CELF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.93904160
2ionotropic glutamate receptor signaling pathway (GO:0035235)5.66606548
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54895420
4regulation of B cell receptor signaling pathway (GO:0050855)5.52512748
5vocalization behavior (GO:0071625)5.47438083
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45972594
7glutamate receptor signaling pathway (GO:0007215)5.28428928
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.25778530
9protein localization to synapse (GO:0035418)5.11966885
10regulation of glutamate receptor signaling pathway (GO:1900449)5.10814781
11neuron cell-cell adhesion (GO:0007158)5.02524764
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01458095
13locomotory exploration behavior (GO:0035641)4.90334046
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.87246817
15activated T cell proliferation (GO:0050798)4.81409286
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.72837221
17synaptic transmission, glutamatergic (GO:0035249)4.69798830
18synaptic vesicle exocytosis (GO:0016079)4.66113130
19negative thymic T cell selection (GO:0045060)4.60399546
20negative T cell selection (GO:0043383)4.57993204
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43799685
22antigen processing and presentation of endogenous antigen (GO:0019883)4.41173698
23neuron recognition (GO:0008038)4.37314495
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35945682
25neuron-neuron synaptic transmission (GO:0007270)4.34299870
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32816839
27synaptic vesicle maturation (GO:0016188)4.29361801
28exploration behavior (GO:0035640)4.28899747
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.27228260
30positive T cell selection (GO:0043368)4.24904627
31positive regulation by symbiont of host defense response (GO:0052509)4.24021250
32modulation by symbiont of host defense response (GO:0052031)4.24021250
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24021250
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24021250
35positive regulation by organism of defense response of other organism involved in symbiotic interact4.24021250
36modulation by symbiont of host immune response (GO:0052553)4.24021250
37glutamate secretion (GO:0014047)4.21683524
38synaptic vesicle docking involved in exocytosis (GO:0016081)4.19200546
39neurotransmitter-gated ion channel clustering (GO:0072578)4.18097521
40response to interleukin-15 (GO:0070672)4.15044073
41regulation of gamma-delta T cell activation (GO:0046643)4.12864663
42regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11478670
43axonal fasciculation (GO:0007413)4.08167094
44regulation of neuronal synaptic plasticity (GO:0048168)4.06824627
45central nervous system projection neuron axonogenesis (GO:0021952)4.06168199
46cellular response to interleukin-15 (GO:0071350)4.04628404
47positive thymic T cell selection (GO:0045059)4.04576756
48presynaptic membrane assembly (GO:0097105)4.03790480
49long-term memory (GO:0007616)4.03137579
50regulation of dendritic spine morphogenesis (GO:0061001)4.03015418
51positive regulation of synapse maturation (GO:0090129)4.01630780
52regulation of synapse structural plasticity (GO:0051823)4.00984251
53regulation of gamma-delta T cell differentiation (GO:0045586)4.00401480
54regulation of synaptic vesicle exocytosis (GO:2000300)3.98081366
55B cell receptor signaling pathway (GO:0050853)3.96441943
56neutrophil activation involved in immune response (GO:0002283)3.94628402
57positive regulation of B cell differentiation (GO:0045579)3.94139201
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93096349
59neuronal action potential propagation (GO:0019227)3.92915542
60postsynaptic membrane organization (GO:0001941)3.92740364
61dendritic spine morphogenesis (GO:0060997)3.90923174
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.89823780
63regulation of postsynaptic membrane potential (GO:0060078)3.89440830
64negative regulation of T cell mediated immunity (GO:0002710)3.86527932
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.84630442
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.83496821
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.82702312
68layer formation in cerebral cortex (GO:0021819)3.80077453
69positive regulation of granulocyte differentiation (GO:0030854)3.77714341
70microglial cell activation (GO:0001774)3.77103367
71regulation of synaptic vesicle transport (GO:1902803)3.73976252
72leukocyte aggregation (GO:0070486)3.73139655
73regulation of B cell differentiation (GO:0045577)3.71292125
74behavioral defense response (GO:0002209)3.70986572
75behavioral fear response (GO:0001662)3.70986572
76macrophage activation involved in immune response (GO:0002281)3.68677572
77presynaptic membrane organization (GO:0097090)3.66182085
78cellular extravasation (GO:0045123)3.64657723
79regulation of dendritic spine development (GO:0060998)3.62450577
80positive regulation of membrane potential (GO:0045838)3.61282001
81T cell selection (GO:0045058)3.59334039
82T cell migration (GO:0072678)3.59006722
83response to histamine (GO:0034776)3.58789766
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.58277139
85detection of other organism (GO:0098543)3.57234600
86positive regulation of neurotransmitter secretion (GO:0001956)3.54681919
87regulation of synaptic plasticity (GO:0048167)3.54213706
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50898207
89positive regulation of dendritic spine development (GO:0060999)3.49262602
90long-term synaptic potentiation (GO:0060291)3.46389045
91transmission of nerve impulse (GO:0019226)3.45430472
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45407241
93fear response (GO:0042596)3.40523773
94detection of bacterium (GO:0016045)3.38656833
95neurotransmitter secretion (GO:0007269)3.37332597
96gamma-aminobutyric acid transport (GO:0015812)3.36415933
97negative regulation of leukocyte mediated immunity (GO:0002704)3.35570492
98regulation of synapse maturation (GO:0090128)3.35286273
99neutrophil activation (GO:0042119)3.29938164
100dendrite morphogenesis (GO:0048813)3.29509008
101learning (GO:0007612)3.27680381
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27420863
103membrane depolarization (GO:0051899)3.25074329
104synaptic vesicle endocytosis (GO:0048488)3.24144000
105response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23696240
106response to host immune response (GO:0052572)3.23696240
107negative regulation of cell killing (GO:0031342)3.23691684
108negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23691684
109thymic T cell selection (GO:0045061)3.23605052
110regulation of vesicle fusion (GO:0031338)3.20743489
111central nervous system neuron axonogenesis (GO:0021955)3.20384719
112startle response (GO:0001964)3.19415732
113regulation of alpha-beta T cell proliferation (GO:0046640)3.18784070
114tolerance induction (GO:0002507)3.18758780
115positive regulation of mast cell activation (GO:0033005)3.16746669
116positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16271846
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15898110
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14508149
119positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14242546
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11804979
121proline transport (GO:0015824)3.11402571
122detection of external biotic stimulus (GO:0098581)3.09815171
123interferon-gamma production (GO:0032609)3.08146972
124detection of molecule of bacterial origin (GO:0032490)3.07565369
125myeloid cell activation involved in immune response (GO:0002275)3.07372151
126regulation of neurotransmitter secretion (GO:0046928)3.06599889
127negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06397218
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06211982
129neutrophil mediated immunity (GO:0002446)3.05549955
130response to peptidoglycan (GO:0032494)3.05420338
131positive regulation of neurotransmitter transport (GO:0051590)3.04595060
132negative regulation of interleukin-12 production (GO:0032695)3.03645302
133membrane depolarization during action potential (GO:0086010)2.99343698
134mast cell activation (GO:0045576)2.98948856
135synapse assembly (GO:0007416)2.98931338
136positive regulation of synapse assembly (GO:0051965)2.97817248
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97752656
138antigen receptor-mediated signaling pathway (GO:0050851)2.94519196
139cerebellar Purkinje cell differentiation (GO:0021702)2.94083328
140dendritic spine organization (GO:0097061)2.94067046
141macrophage activation (GO:0042116)2.93742306
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93009878
143immunoglobulin mediated immune response (GO:0016064)2.92144254
144regulation of mast cell activation (GO:0033003)2.92123488
145regulation of glutamate secretion (GO:0014048)2.91878714
146response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88526060
147response to host (GO:0075136)2.88526060
148response to host defenses (GO:0052200)2.88526060
149regulation of tolerance induction (GO:0002643)2.87532097
150associative learning (GO:0008306)2.87209081
151response to muramyl dipeptide (GO:0032495)2.87157906
152regulation of germinal center formation (GO:0002634)2.87027024
153regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85560036
154innervation (GO:0060384)2.85541725
155regulation of synapse organization (GO:0050807)2.85443793
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85220352
157regulation of synaptic transmission (GO:0050804)2.85111299
158cerebral cortex radially oriented cell migration (GO:0021799)2.84562355
159negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83861389
160negative regulation of T-helper cell differentiation (GO:0045623)2.83861389
161negative regulation of adaptive immune response (GO:0002820)2.83582740
162Peyers patch development (GO:0048541)2.83260029
163mucosal-associated lymphoid tissue development (GO:0048537)2.83260029
164defense response to protozoan (GO:0042832)2.82755428
165intraspecies interaction between organisms (GO:0051703)2.82465372
166social behavior (GO:0035176)2.82465372
167regulation of granulocyte differentiation (GO:0030852)2.82149724
168positive regulation of synaptic transmission (GO:0050806)2.81950553
169regulation of respiratory system process (GO:0044065)2.81898605
170negative regulation of erythrocyte differentiation (GO:0045647)2.81701127
171myeloid leukocyte mediated immunity (GO:0002444)2.81690750
172cellular potassium ion homeostasis (GO:0030007)2.81411712
173granulocyte activation (GO:0036230)2.81359522
174respiratory burst (GO:0045730)2.80667360
175regulation of synapse assembly (GO:0051963)2.79929402
176regulation of mast cell degranulation (GO:0043304)2.79493177
177regulation of T cell tolerance induction (GO:0002664)2.78745283
178synaptic transmission (GO:0007268)2.78201364
179cerebellar granule cell differentiation (GO:0021707)2.77914527
180negative regulation of dendrite development (GO:2000171)2.77464136
181prepulse inhibition (GO:0060134)2.76944439
182nerve growth factor signaling pathway (GO:0038180)2.76935128
183regulation of regulatory T cell differentiation (GO:0045589)2.76219641
184B cell homeostasis (GO:0001782)2.74985965
185detection of biotic stimulus (GO:0009595)2.74810113
186positive regulation of alpha-beta T cell proliferation (GO:0046641)2.72326808
187germinal center formation (GO:0002467)2.70440786
188regulation of natural killer cell mediated immunity (GO:0002715)2.70211527
189regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70211527
190T cell homeostasis (GO:0043029)2.67369513
191positive regulation of tolerance induction (GO:0002645)2.67216946
192positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67116992
193regulation of mast cell activation involved in immune response (GO:0033006)2.67059590
194T cell proliferation (GO:0042098)2.66613607
195interferon-gamma-mediated signaling pathway (GO:0060333)2.63913145
196positive regulation of mast cell activation involved in immune response (GO:0033008)2.63556176
197positive regulation of mast cell degranulation (GO:0043306)2.63556176
198T cell receptor signaling pathway (GO:0050852)2.59681425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.98816720
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.67486611
3GBX2_23144817_ChIP-Seq_PC3_Human4.30468103
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.16556995
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14115892
6RUNX_20019798_ChIP-Seq_JUKART_Human3.24261775
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05358189
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.00050415
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98870653
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85664519
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82474351
12SCL_19346495_ChIP-Seq_HPC-7_Human2.76414463
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.71449258
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60578936
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57913656
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55630032
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49918346
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49918346
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.46238630
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.44975844
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40856739
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39383573
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.33711594
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33366648
25* MYB_26560356_Chip-Seq_TH2_Human2.31526552
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28612744
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27899224
28* DROSHA_22980978_ChIP-Seq_HELA_Human2.27554874
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.27119115
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25952231
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25654897
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20437245
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18091998
34TAF15_26573619_Chip-Seq_HEK293_Human2.14174280
35EED_16625203_ChIP-ChIP_MESCs_Mouse2.11416324
36RNF2_27304074_Chip-Seq_ESCs_Mouse2.10169829
37AR_21572438_ChIP-Seq_LNCaP_Human2.03246222
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03010001
39* EZH2_27294783_Chip-Seq_ESCs_Mouse2.01816107
40VDR_24787735_ChIP-Seq_THP-1_Human1.99897262
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97867895
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97194871
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97075285
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90785194
45* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90599350
46* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90467057
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88570779
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84692665
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.84054989
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.80827838
51SMAD4_21799915_ChIP-Seq_A2780_Human1.76899986
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76381814
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76218354
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.73163727
55SPI1_23127762_ChIP-Seq_K562_Human1.72693918
56* VDR_24763502_ChIP-Seq_THP-1_Human1.72122627
57P300_19829295_ChIP-Seq_ESCs_Human1.70243829
58IGF1R_20145208_ChIP-Seq_DFB_Human1.69542027
59* SPI1_23547873_ChIP-Seq_NB4_Human1.67458982
60* MYB_26560356_Chip-Seq_TH1_Human1.64522463
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64364327
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61761488
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57941038
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56008294
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55933778
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54911282
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50623988
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49555372
69FUS_26573619_Chip-Seq_HEK293_Human1.48626087
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.47912107
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46663035
72* MAF_26560356_Chip-Seq_TH1_Human1.45488125
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45255489
74AR_25329375_ChIP-Seq_VCAP_Human1.43969156
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.41951592
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40213262
77* GATA3_26560356_Chip-Seq_TH2_Human1.39337359
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38425996
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38001752
80* UTX_26944678_Chip-Seq_JUKART_Human1.36588810
81* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36003992
82* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35830240
83STAT3_23295773_ChIP-Seq_U87_Human1.33554685
84* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33412255
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.32421796
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31696780
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31690871
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31515167
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30060372
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29011381
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27916270
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27537615
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24895463
94TCF4_23295773_ChIP-Seq_U87_Human1.24363128
95* VDR_21846776_ChIP-Seq_THP-1_Human1.23938803
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.22621154
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.22570149
98* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22317159
99* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22317159
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21182910
101* PRDM14_20953172_ChIP-Seq_ESCs_Human1.20332904
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20131583
103AR_19668381_ChIP-Seq_PC3_Human1.19559892
104GATA1_22025678_ChIP-Seq_K562_Human1.18970625
105* ZNF274_21170338_ChIP-Seq_K562_Hela1.18746544
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18661072
107TP53_16413492_ChIP-PET_HCT116_Human1.18542579
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18303866
109* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16873602
110RNF2_27304074_Chip-Seq_NSC_Mouse1.16149345
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.15746282
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15085819
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.14996129
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14646886
115* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14126263
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13367162
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.13153197
118* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12004701
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11805781
120* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11154071
121* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10993136
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10630689
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10318266
124TP53_18474530_ChIP-ChIP_U2OS_Human1.08873802
125RUNX2_22187159_ChIP-Seq_PCA_Human1.07487167
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07143484
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06527271
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05020987
129MYC_22102868_ChIP-Seq_BL_Human1.04938735
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04665154
131AHR_22903824_ChIP-Seq_MCF-7_Human1.02529968
132EWS_26573619_Chip-Seq_HEK293_Human1.02290167
133MAF_26560356_Chip-Seq_TH2_Human1.01687189
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01536504
135FLI1_27457419_Chip-Seq_LIVER_Mouse1.01118801
136JUN_21703547_ChIP-Seq_K562_Human1.01101926
137* SMRT_27268052_Chip-Seq_Bcells_Human1.00110655
138* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99435199
139* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99268603
140CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97697275
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96208420
142* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96167886
143* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95736688
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94431682
145KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.94375593
146* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93844591
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.93818875
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.93733131
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93685699
150ER_23166858_ChIP-Seq_MCF-7_Human0.93613624
151* KDM2B_26808549_Chip-Seq_DND41_Human0.93206033
152* P53_22387025_ChIP-Seq_ESCs_Mouse0.92937695
153* TCF7_22412390_ChIP-Seq_EML_Mouse0.92829216
154BCAT_22108803_ChIP-Seq_LS180_Human0.92502852
155* CMYC_18555785_Chip-Seq_ESCs_Mouse0.91490008
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91439928
157PU_27001747_Chip-Seq_BMDM_Mouse0.91093288
158KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89356195
159GATA1_19941826_ChIP-Seq_K562_Human0.85297976
160* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84187308
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82786233
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81041011
163GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78609515
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78363935
165ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77549061
166SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77400409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.67022653
2MP0003880_abnormal_central_pattern5.52681079
3MP0003635_abnormal_synaptic_transmissio4.14807811
4MP0003724_increased_susceptibility_to4.06245386
5MP0001835_abnormal_antigen_presentation3.72128897
6MP0009745_abnormal_behavioral_response3.53389355
7MP0002063_abnormal_learning/memory/cond3.46702343
8MP0004270_analgesia3.31956233
9MP0003436_decreased_susceptibility_to3.27016591
10MP0005671_abnormal_response_to3.24360326
11MP0001968_abnormal_touch/_nociception3.24188615
12MP0002064_seizures2.94917072
13MP0001800_abnormal_humoral_immune2.93812953
14MP0002572_abnormal_emotion/affect_behav2.89852573
15MP0003763_abnormal_thymus_physiology2.89557735
16MP0005423_abnormal_somatic_nervous2.84328932
17MP0002736_abnormal_nociception_after2.61629633
18MP0002735_abnormal_chemical_nociception2.60665684
19MP0005000_abnormal_immune_tolerance2.56930047
20MP0009046_muscle_twitch2.47950350
21MP0002723_abnormal_immune_serum2.43900791
22MP0002420_abnormal_adaptive_immunity2.42765059
23MP0001486_abnormal_startle_reflex2.41691685
24MP0002419_abnormal_innate_immunity2.39380238
25MP0001819_abnormal_immune_cell2.37884072
26MP0002272_abnormal_nervous_system2.34996733
27MP0005025_abnormal_response_to2.32545181
28MP0001790_abnormal_immune_system2.31668894
29MP0005387_immune_system_phenotype2.31668894
30MP0000685_abnormal_immune_system2.30457064
31MP0002734_abnormal_mechanical_nocicepti2.25821432
32MP0002452_abnormal_antigen_presenting2.24455955
33MP0002822_catalepsy2.21736976
34MP0001501_abnormal_sleep_pattern2.20824022
35MP0000778_abnormal_nervous_system2.16772203
36MP0001440_abnormal_grooming_behavior2.15012156
37MP0000465_gastrointestinal_hemorrhage2.10241837
38MP0002398_abnormal_bone_marrow2.08013711
39MP0009785_altered_susceptibility_to2.07092561
40MP0001188_hyperpigmentation2.01398998
41MP0003787_abnormal_imprinting2.00634174
42MP0002067_abnormal_sensory_capabilities2.00459955
43MP0000569_abnormal_digit_pigmentation1.98880874
44MP0005464_abnormal_platelet_physiology1.97761130
45MP0000716_abnormal_immune_system1.91534979
46MP0002733_abnormal_thermal_nociception1.90257047
47MP0001970_abnormal_pain_threshold1.81105513
48MP0002184_abnormal_innervation1.80054997
49MP0002148_abnormal_hypersensitivity_rea1.78940822
50MP0002557_abnormal_social/conspecific_i1.77214800
51MP0008569_lethality_at_weaning1.76883832
52MP0002405_respiratory_system_inflammati1.75735012
53MP0006276_abnormal_autonomic_nervous1.71855499
54MP0002396_abnormal_hematopoietic_system1.70452400
55MP0005386_behavior/neurological_phenoty1.69866607
56MP0004924_abnormal_behavior1.69866607
57MP0000703_abnormal_thymus_morphology1.69082038
58MP0000689_abnormal_spleen_morphology1.65182050
59MP0004811_abnormal_neuron_physiology1.63364793
60MP0003300_gastrointestinal_ulcer1.60870146
61MP0005409_darkened_coat_color1.57768134
62MP0002722_abnormal_immune_system1.56976602
63MP0006082_CNS_inflammation1.56160610
64MP0003866_abnormal_defecation1.55399961
65MP0001984_abnormal_olfaction1.53153802
66MP0003879_abnormal_hair_cell1.51687206
67MP0003172_abnormal_lysosome_physiology1.46381458
68MP0006292_abnormal_olfactory_placode1.46271267
69MP0005646_abnormal_pituitary_gland1.46072065
70MP0009780_abnormal_chondrocyte_physiolo1.42677051
71MP0002429_abnormal_blood_cell1.41076695
72MP0002909_abnormal_adrenal_gland1.39502659
73MP0004381_abnormal_hair_follicle1.37601291
74MP0001529_abnormal_vocalization1.37113352
75MP0009278_abnormal_bone_marrow1.36691022
76MP0000955_abnormal_spinal_cord1.36585199
77MP0001851_eye_inflammation1.34203026
78MP0002882_abnormal_neuron_morphology1.32746952
79MP0001986_abnormal_taste_sensitivity1.31780693
80MP0001533_abnormal_skeleton_physiology1.31269225
81MP0003828_pulmonary_edema1.31052731
82MP0001502_abnormal_circadian_rhythm1.31031184
83MP0001905_abnormal_dopamine_level1.29591827
84MP0001545_abnormal_hematopoietic_system1.28930648
85MP0005397_hematopoietic_system_phenotyp1.28930648
86MP0002066_abnormal_motor_capabilities/c1.28378013
87MP0000015_abnormal_ear_pigmentation1.27099721
88MP0001845_abnormal_inflammatory_respons1.24273331
89MP0003690_abnormal_glial_cell1.22512298
90MP0004883_abnormal_blood_vessel1.22322586
91MP0003329_amyloid_beta_deposits1.21486090
92MP0010155_abnormal_intestine_physiology1.20056164
93MP0005310_abnormal_salivary_gland1.17335217
94MP0004510_myositis1.16570407
95MP0005075_abnormal_melanosome_morpholog1.16331401
96MP0002166_altered_tumor_susceptibility1.15427512
97MP0004858_abnormal_nervous_system1.14446968
98MP0003633_abnormal_nervous_system1.13074477
99MP0005645_abnormal_hypothalamus_physiol1.10262714
100MP0004130_abnormal_muscle_cell1.10035550
101MP0002152_abnormal_brain_morphology1.10009565
102MP0005174_abnormal_tail_pigmentation1.07101130
103MP0002876_abnormal_thyroid_physiology1.06285363
104MP0009333_abnormal_splenocyte_physiolog1.05401294
105MP0004885_abnormal_endolymph1.03849792
106MP0004142_abnormal_muscle_tone1.02202753
107MP0002277_abnormal_respiratory_mucosa1.01817686
108MP0004808_abnormal_hematopoietic_stem1.00719495
109MP0009764_decreased_sensitivity_to1.00164451
110MP0003631_nervous_system_phenotype0.94789434
111MP0004742_abnormal_vestibular_system0.93427398
112MP0002102_abnormal_ear_morphology0.92895738
113MP0002009_preneoplasia0.92132176
114MP0005551_abnormal_eye_electrophysiolog0.91926315
115MP0004145_abnormal_muscle_electrophysio0.86908433
116MP0008260_abnormal_autophagy0.86896763
117MP0008874_decreased_physiological_sensi0.86579604
118MP0000631_abnormal_neuroendocrine_gland0.86389173
119MP0002069_abnormal_eating/drinking_beha0.85884255
120MP0000751_myopathy0.85566058
121MP0004947_skin_inflammation0.83539378
122MP0008469_abnormal_protein_level0.81853357
123MP0008961_abnormal_basal_metabolism0.80408675
124MP0002638_abnormal_pupillary_reflex0.78910609
125MP0004085_abnormal_heartbeat0.77992099
126MP0001963_abnormal_hearing_physiology0.77706565
127MP0002998_abnormal_bone_remodeling0.75612263
128MP0001663_abnormal_digestive_system0.75388547
129MP0004484_altered_response_of0.73632351
130MP0010386_abnormal_urinary_bladder0.72448180
131MP0002229_neurodegeneration0.72444960
132MP0001177_atelectasis0.71692053
133MP0000920_abnormal_myelination0.70647565
134MP0002752_abnormal_somatic_nervous0.70258605
135MP0000604_amyloidosis0.68972412
136MP0008995_early_reproductive_senescence0.68884457
137MP0005535_abnormal_body_temperature0.68621847
138MP0002133_abnormal_respiratory_system0.67772031
139MP0005388_respiratory_system_phenotype0.67772031
140MP0003075_altered_response_to0.67717980
141MP0002928_abnormal_bile_duct0.67510617
142MP0002837_dystrophic_cardiac_calcinosis0.66436010
143MP0005171_absent_coat_pigmentation0.66323541
144MP0008872_abnormal_physiological_respon0.65600991
145MP0003861_abnormal_nervous_system0.63762192
146MP0004215_abnormal_myocardial_fiber0.63663711
147MP0003045_fibrosis0.63319823
148MP0003137_abnormal_impulse_conducting0.63110987
149MP0005499_abnormal_olfactory_system0.62944305
150MP0005394_taste/olfaction_phenotype0.62944305
151MP0002132_abnormal_respiratory_system0.62534924
152MP0003303_peritoneal_inflammation0.58350814
153MP0008877_abnormal_DNA_methylation0.58337303
154MP0003632_abnormal_nervous_system0.58321388
155MP0000026_abnormal_inner_ear0.57357630
156MP0002234_abnormal_pharynx_morphology0.55397651
157MP0003122_maternal_imprinting0.54727272
158MP0001485_abnormal_pinna_reflex0.54441777
159MP0010769_abnormal_survival0.53723056
160MP0001664_abnormal_digestion0.53533576
161MP0002095_abnormal_skin_pigmentation0.53077235
162MP0010770_preweaning_lethality0.52773318
163MP0002082_postnatal_lethality0.52773318
164MP0010768_mortality/aging0.51221574
165MP0003183_abnormal_peptide_metabolism0.50401838
166MP0003634_abnormal_glial_cell0.48361286

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.31722965
2Focal seizures (HP:0007359)5.52973442
3Epileptic encephalopathy (HP:0200134)5.19008192
4Myokymia (HP:0002411)5.18508548
5Stomatitis (HP:0010280)4.72912968
6Febrile seizures (HP:0002373)4.69942322
7Visual hallucinations (HP:0002367)4.68369627
8Eczematoid dermatitis (HP:0000976)4.67754503
9Broad-based gait (HP:0002136)4.63041493
10Recurrent bacterial skin infections (HP:0005406)4.52580004
11Hyperventilation (HP:0002883)4.49280747
12Myositis (HP:0100614)4.46927170
13Elevated erythrocyte sedimentation rate (HP:0003565)4.42851026
14Recurrent abscess formation (HP:0002722)4.40801504
15Progressive cerebellar ataxia (HP:0002073)4.16407998
16Recurrent fungal infections (HP:0002841)4.07043045
17Atonic seizures (HP:0010819)4.06973791
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.04872534
19T lymphocytopenia (HP:0005403)3.99800415
20Retrobulbar optic neuritis (HP:0100654)3.94330993
21Optic neuritis (HP:0100653)3.94330993
22Panhypogammaglobulinemia (HP:0003139)3.83058082
23Absence seizures (HP:0002121)3.81393467
24Abnormality of T cell number (HP:0011839)3.81289874
25Orchitis (HP:0100796)3.79278631
26Chronic mucocutaneous candidiasis (HP:0002728)3.69109460
27Recurrent cutaneous fungal infections (HP:0011370)3.69109460
28Meningitis (HP:0001287)3.66361279
29Encephalitis (HP:0002383)3.64681922
30Dialeptic seizures (HP:0011146)3.63280987
31Spontaneous hematomas (HP:0007420)3.56092884
32Papilledema (HP:0001085)3.52662203
33Poor eye contact (HP:0000817)3.52492733
34Excessive salivation (HP:0003781)3.49941704
35Drooling (HP:0002307)3.49941704
36Protruding tongue (HP:0010808)3.45493103
37Mediastinal lymphadenopathy (HP:0100721)3.42295731
38Gaze-evoked nystagmus (HP:0000640)3.41994712
39Prolonged bleeding time (HP:0003010)3.40803915
40Gastrointestinal infarctions (HP:0005244)3.39227844
41Generalized tonic-clonic seizures (HP:0002069)3.36742334
42Amblyopia (HP:0000646)3.30393226
43Recurrent skin infections (HP:0001581)3.26946064
44Stereotypic behavior (HP:0000733)3.18842262
45Chest pain (HP:0100749)3.17444163
46Hypochromic microcytic anemia (HP:0004840)3.14730299
47Inappropriate behavior (HP:0000719)3.11423000
48Vasculitis (HP:0002633)3.10911570
49Abnormality of T cells (HP:0002843)3.08485137
50Genetic anticipation (HP:0003743)3.06852503
51Absent speech (HP:0001344)3.02494106
52Chronic obstructive pulmonary disease (HP:0006510)3.00347395
53Obstructive lung disease (HP:0006536)3.00347395
54Leukocytosis (HP:0001974)2.99230534
55Recurrent viral infections (HP:0004429)2.98729763
56Keratoconjunctivitis sicca (HP:0001097)2.98217419
57Abnormality of macrophages (HP:0004311)2.96889246
58Truncal ataxia (HP:0002078)2.96761048
59Impaired social interactions (HP:0000735)2.93951328
60Abnormal social behavior (HP:0012433)2.93951328
61Abnormality of binocular vision (HP:0011514)2.89961395
62Diplopia (HP:0000651)2.89961395
63Recurrent gram-negative bacterial infections (HP:0005420)2.89382237
64Keratoconjunctivitis (HP:0001096)2.86845373
65Agammaglobulinemia (HP:0004432)2.86815555
66Supranuclear gaze palsy (HP:0000605)2.85887493
67Progressive inability to walk (HP:0002505)2.81967654
68Fair hair (HP:0002286)2.78992161
69Stomach cancer (HP:0012126)2.78237867
70Inability to walk (HP:0002540)2.78168993
71Dysdiadochokinesis (HP:0002075)2.73026226
72Mutism (HP:0002300)2.72324987
73Granulocytopenia (HP:0001913)2.68957195
74Generalized hypopigmentation of hair (HP:0011358)2.68359542
75Severe combined immunodeficiency (HP:0004430)2.68228216
76Impaired vibration sensation in the lower limbs (HP:0002166)2.67069193
77Pulmonary infiltrates (HP:0002113)2.65226528
78Hemoptysis (HP:0002105)2.65026922
79Action tremor (HP:0002345)2.64645487
80Epistaxis (HP:0000421)2.62873162
81Eosinophilia (HP:0001880)2.61114358
82Increased IgE level (HP:0003212)2.57793683
83Obstructive sleep apnea (HP:0002870)2.55822757
84Abnormality of eosinophils (HP:0001879)2.55369366
85Impaired smooth pursuit (HP:0007772)2.55041724
86Gingival bleeding (HP:0000225)2.54750102
87Exotropia (HP:0000577)2.54415307
88Chronic otitis media (HP:0000389)2.54180647
89Urinary bladder sphincter dysfunction (HP:0002839)2.51408444
90Dysmetria (HP:0001310)2.50726797
91Depression (HP:0000716)2.48042505
92Recurrent bronchitis (HP:0002837)2.47671178
93Amyotrophic lateral sclerosis (HP:0007354)2.47374397
94Widely spaced teeth (HP:0000687)2.46201908
95Epileptiform EEG discharges (HP:0011182)2.45876778
96Abnormal eating behavior (HP:0100738)2.41934200
97Hypochromic anemia (HP:0001931)2.40941064
98Urticaria (HP:0001025)2.39874925
99Inflammation of the large intestine (HP:0002037)2.38429222
100Pulmonary embolism (HP:0002204)2.37908086
101Hemiparesis (HP:0001269)2.36612400
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35767105
103Gingivitis (HP:0000230)2.33314952
104Abnormality of salivation (HP:0100755)2.32043259
105Abnormality of B cell number (HP:0010975)2.31928148
106Blue irides (HP:0000635)2.30786909
107Cellulitis (HP:0100658)2.29075561
108Arterial thrombosis (HP:0004420)2.28097001
109Anxiety (HP:0000739)2.25261532
110Autoimmune hemolytic anemia (HP:0001890)2.25232811
111Abnormality of T cell physiology (HP:0011840)2.24890266
112Gastrointestinal inflammation (HP:0004386)2.22642343
113IgG deficiency (HP:0004315)2.20648314
114Abnormality of ocular smooth pursuit (HP:0000617)2.20296803
115Fetal akinesia sequence (HP:0001989)2.20057340
116Polyphagia (HP:0002591)2.20053627
117Increased IgM level (HP:0003496)2.19851102
118Scanning speech (HP:0002168)2.19728413
119Neoplasm of the tracheobronchial system (HP:0100552)2.18905747
120Lymphopenia (HP:0001888)2.18381618
121EEG with generalized epileptiform discharges (HP:0011198)2.14884466
122Pustule (HP:0200039)2.14160660
123Agitation (HP:0000713)2.13594818
124Lower limb amyotrophy (HP:0007210)2.12974043
125Tented upper lip vermilion (HP:0010804)2.12843578
126Deeply set eye (HP:0000490)2.11273469
127Sepsis (HP:0100806)2.10909775
128Viral hepatitis (HP:0006562)2.10295262
129Hemiplegia (HP:0002301)2.08919255
130Microcytic anemia (HP:0001935)2.06839042
131Episodic fever (HP:0001954)2.05770673
132Intellectual disability, severe (HP:0010864)2.03657823
133Thyroiditis (HP:0100646)2.02563107
134Postural instability (HP:0002172)2.02371180
135Abnormality of the pleura (HP:0002103)2.01905337
136IgM deficiency (HP:0002850)2.01110495
137Pointed chin (HP:0000307)1.99565254
138Alveolar cell carcinoma (HP:0006519)1.98720720
139Palpebral edema (HP:0100540)1.98720134
140Abnormality of cells of the lymphoid lineage (HP:0012140)1.97820990
141Autism (HP:0000717)1.97454554
142Osteomyelitis (HP:0002754)1.96683288
143Urinary urgency (HP:0000012)1.96670672
144B lymphocytopenia (HP:0010976)1.96517890
145Vertigo (HP:0002321)1.95927833
146Abnormality of the prostate (HP:0008775)1.93346973
147Hypsarrhythmia (HP:0002521)1.92705332
148Papilloma (HP:0012740)1.92441380
149Verrucae (HP:0200043)1.92441380
150Ankle clonus (HP:0011448)1.92311162
151Colitis (HP:0002583)1.92305986
152Acute lymphatic leukemia (HP:0006721)1.91347198
153Cerebral inclusion bodies (HP:0100314)1.90898932
154Abnormality of the lower motor neuron (HP:0002366)1.90564944
155Combined immunodeficiency (HP:0005387)1.90290963
156Lower limb asymmetry (HP:0100559)1.89194624
157Thickened helices (HP:0000391)1.89043282
158Abnormality of the heme biosynthetic pathway (HP:0010472)1.86763444
159Slow saccadic eye movements (HP:0000514)1.85912047
160Open mouth (HP:0000194)1.85637313
161Gastroesophageal reflux (HP:0002020)1.85317438
162Bradykinesia (HP:0002067)1.84823843
163Recurrent sinusitis (HP:0011108)1.84623998
164Abnormal hair whorl (HP:0010721)1.83095021
165Obsessive-compulsive behavior (HP:0000722)1.83042506
166Decreased circulating renin level (HP:0003351)1.82199391
167Akinesia (HP:0002304)1.80703117
168Macroglossia (HP:0000158)1.80544035
169Spastic gait (HP:0002064)1.79997575
170Sporadic (HP:0003745)1.79960346
171Limb dystonia (HP:0002451)1.79281864
172Aqueductal stenosis (HP:0002410)1.78543345
173Heterochromia iridis (HP:0001100)1.78314562
174Lissencephaly (HP:0001339)1.77166890
175Gait imbalance (HP:0002141)1.76154546
176Sleep apnea (HP:0010535)1.74503709
177Hypoplasia of the brainstem (HP:0002365)1.74370892
178Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74370892
179Clumsiness (HP:0002312)1.74223023
180Apathy (HP:0000741)1.73552661
181Dysmetric saccades (HP:0000641)1.71219578
182Generalized myoclonic seizures (HP:0002123)1.70064084
183Incomplete penetrance (HP:0003829)1.70011882
184Impaired vibratory sensation (HP:0002495)1.69651017
185Neurofibrillary tangles (HP:0002185)1.68675767
186Termporal pattern (HP:0011008)1.66650989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.29956035
2NTRK35.02802591
3MARK13.82870296
4MAP4K13.48882991
5TAOK33.12873009
6RIPK42.99094591
7MAP2K72.77789916
8TNIK2.75028540
9MAP3K42.73772796
10SIK22.71523909
11MAP3K92.57350792
12BLK2.31248092
13CASK2.26849755
14MINK12.24392621
15KSR12.15342140
16MAP3K122.13301185
17PRPF4B2.12678604
18NTRK22.08331758
19DAPK22.03816348
20BTK2.00644307
21MAPK131.94626103
22FES1.91377482
23TYK21.89208386
24TEC1.86685319
25DAPK11.75692218
26CSK1.73593658
27IRAK41.69441974
28ITK1.63720428
29PLK21.60073242
30IKBKE1.54958357
31MAP2K41.51935938
32ZAP701.47173401
33JAK11.45267140
34SIK31.44991710
35KIT1.44295489
36CDK51.38746087
37LYN1.38628743
38JAK31.38558904
39CAMKK11.32948364
40PAK61.31103302
41BMPR21.28904720
42LCK1.28074532
43MAP3K141.27499148
44MAP3K131.26631633
45KSR21.25390388
46MAP2K31.22677127
47JAK21.19120387
48CAMKK21.14305642
49CCNB11.12633702
50PNCK1.10985206
51CSF1R1.07711039
52CDK191.07242227
53EPHA31.03706355
54MAP3K61.01978713
55SGK21.01847188
56CAMK2A1.01216218
57PRKCG0.99511487
58YES10.98718399
59MARK20.96472145
60MARK30.95899994
61IRAK10.95610266
62RAF10.92799674
63FRK0.91914898
64CAMK2B0.91438953
65CAMK10.90207434
66DYRK1A0.89512873
67GRK50.89182816
68PIK3CG0.84422511
69MAPK70.83247033
70CSNK1G20.82813831
71SGK10.82601744
72UHMK10.80911191
73PTK2B0.80509498
74EPHB10.77531089
75CDK180.76960544
76TAOK20.76569955
77MATK0.75341117
78HIPK20.74706554
79TBK10.74497135
80FGFR30.73060196
81STK110.72619043
82IRAK20.72227770
83FGR0.70802371
84CDK150.69908989
85SGK2230.69213752
86SGK4940.69213752
87SGK30.69086024
88MAP3K110.67124907
89TYRO30.65594917
90CAMK1G0.65261828
91PINK10.65167828
92PIM10.64809514
93NLK0.64718803
94IKBKB0.64713250
95TNK20.64080363
96SYK0.63875588
97STK380.63807388
98CDK140.63482683
99PHKG20.63324790
100PHKG10.63324790
101MAP3K10.61363984
102CDK11A0.61289639
103ERBB30.60140215
104BRD40.58478027
105DMPK0.56252373
106PRKCE0.52946079
107MAP3K50.52192666
108RET0.51906225
109MAP3K20.49835485
110PRKD30.49192798
111PRKCZ0.49078235
112DYRK1B0.48894745
113CAMK40.48875210
114PDK10.48865823
115CDK30.48721501
116FYN0.48563475
117MAPK120.47739794
118ARAF0.47368675
119MUSK0.46330355
120GRK60.45617187
121GRK70.44321221
122TXK0.43431992
123HCK0.43401282
124NTRK10.43093557
125MAP3K70.40654375
126TAOK10.40518999
127RPS6KA40.40387898
128WNK10.40078831
129MAPK40.39231695
130PDPK10.38311310
131NME10.38266012
132PAK30.37356729
133PRKCQ0.37237535
134PRKCH0.36371017
135RPS6KA30.35967381
136PRKG10.34102105
137MAPK100.33705184
138PRKD20.33530252
139ADRBK20.32690785
140CAMK2D0.32141908
141PRKCB0.31646463
142DYRK20.29616664
143FGFR20.28219232
144RPS6KA20.28067300
145RPS6KB10.27925329

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98584261
2Long-term potentiation_Homo sapiens_hsa047202.87644693
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77188255
4Circadian entrainment_Homo sapiens_hsa047132.75942109
5Glutamatergic synapse_Homo sapiens_hsa047242.73674383
6Morphine addiction_Homo sapiens_hsa050322.55051675
7Primary immunodeficiency_Homo sapiens_hsa053402.52819491
8Olfactory transduction_Homo sapiens_hsa047402.42916760
9Amphetamine addiction_Homo sapiens_hsa050312.39552959
10Graft-versus-host disease_Homo sapiens_hsa053322.38189884
11GABAergic synapse_Homo sapiens_hsa047272.35928916
12Allograft rejection_Homo sapiens_hsa053302.32425327
13Synaptic vesicle cycle_Homo sapiens_hsa047212.25798034
14Leishmaniasis_Homo sapiens_hsa051402.24996538
15Autoimmune thyroid disease_Homo sapiens_hsa053202.17251106
16Dopaminergic synapse_Homo sapiens_hsa047282.15338456
17Salivary secretion_Homo sapiens_hsa049701.96772327
18Taste transduction_Homo sapiens_hsa047421.92564741
19Long-term depression_Homo sapiens_hsa047301.85419681
20Renin secretion_Homo sapiens_hsa049241.82129481
21Cholinergic synapse_Homo sapiens_hsa047251.81499084
22Staphylococcus aureus infection_Homo sapiens_hsa051501.78960737
23Serotonergic synapse_Homo sapiens_hsa047261.78508578
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77857096
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.75047094
26Oxytocin signaling pathway_Homo sapiens_hsa049211.73472482
27Calcium signaling pathway_Homo sapiens_hsa040201.72694067
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69378671
29Asthma_Homo sapiens_hsa053101.66020820
30Cocaine addiction_Homo sapiens_hsa050301.58337144
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54258858
32Gastric acid secretion_Homo sapiens_hsa049711.53009996
33Insulin secretion_Homo sapiens_hsa049111.50638329
34Measles_Homo sapiens_hsa051621.49745119
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45450397
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42453570
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41112932
38Hematopoietic cell lineage_Homo sapiens_hsa046401.41112538
39Viral myocarditis_Homo sapiens_hsa054161.40129405
40Antigen processing and presentation_Homo sapiens_hsa046121.39269784
41Axon guidance_Homo sapiens_hsa043601.38236194
42cAMP signaling pathway_Homo sapiens_hsa040241.35776157
43GnRH signaling pathway_Homo sapiens_hsa049121.35213040
44Acute myeloid leukemia_Homo sapiens_hsa052211.32279017
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28922158
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27835440
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.25359062
48Gap junction_Homo sapiens_hsa045401.21967955
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.19707873
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18748680
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14142611
52Glioma_Homo sapiens_hsa052141.14001435
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13170701
54ErbB signaling pathway_Homo sapiens_hsa040121.08409401
55Toxoplasmosis_Homo sapiens_hsa051451.08154263
56Type II diabetes mellitus_Homo sapiens_hsa049301.07436281
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06314540
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05977272
59Influenza A_Homo sapiens_hsa051641.05426966
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04839760
61Malaria_Homo sapiens_hsa051441.02935400
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02403211
63Estrogen signaling pathway_Homo sapiens_hsa049151.01191922
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00853363
65Herpes simplex infection_Homo sapiens_hsa051680.99240360
66Phototransduction_Homo sapiens_hsa047440.97656495
67Hepatitis B_Homo sapiens_hsa051610.97014915
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94552629
69Melanogenesis_Homo sapiens_hsa049160.92624173
70Choline metabolism in cancer_Homo sapiens_hsa052310.89024895
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88996984
72Prolactin signaling pathway_Homo sapiens_hsa049170.88906787
73VEGF signaling pathway_Homo sapiens_hsa043700.88226024
74TNF signaling pathway_Homo sapiens_hsa046680.85924185
75Phagosome_Homo sapiens_hsa041450.85859531
76Collecting duct acid secretion_Homo sapiens_hsa049660.85328827
77MAPK signaling pathway_Homo sapiens_hsa040100.84808153
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82696649
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.82531513
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.81814760
81Oocyte meiosis_Homo sapiens_hsa041140.78561215
82Rheumatoid arthritis_Homo sapiens_hsa053230.78537364
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.78176834
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.78055861
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76676538
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72961879
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72664112
88Legionellosis_Homo sapiens_hsa051340.71525453
89B cell receptor signaling pathway_Homo sapiens_hsa046620.69977049
90Non-small cell lung cancer_Homo sapiens_hsa052230.68848110
91Dilated cardiomyopathy_Homo sapiens_hsa054140.68043008
92Chemokine signaling pathway_Homo sapiens_hsa040620.67634692
93Pancreatic secretion_Homo sapiens_hsa049720.67319889
94T cell receptor signaling pathway_Homo sapiens_hsa046600.66969500
95Chronic myeloid leukemia_Homo sapiens_hsa052200.66721020
96Circadian rhythm_Homo sapiens_hsa047100.65932791
97African trypanosomiasis_Homo sapiens_hsa051430.65621638
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65471850
99Dorso-ventral axis formation_Homo sapiens_hsa043200.64222813
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.63554786
101Ras signaling pathway_Homo sapiens_hsa040140.63246541
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63202156
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62904174
104Colorectal cancer_Homo sapiens_hsa052100.62828955
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61615463
106FoxO signaling pathway_Homo sapiens_hsa040680.61250309
107Rap1 signaling pathway_Homo sapiens_hsa040150.60234347
108Hepatitis C_Homo sapiens_hsa051600.59445104
109Endometrial cancer_Homo sapiens_hsa052130.59361318
110Wnt signaling pathway_Homo sapiens_hsa043100.58115545
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56669530
112Regulation of autophagy_Homo sapiens_hsa041400.56388796
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55772737
114Pertussis_Homo sapiens_hsa051330.55166049
115Platelet activation_Homo sapiens_hsa046110.54376440
116Cardiac muscle contraction_Homo sapiens_hsa042600.53164680
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52975706
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49924248
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49642507
120Inositol phosphate metabolism_Homo sapiens_hsa005620.48927789
121mTOR signaling pathway_Homo sapiens_hsa041500.47793195
122Osteoclast differentiation_Homo sapiens_hsa043800.46795996
123Alcoholism_Homo sapiens_hsa050340.45967897
124Thyroid hormone synthesis_Homo sapiens_hsa049180.45704538
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43706716
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43397925
127Glucagon signaling pathway_Homo sapiens_hsa049220.42997048
128Type I diabetes mellitus_Homo sapiens_hsa049400.42521569
129Vibrio cholerae infection_Homo sapiens_hsa051100.42285441
130Renal cell carcinoma_Homo sapiens_hsa052110.39526837
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38588895
132Salmonella infection_Homo sapiens_hsa051320.37160284
133Tuberculosis_Homo sapiens_hsa051520.37074758
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36524353
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36285993
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35258806
137Endocytosis_Homo sapiens_hsa041440.34358413
138Pancreatic cancer_Homo sapiens_hsa052120.31832212

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