CELSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.77656689
2locomotory exploration behavior (GO:0035641)5.74158769
3synaptic vesicle maturation (GO:0016188)5.52422456
4vocalization behavior (GO:0071625)5.49094632
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48594693
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23975134
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11360768
8synaptic vesicle exocytosis (GO:0016079)4.89764073
9regulation of glutamate receptor signaling pathway (GO:1900449)4.85216443
10glutamate secretion (GO:0014047)4.79602533
11layer formation in cerebral cortex (GO:0021819)4.72705666
12protein localization to synapse (GO:0035418)4.69090595
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.65287184
14neuron cell-cell adhesion (GO:0007158)4.62458076
15dendritic spine morphogenesis (GO:0060997)4.60105694
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.56637078
17exploration behavior (GO:0035640)4.52584320
18regulation of synaptic vesicle exocytosis (GO:2000300)4.44004180
19regulation of neuronal synaptic plasticity (GO:0048168)4.34000162
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.30613821
21glutamate receptor signaling pathway (GO:0007215)4.16075558
22neurotransmitter secretion (GO:0007269)4.09014160
23neuronal action potential propagation (GO:0019227)4.08846869
24synaptic transmission, glutamatergic (GO:0035249)4.05774530
25regulation of synapse structural plasticity (GO:0051823)4.05721543
26neuron recognition (GO:0008038)3.98416350
27regulation of synaptic vesicle transport (GO:1902803)3.93380772
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90991010
29axonal fasciculation (GO:0007413)3.88793888
30neurotransmitter-gated ion channel clustering (GO:0072578)3.88719313
31gamma-aminobutyric acid transport (GO:0015812)3.77938839
32apical protein localization (GO:0045176)3.72348743
33positive regulation of synapse maturation (GO:0090129)3.71813527
34neuron-neuron synaptic transmission (GO:0007270)3.71726342
35cellular potassium ion homeostasis (GO:0030007)3.71446264
36long-term memory (GO:0007616)3.68294462
37positive regulation of membrane potential (GO:0045838)3.63457539
38postsynaptic membrane organization (GO:0001941)3.62077058
39proline transport (GO:0015824)3.61908652
40sodium ion export (GO:0071436)3.61557964
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60445224
42regulation of dendritic spine morphogenesis (GO:0061001)3.57865852
43cerebellar Purkinje cell differentiation (GO:0021702)3.56401094
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55454031
45auditory behavior (GO:0031223)3.49404507
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.49174171
47amino acid import (GO:0043090)3.48497920
48regulation of postsynaptic membrane potential (GO:0060078)3.47388495
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45036770
50regulation of synaptic plasticity (GO:0048167)3.42876000
51neuromuscular process controlling balance (GO:0050885)3.40335032
52central nervous system myelination (GO:0022010)3.39651771
53axon ensheathment in central nervous system (GO:0032291)3.39651771
54innervation (GO:0060384)3.33171686
55neurotransmitter transport (GO:0006836)3.30845484
56cell migration in hindbrain (GO:0021535)3.30627008
57dendritic spine organization (GO:0097061)3.30392079
58central nervous system projection neuron axonogenesis (GO:0021952)3.28323320
59transmission of nerve impulse (GO:0019226)3.26476979
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26241684
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25917243
62synaptic vesicle endocytosis (GO:0048488)3.25470683
63* dendrite morphogenesis (GO:0048813)3.25400803
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25329570
65neuronal ion channel clustering (GO:0045161)3.19644907
66cell communication by electrical coupling (GO:0010644)3.19378507
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.18191826
68response to auditory stimulus (GO:0010996)3.18188335
69activation of protein kinase A activity (GO:0034199)3.18165924
70long-term synaptic potentiation (GO:0060291)3.16183296
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14109333
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14060415
73cerebellar granule cell differentiation (GO:0021707)3.13267193
74presynaptic membrane assembly (GO:0097105)3.12906882
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12882910
76establishment of nucleus localization (GO:0040023)3.11579889
77regulation of neurotransmitter secretion (GO:0046928)3.08948752
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08094635
79gamma-aminobutyric acid signaling pathway (GO:0007214)3.03895918
80regulation of neurotransmitter levels (GO:0001505)3.03837322
81regulation of vesicle fusion (GO:0031338)3.03330162
82asymmetric protein localization (GO:0008105)3.03167366
83positive regulation of dendritic spine development (GO:0060999)3.03009776
84regulation of dendritic spine development (GO:0060998)3.02642781
85synapse assembly (GO:0007416)3.02074587
86establishment of mitochondrion localization (GO:0051654)3.00836151
87presynaptic membrane organization (GO:0097090)3.00605263
88regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.99405556
89membrane hyperpolarization (GO:0060081)2.98856107
90peptidyl-tyrosine autophosphorylation (GO:0038083)2.98784707
91behavioral defense response (GO:0002209)2.98688954
92behavioral fear response (GO:0001662)2.98688954
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98473721
94prepulse inhibition (GO:0060134)2.97940404
95L-amino acid import (GO:0043092)2.97373777
96glycine transport (GO:0015816)2.95783443
97membrane depolarization (GO:0051899)2.95283867
98learning (GO:0007612)2.95260926
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.92880755
100chemosensory behavior (GO:0007635)2.92330199
101social behavior (GO:0035176)2.91358343
102intraspecies interaction between organisms (GO:0051703)2.91358343
103membrane depolarization during action potential (GO:0086010)2.91032534
104synapse organization (GO:0050808)2.90596207
105regulation of neurotransmitter transport (GO:0051588)2.85423344
106neuromuscular process (GO:0050905)2.84641568
107mechanosensory behavior (GO:0007638)2.84455085
108positive regulation of neurotransmitter secretion (GO:0001956)2.84403644
109cochlea development (GO:0090102)2.82451490
110regulation of synaptic transmission (GO:0050804)2.82096292
111hemidesmosome assembly (GO:0031581)2.81930458
112dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80760340
113potassium ion homeostasis (GO:0055075)2.80714316
114adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79117051
115cell communication involved in cardiac conduction (GO:0086065)2.77232692
116regulation of synapse maturation (GO:0090128)2.76668931
117desmosome organization (GO:0002934)2.74696686
118semaphorin-plexin signaling pathway (GO:0071526)2.71114353
119regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.70435059
120regulation of axon extension involved in axon guidance (GO:0048841)2.69256182
121mitochondrion transport along microtubule (GO:0047497)2.69126054
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69126054
123positive regulation of dendrite development (GO:1900006)2.64402686
124cerebellar Purkinje cell layer development (GO:0021680)2.63324046
125negative regulation of dendrite morphogenesis (GO:0050774)2.56048589
126lateral sprouting from an epithelium (GO:0060601)2.55824118
127ephrin receptor signaling pathway (GO:0048013)2.54830920
128cellular sodium ion homeostasis (GO:0006883)2.54734044
129potassium ion import (GO:0010107)2.48518280
130mating behavior (GO:0007617)2.47683748
131positive regulation of synapse assembly (GO:0051965)2.45830219
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45746087
133regulation of ARF protein signal transduction (GO:0032012)2.45577604
134dopamine receptor signaling pathway (GO:0007212)2.44568886
135regulation of axon guidance (GO:1902667)2.44448765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88718654
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.10025059
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14627431
4GBX2_23144817_ChIP-Seq_PC3_Human3.09440403
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07592244
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02225871
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85371458
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85371458
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75503182
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.68438840
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58426891
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58324292
13* ESR2_21235772_ChIP-Seq_MCF-7_Human2.56008105
14DROSHA_22980978_ChIP-Seq_HELA_Human2.51867238
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50381130
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49576902
17REST_21632747_ChIP-Seq_MESCs_Mouse2.48326538
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45712191
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.41939070
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.39823446
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35789879
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.35596412
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34747268
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12790370
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05753641
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04765738
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.99853303
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.97296839
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95634799
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95617473
31AR_21572438_ChIP-Seq_LNCaP_Human1.95064441
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93118478
33* ESR1_21235772_ChIP-Seq_MCF-7_Human1.92885933
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91973820
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89433749
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83623254
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64025718
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63197165
39* ERG_21242973_ChIP-ChIP_JURKAT_Human1.58910692
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55721847
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53337936
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.53100236
43* LXR_22292898_ChIP-Seq_THP-1_Human1.49612081
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48570438
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47786393
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47634126
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45563624
48SMAD4_21799915_ChIP-Seq_A2780_Human1.45357439
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.43921292
50* RACK7_27058665_Chip-Seq_MCF-7_Human1.37428338
51ZNF263_19887448_ChIP-Seq_K562_Human1.37214044
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.36041822
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35755292
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35535105
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.34601674
56* RUNX1_27514584_Chip-Seq_MCF-7_Human1.32452381
57ZNF274_21170338_ChIP-Seq_K562_Hela1.31665864
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30827211
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30688512
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29286368
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28325130
62SMC4_20622854_ChIP-Seq_HELA_Human1.25962443
63CREB1_26743006_Chip-Seq_LNCaP_Human1.25402288
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.24891399
65* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24819027
66* KDM2B_26808549_Chip-Seq_K562_Human1.24779896
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24668521
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.24630618
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23751437
70TAF15_26573619_Chip-Seq_HEK293_Human1.23063120
71* KDM2B_26808549_Chip-Seq_DND41_Human1.22022552
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21781726
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.21524960
74* AR_19668381_ChIP-Seq_PC3_Human1.21240793
75AHR_22903824_ChIP-Seq_MCF-7_Human1.21028323
76* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18452069
77* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18281437
78* TET1_21490601_ChIP-Seq_MESCs_Mouse1.17729372
79P300_19829295_ChIP-Seq_ESCs_Human1.14517282
80AR_25329375_ChIP-Seq_VCAP_Human1.14136818
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12167684
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.11983227
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10819536
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09337504
85* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09203831
86* ISL1_27105846_Chip-Seq_CPCs_Mouse1.07998590
87STAT3_23295773_ChIP-Seq_U87_Human1.07328999
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06869829
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06398133
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05904983
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05825898
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05234338
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05161149
94* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05050068
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.04470458
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02200987
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01984222
98* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00470521
99* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00442824
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00358657
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00124280
102SMAD3_21741376_ChIP-Seq_ESCs_Human0.99351497
103* RNF2_27304074_Chip-Seq_NSC_Mouse0.98958941
104* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98827398
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.97757235
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.97011580
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96339592
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.96306492
109PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95954270
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95537512
111TP53_16413492_ChIP-PET_HCT116_Human0.95393908
112RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94752911
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94196861
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93801206
115TCF4_23295773_ChIP-Seq_U87_Human0.93350089
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93004995
117SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92620790
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91599673
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91592579
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90993490
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90993490
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90523658
123* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90342002
124P68_20966046_ChIP-Seq_HELA_Human0.89851665
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89564116
126RXR_22108803_ChIP-Seq_LS180_Human0.89193506
127* CTCF_27219007_Chip-Seq_Bcells_Human0.88762492
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88668981
129* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88134363
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88095030
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.87948341
132RUNX2_22187159_ChIP-Seq_PCA_Human0.87657189
133TP53_18474530_ChIP-ChIP_U2OS_Human0.87589600
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.86828807
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85990233
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85746674
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85396417
138SMAD_19615063_ChIP-ChIP_OVARY_Human0.85107384
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84077107
140IGF1R_20145208_ChIP-Seq_DFB_Human0.83652053
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83547013
142* TCF7_22412390_ChIP-Seq_EML_Mouse0.83118688
143* TP53_23651856_ChIP-Seq_MEFs_Mouse0.82766748
144* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.81690898
145* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81078163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.49141776
2MP0003880_abnormal_central_pattern4.60810229
3MP0003635_abnormal_synaptic_transmissio4.02509745
4MP0004270_analgesia3.68926335
5MP0002063_abnormal_learning/memory/cond3.21487329
6MP0009745_abnormal_behavioral_response3.18400802
7MP0002064_seizures2.93939626
8MP0005423_abnormal_somatic_nervous2.90837813
9MP0009046_muscle_twitch2.80208357
10MP0000566_synostosis2.75984720
11MP0002572_abnormal_emotion/affect_behav2.64605132
12MP0001968_abnormal_touch/_nociception2.61339700
13MP0001486_abnormal_startle_reflex2.51936547
14MP0002734_abnormal_mechanical_nocicepti2.46478628
15MP0002272_abnormal_nervous_system2.36250728
16MP0000778_abnormal_nervous_system2.35819932
17MP0002822_catalepsy2.08581516
18MP0004858_abnormal_nervous_system2.06037784
19MP0009780_abnormal_chondrocyte_physiolo2.05534305
20MP0001501_abnormal_sleep_pattern1.99642058
21MP0001440_abnormal_grooming_behavior1.92800588
22MP0002184_abnormal_innervation1.92292302
23MP0004885_abnormal_endolymph1.90484366
24MP0008569_lethality_at_weaning1.88868480
25MP0002736_abnormal_nociception_after1.88158346
26MP0002067_abnormal_sensory_capabilities1.85425129
27MP0002735_abnormal_chemical_nociception1.83179366
28MP0003705_abnormal_hypodermis_morpholog1.83106674
29MP0002249_abnormal_larynx_morphology1.83058452
30MP0002733_abnormal_thermal_nociception1.82223774
31MP0002557_abnormal_social/conspecific_i1.77920736
32MP0004811_abnormal_neuron_physiology1.76515840
33MP0001970_abnormal_pain_threshold1.69579133
34MP0000955_abnormal_spinal_cord1.68047413
35MP0003329_amyloid_beta_deposits1.65273510
36MP0003123_paternal_imprinting1.58650985
37MP0005386_behavior/neurological_phenoty1.55232627
38MP0004924_abnormal_behavior1.55232627
39MP0003879_abnormal_hair_cell1.53248518
40MP0002882_abnormal_neuron_morphology1.50797166
41MP0002909_abnormal_adrenal_gland1.49766346
42MP0001984_abnormal_olfaction1.49211864
43MP0006276_abnormal_autonomic_nervous1.46482332
44MP0003787_abnormal_imprinting1.43105696
45MP0005646_abnormal_pituitary_gland1.41866510
46MP0000383_abnormal_hair_follicle1.41572403
47MP0002796_impaired_skin_barrier1.41088797
48MP0002066_abnormal_motor_capabilities/c1.36463092
49* MP0002152_abnormal_brain_morphology1.24661219
50MP0005645_abnormal_hypothalamus_physiol1.24377086
51MP0002098_abnormal_vibrissa_morphology1.23296759
52MP0003633_abnormal_nervous_system1.22610015
53MP0001849_ear_inflammation1.22563144
54MP0001346_abnormal_lacrimal_gland1.21007457
55MP0010030_abnormal_orbit_morphology1.20898287
56MP0005076_abnormal_cell_differentiation1.20338515
57MP0003283_abnormal_digestive_organ1.18752278
58MP0002089_abnormal_postnatal_growth/wei1.18365586
59MP0005394_taste/olfaction_phenotype1.18075541
60MP0005499_abnormal_olfactory_system1.18075541
61MP0010678_abnormal_skin_adnexa1.17048071
62MP0000569_abnormal_digit_pigmentation1.16888610
63MP0010234_abnormal_vibrissa_follicle1.14970560
64MP0004142_abnormal_muscle_tone1.14212599
65MP0001502_abnormal_circadian_rhythm1.13152617
66MP0000462_abnormal_digestive_system1.11425576
67MP0008961_abnormal_basal_metabolism1.09894914
68MP0003122_maternal_imprinting1.09668583
69MP0005377_hearing/vestibular/ear_phenot1.09412177
70MP0003878_abnormal_ear_physiology1.09412177
71MP0004381_abnormal_hair_follicle1.06832464
72MP0003136_yellow_coat_color1.06806262
73MP0000467_abnormal_esophagus_morphology1.05982470
74MP0003631_nervous_system_phenotype1.05401258
75MP0001529_abnormal_vocalization1.04072732
76MP0001177_atelectasis1.03504982
77MP0004742_abnormal_vestibular_system1.03257530
78MP0003942_abnormal_urinary_system1.03024297
79MP0009053_abnormal_anal_canal1.01633779
80MP0009672_abnormal_birth_weight1.01084721
81MP0005248_abnormal_Harderian_gland1.00547783
82MP0000579_abnormal_nail_morphology0.96861352
83MP0000631_abnormal_neuroendocrine_gland0.96550694
84MP0002234_abnormal_pharynx_morphology0.95961060
85MP0000762_abnormal_tongue_morphology0.95480471
86MP0000751_myopathy0.94169499
87MP0002069_abnormal_eating/drinking_beha0.93586253
88MP0003634_abnormal_glial_cell0.92954234
89MP0003861_abnormal_nervous_system0.88294245
90MP0000377_abnormal_hair_follicle0.88293901
91MP0001905_abnormal_dopamine_level0.87902357
92MP0005409_darkened_coat_color0.87301876
93MP0002697_abnormal_eye_size0.86597654
94MP0001485_abnormal_pinna_reflex0.86462151
95MP0001188_hyperpigmentation0.84496336
96MP0002752_abnormal_somatic_nervous0.84285238
97MP0004145_abnormal_muscle_electrophysio0.82772113
98MP0003632_abnormal_nervous_system0.82256025
99MP0001963_abnormal_hearing_physiology0.81919543
100MP0002081_perinatal_lethality0.81009499
101MP0005187_abnormal_penis_morphology0.80847807
102MP0001299_abnormal_eye_distance/0.80812627
103MP0002229_neurodegeneration0.79934774
104MP0005501_abnormal_skin_physiology0.78403599
105MP0000920_abnormal_myelination0.77970566
106MP0003121_genomic_imprinting0.77138718
107MP0003115_abnormal_respiratory_system0.76637983
108MP0002116_abnormal_craniofacial_bone0.74993418
109MP0005551_abnormal_eye_electrophysiolog0.74218980
110MP0003690_abnormal_glial_cell0.74046382
111MP0001348_abnormal_lacrimal_gland0.74016771
112MP0004085_abnormal_heartbeat0.72756751
113MP0005171_absent_coat_pigmentation0.72160605
114MP0000026_abnormal_inner_ear0.72108470
115MP0008872_abnormal_physiological_respon0.71946926
116MP0002653_abnormal_ependyma_morphology0.70732504
117MP0005623_abnormal_meninges_morphology0.69029681
118MP0003938_abnormal_ear_development0.67077147
119MP0004233_abnormal_muscle_weight0.66994211
120MP0003137_abnormal_impulse_conducting0.66484651
121MP0003075_altered_response_to0.66364024
122MP0008874_decreased_physiological_sensi0.66093990
123MP0001943_abnormal_respiration0.65069332
124MP0010769_abnormal_survival0.61717719
125MP0000537_abnormal_urethra_morphology0.61581360
126MP0008789_abnormal_olfactory_epithelium0.61024501
127MP0010770_preweaning_lethality0.59496603
128MP0002082_postnatal_lethality0.59496603
129MP0002090_abnormal_vision0.57823826
130MP0010768_mortality/aging0.57707959
131MP0000013_abnormal_adipose_tissue0.56838450
132MP0000534_abnormal_ureter_morphology0.56519211
133MP0005535_abnormal_body_temperature0.55369040

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.43875659
2Myokymia (HP:0002411)6.13807591
3Focal seizures (HP:0007359)5.10498879
4Visual hallucinations (HP:0002367)4.37025576
5Epileptic encephalopathy (HP:0200134)4.15770694
6Progressive cerebellar ataxia (HP:0002073)4.01828029
7Action tremor (HP:0002345)3.81929679
8Supranuclear gaze palsy (HP:0000605)3.67532848
9Atonic seizures (HP:0010819)3.53699436
10Febrile seizures (HP:0002373)3.50979099
11Broad-based gait (HP:0002136)3.39942633
12Absence seizures (HP:0002121)3.37529836
13Ankle clonus (HP:0011448)3.34747210
14Generalized tonic-clonic seizures (HP:0002069)3.19867572
15Hyperacusis (HP:0010780)3.14605334
16Dialeptic seizures (HP:0011146)3.06782845
17Poor eye contact (HP:0000817)2.94048848
18Impaired vibration sensation in the lower limbs (HP:0002166)2.91850764
19Genetic anticipation (HP:0003743)2.86775566
20Gaze-evoked nystagmus (HP:0000640)2.86472483
21Mutism (HP:0002300)2.84067351
22Depression (HP:0000716)2.83650533
23Dysdiadochokinesis (HP:0002075)2.83088053
24Megalencephaly (HP:0001355)2.82491937
25Urinary bladder sphincter dysfunction (HP:0002839)2.76411046
26Hyperventilation (HP:0002883)2.76410806
27Abnormality of nail color (HP:0100643)2.74816518
28Amblyopia (HP:0000646)2.72980889
29Truncal ataxia (HP:0002078)2.71345091
30Dysmetria (HP:0001310)2.70679127
31Drooling (HP:0002307)2.70408831
32Excessive salivation (HP:0003781)2.70408831
33Impaired social interactions (HP:0000735)2.68958138
34Abnormal social behavior (HP:0012433)2.68958138
35Abnormal eating behavior (HP:0100738)2.60127066
36Postural instability (HP:0002172)2.57738273
37Abnormality of the lower motor neuron (HP:0002366)2.55078894
38Hemiparesis (HP:0001269)2.54655470
39Cerebral inclusion bodies (HP:0100314)2.54353199
40Neurofibrillary tangles (HP:0002185)2.53000893
41Anxiety (HP:0000739)2.52981938
42Obstructive sleep apnea (HP:0002870)2.50454965
43Insidious onset (HP:0003587)2.48018338
44Termporal pattern (HP:0011008)2.48018338
45Urinary urgency (HP:0000012)2.41455092
46Torticollis (HP:0000473)2.39116142
47Split foot (HP:0001839)2.38249049
48Intention tremor (HP:0002080)2.37607866
49Hemiplegia (HP:0002301)2.35940807
50Aplasia involving bones of the extremities (HP:0009825)2.34214179
51Aplasia involving bones of the upper limbs (HP:0009823)2.34214179
52Aplasia of the phalanges of the hand (HP:0009802)2.34214179
53Papilledema (HP:0001085)2.32777977
54Impaired smooth pursuit (HP:0007772)2.32742688
55Stereotypic behavior (HP:0000733)2.31933969
56Turricephaly (HP:0000262)2.30758641
57Insomnia (HP:0100785)2.30613635
58Overriding aorta (HP:0002623)2.30301146
59Spastic gait (HP:0002064)2.29696608
60Scanning speech (HP:0002168)2.19850242
61Epileptiform EEG discharges (HP:0011182)2.19599458
62Abnormality of binocular vision (HP:0011514)2.19582305
63Diplopia (HP:0000651)2.19582305
64Focal dystonia (HP:0004373)2.19119360
65Ventricular fibrillation (HP:0001663)2.16219394
66Abnormality of the corticospinal tract (HP:0002492)2.15538825
67Broad face (HP:0000283)2.12509748
68Pointed chin (HP:0000307)2.10905350
69Aqueductal stenosis (HP:0002410)2.10740567
70EEG with generalized epileptiform discharges (HP:0011198)2.09242517
71Lower limb muscle weakness (HP:0007340)2.04629197
72Absent speech (HP:0001344)2.04370758
73Abnormality of ocular smooth pursuit (HP:0000617)2.03103198
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01016060
75Hypsarrhythmia (HP:0002521)1.99508533
76Bradykinesia (HP:0002067)1.99477226
77Germ cell neoplasia (HP:0100728)1.98980939
78Macroorchidism (HP:0000053)1.98888245
79Shallow orbits (HP:0000586)1.98559929
80Fragile nails (HP:0001808)1.97915418
81Alacrima (HP:0000522)1.96373794
82Milia (HP:0001056)1.95905672
83Progressive inability to walk (HP:0002505)1.95794632
84Fetal akinesia sequence (HP:0001989)1.95078023
85Dysmetric saccades (HP:0000641)1.93974740
86Ankyloglossia (HP:0010296)1.92083445
87Limb dystonia (HP:0002451)1.90813151
88Abnormality of the aortic arch (HP:0012303)1.90306679
89Cutaneous finger syndactyly (HP:0010554)1.90214854
90Polyphagia (HP:0002591)1.90198645
91Craniofacial dystonia (HP:0012179)1.88945941
92Impaired vibratory sensation (HP:0002495)1.88162537
93Inappropriate behavior (HP:0000719)1.85342396
94Abnormality of salivation (HP:0100755)1.83796656
95Increased nuchal translucency (HP:0010880)1.83545849
96Annular pancreas (HP:0001734)1.83506975
97Agitation (HP:0000713)1.82598843
98Amyotrophic lateral sclerosis (HP:0007354)1.81997953
99Akinesia (HP:0002304)1.80794205
100Neoplasm of the heart (HP:0100544)1.80417591
101Arnold-Chiari malformation (HP:0002308)1.80389480
102Cutaneous syndactyly (HP:0012725)1.79937426
103Bowel incontinence (HP:0002607)1.79454668
104Vertebral arch anomaly (HP:0008438)1.79196670
105Renovascular hypertension (HP:0100817)1.77945306
106Incomplete penetrance (HP:0003829)1.77256546
107Lower limb amyotrophy (HP:0007210)1.76040841
108Abnormality of the diencephalon (HP:0010662)1.74673051
109Apathy (HP:0000741)1.74671309
110Hammertoe (HP:0001765)1.74464793
111Morphological abnormality of the inner ear (HP:0011390)1.74224212
112Bronchomalacia (HP:0002780)1.74164065
113Sleep apnea (HP:0010535)1.73218725
114High anterior hairline (HP:0009890)1.70821048
115Anosmia (HP:0000458)1.70715415
116Trigonocephaly (HP:0000243)1.68551556
117Peripheral hypomyelination (HP:0007182)1.68260288
118Blue irides (HP:0000635)1.67566637
119Precocious puberty (HP:0000826)1.67163214
120Status epilepticus (HP:0002133)1.66928949
121Partial duplication of thumb phalanx (HP:0009944)1.66720166
122Tracheomalacia (HP:0002779)1.65993792
123Neuronal loss in central nervous system (HP:0002529)1.65881809
124Onycholysis (HP:0001806)1.65782811
125Lower limb asymmetry (HP:0100559)1.65680344
126Autism (HP:0000717)1.65471933
127Pili torti (HP:0003777)1.64415205
128Exotropia (HP:0000577)1.64136189
129Generalized myoclonic seizures (HP:0002123)1.64133296
130Urethral obstruction (HP:0000796)1.63769240
131Ulnar bowing (HP:0003031)1.62988882
132Heterotopia (HP:0002282)1.62075291
133Gait ataxia (HP:0002066)1.61943124
134Increased circulating renin level (HP:0000848)1.61912774
135Elfin facies (HP:0004428)1.61563063
136Heterochromia iridis (HP:0001100)1.60588104
137Rapidly progressive (HP:0003678)1.60302462
138Renal duplication (HP:0000075)1.59589686
139Pterygium (HP:0001059)1.59260526
140Abnormal large intestine physiology (HP:0012700)1.58957546
141Advanced eruption of teeth (HP:0006288)1.58931190
142Laryngomalacia (HP:0001601)1.56534960
143Abnormality of the salivary glands (HP:0010286)1.56116098
144Septate vagina (HP:0001153)1.55529097
145Asymmetry of the thorax (HP:0001555)1.55375666
146Morphological abnormality of the middle ear (HP:0008609)1.54980799
147Atrophic scars (HP:0001075)1.54869256
148Coronal craniosynostosis (HP:0004440)1.54854973
149Obsessive-compulsive behavior (HP:0000722)1.53404265
150Spina bifida occulta (HP:0003298)1.53277317
151Cerebral aneurysm (HP:0004944)1.53003758
152Renal dysplasia (HP:0000110)1.49176458
153Thin ribs (HP:0000883)1.48356444
154Abnormality of permanent molar morphology (HP:0011071)1.48142048
155Abnormality of the dental root (HP:0006486)1.48142048
156Taurodontia (HP:0000679)1.48142048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.38284376
2EPHA44.30985610
3MARK13.75668266
4MAP3K93.66212033
5TRIB33.44607991
6MAP3K42.70485365
7MINK12.57778633
8NTRK22.47067287
9DAPK22.46612954
10SIK12.37702641
11PAK62.31600444
12PRKD32.02986789
13MAP2K72.01994252
14KSR11.83774489
15CAMKK11.82579865
16NTRK11.81594925
17EEF2K1.80662901
18KSR21.73886759
19PKN21.70185106
20TNIK1.69828652
21CASK1.67239133
22SIK21.58203785
23CDK51.57016736
24MAP2K41.55342726
25MAPK131.54488568
26CDK121.46017428
27SMG11.45669557
28RIPK41.40400242
29MUSK1.39828849
30PNCK1.39784233
31DAPK11.38745354
32STK381.34681246
33UHMK11.32375014
34TYRO31.30359457
35PRPF4B1.24557126
36PLK21.23909080
37MAP3K121.21352804
38CDK191.20200427
39PHKG21.17421118
40PHKG11.17421118
41PRKCG1.13514160
42LATS21.12009780
43TAOK11.11307259
44MAP3K21.10542334
45SGK4941.02152585
46SGK2231.02152585
47STK110.98918920
48GRK50.97979546
49MAP3K100.97813423
50MTOR0.97720329
51RPS6KB20.96263894
52PDGFRA0.96120545
53CAMK1G0.93400861
54EPHB20.92828145
55CAMK2A0.92244144
56CDK180.90907409
57MARK20.90694031
58CDK150.89903470
59FES0.89579079
60OXSR10.89327506
61CAMK10.88819414
62PAK30.88059752
63CDK140.85216103
64MAPKAPK30.83608956
65RET0.81434311
66FER0.79439990
67SCYL20.79385108
68CAMK2G0.79027750
69CDK11A0.78741171
70CAMK2B0.78551184
71ALK0.78254995
72DYRK1A0.78220765
73FGFR40.77547834
74SGK20.77197864
75SGK10.76987430
76PRKCH0.75357286
77BRD40.73485671
78CSNK1G20.72981382
79FGFR20.69879044
80EPHA20.68373668
81SGK30.68215167
82LMTK20.64624274
83RIPK10.63761989
84MAP2K20.63268158
85WNK30.63189252
86RPS6KB10.62846372
87PTK20.61782119
88CDC42BPA0.61407325
89PRKCZ0.60668711
90CAMK1D0.60274707
91MAP3K70.57453587
92NEK60.56044822
93PTK2B0.55948273
94ARAF0.55171766
95FGFR10.54583375
96PIK3CA0.53775284
97MAP3K130.53534695
98CAMKK20.52619438
99RPS6KA30.52349024
100ICK0.51076073
101FYN0.50940810
102EPHA30.49893490
103DYRK20.49449115
104MAPK80.49345686
105CAMK2D0.48938466
106DDR20.48475489
107ROCK20.48187792
108ERBB30.47500238
109CAMK40.47301633
110DMPK0.47231026
111RAF10.46252734
112MAPK100.44837791
113PDK10.44605105
114WNK40.44177799
115PTK60.44127328
116ERBB20.44089622
117DYRK1B0.43747418
118WNK10.43690967
119PRKCE0.43563567
120PDPK10.43153119
121RPS6KA20.42838468
122BCR0.42583505
123GSK3B0.41734779
124MAP3K10.41544245
125STK390.40626169
126TESK10.40020439
127TNK20.39604156
128PKN10.38352666
129MAPK150.37915061
130BRAF0.37207675
131BRSK10.36901715
132FGR0.36686211
133NME10.36581214

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52143834
2Synaptic vesicle cycle_Homo sapiens_hsa047212.90029863
3Circadian entrainment_Homo sapiens_hsa047132.61729898
4Long-term potentiation_Homo sapiens_hsa047202.56868285
5Glutamatergic synapse_Homo sapiens_hsa047242.54780014
6Olfactory transduction_Homo sapiens_hsa047402.53466242
7GABAergic synapse_Homo sapiens_hsa047272.51408382
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47484729
9Morphine addiction_Homo sapiens_hsa050322.30057165
10Amphetamine addiction_Homo sapiens_hsa050312.29589177
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21732058
12Salivary secretion_Homo sapiens_hsa049702.16869289
13Dopaminergic synapse_Homo sapiens_hsa047282.04849375
14Gastric acid secretion_Homo sapiens_hsa049711.95326641
15Insulin secretion_Homo sapiens_hsa049111.91767634
16Cholinergic synapse_Homo sapiens_hsa047251.85795705
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78207952
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66009121
19Renin secretion_Homo sapiens_hsa049241.64907104
20Taste transduction_Homo sapiens_hsa047421.64479549
21Long-term depression_Homo sapiens_hsa047301.63749795
22Cocaine addiction_Homo sapiens_hsa050301.61957782
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61171468
24Axon guidance_Homo sapiens_hsa043601.58522531
25Serotonergic synapse_Homo sapiens_hsa047261.54620131
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54061400
27Calcium signaling pathway_Homo sapiens_hsa040201.52625439
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43847238
29GnRH signaling pathway_Homo sapiens_hsa049121.43819616
30Notch signaling pathway_Homo sapiens_hsa043301.41512569
31Gap junction_Homo sapiens_hsa045401.40934155
32cAMP signaling pathway_Homo sapiens_hsa040241.29086774
33Melanogenesis_Homo sapiens_hsa049161.28594101
34Glioma_Homo sapiens_hsa052141.26333777
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26029316
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23396910
37Estrogen signaling pathway_Homo sapiens_hsa049151.23279268
38Type II diabetes mellitus_Homo sapiens_hsa049301.22856630
39ErbB signaling pathway_Homo sapiens_hsa040121.17663409
40Collecting duct acid secretion_Homo sapiens_hsa049661.15599313
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14693175
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.11427519
43Vitamin B6 metabolism_Homo sapiens_hsa007501.10496481
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07931570
45Dorso-ventral axis formation_Homo sapiens_hsa043201.04261005
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02995721
47Pancreatic secretion_Homo sapiens_hsa049720.96587983
48AMPK signaling pathway_Homo sapiens_hsa041520.93756896
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92019664
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.88946324
51Thyroid cancer_Homo sapiens_hsa052160.87878004
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.87212824
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87182213
54Adherens junction_Homo sapiens_hsa045200.86961614
55Oocyte meiosis_Homo sapiens_hsa041140.84380930
56Dilated cardiomyopathy_Homo sapiens_hsa054140.83189600
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82622590
58Cardiac muscle contraction_Homo sapiens_hsa042600.81328278
59Thyroid hormone synthesis_Homo sapiens_hsa049180.81184801
60Nitrogen metabolism_Homo sapiens_hsa009100.80524572
61Choline metabolism in cancer_Homo sapiens_hsa052310.78836712
62Chronic myeloid leukemia_Homo sapiens_hsa052200.75955731
63Wnt signaling pathway_Homo sapiens_hsa043100.75456155
64Endometrial cancer_Homo sapiens_hsa052130.74838038
65MAPK signaling pathway_Homo sapiens_hsa040100.73773347
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73528650
67Phototransduction_Homo sapiens_hsa047440.73421482
68Vibrio cholerae infection_Homo sapiens_hsa051100.73337640
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72426964
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71010910
71VEGF signaling pathway_Homo sapiens_hsa043700.70905670
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.70493630
73MicroRNAs in cancer_Homo sapiens_hsa052060.70141572
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69041102
75Hedgehog signaling pathway_Homo sapiens_hsa043400.68912327
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68501737
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68466652
78Lysine degradation_Homo sapiens_hsa003100.67591717
79Rap1 signaling pathway_Homo sapiens_hsa040150.66053609
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65731707
81Ras signaling pathway_Homo sapiens_hsa040140.65142763
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64122042
83ECM-receptor interaction_Homo sapiens_hsa045120.61862525
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61154450
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60997434
86Renal cell carcinoma_Homo sapiens_hsa052110.59502565
87Basal cell carcinoma_Homo sapiens_hsa052170.59292816
88mTOR signaling pathway_Homo sapiens_hsa041500.59149072
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58193868
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57687111
91Non-small cell lung cancer_Homo sapiens_hsa052230.55409055
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.55346259
93Glucagon signaling pathway_Homo sapiens_hsa049220.54723376
94Prolactin signaling pathway_Homo sapiens_hsa049170.52071023
95Bladder cancer_Homo sapiens_hsa052190.51226551
96Endocytosis_Homo sapiens_hsa041440.50905700
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50338998
98Hippo signaling pathway_Homo sapiens_hsa043900.49579425
99Focal adhesion_Homo sapiens_hsa045100.49511011
100Melanoma_Homo sapiens_hsa052180.49438178
101Alcoholism_Homo sapiens_hsa050340.48862590
102Colorectal cancer_Homo sapiens_hsa052100.47542515
103Bile secretion_Homo sapiens_hsa049760.47309873
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46844225
105Insulin signaling pathway_Homo sapiens_hsa049100.44576361
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44433934
107Circadian rhythm_Homo sapiens_hsa047100.43100925
108Tight junction_Homo sapiens_hsa045300.42017907
109Inositol phosphate metabolism_Homo sapiens_hsa005620.41775075
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41528791
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38232042
112Prion diseases_Homo sapiens_hsa050200.37230437
113Ovarian steroidogenesis_Homo sapiens_hsa049130.32873490
114Fatty acid biosynthesis_Homo sapiens_hsa000610.32694916
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30301071
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28274675
117Proteoglycans in cancer_Homo sapiens_hsa052050.28233778
118Chemokine signaling pathway_Homo sapiens_hsa040620.27905893

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