

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | type B pancreatic cell proliferation (GO:0044342) | 7.10650961 |
| 2 | collagen fibril organization (GO:0030199) | 6.61676222 |
| 3 | chondrocyte proliferation (GO:0035988) | 6.41947565 |
| 4 | sequestering of extracellular ligand from receptor (GO:0035581) | 6.33018784 |
| 5 | bone trabecula formation (GO:0060346) | 5.77688368 |
| 6 | endodermal cell differentiation (GO:0035987) | 5.39293840 |
| 7 | cell migration involved in heart development (GO:0060973) | 5.22935815 |
| 8 | protein heterotrimerization (GO:0070208) | 5.06145264 |
| 9 | cell adhesion mediated by integrin (GO:0033627) | 5.02872094 |
| 10 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 4.98392821 |
| 11 | axon extension involved in axon guidance (GO:0048846) | 4.98392821 |
| 12 | blood vessel maturation (GO:0001955) | 4.71187678 |
| 13 | negative regulation of fatty acid transport (GO:2000192) | 4.65421267 |
| 14 | positive regulation of fibroblast migration (GO:0010763) | 4.65407172 |
| 15 | endocardial cushion development (GO:0003197) | 4.48671776 |
| 16 | adhesion of symbiont to host cell (GO:0044650) | 4.44780184 |
| 17 | virion attachment to host cell (GO:0019062) | 4.44780184 |
| 18 | skin morphogenesis (GO:0043589) | 4.44653873 |
| 19 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 4.24881049 |
| 20 | collagen metabolic process (GO:0032963) | 4.02865012 |
| 21 | collagen catabolic process (GO:0030574) | 4.02862701 |
| 22 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 4.00187921 |
| 23 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.92137507 |
| 24 | fibril organization (GO:0097435) | 3.88817165 |
| 25 | pericardium development (GO:0060039) | 3.88220256 |
| 26 | epoxygenase P450 pathway (GO:0019373) | 3.87264693 |
| 27 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.79715919 |
| 28 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.78155272 |
| 29 | adhesion of symbiont to host (GO:0044406) | 3.73909100 |
| 30 | wound healing, spreading of epidermal cells (GO:0035313) | 3.73085008 |
| 31 | plasma membrane repair (GO:0001778) | 3.71771544 |
| 32 | craniofacial suture morphogenesis (GO:0097094) | 3.70911072 |
| 33 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.67027569 |
| 34 | multicellular organismal catabolic process (GO:0044243) | 3.66669619 |
| 35 | polarized epithelial cell differentiation (GO:0030859) | 3.62321862 |
| 36 | cellular response to vitamin D (GO:0071305) | 3.61223977 |
| 37 | kidney mesenchyme development (GO:0072074) | 3.58567597 |
| 38 | negative regulation of focal adhesion assembly (GO:0051895) | 3.57152969 |
| 39 | negative regulation of cell junction assembly (GO:1901889) | 3.57152969 |
| 40 | negative regulation of adherens junction organization (GO:1903392) | 3.57152969 |
| 41 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 3.54626873 |
| 42 | multicellular organismal metabolic process (GO:0044236) | 3.53421366 |
| 43 | chondrocyte development (GO:0002063) | 3.53143379 |
| 44 | extracellular matrix disassembly (GO:0022617) | 3.52687223 |
| 45 | basement membrane organization (GO:0071711) | 3.48589347 |
| 46 | venous blood vessel morphogenesis (GO:0048845) | 3.47936813 |
| 47 | epithelial cell-cell adhesion (GO:0090136) | 3.45730500 |
| 48 | extracellular regulation of signal transduction (GO:1900115) | 3.43971074 |
| 49 | extracellular negative regulation of signal transduction (GO:1900116) | 3.43971074 |
| 50 | cellular response to vitamin (GO:0071295) | 3.43543004 |
| 51 | peptidyl-proline hydroxylation (GO:0019511) | 3.41867036 |
| 52 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.40859627 |
| 53 | regulation of extracellular matrix disassembly (GO:0010715) | 3.39498310 |
| 54 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 3.38346718 |
| 55 | dermatan sulfate biosynthetic process (GO:0030208) | 3.33530137 |
| 56 | middle ear morphogenesis (GO:0042474) | 3.32350218 |
| 57 | metanephric mesenchyme development (GO:0072075) | 3.30995635 |
| 58 | negative regulation of leukocyte chemotaxis (GO:0002689) | 3.29213429 |
| 59 | substrate-dependent cell migration (GO:0006929) | 3.29153037 |
| 60 | omega-hydroxylase P450 pathway (GO:0097267) | 3.24512074 |
| 61 | regulation of integrin-mediated signaling pathway (GO:2001044) | 3.24017608 |
| 62 | negative chemotaxis (GO:0050919) | 3.23470036 |
| 63 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.22129589 |
| 64 | protein localization to cell surface (GO:0034394) | 3.21419020 |
| 65 | extracellular matrix assembly (GO:0085029) | 3.20673105 |
| 66 | negative regulation of chondrocyte differentiation (GO:0032331) | 3.19231146 |
| 67 | protein retention in ER lumen (GO:0006621) | 3.19169894 |
| 68 | endothelial cell morphogenesis (GO:0001886) | 3.16171568 |
| 69 | negative regulation of bone remodeling (GO:0046851) | 3.15672728 |
| 70 | embryonic skeletal joint morphogenesis (GO:0060272) | 3.15290998 |
| 71 | barbed-end actin filament capping (GO:0051016) | 3.14583113 |
| 72 | smooth muscle tissue development (GO:0048745) | 3.12928145 |
| 73 | negative regulation of osteoblast proliferation (GO:0033689) | 3.10701707 |
| 74 | response to magnesium ion (GO:0032026) | 3.10544394 |
| 75 | wound healing, spreading of cells (GO:0044319) | 3.10100078 |
| 76 | keratan sulfate catabolic process (GO:0042340) | 3.08904737 |
| 77 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.07863116 |
| 78 | dermatan sulfate metabolic process (GO:0030205) | 3.07506798 |
| 79 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 3.05789406 |
| 80 | hippo signaling (GO:0035329) | 3.05685926 |
| 81 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 3.05359207 |
| 82 | negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037) | 3.02022197 |
| 83 | hypotonic response (GO:0006971) | 3.01417347 |
| 84 | apoptotic cell clearance (GO:0043277) | 2.96298689 |
| 85 | stress fiber assembly (GO:0043149) | 2.95250284 |
| 86 | negative regulation of embryonic development (GO:0045992) | 2.94312293 |
| 87 | cell proliferation involved in metanephros development (GO:0072203) | 2.92186348 |
| 88 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.91896682 |
| 89 | negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394) | 2.91807393 |
| 90 | extracellular matrix organization (GO:0030198) | 2.91280680 |
| 91 | COPI coating of Golgi vesicle (GO:0048205) | 2.90159039 |
| 92 | Golgi transport vesicle coating (GO:0048200) | 2.90159039 |
| 93 | extracellular structure organization (GO:0043062) | 2.90099817 |
| 94 | negative regulation of BMP signaling pathway (GO:0030514) | 2.90062870 |
| 95 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.90054477 |
| 96 | response to follicle-stimulating hormone (GO:0032354) | 2.85701551 |
| 97 | positive regulation of macrophage activation (GO:0043032) | 2.85589117 |
| 98 | protein hydroxylation (GO:0018126) | 2.83453241 |
| 99 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.83373383 |
| 100 | cell-substrate junction assembly (GO:0007044) | 2.83073751 |
| 101 | regulation of smooth muscle cell migration (GO:0014910) | 2.80152744 |
| 102 | positive regulation of extracellular matrix organization (GO:1903055) | 2.79989920 |
| 103 | regulation of transforming growth factor beta1 production (GO:0032908) | 2.79954452 |
| 104 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.78993427 |
| 105 | cellular response to amino acid stimulus (GO:0071230) | 2.78253464 |
| 106 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 2.77493559 |
| 107 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 2.77083699 |
| 108 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.76486210 |
| 109 | cranial suture morphogenesis (GO:0060363) | 2.76144523 |
| 110 | regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358) | 2.75005880 |
| 111 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.74901459 |
| 112 | extracellular fibril organization (GO:0043206) | 2.74434162 |
| 113 | negative regulation of catenin import into nucleus (GO:0035414) | 2.73150260 |
| 114 | positive regulation of osteoblast proliferation (GO:0033690) | 2.72763802 |
| 115 | positive regulation of cartilage development (GO:0061036) | 2.72622126 |
| 116 | glomerular basement membrane development (GO:0032836) | 2.72100757 |
| 117 | positive regulation of gastrulation (GO:2000543) | 2.71057855 |
| 118 | axon extension (GO:0048675) | 2.69968009 |
| 119 | regulation of collagen metabolic process (GO:0010712) | 2.68808187 |
| 120 | tooth mineralization (GO:0034505) | 2.68431687 |
| 121 | negative regulation of fibrinolysis (GO:0051918) | 2.68307694 |
| 122 | trabecula formation (GO:0060343) | 2.68190763 |
| 123 | camera-type eye morphogenesis (GO:0048593) | 2.65658886 |
| 124 | cell migration involved in sprouting angiogenesis (GO:0002042) | 2.65057029 |
| 125 | cellular response to interferon-alpha (GO:0035457) | 2.65054944 |
| 126 | negative regulation of cell-matrix adhesion (GO:0001953) | 2.63195553 |
| 127 | heparan sulfate proteoglycan metabolic process (GO:0030201) | 2.60673200 |
| 128 | regulation of plasminogen activation (GO:0010755) | 2.60300064 |
| 129 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.59595645 |
| 130 | replacement ossification (GO:0036075) | 2.59584376 |
| 131 | endochondral ossification (GO:0001958) | 2.59584376 |
| 132 | negative regulation of cartilage development (GO:0061037) | 2.57462737 |
| 133 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.56702425 |
| 134 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.56220105 |
| 135 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.54906618 |
| 136 | response to fluid shear stress (GO:0034405) | 2.54352535 |
| 137 | regulation of establishment of planar polarity (GO:0090175) | 2.51727969 |
| 138 | adherens junction assembly (GO:0034333) | 2.50224909 |
| 139 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.48182301 |
| 140 | regulation of chemokine-mediated signaling pathway (GO:0070099) | 2.47832039 |
| 141 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.46194382 |
| 142 | regulation of tight junction assembly (GO:2000810) | 2.43771533 |
| 143 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.42261919 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 5.87792998 |
| 2 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.34607313 |
| 3 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.99148964 |
| 4 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.71426978 |
| 5 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.64145691 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.33432297 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.33432297 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.29866322 |
| 9 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.27936816 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.19674417 |
| 11 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 2.18730966 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.14191871 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.03895127 |
| 14 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.03615828 |
| 15 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.01922657 |
| 16 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 2.01723456 |
| 17 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.01375825 |
| 18 | CJUN_26792858_Chip-Seq_BT549_Human | 1.95109055 |
| 19 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.93790279 |
| 20 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.92664383 |
| 21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.91901056 |
| 22 | TP53_16413492_ChIP-PET_HCT116_Human | 1.86758816 |
| 23 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.86135121 |
| 24 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.85193595 |
| 25 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.84403023 |
| 26 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.84251271 |
| 27 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.83915613 |
| 28 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.83433707 |
| 29 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.83433707 |
| 30 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.82857576 |
| 31 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.80801995 |
| 32 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.78194501 |
| 33 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.77608730 |
| 34 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.77095917 |
| 35 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.74949778 |
| 36 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.69802661 |
| 37 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.66459365 |
| 38 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.65439111 |
| 39 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.63771276 |
| 40 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.62461304 |
| 41 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.60860098 |
| 42 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.59435091 |
| 43 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.58447638 |
| 44 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.52447165 |
| 45 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.51945648 |
| 46 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.51894450 |
| 47 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.51499141 |
| 48 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.49641038 |
| 49 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.46420244 |
| 50 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.40766889 |
| 51 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.38577599 |
| 52 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.38189760 |
| 53 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.34395581 |
| 54 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.33323629 |
| 55 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.31292012 |
| 56 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.28841368 |
| 57 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.28594812 |
| 58 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27347906 |
| 59 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.27175153 |
| 60 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.26669105 |
| 61 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.24649841 |
| 62 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.23126812 |
| 63 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.22855476 |
| 64 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.21427833 |
| 65 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.20054871 |
| 66 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.20045934 |
| 67 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.20041880 |
| 68 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.19188254 |
| 69 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.18281503 |
| 70 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.16585445 |
| 71 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.15961265 |
| 72 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.15396171 |
| 73 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.15274720 |
| 74 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.14305067 |
| 75 | RXR_22108803_ChIP-Seq_LS180_Human | 1.14228464 |
| 76 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.13665927 |
| 77 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.12725925 |
| 78 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.12560165 |
| 79 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.11934942 |
| 80 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.11877432 |
| 81 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.11423346 |
| 82 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.10635656 |
| 83 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.09913556 |
| 84 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.09466882 |
| 85 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.09466882 |
| 86 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.09154416 |
| 87 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.09123289 |
| 88 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.08145275 |
| 89 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.06570317 |
| 90 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.06287362 |
| 91 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.06199557 |
| 92 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.06192336 |
| 93 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.06105650 |
| 94 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.05969708 |
| 95 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.05794378 |
| 96 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.05432249 |
| 97 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.05313371 |
| 98 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.04799546 |
| 99 | KDM2B_26808549_Chip-Seq_K562_Human | 1.04199774 |
| 100 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.03900677 |
| 101 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.02906517 |
| 102 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.01972781 |
| 103 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.00709062 |
| 104 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.99546511 |
| 105 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.99410004 |
| 106 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.98747606 |
| 107 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.98747606 |
| 108 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.98434074 |
| 109 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.98405077 |
| 110 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.97459869 |
| 111 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.95831117 |
| 112 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.95371863 |
| 113 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.94609850 |
| 114 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.94331274 |
| 115 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.94198083 |
| 116 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.92795745 |
| 117 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.92615030 |
| 118 | AR_19668381_ChIP-Seq_PC3_Human | 0.92396591 |
| 119 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 0.91752067 |
| 120 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.90916645 |
| 121 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.90914344 |
| 122 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.90767599 |
| 123 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.90685826 |
| 124 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90041396 |
| 125 | KLF5_25053715_ChIP-Seq_YYC3_Human | 0.89862735 |
| 126 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.89692645 |
| 127 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.88928607 |
| 128 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.88899165 |
| 129 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.88290747 |
| 130 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.88008468 |
| 131 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.85890014 |
| 132 | PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human | 0.84817863 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 8.26847823 |
| 2 | MP0005275_abnormal_skin_tensile | 5.16001879 |
| 3 | MP0005503_abnormal_tendon_morphology | 4.95477591 |
| 4 | MP0003279_aneurysm | 4.03740267 |
| 5 | MP0005623_abnormal_meninges_morphology | 3.85538924 |
| 6 | MP0003705_abnormal_hypodermis_morpholog | 3.70128666 |
| 7 | MP0009384_cardiac_valve_regurgitation | 3.37474396 |
| 8 | MP0001958_emphysema | 3.06618373 |
| 9 | MP0004272_abnormal_basement_membrane | 2.73364648 |
| 10 | MP0005257_abnormal_intraocular_pressure | 2.67238857 |
| 11 | MP0010352_gastrointestinal_tract_polyps | 2.36119537 |
| 12 | MP0002295_abnormal_pulmonary_circulatio | 2.31022034 |
| 13 | MP0001348_abnormal_lacrimal_gland | 2.20510117 |
| 14 | MP0005508_abnormal_skeleton_morphology | 2.17259895 |
| 15 | MP0003566_abnormal_cell_adhesion | 2.12389727 |
| 16 | MP0006054_spinal_hemorrhage | 2.02359047 |
| 17 | MP0003283_abnormal_digestive_organ | 1.98749901 |
| 18 | MP0003091_abnormal_cell_migration | 1.97644911 |
| 19 | MP0010368_abnormal_lymphatic_system | 1.90205676 |
| 20 | MP0003385_abnormal_body_wall | 1.89557158 |
| 21 | MP0001299_abnormal_eye_distance/ | 1.79324854 |
| 22 | MP0009250_abnormal_appendicular_skeleto | 1.74606455 |
| 23 | MP0005023_abnormal_wound_healing | 1.68691086 |
| 24 | MP0002060_abnormal_skin_morphology | 1.66484307 |
| 25 | MP0003941_abnormal_skin_development | 1.65438318 |
| 26 | MP0003950_abnormal_plasma_membrane | 1.65075926 |
| 27 | MP0009780_abnormal_chondrocyte_physiolo | 1.62790159 |
| 28 | MP0000013_abnormal_adipose_tissue | 1.58753180 |
| 29 | MP0004859_abnormal_synaptic_plasticity | 1.58751953 |
| 30 | MP0001542_abnormal_bone_strength | 1.57835565 |
| 31 | MP0002896_abnormal_bone_mineralization | 1.56360653 |
| 32 | MP0004134_abnormal_chest_morphology | 1.44953567 |
| 33 | MP0002108_abnormal_muscle_morphology | 1.44227490 |
| 34 | MP0010386_abnormal_urinary_bladder | 1.41946116 |
| 35 | MP0000534_abnormal_ureter_morphology | 1.41140896 |
| 36 | MP0000767_abnormal_smooth_muscle | 1.35932058 |
| 37 | MP0003942_abnormal_urinary_system | 1.32349471 |
| 38 | MP0003045_fibrosis | 1.28474685 |
| 39 | MP0001243_abnormal_dermal_layer | 1.22695252 |
| 40 | MP0000733_abnormal_muscle_development | 1.22678663 |
| 41 | MP0004858_abnormal_nervous_system | 1.22440052 |
| 42 | MP0002089_abnormal_postnatal_growth/wei | 1.17265047 |
| 43 | MP0003115_abnormal_respiratory_system | 1.16963726 |
| 44 | MP0002282_abnormal_trachea_morphology | 1.15769768 |
| 45 | MP0005390_skeleton_phenotype | 1.15645396 |
| 46 | MP0000428_abnormal_craniofacial_morphol | 1.13865035 |
| 47 | MP0002932_abnormal_joint_morphology | 1.13256297 |
| 48 | MP0002115_abnormal_skeleton_extremities | 1.12699231 |
| 49 | MP0000163_abnormal_cartilage_morphology | 1.11384859 |
| 50 | MP0009053_abnormal_anal_canal | 1.10270639 |
| 51 | MP0003755_abnormal_palate_morphology | 1.09894798 |
| 52 | MP0005171_absent_coat_pigmentation | 1.06712580 |
| 53 | MP0002168_other_aberrant_phenotype | 1.05027768 |
| 54 | MP0001177_atelectasis | 0.99925597 |
| 55 | MP0010030_abnormal_orbit_morphology | 0.97540742 |
| 56 | MP0002113_abnormal_skeleton_development | 0.96921324 |
| 57 | MP0002233_abnormal_nose_morphology | 0.94356658 |
| 58 | MP0002998_abnormal_bone_remodeling | 0.91525634 |
| 59 | MP0002933_joint_inflammation | 0.88461970 |
| 60 | MP0000432_abnormal_head_morphology | 0.87270710 |
| 61 | MP0002116_abnormal_craniofacial_bone | 0.87089630 |
| 62 | MP0002254_reproductive_system_inflammat | 0.85527827 |
| 63 | MP0002877_abnormal_melanocyte_morpholog | 0.84786944 |
| 64 | MP0005076_abnormal_cell_differentiation | 0.82377970 |
| 65 | MP0000049_abnormal_middle_ear | 0.82047656 |
| 66 | MP0003935_abnormal_craniofacial_develop | 0.79825126 |
| 67 | MP0001849_ear_inflammation | 0.79424149 |
| 68 | MP0000003_abnormal_adipose_tissue | 0.77830505 |
| 69 | MP0002109_abnormal_limb_morphology | 0.77253236 |
| 70 | MP0000569_abnormal_digit_pigmentation | 0.75494611 |
| 71 | MP0002697_abnormal_eye_size | 0.74458489 |
| 72 | MP0002128_abnormal_blood_circulation | 0.72785080 |
| 73 | MP0005595_abnormal_vascular_smooth | 0.71700262 |
| 74 | MP0002133_abnormal_respiratory_system | 0.71600270 |
| 75 | MP0005388_respiratory_system_phenotype | 0.71600270 |
| 76 | MP0000467_abnormal_esophagus_morphology | 0.70302188 |
| 77 | MP0000538_abnormal_urinary_bladder | 0.68989921 |
| 78 | MP0002111_abnormal_tail_morphology | 0.68703460 |
| 79 | MP0005197_abnormal_uvea_morphology | 0.68607151 |
| 80 | MP0006138_congestive_heart_failure | 0.68479746 |
| 81 | MP0002177_abnormal_outer_ear | 0.67299524 |
| 82 | MP0002114_abnormal_axial_skeleton | 0.66983719 |
| 83 | MP0001879_abnormal_lymphatic_vessel | 0.66630163 |
| 84 | MP0003795_abnormal_bone_structure | 0.66259424 |
| 85 | MP0000751_myopathy | 0.66202768 |
| 86 | MP0003937_abnormal_limbs/digits/tail_de | 0.65896444 |
| 87 | MP0001614_abnormal_blood_vessel | 0.65022162 |
| 88 | MP0004233_abnormal_muscle_weight | 0.64773438 |
| 89 | MP0000516_abnormal_urinary_system | 0.63740684 |
| 90 | MP0005367_renal/urinary_system_phenotyp | 0.63740684 |
| 91 | MP0000762_abnormal_tongue_morphology | 0.62445909 |
| 92 | MP0005193_abnormal_anterior_eye | 0.62174003 |
| 93 | MP0005164_abnormal_response_to | 0.62046005 |
| 94 | MP0008004_abnormal_stomach_pH | 0.61224876 |
| 95 | MP0009840_abnormal_foam_cell | 0.60540963 |
| 96 | MP0003329_amyloid_beta_deposits | 0.60487084 |
| 97 | MP0000749_muscle_degeneration | 0.59849221 |
| 98 | MP0005058_abnormal_lysosome_morphology | 0.59744872 |
| 99 | MP0002249_abnormal_larynx_morphology | 0.59559280 |
| 100 | MP0004883_abnormal_blood_vessel | 0.59027007 |
| 101 | MP0003300_gastrointestinal_ulcer | 0.57714803 |
| 102 | MP0001533_abnormal_skeleton_physiology | 0.57456738 |
| 103 | MP0003448_altered_tumor_morphology | 0.56565065 |
| 104 | MP0001915_intracranial_hemorrhage | 0.55715684 |
| 105 | MP0000462_abnormal_digestive_system | 0.55176657 |
| 106 | MP0000750_abnormal_muscle_regeneration | 0.54984588 |
| 107 | MP0005084_abnormal_gallbladder_morpholo | 0.54026172 |
| 108 | MP0001340_abnormal_eyelid_morphology | 0.53878446 |
| 109 | MP0002925_abnormal_cardiovascular_devel | 0.53354805 |
| 110 | MP0001270_distended_abdomen | 0.53169119 |
| 111 | MP0001175_abnormal_lung_morphology | 0.52987554 |
| 112 | MP0002928_abnormal_bile_duct | 0.52255515 |
| 113 | MP0010771_integument_phenotype | 0.50417432 |
| 114 | MP0000759_abnormal_skeletal_muscle | 0.50069415 |
| 115 | MP0000681_abnormal_thyroid_gland | 0.44140238 |
| 116 | MP0005165_increased_susceptibility_to | 0.43662276 |
| 117 | MP0000343_altered_response_to | 0.42883791 |
| 118 | MP0005369_muscle_phenotype | 0.42023479 |
| 119 | MP0003191_abnormal_cellular_cholesterol | 0.39729003 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Premature rupture of membranes (HP:0001788) | 8.69431632 |
| 2 | Protrusio acetabuli (HP:0003179) | 8.56807360 |
| 3 | Shallow orbits (HP:0000586) | 5.37122498 |
| 4 | Peritonitis (HP:0002586) | 5.30208554 |
| 5 | Aortic dissection (HP:0002647) | 5.13016951 |
| 6 | Atrophic scars (HP:0001075) | 4.89467199 |
| 7 | Abnormality of dentin (HP:0010299) | 4.57254946 |
| 8 | Soft skin (HP:0000977) | 4.48407256 |
| 9 | Bladder diverticulum (HP:0000015) | 4.30126310 |
| 10 | Genu recurvatum (HP:0002816) | 4.20186161 |
| 11 | Fragile skin (HP:0001030) | 4.17531655 |
| 12 | Broad metatarsal (HP:0001783) | 4.00991459 |
| 13 | Neonatal short-limb short stature (HP:0008921) | 3.98873900 |
| 14 | Dilatation of the ascending aorta (HP:0005111) | 3.98724299 |
| 15 | Cervical subluxation (HP:0003308) | 3.86005065 |
| 16 | Cerebral aneurysm (HP:0004944) | 3.76291067 |
| 17 | Aortic aneurysm (HP:0004942) | 3.75866955 |
| 18 | Ankle contracture (HP:0006466) | 3.69747702 |
| 19 | Slender build (HP:0001533) | 3.64139287 |
| 20 | Mitral valve prolapse (HP:0001634) | 3.53441204 |
| 21 | Blue sclerae (HP:0000592) | 3.42651368 |
| 22 | Wormian bones (HP:0002645) | 3.39675941 |
| 23 | Bowel diverticulosis (HP:0005222) | 3.35009781 |
| 24 | Biconcave vertebral bodies (HP:0004586) | 3.31508920 |
| 25 | Infantile muscular hypotonia (HP:0008947) | 3.25464003 |
| 26 | Hyperextensible skin (HP:0000974) | 3.07671233 |
| 27 | Vascular tortuosity (HP:0004948) | 2.99730170 |
| 28 | Wrist flexion contracture (HP:0001239) | 2.92311720 |
| 29 | Vertebral compression fractures (HP:0002953) | 2.91673018 |
| 30 | Ectopia lentis (HP:0001083) | 2.79957735 |
| 31 | Abnormal delivery (HP:0001787) | 2.78295592 |
| 32 | Buphthalmos (HP:0000557) | 2.74226763 |
| 33 | Overgrowth (HP:0001548) | 2.72905180 |
| 34 | Broad ribs (HP:0000885) | 2.59363410 |
| 35 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.58593304 |
| 36 | Aortic valve stenosis (HP:0001650) | 2.54162636 |
| 37 | Follicular hyperkeratosis (HP:0007502) | 2.52847263 |
| 38 | Deviation of the hallux (HP:0010051) | 2.52612167 |
| 39 | Hallux valgus (HP:0001822) | 2.48734218 |
| 40 | Hypoventilation (HP:0002791) | 2.47332786 |
| 41 | Congenital glaucoma (HP:0001087) | 2.46666094 |
| 42 | Wide anterior fontanel (HP:0000260) | 2.46136357 |
| 43 | Tibial bowing (HP:0002982) | 2.42066815 |
| 44 | Arterial tortuosity (HP:0005116) | 2.41438382 |
| 45 | Elbow flexion contracture (HP:0002987) | 2.39491041 |
| 46 | Abnormality of the acetabulum (HP:0003170) | 2.38703137 |
| 47 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.38264900 |
| 48 | Bell-shaped thorax (HP:0001591) | 2.37203522 |
| 49 | Morphological abnormality of the middle ear (HP:0008609) | 2.36243182 |
| 50 | Joint stiffness (HP:0001387) | 2.34951700 |
| 51 | Spinal rigidity (HP:0003306) | 2.34839633 |
| 52 | Mild short stature (HP:0003502) | 2.31940878 |
| 53 | Mesomelia (HP:0003027) | 2.31590282 |
| 54 | Abnormality of the peritoneum (HP:0002585) | 2.30825141 |
| 55 | Redundant skin (HP:0001582) | 2.30157722 |
| 56 | Camptodactyly of toe (HP:0001836) | 2.29988040 |
| 57 | Osteolytic defects of the hand bones (HP:0009699) | 2.26400187 |
| 58 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.26400187 |
| 59 | Breech presentation (HP:0001623) | 2.26144969 |
| 60 | Osteoarthritis (HP:0002758) | 2.25403036 |
| 61 | Aneurysm (HP:0002617) | 2.24552268 |
| 62 | Thin bony cortex (HP:0002753) | 2.23723395 |
| 63 | Joint laxity (HP:0001388) | 2.23490216 |
| 64 | Femoral bowing (HP:0002980) | 2.23314200 |
| 65 | Knee flexion contracture (HP:0006380) | 2.15946304 |
| 66 | Mitral regurgitation (HP:0001653) | 2.15605704 |
| 67 | Increased connective tissue (HP:0009025) | 2.14032779 |
| 68 | Delayed closure of the anterior fontanelle (HP:0001476) | 2.12302548 |
| 69 | Broad long bones (HP:0005622) | 2.10379586 |
| 70 | Ovoid vertebral bodies (HP:0003300) | 2.09686327 |
| 71 | Coronal craniosynostosis (HP:0004440) | 2.06381781 |
| 72 | Long toe (HP:0010511) | 2.04219739 |
| 73 | Round ear (HP:0100830) | 2.03483056 |
| 74 | Thoracolumbar scoliosis (HP:0002944) | 2.02920958 |
| 75 | Mitral stenosis (HP:0001718) | 2.02286557 |
| 76 | Type 1 muscle fiber predominance (HP:0003803) | 2.01798595 |
| 77 | Natal tooth (HP:0000695) | 2.01649962 |
| 78 | Spondylolisthesis (HP:0003302) | 2.01289601 |
| 79 | Renal duplication (HP:0000075) | 1.97956256 |
| 80 | Radial bowing (HP:0002986) | 1.95314901 |
| 81 | Upper limb amyotrophy (HP:0009129) | 1.94430700 |
| 82 | Distal upper limb amyotrophy (HP:0007149) | 1.94430700 |
| 83 | Flat cornea (HP:0007720) | 1.93705830 |
| 84 | Ulnar bowing (HP:0003031) | 1.92882578 |
| 85 | Flared iliac wings (HP:0002869) | 1.92454099 |
| 86 | Venous insufficiency (HP:0005293) | 1.91745868 |
| 87 | Emphysema (HP:0002097) | 1.91634928 |
| 88 | Delayed cranial suture closure (HP:0000270) | 1.91412224 |
| 89 | Coxa vara (HP:0002812) | 1.91093029 |
| 90 | Generalized amyotrophy (HP:0003700) | 1.90571433 |
| 91 | Protruding ear (HP:0000411) | 1.89934698 |
| 92 | Abnormality of the anterior chamber (HP:0000593) | 1.89825969 |
| 93 | Increased variability in muscle fiber diameter (HP:0003557) | 1.89248020 |
| 94 | Short nail (HP:0001799) | 1.88501350 |
| 95 | Absent frontal sinuses (HP:0002688) | 1.87050623 |
| 96 | Decreased skull ossification (HP:0004331) | 1.86738270 |
| 97 | Venous abnormality (HP:0002624) | 1.84819367 |
| 98 | Premature skin wrinkling (HP:0100678) | 1.84642722 |
| 99 | Spinal cord compression (HP:0002176) | 1.84129715 |
| 100 | Hip contracture (HP:0003273) | 1.83500613 |
| 101 | Sparse lateral eyebrow (HP:0005338) | 1.82601676 |
| 102 | Osteopenia (HP:0000938) | 1.81122025 |
| 103 | Hypoplasia of the iris (HP:0007676) | 1.79829057 |
| 104 | Nonimmune hydrops fetalis (HP:0001790) | 1.79036860 |
| 105 | Bowing of the arm (HP:0006488) | 1.78394375 |
| 106 | Bowed forearm bones (HP:0003956) | 1.78394375 |
| 107 | Inguinal hernia (HP:0000023) | 1.78094924 |
| 108 | Cardiovascular calcification (HP:0011915) | 1.77896927 |
| 109 | Deformed tarsal bones (HP:0008119) | 1.77728051 |
| 110 | Platyspondyly (HP:0000926) | 1.77408305 |
| 111 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.76585042 |
| 112 | Flexion contracture of toe (HP:0005830) | 1.74864648 |
| 113 | Joint contractures involving the joints of the feet (HP:0100492) | 1.74864648 |
| 114 | Limb-girdle muscle weakness (HP:0003325) | 1.74336537 |
| 115 | Hydroxyprolinuria (HP:0003080) | 1.73363148 |
| 116 | Abnormality of proline metabolism (HP:0010907) | 1.73363148 |
| 117 | Disproportionate tall stature (HP:0001519) | 1.73182797 |
| 118 | Persistence of primary teeth (HP:0006335) | 1.72178385 |
| 119 | Asymmetry of the thorax (HP:0001555) | 1.71242334 |
| 120 | Abnormality of skull ossification (HP:0002703) | 1.70164505 |
| 121 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.69130607 |
| 122 | Spinal cord lesions (HP:0100561) | 1.67977927 |
| 123 | Syringomyelia (HP:0003396) | 1.67977927 |
| 124 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.65849474 |
| 125 | Aplasia of the phalanges of the hand (HP:0009802) | 1.65849474 |
| 126 | Aplasia involving bones of the extremities (HP:0009825) | 1.65849474 |
| 127 | Microglossia (HP:0000171) | 1.65196193 |
| 128 | Cupped ribs (HP:0000887) | 1.64404763 |
| 129 | Narrow nasal bridge (HP:0000446) | 1.63463879 |
| 130 | Aortic regurgitation (HP:0001659) | 1.63376961 |
| 131 | Tarsal synostosis (HP:0008368) | 1.62903956 |
| 132 | Hypoplastic ischia (HP:0003175) | 1.62530381 |
| 133 | Turricephaly (HP:0000262) | 1.62326602 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DDR2 | 6.14171503 |
| 2 | PDGFRA | 3.72924106 |
| 3 | NEK9 | 3.61029518 |
| 4 | LATS2 | 3.52727452 |
| 5 | TTN | 3.25900143 |
| 6 | TRIB3 | 2.74431471 |
| 7 | LATS1 | 2.65618824 |
| 8 | PAK3 | 2.55169344 |
| 9 | EPHB2 | 2.33147141 |
| 10 | RIPK1 | 2.30069164 |
| 11 | PAK2 | 2.19932025 |
| 12 | TGFBR2 | 2.14533500 |
| 13 | KIT | 2.09161240 |
| 14 | AKT3 | 2.03459768 |
| 15 | NTRK1 | 1.82980070 |
| 16 | PTK2 | 1.77830423 |
| 17 | SIK1 | 1.65953752 |
| 18 | DMPK | 1.64575361 |
| 19 | FER | 1.63381466 |
| 20 | PKN2 | 1.60569631 |
| 21 | BMX | 1.58931833 |
| 22 | PTK2B | 1.54828539 |
| 23 | PAK6 | 1.51606803 |
| 24 | NTRK3 | 1.48289257 |
| 25 | PLK2 | 1.41620142 |
| 26 | ERN1 | 1.37941747 |
| 27 | TRPM7 | 1.31797717 |
| 28 | GRK5 | 1.29214661 |
| 29 | PDGFRB | 1.29081386 |
| 30 | EPHA3 | 1.27034053 |
| 31 | FLT3 | 1.25263022 |
| 32 | PRKD3 | 1.14058161 |
| 33 | GRK7 | 1.11755472 |
| 34 | PIK3CA | 1.10220873 |
| 35 | CAMKK1 | 1.09962718 |
| 36 | ROCK1 | 1.09505552 |
| 37 | MARK1 | 1.09124092 |
| 38 | MOS | 1.08804738 |
| 39 | TESK1 | 1.08720397 |
| 40 | FGFR1 | 1.05058352 |
| 41 | TAOK2 | 1.04621901 |
| 42 | MAP3K9 | 1.02959442 |
| 43 | PRKCH | 0.99997655 |
| 44 | MTOR | 0.97489428 |
| 45 | SCYL2 | 0.95009448 |
| 46 | PIM2 | 0.93953915 |
| 47 | DAPK3 | 0.89569201 |
| 48 | PIK3CG | 0.88843528 |
| 49 | MAP3K3 | 0.87096163 |
| 50 | MAP2K3 | 0.86480069 |
| 51 | EPHB1 | 0.84899719 |
| 52 | CDC42BPA | 0.84737607 |
| 53 | PTK6 | 0.84274000 |
| 54 | MET | 0.83916787 |
| 55 | MAP3K6 | 0.83901711 |
| 56 | TYK2 | 0.82690439 |
| 57 | FGFR4 | 0.82584592 |
| 58 | STK38 | 0.82215542 |
| 59 | FRK | 0.82186494 |
| 60 | ROCK2 | 0.81903135 |
| 61 | ADRBK2 | 0.81593597 |
| 62 | TAOK1 | 0.81226578 |
| 63 | MINK1 | 0.81219579 |
| 64 | TYRO3 | 0.81112566 |
| 65 | GRK1 | 0.81111089 |
| 66 | PRKG2 | 0.79163463 |
| 67 | DAPK2 | 0.78953264 |
| 68 | STK3 | 0.78387147 |
| 69 | ICK | 0.77996628 |
| 70 | RET | 0.77953080 |
| 71 | INSR | 0.76530610 |
| 72 | LIMK1 | 0.74041442 |
| 73 | KSR1 | 0.73925149 |
| 74 | PAK4 | 0.73687944 |
| 75 | CAMK1G | 0.73298804 |
| 76 | MAP2K1 | 0.72306055 |
| 77 | MYLK | 0.70762770 |
| 78 | CDK14 | 0.70707206 |
| 79 | DYRK1B | 0.69440565 |
| 80 | PRKD2 | 0.69133440 |
| 81 | CDK15 | 0.69011813 |
| 82 | LRRK2 | 0.68257716 |
| 83 | ERBB3 | 0.64472554 |
| 84 | CDK18 | 0.64244553 |
| 85 | CAMK2G | 0.61032621 |
| 86 | ERBB4 | 0.59583495 |
| 87 | RPS6KL1 | 0.59513955 |
| 88 | RPS6KC1 | 0.59513955 |
| 89 | SRC | 0.58646440 |
| 90 | MARK2 | 0.58540792 |
| 91 | MAP3K7 | 0.57365506 |
| 92 | CDK11A | 0.57317698 |
| 93 | JAK3 | 0.57200136 |
| 94 | ALK | 0.57064878 |
| 95 | PRKCE | 0.56780867 |
| 96 | ILK | 0.56764204 |
| 97 | ABL2 | 0.55502580 |
| 98 | KSR2 | 0.55119199 |
| 99 | GRK6 | 0.53387654 |
| 100 | EEF2K | 0.52316788 |
| 101 | FYN | 0.51768493 |
| 102 | FGFR2 | 0.50998987 |
| 103 | PRKD1 | 0.50425536 |
| 104 | WNK1 | 0.49459068 |
| 105 | GSK3A | 0.49239051 |
| 106 | PRKCG | 0.48646024 |
| 107 | MELK | 0.48423247 |
| 108 | ADRBK1 | 0.48080896 |
| 109 | CDK5 | 0.47953633 |
| 110 | EPHA4 | 0.47524157 |
| 111 | MAPK7 | 0.46960804 |
| 112 | JAK1 | 0.46670273 |
| 113 | PRPF4B | 0.46557386 |
| 114 | CAMKK2 | 0.45684221 |
| 115 | CDK8 | 0.45284294 |
| 116 | MAP3K10 | 0.44061200 |
| 117 | TBK1 | 0.43422229 |
| 118 | RPS6KA6 | 0.42643715 |
| 119 | LMTK2 | 0.42217351 |
| 120 | MAP3K12 | 0.41794348 |
| 121 | STK11 | 0.41339622 |
| 122 | RPS6KA2 | 0.41053195 |
| 123 | CDK6 | 0.40864296 |
| 124 | NUAK1 | 0.40281550 |
| 125 | NTRK2 | 0.39534650 |
| 126 | PAK1 | 0.38665244 |
| 127 | CASK | 0.38373939 |
| 128 | MAPKAPK5 | 0.37802714 |
| 129 | ARAF | 0.37325059 |
| 130 | PDK3 | 0.36430417 |
| 131 | ZAP70 | 0.36081273 |
| 132 | MAPKAPK3 | 0.35818709 |
| 133 | CLK1 | 0.34271088 |
| 134 | SMG1 | 0.32008197 |
| 135 | IRAK3 | 0.29831035 |
| 136 | HIPK2 | 0.29574658 |
| 137 | MAPKAPK2 | 0.29128175 |
| 138 | MAPK4 | 0.27257026 |
| 139 | PRKCD | 0.25054939 |
| 140 | ABL1 | 0.24805609 |
| 141 | CAMK2B | 0.23823083 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 3.77006137 |
| 2 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.70967500 |
| 3 | Focal adhesion_Homo sapiens_hsa04510 | 2.69848059 |
| 4 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.45487249 |
| 5 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 2.18887058 |
| 6 | Amoebiasis_Homo sapiens_hsa05146 | 2.18072849 |
| 7 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.97762483 |
| 8 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.96206995 |
| 9 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.88486717 |
| 10 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.88392251 |
| 11 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.87469045 |
| 12 | Bladder cancer_Homo sapiens_hsa05219 | 1.84406303 |
| 13 | Other glycan degradation_Homo sapiens_hsa00511 | 1.83791679 |
| 14 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.78118375 |
| 15 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.77878396 |
| 16 | Malaria_Homo sapiens_hsa05144 | 1.71276412 |
| 17 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.64938184 |
| 18 | Axon guidance_Homo sapiens_hsa04360 | 1.58730322 |
| 19 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.58099964 |
| 20 | Adherens junction_Homo sapiens_hsa04520 | 1.54561294 |
| 21 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.51246983 |
| 22 | Glioma_Homo sapiens_hsa05214 | 1.44052352 |
| 23 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.39978276 |
| 24 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.38695887 |
| 25 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.35824760 |
| 26 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.30648467 |
| 27 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.29489317 |
| 28 | Melanoma_Homo sapiens_hsa05218 | 1.27677433 |
| 29 | Melanogenesis_Homo sapiens_hsa04916 | 1.26023109 |
| 30 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.21734677 |
| 31 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.21529290 |
| 32 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.20763074 |
| 33 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.19793724 |
| 34 | Prion diseases_Homo sapiens_hsa05020 | 1.13200527 |
| 35 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.12392377 |
| 36 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.10280012 |
| 37 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.07554084 |
| 38 | Lysosome_Homo sapiens_hsa04142 | 1.07369749 |
| 39 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.06593783 |
| 40 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.06470574 |
| 41 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.06095217 |
| 42 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.06038647 |
| 43 | Gap junction_Homo sapiens_hsa04540 | 1.05024887 |
| 44 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.02722178 |
| 45 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.01783004 |
| 46 | Circadian entrainment_Homo sapiens_hsa04713 | 0.97269758 |
| 47 | Pertussis_Homo sapiens_hsa05133 | 0.96818147 |
| 48 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.94576132 |
| 49 | Tight junction_Homo sapiens_hsa04530 | 0.93883595 |
| 50 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.91503495 |
| 51 | Platelet activation_Homo sapiens_hsa04611 | 0.90956712 |
| 52 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.90511649 |
| 53 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.89818006 |
| 54 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89671036 |
| 55 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.89404480 |
| 56 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.89048470 |
| 57 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.88918205 |
| 58 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.88071531 |
| 59 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.87735209 |
| 60 | Phagosome_Homo sapiens_hsa04145 | 0.87654396 |
| 61 | Nicotine addiction_Homo sapiens_hsa05033 | 0.87157170 |
| 62 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.86488870 |
| 63 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.85819472 |
| 64 | Shigellosis_Homo sapiens_hsa05131 | 0.84991240 |
| 65 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.84558532 |
| 66 | Pathways in cancer_Homo sapiens_hsa05200 | 0.84458947 |
| 67 | Salivary secretion_Homo sapiens_hsa04970 | 0.83767331 |
| 68 | Long-term depression_Homo sapiens_hsa04730 | 0.83183216 |
| 69 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.83026161 |
| 70 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.82901284 |
| 71 | Long-term potentiation_Homo sapiens_hsa04720 | 0.82849277 |
| 72 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.81528517 |
| 73 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.79758214 |
| 74 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.79560542 |
| 75 | Colorectal cancer_Homo sapiens_hsa05210 | 0.78389507 |
| 76 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.77040545 |
| 77 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.75998369 |
| 78 | GABAergic synapse_Homo sapiens_hsa04727 | 0.75977152 |
| 79 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.75551664 |
| 80 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.74736327 |
| 81 | Prostate cancer_Homo sapiens_hsa05215 | 0.74536481 |
| 82 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.73501130 |
| 83 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.71338240 |
| 84 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.71122585 |
| 85 | Cocaine addiction_Homo sapiens_hsa05030 | 0.70968156 |
| 86 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.68256794 |
| 87 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.67968034 |
| 88 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.67206063 |
| 89 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.67078784 |
| 90 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.66866635 |
| 91 | Salmonella infection_Homo sapiens_hsa05132 | 0.66149403 |
| 92 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.65762986 |
| 93 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.64135730 |
| 94 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.64000838 |
| 95 | Endocytosis_Homo sapiens_hsa04144 | 0.63903342 |
| 96 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.63885885 |
| 97 | Endometrial cancer_Homo sapiens_hsa05213 | 0.63606879 |
| 98 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.63489108 |
| 99 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.62229134 |
| 100 | Insulin secretion_Homo sapiens_hsa04911 | 0.60333514 |
| 101 | Hepatitis B_Homo sapiens_hsa05161 | 0.58787233 |
| 102 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58018882 |
| 103 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.57519454 |
| 104 | Viral myocarditis_Homo sapiens_hsa05416 | 0.56979052 |
| 105 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.56961454 |
| 106 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.55721012 |
| 107 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.55317136 |
| 108 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.55053260 |
| 109 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.54791604 |
| 110 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.54346783 |
| 111 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.54104512 |
| 112 | Olfactory transduction_Homo sapiens_hsa04740 | 0.53803874 |
| 113 | Morphine addiction_Homo sapiens_hsa05032 | 0.53525939 |
| 114 | Galactose metabolism_Homo sapiens_hsa00052 | 0.52386773 |
| 115 | Renin secretion_Homo sapiens_hsa04924 | 0.51969221 |
| 116 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.51275142 |
| 117 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.50560984 |
| 118 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.50545563 |
| 119 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.50034151 |
| 120 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44875456 |
| 121 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.43059627 |
| 122 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.39568475 |
| 123 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.35397090 |
| 124 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.34538857 |
| 125 | Apoptosis_Homo sapiens_hsa04210 | 0.33398541 |

