CELSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.49883293
2cilium movement (GO:0003341)8.38475987
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.06978046
4motile cilium assembly (GO:0044458)7.99899476
5epithelial cilium movement (GO:0003351)6.71767600
6hemidesmosome assembly (GO:0031581)6.43629037
7left/right pattern formation (GO:0060972)5.46018380
8epithelial cell differentiation involved in prostate gland development (GO:0060742)5.13191742
9surfactant homeostasis (GO:0043129)4.65182659
10primary alcohol catabolic process (GO:0034310)4.60522420
11axoneme assembly (GO:0035082)4.48280283
12desmosome organization (GO:0002934)4.46905041
13* planar cell polarity pathway involved in neural tube closure (GO:0090179)4.45882577
14* lateral sprouting from an epithelium (GO:0060601)4.36028412
15embryonic retina morphogenesis in camera-type eye (GO:0060059)4.28398501
16vitamin transmembrane transport (GO:0035461)4.26616150
17regulation of somitogenesis (GO:0014807)4.25936969
18* dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.20364724
19* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.19615940
20ventricular system development (GO:0021591)4.15409051
21multicellular organismal water homeostasis (GO:0050891)4.14536254
22ear development (GO:0043583)4.10676996
23coronary vasculature morphogenesis (GO:0060977)4.02673681
24semaphorin-plexin signaling pathway (GO:0071526)3.96744725
25bundle of His cell to Purkinje myocyte communication (GO:0086069)3.88599459
26glomerular epithelial cell development (GO:0072310)3.84385042
27chemical homeostasis within a tissue (GO:0048875)3.81615315
28epithelial cell-cell adhesion (GO:0090136)3.80512095
29face development (GO:0060324)3.79059296
30regulation of endothelial cell chemotaxis (GO:2001026)3.76715715
31cell surface receptor signaling pathway involved in heart development (GO:0061311)3.60631983
32Notch signaling involved in heart development (GO:0061314)3.59525180
33branching involved in salivary gland morphogenesis (GO:0060445)3.55493829
34positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.51650487
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.49683055
36regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.49614831
37regulation of cilium movement (GO:0003352)3.44488475
38regulation of hippo signaling (GO:0035330)3.44330377
39apoptotic process involved in morphogenesis (GO:0060561)3.40268776
40diterpenoid biosynthetic process (GO:0016102)3.39354718
41left/right axis specification (GO:0070986)3.38872551
42collecting duct development (GO:0072044)3.34790293
43atrioventricular valve morphogenesis (GO:0003181)3.34739958
44thymic T cell selection (GO:0045061)3.34635296
45microtubule bundle formation (GO:0001578)3.31298464
46water homeostasis (GO:0030104)3.29551054
47lung-associated mesenchyme development (GO:0060484)3.28031073
48endothelial cell chemotaxis (GO:0035767)3.27790671
49somatic stem cell division (GO:0048103)3.26813828
50pyrimidine-containing compound transmembrane transport (GO:0072531)3.26700122
51regulation of cardioblast proliferation (GO:0003264)3.24334062
52regulation of secondary heart field cardioblast proliferation (GO:0003266)3.24334062
53cell-substrate junction assembly (GO:0007044)3.23932692
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.22624679
55tongue development (GO:0043586)3.21792799
56negative regulation of chondrocyte differentiation (GO:0032331)3.18391495
57epithelial cell fate commitment (GO:0072148)3.16196998
58epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.15831961
59ethanol metabolic process (GO:0006067)3.13872301
60regulation of water loss via skin (GO:0033561)3.12995216
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.12181367
62lens fiber cell development (GO:0070307)3.10317943
63regulation of protein heterodimerization activity (GO:0043497)3.09849807
64cochlea morphogenesis (GO:0090103)3.09785230
65endocardial cushion morphogenesis (GO:0003203)3.09275856
66keratinocyte proliferation (GO:0043616)3.07680463
67embryonic camera-type eye development (GO:0031076)3.06025522
68radial glial cell differentiation (GO:0060019)3.05882336
69hypotonic response (GO:0006971)3.04379642
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.03221886
71dorsal/ventral axis specification (GO:0009950)3.02508763
72camera-type eye morphogenesis (GO:0048593)3.02451292
73regulation of interleukin-5 production (GO:0032674)3.02257148
74renal system development (GO:0072001)3.01972472
75heart valve formation (GO:0003188)3.01839669
76positive regulation of smoothened signaling pathway (GO:0045880)3.01071673
77negative regulation of keratinocyte proliferation (GO:0010839)2.98283719
78positive thymic T cell selection (GO:0045059)2.96837132
79lung epithelium development (GO:0060428)2.95028886
80mesenchyme morphogenesis (GO:0072132)2.94675409
81neuronal stem cell maintenance (GO:0097150)2.94131586
82negative regulation of glial cell proliferation (GO:0060253)2.93765852
83paraxial mesoderm development (GO:0048339)2.93617576
84establishment of apical/basal cell polarity (GO:0035089)2.92750608
85regulation of interleukin-13 production (GO:0032656)2.92220501
86hippo signaling (GO:0035329)2.88203445
87negative regulation of cell fate specification (GO:0009996)2.88108326
88intraciliary transport (GO:0042073)2.86816398
89midgut development (GO:0007494)2.82046285
90regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.81096479
91positive regulation of neuroblast proliferation (GO:0002052)2.80254718
92negative T cell selection (GO:0043383)2.80119685
93cardiac muscle cell proliferation (GO:0060038)2.79933912
94* non-canonical Wnt signaling pathway (GO:0035567)2.79754154
95establishment of skin barrier (GO:0061436)2.79433669
96negative thymic T cell selection (GO:0045060)2.77667209
97cilium organization (GO:0044782)2.76980952
98negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76600617
99adherens junction assembly (GO:0034333)2.76333528
100gap junction assembly (GO:0016264)2.75978836
101glial cell proliferation (GO:0014009)2.75183579
102embryonic foregut morphogenesis (GO:0048617)2.74483138
103peptidyl-tyrosine autophosphorylation (GO:0038083)2.73694010
104positive regulation of neural precursor cell proliferation (GO:2000179)2.71413301
105cilium assembly (GO:0042384)2.71339115
106* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70511399
107ectoderm development (GO:0007398)2.66905880
108regulation of heart morphogenesis (GO:2000826)2.64695737
109COPI coating of Golgi vesicle (GO:0048205)2.64664263
110Golgi transport vesicle coating (GO:0048200)2.64664263
111morphogenesis of an epithelial sheet (GO:0002011)2.64456335
112convergent extension (GO:0060026)2.64440609
113negative regulation of RNA splicing (GO:0033119)2.64409807
114mesenchymal cell proliferation (GO:0010463)2.64378397
115regulation of cardioblast differentiation (GO:0051890)2.63814119
116* establishment of tissue polarity (GO:0007164)2.63598930
117* establishment of planar polarity (GO:0001736)2.63598930
118* regulation of establishment of planar polarity (GO:0090175)2.62961621
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62911265
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62911265
121regulation of transforming growth factor beta2 production (GO:0032909)2.61683570
122striated muscle cell proliferation (GO:0014855)2.61114680
123hair cycle (GO:0042633)2.60899881
124molting cycle (GO:0042303)2.60899881
125T cell selection (GO:0045058)2.60083780
126antigen processing and presentation of endogenous antigen (GO:0019883)2.58962912
127* epidermis development (GO:0008544)2.57511499
128intestinal epithelial cell development (GO:0060576)2.55000897
129positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54750994
130regulation of cholesterol homeostasis (GO:2000188)2.53595992
131positive regulation of histone deacetylation (GO:0031065)2.53183475
132cardiac right ventricle morphogenesis (GO:0003215)2.52708190
133negative regulation of mRNA processing (GO:0050686)2.52439933
134microtubule-based movement (GO:0007018)2.52311478
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.51203287
136focal adhesion assembly (GO:0048041)2.51157295
137cell-substrate adherens junction assembly (GO:0007045)2.51157295
138establishment or maintenance of bipolar cell polarity (GO:0061245)2.51044673
139establishment or maintenance of apical/basal cell polarity (GO:0035088)2.51044673
140mammary gland epithelial cell differentiation (GO:0060644)2.50929406
141regulation of sister chromatid cohesion (GO:0007063)2.50178070
142polarized epithelial cell differentiation (GO:0030859)2.50025375
143trophectodermal cell differentiation (GO:0001829)2.49537140
144* asymmetric protein localization (GO:0008105)2.49043218
145body morphogenesis (GO:0010171)2.48794553
146embryonic body morphogenesis (GO:0010172)2.48023781
147canonical Wnt signaling pathway (GO:0060070)2.47838127
148notochord development (GO:0030903)2.47504958
149regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.47400230
150establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47378595
151DNA unwinding involved in DNA replication (GO:0006268)2.47310139
152glucocorticoid receptor signaling pathway (GO:0042921)2.47110272
153axon extension involved in axon guidance (GO:0048846)2.46808165
154neuron projection extension involved in neuron projection guidance (GO:1902284)2.46808165
155retinoic acid metabolic process (GO:0042573)2.46650910
156keratinocyte differentiation (GO:0030216)2.44455540
157establishment of monopolar cell polarity (GO:0061162)2.43546459
158establishment or maintenance of monopolar cell polarity (GO:0061339)2.43546459
159regulation of gamma-delta T cell differentiation (GO:0045586)2.42578535
160tight junction assembly (GO:0070830)2.40229755
161cell-cell junction assembly (GO:0007043)2.39986363
162skin morphogenesis (GO:0043589)2.38462813
163negative regulation of T cell differentiation in thymus (GO:0033085)2.35191269
164* hair follicle development (GO:0001942)2.34162589
165activation of Rac GTPase activity (GO:0032863)2.30916462
166O-glycan processing (GO:0016266)2.30181423
167negative regulation of cartilage development (GO:0061037)2.30092481
168positive regulation of keratinocyte differentiation (GO:0045618)2.29428849
169cell projection assembly (GO:0030031)2.28081851
170cell adhesion mediated by integrin (GO:0033627)2.27463893
171diaphragm development (GO:0060539)2.27050819
172axonemal dynein complex assembly (GO:0070286)11.5000700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.72043141
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45330897
3E2F7_22180533_ChIP-Seq_HELA_Human3.38937441
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03228256
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.82573320
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.82172409
7MYC_22102868_ChIP-Seq_BL_Human2.78872850
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77080682
9ZNF263_19887448_ChIP-Seq_K562_Human2.35804666
10TCF7_22412390_ChIP-Seq_EML_Mouse2.01920967
11TP63_17297297_ChIP-ChIP_HaCaT_Human10.0952716
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.97236657
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95015168
14* AHR_22903824_ChIP-Seq_MCF-7_Human1.94689039
15* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.93621104
16CLOCK_20551151_ChIP-Seq_293T_Human1.91794854
17KDM2B_26808549_Chip-Seq_DND41_Human1.89805310
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88489247
19* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88406742
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.87937467
21RACK7_27058665_Chip-Seq_MCF-7_Human1.79449574
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.77735372
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77670052
24VDR_21846776_ChIP-Seq_THP-1_Human1.76089668
25* KLF5_25053715_ChIP-Seq_YYC3_Human1.72459238
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72085617
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.71701048
28SMC4_20622854_ChIP-Seq_HELA_Human1.71611287
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.71263661
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70727985
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69072438
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65245582
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65137473
34* ELK3_25401928_ChIP-Seq_HUVEC_Human1.63982704
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62772776
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.61342164
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60681801
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60159981
39* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52573968
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50146139
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47239281
42GATA6_25053715_ChIP-Seq_YYC3_Human1.44810108
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44761455
44* LXR_22292898_ChIP-Seq_THP-1_Human1.44194455
45* ARNT_22903824_ChIP-Seq_MCF-7_Human1.43574513
46* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43047573
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41108092
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40558072
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.38830803
50AR_21909140_ChIP-Seq_LNCAP_Human1.37600817
51* DROSHA_22980978_ChIP-Seq_HELA_Human1.37221722
52* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36987988
53KDM2B_26808549_Chip-Seq_K562_Human1.36127716
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35198854
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34772322
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33289927
57* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30838991
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29451858
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29382541
60ATF3_27146783_Chip-Seq_COLON_Human1.28596978
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.28155952
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27894831
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.27647228
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27379506
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27379506
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26336514
67* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25228233
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24188725
69TP53_22127205_ChIP-Seq_IMR90_Human1.24084586
70UTX_26944678_Chip-Seq_JUKART_Human1.22662108
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.22580651
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21079232
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.20472272
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20416976
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19916738
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18784637
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18177802
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.17884330
79* CREB1_26743006_Chip-Seq_LNCaP_Human1.17461610
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14271008
81SOX2_20726797_ChIP-Seq_SW620_Human1.13928046
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13821795
83MAF_26560356_Chip-Seq_TH1_Human1.13126903
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12720736
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12715703
86P68_20966046_ChIP-Seq_HELA_Human1.12396565
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11768885
88* CTCF_27219007_Chip-Seq_Bcells_Human1.11578972
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10577705
90CHD1_26751641_Chip-Seq_LNCaP_Human1.10502577
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10320352
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.09163746
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07933049
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07850456
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.07099593
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.06848364
97* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06289458
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05853475
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04707465
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02766606
101CDX2_20551321_ChIP-Seq_CACO-2_Human1.02569481
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00911965
103TP53_23651856_ChIP-Seq_MEFs_Mouse1.00296809
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98935936
105* TBX20_22080862_ChIP-Seq_HEART_Mouse0.98744853
106* TBX20_22328084_ChIP-Seq_HEART_Mouse0.98744853
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97963263
108NCOR1_26117541_ChIP-Seq_K562_Human0.96404531
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96249188
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96145953
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95872204
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94868017
113VDR_24763502_ChIP-Seq_THP-1_Human0.94761209
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94255702
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93382357
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93159265
117* TP63_23658742_ChIP-Seq_EP156T_Human0.92960915
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92338967
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92055389
120GATA4_25053715_ChIP-Seq_YYC3_Human0.92039007
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91794809
122SA1_27219007_Chip-Seq_ERYTHROID_Human0.91670857
123POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91669240
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89742764
125TP63_22573176_ChIP-Seq_HFKS_Human0.89671010
126TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88734931
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.88620112
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88519892
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87296135
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85023916
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83359289
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83194075
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83047957
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83021261
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79089364
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76689764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.01736688
2MP0002254_reproductive_system_inflammat3.79068279
3MP0000566_synostosis3.44740519
4MP0010030_abnormal_orbit_morphology3.13765958
5MP0003705_abnormal_hypodermis_morpholog3.04631098
6MP0000537_abnormal_urethra_morphology2.98330263
7MP0009053_abnormal_anal_canal2.73310015
8MP0000579_abnormal_nail_morphology2.63363948
9MP0002796_impaired_skin_barrier2.49366737
10MP0002653_abnormal_ependyma_morphology2.41532046
11MP0002234_abnormal_pharynx_morphology2.39850132
12MP0002098_abnormal_vibrissa_morphology2.36498824
13MP0008789_abnormal_olfactory_epithelium2.29390561
14* MP0010678_abnormal_skin_adnexa2.26124055
15* MP0000383_abnormal_hair_follicle2.23547287
16MP0005076_abnormal_cell_differentiation2.19820246
17MP0009780_abnormal_chondrocyte_physiolo2.17564817
18MP0001346_abnormal_lacrimal_gland2.14129952
19MP0005409_darkened_coat_color2.13192817
20MP0001849_ear_inflammation2.07037848
21MP0005623_abnormal_meninges_morphology1.96144304
22MP0003941_abnormal_skin_development1.84537200
23MP0004782_abnormal_surfactant_physiolog1.82456827
24MP0004381_abnormal_hair_follicle1.81527509
25MP0002249_abnormal_larynx_morphology1.76931747
26MP0010352_gastrointestinal_tract_polyps1.75971796
27MP0000467_abnormal_esophagus_morphology1.74323206
28MP0005248_abnormal_Harderian_gland1.70876412
29MP0001216_abnormal_epidermal_layer1.65842754
30MP0000377_abnormal_hair_follicle1.65798472
31MP0004272_abnormal_basement_membrane1.65794157
32MP0005499_abnormal_olfactory_system1.62793541
33MP0005394_taste/olfaction_phenotype1.62793541
34MP0008875_abnormal_xenobiotic_pharmacok1.61547418
35MP0000428_abnormal_craniofacial_morphol1.61331818
36MP0000647_abnormal_sebaceous_gland1.58399867
37MP0003453_abnormal_keratinocyte_physiol1.57979203
38MP0005501_abnormal_skin_physiology1.54979180
39MP0000762_abnormal_tongue_morphology1.51156665
40MP0004133_heterotaxia1.50262620
41MP0002060_abnormal_skin_morphology1.49225831
42MP0003763_abnormal_thymus_physiology1.47511458
43MP0002282_abnormal_trachea_morphology1.44475307
44MP0003115_abnormal_respiratory_system1.38452173
45MP0000049_abnormal_middle_ear1.38248717
46MP0002233_abnormal_nose_morphology1.37670707
47MP0003942_abnormal_urinary_system1.35519031
48MP0002092_abnormal_eye_morphology1.31572259
49MP0002877_abnormal_melanocyte_morpholog1.31039675
50MP0005257_abnormal_intraocular_pressure1.30815817
51MP0004043_abnormal_pH_regulation1.28613237
52MP0000613_abnormal_salivary_gland1.25489606
53MP0003136_yellow_coat_color1.23406778
54MP0002697_abnormal_eye_size1.21795058
55MP0003091_abnormal_cell_migration1.21078376
56MP0002896_abnormal_bone_mineralization1.20709916
57MP0002932_abnormal_joint_morphology1.17787558
58MP0006292_abnormal_olfactory_placode1.13565695
59MP0004858_abnormal_nervous_system1.11655582
60MP0009278_abnormal_bone_marrow1.11438460
61MP0003566_abnormal_cell_adhesion1.10666495
62MP0000678_abnormal_parathyroid_gland1.10159654
63MP0003878_abnormal_ear_physiology1.10113304
64MP0005377_hearing/vestibular/ear_phenot1.10113304
65MP0003755_abnormal_palate_morphology1.09495536
66MP0004233_abnormal_muscle_weight1.08210020
67MP0005275_abnormal_skin_tensile1.08079355
68MP0003937_abnormal_limbs/digits/tail_de1.05084264
69MP0005083_abnormal_biliary_tract1.05014224
70MP0000627_abnormal_mammary_gland1.03595869
71MP0001293_anophthalmia1.01490899
72MP0003935_abnormal_craniofacial_develop0.99899705
73MP0008961_abnormal_basal_metabolism0.98521779
74MP0003300_gastrointestinal_ulcer0.98222686
75MP0001666_abnormal_nutrient_absorption0.97033848
76MP0001286_abnormal_eye_development0.95874305
77* MP0001340_abnormal_eyelid_morphology0.95108726
78MP0003119_abnormal_digestive_system0.93921189
79MP0003938_abnormal_ear_development0.93444827
80MP0000432_abnormal_head_morphology0.92739829
81MP0005220_abnormal_exocrine_pancreas0.92563022
82MP0009384_cardiac_valve_regurgitation0.92297499
83MP0003567_abnormal_fetal_cardiomyocyte0.91641423
84MP0005365_abnormal_bile_salt0.91518207
85MP0002084_abnormal_developmental_patter0.91456959
86* MP0010771_integument_phenotype0.90767462
87MP0000427_abnormal_hair_cycle0.90292674
88MP0002168_other_aberrant_phenotype0.90174067
89MP0004197_abnormal_fetal_growth/weight/0.89724849
90MP0000534_abnormal_ureter_morphology0.88971886
91MP0002132_abnormal_respiratory_system0.88101085
92MP0004947_skin_inflammation0.88008039
93MP0002009_preneoplasia0.86830416
94MP0005058_abnormal_lysosome_morphology0.86460922
95MP0001958_emphysema0.86277805
96MP0004019_abnormal_vitamin_homeostasis0.85841383
97* MP0002116_abnormal_craniofacial_bone0.85040441
98MP0005187_abnormal_penis_morphology0.84963350
99MP0010368_abnormal_lymphatic_system0.84887962
100MP0002089_abnormal_postnatal_growth/wei0.84623209
101MP0004264_abnormal_extraembryonic_tissu0.84466962
102MP0006138_congestive_heart_failure0.84285913
103* MP0002085_abnormal_embryonic_tissue0.82175991
104MP0003283_abnormal_digestive_organ0.81321105
105MP0002277_abnormal_respiratory_mucosa0.80928108
106MP0006054_spinal_hemorrhage0.80257811
107MP0001873_stomach_inflammation0.79095419
108MP0001348_abnormal_lacrimal_gland0.78761646
109* MP0002111_abnormal_tail_morphology0.78364401
110MP0000733_abnormal_muscle_development0.78110878
111MP0009931_abnormal_skin_appearance0.77710415
112MP0005023_abnormal_wound_healing0.76404812
113MP0005508_abnormal_skeleton_morphology0.75207122
114MP0005085_abnormal_gallbladder_physiolo0.74532984
115MP0001984_abnormal_olfaction0.73522412
116MP0001299_abnormal_eye_distance/0.73302459
117MP0000685_abnormal_immune_system0.73281918
118MP0000858_altered_metastatic_potential0.72486547
119MP0004185_abnormal_adipocyte_glucose0.68309809
120MP0000462_abnormal_digestive_system0.67162722
121MP0001879_abnormal_lymphatic_vessel0.66019495
122MP0001784_abnormal_fluid_regulation0.65886768
123MP0005360_urolithiasis0.65751466
124MP0001672_abnormal_embryogenesis/_devel0.65616270
125MP0005380_embryogenesis_phenotype0.65616270
126MP0000703_abnormal_thymus_morphology0.65426315
127MP0001851_eye_inflammation0.65158575
128MP0003385_abnormal_body_wall0.64839713
129MP0001765_abnormal_ion_homeostasis0.62959015
130MP0000767_abnormal_smooth_muscle0.62584789
131MP0001730_embryonic_growth_arrest0.62505518
132MP0002088_abnormal_embryonic_growth/wei0.62256517
133MP0003634_abnormal_glial_cell0.61722765
134MP0002925_abnormal_cardiovascular_devel0.60364070
135MP0003191_abnormal_cellular_cholesterol0.59674200
136MP0005197_abnormal_uvea_morphology0.56316146

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.85368508
2Abnormal respiratory motile cilium morphology (HP:0005938)7.56686450
3Abnormal respiratory epithelium morphology (HP:0012253)7.56686450
4Abnormal respiratory motile cilium physiology (HP:0012261)7.39566689
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.25370436
6Absent/shortened dynein arms (HP:0200106)7.25370436
7Abnormal ciliary motility (HP:0012262)7.14727616
8Rhinitis (HP:0012384)6.72300631
9Chronic bronchitis (HP:0004469)5.76434940
10Milia (HP:0001056)5.09385890
11Bronchiectasis (HP:0002110)4.86916840
12Nasal polyposis (HP:0100582)4.77763705
13Fragile nails (HP:0001808)4.48828956
14Onycholysis (HP:0001806)4.15990623
15Abnormality of the nasal mucosa (HP:0000433)3.95936702
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.94565579
17Short 4th metacarpal (HP:0010044)3.94565579
18Right ventricular cardiomyopathy (HP:0011663)3.44526104
19Woolly hair (HP:0002224)3.38307140
20Plantar hyperkeratosis (HP:0007556)3.37681014
21Esophageal atresia (HP:0002032)3.24200018
22Recurrent otitis media (HP:0000403)3.15004673
23Abnormality of the 4th metacarpal (HP:0010012)3.12000059
24Atrophic scars (HP:0001075)3.04275939
25Lip pit (HP:0100267)2.88023386
26Bronchitis (HP:0012387)2.85638044
27Infertility (HP:0000789)2.85252020
28Shallow orbits (HP:0000586)2.81925277
29Male infertility (HP:0003251)2.79004233
30Ureteral stenosis (HP:0000071)2.75262007
31Pili torti (HP:0003777)2.68661740
32Down-sloping shoulders (HP:0200021)2.67224255
33Recurrent sinusitis (HP:0011108)2.63715385
34Aplasia cutis congenita (HP:0001057)2.62049813
35Pseudobulbar signs (HP:0002200)2.61240709
36Hyperacusis (HP:0010780)2.60779200
37Atelectasis (HP:0100750)2.51438801
38Nail dystrophy (HP:0008404)2.50925236
39Hyperactive renin-angiotensin system (HP:0000841)2.49870640
40Hypoplastic labia majora (HP:0000059)2.45218071
41Ureteral obstruction (HP:0006000)2.44671133
42Selective tooth agenesis (HP:0001592)2.43347390
43Coronal craniosynostosis (HP:0004440)2.43207581
44Ridged nail (HP:0001807)2.42070699
45Oligodactyly (HP:0012165)2.40365804
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39646475
47Broad face (HP:0000283)2.39129610
48Thick nail (HP:0001805)2.37139093
49Absent frontal sinuses (HP:0002688)2.37070355
50Abnormality of the gastric mucosa (HP:0004295)2.35321662
51Abnormality of the fingertips (HP:0001211)2.34768885
52Hypotrichosis (HP:0001006)2.34760963
53Germ cell neoplasia (HP:0100728)2.34266321
54Advanced eruption of teeth (HP:0006288)2.34051031
55Occipital encephalocele (HP:0002085)2.33757794
56Short nail (HP:0001799)2.31595055
57Flat acetabular roof (HP:0003180)2.30338840
58Natal tooth (HP:0000695)2.29027801
59Aplasia/Hypoplasia of the sternum (HP:0006714)2.27173899
60Skull defect (HP:0001362)2.26016471
61Abnormality of permanent molar morphology (HP:0011071)2.25935371
62Abnormality of the dental root (HP:0006486)2.25935371
63Taurodontia (HP:0000679)2.25935371
64Abnormality of the labia majora (HP:0012881)2.18629316
65Abnormality of the antihelix (HP:0009738)2.17971611
66Palmoplantar hyperkeratosis (HP:0000972)2.17124127
67Spastic diplegia (HP:0001264)2.16629248
68Chronic sinusitis (HP:0011109)2.13081738
69Rectal prolapse (HP:0002035)2.12149927
70Obstructive sleep apnea (HP:0002870)2.11861324
71Increased IgE level (HP:0003212)2.11311848
72Popliteal pterygium (HP:0009756)2.10493700
73Abnormality of the diencephalon (HP:0010662)2.06949048
74Facial hemangioma (HP:0000329)2.06804499
75Renal duplication (HP:0000075)2.06783778
76Abnormality of molar morphology (HP:0011070)2.06052196
77Abnormality of molar (HP:0011077)2.06052196
78Abnormal hair laboratory examination (HP:0003328)2.05356158
79Palmar hyperkeratosis (HP:0010765)2.05342593
80Trigonocephaly (HP:0000243)2.03821594
81Overriding aorta (HP:0002623)2.03343492
82Elfin facies (HP:0004428)2.02320924
83Skin tags (HP:0010609)2.01255790
84Renovascular hypertension (HP:0100817)1.99893016
85Esophageal varix (HP:0002040)1.99701586
86Broad hallux (HP:0010055)1.99263749
87Pterygium (HP:0001059)1.99009981
88Abnormality of the dental pulp (HP:0006479)1.98006750
89Bicornuate uterus (HP:0000813)1.97570018
90Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.95901534
91Hypoplasia of dental enamel (HP:0006297)1.95590073
92Alopecia of scalp (HP:0002293)1.93237877
93Abnormality of the aortic arch (HP:0012303)1.93216647
94Midline defect of the nose (HP:0004122)1.92855687
95Abnormal number of incisors (HP:0011064)1.91782528
96Vertebral arch anomaly (HP:0008438)1.91187092
97Increased nuchal translucency (HP:0010880)1.90888101
98Bell-shaped thorax (HP:0001591)1.89623158
99Cystic liver disease (HP:0006706)1.88177974
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.87493851
101Anonychia (HP:0001798)1.87274914
102Neonatal death (HP:0003811)1.86967672
103Renal dysplasia (HP:0000110)1.86813303
104Preauricular skin tag (HP:0000384)1.86115387
105Broad toe (HP:0001837)1.85921138
106Subacute progressive viral hepatitis (HP:0006572)1.85163949
107Interstitial pulmonary disease (HP:0006530)1.84273761
108Short phalanx of the thumb (HP:0009660)1.83651854
109Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82891717
110Cervical subluxation (HP:0003308)1.81908115
111Gastrointestinal atresia (HP:0002589)1.81386899
112Abnormality of the pubic bones (HP:0003172)1.81282224
113Choanal stenosis (HP:0000452)1.80432769
114Ankyloglossia (HP:0010296)1.78960957
115Arnold-Chiari malformation (HP:0002308)1.78533397
116Abnormal blistering of the skin (HP:0008066)1.77290449
117Fragile skin (HP:0001030)1.76727714
118Aplasia involving bones of the extremities (HP:0009825)1.76336640
119Aplasia involving bones of the upper limbs (HP:0009823)1.76336640
120Aplasia of the phalanges of the hand (HP:0009802)1.76336640
121Partial duplication of thumb phalanx (HP:0009944)1.75246020
122Arterial tortuosity (HP:0005116)1.74884924
123Distal lower limb muscle weakness (HP:0009053)1.73674010
124Rib fusion (HP:0000902)1.73343531
125Abnormality of the salivary glands (HP:0010286)1.72862127
126Abnormality of the metopic suture (HP:0005556)1.72723052
127Blepharitis (HP:0000498)1.71995592
128Broad thumb (HP:0011304)1.71769406
129Laryngomalacia (HP:0001601)1.71502296
130Vertebral hypoplasia (HP:0008417)1.71443508
131Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71443508
132Ventricular tachycardia (HP:0004756)1.69937351
133Sparse scalp hair (HP:0002209)1.69551797
134Morphological abnormality of the middle ear (HP:0008609)1.68690560
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.66662632
136Abnormality of nail color (HP:0100643)1.66398721
137Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65978081
138Atresia of the external auditory canal (HP:0000413)1.65831422
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65300050
140Anophthalmia (HP:0000528)1.64972183
141Bronchomalacia (HP:0002780)1.64704700
142Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.63933278
143Short 1st metacarpal (HP:0010034)1.63933278
144Hemivertebrae (HP:0002937)1.62503027
145Ulnar bowing (HP:0003031)1.62382808
146Abnormality of oral frenula (HP:0000190)1.62122623
147Absent eyelashes (HP:0000561)1.60789539
148Abnormality of the distal phalanges of the toes (HP:0010182)1.59655259
149Gastrointestinal carcinoma (HP:0002672)1.59343638
150Malignant gastrointestinal tract tumors (HP:0006749)1.59343638
151Humeroradial synostosis (HP:0003041)1.59294335
152Synostosis involving the elbow (HP:0003938)1.59294335
153Nuclear cataract (HP:0100018)1.59019473
154Tubulointerstitial nephritis (HP:0001970)1.58925481
155Broad distal phalanx of finger (HP:0009836)1.57668210
156Abnormality of dentin (HP:0010299)1.55137530
157Abnormality of the frontal sinuses (HP:0002687)1.49018598
158Abnormal vertebral ossification (HP:0100569)1.48905579
159Tubular atrophy (HP:0000092)1.48845160
160Bifid scrotum (HP:0000048)1.46759732
161Spinal cord compression (HP:0002176)1.45959752
162Vascular tortuosity (HP:0004948)1.45648629
163Distal upper limb amyotrophy (HP:0007149)1.43631084
164Upper limb amyotrophy (HP:0009129)1.43631084
165Hypodontia (HP:0000668)1.42122281
166Oligodontia (HP:0000677)1.41762940
167True hermaphroditism (HP:0010459)1.41604005
168Chronic otitis media (HP:0000389)1.41296784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.75097705
2EPHB24.25427958
3MAP3K103.65690339
4PKN23.08304588
5TRIB33.06975297
6RPS6KB22.57068954
7SIK12.55349195
8LATS12.53101475
9SMG12.48950601
10MET2.46863429
11PTK62.22820931
12FGFR42.19946158
13CDK122.17009053
14FGFR22.12629008
15MAP3K22.08909795
16EPHA22.00776645
17LRRK21.72836801
18FGFR31.72000301
19STK101.69761032
20LATS21.59440570
21NTRK11.59173019
22CDK61.50264305
23ERBB21.48228534
24NEK21.34501851
25LMTK21.33745212
26FGFR11.31030867
27MAPKAPK31.27866864
28NME11.26273506
29MTOR1.24277359
30MST41.19512021
31FER1.17614748
32RIPK11.16317917
33TTN1.16105585
34PAK41.15348154
35PNCK1.13155968
36ICK1.12589793
37EPHB11.12237065
38PTK21.11800861
39NME21.11722931
40PDGFRA1.08893265
41MAP4K11.07319111
42EPHA31.05739731
43NEK60.99038463
44DDR20.97020807
45MAP3K70.96605104
46CDC70.96384358
47TYRO30.95810901
48MKNK10.93726353
49CDK40.93268247
50TESK10.92451492
51IRAK30.92201488
52HIPK20.90833367
53ERN10.90258561
54MAP3K30.87941058
55MST1R0.87788659
56RPS6KA40.87390480
57CHUK0.86978216
58MAP2K20.86264937
59MAP3K80.83505797
60MAPK150.81295964
61DMPK0.79777344
62MARK20.79172826
63TRPM70.77666754
64PASK0.77107199
65MAP3K130.77101945
66NLK0.77058081
67DYRK1B0.76605459
68PDGFRB0.76443409
69RPS6KA10.74694981
70CAMK1G0.74286414
71TGFBR10.74262885
72TYK20.74130658
73ITK0.72493567
74DYRK30.70670183
75STK30.70275745
76STK390.70077780
77GRK60.69286445
78MKNK20.68625385
79WNK40.67359986
80PRKCI0.66254761
81ALK0.65477644
82PAK20.65107140
83TAOK10.64211688
84TSSK60.59820781
85RPS6KC10.59800368
86RPS6KL10.59800368
87STK38L0.59488525
88STK380.58844968
89MUSK0.58801603
90ZAP700.58356597
91ILK0.57970847
92JAK30.57481254
93GSK3A0.56889320
94AURKB0.56450711
95STK40.56037804
96ERBB30.55854370
97BRD40.55186181
98MAP3K60.54915690
99BCR0.54394294
100SIK20.52643946
101RPS6KA60.52546789
102ARAF0.52149403
103CDK70.51854763
104PRKD20.50546557
105BMX0.50409831
106CSNK1A1L0.48441235
107AKT20.48105990
108RPS6KA20.48017961
109CDC42BPA0.47479249
110PRKD30.47455510
111NEK10.47134651
112IKBKE0.45459048
113RET0.45416023
114CDK90.44602474
115FLT30.44541823
116TBK10.43437822
117ROCK20.43222390
118MAPK110.43160252
119MAP3K90.42245938
120MAPKAPK20.41074314
121PIM20.40272773
122CAMK1D0.39364577
123ATR0.38358620
124CSNK1G10.38256762
125BCKDK0.37961401
126CSNK1D0.37611474
127STK240.36990763
128TTK0.34706011
129PDPK10.33446634
130CLK10.33200163
131BTK0.33165039
132ROCK10.30500414
133RPS6KB10.29749033
134CAMKK10.29677712
135NEK90.29530031
136CSK0.29362929
137MELK0.29233048
138CAMK2G0.25902241
139MAPK100.24252100
140AURKA0.22687738
141MAPK80.18850275
142PRKD10.18570980

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.91282806
2Notch signaling pathway_Homo sapiens_hsa043303.10277738
3Hedgehog signaling pathway_Homo sapiens_hsa043402.33766065
4Hippo signaling pathway_Homo sapiens_hsa043902.28498527
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.12985578
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.08558179
7Lysine degradation_Homo sapiens_hsa003102.06486394
8Small cell lung cancer_Homo sapiens_hsa052221.80964519
9Adherens junction_Homo sapiens_hsa045201.78180058
10MicroRNAs in cancer_Homo sapiens_hsa052061.71563557
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69979617
12Tyrosine metabolism_Homo sapiens_hsa003501.58579865
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55159982
14Sphingolipid metabolism_Homo sapiens_hsa006001.53887237
15Dorso-ventral axis formation_Homo sapiens_hsa043201.50949252
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45506461
17Chronic myeloid leukemia_Homo sapiens_hsa052201.41679537
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37886918
19Proteoglycans in cancer_Homo sapiens_hsa052051.37864744
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32806994
21Renal cell carcinoma_Homo sapiens_hsa052111.31038219
22ECM-receptor interaction_Homo sapiens_hsa045121.30737780
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28345528
24Thyroid cancer_Homo sapiens_hsa052161.27948555
25Viral myocarditis_Homo sapiens_hsa054161.27552444
26HTLV-I infection_Homo sapiens_hsa051661.27041068
27Wnt signaling pathway_Homo sapiens_hsa043101.25647451
28Arginine biosynthesis_Homo sapiens_hsa002201.25611747
29Endometrial cancer_Homo sapiens_hsa052131.23421454
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.23376534
31Fatty acid degradation_Homo sapiens_hsa000711.20298370
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19781770
33ErbB signaling pathway_Homo sapiens_hsa040121.19302382
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18910155
35Lysosome_Homo sapiens_hsa041421.18849008
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.17223126
37Bladder cancer_Homo sapiens_hsa052191.16225654
38Primary immunodeficiency_Homo sapiens_hsa053401.15263725
39Tight junction_Homo sapiens_hsa045301.15168583
40Dilated cardiomyopathy_Homo sapiens_hsa054141.14309116
41Other glycan degradation_Homo sapiens_hsa005111.14278686
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14017191
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13005492
44Choline metabolism in cancer_Homo sapiens_hsa052311.12078746
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10829052
46Insulin resistance_Homo sapiens_hsa049311.09703931
47Pathways in cancer_Homo sapiens_hsa052001.07680254
48Protein digestion and absorption_Homo sapiens_hsa049741.07452396
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07044940
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.04591735
51Melanogenesis_Homo sapiens_hsa049161.04319785
52Toxoplasmosis_Homo sapiens_hsa051451.04096228
53Chemical carcinogenesis_Homo sapiens_hsa052041.04013989
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02460765
55Fat digestion and absorption_Homo sapiens_hsa049750.99218741
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98982095
57Fructose and mannose metabolism_Homo sapiens_hsa000510.97938969
58TGF-beta signaling pathway_Homo sapiens_hsa043500.97470434
59Tryptophan metabolism_Homo sapiens_hsa003800.96947807
60Colorectal cancer_Homo sapiens_hsa052100.92298539
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91947737
62Histidine metabolism_Homo sapiens_hsa003400.91661816
63T cell receptor signaling pathway_Homo sapiens_hsa046600.90078996
64Focal adhesion_Homo sapiens_hsa045100.89730110
65Nitrogen metabolism_Homo sapiens_hsa009100.89085507
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.88396206
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87058822
68Axon guidance_Homo sapiens_hsa043600.86997902
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86708099
70Phenylalanine metabolism_Homo sapiens_hsa003600.83538672
71Selenocompound metabolism_Homo sapiens_hsa004500.82542492
72Estrogen signaling pathway_Homo sapiens_hsa049150.82178499
73Antigen processing and presentation_Homo sapiens_hsa046120.80955016
74Prostate cancer_Homo sapiens_hsa052150.79759322
75Acute myeloid leukemia_Homo sapiens_hsa052210.78784060
76Biosynthesis of amino acids_Homo sapiens_hsa012300.77845072
77Glutathione metabolism_Homo sapiens_hsa004800.76582650
78Pancreatic cancer_Homo sapiens_hsa052120.75629343
79Spliceosome_Homo sapiens_hsa030400.75136299
80mTOR signaling pathway_Homo sapiens_hsa041500.74997252
81mRNA surveillance pathway_Homo sapiens_hsa030150.73627592
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73100111
83Bile secretion_Homo sapiens_hsa049760.72476615
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72125988
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71877736
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71813579
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71403022
88PPAR signaling pathway_Homo sapiens_hsa033200.70664265
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70553394
90Prion diseases_Homo sapiens_hsa050200.70313772
91N-Glycan biosynthesis_Homo sapiens_hsa005100.66829303
92Amoebiasis_Homo sapiens_hsa051460.66491845
93Fatty acid metabolism_Homo sapiens_hsa012120.66402739
94Non-small cell lung cancer_Homo sapiens_hsa052230.65414880
95p53 signaling pathway_Homo sapiens_hsa041150.64644997
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64294669
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.64209774
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63660113
99Cell cycle_Homo sapiens_hsa041100.63268399
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63222291
101Fatty acid biosynthesis_Homo sapiens_hsa000610.62974445
102Prolactin signaling pathway_Homo sapiens_hsa049170.62672944
103Galactose metabolism_Homo sapiens_hsa000520.62563671
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61440513
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60308103
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.59590960
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59509692
108GnRH signaling pathway_Homo sapiens_hsa049120.59195092
109Viral carcinogenesis_Homo sapiens_hsa052030.58979109
110Endocytosis_Homo sapiens_hsa041440.58975378
111Retinol metabolism_Homo sapiens_hsa008300.58683370
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58329899
113Glioma_Homo sapiens_hsa052140.58232077
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57406286
115Herpes simplex infection_Homo sapiens_hsa051680.57209252
116One carbon pool by folate_Homo sapiens_hsa006700.56903779
117Pancreatic secretion_Homo sapiens_hsa049720.56708536
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56263028
119Ribosome_Homo sapiens_hsa030100.56202620
120Ovarian steroidogenesis_Homo sapiens_hsa049130.55204832
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.54820722
122Sulfur relay system_Homo sapiens_hsa041220.53825869
123Inositol phosphate metabolism_Homo sapiens_hsa005620.53551847
124ABC transporters_Homo sapiens_hsa020100.51804667
125FoxO signaling pathway_Homo sapiens_hsa040680.51651770
126AMPK signaling pathway_Homo sapiens_hsa041520.51614962
127Hepatitis B_Homo sapiens_hsa051610.49211744
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48461898
129Melanoma_Homo sapiens_hsa052180.47859316
130Pentose phosphate pathway_Homo sapiens_hsa000300.46793433
131VEGF signaling pathway_Homo sapiens_hsa043700.46550167
132Rap1 signaling pathway_Homo sapiens_hsa040150.46438491
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45970612
134beta-Alanine metabolism_Homo sapiens_hsa004100.45439820
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44943303
136Insulin signaling pathway_Homo sapiens_hsa049100.43986029
137TNF signaling pathway_Homo sapiens_hsa046680.43913608
138Hepatitis C_Homo sapiens_hsa051600.41709919
139Apoptosis_Homo sapiens_hsa042100.40888736
140Gap junction_Homo sapiens_hsa045400.40615930
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40578602
142Measles_Homo sapiens_hsa051620.39944528
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.39868872

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