis_Homo sapiens_hsa051450.04843056
122Gastric acid secretion_Homo sapiens_hsa049710.04161499
123Hepatitis C_Homo sapiens_hsa051600.03810609
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03576522
125Fatty acid metabolism_Homo sapiens_hsa012120.03238699
126Butanoate metabolism_Homo sapiens_hsa006500.02873937
127Alzheimers disease_Homo sapiens_hsa050100.02698756
128Lysine degradation_Homo sapiens_hsa003100.02386753
129Tight junction_Homo sapiens_hsa045300.01956162
130Oxidative phosphorylation_Homo sapiens_hsa001900.01466950
131RNA polymerase_Homo sapiens_hsa030200.00825585
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00178965
133Rheumatoid arthritis_Homo sapiens_hsa05323-0.0838157
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130-0.0790948
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0768080
136Ras signaling pathway_Homo sapiens_hsa04014-0.0766222
137Complement and coagulation cascades_Homo sapiens_hsa04610-0.0607666
138RNA degradation_Homo sapiens_hsa03018-0.0585294
139Olfactory transduction_Homo sapiens_hsa04740-0.0579213
140Fatty acid elongation_Homo sapiens_hsa00062-0.0565771
141Non-homologous end-joining_Homo sapiens_hsa03450-0.0524353
142Taste transduction_Homo sapiens_hsa04742-0.0435507

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