CELSR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25729461
2synaptic vesicle maturation (GO:0016188)5.93016078
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.81406132
4locomotory exploration behavior (GO:0035641)5.70998349
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42988591
6vocalization behavior (GO:0071625)5.26536099
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99686414
8synaptic vesicle exocytosis (GO:0016079)4.93147260
9layer formation in cerebral cortex (GO:0021819)4.84328641
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.76230197
11regulation of synaptic vesicle exocytosis (GO:2000300)4.73273609
12glutamate secretion (GO:0014047)4.64256021
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.61872518
14regulation of glutamate receptor signaling pathway (GO:1900449)4.60655472
15protein localization to synapse (GO:0035418)4.58578088
16neuron cell-cell adhesion (GO:0007158)4.46458857
17neurotransmitter secretion (GO:0007269)4.39629402
18dendritic spine morphogenesis (GO:0060997)4.39291406
19exploration behavior (GO:0035640)4.32443649
20cerebellar Purkinje cell differentiation (GO:0021702)4.27303037
21regulation of neuronal synaptic plasticity (GO:0048168)4.25570455
22response to pheromone (GO:0019236)4.25023481
23regulation of synapse structural plasticity (GO:0051823)4.20395745
24regulation of synaptic vesicle transport (GO:1902803)4.17577856
25synaptic transmission, glutamatergic (GO:0035249)4.15669542
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12981134
27glutamate receptor signaling pathway (GO:0007215)4.06305124
28gamma-aminobutyric acid transport (GO:0015812)4.03918315
29neuronal action potential propagation (GO:0019227)4.03506147
30presynaptic membrane assembly (GO:0097105)4.00475788
31establishment of mitochondrion localization (GO:0051654)3.98707739
32positive regulation of synapse maturation (GO:0090129)3.95200643
33presynaptic membrane organization (GO:0097090)3.93765905
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90887791
35mitochondrion transport along microtubule (GO:0047497)3.84101806
36establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.84101806
37dendrite morphogenesis (GO:0048813)3.79335774
38neuron-neuron synaptic transmission (GO:0007270)3.76605367
39cellular potassium ion homeostasis (GO:0030007)3.75730756
40cell migration in hindbrain (GO:0021535)3.75499528
41long-term memory (GO:0007616)3.75376750
42sodium ion export (GO:0071436)3.73952897
43proline transport (GO:0015824)3.70674707
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70637170
45auditory behavior (GO:0031223)3.68500008
46neurotransmitter-gated ion channel clustering (GO:0072578)3.68211946
47positive regulation of membrane potential (GO:0045838)3.65439883
48neuromuscular process controlling balance (GO:0050885)3.61120398
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58790884
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56873146
51* neuron recognition (GO:0008038)3.56632521
52transmission of nerve impulse (GO:0019226)3.50855664
53neurotransmitter transport (GO:0006836)3.49911352
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49118238
55regulation of postsynaptic membrane potential (GO:0060078)3.47619247
56synaptic vesicle endocytosis (GO:0048488)3.44837739
57cerebellar granule cell differentiation (GO:0021707)3.43212988
58activation of protein kinase A activity (GO:0034199)3.43058865
59cell communication by electrical coupling (GO:0010644)3.42261742
60cerebellar Purkinje cell layer development (GO:0021680)3.42184547
61neuronal ion channel clustering (GO:0045161)3.41995823
62central nervous system projection neuron axonogenesis (GO:0021952)3.39846299
63spinal cord development (GO:0021510)3.37636376
64regulation of dendritic spine morphogenesis (GO:0061001)3.37005926
65membrane depolarization during action potential (GO:0086010)3.35906451
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33158301
67nucleobase catabolic process (GO:0046113)3.31140426
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29418600
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29301967
70prepulse inhibition (GO:0060134)3.29262530
71* axonal fasciculation (GO:0007413)3.28685759
72regulation of neurotransmitter secretion (GO:0046928)3.27434399
73response to auditory stimulus (GO:0010996)3.26955334
74establishment of nucleus localization (GO:0040023)3.24357747
75regulation of NFAT protein import into nucleus (GO:0051532)3.24147282
76cell differentiation in hindbrain (GO:0021533)3.23057503
77neuromuscular process controlling posture (GO:0050884)3.22675975
78regulation of synaptic plasticity (GO:0048167)3.22546023
79glycine transport (GO:0015816)3.22262626
80membrane hyperpolarization (GO:0060081)3.22192753
81regulation of neurotransmitter levels (GO:0001505)3.21382666
82chemosensory behavior (GO:0007635)3.18381269
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.17620917
84regulation of ARF protein signal transduction (GO:0032012)3.16392393
85regulation of vesicle fusion (GO:0031338)3.15802561
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15542538
87pyrimidine nucleobase catabolic process (GO:0006208)3.14608092
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13537044
89membrane depolarization (GO:0051899)3.12596699
90innervation (GO:0060384)3.12405080
91positive regulation of dendritic spine development (GO:0060999)3.10356647
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09824325
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.09669816
94postsynaptic membrane organization (GO:0001941)3.06116949
95dendritic spine organization (GO:0097061)3.05512585
96adult walking behavior (GO:0007628)3.04246653
97cerebellum development (GO:0021549)3.03699906
98mechanosensory behavior (GO:0007638)3.01495711
99mating behavior (GO:0007617)3.01438323
100negative regulation of microtubule polymerization (GO:0031115)3.00944703
101synapse assembly (GO:0007416)2.99735333
102regulation of neurotransmitter transport (GO:0051588)2.99371445
103neuromuscular synaptic transmission (GO:0007274)2.98584075
104regulation of synapse maturation (GO:0090128)2.98287986
105gamma-aminobutyric acid signaling pathway (GO:0007214)2.95949052
106intraspecies interaction between organisms (GO:0051703)2.94932189
107social behavior (GO:0035176)2.94932189
108positive regulation of neurotransmitter secretion (GO:0001956)2.94446825
109vesicle transport along microtubule (GO:0047496)2.92767128
110protein-DNA complex disassembly (GO:0032986)2.81736474
111nucleosome disassembly (GO:0006337)2.81736474
112pre-miRNA processing (GO:0031054)2.81168755
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79987788
114neural tube development (GO:0021915)2.77986580
115semaphorin-plexin signaling pathway (GO:0071526)2.77068001
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.75843126
117synapse organization (GO:0050808)2.73173036
118stress granule assembly (GO:0034063)2.71589550
119embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69249519
120cell-cell junction maintenance (GO:0045217)2.68547779
121regulation of dendrite morphogenesis (GO:0048814)2.66074829
122apical protein localization (GO:0045176)2.60120814
123regulation of respiratory system process (GO:0044065)2.59938517
124body morphogenesis (GO:0010171)2.58343536
125axon extension (GO:0048675)2.56291280
126positive regulation of synapse assembly (GO:0051965)2.56068398
127positive regulation of neurotransmitter transport (GO:0051590)2.54607002
128positive regulation of dendrite development (GO:1900006)2.53855257
129ganglion development (GO:0061548)2.53287259
130dopamine receptor signaling pathway (GO:0007212)2.52789448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23943747
2GBX2_23144817_ChIP-Seq_PC3_Human2.99433472
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97694717
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.97473691
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93343081
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89334967
7DROSHA_22980978_ChIP-Seq_HELA_Human2.87117012
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.73382791
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70403258
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70403258
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63017945
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.57302428
13* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55316279
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48087173
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46935455
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43934851
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43765431
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.42432595
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.40702520
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37750027
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36968165
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36127662
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33353130
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31193128
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29023540
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.27108021
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19109031
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.17996625
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91879239
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80073884
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74249556
32* ERG_21242973_ChIP-ChIP_JURKAT_Human1.65478865
33ZNF274_21170338_ChIP-Seq_K562_Hela1.63404549
34AR_21572438_ChIP-Seq_LNCaP_Human1.56335819
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55802841
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53003101
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49755599
38KDM2B_26808549_Chip-Seq_K562_Human1.48993790
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47683098
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46987253
41* RING1B_27294783_Chip-Seq_ESCs_Mouse1.45197855
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44368063
43SMAD4_21799915_ChIP-Seq_A2780_Human1.37718185
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33271903
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.32695071
46* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32642374
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32619949
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.32510190
49AR_19668381_ChIP-Seq_PC3_Human1.30697840
50* LXR_22292898_ChIP-Seq_THP-1_Human1.30351886
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29554033
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.28399808
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28271660
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.27481492
55* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25177210
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23699008
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23268840
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22330122
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21275760
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.21000061
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20173054
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19640466
63* CREB1_26743006_Chip-Seq_LNCaP_Human1.19564717
64SMC4_20622854_ChIP-Seq_HELA_Human1.18576212
65KDM2B_26808549_Chip-Seq_DND41_Human1.18477125
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18041264
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16207327
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15523830
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13013999
70* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12982089
71* STAT3_23295773_ChIP-Seq_U87_Human1.11816551
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11723526
73IGF1R_20145208_ChIP-Seq_DFB_Human1.10645202
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10591592
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10165352
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08864184
77* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08622926
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.07316114
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07234454
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07212146
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06632596
82RNF2_27304074_Chip-Seq_NSC_Mouse1.05872141
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05482263
84* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03954751
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02173862
86AR_25329375_ChIP-Seq_VCAP_Human1.01897738
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.00378790
88* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99156776
89TET1_21490601_ChIP-Seq_MESCs_Mouse0.99150806
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98213081
91* P68_20966046_ChIP-Seq_HELA_Human0.97544942
92TCF4_23295773_ChIP-Seq_U87_Human0.96549899
93TAF15_26573619_Chip-Seq_HEK293_Human0.96464992
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.95954753
95P300_19829295_ChIP-Seq_ESCs_Human0.95867245
96SOX3_22085726_ChIP-Seq_NPCs_Mouse0.95565748
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.95331231
98* CTCF_27219007_Chip-Seq_Bcells_Human0.94685823
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94499894
100NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94473184
101TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94215389
102AHR_22903824_ChIP-Seq_MCF-7_Human0.93763299
103RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93623353
104ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93029726
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92736951
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92092960
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92092960
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91773144
109OCT4_19829295_ChIP-Seq_ESCs_Human0.90573739
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.89321886
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88882045
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88780059
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88263712
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87926816
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85930247
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85506606
117RUNX2_22187159_ChIP-Seq_PCA_Human0.85383295
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.85033635
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84489952
120TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82756395
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82430229
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81866317
123TCF7_22412390_ChIP-Seq_EML_Mouse0.81695299
124TP53_23651856_ChIP-Seq_MEFs_Mouse0.81602481
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.81123894
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80944107
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80809308
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80598988
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.80434141
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80012487
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79084347
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78520042
133* KDM2B_26808549_Chip-Seq_JURKAT_Human0.78511056
134* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78238867
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77880858
136POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77161765
137RACK7_27058665_Chip-Seq_MCF-7_Human0.76953574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.37297516
2MP0003880_abnormal_central_pattern4.04441094
3MP0003635_abnormal_synaptic_transmissio3.96556502
4MP0004270_analgesia3.68066297
5MP0005423_abnormal_somatic_nervous3.41676300
6MP0002063_abnormal_learning/memory/cond3.15653306
7MP0009046_muscle_twitch3.09309348
8MP0009745_abnormal_behavioral_response3.08005678
9MP0002064_seizures2.88901681
10MP0002734_abnormal_mechanical_nocicepti2.66231589
11MP0002572_abnormal_emotion/affect_behav2.61615661
12MP0001968_abnormal_touch/_nociception2.51389970
13MP0001486_abnormal_startle_reflex2.38843196
14MP0002272_abnormal_nervous_system2.38211221
15MP0002822_catalepsy2.30739958
16MP0003123_paternal_imprinting2.22095283
17* MP0000778_abnormal_nervous_system2.14462378
18MP0002735_abnormal_chemical_nociception2.08430217
19MP0002909_abnormal_adrenal_gland2.07521145
20MP0002733_abnormal_thermal_nociception2.03658732
21MP0008569_lethality_at_weaning2.03090874
22* MP0002184_abnormal_innervation2.02819382
23MP0002067_abnormal_sensory_capabilities1.93051866
24MP0001440_abnormal_grooming_behavior1.92493636
25* MP0004811_abnormal_neuron_physiology1.91979813
26MP0001501_abnormal_sleep_pattern1.90742499
27MP0009780_abnormal_chondrocyte_physiolo1.88046015
28MP0001970_abnormal_pain_threshold1.87815925
29MP0002557_abnormal_social/conspecific_i1.85440679
30MP0000569_abnormal_digit_pigmentation1.85214951
31MP0000955_abnormal_spinal_cord1.79333818
32MP0004858_abnormal_nervous_system1.78449621
33MP0006276_abnormal_autonomic_nervous1.77374041
34MP0005645_abnormal_hypothalamus_physiol1.72241873
35MP0002736_abnormal_nociception_after1.69877510
36MP0004924_abnormal_behavior1.68477896
37MP0005386_behavior/neurological_phenoty1.68477896
38MP0001984_abnormal_olfaction1.67049319
39MP0003787_abnormal_imprinting1.66940360
40MP0003283_abnormal_digestive_organ1.63438378
41MP0001348_abnormal_lacrimal_gland1.60763932
42MP0004885_abnormal_endolymph1.59519389
43MP0005409_darkened_coat_color1.59163856
44* MP0002882_abnormal_neuron_morphology1.57948217
45MP0003329_amyloid_beta_deposits1.56704535
46MP0005646_abnormal_pituitary_gland1.53814465
47MP0002653_abnormal_ependyma_morphology1.44818303
48MP0000566_synostosis1.43488157
49MP0002249_abnormal_larynx_morphology1.42778688
50MP0003122_maternal_imprinting1.42513063
51* MP0002066_abnormal_motor_capabilities/c1.41366187
52MP0001502_abnormal_circadian_rhythm1.37009738
53MP0008961_abnormal_basal_metabolism1.35766027
54MP0003879_abnormal_hair_cell1.34922188
55MP0003119_abnormal_digestive_system1.33929842
56* MP0002152_abnormal_brain_morphology1.30007564
57MP0004145_abnormal_muscle_electrophysio1.25356446
58MP0005394_taste/olfaction_phenotype1.23625741
59MP0005499_abnormal_olfactory_system1.23625741
60MP0003890_abnormal_embryonic-extraembry1.23377348
61MP0005551_abnormal_eye_electrophysiolog1.22792847
62MP0003633_abnormal_nervous_system1.20243289
63MP0009672_abnormal_birth_weight1.19330455
64MP0001529_abnormal_vocalization1.18704587
65MP0006072_abnormal_retinal_apoptosis1.15322942
66MP0002638_abnormal_pupillary_reflex1.14319648
67MP0004142_abnormal_muscle_tone1.13941604
68MP0000631_abnormal_neuroendocrine_gland1.09892451
69MP0000537_abnormal_urethra_morphology1.07653084
70MP0003942_abnormal_urinary_system1.06280681
71MP0002229_neurodegeneration1.05818465
72MP0000579_abnormal_nail_morphology1.05011266
73MP0003631_nervous_system_phenotype1.04207252
74MP0004133_heterotaxia1.03680256
75MP0002069_abnormal_eating/drinking_beha1.03025520
76MP0000534_abnormal_ureter_morphology1.03013295
77MP0005377_hearing/vestibular/ear_phenot1.01334448
78MP0003878_abnormal_ear_physiology1.01334448
79MP0002089_abnormal_postnatal_growth/wei0.98854370
80MP0005187_abnormal_penis_morphology0.98558447
81MP0004742_abnormal_vestibular_system0.97413937
82* MP0002081_perinatal_lethality0.94949413
83MP0010386_abnormal_urinary_bladder0.94572160
84MP0002752_abnormal_somatic_nervous0.92500777
85MP0003938_abnormal_ear_development0.92033928
86MP0001299_abnormal_eye_distance/0.91958691
87MP0003183_abnormal_peptide_metabolism0.91729756
88MP0005076_abnormal_cell_differentiation0.91446798
89MP0003115_abnormal_respiratory_system0.91307245
90MP0003385_abnormal_body_wall0.90469290
91MP0003632_abnormal_nervous_system0.89313507
92MP0002697_abnormal_eye_size0.87888585
93* MP0003861_abnormal_nervous_system0.87682197
94MP0001905_abnormal_dopamine_level0.87077079
95MP0003172_abnormal_lysosome_physiology0.86526982
96MP0003634_abnormal_glial_cell0.84819764
97MP0003137_abnormal_impulse_conducting0.83716775
98MP0000013_abnormal_adipose_tissue0.83615341
99MP0005253_abnormal_eye_physiology0.82417078
100MP0004085_abnormal_heartbeat0.81357952
101MP0001346_abnormal_lacrimal_gland0.79539738
102MP0000751_myopathy0.78327762
103MP0002234_abnormal_pharynx_morphology0.78276754
104MP0001177_atelectasis0.77973685
105MP0001188_hyperpigmentation0.76688693
106MP0002116_abnormal_craniofacial_bone0.76490694
107MP0008872_abnormal_physiological_respon0.74148039
108MP0001963_abnormal_hearing_physiology0.71977955
109MP0009053_abnormal_anal_canal0.71265121
110MP0003937_abnormal_limbs/digits/tail_de0.69869636
111MP0005535_abnormal_body_temperature0.68938532
112MP0000049_abnormal_middle_ear0.68822706
113MP0006292_abnormal_olfactory_placode0.68724528
114MP0003121_genomic_imprinting0.68074350
115MP0008789_abnormal_olfactory_epithelium0.65875084
116MP0003690_abnormal_glial_cell0.65261733
117MP0010769_abnormal_survival0.64956742
118MP0010770_preweaning_lethality0.63087298
119MP0002082_postnatal_lethality0.63087298
120MP0004233_abnormal_muscle_weight0.62205111
121MP0010768_mortality/aging0.61686207
122MP0002751_abnormal_autonomic_nervous0.61574654
123MP0002090_abnormal_vision0.60560161
124MP0008874_decreased_physiological_sensi0.58971377
125MP0001485_abnormal_pinna_reflex0.58340916
126* MP0001943_abnormal_respiration0.58142906
127MP0004043_abnormal_pH_regulation0.56762864

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.94267243
2Myokymia (HP:0002411)5.91786889
3Focal seizures (HP:0007359)5.20711181
4Visual hallucinations (HP:0002367)4.91805495
5Progressive cerebellar ataxia (HP:0002073)4.36377524
6Epileptic encephalopathy (HP:0200134)4.09429871
7Action tremor (HP:0002345)4.04299754
8Febrile seizures (HP:0002373)3.72090697
9Supranuclear gaze palsy (HP:0000605)3.70276490
10Ankle clonus (HP:0011448)3.47129934
11Absence seizures (HP:0002121)3.40613504
12Atonic seizures (HP:0010819)3.39004400
13Broad-based gait (HP:0002136)3.38949329
14Poor eye contact (HP:0000817)3.27337375
15Gaze-evoked nystagmus (HP:0000640)3.20551557
16Genetic anticipation (HP:0003743)3.16360143
17Generalized tonic-clonic seizures (HP:0002069)3.14977522
18Hepatoblastoma (HP:0002884)3.11396208
19Depression (HP:0000716)3.07540765
20Dialeptic seizures (HP:0011146)3.06309678
21Abnormality of the lower motor neuron (HP:0002366)3.05419643
22Truncal ataxia (HP:0002078)3.03486060
23Impaired smooth pursuit (HP:0007772)3.02953245
24Impaired vibration sensation in the lower limbs (HP:0002166)3.02020345
25Hemiparesis (HP:0001269)3.00232162
26Abnormal social behavior (HP:0012433)2.97480945
27Impaired social interactions (HP:0000735)2.97480945
28Dysdiadochokinesis (HP:0002075)2.93609238
29Papilledema (HP:0001085)2.93470482
30Urinary bladder sphincter dysfunction (HP:0002839)2.93175190
31Mutism (HP:0002300)2.88478416
32Amblyopia (HP:0000646)2.77553217
33Abnormality of ocular smooth pursuit (HP:0000617)2.75051222
34Insomnia (HP:0100785)2.74700134
35Dysmetria (HP:0001310)2.71582388
36Abnormal eating behavior (HP:0100738)2.67292628
37Drooling (HP:0002307)2.66966470
38Excessive salivation (HP:0003781)2.66966470
39Anxiety (HP:0000739)2.64893561
40Agitation (HP:0000713)2.64352741
41Spastic gait (HP:0002064)2.64153263
42Postural instability (HP:0002172)2.60596165
43Renovascular hypertension (HP:0100817)2.60555259
44Hemiplegia (HP:0002301)2.54776373
45Urinary urgency (HP:0000012)2.53406543
46Abnormality of the aortic arch (HP:0012303)2.52244975
47Epileptiform EEG discharges (HP:0011182)2.50164312
48EEG with generalized epileptiform discharges (HP:0011198)2.49298277
49Abnormality of the corticospinal tract (HP:0002492)2.49092674
50Amyotrophic lateral sclerosis (HP:0007354)2.49055934
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45786468
52Intention tremor (HP:0002080)2.44092717
53Pointed chin (HP:0000307)2.43576235
54Hypsarrhythmia (HP:0002521)2.43451697
55Scanning speech (HP:0002168)2.38229471
56Turricephaly (HP:0000262)2.37923914
57Torticollis (HP:0000473)2.36631127
58High anterior hairline (HP:0009890)2.34935363
59Limb dystonia (HP:0002451)2.34761798
60Trigonocephaly (HP:0000243)2.33580416
61Diplopia (HP:0000651)2.33524908
62Abnormality of binocular vision (HP:0011514)2.33524908
63Stereotypic behavior (HP:0000733)2.33001182
64Hyperacusis (HP:0010780)2.30135311
65Hyperventilation (HP:0002883)2.26665529
66Neoplasm of the heart (HP:0100544)2.23894550
67Dysmetric saccades (HP:0000641)2.22803861
68Ventricular fibrillation (HP:0001663)2.19314779
69Megalencephaly (HP:0001355)2.18879934
70Elfin facies (HP:0004428)2.16388682
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14863569
72Focal dystonia (HP:0004373)2.13753339
73Lower limb muscle weakness (HP:0007340)2.13572677
74Aqueductal stenosis (HP:0002410)2.13280964
75Increased nuchal translucency (HP:0010880)2.07713269
76Bradykinesia (HP:0002067)2.06162001
77Macroorchidism (HP:0000053)2.04455047
78Bronchomalacia (HP:0002780)2.04274967
79Cerebral inclusion bodies (HP:0100314)2.04068271
80Renal duplication (HP:0000075)2.03557049
81Progressive inability to walk (HP:0002505)2.03475136
82Clonus (HP:0002169)2.03227388
83Termporal pattern (HP:0011008)2.03223095
84Insidious onset (HP:0003587)2.03223095
85Spina bifida occulta (HP:0003298)2.03167592
86Absent speech (HP:0001344)2.02297834
87Neurofibrillary tangles (HP:0002185)2.02250418
88Failure to thrive in infancy (HP:0001531)2.00807434
89Precocious puberty (HP:0000826)2.00559026
90Pheochromocytoma (HP:0002666)1.98919992
91Deep palmar crease (HP:0006191)1.97855437
92Polyphagia (HP:0002591)1.97009169
93Cutaneous finger syndactyly (HP:0010554)1.95626832
94Inappropriate behavior (HP:0000719)1.95188087
95Status epilepticus (HP:0002133)1.94659922
96Neuronal loss in central nervous system (HP:0002529)1.92803435
97Heterotopia (HP:0002282)1.92160503
98Sleep apnea (HP:0010535)1.91870577
99Annular pancreas (HP:0001734)1.89657150
100Shawl scrotum (HP:0000049)1.87776132
101Impaired vibratory sensation (HP:0002495)1.87471464
102Craniofacial dystonia (HP:0012179)1.86822445
103Cutaneous syndactyly (HP:0012725)1.85948527
104Central scotoma (HP:0000603)1.84817755
105Apathy (HP:0000741)1.83052413
106Gait ataxia (HP:0002066)1.82345828
107Tetraplegia (HP:0002445)1.81960105
108Postural tremor (HP:0002174)1.81875030
109Overriding aorta (HP:0002623)1.81303996
110Abnormal EKG (HP:0003115)1.78978947
111Obstructive sleep apnea (HP:0002870)1.78871006
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77564066
113Hypoplasia of the brainstem (HP:0002365)1.77564066
114Protruding tongue (HP:0010808)1.77189839
115Morphological abnormality of the pyramidal tract (HP:0002062)1.76885687
116Urethral obstruction (HP:0000796)1.74111561
117Prolonged QT interval (HP:0001657)1.73878311
118Fetal akinesia sequence (HP:0001989)1.73809797
119Abnormality of the diencephalon (HP:0010662)1.73499317
120Obsessive-compulsive behavior (HP:0000722)1.73399198
121Autism (HP:0000717)1.72829815
122Akinesia (HP:0002304)1.72602714
123Bowel diverticulosis (HP:0005222)1.70793885
124Attention deficit hyperactivity disorder (HP:0007018)1.70359346
125Lower limb amyotrophy (HP:0007210)1.68938604
126Short 4th metacarpal (HP:0010044)1.68367619
127Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68367619
128Shallow orbits (HP:0000586)1.67025496
129Hypoventilation (HP:0002791)1.66175381
130Sporadic (HP:0003745)1.64055309
131Vertebral arch anomaly (HP:0008438)1.63401323
132Hypoplasia of the corpus callosum (HP:0002079)1.61929774
133Aplasia involving bones of the upper limbs (HP:0009823)1.61881959
134Aplasia of the phalanges of the hand (HP:0009802)1.61881959
135Aplasia involving bones of the extremities (HP:0009825)1.61881959
136Germ cell neoplasia (HP:0100728)1.61400117
137Generalized hypotonia (HP:0001290)1.60954253
138Sacral dimple (HP:0000960)1.60527586
139Megalocornea (HP:0000485)1.60136178
140Abnormality of the fingertips (HP:0001211)1.59692765
141Partial agenesis of the corpus callosum (HP:0001338)1.59312877
142Abnormality of the intervertebral disk (HP:0005108)1.57535956
143Long eyelashes (HP:0000527)1.56725731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.46119548
2NTRK34.37998533
3MAP3K94.11672909
4EPHA43.29072470
5MAP3K42.83374309
6NTRK22.67035453
7MINK12.59657326
8CDK122.49159839
9DAPK22.48589050
10PAK62.45573009
11TRIB32.43830961
12MAP2K72.04176998
13CAMK1D1.93764474
14PRKD31.93614985
15SIK21.93488911
16CAMKK11.93249936
17KSR11.77559928
18KSR21.75796609
19TYRO31.70269603
20TNIK1.68280326
21EEF2K1.63312450
22NTRK11.63245927
23BRD41.62065194
24MAP2K41.59031693
25CDK51.56355113
26UHMK11.56061062
27MAPK131.55839508
28PNCK1.45191713
29MAP3K101.40947050
30SIK11.36646708
31DAPK11.32777985
32STK381.32008974
33CAMKK21.21737738
34FGFR41.18485125
35RIPK11.15209785
36PRPF4B1.13524762
37MTOR1.11616540
38PRKCG1.09745008
39RIPK41.08736690
40CDK191.06327452
41PHKG21.04222066
42PHKG11.04222066
43ALK1.03197435
44MAP3K21.02199649
45GRK51.02144254
46TAOK11.01883546
47CAMK1G1.01653089
48SGK2230.99447946
49SGK4940.99447946
50SMG10.99029764
51STK110.98667254
52RET0.97797412
53ICK0.95776945
54MAP3K120.95256776
55MARK20.95163473
56PRKCH0.94335485
57PKN20.93977098
58CDK180.90638503
59FGFR20.90459088
60CDC42BPA0.90369938
61CDK150.89221394
62FES0.88927705
63PAK30.87591645
64WNK30.83573202
65DYRK1A0.82875755
66ERBB30.81555559
67CAMK10.81424739
68CDK140.80696215
69CSNK1G20.78253630
70CDK11A0.77210141
71PLK20.77156894
72CASK0.76026349
73SGK20.71532446
74CAMK2A0.71422368
75SGK10.69431375
76SGK30.68449327
77PDGFRA0.68076282
78WNK10.67013328
79LATS10.66021016
80PRKAA10.64795399
81LATS20.62567848
82PRKCZ0.62252924
83DYRK1B0.62196613
84CAMK2B0.61417764
85CSNK1E0.60494905
86SCYL20.57689683
87RPS6KA30.56570717
88CAMK40.55927005
89RPS6KA20.55381224
90DYRK20.52580629
91HIPK20.52365434
92INSRR0.52166540
93MAPK100.51751955
94EPHB20.51297002
95CDK10.50646313
96IRAK20.50096733
97FYN0.49797444
98CDK20.48847423
99ERBB20.48664261
100CDC70.48532910
101BCR0.47736812
102NEK20.47270370
103NEK60.45410995
104SIK30.44977255
105PINK10.43115322
106CSNK1A1L0.41822117
107PKN10.41797401
108PRKDC0.41752033
109NEK10.41151324
110BRAF0.40941462
111MAP3K130.40861154
112CSNK1D0.40120583
113MAPK140.39569565
114RAF10.38299218
115BRSK10.37092724
116RPS6KB10.37069633
117PDK10.37055019
118MAPK80.37033138
119PDPK10.36929862
120PRKCB0.36815750
121MAPK90.36166415
122WNK40.36114126
123AKT30.35836741
124LMTK20.35498111
125MAP3K10.35239734
126PTK20.35172096
127CSNK1G30.35125018
128FER0.35044458
129GSK3B0.34632216
130ARAF0.34206095
131RPS6KA10.33892890
132CHEK10.31078442

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55779458
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07859571
3GABAergic synapse_Homo sapiens_hsa047272.69980109
4Circadian entrainment_Homo sapiens_hsa047132.69931086
5Glutamatergic synapse_Homo sapiens_hsa047242.60613382
6Olfactory transduction_Homo sapiens_hsa047402.52674144
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52410793
8Long-term potentiation_Homo sapiens_hsa047202.47596307
9Morphine addiction_Homo sapiens_hsa050322.41389804
10Amphetamine addiction_Homo sapiens_hsa050312.27634867
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21765938
12Dopaminergic synapse_Homo sapiens_hsa047282.18563912
13Insulin secretion_Homo sapiens_hsa049112.18280126
14Cholinergic synapse_Homo sapiens_hsa047251.96571004
15Salivary secretion_Homo sapiens_hsa049701.95813721
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84522307
17Cocaine addiction_Homo sapiens_hsa050301.82247029
18Taste transduction_Homo sapiens_hsa047421.76728135
19Gastric acid secretion_Homo sapiens_hsa049711.72627769
20Type II diabetes mellitus_Homo sapiens_hsa049301.71768201
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70348933
22Long-term depression_Homo sapiens_hsa047301.69834424
23Oxytocin signaling pathway_Homo sapiens_hsa049211.59514613
24Notch signaling pathway_Homo sapiens_hsa043301.56177975
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54692895
26Serotonergic synapse_Homo sapiens_hsa047261.54626671
27Renin secretion_Homo sapiens_hsa049241.50993310
28Lysine degradation_Homo sapiens_hsa003101.48859442
29Gap junction_Homo sapiens_hsa045401.43529069
30GnRH signaling pathway_Homo sapiens_hsa049121.41645299
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40409485
32Calcium signaling pathway_Homo sapiens_hsa040201.37799933
33Axon guidance_Homo sapiens_hsa043601.34694124
34Phototransduction_Homo sapiens_hsa047441.31831604
35cAMP signaling pathway_Homo sapiens_hsa040241.26036619
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24424595
37Estrogen signaling pathway_Homo sapiens_hsa049151.24211334
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24157407
39Basal cell carcinoma_Homo sapiens_hsa052171.22633060
40Hippo signaling pathway_Homo sapiens_hsa043901.20314252
41Glioma_Homo sapiens_hsa052141.14255847
42ErbB signaling pathway_Homo sapiens_hsa040121.12455830
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08128585
44mRNA surveillance pathway_Homo sapiens_hsa030151.04571408
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02352005
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01795749
47Melanogenesis_Homo sapiens_hsa049161.01764076
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95985897
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95092423
50Pancreatic secretion_Homo sapiens_hsa049720.92839506
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.92469528
52Oocyte meiosis_Homo sapiens_hsa041140.89084974
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.85095351
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85026764
55Collecting duct acid secretion_Homo sapiens_hsa049660.84365788
56mTOR signaling pathway_Homo sapiens_hsa041500.83713670
57Thyroid hormone synthesis_Homo sapiens_hsa049180.81826915
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.80690053
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80626151
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79617576
61Dorso-ventral axis formation_Homo sapiens_hsa043200.78949610
62Choline metabolism in cancer_Homo sapiens_hsa052310.77707336
63Cardiac muscle contraction_Homo sapiens_hsa042600.76678971
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76149779
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75957996
66MAPK signaling pathway_Homo sapiens_hsa040100.75181370
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74731818
68Alcoholism_Homo sapiens_hsa050340.74154781
69Tight junction_Homo sapiens_hsa045300.73771292
70VEGF signaling pathway_Homo sapiens_hsa043700.73684580
71Dilated cardiomyopathy_Homo sapiens_hsa054140.73642259
72Endometrial cancer_Homo sapiens_hsa052130.73541036
73Nitrogen metabolism_Homo sapiens_hsa009100.73462988
74Vibrio cholerae infection_Homo sapiens_hsa051100.73131149
75Circadian rhythm_Homo sapiens_hsa047100.72151063
76Adherens junction_Homo sapiens_hsa045200.71908361
77Chronic myeloid leukemia_Homo sapiens_hsa052200.71871704
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71190471
79MicroRNAs in cancer_Homo sapiens_hsa052060.68702820
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65993729
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64263090
82Inositol phosphate metabolism_Homo sapiens_hsa005620.63135830
83Type I diabetes mellitus_Homo sapiens_hsa049400.61905774
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61749772
85Fatty acid biosynthesis_Homo sapiens_hsa000610.59925207
86Non-small cell lung cancer_Homo sapiens_hsa052230.58254200
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57298621
88Renal cell carcinoma_Homo sapiens_hsa052110.57159538
89Glucagon signaling pathway_Homo sapiens_hsa049220.56878292
90Vitamin B6 metabolism_Homo sapiens_hsa007500.55490007
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55030660
92Rap1 signaling pathway_Homo sapiens_hsa040150.54829146
93Insulin signaling pathway_Homo sapiens_hsa049100.54092488
94Endocytosis_Homo sapiens_hsa041440.52807834
95Ras signaling pathway_Homo sapiens_hsa040140.52426743
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51614388
97Wnt signaling pathway_Homo sapiens_hsa043100.51572046
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51311960
99Colorectal cancer_Homo sapiens_hsa052100.50827749
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.50321305
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.49872091
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48588979
103Bile secretion_Homo sapiens_hsa049760.47895164
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43841677
105Chemokine signaling pathway_Homo sapiens_hsa040620.38059191
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37673915
107Prion diseases_Homo sapiens_hsa050200.36840672
108Prolactin signaling pathway_Homo sapiens_hsa049170.36795533
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36669307
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.34800573
111Ovarian steroidogenesis_Homo sapiens_hsa049130.33829931
112Hedgehog signaling pathway_Homo sapiens_hsa043400.33217270
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.32099549
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30772835
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29376808
116AMPK signaling pathway_Homo sapiens_hsa041520.29371354

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