CELF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.77923989
2histone H3-K36 demethylation (GO:0070544)4.53813175
3layer formation in cerebral cortex (GO:0021819)4.33435111
4histone-serine phosphorylation (GO:0035404)4.29514338
5pore complex assembly (GO:0046931)4.28420203
6regulation of NFAT protein import into nucleus (GO:0051532)4.20617482
7mitochondrion distribution (GO:0048311)3.96709507
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.88422939
9generation of neurons (GO:0048699)3.81180016
10locomotory exploration behavior (GO:0035641)3.80116544
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79412509
12positive regulation of cell cycle G2/M phase transition (GO:1902751)3.74331705
13positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.74331705
14positive regulation of dendritic spine morphogenesis (GO:0061003)3.74181211
15regulation of histone H3-K9 methylation (GO:0051570)3.73181675
16positive regulation of gene expression, epigenetic (GO:0045815)3.70836527
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.69321097
18positive regulation of synapse maturation (GO:0090129)3.64291909
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60678079
20vocalization behavior (GO:0071625)3.59544990
21mitotic chromosome condensation (GO:0007076)3.58152782
22negative regulation of activin receptor signaling pathway (GO:0032926)3.57311284
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.56275668
24positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.54496059
25monoubiquitinated protein deubiquitination (GO:0035520)3.52500124
26regulation of nucleobase-containing compound transport (GO:0032239)3.49730255
27DNA duplex unwinding (GO:0032508)3.49611655
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.47262107
29mitochondrion transport along microtubule (GO:0047497)3.47262107
30regulation of glutamate receptor signaling pathway (GO:1900449)3.47083037
31negative regulation of DNA repair (GO:0045738)3.42631682
32regulation of dendritic spine morphogenesis (GO:0061001)3.39899097
33histone lysine demethylation (GO:0070076)3.38224787
34peptidyl-lysine dimethylation (GO:0018027)3.38161238
35establishment of nucleus localization (GO:0040023)3.34150910
36DNA geometric change (GO:0032392)3.33147996
37histone phosphorylation (GO:0016572)3.32025371
38dendritic spine morphogenesis (GO:0060997)3.31843339
39regulation of spindle organization (GO:0090224)3.30777326
40establishment of mitochondrion localization (GO:0051654)3.30289186
41mRNA stabilization (GO:0048255)3.22546301
42RNA stabilization (GO:0043489)3.22546301
43histone demethylation (GO:0016577)3.20265730
44negative regulation of histone methylation (GO:0031061)3.20010148
45synaptic vesicle maturation (GO:0016188)3.19526271
46histone H3-K9 demethylation (GO:0033169)3.18049178
47intracellular estrogen receptor signaling pathway (GO:0030520)3.16164544
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.13649813
49mitochondrion localization (GO:0051646)3.13470584
50glutamate receptor signaling pathway (GO:0007215)3.13081536
51regulation of histone H3-K27 methylation (GO:0061085)3.12631892
52cytoskeletal anchoring at plasma membrane (GO:0007016)3.09670633
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09432583
54nucleosome disassembly (GO:0006337)3.09315137
55protein-DNA complex disassembly (GO:0032986)3.09315137
56histone H4 acetylation (GO:0043967)3.07823919
57cerebellar Purkinje cell differentiation (GO:0021702)3.05354045
58positive regulation of DNA-dependent DNA replication (GO:2000105)3.03200324
59stress granule assembly (GO:0034063)3.01573995
60histone H3-K4 trimethylation (GO:0080182)2.99811254
61DNA synthesis involved in DNA repair (GO:0000731)2.98620714
62nuclear pore organization (GO:0006999)2.97534705
63axonal fasciculation (GO:0007413)2.97131052
64glial cell proliferation (GO:0014009)2.96533965
65regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96321639
66regulation of histone methylation (GO:0031060)2.94532016
67regulation of transforming growth factor beta2 production (GO:0032909)2.94240364
68synaptic vesicle docking involved in exocytosis (GO:0016081)2.94031955
69cell communication by electrical coupling (GO:0010644)2.93627113
70mitotic sister chromatid cohesion (GO:0007064)2.92893829
71nuclear pore complex assembly (GO:0051292)2.92643936
72neuromuscular process controlling balance (GO:0050885)2.92088734
73neuron recognition (GO:0008038)2.91621197
74regulation of sister chromatid cohesion (GO:0007063)2.91153747
75citrulline metabolic process (GO:0000052)2.90626499
76positive regulation of cell cycle checkpoint (GO:1901978)2.90164497
77histone H3-K4 methylation (GO:0051568)2.89047160
78cell migration in hindbrain (GO:0021535)2.88716897
79RNA localization (GO:0006403)2.86927179
80regulation of gene silencing by RNA (GO:0060966)2.85606206
81regulation of posttranscriptional gene silencing (GO:0060147)2.85606206
82regulation of gene silencing by miRNA (GO:0060964)2.85606206
83regulation of synapse structural plasticity (GO:0051823)2.84634564
84DNA topological change (GO:0006265)2.84603928
85dosage compensation (GO:0007549)2.83684007
86regulation of neuronal synaptic plasticity (GO:0048168)2.83200626
87protein dealkylation (GO:0008214)2.82110176
88protein demethylation (GO:0006482)2.82110176
89exploration behavior (GO:0035640)2.78769285
90synaptic transmission, glutamatergic (GO:0035249)2.78142106
91histone deubiquitination (GO:0016578)2.77854013
92negative regulation of gene expression, epigenetic (GO:0045814)2.77411710
93dendritic spine organization (GO:0097061)2.76390260
94embryonic camera-type eye morphogenesis (GO:0048596)2.76128620
95central nervous system projection neuron axonogenesis (GO:0021952)2.75586415
96glutamate secretion (GO:0014047)2.75319105
97glucocorticoid receptor signaling pathway (GO:0042921)2.75160702
98negative regulation of histone modification (GO:0031057)2.74764501
99* mRNA splice site selection (GO:0006376)2.74515146
100protein localization to synapse (GO:0035418)2.73703695
101protein localization to chromosome, centromeric region (GO:0071459)2.73658309
102cytoplasmic mRNA processing body assembly (GO:0033962)2.72037454
103protein localization to kinetochore (GO:0034501)2.71997322
104dendrite morphogenesis (GO:0048813)2.70999011
105NLS-bearing protein import into nucleus (GO:0006607)2.70947779
106V(D)J recombination (GO:0033151)2.70580073
107regulation of chromatin binding (GO:0035561)2.70463805
108regulation of histone H3-K4 methylation (GO:0051569)2.69615476
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.69322340
110sodium ion export (GO:0071436)2.69267480
111regulation of spindle checkpoint (GO:0090231)2.68222941
112ATP-dependent chromatin remodeling (GO:0043044)2.68101827
1133-UTR-mediated mRNA stabilization (GO:0070935)2.68001117
114termination of RNA polymerase II transcription (GO:0006369)2.67569906
115regulation of cell cycle checkpoint (GO:1901976)2.67074342
116long-term memory (GO:0007616)2.67015379
117positive regulation of dendrite morphogenesis (GO:0050775)2.66723862
118peptidyl-arginine N-methylation (GO:0035246)2.66024792
119peptidyl-arginine methylation (GO:0018216)2.66024792
120DNA conformation change (GO:0071103)2.65849858
121positive regulation of RNA splicing (GO:0033120)2.64507016
122centrosome localization (GO:0051642)2.64367988
123regulation of clathrin-mediated endocytosis (GO:2000369)2.63464777
124regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63128851
125behavioral defense response (GO:0002209)2.63022221
126behavioral fear response (GO:0001662)2.63022221
127activation of protein kinase A activity (GO:0034199)2.62411480
128regulation of mRNA stability (GO:0043488)2.61526659
129histone acetylation (GO:0016573)2.61461897
130transmission of nerve impulse (GO:0019226)2.60955934
131regulation of dendritic spine development (GO:0060998)2.60525888
132vesicle transport along microtubule (GO:0047496)2.60444839
133synaptic vesicle exocytosis (GO:0016079)2.60037529
134positive regulation of dendritic spine development (GO:0060999)2.58919228
135chromatin silencing (GO:0006342)2.58189092
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.57052986
137peptidyl-threonine phosphorylation (GO:0018107)2.56623889
138paraxial mesoderm development (GO:0048339)2.56406179
139negative regulation of chromatin modification (GO:1903309)2.55893775
140regulation of DNA damage checkpoint (GO:2000001)2.55408595
141peptidyl-arginine modification (GO:0018195)2.55317447
142internal peptidyl-lysine acetylation (GO:0018393)2.54665053
143neuron-neuron synaptic transmission (GO:0007270)2.53816159
144prepulse inhibition (GO:0060134)2.53646910
145regulation of synapse maturation (GO:0090128)2.52483795
146regulation of synaptic vesicle exocytosis (GO:2000300)2.49158125
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48074031
148synaptic vesicle endocytosis (GO:0048488)2.47328662
149ephrin receptor signaling pathway (GO:0048013)2.46635418
150regulation of postsynaptic membrane potential (GO:0060078)2.46457515
151cellular potassium ion homeostasis (GO:0030007)2.45067209
152DNA unwinding involved in DNA replication (GO:0006268)2.44902143
153membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44719588
154gastrulation with mouth forming second (GO:0001702)2.44590792
155peptidyl-arginine omega-N-methylation (GO:0035247)2.43917696
156spliceosomal tri-snRNP complex assembly (GO:0000244)2.42050067
157negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41648581
158negative regulation of translation, ncRNA-mediated (GO:0040033)2.41648581
159regulation of translation, ncRNA-mediated (GO:0045974)2.41648581
160neurotransmitter secretion (GO:0007269)2.41184451
161heterochromatin organization (GO:0070828)2.39971770
162negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.39607337
163regulation of synaptic plasticity (GO:0048167)2.38868702
164peptidyl-threonine modification (GO:0018210)2.38245463
165regulation of RNA export from nucleus (GO:0046831)2.37816562
166histone H4-K16 acetylation (GO:0043984)2.37795634
167nerve growth factor signaling pathway (GO:0038180)2.37513418
168regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36788477
169regulation of translational termination (GO:0006449)2.36311865
170positive regulation of dendrite development (GO:1900006)2.35081658
171regulation of translational fidelity (GO:0006450)2.35062534
172G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.34641347
173fear response (GO:0042596)2.33889635
174embryonic foregut morphogenesis (GO:0048617)2.33562632
175nucleus localization (GO:0051647)2.33008643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31975212
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.36261669
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.24548444
4E2F7_22180533_ChIP-Seq_HELA_Human3.11776569
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.97236615
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.87378144
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.79219179
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68902564
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.63828193
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.38678888
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.37733524
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32590202
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27568131
14ZFP281_27345836_Chip-Seq_ESCs_Mouse2.24691107
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23546666
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.18019197
17YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14095736
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11618783
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09654966
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08913211
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.06836053
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98246480
23MYC_22102868_ChIP-Seq_BL_Human1.97453364
24DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.96583172
25DROSHA_22980978_ChIP-Seq_HELA_Human1.94608764
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92893151
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.90298729
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.82959466
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77585225
30KDM2B_26808549_Chip-Seq_K562_Human1.77307216
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75197799
32REST_21632747_ChIP-Seq_MESCs_Mouse1.74540921
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73028055
34KDM2B_26808549_Chip-Seq_DND41_Human1.72743298
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71063546
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69338875
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69338875
38GATA1_22025678_ChIP-Seq_K562_Human1.65622458
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65601508
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62562636
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.60938885
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.60201330
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59991907
44AR_21909140_ChIP-Seq_LNCAP_Human1.59802992
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.56891731
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54118555
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52456177
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51845737
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.50482047
50CIITA_25753668_ChIP-Seq_RAJI_Human1.48871975
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48000485
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46549320
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46526230
54GBX2_23144817_ChIP-Seq_PC3_Human1.46422640
55CLOCK_20551151_ChIP-Seq_293T_Human1.44787766
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43094928
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.43027601
58CHD1_26751641_Chip-Seq_LNCaP_Human1.42769820
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41615167
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.40703557
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39260428
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.38477413
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38151249
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37069439
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36534909
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.36339862
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.35941741
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34058329
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.33898152
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33766787
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.33751958
72AR_19668381_ChIP-Seq_PC3_Human1.33720482
73TP53_16413492_ChIP-PET_HCT116_Human1.33306755
74ZNF274_21170338_ChIP-Seq_K562_Hela1.33077736
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31519544
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30690014
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30645951
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30020369
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28474222
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27732148
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27674465
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27378675
83ZNF263_19887448_ChIP-Seq_K562_Human1.26884285
84TCF7_22412390_ChIP-Seq_EML_Mouse1.24933979
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24932068
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24632781
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24557923
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23690901
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23386621
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22059980
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21231176
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19777346
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19492654
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18733626
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.17413398
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16781866
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16179511
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14768610
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14643373
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14643373
101CREB1_26743006_Chip-Seq_LNCaP_Human1.14014038
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.13609850
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13213883
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13162415
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12124330
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12045675
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12011755
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09246055
109AR_21572438_ChIP-Seq_LNCaP_Human1.08911797
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.08783299
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08609244
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07516866
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07121136
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06786477
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06595402
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05596930
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.05296376
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04918102
119TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04744522
120SOX9_26525672_Chip-Seq_HEART_Mouse1.04232636
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03336212
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03293581
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02880939
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99046054
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98873294
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98359000
127STAT3_23295773_ChIP-Seq_U87_Human0.97716807
128KDM5A_27292631_Chip-Seq_BREAST_Human0.97534997
129POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97397098
130MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95644354
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.94671383
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.94353874
133AHR_22903824_ChIP-Seq_MCF-7_Human0.92822023
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92524204
135XRN2_22483619_ChIP-Seq_HELA_Human0.92362554
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92207578
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91565334
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90473492
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90473492
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90473492
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.89426182
142WDR5_24793694_ChIP-Seq_LNCAP_Human0.85428610
143STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82093444
144SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81318087
145PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80464657
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80271489
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.78922704
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77439500
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77404534
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77145176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication8.20615474
2MP0004859_abnormal_synaptic_plasticity5.61843598
3MP0003635_abnormal_synaptic_transmissio3.05755953
4MP0003693_abnormal_embryo_hatching2.82505061
5MP0003787_abnormal_imprinting2.74329206
6MP0010234_abnormal_vibrissa_follicle2.65802655
7MP0002063_abnormal_learning/memory/cond2.59586693
8MP0003077_abnormal_cell_cycle2.59322037
9MP0003880_abnormal_central_pattern2.45972192
10MP0004270_analgesia2.45062221
11MP0002009_preneoplasia2.40405623
12MP0009745_abnormal_behavioral_response2.21803351
13MP0003123_paternal_imprinting2.16647029
14MP0000569_abnormal_digit_pigmentation2.16350618
15MP0002822_catalepsy2.16315144
16MP0005187_abnormal_penis_morphology2.14402983
17MP0003121_genomic_imprinting2.05724642
18MP0003705_abnormal_hypodermis_morpholog1.93685619
19MP0008961_abnormal_basal_metabolism1.83541837
20MP0005076_abnormal_cell_differentiation1.82091119
21MP0003283_abnormal_digestive_organ1.80624896
22MP0001346_abnormal_lacrimal_gland1.78855515
23MP0009780_abnormal_chondrocyte_physiolo1.74566365
24MP0003119_abnormal_digestive_system1.73612059
25MP0002572_abnormal_emotion/affect_behav1.72516722
26MP0000537_abnormal_urethra_morphology1.70109107
27MP0002064_seizures1.64188910
28MP0000778_abnormal_nervous_system1.62360664
29MP0003890_abnormal_embryonic-extraembry1.61954523
30MP0004233_abnormal_muscle_weight1.60710430
31MP0009053_abnormal_anal_canal1.56999117
32MP0005409_darkened_coat_color1.56049870
33MP0002909_abnormal_adrenal_gland1.55223668
34MP0001440_abnormal_grooming_behavior1.53617714
35MP0001348_abnormal_lacrimal_gland1.49947881
36MP0004811_abnormal_neuron_physiology1.49862958
37MP0003861_abnormal_nervous_system1.49447393
38MP0010307_abnormal_tumor_latency1.43591377
39MP0002084_abnormal_developmental_patter1.42253493
40MP0003122_maternal_imprinting1.41095195
41MP0002152_abnormal_brain_morphology1.40784482
42MP0002396_abnormal_hematopoietic_system1.39266059
43MP0001486_abnormal_startle_reflex1.37084981
44MP0004808_abnormal_hematopoietic_stem1.36901496
45MP0002184_abnormal_innervation1.34597568
46MP0002653_abnormal_ependyma_morphology1.31476679
47MP0001286_abnormal_eye_development1.28701111
48MP0002557_abnormal_social/conspecific_i1.25981764
49MP0003111_abnormal_nucleus_morphology1.25959319
50MP0009046_muscle_twitch1.25575754
51MP0004264_abnormal_extraembryonic_tissu1.25517006
52MP0005423_abnormal_somatic_nervous1.24389436
53MP0003567_abnormal_fetal_cardiomyocyte1.23889980
54* MP0004197_abnormal_fetal_growth/weight/1.23108173
55MP0004885_abnormal_endolymph1.22921162
56MP0000566_synostosis1.21853377
57MP0008058_abnormal_DNA_repair1.20947382
58MP0001730_embryonic_growth_arrest1.19908110
59MP0002234_abnormal_pharynx_morphology1.19669907
60MP0004145_abnormal_muscle_electrophysio1.19531010
61MP0001672_abnormal_embryogenesis/_devel1.18659984
62MP0005380_embryogenesis_phenotype1.18659984
63MP0000955_abnormal_spinal_cord1.17715589
64MP0002085_abnormal_embryonic_tissue1.15197854
65MP0003941_abnormal_skin_development1.14362307
66MP0008932_abnormal_embryonic_tissue1.13969553
67MP0003221_abnormal_cardiomyocyte_apopto1.13260099
68MP0009672_abnormal_birth_weight1.12379037
69MP0009703_decreased_birth_body1.10639389
70MP0002272_abnormal_nervous_system1.09714425
71MP0004185_abnormal_adipocyte_glucose1.08328163
72MP0002088_abnormal_embryonic_growth/wei1.07821709
73MP0001501_abnormal_sleep_pattern1.07367068
74MP0002697_abnormal_eye_size1.06994328
75MP0008569_lethality_at_weaning1.06936454
76MP0003984_embryonic_growth_retardation1.06860126
77MP0005623_abnormal_meninges_morphology1.06693212
78MP0001177_atelectasis1.06418252
79* MP0002086_abnormal_extraembryonic_tissu1.05072468
80MP0010352_gastrointestinal_tract_polyps1.05019560
81MP0002067_abnormal_sensory_capabilities1.04585693
82MP0001968_abnormal_touch/_nociception1.04473873
83MP0001849_ear_inflammation1.02839863
84MP0003935_abnormal_craniofacial_develop1.01593192
85MP0001293_anophthalmia1.01168089
86MP0008770_decreased_survivor_rate1.00842322
87MP0001697_abnormal_embryo_size0.99291908
88MP0003115_abnormal_respiratory_system0.99074973
89MP0004215_abnormal_myocardial_fiber0.97861214
90MP0002882_abnormal_neuron_morphology0.96743370
91MP0008877_abnormal_DNA_methylation0.96121607
92MP0005394_taste/olfaction_phenotype0.95396037
93MP0005499_abnormal_olfactory_system0.95396037
94MP0002734_abnormal_mechanical_nocicepti0.95255918
95MP0002092_abnormal_eye_morphology0.94689900
96MP0000751_myopathy0.94427262
97MP0004085_abnormal_heartbeat0.94114006
98MP0005621_abnormal_cell_physiology0.93391958
99MP0002081_perinatal_lethality0.93056310
100MP0008995_early_reproductive_senescence0.92955347
101MP0000631_abnormal_neuroendocrine_gland0.92917564
102MP0004133_heterotaxia0.92867426
103MP0010030_abnormal_orbit_morphology0.92387928
104MP0000350_abnormal_cell_proliferation0.92072012
105MP0004924_abnormal_behavior0.91533134
106MP0005386_behavior/neurological_phenoty0.91533134
107MP0005248_abnormal_Harderian_gland0.89085143
108MP0003942_abnormal_urinary_system0.88535697
109MP0005451_abnormal_body_composition0.88383271
110MP0002733_abnormal_thermal_nociception0.87813657
111MP0002066_abnormal_motor_capabilities/c0.87641073
112MP0003329_amyloid_beta_deposits0.87378033
113MP0003937_abnormal_limbs/digits/tail_de0.86774013
114MP0000432_abnormal_head_morphology0.86436260
115MP0003763_abnormal_thymus_physiology0.86082283
116MP0010094_abnormal_chromosome_stability0.85687253
117MP0003315_abnormal_perineum_morphology0.85202765
118MP0002111_abnormal_tail_morphology0.82718650
119MP0001188_hyperpigmentation0.82446825
120MP0000733_abnormal_muscle_development0.82126131
121MP0004087_abnormal_muscle_fiber0.82115101
122MP0004130_abnormal_muscle_cell0.81853239
123MP0003948_abnormal_gas_homeostasis0.81432153
124MP0003943_abnormal_hepatobiliary_system0.81151403
125MP0005666_abnormal_adipose_tissue0.79935355
126MP0003091_abnormal_cell_migration0.79616694
127MP0002080_prenatal_lethality0.79581751
128MP0003385_abnormal_body_wall0.78915971
129MP0000003_abnormal_adipose_tissue0.78758579
130MP0004957_abnormal_blastocyst_morpholog0.78716316
131MP0006292_abnormal_olfactory_placode0.78141724
132MP0002925_abnormal_cardiovascular_devel0.77437454
133MP0003632_abnormal_nervous_system0.76903324
134MP0009278_abnormal_bone_marrow0.75905375
135MP0000313_abnormal_cell_death0.75695179
136MP0010630_abnormal_cardiac_muscle0.75415759
137MP0000428_abnormal_craniofacial_morphol0.74668217
138MP0003137_abnormal_impulse_conducting0.74125473
139* MP0010769_abnormal_survival0.73794561
140MP0001915_intracranial_hemorrhage0.73599532
141MP0003755_abnormal_palate_morphology0.73287613
142MP0005384_cellular_phenotype0.72838955
143MP0005266_abnormal_metabolism0.70882985
144MP0002210_abnormal_sex_determination0.70553966
145MP0001879_abnormal_lymphatic_vessel0.70531719
146MP0008007_abnormal_cellular_replicative0.68784184

Predicted human phenotypes

RankGene SetZ-score
1Upper motor neuron abnormality (HP:0002127)5.32614690
2Abnormality of the anterior horn cell (HP:0006802)4.93705084
3Degeneration of anterior horn cells (HP:0002398)4.93705084
4Conjunctival telangiectasia (HP:0000524)3.71956212
5Focal motor seizures (HP:0011153)3.49955848
6Abnormality of the lower motor neuron (HP:0002366)3.41396821
7Focal seizures (HP:0007359)3.27788268
8Cortical dysplasia (HP:0002539)3.15003913
9Ependymoma (HP:0002888)3.10385879
10Impaired proprioception (HP:0010831)3.09513366
11Dysmetric saccades (HP:0000641)2.96702533
12Abnormality of the vasculature of the conjunctiva (HP:0008054)2.92841322
13Pointed chin (HP:0000307)2.86524626
14Astrocytoma (HP:0009592)2.84522996
15Abnormality of the astrocytes (HP:0100707)2.84522996
16Obsessive-compulsive behavior (HP:0000722)2.83955848
17Hyperacusis (HP:0010780)2.74201120
18Decreased motor nerve conduction velocity (HP:0003431)2.72011054
19Impaired vibration sensation in the lower limbs (HP:0002166)2.70258374
20Visual hallucinations (HP:0002367)2.68862331
21Ankyloglossia (HP:0010296)2.61827603
22Myokymia (HP:0002411)2.60464869
23Volvulus (HP:0002580)2.60283254
24Insomnia (HP:0100785)2.55416773
25Atrophy/Degeneration involving motor neurons (HP:0007373)2.55371511
26Drooling (HP:0002307)2.51293325
27Excessive salivation (HP:0003781)2.51293325
28Impaired smooth pursuit (HP:0007772)2.44578578
29Long eyelashes (HP:0000527)2.44555270
30Pseudobulbar signs (HP:0002200)2.44337305
31Heterotopia (HP:0002282)2.42382550
32Papillary thyroid carcinoma (HP:0002895)2.42210297
33Pelvic girdle muscle weakness (HP:0003749)2.40627657
34Macroorchidism (HP:0000053)2.39397707
35Annular pancreas (HP:0001734)2.39206184
36Abnormality of the fingertips (HP:0001211)2.38955067
37Impaired social interactions (HP:0000735)2.37096544
38Abnormal social behavior (HP:0012433)2.37096544
39Hepatoblastoma (HP:0002884)2.34150139
40Shoulder girdle muscle weakness (HP:0003547)2.33817736
41Urinary bladder sphincter dysfunction (HP:0002839)2.29987674
42Abnormality of oral frenula (HP:0000190)2.27653520
43Curly hair (HP:0002212)2.27534476
44Genetic anticipation (HP:0003743)2.23799912
45Insidious onset (HP:0003587)2.23152575
46Termporal pattern (HP:0011008)2.23152575
47Elfin facies (HP:0004428)2.23144121
48Nephroblastoma (Wilms tumor) (HP:0002667)2.22892259
49High anterior hairline (HP:0009890)2.22406466
50Abnormality of ocular smooth pursuit (HP:0000617)2.22293757
51Bicuspid aortic valve (HP:0001647)2.22265169
52Dysdiadochokinesis (HP:0002075)2.19514572
53Amblyopia (HP:0000646)2.18462711
54Neoplasm of the heart (HP:0100544)2.17540093
55Progressive cerebellar ataxia (HP:0002073)2.17253668
56Resting tremor (HP:0002322)2.16685213
57Poor eye contact (HP:0000817)2.15355689
58Overlapping toe (HP:0001845)2.13610362
59Glioma (HP:0009733)2.10629983
60Urinary urgency (HP:0000012)2.10094653
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10088296
62Short 4th metacarpal (HP:0010044)2.10088296
63Renovascular hypertension (HP:0100817)2.09115850
64Renal duplication (HP:0000075)2.05650923
65Relative macrocephaly (HP:0004482)2.03523018
66Abnormality of the musculature of the pelvis (HP:0001469)2.02869679
67Abnormality of the hip-girdle musculature (HP:0001445)2.02869679
68Embryonal renal neoplasm (HP:0011794)2.02439140
69Arnold-Chiari malformation (HP:0002308)1.99937770
70Amyotrophic lateral sclerosis (HP:0007354)1.99893252
71Clonus (HP:0002169)1.99282643
72Broad-based gait (HP:0002136)1.98740828
73Action tremor (HP:0002345)1.97370840
74Febrile seizures (HP:0002373)1.97234496
75Attention deficit hyperactivity disorder (HP:0007018)1.94506130
76Cystic hygroma (HP:0000476)1.93794120
77Lower limb amyotrophy (HP:0007210)1.93739028
78Depression (HP:0000716)1.93079007
79Increased nuchal translucency (HP:0010880)1.92062090
802-3 toe syndactyly (HP:0004691)1.92016974
81Inappropriate behavior (HP:0000719)1.91792506
82Bowel incontinence (HP:0002607)1.91744066
83Chromsome breakage (HP:0040012)1.89727842
84Hemiparesis (HP:0001269)1.87490764
85Absence seizures (HP:0002121)1.87195954
86Truncus arteriosus (HP:0001660)1.85336987
87Truncal ataxia (HP:0002078)1.85303513
88Deep palmar crease (HP:0006191)1.84638231
89Deep philtrum (HP:0002002)1.83817929
90Gaze-evoked nystagmus (HP:0000640)1.83322055
91Stereotypic behavior (HP:0000733)1.82514019
92Epileptic encephalopathy (HP:0200134)1.82411371
93Hemiplegia (HP:0002301)1.78623385
94Abnormal hair whorl (HP:0010721)1.78494756
95Shallow orbits (HP:0000586)1.78087501
96Abnormality of the 4th metacarpal (HP:0010012)1.77528898
97Abnormal large intestine physiology (HP:0012700)1.76217523
98Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75627454
99Thick eyebrow (HP:0000574)1.75300589
100Oligodactyly (hands) (HP:0001180)1.74916103
101Nuclear cataract (HP:0100018)1.74752074
102Abnormality of the antihelix (HP:0009738)1.74652267
103Gastrointestinal carcinoma (HP:0002672)1.74080455
104Malignant gastrointestinal tract tumors (HP:0006749)1.74080455
105Cafe-au-lait spot (HP:0000957)1.74016114
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.73854862
107Leiomyosarcoma (HP:0100243)1.73549128
108Uterine leiomyosarcoma (HP:0002891)1.73549128
109Autism (HP:0000717)1.73547805
110Generalized tonic-clonic seizures (HP:0002069)1.72278958
111Skull defect (HP:0001362)1.72051272
112Arterial tortuosity (HP:0005116)1.71364785
113Low anterior hairline (HP:0000294)1.71283164
114Sacral dimple (HP:0000960)1.71156883
115Vertebral arch anomaly (HP:0008438)1.70901417
116Broad face (HP:0000283)1.70770441
117Truncal obesity (HP:0001956)1.70526389
118Neonatal hypoglycemia (HP:0001998)1.69381775
119Narrow palate (HP:0000189)1.69310961
120Gastroesophageal reflux (HP:0002020)1.69227159
121Dialeptic seizures (HP:0011146)1.69135467
122Overriding aorta (HP:0002623)1.67420412
123Large earlobe (HP:0009748)1.66164816
124Absent speech (HP:0001344)1.66151112
125Anal stenosis (HP:0002025)1.66099880
126Protruding tongue (HP:0010808)1.64320800
127Acute lymphatic leukemia (HP:0006721)1.63619837
128Radioulnar synostosis (HP:0002974)1.63298434
129Atonic seizures (HP:0010819)1.63279494
130Impaired vibratory sensation (HP:0002495)1.63240364
131Abnormality of the labia minora (HP:0012880)1.62307808
132Trigonocephaly (HP:0000243)1.61952168
133Partial agenesis of the corpus callosum (HP:0001338)1.61884801
134Spinal cord lesions (HP:0100561)1.61486979
135Syringomyelia (HP:0003396)1.61486979
136Scanning speech (HP:0002168)1.60310822
137Aqueductal stenosis (HP:0002410)1.59794239
138Broad thumb (HP:0011304)1.58754869
139Precocious puberty (HP:0000826)1.58602875
140Subacute progressive viral hepatitis (HP:0006572)1.58573269
141Dysmetria (HP:0001310)1.58502979
142Supernumerary ribs (HP:0005815)1.57736280
143Transitional cell carcinoma of the bladder (HP:0006740)1.57546312
144Abnormality of chromosome segregation (HP:0002916)1.57535388
145Urethral obstruction (HP:0000796)1.56688316
146Medulloblastoma (HP:0002885)1.56377696
147Distal lower limb amyotrophy (HP:0008944)1.55929118
148Deviation of the thumb (HP:0009603)1.55374041
149Proximal placement of thumb (HP:0009623)1.55174616
150Long palpebral fissure (HP:0000637)1.55037068
151Neoplasm of the oral cavity (HP:0100649)1.54417394
152Abnormality of the diencephalon (HP:0010662)1.54052713
153Low posterior hairline (HP:0002162)1.54001554
154Neoplasm of striated muscle (HP:0009728)1.53992454
155Sandal gap (HP:0001852)1.53793988
156Hammertoe (HP:0001765)1.53360420
157Hypopigmentation of the fundus (HP:0007894)1.53133198
158Split foot (HP:0001839)1.53121138
159Spina bifida occulta (HP:0003298)1.52976424
160Wide nose (HP:0000445)1.51674110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.00388362
2NTRK33.41269565
3SIK22.97156051
4CDK122.95555322
5MAP3K92.79642748
6BCR2.67709113
7TRIB32.28612642
8PNCK2.28515062
9KSR12.25598455
10PKN22.21285452
11PRPF4B2.20486577
12MAP3K42.17094072
13TNIK2.02916478
14KSR21.91269241
15CASK1.87370251
16BRD41.82247905
17DAPK21.81493305
18TYRO31.79534485
19CDC71.76049475
20MAP3K101.68845706
21NEK91.67532241
22ALK1.64316963
23EEF2K1.59381293
24PAK61.55145034
25YES11.54401846
26MARK11.52353323
27NTRK21.46410766
28MINK11.45246841
29FGFR41.44962922
30SMG11.44669485
31SRPK11.44220531
32PRKD31.40659098
33NEK11.34221072
34PDGFRA1.34219110
35NEK21.30113294
36CAMKK11.29591002
37NEK61.28988752
38STK241.27645099
39CAMK1G1.27372148
40STK38L1.23693681
41SGK4941.23536185
42SGK2231.23536185
43ICK1.23102712
44RIPK11.21322957
45RIPK41.14129241
46LATS11.12996611
47STK381.11205101
48LATS21.10206023
49MAP3K71.05556605
50DYRK31.03532738
51DMPK1.03436979
52PTK61.02665337
53MAP3K21.02272483
54MAP2K41.02110833
55UHMK10.98038243
56DAPK10.97327220
57MKNK10.97259974
58TAF10.95166558
59RET0.94931649
60MAP3K130.93642220
61SGK30.93020334
62CDC42BPA0.91103380
63CDK50.90381787
64MTOR0.89825040
65SGK10.88193080
66TSSK60.85133414
67ATR0.83839702
68TTN0.83567046
69SCYL20.82714534
70CSNK1E0.80978030
71FGFR10.79708683
72SIK10.78953739
73PASK0.78749517
74PLK20.76715860
75TTK0.76575738
76MARK20.76466504
77STK110.76035709
78* CDK40.74008810
79MAPK100.70062218
80RPS6KA40.69494619
81CHEK20.69174647
82FGFR20.69070200
83DYRK1A0.69046037
84CAMK1D0.68926458
85SGK20.68698489
86CHEK10.67397743
87RPS6KB20.67224360
88NTRK10.66104757
89CDK70.63982673
90RPS6KB10.63575933
91TAOK10.63360736
92PRKD20.62716961
93IRAK20.62430235
94CDK20.62323738
95* CDK60.62193511
96MAP3K60.61908837
97RPS6KA30.61104022
98RAF10.60580244
99NLK0.60507137
100CSNK1D0.60283240
101PRKCH0.60201650
102FER0.60132926
103PDGFRB0.59399586
104PRKDC0.59393080
105FGFR30.58849113
106ERBB20.58332887
107MKNK20.57468457
108WNK30.57077331
109EPHB20.56129434
110MELK0.53563456
111PRKAA10.53131407
112PTK20.52955041
113CDK150.52584799
114CDK180.51431783
115PRKCG0.50906602
116GSK3B0.49466089
117CDK10.49102312
118CDK140.48617493
119MAPK140.46903531
120PAK30.46617390
121CSNK1G20.46616131
122ATM0.46253903
123CAMK40.45813866
124CDK90.44174654
125AKT30.43657420
126FGR0.43465774
127AKT20.43157371
128ERBB30.43149003
129RPS6KA10.42454003
130MAP3K140.42449752
131CDK11A0.42389528
132SIK30.41082815
133PTK2B0.41056812
134MAPK80.40982146
135GRK60.40829156
136* AKT10.39570645
137MAPK90.39303571
138PAK20.39094706
139CDK190.38253338

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.59789776
2Nicotine addiction_Homo sapiens_hsa050332.58825842
3Cell cycle_Homo sapiens_hsa041102.17870475
4Amphetamine addiction_Homo sapiens_hsa050311.99192659
5Glutamatergic synapse_Homo sapiens_hsa047241.99121966
6Circadian entrainment_Homo sapiens_hsa047131.95860161
7Dopaminergic synapse_Homo sapiens_hsa047281.76464316
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76461742
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74997075
10Non-homologous end-joining_Homo sapiens_hsa034501.73884135
11Nitrogen metabolism_Homo sapiens_hsa009101.72436328
12Morphine addiction_Homo sapiens_hsa050321.69724264
13Olfactory transduction_Homo sapiens_hsa047401.69512345
14Thyroid cancer_Homo sapiens_hsa052161.67321085
15GABAergic synapse_Homo sapiens_hsa047271.64787153
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62211767
17Pancreatic cancer_Homo sapiens_hsa052121.61882663
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61219547
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60082903
20Spliceosome_Homo sapiens_hsa030401.59675356
21Oxytocin signaling pathway_Homo sapiens_hsa049211.54022797
22Type II diabetes mellitus_Homo sapiens_hsa049301.53683860
23mTOR signaling pathway_Homo sapiens_hsa041501.53399780
24Acute myeloid leukemia_Homo sapiens_hsa052211.51528302
25Salivary secretion_Homo sapiens_hsa049701.48759639
26GnRH signaling pathway_Homo sapiens_hsa049121.48634324
27Insulin secretion_Homo sapiens_hsa049111.48011783
28Prostate cancer_Homo sapiens_hsa052151.47733562
29Long-term depression_Homo sapiens_hsa047301.45408205
30Glioma_Homo sapiens_hsa052141.42634216
31Cholinergic synapse_Homo sapiens_hsa047251.42544412
32Gastric acid secretion_Homo sapiens_hsa049711.42201797
33Estrogen signaling pathway_Homo sapiens_hsa049151.40576245
34Oocyte meiosis_Homo sapiens_hsa041141.40177291
35Prolactin signaling pathway_Homo sapiens_hsa049171.38762142
36Dorso-ventral axis formation_Homo sapiens_hsa043201.37331559
37RNA transport_Homo sapiens_hsa030131.33905877
38Renin secretion_Homo sapiens_hsa049241.32301682
39Gap junction_Homo sapiens_hsa045401.31460555
40Taste transduction_Homo sapiens_hsa047421.30629915
41Cocaine addiction_Homo sapiens_hsa050301.29379704
42B cell receptor signaling pathway_Homo sapiens_hsa046621.25138333
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25028003
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22595104
45Non-small cell lung cancer_Homo sapiens_hsa052231.22414516
46mRNA surveillance pathway_Homo sapiens_hsa030151.20962545
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19397392
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18325057
49ErbB signaling pathway_Homo sapiens_hsa040121.16897119
50Melanogenesis_Homo sapiens_hsa049161.16377196
51Hepatitis B_Homo sapiens_hsa051611.15822404
52Calcium signaling pathway_Homo sapiens_hsa040201.15259498
53Axon guidance_Homo sapiens_hsa043601.14905357
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14849566
55cAMP signaling pathway_Homo sapiens_hsa040241.14260277
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13570030
57DNA replication_Homo sapiens_hsa030301.12134399
58Lysine degradation_Homo sapiens_hsa003101.09942494
59Synaptic vesicle cycle_Homo sapiens_hsa047211.09653263
60Endometrial cancer_Homo sapiens_hsa052131.09160749
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08584925
62Glucagon signaling pathway_Homo sapiens_hsa049221.08127108
63Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04107263
64VEGF signaling pathway_Homo sapiens_hsa043701.03244313
65Viral carcinogenesis_Homo sapiens_hsa052031.01545409
66Basal transcription factors_Homo sapiens_hsa030221.01535055
67Choline metabolism in cancer_Homo sapiens_hsa052311.00372049
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99800242
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.97357558
70Chronic myeloid leukemia_Homo sapiens_hsa052200.97154156
71Dilated cardiomyopathy_Homo sapiens_hsa054140.95470174
72Adherens junction_Homo sapiens_hsa045200.95350910
73Colorectal cancer_Homo sapiens_hsa052100.94170442
74Wnt signaling pathway_Homo sapiens_hsa043100.93030967
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92379192
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91956822
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.91910209
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90156057
79Hippo signaling pathway_Homo sapiens_hsa043900.88311848
80MicroRNAs in cancer_Homo sapiens_hsa052060.87311739
81Serotonergic synapse_Homo sapiens_hsa047260.86130916
82Mismatch repair_Homo sapiens_hsa034300.85032145
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83832963
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83643470
85Small cell lung cancer_Homo sapiens_hsa052220.83334527
86Insulin signaling pathway_Homo sapiens_hsa049100.83289848
87Renal cell carcinoma_Homo sapiens_hsa052110.80140975
88MAPK signaling pathway_Homo sapiens_hsa040100.79745077
89Thyroid hormone synthesis_Homo sapiens_hsa049180.79275005
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.78344623
91TGF-beta signaling pathway_Homo sapiens_hsa043500.78184292
92Rap1 signaling pathway_Homo sapiens_hsa040150.76968821
93Proteoglycans in cancer_Homo sapiens_hsa052050.76512122
94AMPK signaling pathway_Homo sapiens_hsa041520.74511631
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74191378
96Basal cell carcinoma_Homo sapiens_hsa052170.73614369
97Pathways in cancer_Homo sapiens_hsa052000.72113499
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71712936
99HIF-1 signaling pathway_Homo sapiens_hsa040660.71540794
100Insulin resistance_Homo sapiens_hsa049310.71519495
101HTLV-I infection_Homo sapiens_hsa051660.70854527
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.70747846
103Tight junction_Homo sapiens_hsa045300.70095820
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66682760
105p53 signaling pathway_Homo sapiens_hsa041150.66671937
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65389846
107Inositol phosphate metabolism_Homo sapiens_hsa005620.64709381
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64550556
109Bile secretion_Homo sapiens_hsa049760.64437181
110Pancreatic secretion_Homo sapiens_hsa049720.63545506
111Hedgehog signaling pathway_Homo sapiens_hsa043400.63456805
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63039967
113Apoptosis_Homo sapiens_hsa042100.61776851
114Alcoholism_Homo sapiens_hsa050340.61768351
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61414848
116FoxO signaling pathway_Homo sapiens_hsa040680.59716955
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59656001
118Epstein-Barr virus infection_Homo sapiens_hsa051690.58923634
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58171929
120Notch signaling pathway_Homo sapiens_hsa043300.56062791
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54884403
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54466196
123T cell receptor signaling pathway_Homo sapiens_hsa046600.54379775
124Melanoma_Homo sapiens_hsa052180.53357379
125Ras signaling pathway_Homo sapiens_hsa040140.53167905
126Bladder cancer_Homo sapiens_hsa052190.52074192
127Arginine biosynthesis_Homo sapiens_hsa002200.51961624
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51395121
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.51220123
130Focal adhesion_Homo sapiens_hsa045100.50794142
131Circadian rhythm_Homo sapiens_hsa047100.49412588
132Fanconi anemia pathway_Homo sapiens_hsa034600.48633042
133Prion diseases_Homo sapiens_hsa050200.48494997
134Hepatitis C_Homo sapiens_hsa051600.48400262

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