CENPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.17023560
2COPI coating of Golgi vesicle (GO:0048205)4.17023560
3plasma membrane repair (GO:0001778)3.99705778
4regulation of early endosome to late endosome transport (GO:2000641)3.89281775
5protein retention in ER lumen (GO:0006621)3.78053537
6barbed-end actin filament capping (GO:0051016)3.71574483
7regulation of mammary gland epithelial cell proliferation (GO:0033599)3.71130378
8regulation of fatty acid beta-oxidation (GO:0031998)3.59865870
9positive regulation of fatty acid beta-oxidation (GO:0032000)3.59108687
10apoptotic cell clearance (GO:0043277)3.52996591
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.51581581
12apoptotic process involved in morphogenesis (GO:0060561)3.41028462
13negative regulation of erythrocyte differentiation (GO:0045647)3.36861664
14activation of Rac GTPase activity (GO:0032863)3.34078153
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.31953717
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31713704
17negative regulation of cell size (GO:0045792)3.30489206
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27084550
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26822475
20negative regulation of fatty acid transport (GO:2000192)3.23019640
21regulation of extracellular matrix disassembly (GO:0010715)3.22571783
22regulation of fatty acid oxidation (GO:0046320)3.22499496
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20508680
24stress fiber assembly (GO:0043149)3.20495728
25positive regulation of fatty acid oxidation (GO:0046321)3.20246333
26lysine metabolic process (GO:0006553)3.19561364
27lysine catabolic process (GO:0006554)3.19561364
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.16224792
29low-density lipoprotein particle clearance (GO:0034383)3.15314374
30positive regulation of blood vessel endothelial cell migration (GO:0043536)3.14503712
31fatty acid transmembrane transport (GO:1902001)3.11675526
32regulation of p38MAPK cascade (GO:1900744)3.07417140
33protein localization to endosome (GO:0036010)3.06948236
34carnitine shuttle (GO:0006853)3.05555097
35vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.05382102
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.04206254
37protein heterotrimerization (GO:0070208)3.03200415
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.01239404
39positive regulation of histone deacetylation (GO:0031065)2.96095136
40negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95756081
41endothelial cell chemotaxis (GO:0035767)2.93983785
42proline biosynthetic process (GO:0006561)2.90912337
43positive regulation of receptor recycling (GO:0001921)2.90369512
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90001661
45regulation of cholesterol storage (GO:0010885)2.89940978
46mannose metabolic process (GO:0006013)2.88989019
47desmosome organization (GO:0002934)2.88746179
48growth hormone receptor signaling pathway (GO:0060396)2.88606448
49tricarboxylic acid metabolic process (GO:0072350)2.88458820
502-oxoglutarate metabolic process (GO:0006103)2.85261071
51negative regulation of potassium ion transmembrane transport (GO:1901380)2.81930658
52regulation of cholesterol homeostasis (GO:2000188)2.79941827
53positive regulation of glycogen biosynthetic process (GO:0045725)2.78916089
54cell-substrate junction assembly (GO:0007044)2.75550177
55pinocytosis (GO:0006907)2.74737546
56cardiac myofibril assembly (GO:0055003)2.70995235
57sarcomere organization (GO:0045214)2.69547487
58adherens junction assembly (GO:0034333)2.68475719
59glucose 6-phosphate metabolic process (GO:0051156)2.68202589
60branching involved in mammary gland duct morphogenesis (GO:0060444)2.68057728
61pentose-phosphate shunt (GO:0006098)2.67412944
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.65054629
63positive regulation of p38MAPK cascade (GO:1900745)2.64653255
64modulation by symbiont of host cellular process (GO:0044068)2.63869572
65regulation of sequestering of triglyceride (GO:0010889)2.62856023
66maternal placenta development (GO:0001893)2.62249279
67negative regulation of cardiac muscle tissue growth (GO:0055022)2.60994614
68negative regulation of heart growth (GO:0061117)2.60994614
69cell-cell junction maintenance (GO:0045217)2.60104415
70positive regulation of protein dephosphorylation (GO:0035307)2.59087886
71endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57298169
72protein targeting to plasma membrane (GO:0072661)2.55777739
73response to laminar fluid shear stress (GO:0034616)2.55676176
74embryonic process involved in female pregnancy (GO:0060136)2.54487631
75alpha-linolenic acid metabolic process (GO:0036109)2.53813425
76embryo implantation (GO:0007566)2.53712646
77fatty acid beta-oxidation (GO:0006635)2.53170148
78modulation by virus of host morphology or physiology (GO:0019048)2.51286080
79hemidesmosome assembly (GO:0031581)2.49661586
80glucose catabolic process (GO:0006007)2.49151617
81regulation of apoptotic process involved in morphogenesis (GO:1902337)2.48423727
82focal adhesion assembly (GO:0048041)2.46892642
83cell-substrate adherens junction assembly (GO:0007045)2.46892642
84activation of MAPKKK activity (GO:0000185)2.46042000
85valine metabolic process (GO:0006573)2.45859880
86negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.45515871
87regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.45514140
88embryonic eye morphogenesis (GO:0048048)2.45209276
89positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.44489090
90positive regulation of extracellular matrix organization (GO:1903055)2.44353164
914-hydroxyproline metabolic process (GO:0019471)2.44351357
92carnitine transport (GO:0015879)2.44200056
93amino-acid betaine transport (GO:0015838)2.44200056
94protein maturation by protein folding (GO:0022417)2.43850531
95sulfur amino acid catabolic process (GO:0000098)2.43362823
96negative regulation of skeletal muscle tissue development (GO:0048642)2.42688150
97cell adhesion mediated by integrin (GO:0033627)2.42632566
98cellular response to growth hormone stimulus (GO:0071378)2.42574842
99basement membrane organization (GO:0071711)2.42486880
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42378348
101vascular endothelial growth factor signaling pathway (GO:0038084)2.42019767
102actin filament bundle organization (GO:0061572)2.41945961
103actin filament bundle assembly (GO:0051017)2.41945961
104epithelial cell-cell adhesion (GO:0090136)2.40911811
105positive regulation of lipid catabolic process (GO:0050996)2.39779182
106negative regulation of viral release from host cell (GO:1902187)2.38689742
107atrioventricular valve morphogenesis (GO:0003181)2.38529677
108embryonic foregut morphogenesis (GO:0048617)2.38099084
109regulation of extracellular matrix organization (GO:1903053)2.37984579
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37876235
111regulation of NFAT protein import into nucleus (GO:0051532)2.37774854
112carnitine transmembrane transport (GO:1902603)2.37678965
113peptidyl-proline hydroxylation (GO:0019511)2.37336709
114UV protection (GO:0009650)2.36780087
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.36468566
116cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36126141
117skin morphogenesis (GO:0043589)2.35285174
118regulation of hippo signaling (GO:0035330)2.34876714
119positive regulation of glycogen metabolic process (GO:0070875)2.34545995
120intracellular estrogen receptor signaling pathway (GO:0030520)2.33109864
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31457972
122negative regulation of focal adhesion assembly (GO:0051895)2.30447272
123negative regulation of cell junction assembly (GO:1901889)2.30447272
124negative regulation of adherens junction organization (GO:1903392)2.30447272
125positive regulation of cellular response to insulin stimulus (GO:1900078)2.29105746
126fatty acid oxidation (GO:0019395)2.29034244
127adhesion of symbiont to host (GO:0044406)2.28899589
128aspartate family amino acid catabolic process (GO:0009068)2.28516170
129endocytic recycling (GO:0032456)2.28227992
130positive regulation of keratinocyte differentiation (GO:0045618)2.27850317
131regulation of cholesterol biosynthetic process (GO:0045540)2.27197733
132regulation of membrane protein ectodomain proteolysis (GO:0051043)2.26941090
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.25850037
134myofibril assembly (GO:0030239)2.25306187
135sodium ion export (GO:0071436)2.24553238
136modulation by virus of host process (GO:0019054)2.24363951
137negative regulation of lipid transport (GO:0032369)2.24343189
138lipid oxidation (GO:0034440)2.23772147
139fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.23663300
140positive regulation of fatty acid metabolic process (GO:0045923)2.23402378
141semaphorin-plexin signaling pathway (GO:0071526)2.23066250
142positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.22363413
143positive regulation of triglyceride biosynthetic process (GO:0010867)2.21779687
144cell communication involved in cardiac conduction (GO:0086065)2.21638105
145blood vessel endothelial cell migration (GO:0043534)2.20757979
146cell migration involved in sprouting angiogenesis (GO:0002042)2.20706345
147apoptotic process involved in development (GO:1902742)2.20557890
148eye morphogenesis (GO:0048592)2.18944458
149regulation of tight junction assembly (GO:2000810)2.18787255
150cellular response to nutrient (GO:0031670)2.18656976
151activation of JUN kinase activity (GO:0007257)2.18393270
152cell volume homeostasis (GO:0006884)2.17563879
153tricarboxylic acid cycle (GO:0006099)2.17145131
154endoplasmic reticulum unfolded protein response (GO:0030968)2.17092270
155cell communication by electrical coupling (GO:0010644)2.17042394
156glial cell proliferation (GO:0014009)2.16952261
157actin-myosin filament sliding (GO:0033275)2.16659779
158muscle filament sliding (GO:0030049)2.16659779
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.16595833
160protein localization to microtubule (GO:0035372)2.16452989
161regulation of glucose import in response to insulin stimulus (GO:2001273)2.16054091
162cardiac muscle contraction (GO:0060048)2.15849739
163oxaloacetate metabolic process (GO:0006107)2.15347756
164cortical actin cytoskeleton organization (GO:0030866)2.14023885
165regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13872227
166actomyosin structure organization (GO:0031032)2.12491673
167cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.12309407
168renal absorption (GO:0070293)2.11632908
169positive regulation of nuclease activity (GO:0032075)2.11598442
170epoxygenase P450 pathway (GO:0019373)2.11414093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27953690
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.09237241
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.03396569
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.96589758
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76676575
6CLOCK_20551151_ChIP-Seq_293T_Human2.53326086
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.45368850
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.45292410
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31551270
10ZNF263_19887448_ChIP-Seq_K562_Human2.29184795
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28241864
12LXR_22292898_ChIP-Seq_THP-1_Human2.20573732
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.09794930
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04165533
15* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03520920
16KDM2B_26808549_Chip-Seq_DND41_Human1.96078709
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.95784985
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.94054010
19RACK7_27058665_Chip-Seq_MCF-7_Human1.92699758
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85037315
21KDM2B_26808549_Chip-Seq_K562_Human1.84987720
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83113174
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74390923
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73142548
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72853992
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69326205
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69008368
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68974582
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66152270
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64781042
31TCF7_22412390_ChIP-Seq_EML_Mouse1.59933025
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.57688788
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57508144
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.56992438
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.56992438
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56663371
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56045952
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54260711
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.48829640
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47733153
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.47560935
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47072521
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46242225
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43904421
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42307284
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42023456
47VDR_21846776_ChIP-Seq_THP-1_Human1.40215542
48* ATF3_27146783_Chip-Seq_COLON_Human1.39431245
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38906947
50VDR_24763502_ChIP-Seq_THP-1_Human1.37575218
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.37331537
52CREB1_26743006_Chip-Seq_LNCaP_Human1.37093890
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37030906
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36215176
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35583627
56MYC_22102868_ChIP-Seq_BL_Human1.35155344
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32197760
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31480709
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30308272
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.28421047
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23574141
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23339108
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.23214310
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23160845
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22904074
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20585838
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20293103
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19630486
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19513866
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.19459408
71GATA1_19941826_ChIP-Seq_K562_Human1.19226746
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19122452
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18387520
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17798991
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17086171
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15923457
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15808269
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.15291880
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.14914335
80* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14533399
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14465113
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.14201771
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13194793
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12818553
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12507538
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10848903
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10436216
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09430000
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09173334
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07534062
91FOXA2_19822575_ChIP-Seq_HepG2_Human1.07120143
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07022134
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06511492
94TP53_22127205_ChIP-Seq_IMR90_Human1.05654665
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05242503
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04188241
97P68_20966046_ChIP-Seq_HELA_Human1.03361965
98DROSHA_22980978_ChIP-Seq_HELA_Human1.02633934
99* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02623551
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02084599
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01784813
102SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01584252
103CTCF_27219007_Chip-Seq_Bcells_Human1.01551154
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.01367686
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00403794
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99015369
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98760656
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.98634360
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98536990
110MAF_26560356_Chip-Seq_TH2_Human0.98012954
111NCOR1_26117541_ChIP-Seq_K562_Human0.97808113
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.97171631
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97093275
114SMC4_20622854_ChIP-Seq_HELA_Human0.96766937
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.96583762
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96420613
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95510353
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95126649
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95095432
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93757705
121SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93694831
122SA1_27219007_Chip-Seq_ERYTHROID_Human0.93518657
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92631457
124* TP63_22573176_ChIP-Seq_HFKS_Human0.91997178
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91858461
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91849872
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91227477
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91139120
129MAF_26560356_Chip-Seq_TH1_Human0.90818315
130UBF1/2_26484160_Chip-Seq_HMECs_Human0.90698133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.71364262
2MP0008438_abnormal_cutaneous_collagen3.63924008
3MP0005451_abnormal_body_composition2.75792206
4MP0002837_dystrophic_cardiac_calcinosis2.70369565
5MP0004130_abnormal_muscle_cell2.60227103
6MP0000751_myopathy2.54464309
7MP0005275_abnormal_skin_tensile2.46138793
8MP0003300_gastrointestinal_ulcer2.30815541
9MP0005409_darkened_coat_color2.23658450
10MP0004185_abnormal_adipocyte_glucose2.18749410
11MP0001958_emphysema2.16171181
12MP0005360_urolithiasis2.03655341
13MP0005666_abnormal_adipose_tissue2.03032582
14MP0003453_abnormal_keratinocyte_physiol2.01464600
15MP0010234_abnormal_vibrissa_follicle1.99729808
16MP0002139_abnormal_hepatobiliary_system1.94457382
17MP0003303_peritoneal_inflammation1.93438379
18MP0003566_abnormal_cell_adhesion1.92614297
19MP0003279_aneurysm1.90631982
20MP0004087_abnormal_muscle_fiber1.79387983
21MP0003191_abnormal_cellular_cholesterol1.79361265
22MP0004084_abnormal_cardiac_muscle1.79077200
23MP0005375_adipose_tissue_phenotype1.75221877
24MP0002877_abnormal_melanocyte_morpholog1.71412447
25MP0008260_abnormal_autophagy1.70382262
26MP0000013_abnormal_adipose_tissue1.64899889
27MP0005330_cardiomyopathy1.61605860
28MP0004272_abnormal_basement_membrane1.60825624
29MP0003329_amyloid_beta_deposits1.60495266
30MP0008961_abnormal_basal_metabolism1.56879698
31MP0005670_abnormal_white_adipose1.53171146
32MP0004043_abnormal_pH_regulation1.51764828
33MP0009840_abnormal_foam_cell1.50806611
34MP0005257_abnormal_intraocular_pressure1.49692496
35MP0000750_abnormal_muscle_regeneration1.49171971
36MP0004858_abnormal_nervous_system1.48992266
37MP0002089_abnormal_postnatal_growth/wei1.48835996
38MP0000003_abnormal_adipose_tissue1.47589462
39MP0005623_abnormal_meninges_morphology1.47076691
40MP0001348_abnormal_lacrimal_gland1.46722912
41MP0005501_abnormal_skin_physiology1.45196764
42MP0005076_abnormal_cell_differentiation1.44716255
43MP0010030_abnormal_orbit_morphology1.44704038
44MP0005167_abnormal_blood-brain_barrier1.42068699
45MP0000749_muscle_degeneration1.41373388
46MP0002249_abnormal_larynx_morphology1.41311600
47MP0000733_abnormal_muscle_development1.40598982
48MP0000678_abnormal_parathyroid_gland1.36369471
49MP0003252_abnormal_bile_duct1.34788236
50MP0003283_abnormal_digestive_organ1.33568452
51MP0002909_abnormal_adrenal_gland1.32905698
52MP0010368_abnormal_lymphatic_system1.32676956
53MP0005083_abnormal_biliary_tract1.32431384
54MP0010329_abnormal_lipoprotein_level1.31968952
55MP0004036_abnormal_muscle_relaxation1.30752604
56MP0010630_abnormal_cardiac_muscle1.28641045
57MP0003172_abnormal_lysosome_physiology1.27516035
58MP0000858_altered_metastatic_potential1.26954804
59MP0005058_abnormal_lysosome_morphology1.25611375
60MP0000759_abnormal_skeletal_muscle1.25031657
61MP0010352_gastrointestinal_tract_polyps1.22219211
62MP0000747_muscle_weakness1.21620756
63MP0009384_cardiac_valve_regurgitation1.20670105
64MP0001849_ear_inflammation1.19515710
65MP0003646_muscle_fatigue1.18796355
66MP0003045_fibrosis1.18630323
67MP0002896_abnormal_bone_mineralization1.16204543
68MP0008775_abnormal_heart_ventricle1.14614276
69MP0009780_abnormal_chondrocyte_physiolo1.12192813
70MP0004947_skin_inflammation1.10983148
71MP0002972_abnormal_cardiac_muscle1.09095607
72MP0001544_abnormal_cardiovascular_syste1.08890793
73MP0005385_cardiovascular_system_phenoty1.08890793
74MP0002971_abnormal_brown_adipose1.08718371
75MP0005620_abnormal_muscle_contractility1.08222953
76MP0002269_muscular_atrophy1.07276269
77MP0005365_abnormal_bile_salt1.07226281
78MP0005367_renal/urinary_system_phenotyp1.07062617
79MP0000516_abnormal_urinary_system1.07062617
80MP0005085_abnormal_gallbladder_physiolo1.05892389
81MP0000467_abnormal_esophagus_morphology1.05474728
82MP0002060_abnormal_skin_morphology1.02950616
83MP0003091_abnormal_cell_migration1.02502563
84MP0009643_abnormal_urine_homeostasis1.01555035
85MP0002138_abnormal_hepatobiliary_system1.01506889
86MP0004381_abnormal_hair_follicle1.00975982
87MP0000579_abnormal_nail_morphology1.00663090
88MP0002998_abnormal_bone_remodeling1.00106121
89MP0000462_abnormal_digestive_system0.99228777
90MP0002118_abnormal_lipid_homeostasis0.98747078
91MP0004233_abnormal_muscle_weight0.98665520
92MP0009053_abnormal_anal_canal0.97916449
93MP0000537_abnormal_urethra_morphology0.97448371
94MP0001756_abnormal_urination0.97154382
95MP0000534_abnormal_ureter_morphology0.96613706
96MP0004215_abnormal_myocardial_fiber0.96066319
97MP0002796_impaired_skin_barrier0.95817059
98MP0005508_abnormal_skeleton_morphology0.95590716
99MP0009379_abnormal_foot_pigmentation0.95177308
100MP0003634_abnormal_glial_cell0.94908642
101MP0006138_congestive_heart_failure0.94343414
102MP0002106_abnormal_muscle_physiology0.94206530
103MP0003828_pulmonary_edema0.93077850
104MP0005332_abnormal_amino_acid0.92720932
105MP0003123_paternal_imprinting0.92580033
106MP0001216_abnormal_epidermal_layer0.92417279
107MP0000762_abnormal_tongue_morphology0.91827320
108MP0002234_abnormal_pharynx_morphology0.90311732
109MP0004510_myositis0.89505558
110MP0009278_abnormal_bone_marrow0.89245122
111MP0003075_altered_response_to0.88442964
112MP0000609_abnormal_liver_physiology0.88250020
113MP0005023_abnormal_wound_healing0.87848348
114MP0002098_abnormal_vibrissa_morphology0.87069562
115MP0005503_abnormal_tendon_morphology0.86833415
116MP0001243_abnormal_dermal_layer0.86787345
117MP0000604_amyloidosis0.85958145
118MP0008875_abnormal_xenobiotic_pharmacok0.85769989
119MP0005319_abnormal_enzyme/_coenzyme0.85340866
120MP0009115_abnormal_fat_cell0.83941794
121MP0001879_abnormal_lymphatic_vessel0.81616548
122MP0005621_abnormal_cell_physiology0.81554064
123MP0000681_abnormal_thyroid_gland0.81176981
124MP0009931_abnormal_skin_appearance0.80719030
125MP0006054_spinal_hemorrhage0.80514246
126MP0002970_abnormal_white_adipose0.79673307
127MP0000767_abnormal_smooth_muscle0.77779049
128MP0005369_muscle_phenotype0.77258955
129MP0001915_intracranial_hemorrhage0.76388956
130MP0002168_other_aberrant_phenotype0.75775719
131MP0003436_decreased_susceptibility_to0.75730361
132MP0005334_abnormal_fat_pad0.74904570
133MP0009672_abnormal_birth_weight0.74012636
134MP0010771_integument_phenotype0.73923112
135MP0001542_abnormal_bone_strength0.73264626
136MP0001666_abnormal_nutrient_absorption0.72839291
137MP0002128_abnormal_blood_circulation0.71833066
138MP0004264_abnormal_extraembryonic_tissu0.70533403
139MP0005390_skeleton_phenotype0.69408904
140MP0003448_altered_tumor_morphology0.69325890
141MP0000377_abnormal_hair_follicle0.67625828
142MP0002108_abnormal_muscle_morphology0.67545060
143MP0003942_abnormal_urinary_system0.67283447
144MP0004782_abnormal_surfactant_physiolog0.65331337
145MP0005165_increased_susceptibility_to0.65216550
146MP0003115_abnormal_respiratory_system0.65012344

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)3.59353560
2Protrusio acetabuli (HP:0003179)3.53613801
3Cerebral aneurysm (HP:0004944)3.43761405
4Premature rupture of membranes (HP:0001788)3.39172807
5Distal lower limb muscle weakness (HP:0009053)3.28215386
6Vertebral compression fractures (HP:0002953)3.24311085
7Shallow orbits (HP:0000586)3.11140452
8Hyperacusis (HP:0010780)3.04037016
9Right ventricular cardiomyopathy (HP:0011663)3.03656276
10Sudden death (HP:0001699)3.01064207
11Broad metatarsal (HP:0001783)2.98368511
12Type 1 muscle fiber predominance (HP:0003803)2.94346715
13Lymphangioma (HP:0100764)2.80353950
14Hyporeflexia of lower limbs (HP:0002600)2.78264063
15Difficulty running (HP:0009046)2.77954569
16Exercise-induced muscle cramps (HP:0003710)2.74726504
17Broad face (HP:0000283)2.73923024
18Achilles tendon contracture (HP:0001771)2.66297883
19Increased variability in muscle fiber diameter (HP:0003557)2.66191859
20Abnormality of the Achilles tendon (HP:0005109)2.64539056
21Asymmetric septal hypertrophy (HP:0001670)2.64289846
22Myoglobinuria (HP:0002913)2.60765444
23Obstructive sleep apnea (HP:0002870)2.58803146
24Exercise-induced myalgia (HP:0003738)2.58718401
25Ventricular tachycardia (HP:0004756)2.53938748
26Mitral valve prolapse (HP:0001634)2.50703976
27Mitral regurgitation (HP:0001653)2.48310433
28Ankle contracture (HP:0006466)2.46951441
29Insomnia (HP:0100785)2.46649301
30Difficulty climbing stairs (HP:0003551)2.46486065
31Muscle fiber splitting (HP:0003555)2.45791981
32Mildly elevated creatine phosphokinase (HP:0008180)2.45425160
33Asymmetry of the thorax (HP:0001555)2.42589175
34Abnormality of skeletal muscle fiber size (HP:0012084)2.39977100
35Aneurysm (HP:0002617)2.39062369
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.33356161
37Aortic dissection (HP:0002647)2.33035576
38Distal upper limb amyotrophy (HP:0007149)2.30502117
39Upper limb amyotrophy (HP:0009129)2.30502117
40Deep venous thrombosis (HP:0002625)2.27984347
41Bladder diverticulum (HP:0000015)2.24091748
42Short nail (HP:0001799)2.23935501
43Atrophic scars (HP:0001075)2.22752067
44Aortic aneurysm (HP:0004942)2.22119528
45Hyperparathyroidism (HP:0000843)2.20656259
46Thin bony cortex (HP:0002753)2.20549592
47Turricephaly (HP:0000262)2.18997600
48Generalized amyotrophy (HP:0003700)2.18788173
49J-shaped sella turcica (HP:0002680)2.18620585
50Ketoacidosis (HP:0001993)2.18608844
51Bundle branch block (HP:0011710)2.17776030
52Wormian bones (HP:0002645)2.15032298
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.13740198
54Osteolytic defects of the hand bones (HP:0009699)2.13740198
55Stridor (HP:0010307)2.12780773
56Disproportionate tall stature (HP:0001519)2.12779655
57Dilatation of the ascending aorta (HP:0005111)2.12237531
58Fragile skin (HP:0001030)2.11109271
59Scapular winging (HP:0003691)2.10437919
60Long toe (HP:0010511)2.10380173
61Conjunctival hamartoma (HP:0100780)2.08232497
62Elbow flexion contracture (HP:0002987)2.08018097
63Cerebral inclusion bodies (HP:0100314)2.07318789
64Distal lower limb amyotrophy (HP:0008944)2.06761720
65Vascular tortuosity (HP:0004948)2.06267130
66Peritonitis (HP:0002586)2.05481683
67Flat acetabular roof (HP:0003180)2.03114448
68Limb-girdle muscle atrophy (HP:0003797)2.01905228
69Arterial tortuosity (HP:0005116)2.01756282
70Hamartoma of the eye (HP:0010568)2.01752756
71Rectal prolapse (HP:0002035)1.98201262
72Spinal rigidity (HP:0003306)1.98127190
73Gout (HP:0001997)1.96256629
74Spinal cord compression (HP:0002176)1.95783526
75Hand muscle atrophy (HP:0009130)1.94366766
76Xanthomatosis (HP:0000991)1.94358911
77Polycythemia (HP:0001901)1.94053236
78Frequent falls (HP:0002359)1.93361674
79Abnormality of the distal phalanges of the toes (HP:0010182)1.92916543
80Biconcave vertebral bodies (HP:0004586)1.92911710
81Abnormality of the calf musculature (HP:0001430)1.91472621
82Enlarged penis (HP:0000040)1.91058964
83Genu recurvatum (HP:0002816)1.90571805
84EMG: myopathic abnormalities (HP:0003458)1.89531822
85Neurofibrillary tangles (HP:0002185)1.87481957
86Myopathic facies (HP:0002058)1.86326067
87Lower limb amyotrophy (HP:0007210)1.85828234
88Ketosis (HP:0001946)1.85518984
89Visceral angiomatosis (HP:0100761)1.84720031
90Myocardial infarction (HP:0001658)1.83344244
91Atrioventricular block (HP:0001678)1.82045147
92Ulnar bowing (HP:0003031)1.81602769
93Dysostosis multiplex (HP:0000943)1.81537832
94Subaortic stenosis (HP:0001682)1.81178792
95Abnormality of the left ventricular outflow tract (HP:0011103)1.81178792
96Abnormal atrioventricular conduction (HP:0005150)1.81071208
97Bronchomalacia (HP:0002780)1.80313728
98Back pain (HP:0003418)1.80051374
99Trismus (HP:0000211)1.79026404
100Cervical subluxation (HP:0003308)1.78639161
101Lipoatrophy (HP:0100578)1.78386471
102Long palpebral fissure (HP:0000637)1.77605474
103Advanced eruption of teeth (HP:0006288)1.77578761
104Renal duplication (HP:0000075)1.76445436
105Subacute progressive viral hepatitis (HP:0006572)1.76039789
106Bulbar palsy (HP:0001283)1.76012038
107Slender build (HP:0001533)1.74572122
108Nuclear cataract (HP:0100018)1.72985467
109Overriding aorta (HP:0002623)1.72703589
110Patellar dislocation (HP:0002999)1.72170821
111Round ear (HP:0100830)1.71841478
112Deviation of the hallux (HP:0010051)1.71241684
113Abnormal cartilage morphology (HP:0002763)1.71053127
114Striae distensae (HP:0001065)1.71005456
115Mesangial abnormality (HP:0001966)1.70505938
116Congenital glaucoma (HP:0001087)1.70189920
117Hypercortisolism (HP:0001578)1.70077766
118Bowed forearm bones (HP:0003956)1.69730300
119Bowing of the arm (HP:0006488)1.69730300
120Urinary glycosaminoglycan excretion (HP:0003541)1.69038066
121Mucopolysacchariduria (HP:0008155)1.69038066
122Hypoalphalipoproteinemia (HP:0003233)1.68425133
123Abnormality of the thoracic spine (HP:0100711)1.68357091
124Natal tooth (HP:0000695)1.68166127
125Hyperextensible skin (HP:0000974)1.67516088
126Hemangiomatosis (HP:0007461)1.67436546
127Hallux valgus (HP:0001822)1.67373832
128Calf muscle hypertrophy (HP:0008981)1.66576486
129Elfin facies (HP:0004428)1.65785364
130Abnormal ossification of hand bones (HP:0005921)1.64804752
131Syringomyelia (HP:0003396)1.64480311
132Spinal cord lesions (HP:0100561)1.64480311
133Hemorrhage of the eye (HP:0011885)1.63726908
134Foot dorsiflexor weakness (HP:0009027)1.63515799
135Abnormality of liposaccharide metabolism (HP:0010968)1.62845629
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.62845629
137Abnormality of glycolipid metabolism (HP:0010969)1.62845629
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.62781179
139Hypercalcemia (HP:0003072)1.62747105
140Heart block (HP:0012722)1.62638050
141Interstitial pulmonary disease (HP:0006530)1.62599315
142Blue sclerae (HP:0000592)1.62568660
143Acanthosis nigricans (HP:0000956)1.61929321
144Abnormality of glutamine family amino acid metabolism (HP:0010902)1.61900870
145Atrial fibrillation (HP:0005110)1.61476192
146Axonal loss (HP:0003447)1.60637402
147Ventricular arrhythmia (HP:0004308)1.60381948
148Hematochezia (HP:0002573)1.60342111
149Abnormality of proline metabolism (HP:0010907)1.60235054
150Hydroxyprolinuria (HP:0003080)1.60235054
151Arnold-Chiari malformation (HP:0002308)1.59652192
152Complement deficiency (HP:0004431)1.59647824
153Late onset (HP:0003584)1.58498398
154Wide anterior fontanel (HP:0000260)1.57430802
155Ventricular fibrillation (HP:0001663)1.57104574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.43391147
2PKN24.34810069
3TTN3.50457045
4IRAK33.17823868
5PRPF4B3.00570242
6SMG12.96894107
7RIPK12.77464641
8EPHA22.66248632
9ERN12.48866163
10NME22.25387071
11PDGFRA2.13705248
12PTK62.13382148
13LMTK21.90305081
14EEF2K1.90220152
15SIK11.87061101
16MAP3K101.85994697
17DDR21.79644411
18BMX1.62301671
19EPHB21.53306333
20ICK1.49947007
21LRRK21.48196250
22DMPK1.47602552
23BCKDK1.36942847
24TAOK21.34679303
25PRKD31.32997814
26PHKG21.31156520
27PHKG11.31156520
28CDK121.27596864
29TGFBR21.24109310
30EPHB11.22586321
31CAMK1D1.20287482
32ARAF1.19224392
33CAMKK11.15957382
34TAOK11.14917168
35ILK1.11460724
36LATS11.09947182
37MST1R1.09554571
38FER1.09127662
39PAK41.09028895
40LATS21.07793383
41RPS6KB21.04032689
42CAMK1G0.99575499
43KSR20.98545490
44RET0.97886558
45DAPK20.97806968
46MAP3K70.94721126
47IRAK20.94460391
48FGFR40.94436499
49PTK20.94188933
50NEK10.89615008
51MAP3K130.89525553
52PRKCH0.88335917
53MARK20.85043178
54PAK60.83617328
55PRKD10.83295737
56ALK0.83143830
57MAP3K20.82048673
58DAPK30.81738598
59MAP2K30.78850742
60PDGFRB0.78077219
61PAK20.77958618
62MAP3K90.75602377
63MTOR0.75432998
64DYRK1B0.75412962
65STK380.75226188
66TYRO30.73807532
67TESK20.73495418
68LIMK10.73041535
69CDK60.72947891
70PDPK10.71441786
71WNK40.71217732
72RPS6KL10.70971379
73RPS6KC10.70971379
74MOS0.69900790
75NTRK10.69796444
76BRAF0.68277091
77SCYL20.67591703
78NEK90.66658366
79PDK30.65412280
80PDK40.65412280
81TIE10.63111844
82MAP3K60.63041257
83MAP3K30.62862608
84MAP2K10.62781529
85PRKD20.62523741
86MAP3K80.61991840
87MAP3K110.61963225
88PTK2B0.61678290
89MAP2K20.60939221
90PIM20.59213307
91ROCK10.57971912
92MYLK0.57330589
93PAK30.57315113
94IRAK40.56899051
95JAK20.54847093
96MAP3K10.54446762
97CAMK2G0.52857267
98JAK10.52385716
99TBK10.51056260
100FGFR30.50777294
101MAPK110.50659563
102RPS6KA20.49803765
103OBSCN0.49597687
104MET0.48584803
105ABL20.47417843
106CDC42BPA0.46761405
107RPS6KA60.46702880
108SIK20.46616658
109PRKG20.46278365
110ROCK20.45007357
111CDK70.44811507
112CSK0.44432705
113PDK10.44008747
114MUSK0.42755265
115PRKAA10.42195437
116FGFR10.41159664
117MAPKAPK20.41107573
118AKT20.40553820
119ERBB20.40245089
120GSK3A0.40192230
121CAMK2B0.40081597
122CDK40.39823326
123SGK30.38646763
124FLT30.37835894
125WNK10.37831073
126HIPK20.37608808
127PRKAA20.37523791
128ZAP700.37110274
129TESK10.36471357
130RPS6KA10.36423351
131MAPK40.35992041
132MAPKAPK30.35477869
133MAPK120.35274622
134AURKA0.31768525
135CDK80.30874209

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.49731523
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46705917
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33297966
4Other glycan degradation_Homo sapiens_hsa005112.30213990
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19683671
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08320483
7Fatty acid degradation_Homo sapiens_hsa000712.06158462
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93640784
9Prion diseases_Homo sapiens_hsa050201.75714921
10PPAR signaling pathway_Homo sapiens_hsa033201.68473615
11Arginine biosynthesis_Homo sapiens_hsa002201.68424676
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62332058
13Notch signaling pathway_Homo sapiens_hsa043301.60060836
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59272111
15Propanoate metabolism_Homo sapiens_hsa006401.56826207
16Fatty acid metabolism_Homo sapiens_hsa012121.50682872
17Pentose phosphate pathway_Homo sapiens_hsa000301.48393077
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47138145
19Dilated cardiomyopathy_Homo sapiens_hsa054141.39455615
20Thyroid cancer_Homo sapiens_hsa052161.34042716
21Bile secretion_Homo sapiens_hsa049761.31748884
22Focal adhesion_Homo sapiens_hsa045101.31233326
23Fructose and mannose metabolism_Homo sapiens_hsa000511.31227915
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28063509
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.27535408
26Insulin resistance_Homo sapiens_hsa049311.26355362
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24861052
28ErbB signaling pathway_Homo sapiens_hsa040121.22180825
29Butanoate metabolism_Homo sapiens_hsa006501.20395896
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19422922
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16700903
32Carbon metabolism_Homo sapiens_hsa012001.15750588
33ECM-receptor interaction_Homo sapiens_hsa045121.14765082
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13250423
35Tryptophan metabolism_Homo sapiens_hsa003801.11241372
36Chronic myeloid leukemia_Homo sapiens_hsa052201.09948516
37Proteoglycans in cancer_Homo sapiens_hsa052051.08455528
38Bladder cancer_Homo sapiens_hsa052191.08320466
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.07714697
40Sulfur relay system_Homo sapiens_hsa041221.06396989
41Insulin signaling pathway_Homo sapiens_hsa049101.05549678
42B cell receptor signaling pathway_Homo sapiens_hsa046621.03548439
43Amoebiasis_Homo sapiens_hsa051461.03458268
44AMPK signaling pathway_Homo sapiens_hsa041521.02650033
45Glioma_Homo sapiens_hsa052141.02462073
46Lysine degradation_Homo sapiens_hsa003101.02460656
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.01803316
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00050812
49Starch and sucrose metabolism_Homo sapiens_hsa005000.97917445
50Vibrio cholerae infection_Homo sapiens_hsa051100.97153198
51mTOR signaling pathway_Homo sapiens_hsa041500.95815712
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94870247
53VEGF signaling pathway_Homo sapiens_hsa043700.92667815
54Fatty acid biosynthesis_Homo sapiens_hsa000610.92325931
55Hepatitis C_Homo sapiens_hsa051600.91607899
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90391809
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90339982
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.89881245
59Endocytosis_Homo sapiens_hsa041440.89732280
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89652761
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89414287
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89157361
63Protein digestion and absorption_Homo sapiens_hsa049740.89028311
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86998166
65MicroRNAs in cancer_Homo sapiens_hsa052060.86923502
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.86092382
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84364672
68Pyruvate metabolism_Homo sapiens_hsa006200.83865032
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83705749
70Gastric acid secretion_Homo sapiens_hsa049710.83650668
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83537510
72Osteoclast differentiation_Homo sapiens_hsa043800.83283614
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83068012
74Adherens junction_Homo sapiens_hsa045200.82841011
75Prostate cancer_Homo sapiens_hsa052150.82209231
76Endometrial cancer_Homo sapiens_hsa052130.82169568
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81752888
78beta-Alanine metabolism_Homo sapiens_hsa004100.81082626
79Caffeine metabolism_Homo sapiens_hsa002320.80934614
80Type II diabetes mellitus_Homo sapiens_hsa049300.80155793
81Fat digestion and absorption_Homo sapiens_hsa049750.79270563
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.79136845
83Long-term potentiation_Homo sapiens_hsa047200.79119295
84Apoptosis_Homo sapiens_hsa042100.78586138
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78317565
86Vitamin B6 metabolism_Homo sapiens_hsa007500.78056253
87Hepatitis B_Homo sapiens_hsa051610.77415824
88Melanogenesis_Homo sapiens_hsa049160.77156405
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77080304
90Non-small cell lung cancer_Homo sapiens_hsa052230.76624841
91Choline metabolism in cancer_Homo sapiens_hsa052310.76472828
92Colorectal cancer_Homo sapiens_hsa052100.75820460
93Glucagon signaling pathway_Homo sapiens_hsa049220.74157378
94Inositol phosphate metabolism_Homo sapiens_hsa005620.73786392
95Salmonella infection_Homo sapiens_hsa051320.73493008
96TNF signaling pathway_Homo sapiens_hsa046680.73037372
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71951169
98Shigellosis_Homo sapiens_hsa051310.71736356
99Complement and coagulation cascades_Homo sapiens_hsa046100.71598189
100Estrogen signaling pathway_Homo sapiens_hsa049150.71351794
101Melanoma_Homo sapiens_hsa052180.69485012
102Lysosome_Homo sapiens_hsa041420.69036938
103HTLV-I infection_Homo sapiens_hsa051660.68805885
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.68520434
105Tight junction_Homo sapiens_hsa045300.68062532
106Biosynthesis of amino acids_Homo sapiens_hsa012300.66209482
107Small cell lung cancer_Homo sapiens_hsa052220.66181712
108Glycerolipid metabolism_Homo sapiens_hsa005610.63834525
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62212335
110Viral myocarditis_Homo sapiens_hsa054160.62204350
111Viral carcinogenesis_Homo sapiens_hsa052030.61881169
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61195294
113Platelet activation_Homo sapiens_hsa046110.60763036
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.60525979
115Acute myeloid leukemia_Homo sapiens_hsa052210.60471970
116Staphylococcus aureus infection_Homo sapiens_hsa051500.60246585
117GnRH signaling pathway_Homo sapiens_hsa049120.57952240
118HIF-1 signaling pathway_Homo sapiens_hsa040660.56531609
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56360200
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55886665
121Pathways in cancer_Homo sapiens_hsa052000.55369675
122Renal cell carcinoma_Homo sapiens_hsa052110.54957960
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54726167
124Pancreatic cancer_Homo sapiens_hsa052120.54412168
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53525244
126Renin secretion_Homo sapiens_hsa049240.52175005
127Axon guidance_Homo sapiens_hsa043600.52154290
128Toxoplasmosis_Homo sapiens_hsa051450.51764038
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51637391
130Gap junction_Homo sapiens_hsa045400.51399342
131MAPK signaling pathway_Homo sapiens_hsa040100.51325032
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.50182546
133Rap1 signaling pathway_Homo sapiens_hsa040150.49617752
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49285427
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48831162
136Prolactin signaling pathway_Homo sapiens_hsa049170.48770965
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48739677
138Galactose metabolism_Homo sapiens_hsa000520.48623092
139Hippo signaling pathway_Homo sapiens_hsa043900.48115824
140Thyroid hormone synthesis_Homo sapiens_hsa049180.47707553
141Oxytocin signaling pathway_Homo sapiens_hsa049210.47130968
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46709495
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45966468
144Sulfur metabolism_Homo sapiens_hsa009200.44072595
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43393368

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