CENPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)4.12225274
2centriole replication (GO:0007099)4.06827197
3monoubiquitinated protein deubiquitination (GO:0035520)3.98008860
4replication fork processing (GO:0031297)3.72554800
5DNA deamination (GO:0045006)3.68397731
6RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.59211007
7rRNA catabolic process (GO:0016075)3.56359779
8protein K6-linked ubiquitination (GO:0085020)3.53096843
9positive regulation of granulocyte differentiation (GO:0030854)3.52903245
10double-strand break repair via homologous recombination (GO:0000724)3.46729911
11recombinational repair (GO:0000725)3.45492937
12regulation of centriole replication (GO:0046599)3.40612538
13neural tube formation (GO:0001841)3.39134836
14prenylation (GO:0097354)3.34798846
15protein prenylation (GO:0018342)3.34798846
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.31275878
17L-fucose catabolic process (GO:0042355)3.29828454
18fucose catabolic process (GO:0019317)3.29828454
19L-fucose metabolic process (GO:0042354)3.29828454
20DNA double-strand break processing (GO:0000729)3.27660479
21reciprocal DNA recombination (GO:0035825)3.26062111
22reciprocal meiotic recombination (GO:0007131)3.26062111
23regulation of DNA endoreduplication (GO:0032875)3.26011288
24regulation of mitotic spindle checkpoint (GO:1903504)3.24445239
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24445239
26resolution of meiotic recombination intermediates (GO:0000712)3.22111394
27synapsis (GO:0007129)3.13272287
28* kinetochore organization (GO:0051383)3.10387546
29meiotic chromosome segregation (GO:0045132)3.09853865
30interkinetic nuclear migration (GO:0022027)3.08076661
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06944001
32isotype switching (GO:0045190)3.06944001
33somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06944001
34attachment of spindle microtubules to kinetochore (GO:0008608)3.05709342
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95834769
36histone mRNA catabolic process (GO:0071044)2.95798721
37microtubule anchoring (GO:0034453)2.92188541
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88986920
39mitotic sister chromatid cohesion (GO:0007064)2.87191419
40centrosome organization (GO:0051297)2.86552584
41negative T cell selection (GO:0043383)2.86442135
42protein K63-linked deubiquitination (GO:0070536)2.85429382
43negative thymic T cell selection (GO:0045060)2.81711592
44phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79715108
45microtubule organizing center organization (GO:0031023)2.78540788
46positive regulation of histone H3-K4 methylation (GO:0051571)2.78238472
47positive regulation of gamma-delta T cell activation (GO:0046645)2.76260748
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75994341
49mast cell degranulation (GO:0043303)2.74444365
50mast cell activation involved in immune response (GO:0002279)2.74444365
51centriole assembly (GO:0098534)2.74024323
52* kinetochore assembly (GO:0051382)2.73482705
53peptidyl-lysine trimethylation (GO:0018023)2.73385286
54histone H3-K4 trimethylation (GO:0080182)2.72270090
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72094472
56establishment of protein localization to Golgi (GO:0072600)2.71504897
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71339906
58somatic diversification of immune receptors (GO:0002200)2.66473824
59positive regulation of mRNA catabolic process (GO:0061014)2.65438753
60mitotic G2/M transition checkpoint (GO:0044818)2.65241063
61histone H2A acetylation (GO:0043968)2.64809387
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.63556885
63regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.63556885
64ncRNA catabolic process (GO:0034661)2.62594047
65somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.62111895
66somatic cell DNA recombination (GO:0016444)2.62111895
67regulation of centrosome duplication (GO:0010824)2.59133783
68cellular response to ethanol (GO:0071361)2.59117278
69somatic diversification of immunoglobulins (GO:0016445)2.56761622
70CENP-A containing nucleosome assembly (GO:0034080)2.55329116
71protein K48-linked deubiquitination (GO:0071108)2.54318138
72mitotic G2 DNA damage checkpoint (GO:0007095)2.54040634
73chromatin remodeling at centromere (GO:0031055)2.53659283
74double-strand break repair (GO:0006302)2.52466714
75piRNA metabolic process (GO:0034587)2.52172062
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.52111161
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52111161
78DNA ligation (GO:0006266)2.51024982
79regulation of centrosome cycle (GO:0046605)2.50624911
80microtubule depolymerization (GO:0007019)2.50594933
81axoneme assembly (GO:0035082)2.50447067
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50193677
83positive regulation of mitotic sister chromatid separation (GO:1901970)2.50193677
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50193677
85DNA demethylation (GO:0080111)2.49335428
86somatic recombination of immunoglobulin gene segments (GO:0016447)2.49236394
87sister chromatid cohesion (GO:0007062)2.49034069
88histone H3-K9 methylation (GO:0051567)2.48138595
89regulation of meiosis I (GO:0060631)2.46915984
90positive regulation of mRNA metabolic process (GO:1903313)2.46271768
91positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45519491
92regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45519491
93regulation of B cell receptor signaling pathway (GO:0050855)2.44486208
94sister chromatid segregation (GO:0000819)2.42584691
95DNA recombination (GO:0006310)2.42023012
96microtubule polymerization or depolymerization (GO:0031109)2.39617411
97cellular response to interleukin-15 (GO:0071350)2.39445003
98protein targeting to Golgi (GO:0000042)2.38119982
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.38059780
100regulation of gamma-delta T cell differentiation (GO:0045586)2.35384810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.18829882
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.97047615
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80306165
4ZNF274_21170338_ChIP-Seq_K562_Hela2.70510670
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66548208
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62958023
7VDR_22108803_ChIP-Seq_LS180_Human2.55015153
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.37194712
9IGF1R_20145208_ChIP-Seq_DFB_Human2.36793220
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35386499
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33922848
12EWS_26573619_Chip-Seq_HEK293_Human2.33205240
13E2F7_22180533_ChIP-Seq_HELA_Human2.24073733
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21522038
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21240292
16TAF15_26573619_Chip-Seq_HEK293_Human2.15618523
17FUS_26573619_Chip-Seq_HEK293_Human2.12821646
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08477566
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08075884
20ELK1_19687146_ChIP-ChIP_HELA_Human2.01883586
21GBX2_23144817_ChIP-Seq_PC3_Human1.98676343
22VDR_23849224_ChIP-Seq_CD4+_Human1.98358158
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.89764271
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83282019
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.79240676
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77453737
27ER_23166858_ChIP-Seq_MCF-7_Human1.77101715
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.75010959
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72644040
30P300_19829295_ChIP-Seq_ESCs_Human1.66284130
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62321523
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.62228573
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60019864
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59062529
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.57982057
36IRF1_19129219_ChIP-ChIP_H3396_Human1.57115589
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.57088427
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51228709
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50971505
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45572421
41FOXP3_21729870_ChIP-Seq_TREG_Human1.44916623
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43058516
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40646869
44CBP_20019798_ChIP-Seq_JUKART_Human1.37973271
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37973271
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.37343346
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36942403
48GATA1_22025678_ChIP-Seq_K562_Human1.35829655
49GATA3_26560356_Chip-Seq_TH2_Human1.35675046
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35138414
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34892683
52STAT3_23295773_ChIP-Seq_U87_Human1.32246665
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32222627
54BCAT_22108803_ChIP-Seq_LS180_Human1.30971029
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30952579
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30584721
57MYC_18940864_ChIP-ChIP_HL60_Human1.30402290
58MYB_26560356_Chip-Seq_TH2_Human1.29719114
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28371120
60SMAD4_21799915_ChIP-Seq_A2780_Human1.27939639
61TCF4_23295773_ChIP-Seq_U87_Human1.25362953
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24739815
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23220386
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22259439
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20300508
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.19906328
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.16532875
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14369366
69P53_22387025_ChIP-Seq_ESCs_Mouse1.12969079
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12228030
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11735516
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11499807
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10549091
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.10215889
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09825926
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09825926
77TP53_22573176_ChIP-Seq_HFKS_Human1.09814354
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09358743
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.08511708
80RUNX_20019798_ChIP-Seq_JUKART_Human1.08024990
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07498670
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07129711
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05372358
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04845208
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04604661
86TCF4_22108803_ChIP-Seq_LS180_Human1.04364521
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04190230
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04112793
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.03859555
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03624345
91NANOG_19829295_ChIP-Seq_ESCs_Human1.02393023
92SOX2_19829295_ChIP-Seq_ESCs_Human1.02393023
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.02364825
94GATA3_27048872_Chip-Seq_THYMUS_Human1.01510968
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01346591
96SALL4_22934838_ChIP-ChIP_CD34+_Human1.01080969
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00969835
98AR_25329375_ChIP-Seq_VCAP_Human1.00949178
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.00189633
100CDX2_22108803_ChIP-Seq_LS180_Human0.99121035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.62042899
2MP0000569_abnormal_digit_pigmentation4.03801838
3MP0008877_abnormal_DNA_methylation3.60332395
4MP0010094_abnormal_chromosome_stability3.14988776
5MP0005075_abnormal_melanosome_morpholog2.82824135
6MP0003787_abnormal_imprinting2.66083781
7MP0004147_increased_porphyrin_level2.58835773
8MP0000372_irregular_coat_pigmentation2.52395030
9MP0008058_abnormal_DNA_repair2.48798188
10MP0002009_preneoplasia2.47062057
11MP0005174_abnormal_tail_pigmentation2.29716660
12MP0002102_abnormal_ear_morphology1.97957692
13MP0003195_calcinosis1.94879327
14MP0003763_abnormal_thymus_physiology1.88437876
15MP0006072_abnormal_retinal_apoptosis1.87126189
16MP0005671_abnormal_response_to1.85182566
17MP0000427_abnormal_hair_cycle1.80675758
18MP0005646_abnormal_pituitary_gland1.75140125
19MP0002095_abnormal_skin_pigmentation1.74733065
20MP0000015_abnormal_ear_pigmentation1.68120370
21MP0003111_abnormal_nucleus_morphology1.67783438
22MP0001835_abnormal_antigen_presentation1.67184377
23MP0002396_abnormal_hematopoietic_system1.57594921
24MP0002166_altered_tumor_susceptibility1.53767671
25MP0008995_early_reproductive_senescence1.50959145
26MP0001800_abnormal_humoral_immune1.50060193
27MP0003786_premature_aging1.48920007
28MP0003718_maternal_effect1.48603013
29MP0000383_abnormal_hair_follicle1.44413373
30MP0005551_abnormal_eye_electrophysiolog1.41091942
31MP0005253_abnormal_eye_physiology1.36424005
32MP0003077_abnormal_cell_cycle1.33756710
33MP0003656_abnormal_erythrocyte_physiolo1.33601490
34MP0006292_abnormal_olfactory_placode1.22122145
35MP0003693_abnormal_embryo_hatching1.19991573
36MP0002006_tumorigenesis1.18340439
37MP0000689_abnormal_spleen_morphology1.16697412
38MP0001929_abnormal_gametogenesis1.15076881
39MP0003646_muscle_fatigue1.14618171
40MP0004885_abnormal_endolymph1.13876051
41MP0008872_abnormal_physiological_respon1.13838920
42MP0002398_abnormal_bone_marrow1.13546273
43MP0004043_abnormal_pH_regulation1.12714681
44MP0003724_increased_susceptibility_to1.11688971
45MP0002723_abnormal_immune_serum1.07361145
46MP0000703_abnormal_thymus_morphology1.07339333
47MP0002938_white_spotting1.05852292
48MP0002420_abnormal_adaptive_immunity1.04496287
49MP0001819_abnormal_immune_cell1.03427954
50MP0002452_abnormal_antigen_presenting1.03266908
51MP0004742_abnormal_vestibular_system1.01991042
52MP0002163_abnormal_gland_morphology1.01728113
53MP0005000_abnormal_immune_tolerance1.01132303
54MP0000371_diluted_coat_color1.01052127
55MP0005645_abnormal_hypothalamus_physiol1.00040430
56MP0005389_reproductive_system_phenotype0.99279412
57MP0001986_abnormal_taste_sensitivity0.99213000
58MP0009697_abnormal_copulation0.99125589
59MP0002722_abnormal_immune_system0.94643808
60MP0005310_abnormal_salivary_gland0.94183975
61MP0001501_abnormal_sleep_pattern0.93043744
62MP0010307_abnormal_tumor_latency0.91887598
63MP0003890_abnormal_embryonic-extraembry0.91289708
64MP0000716_abnormal_immune_system0.89853270
65MP0000653_abnormal_sex_gland0.89764178
66MP0002210_abnormal_sex_determination0.89745196
67MP0001119_abnormal_female_reproductive0.89370781
68MP0005397_hematopoietic_system_phenotyp0.87484440
69MP0001545_abnormal_hematopoietic_system0.87484440
70MP0009046_muscle_twitch0.87211348
71MP0001919_abnormal_reproductive_system0.86244156
72MP0001145_abnormal_male_reproductive0.86090678
73MP0010678_abnormal_skin_adnexa0.85401690
74MP0001764_abnormal_homeostasis0.85233464
75MP0002876_abnormal_thyroid_physiology0.82634342
76MP0002638_abnormal_pupillary_reflex0.82307526
77MP0001485_abnormal_pinna_reflex0.82156087
78MP0000685_abnormal_immune_system0.80931231
79MP0002928_abnormal_bile_duct0.79370327
80MP0000631_abnormal_neuroendocrine_gland0.79027274
81MP0008007_abnormal_cellular_replicative0.78714849
82MP0004381_abnormal_hair_follicle0.78023582
83MP0002019_abnormal_tumor_incidence0.77917432
84MP0000465_gastrointestinal_hemorrhage0.77463894
85MP0004134_abnormal_chest_morphology0.77432266
86MP0003121_genomic_imprinting0.76700444
87MP0003866_abnormal_defecation0.76436532
88MP0005379_endocrine/exocrine_gland_phen0.76247954
89MP0005220_abnormal_exocrine_pancreas0.72845281
90MP0001324_abnormal_eye_pigmentation0.72606255
91MP0002693_abnormal_pancreas_physiology0.72212029
92MP0008775_abnormal_heart_ventricle0.72138990
93MP0003698_abnormal_male_reproductive0.71714205
94MP0001968_abnormal_touch/_nociception0.71516710
95MP0001486_abnormal_startle_reflex0.71209398
96MP0006036_abnormal_mitochondrial_physio0.70716309
97MP0001790_abnormal_immune_system0.70622871
98MP0005387_immune_system_phenotype0.70622871
99MP0002429_abnormal_blood_cell0.70509260
100MP0002837_dystrophic_cardiac_calcinosis0.70433165

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)3.52327248
2Thyroiditis (HP:0100646)3.50739051
3Volvulus (HP:0002580)3.40196662
4Abnormality of B cell number (HP:0010975)3.31595399
5B lymphocytopenia (HP:0010976)3.30363056
6Panhypogammaglobulinemia (HP:0003139)3.30240938
7IgG deficiency (HP:0004315)3.20959672
8Pancreatic cysts (HP:0001737)3.19076922
9Molar tooth sign on MRI (HP:0002419)3.17399122
10Abnormality of midbrain morphology (HP:0002418)3.17399122
11Stomach cancer (HP:0012126)3.07001544
12Abnormality of chromosome stability (HP:0003220)3.05983092
13Abnormality of the renal cortex (HP:0011035)3.01067446
14Combined immunodeficiency (HP:0005387)2.97476531
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94802349
16Chromsome breakage (HP:0040012)2.94439366
17Pancreatic fibrosis (HP:0100732)2.93215664
18Stomatitis (HP:0010280)2.91843331
19T lymphocytopenia (HP:0005403)2.88310446
20Abnormality of T cell number (HP:0011839)2.72520743
21Nephronophthisis (HP:0000090)2.69541673
22Gaze-evoked nystagmus (HP:0000640)2.65153620
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.62676016
24Renal cortical cysts (HP:0000803)2.61773123
25Abnormality of the renal medulla (HP:0100957)2.53574670
26Clubbing of toes (HP:0100760)2.53482458
27Abnormality of T cells (HP:0002843)2.47868259
28True hermaphroditism (HP:0010459)2.46705900
29Chronic hepatic failure (HP:0100626)2.43031813
30Sloping forehead (HP:0000340)2.40360870
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.37269381
32Abnormality of the ileum (HP:0001549)2.35049622
33IgM deficiency (HP:0002850)2.33404828
34Meckel diverticulum (HP:0002245)2.30013930
35Abnormality of eosinophils (HP:0001879)2.28007553
36Abnormality of T cell physiology (HP:0011840)2.25233494
37Medial flaring of the eyebrow (HP:0010747)2.19652590
38Colon cancer (HP:0003003)2.16543622
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.16535630
40Congenital stationary night blindness (HP:0007642)2.16011362
41Abnormality of the preputium (HP:0100587)2.14272450
42Fair hair (HP:0002286)2.13516669
43Neoplasm of the adrenal cortex (HP:0100641)2.13421267
44Abnormality of the labia minora (HP:0012880)2.13212846
45Duodenal stenosis (HP:0100867)2.12700471
46Small intestinal stenosis (HP:0012848)2.12700471
47Prostate neoplasm (HP:0100787)2.12171198
48Hypoplasia of the thymus (HP:0000778)2.10820896
49Hypoproteinemia (HP:0003075)2.05336223
50Abolished electroretinogram (ERG) (HP:0000550)2.05275605
51Attenuation of retinal blood vessels (HP:0007843)2.04881452
52Eosinophilia (HP:0001880)2.03526677
53Abnormality of the pons (HP:0007361)2.02369227
54Hyperventilation (HP:0002883)2.01082054
55Albinism (HP:0001022)2.01048860
56Widely spaced teeth (HP:0000687)1.98158462
57Acute myeloid leukemia (HP:0004808)1.97589853
58Tubulointerstitial nephritis (HP:0001970)1.95050587
59Abnormal biliary tract physiology (HP:0012439)1.94938558
60Bile duct proliferation (HP:0001408)1.94938558
61Myelodysplasia (HP:0002863)1.94330037
62Abnormality of the prostate (HP:0008775)1.94125562
63Short tibia (HP:0005736)1.93827698
64Abnormality of the duodenum (HP:0002246)1.91483490
65Hypothermia (HP:0002045)1.91329341
66Intestinal atresia (HP:0011100)1.86845023
67Recurrent bronchitis (HP:0002837)1.86658115
68Hypoplasia of the pons (HP:0012110)1.84282531
69Duplicated collecting system (HP:0000081)1.84277692
70Hematochezia (HP:0002573)1.83898532
71Recurrent fungal infections (HP:0002841)1.82765058
72Recurrent cutaneous fungal infections (HP:0011370)1.81901887
73Chronic mucocutaneous candidiasis (HP:0002728)1.81901887
74Neutropenia (HP:0001875)1.80502465
75Embryonal renal neoplasm (HP:0011794)1.79130501
76Postaxial foot polydactyly (HP:0001830)1.78912249
77Nephroblastoma (Wilms tumor) (HP:0002667)1.77957234
78Abnormality of the renal collecting system (HP:0004742)1.75986463
79Long clavicles (HP:0000890)1.75142979
80Abnormality of macular pigmentation (HP:0008002)1.74479130
81Oligodactyly (hands) (HP:0001180)1.74190912
82Generalized hypopigmentation of hair (HP:0011358)1.73999370
83Granulocytopenia (HP:0001913)1.73152981
84IgA deficiency (HP:0002720)1.73061608
85Abnormality of DNA repair (HP:0003254)1.69756777
86Ectopic kidney (HP:0000086)1.69498688
87Median cleft lip (HP:0000161)1.68601076
88Congenital primary aphakia (HP:0007707)1.68083438
89Methylmalonic acidemia (HP:0002912)1.67585330
90Birth length less than 3rd percentile (HP:0003561)1.65588559
91Febrile seizures (HP:0002373)1.61493253
92Agammaglobulinemia (HP:0004432)1.61468452
93Large for gestational age (HP:0001520)1.61458001
94Congenital hepatic fibrosis (HP:0002612)1.60219502
95Astigmatism (HP:0000483)1.59957552
96Progressive microcephaly (HP:0000253)1.59687108
97Progressive inability to walk (HP:0002505)1.59246609
98Limb hypertonia (HP:0002509)1.58920975
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.58353096
100Constricted visual fields (HP:0001133)1.58268767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.49625755
2FRK4.59813461
3MAP4K23.57736241
4NUAK12.70025795
5BMPR1B2.65908460
6BRSK22.35129703
7ZAK2.21138787
8ACVR1B2.19938431
9TXK2.08457521
10PLK41.82509532
11MST41.73696540
12MKNK21.73246623
13TEC1.73229620
14EIF2AK31.70625863
15WEE11.60612017
16NLK1.54800280
17TNIK1.46097683
18MAP3K41.45937758
19BUB11.38768943
20WNK31.35640316
21ERBB31.33065191
22MAPK131.28162410
23MKNK11.26557600
24CDC71.09717562
25CDK81.08644134
26ADRBK21.08466050
27BMPR21.04485989
28STK31.02380613
29VRK11.01444303
30GRK10.99687301
31TRIM280.99182441
32TTK0.97981611
33CCNB10.97558900
34OXSR10.97314608
35PLK30.97267251
36TNK20.94180612
37STK390.94132277
38PASK0.91238762
39PINK10.90643799
40ITK0.90296239
41SRPK10.89623604
42ATR0.87817498
43TGFBR10.85448684
44MARK30.84700482
45PLK20.83574129
46PIK3CG0.81409970
47EIF2AK20.80777108
48TLK10.80661902
49SYK0.78363817
50BTK0.76559800
51STK38L0.76113794
52CAMKK20.74064773
53WNK40.73649628
54BRD40.73113233
55IRAK10.70613044
56IKBKE0.68734700
57ATM0.68700392
58PLK10.68642369
59KIT0.67795756
60GRK60.66477573
61PRKCQ0.63773256
62PAK30.63305941
63EPHA30.63147634
64IKBKB0.61911014
65PIM10.60590506
66JAK10.60319374
67CHEK20.58596743
68LYN0.58364765
69CDK30.56862481
70NEK10.56439916
71PIK3CA0.56118994
72AKT30.53643166
73TRPM70.52774128
74INSRR0.52229999
75LCK0.51834838
76MAP4K10.47616786
77AURKB0.47362097
78CHEK10.46882125
79PRKCE0.45917316
80BLK0.44560617
81RPS6KA50.42800731
82NEK20.42588198
83STK100.41759553
84SGK20.41623984
85MAP3K140.40818738
86ERBB20.38504659
87JAK30.37812946
88CLK10.37310157
89MELK0.36367243
90LATS10.36341566
91FLT30.36135819
92CSNK1D0.35545689
93FES0.35338672
94RAF10.34880851
95FGFR20.34792130
96PKN10.34511670
97MAP2K20.32932506
98MAP2K60.32904540
99STK40.32487676
100PTK2B0.32420263

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.62728182
2Fanconi anemia pathway_Homo sapiens_hsa034603.32998174
3Non-homologous end-joining_Homo sapiens_hsa034503.20894420
4Primary immunodeficiency_Homo sapiens_hsa053403.13132724
5RNA degradation_Homo sapiens_hsa030182.35317475
6Basal transcription factors_Homo sapiens_hsa030222.28071990
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.20864629
8Mismatch repair_Homo sapiens_hsa034302.19270734
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94979586
10Phototransduction_Homo sapiens_hsa047441.85800031
11Asthma_Homo sapiens_hsa053101.85083930
12Protein export_Homo sapiens_hsa030601.81127386
13RNA polymerase_Homo sapiens_hsa030201.75340093
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.74112812
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61060123
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60068403
17DNA replication_Homo sapiens_hsa030301.59283358
18Autoimmune thyroid disease_Homo sapiens_hsa053201.56886807
19Allograft rejection_Homo sapiens_hsa053301.56711021
20Butanoate metabolism_Homo sapiens_hsa006501.56558518
21Nucleotide excision repair_Homo sapiens_hsa034201.53175272
22Type I diabetes mellitus_Homo sapiens_hsa049401.52789085
23Regulation of autophagy_Homo sapiens_hsa041401.45959156
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45771674
25Graft-versus-host disease_Homo sapiens_hsa053321.44939813
26Selenocompound metabolism_Homo sapiens_hsa004501.42756499
27Cell cycle_Homo sapiens_hsa041101.36500561
28Propanoate metabolism_Homo sapiens_hsa006401.34093269
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33928505
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32526364
31Nitrogen metabolism_Homo sapiens_hsa009101.32500626
32Spliceosome_Homo sapiens_hsa030401.30239830
33Circadian rhythm_Homo sapiens_hsa047101.27650725
34Base excision repair_Homo sapiens_hsa034101.24028194
35Linoleic acid metabolism_Homo sapiens_hsa005911.20073596
36RNA transport_Homo sapiens_hsa030131.19615042
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14156579
38p53 signaling pathway_Homo sapiens_hsa041151.10953835
39Systemic lupus erythematosus_Homo sapiens_hsa053221.09659720
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06537777
41T cell receptor signaling pathway_Homo sapiens_hsa046601.04271777
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03716633
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00696521
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.00313765
45Olfactory transduction_Homo sapiens_hsa047401.00137252
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99404187
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97234156
48Ether lipid metabolism_Homo sapiens_hsa005650.96315030
49Dorso-ventral axis formation_Homo sapiens_hsa043200.95805073
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95263126
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91876573
52Purine metabolism_Homo sapiens_hsa002300.90821108
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88789157
54Oocyte meiosis_Homo sapiens_hsa041140.87013579
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84984534
56Antigen processing and presentation_Homo sapiens_hsa046120.83468655
57Hematopoietic cell lineage_Homo sapiens_hsa046400.82912142
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81672955
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79168513
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78717920
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.78310000
62Pyrimidine metabolism_Homo sapiens_hsa002400.77107220
63Measles_Homo sapiens_hsa051620.76176382
64Herpes simplex infection_Homo sapiens_hsa051680.75739209
65ABC transporters_Homo sapiens_hsa020100.75402337
66One carbon pool by folate_Homo sapiens_hsa006700.75337827
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.74795694
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73969079
69Peroxisome_Homo sapiens_hsa041460.72308703
70mRNA surveillance pathway_Homo sapiens_hsa030150.70350179
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69135305
72Taste transduction_Homo sapiens_hsa047420.67198833
73Caffeine metabolism_Homo sapiens_hsa002320.66717558
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64278895
75Oxidative phosphorylation_Homo sapiens_hsa001900.61417543
76Tryptophan metabolism_Homo sapiens_hsa003800.57913562
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55096223
78Lysine degradation_Homo sapiens_hsa003100.53703818
79Nicotine addiction_Homo sapiens_hsa050330.49965020
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49741458
81Inositol phosphate metabolism_Homo sapiens_hsa005620.46146187
82Rheumatoid arthritis_Homo sapiens_hsa053230.46123438
83FoxO signaling pathway_Homo sapiens_hsa040680.45461714
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44525132
85Arachidonic acid metabolism_Homo sapiens_hsa005900.38177557
86Staphylococcus aureus infection_Homo sapiens_hsa051500.37030488
87Proteasome_Homo sapiens_hsa030500.36522034
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36389429
89Epstein-Barr virus infection_Homo sapiens_hsa051690.35192251
90Alcoholism_Homo sapiens_hsa050340.33322593
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33104093
92Huntingtons disease_Homo sapiens_hsa050160.32877128
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.32676727
94Parkinsons disease_Homo sapiens_hsa050120.32141009
95Retinol metabolism_Homo sapiens_hsa008300.31603504
96B cell receptor signaling pathway_Homo sapiens_hsa046620.31070914
97Leishmaniasis_Homo sapiens_hsa051400.29230029
98Chemical carcinogenesis_Homo sapiens_hsa052040.29167305
99Collecting duct acid secretion_Homo sapiens_hsa049660.28725023
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26903899

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