CEND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.16029973
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08414751
3synaptic vesicle exocytosis (GO:0016079)5.91091980
4glutamate secretion (GO:0014047)5.57905040
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.44992972
6regulation of synaptic vesicle exocytosis (GO:2000300)5.30156523
7locomotory exploration behavior (GO:0035641)5.21601543
8neuronal action potential propagation (GO:0019227)5.14240053
9vocalization behavior (GO:0071625)5.08793203
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06541220
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.86098148
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85186167
13cerebellar granule cell differentiation (GO:0021707)4.81518863
14neurotransmitter secretion (GO:0007269)4.81039571
15L-amino acid import (GO:0043092)4.71351427
16regulation of synaptic vesicle transport (GO:1902803)4.68631184
17regulation of glutamate receptor signaling pathway (GO:1900449)4.56178010
18protein localization to synapse (GO:0035418)4.51452236
19neuron cell-cell adhesion (GO:0007158)4.38189277
20amino acid import (GO:0043090)4.29779105
21axon ensheathment in central nervous system (GO:0032291)4.28593769
22central nervous system myelination (GO:0022010)4.28593769
23positive regulation of dendritic spine development (GO:0060999)4.23977666
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.20584054
25gamma-aminobutyric acid transport (GO:0015812)4.18225433
26regulation of neuronal synaptic plasticity (GO:0048168)4.16680182
27exploration behavior (GO:0035640)4.16590224
28potassium ion homeostasis (GO:0055075)4.03691822
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.03253935
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02956275
31neuromuscular process controlling posture (GO:0050884)4.02101600
32proline transport (GO:0015824)4.02051256
33regulation of synapse structural plasticity (GO:0051823)4.00456619
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94146663
35neuron-neuron synaptic transmission (GO:0007270)3.93448950
36synaptic transmission, glutamatergic (GO:0035249)3.93269715
37neurotransmitter transport (GO:0006836)3.92520959
38cellular potassium ion homeostasis (GO:0030007)3.92428066
39regulation of synapse maturation (GO:0090128)3.89351839
40potassium ion import (GO:0010107)3.88700006
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85642011
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.82035950
43regulation of ARF protein signal transduction (GO:0032012)3.78147469
44layer formation in cerebral cortex (GO:0021819)3.75684675
45positive regulation of neurotransmitter secretion (GO:0001956)3.74569084
46glutamate receptor signaling pathway (GO:0007215)3.71793019
47neurotransmitter-gated ion channel clustering (GO:0072578)3.66942048
48regulation of neurotransmitter levels (GO:0001505)3.66417639
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65746178
50activation of protein kinase A activity (GO:0034199)3.65314786
51sodium ion export (GO:0071436)3.63122875
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.60095172
53regulation of neurotransmitter secretion (GO:0046928)3.54563392
54long-term memory (GO:0007616)3.53976662
55cellular sodium ion homeostasis (GO:0006883)3.53354470
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52775968
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52710522
58dendritic spine organization (GO:0097061)3.50803484
59regulation of dendritic spine development (GO:0060998)3.49803822
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.47817370
61positive regulation of membrane potential (GO:0045838)3.47291893
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46780611
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45066626
64synaptic vesicle endocytosis (GO:0048488)3.43828697
65membrane depolarization during action potential (GO:0086010)3.42940611
66acidic amino acid transport (GO:0015800)3.42307213
67regulation of synaptic plasticity (GO:0048167)3.39492466
68glycine transport (GO:0015816)3.37440161
69regulation of postsynaptic membrane potential (GO:0060078)3.34497473
70regulation of neurotransmitter transport (GO:0051588)3.34322605
71regulation of vesicle fusion (GO:0031338)3.32064780
72transmission of nerve impulse (GO:0019226)3.30746028
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.30118126
74negative regulation of dendrite morphogenesis (GO:0050774)3.28889188
75long-term synaptic potentiation (GO:0060291)3.28309903
76neuromuscular process controlling balance (GO:0050885)3.26822020
77neurotransmitter uptake (GO:0001504)3.22555237
78positive regulation of neurotransmitter transport (GO:0051590)3.20752526
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.19797175
80dendritic spine morphogenesis (GO:0060997)3.18973967
81cell communication by electrical coupling (GO:0010644)3.18694808
82positive regulation of synapse maturation (GO:0090129)3.17995018
83membrane hyperpolarization (GO:0060081)3.16336245
84neuron recognition (GO:0008038)3.14341814
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14251701
86presynaptic membrane organization (GO:0097090)3.13413570
87chemosensory behavior (GO:0007635)3.12091670
88membrane depolarization (GO:0051899)3.12087967
89vesicle docking involved in exocytosis (GO:0006904)3.11625161
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11481870
91synaptic transmission (GO:0007268)3.10143929
92regulation of voltage-gated calcium channel activity (GO:1901385)3.09839310
93prepulse inhibition (GO:0060134)3.09155939
94negative regulation of microtubule polymerization (GO:0031115)3.08861372
95vesicle transport along microtubule (GO:0047496)3.08020306
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07245126
97response to auditory stimulus (GO:0010996)3.05852757
98cerebellar Purkinje cell layer development (GO:0021680)3.05461737
99dicarboxylic acid transport (GO:0006835)3.04485634
100L-glutamate transport (GO:0015813)3.04293288
101neuromuscular process (GO:0050905)3.03892910
102regulation of exocytosis (GO:0017157)3.03260910
103establishment of mitochondrion localization (GO:0051654)3.01437374
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00071943
105acid secretion (GO:0046717)2.99937700
106regulation of synaptic transmission (GO:0050804)2.99083958
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.98732304
108postsynaptic membrane organization (GO:0001941)2.98560784
109auditory behavior (GO:0031223)2.98479244
110* cerebellar Purkinje cell differentiation (GO:0021702)2.98166182
111positive regulation of synaptic transmission (GO:0050806)2.97883705
112neuronal ion channel clustering (GO:0045161)2.97265818
113innervation (GO:0060384)2.96659801
114behavioral response to cocaine (GO:0048148)2.96423353
115mating behavior (GO:0007617)2.95508196
116neuromuscular synaptic transmission (GO:0007274)2.94867023
117regulation of synaptic transmission, GABAergic (GO:0032228)2.94699958
118establishment of synaptic vesicle localization (GO:0097480)2.91570276
119synaptic vesicle transport (GO:0048489)2.91570276
120learning (GO:0007612)2.90656397
121synapse assembly (GO:0007416)2.90639359
122regulation of dendritic spine morphogenesis (GO:0061001)2.90576720
123calcium ion-dependent exocytosis (GO:0017156)2.90415730
124negative regulation of dendrite development (GO:2000171)2.88502702
125axon cargo transport (GO:0008088)2.85886899
126dendrite morphogenesis (GO:0048813)2.85179425
127regulation of synaptic transmission, dopaminergic (GO:0032225)2.84062443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89081524
2GBX2_23144817_ChIP-Seq_PC3_Human3.59077035
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25005326
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15477121
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09241079
6REST_21632747_ChIP-Seq_MESCs_Mouse2.92192580
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80061365
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80061365
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76148112
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.66526596
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.65900302
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63251736
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63163400
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60330486
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53190042
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52983436
17DROSHA_22980978_ChIP-Seq_HELA_Human2.50018235
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.46753101
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.46133677
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31066212
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.27307153
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.25178216
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19839502
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17169656
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.15264867
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11661043
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07813444
28TAF15_26573619_Chip-Seq_HEK293_Human1.95861518
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87002875
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83997674
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80980145
32AR_21572438_ChIP-Seq_LNCaP_Human1.76921846
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73967846
34SMAD4_21799915_ChIP-Seq_A2780_Human1.66877416
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.66235534
36* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61521626
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57509009
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49001124
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41851830
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41630449
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39625112
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38381800
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37883377
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33694686
45P300_19829295_ChIP-Seq_ESCs_Human1.33368904
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32847349
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31345305
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31294360
49ZNF274_21170338_ChIP-Seq_K562_Hela1.30952328
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30188246
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29645114
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.29602452
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29342461
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.26205306
55AR_25329375_ChIP-Seq_VCAP_Human1.22434206
56LXR_22292898_ChIP-Seq_THP-1_Human1.21181600
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20757806
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.18461381
59STAT3_23295773_ChIP-Seq_U87_Human1.17179482
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16436260
61AR_19668381_ChIP-Seq_PC3_Human1.15922163
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15717966
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14817036
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.14531317
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.11642386
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.10797747
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10251912
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09867562
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09508358
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08851045
71RNF2_27304074_Chip-Seq_NSC_Mouse1.08562731
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07831936
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07671023
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06995619
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05794561
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05319819
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05301698
78* OCT4_19829295_ChIP-Seq_ESCs_Human1.04717644
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.04610995
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04446607
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04431212
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02468233
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01914232
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01000885
85TCF4_23295773_ChIP-Seq_U87_Human1.00824466
86SMC4_20622854_ChIP-Seq_HELA_Human1.00202477
87IGF1R_20145208_ChIP-Seq_DFB_Human0.99404258
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99155217
89* KDM2B_26808549_Chip-Seq_K562_Human0.98692936
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98504684
91RING1B_27294783_Chip-Seq_NPCs_Mouse0.97430614
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.96627188
93AHR_22903824_ChIP-Seq_MCF-7_Human0.96008931
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95851148
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.95555644
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.95335195
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95029668
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94358341
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94277968
100DPY_21335234_ChIP-Seq_ESCs_Mouse0.93273943
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.92119533
102ESR2_21235772_ChIP-Seq_MCF-7_Human0.91223238
103RUNX2_22187159_ChIP-Seq_PCA_Human0.91107986
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90637551
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90584520
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.89644575
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.88890137
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87931325
109KLF4_19829295_ChIP-Seq_ESCs_Human0.87668888
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87526758
111JUN_21703547_ChIP-Seq_K562_Human0.87504146
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87030412
113CTCF_27219007_Chip-Seq_Bcells_Human0.86605754
114* P68_20966046_ChIP-Seq_HELA_Human0.85856619
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84826567
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84735701
117CREB1_26743006_Chip-Seq_LNCaP_Human0.83222213
118VDR_22108803_ChIP-Seq_LS180_Human0.82976930
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82083280
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.81105241
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80769231
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80561883
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80561480
124ER_23166858_ChIP-Seq_MCF-7_Human0.80252933
125SMAD4_21741376_ChIP-Seq_ESCs_Human0.79520000
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79260274
127EGR1_19032775_ChIP-ChIP_M12_Human0.77869446
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76531392
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76152800
130MYC_19915707_ChIP-ChIP_AK7_Human0.75204778
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75174709
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74513232
133KDM2B_26808549_Chip-Seq_DND41_Human0.74352917
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72678683
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71471635
136NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.70413604
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.70383757
138* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.69579358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03674536
2MP0003880_abnormal_central_pattern4.68213743
3MP0003635_abnormal_synaptic_transmissio4.00944608
4MP0004270_analgesia3.80386477
5MP0001968_abnormal_touch/_nociception3.49544961
6MP0009046_muscle_twitch3.44948182
7MP0009745_abnormal_behavioral_response3.34463524
8MP0002064_seizures3.25083146
9MP0002063_abnormal_learning/memory/cond3.11794947
10MP0002734_abnormal_mechanical_nocicepti2.96060002
11MP0002735_abnormal_chemical_nociception2.89261205
12MP0002822_catalepsy2.87161875
13MP0002736_abnormal_nociception_after2.86096572
14MP0002272_abnormal_nervous_system2.84583341
15MP0002572_abnormal_emotion/affect_behav2.73151345
16MP0005423_abnormal_somatic_nervous2.64603406
17MP0001486_abnormal_startle_reflex2.50501661
18MP0002733_abnormal_thermal_nociception2.41263499
19MP0001970_abnormal_pain_threshold2.30557388
20MP0001501_abnormal_sleep_pattern2.30455374
21MP0006276_abnormal_autonomic_nervous2.27329809
22MP0002067_abnormal_sensory_capabilities2.11367152
23MP0001440_abnormal_grooming_behavior2.07373014
24MP0004858_abnormal_nervous_system2.00051248
25MP0008569_lethality_at_weaning1.95452341
26MP0002184_abnormal_innervation1.93021475
27MP0001984_abnormal_olfaction1.91150505
28MP0003329_amyloid_beta_deposits1.77916962
29* MP0004811_abnormal_neuron_physiology1.76972799
30MP0005386_behavior/neurological_phenoty1.76658410
31MP0004924_abnormal_behavior1.76658410
32MP0005646_abnormal_pituitary_gland1.72831512
33MP0002557_abnormal_social/conspecific_i1.71031055
34MP0002909_abnormal_adrenal_gland1.67666557
35MP0003123_paternal_imprinting1.64461094
36MP0009780_abnormal_chondrocyte_physiolo1.62731752
37MP0000955_abnormal_spinal_cord1.60961629
38MP0004142_abnormal_muscle_tone1.60630682
39MP0000778_abnormal_nervous_system1.58861796
40MP0003879_abnormal_hair_cell1.50945900
41MP0001529_abnormal_vocalization1.50226814
42MP0003122_maternal_imprinting1.47268462
43MP0001905_abnormal_dopamine_level1.45336373
44MP0003787_abnormal_imprinting1.44889392
45* MP0002882_abnormal_neuron_morphology1.43917539
46* MP0002066_abnormal_motor_capabilities/c1.43012907
47MP0003633_abnormal_nervous_system1.34220994
48MP0005645_abnormal_hypothalamus_physiol1.25550435
49MP0004885_abnormal_endolymph1.25518207
50MP0001502_abnormal_circadian_rhythm1.19578788
51MP0003631_nervous_system_phenotype1.14557203
52MP0000751_myopathy1.13334817
53MP0002229_neurodegeneration1.12572695
54MP0008872_abnormal_physiological_respon1.08796922
55MP0001188_hyperpigmentation1.02054167
56* MP0002152_abnormal_brain_morphology0.98672420
57MP0008874_decreased_physiological_sensi0.95976178
58MP0005551_abnormal_eye_electrophysiolog0.93874610
59MP0004145_abnormal_muscle_electrophysio0.93526514
60MP0005167_abnormal_blood-brain_barrier0.92410735
61MP0001986_abnormal_taste_sensitivity0.91719306
62MP0003634_abnormal_glial_cell0.91587300
63MP0000920_abnormal_myelination0.88177351
64MP0005499_abnormal_olfactory_system0.87333390
65MP0005394_taste/olfaction_phenotype0.87333390
66MP0002069_abnormal_eating/drinking_beha0.87052398
67MP0004742_abnormal_vestibular_system0.87028715
68MP0010386_abnormal_urinary_bladder0.85739710
69MP0000013_abnormal_adipose_tissue0.85696225
70MP0005535_abnormal_body_temperature0.84351981
71MP0002752_abnormal_somatic_nervous0.83770534
72MP0001346_abnormal_lacrimal_gland0.83246309
73MP0001963_abnormal_hearing_physiology0.83037839
74MP0004085_abnormal_heartbeat0.80853149
75MP0003632_abnormal_nervous_system0.80716607
76MP0008877_abnormal_DNA_methylation0.79520025
77MP0001348_abnormal_lacrimal_gland0.79400486
78MP0003690_abnormal_glial_cell0.78807682
79MP0000604_amyloidosis0.78737947
80MP0002837_dystrophic_cardiac_calcinosis0.78565587
81MP0004147_increased_porphyrin_level0.77979918
82MP0001177_atelectasis0.74962575
83MP0002638_abnormal_pupillary_reflex0.71688997
84MP0003121_genomic_imprinting0.70087808
85MP0004215_abnormal_myocardial_fiber0.69124683
86MP0002090_abnormal_vision0.66493997
87MP0001485_abnormal_pinna_reflex0.66036158
88MP0001664_abnormal_digestion0.65031289
89MP0003075_altered_response_to0.63870541
90MP0000569_abnormal_digit_pigmentation0.63394267
91MP0004233_abnormal_muscle_weight0.61930404
92MP0002876_abnormal_thyroid_physiology0.60905119
93MP0004484_altered_response_of0.60648819
94MP0001299_abnormal_eye_distance/0.60147478
95MP0003183_abnormal_peptide_metabolism0.60131214
96MP0004130_abnormal_muscle_cell0.60019028
97MP0008961_abnormal_basal_metabolism0.59724690
98MP0005623_abnormal_meninges_morphology0.59642750
99MP0003137_abnormal_impulse_conducting0.59541646
100MP0000631_abnormal_neuroendocrine_gland0.57113764
101MP0001943_abnormal_respiration0.55991997
102MP0003646_muscle_fatigue0.55469305
103MP0002653_abnormal_ependyma_morphology0.53745925
104MP0000026_abnormal_inner_ear0.53168906
105MP0002751_abnormal_autonomic_nervous0.53076194
106* MP0003861_abnormal_nervous_system0.51823986
107MP0003283_abnormal_digestive_organ0.51711785
108MP0010769_abnormal_survival0.51706194
109MP0010768_mortality/aging0.51422261
110MP0002082_postnatal_lethality0.50156212
111MP0010770_preweaning_lethality0.50156212
112MP0003956_abnormal_body_size0.50121944
113MP0000639_abnormal_adrenal_gland0.48409522
114MP0000579_abnormal_nail_morphology0.47387035
115MP0003172_abnormal_lysosome_physiology0.46423120
116MP0002873_normal_phenotype0.45726143

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.80248863
2Focal motor seizures (HP:0011153)7.42394502
3Focal seizures (HP:0007359)5.63940780
4Atonic seizures (HP:0010819)5.22748669
5Visual hallucinations (HP:0002367)5.12133243
6Febrile seizures (HP:0002373)4.88983829
7Epileptic encephalopathy (HP:0200134)4.70283170
8Progressive cerebellar ataxia (HP:0002073)4.65879790
9Action tremor (HP:0002345)4.51442841
10Absence seizures (HP:0002121)4.34658066
11Dialeptic seizures (HP:0011146)3.90475680
12Generalized tonic-clonic seizures (HP:0002069)3.89094517
13Cerebral hypomyelination (HP:0006808)3.84249870
14Supranuclear gaze palsy (HP:0000605)3.75522272
15Ankle clonus (HP:0011448)3.60691265
16Pheochromocytoma (HP:0002666)3.54605668
17Tetraplegia (HP:0002445)3.33896473
18Gaze-evoked nystagmus (HP:0000640)3.25696793
19Impaired vibration sensation in the lower limbs (HP:0002166)3.23095967
20Depression (HP:0000716)3.22160787
21Obstructive sleep apnea (HP:0002870)3.17485799
22Neuroendocrine neoplasm (HP:0100634)3.16869057
23Anxiety (HP:0000739)3.13952525
24Abnormal eating behavior (HP:0100738)3.12243827
25Truncal ataxia (HP:0002078)3.07169694
26Dysdiadochokinesis (HP:0002075)3.05070686
27Dysmetria (HP:0001310)3.03746331
28Limb dystonia (HP:0002451)3.03415862
29Urinary bladder sphincter dysfunction (HP:0002839)3.02512075
30Broad-based gait (HP:0002136)2.99620044
31Poor eye contact (HP:0000817)2.96877199
32Akinesia (HP:0002304)2.92900214
33Postural instability (HP:0002172)2.87249639
34Insidious onset (HP:0003587)2.86808480
35Termporal pattern (HP:0011008)2.86808480
36Abnormal social behavior (HP:0012433)2.79461785
37Impaired social interactions (HP:0000735)2.79461785
38Amblyopia (HP:0000646)2.78138915
39Torticollis (HP:0000473)2.77579686
40Mutism (HP:0002300)2.76941550
41Scanning speech (HP:0002168)2.73967889
42Urinary urgency (HP:0000012)2.73625431
43Progressive inability to walk (HP:0002505)2.72770551
44Insomnia (HP:0100785)2.69116412
45Peripheral hypomyelination (HP:0007182)2.68412786
46Spastic gait (HP:0002064)2.67164909
47Hyperventilation (HP:0002883)2.66104137
48Apathy (HP:0000741)2.62612850
49Focal dystonia (HP:0004373)2.61893698
50Ventricular fibrillation (HP:0001663)2.59262556
51Sleep apnea (HP:0010535)2.58906450
52Abnormality of the lower motor neuron (HP:0002366)2.51943613
53Bradykinesia (HP:0002067)2.46967024
54Genetic anticipation (HP:0003743)2.45124650
55Failure to thrive in infancy (HP:0001531)2.43882522
56Craniofacial dystonia (HP:0012179)2.40891120
57Diminished motivation (HP:0000745)2.39441492
58Impaired smooth pursuit (HP:0007772)2.38900424
59Hemiplegia (HP:0002301)2.37724060
60CNS hypomyelination (HP:0003429)2.37602295
61Spastic tetraparesis (HP:0001285)2.36352159
62Abnormality of the corticospinal tract (HP:0002492)2.34429335
63Papilledema (HP:0001085)2.34408734
64Diplopia (HP:0000651)2.33351017
65Abnormality of binocular vision (HP:0011514)2.33351017
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.32310406
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32310406
68Intention tremor (HP:0002080)2.29861096
69Neoplasm of the peripheral nervous system (HP:0100007)2.29294429
70Choreoathetosis (HP:0001266)2.27660632
71Polyphagia (HP:0002591)2.27469210
72Status epilepticus (HP:0002133)2.26678572
73Epileptiform EEG discharges (HP:0011182)2.25354473
74Morphological abnormality of the pyramidal tract (HP:0002062)2.24907818
75Hemiparesis (HP:0001269)2.24301289
76Fetal akinesia sequence (HP:0001989)2.23419245
77Lower limb muscle weakness (HP:0007340)2.18996858
78Dysmetric saccades (HP:0000641)2.18714823
79Impaired vibratory sensation (HP:0002495)2.17405434
80EEG with generalized epileptiform discharges (HP:0011198)2.16766606
81Megalencephaly (HP:0001355)2.16656400
82Annular pancreas (HP:0001734)2.12266546
83Abnormality of ocular smooth pursuit (HP:0000617)2.11913752
84Drooling (HP:0002307)2.08855333
85Excessive salivation (HP:0003781)2.08855333
86Ulnar claw (HP:0001178)2.08849981
87Hypsarrhythmia (HP:0002521)2.08021876
88Impaired pain sensation (HP:0007328)2.07237200
89Abnormality of pain sensation (HP:0010832)2.07237200
90Inability to walk (HP:0002540)2.06499414
91Agitation (HP:0000713)2.06069726
92Spinal canal stenosis (HP:0003416)2.05976063
93Postural tremor (HP:0002174)2.04631039
94Lower limb asymmetry (HP:0100559)2.02004060
95Hypoventilation (HP:0002791)2.00838326
96Incomplete penetrance (HP:0003829)1.99286547
97Neurofibrillary tangles (HP:0002185)1.98480834
98Stereotypic behavior (HP:0000733)1.98379835
99Gait ataxia (HP:0002066)1.98221221
100Resting tremor (HP:0002322)1.96558004
101Cerebral inclusion bodies (HP:0100314)1.95392067
102Specific learning disability (HP:0001328)1.94543738
103Psychosis (HP:0000709)1.94043902
104Delusions (HP:0000746)1.93956473
105Myotonia (HP:0002486)1.93776585
106Generalized myoclonic seizures (HP:0002123)1.93620367
107Bundle branch block (HP:0011710)1.91073126
108Lower limb amyotrophy (HP:0007210)1.90445436
109Rigidity (HP:0002063)1.90074792
110Absent speech (HP:0001344)1.89076238
111Neuronal loss in central nervous system (HP:0002529)1.88988061
112Abnormality of saccadic eye movements (HP:0000570)1.88616767
113Hand muscle atrophy (HP:0009130)1.88186152
114Clonus (HP:0002169)1.87480351
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87118543
116Amyotrophic lateral sclerosis (HP:0007354)1.84690486
117Hypercortisolism (HP:0001578)1.84460721
118Pointed chin (HP:0000307)1.84012848
119Gait imbalance (HP:0002141)1.83456297
120Poor suck (HP:0002033)1.82906128
121Aplasia involving bones of the extremities (HP:0009825)1.82360904
122Aplasia involving bones of the upper limbs (HP:0009823)1.82360904
123Aplasia of the phalanges of the hand (HP:0009802)1.82360904
124Split foot (HP:0001839)1.81741587
125Abnormal hair whorl (HP:0010721)1.80195674
126Increased circulating renin level (HP:0000848)1.79905105
127Rapidly progressive (HP:0003678)1.77706454
128Upper limb amyotrophy (HP:0009129)1.77551919
129Distal upper limb amyotrophy (HP:0007149)1.77551919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.46812229
2MAP3K93.77138261
3EPHA43.19338256
4MAP3K43.18211261
5MINK13.00051580
6MAP3K122.90220390
7MAP2K72.71685123
8MARK12.53538596
9DAPK22.29702101
10PAK62.23730510
11KSR22.14543601
12MAP2K42.12050042
13CASK2.08165919
14GRK52.07200947
15NTRK11.99554338
16NTRK21.80310847
17ARAF1.73951101
18CDK191.73327601
19CAMKK11.71757846
20PRKD31.60987226
21PLK21.55639439
22RIPK41.54564688
23DAPK11.51507782
24CDK51.50895065
25RIPK11.39818108
26STK381.37189818
27PRKCG1.31589939
28LMTK21.31315350
29MAPK131.29538409
30PHKG21.27418936
31PHKG11.27418936
32KSR11.24162609
33MAP3K21.23588219
34CAMKK21.22665059
35UHMK11.21779145
36PNCK1.18815488
37PRPF4B1.14563604
38SGK2231.11731097
39SGK4941.11731097
40FES1.09667115
41LATS21.09152279
42TNIK1.05012443
43NEK11.04442507
44MAP3K111.03152587
45OXSR11.02475761
46CDK141.00890649
47CDK181.00357268
48CAMK2A0.99853106
49PINK10.97906639
50CDK150.97275813
51RET0.93401194
52WNK10.88037883
53BRSK10.87566084
54TYRO30.85286192
55MAPK120.85057146
56SGK20.84886720
57CDK11A0.84853276
58CAMK2B0.82896933
59SIK20.81731750
60PRKCH0.81568396
61LIMK10.81413493
62CAMK10.81082458
63PKN10.80036398
64MAP3K130.78961829
65TAOK10.78628820
66STK110.75373623
67TNK20.74853188
68PAK30.73492935
69SGK30.71360905
70CSNK1G20.70871502
71PTK2B0.67300625
72CAMK2G0.66888388
73CAMK40.66595422
74MAP3K10.65224082
75PDK10.64768580
76NME10.64619308
77TESK10.62194376
78PDPK10.61246081
79MAPKAPK50.59917563
80CAMK2D0.59446731
81ALK0.59093088
82RAF10.56846598
83STK390.56216458
84DYRK1A0.55982766
85PRKCE0.54047972
86SGK10.52618468
87FER0.51237928
88CCNB10.50994343
89SIK30.49666581
90MAP2K10.48639684
91AKT30.47539519
92MARK20.47501443
93PDK30.46752984
94PDK40.46752984
95BRAF0.46639396
96PRKCZ0.46243962
97DAPK30.46159396
98BMPR20.44338940
99CDC42BPA0.44008158
100RPS6KA30.43626252
101ROCK20.42629287
102RPS6KA20.41284504
103MAPK100.39128162
104FYN0.38182104
105NEK60.37577531
106ADRBK10.37296714
107PRKG20.36879525
108SCYL20.36831543
109FGFR20.35648669
110PRKCA0.34937119
111TAOK20.32551807
112ICK0.28940527
113ERBB20.27597703
114MAPK80.27393912
115IRAK20.26938422
116ROCK10.26326161
117PRKACA0.24950210
118SRC0.23644958
119MAP2K60.23086676

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.99180335
2Nicotine addiction_Homo sapiens_hsa050333.55721617
3Olfactory transduction_Homo sapiens_hsa047402.95820626
4GABAergic synapse_Homo sapiens_hsa047272.71649985
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55951856
6Circadian entrainment_Homo sapiens_hsa047132.54759949
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43124679
8Long-term potentiation_Homo sapiens_hsa047202.42580224
9Morphine addiction_Homo sapiens_hsa050322.39211210
10Glutamatergic synapse_Homo sapiens_hsa047242.38769714
11Amphetamine addiction_Homo sapiens_hsa050312.28439863
12Dopaminergic synapse_Homo sapiens_hsa047282.17317077
13Collecting duct acid secretion_Homo sapiens_hsa049662.10852056
14Salivary secretion_Homo sapiens_hsa049702.07894226
15Insulin secretion_Homo sapiens_hsa049111.98635131
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94930157
17Cholinergic synapse_Homo sapiens_hsa047251.85568468
18Taste transduction_Homo sapiens_hsa047421.84742731
19Gastric acid secretion_Homo sapiens_hsa049711.80108123
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64967140
21Serotonergic synapse_Homo sapiens_hsa047261.64459635
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62505829
23Vitamin B6 metabolism_Homo sapiens_hsa007501.60719254
24Long-term depression_Homo sapiens_hsa047301.59048237
25Cocaine addiction_Homo sapiens_hsa050301.57629411
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49453862
27Renin secretion_Homo sapiens_hsa049241.48839602
28Oxytocin signaling pathway_Homo sapiens_hsa049211.45821355
29Calcium signaling pathway_Homo sapiens_hsa040201.44639384
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35885075
31Vibrio cholerae infection_Homo sapiens_hsa051101.34590097
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33827562
33GnRH signaling pathway_Homo sapiens_hsa049121.32861110
34Cardiac muscle contraction_Homo sapiens_hsa042601.29548006
35Gap junction_Homo sapiens_hsa045401.29136119
36cAMP signaling pathway_Homo sapiens_hsa040241.13093329
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09272624
38Oxidative phosphorylation_Homo sapiens_hsa001901.06260469
39Estrogen signaling pathway_Homo sapiens_hsa049151.02178897
40Type II diabetes mellitus_Homo sapiens_hsa049301.00983078
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98755250
42Glioma_Homo sapiens_hsa052140.98140993
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96806523
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94624486
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92712083
46Parkinsons disease_Homo sapiens_hsa050120.92106441
47Phototransduction_Homo sapiens_hsa047440.91735999
48ErbB signaling pathway_Homo sapiens_hsa040120.90560985
49Melanogenesis_Homo sapiens_hsa049160.89786008
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89098663
51Nitrogen metabolism_Homo sapiens_hsa009100.88969433
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87528051
53Axon guidance_Homo sapiens_hsa043600.87270468
54Alzheimers disease_Homo sapiens_hsa050100.87146709
55Oocyte meiosis_Homo sapiens_hsa041140.82895012
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82079322
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.81703709
58Dorso-ventral axis formation_Homo sapiens_hsa043200.76106737
59Pancreatic secretion_Homo sapiens_hsa049720.75165900
60Thyroid hormone synthesis_Homo sapiens_hsa049180.74074337
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.70647381
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66792828
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66620971
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65499388
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63996608
66MAPK signaling pathway_Homo sapiens_hsa040100.61139801
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.60681693
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60447685
69Dilated cardiomyopathy_Homo sapiens_hsa054140.58867542
70Choline metabolism in cancer_Homo sapiens_hsa052310.56371082
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55653386
72Arginine and proline metabolism_Homo sapiens_hsa003300.54578000
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54081013
74Endocytosis_Homo sapiens_hsa041440.52573893
75Glucagon signaling pathway_Homo sapiens_hsa049220.52016511
76Huntingtons disease_Homo sapiens_hsa050160.51650238
77Type I diabetes mellitus_Homo sapiens_hsa049400.51167152
78Ras signaling pathway_Homo sapiens_hsa040140.50903610
79Alcoholism_Homo sapiens_hsa050340.50883000
80Bile secretion_Homo sapiens_hsa049760.50648947
81VEGF signaling pathway_Homo sapiens_hsa043700.46419687
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.45945759
83Inositol phosphate metabolism_Homo sapiens_hsa005620.45416338
84Rap1 signaling pathway_Homo sapiens_hsa040150.44320414
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41424090
86Insulin signaling pathway_Homo sapiens_hsa049100.41323699
87Arginine biosynthesis_Homo sapiens_hsa002200.38260140
88Rheumatoid arthritis_Homo sapiens_hsa053230.37923192
89Prion diseases_Homo sapiens_hsa050200.36411833
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36170129
91mTOR signaling pathway_Homo sapiens_hsa041500.35733186
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32950648
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32772814
94Endometrial cancer_Homo sapiens_hsa052130.32460036
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30969353
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30785982
97Histidine metabolism_Homo sapiens_hsa003400.30650433
98Wnt signaling pathway_Homo sapiens_hsa043100.30462692
99Circadian rhythm_Homo sapiens_hsa047100.30062546
100Phagosome_Homo sapiens_hsa041450.29377679
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28118843
102Renal cell carcinoma_Homo sapiens_hsa052110.28035751
103Non-small cell lung cancer_Homo sapiens_hsa052230.27853344
104Ovarian steroidogenesis_Homo sapiens_hsa049130.26590664
105Fatty acid biosynthesis_Homo sapiens_hsa000610.26102066
106Mineral absorption_Homo sapiens_hsa049780.25129708
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.24089559
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23864923
109AMPK signaling pathway_Homo sapiens_hsa041520.23129519
110beta-Alanine metabolism_Homo sapiens_hsa004100.23020710
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22963532
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22183976
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20145725
114Hippo signaling pathway_Homo sapiens_hsa043900.17136104
115HIF-1 signaling pathway_Homo sapiens_hsa040660.16154396

Most similar genes based on co-expression Upload to Enrichr

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