ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	7.00807581
2	cilium movement (GO:0003341)	6.15640326
3	epithelial cilium movement (GO:0003351)	6.14814383
4	cilium or flagellum-dependent cell motility (GO:0001539)	6.04294892
5	regulation of cilium movement (GO:0003352)	6.00879375
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.56057906
7	axoneme assembly (GO:0035082)	5.43660176
8	protein neddylation (GO:0045116)	5.16628350
9	motile cilium assembly (GO:0044458)	4.42597781
10	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.25900775
11	intraciliary transport (GO:0042073)	4.10181027
12	left/right pattern formation (GO:0060972)	4.06751848
13	protein localization to cilium (GO:0061512)	3.98348093
14	peptidyl-histidine modification (GO:0018202)	3.95434590
15	cilium morphogenesis (GO:0060271)	3.83619993
16	respiratory chain complex IV assembly (GO:0008535)	3.73791695
17	cilium organization (GO:0044782)	3.70925386
18	regulation of microtubule-based movement (GO:0060632)	3.68903923
19	protein complex biogenesis (GO:0070271)	3.67808325
20	protein-cofactor linkage (GO:0018065)	3.65899996
21	cilium assembly (GO:0042384)	3.65369034
22	proteasome assembly (GO:0043248)	3.62498861
23	sequestering of actin monomers (GO:0042989)	3.61933972
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.60901744
25	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.60901744
26	nonmotile primary cilium assembly (GO:0035058)	3.56971960
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.50010017
28	microtubule bundle formation (GO:0001578)	3.48926822
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.47516614
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.47516614
31	NADH dehydrogenase complex assembly (GO:0010257)	3.47516614
32	DNA deamination (GO:0045006)	3.42285149
33	left/right axis specification (GO:0070986)	3.39828469
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.39439995
35	amino acid salvage (GO:0043102)	3.38614188
36	L-methionine salvage (GO:0071267)	3.38614188
37	L-methionine biosynthetic process (GO:0071265)	3.38614188
38	platelet dense granule organization (GO:0060155)	3.34515627
39	preassembly of GPI anchor in ER membrane (GO:0016254)	3.32939240
40	cytochrome complex assembly (GO:0017004)	3.30973380
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30057360
42	aldehyde catabolic process (GO:0046185)	3.29950887
43	nucleoside diphosphate phosphorylation (GO:0006165)	3.26375125
44	mannosylation (GO:0097502)	3.17582238
45	negative regulation of mast cell activation (GO:0033004)	3.15494061
46	GTP biosynthetic process (GO:0006183)	3.07951117
47	chaperone-mediated protein transport (GO:0072321)	3.03201434
48	termination of RNA polymerase III transcription (GO:0006386)	2.99598798
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.99598798
50	base-excision repair, AP site formation (GO:0006285)	2.92397238
51	behavioral response to nicotine (GO:0035095)	2.91180188
52	L-fucose catabolic process (GO:0042355)	2.90902971
53	fucose catabolic process (GO:0019317)	2.90902971
54	L-fucose metabolic process (GO:0042354)	2.90902971
55	rRNA catabolic process (GO:0016075)	2.90253027
56	cellular component assembly involved in morphogenesis (GO:0010927)	2.88937228
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.87920432
58	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.87133282
59	protein polyglutamylation (GO:0018095)	2.85828589
60	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.85613394
61	C-terminal protein amino acid modification (GO:0018410)	2.79360947
62	C-terminal protein lipidation (GO:0006501)	2.77440564
63	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.76400610
64	adenosine metabolic process (GO:0046085)	2.74565967
65	electron transport chain (GO:0022900)	2.73615598
66	negative regulation of appetite (GO:0032099)	2.71855345
67	negative regulation of response to food (GO:0032096)	2.71855345
68	protein K6-linked ubiquitination (GO:0085020)	2.71493647
69	GPI anchor metabolic process (GO:0006505)	2.70422030
70	smoothened signaling pathway (GO:0007224)	2.69383631
71	pseudouridine synthesis (GO:0001522)	2.69241241
72	anterograde synaptic vesicle transport (GO:0048490)	2.68143165
73	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.66308152
74	ATP synthesis coupled proton transport (GO:0015986)	2.66308152
75	respiratory electron transport chain (GO:0022904)	2.64949957
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.64302019
77	metallo-sulfur cluster assembly (GO:0031163)	2.64247552
78	iron-sulfur cluster assembly (GO:0016226)	2.64247552
79	regulation of action potential (GO:0098900)	2.63817447
80	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.63600477
81	ATP hydrolysis coupled proton transport (GO:0015991)	2.63600477
82	glutathione derivative biosynthetic process (GO:1901687)	2.63180983
83	glutathione derivative metabolic process (GO:1901685)	2.63180983
84	proton transport (GO:0015992)	2.62944970
85	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62930268
86	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.59122798
87	hydrogen transport (GO:0006818)	2.57390643
88	photoreceptor cell maintenance (GO:0045494)	2.56655784
89	protein deneddylation (GO:0000338)	2.56343277
90	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.55829624
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.54917016
92	hydrogen ion transmembrane transport (GO:1902600)	2.54270860
93	retinal cone cell development (GO:0046549)	2.53135797
94	DNA double-strand break processing (GO:0000729)	2.52798468
95	regulation of appetite (GO:0032098)	2.52107699
96	nucleotide transmembrane transport (GO:1901679)	2.50016345
97	serotonin receptor signaling pathway (GO:0007210)	2.49305254
98	amine catabolic process (GO:0009310)	2.49032348
99	cellular biogenic amine catabolic process (GO:0042402)	2.49032348
100	regulation of memory T cell differentiation (GO:0043380)	2.48835966

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.62699847
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45061446
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44746973
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22326142
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.17896325
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09856888
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.97544989
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.77830580
9	VDR_22108803_ChIP-Seq_LS180_Human	2.59042662
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29025235
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.27617981
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26643116
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15020791
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.11189283
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04047624
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.99180949
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.98650045
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.91930056
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91068957
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.91056346
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85005325
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80961655
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66340294
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.65035385
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65005236
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62245483
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61698271
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.57445910
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54641444
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52941859
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.51924929
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.51455578
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50540186
34	EWS_26573619_Chip-Seq_HEK293_Human	1.47506883
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.44633889
36	AR_20517297_ChIP-Seq_VCAP_Human	1.43518935
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41908849
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41637400
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41059104
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38644700
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38136440
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37341995
43	P300_19829295_ChIP-Seq_ESCs_Human	1.34548626
44	DCP1A_22483619_ChIP-Seq_HELA_Human	1.34086447
45	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31564384
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30542553
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29005052
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29005052
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26915102
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.26915102
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.25377179
52	NCOR_22424771_ChIP-Seq_293T_Human	1.20504738
53	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.18868331
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18227537
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17186492
56	STAT1_20625510_ChIP-Seq_HELA_Human	1.13482885
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.12266952
58	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.12039601
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.10583966
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.08844451
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06960193
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06960193
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.05934578
64	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.05374323
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04988798
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03218553
67	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03030243
68	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.02907707
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02731667
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01966402
71	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00918377
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.00428497
73	FUS_26573619_Chip-Seq_HEK293_Human	0.99942095
74	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.99669965
75	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.98428602
76	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.97925388
77	REST_21632747_ChIP-Seq_MESCs_Mouse	0.97844640
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96835080
79	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96768824
80	ERA_21632823_ChIP-Seq_H3396_Human	0.93781977
81	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.92669878
82	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92495452
83	PHF8_20622853_ChIP-Seq_HELA_Human	0.92375659
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91310010
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.90743929
86	AR_25329375_ChIP-Seq_VCAP_Human	0.90629662
87	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89331325
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88850899
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.88593861
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.88581919
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87880821
92	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.87880821
93	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87837616
94	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85472449
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85157459
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84609133
97	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.83895288
98	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.83731452
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.83591975
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.82402659

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.66195450
2	MP0003880_abnormal_central_pattern	3.27213086
3	MP0001968_abnormal_touch/_nociception	3.13664556
4	MP0001529_abnormal_vocalization	3.00242874
5	MP0001984_abnormal_olfaction	2.86270083
6	MP0008875_abnormal_xenobiotic_pharmacok	2.68957324
7	MP0002653_abnormal_ependyma_morphology	2.56344169
8	MP0008789_abnormal_olfactory_epithelium	2.44966521
9	MP0003011_delayed_dark_adaptation	2.39634409
10	MP0010386_abnormal_urinary_bladder	2.11287882
11	MP0001905_abnormal_dopamine_level	2.10098604
12	MP0009046_muscle_twitch	2.09774558
13	MP0005084_abnormal_gallbladder_morpholo	2.05251347
14	MP0002735_abnormal_chemical_nociception	2.01785275
15	MP0009745_abnormal_behavioral_response	1.92991684
16	MP0004133_heterotaxia	1.85758584
17	MP0002822_catalepsy	1.82542825
18	MP0005646_abnormal_pituitary_gland	1.80782985
19	MP0005394_taste/olfaction_phenotype	1.76221369
20	MP0005499_abnormal_olfactory_system	1.76221369
21	MP0005551_abnormal_eye_electrophysiolog	1.75867364
22	MP0002277_abnormal_respiratory_mucosa	1.74064326
23	MP0009780_abnormal_chondrocyte_physiolo	1.73586207
24	MP0006276_abnormal_autonomic_nervous	1.71612129
25	MP0008058_abnormal_DNA_repair	1.71405476
26	MP0002102_abnormal_ear_morphology	1.71111163
27	MP0003186_abnormal_redox_activity	1.69275040
28	MP0006072_abnormal_retinal_apoptosis	1.68290401
29	MP0001970_abnormal_pain_threshold	1.67776098
30	MP0008872_abnormal_physiological_respon	1.62818111
31	MP0002938_white_spotting	1.62124947
32	MP0005083_abnormal_biliary_tract	1.60518495
33	MP0004142_abnormal_muscle_tone	1.58675778
34	MP0005253_abnormal_eye_physiology	1.58275800
35	MP0000372_irregular_coat_pigmentation	1.49008965
36	MP0002572_abnormal_emotion/affect_behav	1.48837597
37	MP0005645_abnormal_hypothalamus_physiol	1.47521063
38	MP0003787_abnormal_imprinting	1.47372504
39	MP0002734_abnormal_mechanical_nocicepti	1.43836980
40	MP0006036_abnormal_mitochondrial_physio	1.33752369
41	MP0002272_abnormal_nervous_system	1.32097038
42	MP0003195_calcinosis	1.30132203
43	MP0010030_abnormal_orbit_morphology	1.30019125
44	MP0002282_abnormal_trachea_morphology	1.28666444
45	MP0000631_abnormal_neuroendocrine_gland	1.27299789
46	MP0001501_abnormal_sleep_pattern	1.25994172
47	MP0003718_maternal_effect	1.25552642
48	MP0005171_absent_coat_pigmentation	1.24019765
49	MP0002064_seizures	1.22892422
50	MP0001486_abnormal_startle_reflex	1.22648400
51	MP0002733_abnormal_thermal_nociception	1.17250469
52	MP0008877_abnormal_DNA_methylation	1.16125624
53	MP0006035_abnormal_mitochondrial_morpho	1.15820242
54	MP0001764_abnormal_homeostasis	1.15080043
55	MP0002557_abnormal_social/conspecific_i	1.14217060
56	MP0002234_abnormal_pharynx_morphology	1.12083170
57	MP0004885_abnormal_endolymph	1.10404552
58	MP0004147_increased_porphyrin_level	1.08753895
59	MP0005410_abnormal_fertilization	1.07594343
60	MP0003635_abnormal_synaptic_transmissio	1.07261104
61	MP0002067_abnormal_sensory_capabilities	1.06889378
62	MP0005174_abnormal_tail_pigmentation	1.06453841
63	MP0002876_abnormal_thyroid_physiology	1.05297264
64	MP0003806_abnormal_nucleotide_metabolis	1.04583881
65	MP0003136_yellow_coat_color	1.02731476
66	MP0002063_abnormal_learning/memory/cond	1.02189504
67	MP0001986_abnormal_taste_sensitivity	1.01567455
68	MP0002132_abnormal_respiratory_system	1.01188525
69	MP0002928_abnormal_bile_duct	1.00244917
70	MP0000358_abnormal_cell_content/	0.99240559
71	MP0000538_abnormal_urinary_bladder	0.98972443
72	MP0005464_abnormal_platelet_physiology	0.98898080
73	MP0000230_abnormal_systemic_arterial	0.97899677
74	MP0003786_premature_aging	0.96316748
75	MP0000343_altered_response_to	0.90184254
76	MP0001293_anophthalmia	0.90168685
77	MP0002751_abnormal_autonomic_nervous	0.86300472
78	MP0002295_abnormal_pulmonary_circulatio	0.85940866
79	MP0000516_abnormal_urinary_system	0.84273709
80	MP0005367_renal/urinary_system_phenotyp	0.84273709
81	MP0000427_abnormal_hair_cycle	0.83397519
82	MP0000026_abnormal_inner_ear	0.82709827
83	MP0005389_reproductive_system_phenotype	0.80604490
84	MP0005395_other_phenotype	0.80568244
85	MP0009764_decreased_sensitivity_to	0.77487889
86	MP0002752_abnormal_somatic_nervous	0.75544239
87	MP0006292_abnormal_olfactory_placode	0.75118670
88	MP0001485_abnormal_pinna_reflex	0.72830941
89	MP0000778_abnormal_nervous_system	0.71927366
90	MP0005386_behavior/neurological_phenoty	0.71031039
91	MP0004924_abnormal_behavior	0.71031039
92	MP0003698_abnormal_male_reproductive	0.70992209
93	MP0002168_other_aberrant_phenotype	0.70644808
94	MP0002229_neurodegeneration	0.70626866
95	MP0004859_abnormal_synaptic_plasticity	0.70217549
96	MP0001756_abnormal_urination	0.70170699
97	MP0001963_abnormal_hearing_physiology	0.70035822
98	MP0008873_increased_physiological_sensi	0.68565287
99	MP0005195_abnormal_posterior_eye	0.67872168
100	MP0004043_abnormal_pH_regulation	0.67748181

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.45467411
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.11287372
3	Absent/shortened dynein arms (HP:0200106)	6.11287372
4	Abnormal respiratory epithelium morphology (HP:0012253)	6.07668037
5	Abnormal respiratory motile cilium morphology (HP:0005938)	6.07668037
6	Abnormal respiratory motile cilium physiology (HP:0012261)	5.96763238
7	Abnormal ciliary motility (HP:0012262)	5.87010057
8	Rhinitis (HP:0012384)	5.37079126
9	True hermaphroditism (HP:0010459)	4.42608574
10	Pancreatic fibrosis (HP:0100732)	4.35786528
11	Pancreatic cysts (HP:0001737)	4.33202372
12	Molar tooth sign on MRI (HP:0002419)	4.12719330
13	Abnormality of midbrain morphology (HP:0002418)	4.12719330
14	Chronic bronchitis (HP:0004469)	4.06224933
15	Medial flaring of the eyebrow (HP:0010747)	3.75584292
16	Nephronophthisis (HP:0000090)	3.51257705
17	Bronchiectasis (HP:0002110)	3.42995239
18	3-Methylglutaconic aciduria (HP:0003535)	3.35744395
19	Acute necrotizing encephalopathy (HP:0006965)	3.27350728
20	Mitochondrial inheritance (HP:0001427)	3.24413307
21	Gait imbalance (HP:0002141)	3.13600167
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.06831431
23	Congenital primary aphakia (HP:0007707)	3.06028672
24	Renal Fanconi syndrome (HP:0001994)	2.87521399
25	Cystic liver disease (HP:0006706)	2.87432745
26	Increased CSF lactate (HP:0002490)	2.85288296
27	Progressive macrocephaly (HP:0004481)	2.85030632
28	Nephrogenic diabetes insipidus (HP:0009806)	2.82568869
29	Sclerocornea (HP:0000647)	2.81894001
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.81028149
31	Hepatocellular necrosis (HP:0001404)	2.80662343
32	Acute encephalopathy (HP:0006846)	2.79798757
33	Abnormality of the renal medulla (HP:0100957)	2.72140860
34	Postaxial foot polydactyly (HP:0001830)	2.71016945
35	Lipid accumulation in hepatocytes (HP:0006561)	2.59115346
36	Increased hepatocellular lipid droplets (HP:0006565)	2.58292092
37	Hepatic necrosis (HP:0002605)	2.58212329
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.56574126
39	Occipital encephalocele (HP:0002085)	2.53664044
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.47569705
41	Congenital hepatic fibrosis (HP:0002612)	2.46930544
42	Anencephaly (HP:0002323)	2.29762454
43	Median cleft lip (HP:0000161)	2.29346973
44	Genital tract atresia (HP:0001827)	2.28132506
45	Male pseudohermaphroditism (HP:0000037)	2.22798667
46	Postaxial hand polydactyly (HP:0001162)	2.21767757
47	Vaginal atresia (HP:0000148)	2.20161624
48	Attenuation of retinal blood vessels (HP:0007843)	2.16711807
49	Chronic hepatic failure (HP:0100626)	2.12085788
50	Pendular nystagmus (HP:0012043)	2.11181413
51	Abnormal number of erythroid precursors (HP:0012131)	2.11133790
52	Increased corneal curvature (HP:0100692)	2.10231113
53	Keratoconus (HP:0000563)	2.10231113
54	Infertility (HP:0000789)	2.09670633
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08800692
56	Decreased central vision (HP:0007663)	2.07084800
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.04495980
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.04495980
59	Abnormal protein glycosylation (HP:0012346)	2.04495980
60	Abnormal glycosylation (HP:0012345)	2.04495980
61	Progressive microcephaly (HP:0000253)	2.04460651
62	Abnormality of the renal cortex (HP:0011035)	2.04196981
63	Poor head control (HP:0002421)	2.03990687
64	Nasal polyposis (HP:0100582)	2.03844914
65	Optic disc pallor (HP:0000543)	2.02591614
66	Severe visual impairment (HP:0001141)	2.00636640
67	Exertional dyspnea (HP:0002875)	1.99419679
68	Type I transferrin isoform profile (HP:0003642)	1.99286853
69	Oculomotor apraxia (HP:0000657)	1.98824028
70	Delayed gross motor development (HP:0002194)	1.97894934
71	Preaxial hand polydactyly (HP:0001177)	1.92842810
72	Increased serum lactate (HP:0002151)	1.92104964
73	Abolished electroretinogram (ERG) (HP:0000550)	1.92050180
74	Furrowed tongue (HP:0000221)	1.91488240
75	Chronic sinusitis (HP:0011109)	1.89171821
76	Polydipsia (HP:0001959)	1.88328173
77	Abnormal drinking behavior (HP:0030082)	1.88328173
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88247242
79	Lactic acidosis (HP:0003128)	1.86371089
80	Cerebral edema (HP:0002181)	1.85573729
81	Nephropathy (HP:0000112)	1.79317305
82	Methylmalonic acidemia (HP:0002912)	1.78383021
83	Retinitis pigmentosa (HP:0000510)	1.75057173
84	Hemiparesis (HP:0001269)	1.73634913
85	Tubular atrophy (HP:0000092)	1.72012797
86	Methylmalonic aciduria (HP:0012120)	1.71018736
87	Polyphagia (HP:0002591)	1.70579823
88	Respiratory failure (HP:0002878)	1.70257604
89	Aganglionic megacolon (HP:0002251)	1.69804482
90	Abnormality of the nasal mucosa (HP:0000433)	1.69463177
91	Large for gestational age (HP:0001520)	1.69292360
92	Exercise intolerance (HP:0003546)	1.68263903
93	Decreased testicular size (HP:0008734)	1.66836188
94	Hypoplastic pelvis (HP:0008839)	1.64921246
95	Atelectasis (HP:0100750)	1.64801501
96	Poor coordination (HP:0002370)	1.63464376
97	Type II lissencephaly (HP:0007260)	1.62919976
98	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.61610876
99	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.61610876
100	Disproportionate short-trunk short stature (HP:0003521)	1.60574512

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.76590896
2	FRK	3.61265211
3	MST4	3.07046079
4	WNK3	2.87821977
5	ZAK	2.60266660
6	BCKDK	2.54539744
7	MAPK15	2.30189048
8	CDK19	2.27641161
9	TRIM28	2.22359124
10	TLK1	2.11978356
11	VRK2	2.08526936
12	ADRBK2	2.07871886
13	BMPR1B	2.04337574
14	GRK1	1.96249425
15	PINK1	1.94167518
16	NUAK1	1.83266499
17	DYRK2	1.82014283
18	MAP2K7	1.72411519
19	VRK1	1.68547646
20	EIF2AK3	1.64586272
21	EPHA4	1.63382973
22	EIF2AK1	1.59595787
23	STK16	1.55216161
24	LIMK1	1.53825373
25	TAOK3	1.53814821
26	PTK2B	1.47660304
27	TXK	1.47558933
28	PAK3	1.42358189
29	MAP3K12	1.41002421
30	BUB1	1.33520879
31	OXSR1	1.33319650
32	MAPK13	1.31084465
33	PIM2	1.28873340
34	CSNK1G3	1.23211104
35	CSNK1G2	1.20188087
36	MARK1	1.19626609
37	DAPK2	1.16791082
38	FLT3	1.16612195
39	PLK3	1.16567008
40	DYRK3	1.16520969
41	MAP3K4	1.11680064
42	EPHB2	1.11177474
43	CASK	1.06126386
44	BCR	1.03873845
45	PLK2	1.00280789
46	PHKG2	0.98741503
47	PHKG1	0.98741503
48	FER	0.97793330
49	CSNK1G1	0.95691112
50	PAK6	0.93372122
51	MUSK	0.91427829
52	MYLK	0.90399936
53	PNCK	0.89849092
54	PRKCG	0.87220100
55	ADRBK1	0.86324822
56	IRAK1	0.83019786
57	PRKCE	0.81186624
58	INSRR	0.80470443
59	NEK1	0.77032324
60	CCNB1	0.76276058
61	EPHA3	0.75219474
62	PKN1	0.74970354
63	IKBKB	0.72885404
64	ABL2	0.71336377
65	MINK1	0.70784452
66	CSNK1A1L	0.67035741
67	IRAK2	0.62974686
68	DAPK1	0.61860157
69	ILK	0.58429876
70	NTRK3	0.58113397
71	TSSK6	0.56114101
72	TGFBR1	0.55005641
73	TESK2	0.54872549
74	MAPKAPK3	0.54655849
75	PRKCI	0.54136037
76	TESK1	0.47570609
77	FES	0.47179223
78	ERBB3	0.46506465
79	TNIK	0.46343451
80	RPS6KA5	0.45023148
81	DAPK3	0.44983603
82	TIE1	0.43978647
83	PAK1	0.42175174
84	NME1	0.40493893
85	ACVR1B	0.39916963
86	GRK6	0.37780888
87	CAMK1	0.37372157
88	SRPK1	0.37249501
89	MARK3	0.35770840
90	PLK1	0.35172179
91	CAMK2A	0.34307371
92	GRK5	0.32219405
93	MAP2K4	0.30838278
94	AURKA	0.30311799
95	ROCK1	0.29480722
96	CSNK1A1	0.29111552
97	PRKCZ	0.28315493
98	TNK2	0.26984376
99	EIF2AK2	0.25446205
100	PRKCA	0.24746264

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.79188339
2	Proteasome_Homo sapiens_hsa03050	3.25123340
3	Parkinsons disease_Homo sapiens_hsa05012	2.98702811
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.93623295
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.83212991
6	Protein export_Homo sapiens_hsa03060	2.77526664
7	Huntingtons disease_Homo sapiens_hsa05016	2.61292579
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.60822720
9	RNA polymerase_Homo sapiens_hsa03020	2.55867644
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.22048763
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.20427570
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.09858447
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93539744
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.89306353
15	Phototransduction_Homo sapiens_hsa04744	1.89197841
16	Alzheimers disease_Homo sapiens_hsa05010	1.79268944
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68418732
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65306941
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.63270173
20	Glutathione metabolism_Homo sapiens_hsa00480	1.60267678
21	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.60170759
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59847590
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.59792868
24	Fatty acid elongation_Homo sapiens_hsa00062	1.58596813
25	Butanoate metabolism_Homo sapiens_hsa00650	1.57784427
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.52392745
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47740817
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46085621
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.44153608
30	Basal transcription factors_Homo sapiens_hsa03022	1.40381214
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40049064
32	Homologous recombination_Homo sapiens_hsa03440	1.34338313
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32137090
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.27217165
35	Base excision repair_Homo sapiens_hsa03410	1.26742769
36	Purine metabolism_Homo sapiens_hsa00230	1.20015344
37	Propanoate metabolism_Homo sapiens_hsa00640	1.18146237
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.14613192
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13735884
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.11644127
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.07471369
42	Regulation of autophagy_Homo sapiens_hsa04140	1.07232717
43	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.03949078
44	Peroxisome_Homo sapiens_hsa04146	1.03282185
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.02970120
46	Nicotine addiction_Homo sapiens_hsa05033	0.97188275
47	Metabolic pathways_Homo sapiens_hsa01100	0.93078856
48	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.92862366
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92463380
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.91936849
51	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.89759245
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88002029
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87440221
54	Mismatch repair_Homo sapiens_hsa03430	0.87314325
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86393270
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86046577
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80936328
58	Vibrio cholerae infection_Homo sapiens_hsa05110	0.79924920
59	RNA degradation_Homo sapiens_hsa03018	0.78650787
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76859305
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75015702
62	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.71613851
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70153940
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68808176
65	Olfactory transduction_Homo sapiens_hsa04740	0.68651511
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66971009
67	GABAergic synapse_Homo sapiens_hsa04727	0.65139327
68	Morphine addiction_Homo sapiens_hsa05032	0.63594866
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.62726127
70	Serotonergic synapse_Homo sapiens_hsa04726	0.59007957
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55762828
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.54987805
73	One carbon pool by folate_Homo sapiens_hsa00670	0.54577566
74	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53811205
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53693226
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52600814
77	Taste transduction_Homo sapiens_hsa04742	0.52222506
78	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.50184601
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49969959
80	Lysosome_Homo sapiens_hsa04142	0.49631384
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48934848
82	Ribosome_Homo sapiens_hsa03010	0.48091270
83	Salivary secretion_Homo sapiens_hsa04970	0.46721974
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45713668
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.44215762
86	Cocaine addiction_Homo sapiens_hsa05030	0.43208660
87	Circadian entrainment_Homo sapiens_hsa04713	0.41327282
88	Circadian rhythm_Homo sapiens_hsa04710	0.39691705
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.39058248
90	Caffeine metabolism_Homo sapiens_hsa00232	0.38567654
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36930719
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36139419
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35911856
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35291304
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33854542
96	RNA transport_Homo sapiens_hsa03013	0.33327945
97	Mineral absorption_Homo sapiens_hsa04978	0.32908318
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.32750005
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.32369278
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28236571

CENPBD1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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