CENPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.91377254
2mitotic chromosome condensation (GO:0007076)5.44562781
3mitotic sister chromatid segregation (GO:0000070)5.36007553
4* kinetochore organization (GO:0051383)5.29766314
5protein localization to chromosome, centromeric region (GO:0071459)5.27969973
6nuclear pore complex assembly (GO:0051292)5.25700049
7sister chromatid segregation (GO:0000819)5.24782632
8regulation of spindle organization (GO:0090224)5.15340455
9nuclear pore organization (GO:0006999)5.13521675
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.09460637
11DNA ligation (GO:0006266)5.06755494
12* mitotic metaphase plate congression (GO:0007080)5.05080925
13attachment of spindle microtubules to kinetochore (GO:0008608)5.04041826
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.82145309
15regulation of mitotic spindle organization (GO:0060236)4.78843940
16* metaphase plate congression (GO:0051310)4.74247560
17mitotic sister chromatid cohesion (GO:0007064)4.59832039
18CENP-A containing nucleosome assembly (GO:0034080)4.57174703
19chromatin remodeling at centromere (GO:0031055)4.53628453
20meiotic chromosome segregation (GO:0045132)4.52167469
21mitotic nuclear envelope disassembly (GO:0007077)4.45292637
22* establishment of chromosome localization (GO:0051303)4.39831850
23positive regulation of chromosome segregation (GO:0051984)4.36671156
24positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.34064628
25positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.34064628
26positive regulation of mitotic sister chromatid separation (GO:1901970)4.34064628
27DNA replication-independent nucleosome assembly (GO:0006336)4.24442005
28DNA replication-independent nucleosome organization (GO:0034724)4.24442005
29spindle checkpoint (GO:0031577)4.24087223
30* kinetochore assembly (GO:0051382)4.22192596
31membrane disassembly (GO:0030397)4.14546189
32nuclear envelope disassembly (GO:0051081)4.14546189
33DNA unwinding involved in DNA replication (GO:0006268)4.14502368
34regulation of chromosome segregation (GO:0051983)4.10167560
35pore complex assembly (GO:0046931)4.07998288
36histone exchange (GO:0043486)4.07327558
37protein localization to chromosome (GO:0034502)4.04004987
38spindle assembly checkpoint (GO:0071173)3.97302662
39chromosome segregation (GO:0007059)3.96429642
40negative regulation of chromosome segregation (GO:0051985)3.89584602
41regulation of sister chromatid cohesion (GO:0007063)3.89454530
42DNA replication checkpoint (GO:0000076)3.89089046
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.85997776
44negative regulation of mitotic sister chromatid segregation (GO:0033048)3.85997776
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.85997776
46negative regulation of sister chromatid segregation (GO:0033046)3.85997776
47mitotic spindle checkpoint (GO:0071174)3.85949554
48DNA replication-dependent nucleosome organization (GO:0034723)3.84810474
49DNA replication-dependent nucleosome assembly (GO:0006335)3.84810474
50mitotic spindle assembly checkpoint (GO:0007094)3.82810898
51regulation of mitotic sister chromatid separation (GO:0010965)3.80265236
52regulation of mitotic sister chromatid segregation (GO:0033047)3.80265236
53regulation of sister chromatid segregation (GO:0033045)3.80265236
54* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.80016583
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.77663523
56regulation of centrosome cycle (GO:0046605)3.74431056
57* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.73565807
58chromosome condensation (GO:0030261)3.72935432
59microtubule depolymerization (GO:0007019)3.72574792
60replication fork processing (GO:0031297)3.72229804
61centriole replication (GO:0007099)3.71141333
62regulation of centriole replication (GO:0046599)3.68237541
63chromatin assembly or disassembly (GO:0006333)3.66854616
64DNA replication initiation (GO:0006270)3.59935645
65DNA double-strand break processing (GO:0000729)3.59861867
66DNA topological change (GO:0006265)3.59850704
67mitotic recombination (GO:0006312)3.57578015
68DNA strand elongation involved in DNA replication (GO:0006271)3.55952367
69establishment of integrated proviral latency (GO:0075713)3.52958227
70ventricular cardiac muscle cell development (GO:0055015)3.51855686
71mitotic G2 DNA damage checkpoint (GO:0007095)3.51801948
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47108392
73ATP-dependent chromatin remodeling (GO:0043044)3.44105785
74DNA packaging (GO:0006323)3.41410467
75DNA strand elongation (GO:0022616)3.38041454
76protein K6-linked ubiquitination (GO:0085020)3.37020235
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36798784
78regulation of mitotic spindle checkpoint (GO:1903504)3.36798784
79telomere maintenance via recombination (GO:0000722)3.34077287
80regulation of DNA endoreduplication (GO:0032875)3.31294130
81mitotic spindle organization (GO:0007052)3.30930104
82negative regulation of cell division (GO:0051782)3.30141287
83non-recombinational repair (GO:0000726)3.30059294
84double-strand break repair via nonhomologous end joining (GO:0006303)3.30059294
85DNA geometric change (GO:0032392)3.29785808
86telomere maintenance via semi-conservative replication (GO:0032201)3.29773016
87DNA duplex unwinding (GO:0032508)3.29418378
88histone-serine phosphorylation (GO:0035404)3.28100238
89microtubule polymerization or depolymerization (GO:0031109)3.27264333
90negative regulation of nuclear division (GO:0051784)3.26474635
91negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.24303723
92nuclear envelope organization (GO:0006998)3.22569914
93regulation of RNA export from nucleus (GO:0046831)3.19996278
94mitotic nuclear division (GO:0007067)3.19924303
95regulation of histone H3-K9 methylation (GO:0051570)3.19191047
96DNA conformation change (GO:0071103)3.18782274
97negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.17272023
98negative regulation of DNA-dependent DNA replication (GO:2000104)3.15773488
99negative regulation of DNA recombination (GO:0045910)3.13502994
100mitotic G2/M transition checkpoint (GO:0044818)3.12422180
101centrosome organization (GO:0051297)3.10921897
102regulation of centrosome duplication (GO:0010824)3.08636748
103regulation of spindle checkpoint (GO:0090231)3.08053624
104mitotic cytokinesis (GO:0000281)3.07204096
105heterochromatin organization (GO:0070828)3.06651592
106negative regulation of histone methylation (GO:0031061)2.99588583
107negative regulation of mitosis (GO:0045839)2.99518678
108pre-miRNA processing (GO:0031054)2.99256874
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96829495
110* mitotic cell cycle (GO:0000278)2.95673401
111telomere maintenance via telomere lengthening (GO:0010833)2.94076234
112sister chromatid cohesion (GO:0007062)2.93850645
113chromatin assembly (GO:0031497)2.93435304
114monoubiquitinated protein deubiquitination (GO:0035520)2.93133924
115regulation of double-strand break repair (GO:2000779)2.89448384
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.88345037
117* chromosome organization (GO:0051276)2.88160353
118mitotic DNA integrity checkpoint (GO:0044774)2.86793455
119resolution of meiotic recombination intermediates (GO:0000712)2.85795386
120mitotic cell cycle checkpoint (GO:0007093)2.83991866
121regulation of exit from mitosis (GO:0007096)2.83706268
122ribosome assembly (GO:0042255)2.82642769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.81702581
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.10361105
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.56328465
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41223058
5AR_21909140_ChIP-Seq_LNCAP_Human3.12464299
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.92868282
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74776328
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.74100662
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.55824591
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50997310
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47472887
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41899134
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36762933
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23156779
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23088588
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.22836569
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.20562799
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19854792
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02995946
20E2F7_22180533_ChIP-Seq_HELA_Human10.5461082
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96873995
22XRN2_22483619_ChIP-Seq_HELA_Human1.90564494
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87479052
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.87061199
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86507699
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84406740
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.83079178
28VDR_23849224_ChIP-Seq_CD4+_Human1.74456456
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.73099928
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65925517
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64093607
32EWS_26573619_Chip-Seq_HEK293_Human1.63530185
33ELK1_19687146_ChIP-ChIP_HELA_Human1.61309892
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60521453
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.60192462
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56229574
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55138052
38TTF2_22483619_ChIP-Seq_HELA_Human1.52827138
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51356269
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49823250
41CIITA_25753668_ChIP-Seq_RAJI_Human1.49263015
42DCP1A_22483619_ChIP-Seq_HELA_Human1.48556034
43KDM5A_27292631_Chip-Seq_BREAST_Human1.45192359
44MYC_22102868_ChIP-Seq_BL_Human1.44665671
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41612518
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39466657
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34233837
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33970478
49GABP_19822575_ChIP-Seq_HepG2_Human1.32544235
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31178809
51* FUS_26573619_Chip-Seq_HEK293_Human1.27282105
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25689232
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25565044
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25526813
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24600954
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23129520
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22437275
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18436252
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15774890
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12298657
61* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12265522
62VDR_22108803_ChIP-Seq_LS180_Human1.10725732
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09051585
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05293926
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05256751
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03970684
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03619848
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03243288
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02806659
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01341812
71NANOG_21062744_ChIP-ChIP_HESCs_Human0.99905149
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98653537
73POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98460356
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96628597
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96623990
76STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95029914
77TFEB_21752829_ChIP-Seq_HELA_Human0.95007265
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94883673
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93663374
80MYC_18940864_ChIP-ChIP_HL60_Human0.92794419
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92572435
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90992401
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90555873
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.89295516
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88516058
86ZNF274_21170338_ChIP-Seq_K562_Hela0.86735184
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85590066
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85019676
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85019676
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85019676
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84619323
92TAF15_26573619_Chip-Seq_HEK293_Human0.80042594
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79591441
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78487806
95SRF_21415370_ChIP-Seq_HL-1_Mouse0.77402239
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.77004550
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.76172386
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74997832
99CHD1_26751641_Chip-Seq_LNCaP_Human0.74195956
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73983706
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.73369483
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73335752
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.73143723
104YY1_21170310_ChIP-Seq_MESCs_Mouse0.72797571
105VDR_21846776_ChIP-Seq_THP-1_Human0.71584652
106IRF1_19129219_ChIP-ChIP_H3396_Human0.71260045
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.71184598
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69518256
109FOXM1_26456572_ChIP-Seq_MCF-7_Human0.68798124
110SOX2_16153702_ChIP-ChIP_HESCs_Human0.68152462
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67486188
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67439729
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67370723
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.67005683
115SPI1_23547873_ChIP-Seq_NB4_Human0.66975718
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.66759486
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65620146
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.65266716
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64853709
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.64756484
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63891183
122* SOX9_26525672_Chip-Seq_HEART_Mouse0.63686379
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63670620
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62662180
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.61921401
126P300_19829295_ChIP-Seq_ESCs_Human0.61891346
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.59829145
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.58612067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98749984
2MP0003111_abnormal_nucleus_morphology4.56427259
3* MP0010094_abnormal_chromosome_stability4.52910595
4* MP0003077_abnormal_cell_cycle3.94439562
5MP0008057_abnormal_DNA_replication3.86151215
6MP0004957_abnormal_blastocyst_morpholog3.81713505
7MP0008058_abnormal_DNA_repair2.88371942
8MP0008877_abnormal_DNA_methylation2.79084290
9MP0008007_abnormal_cellular_replicative2.78444324
10MP0003123_paternal_imprinting2.71776783
11MP0010307_abnormal_tumor_latency2.49168545
12MP0001730_embryonic_growth_arrest2.31915592
13* MP0008932_abnormal_embryonic_tissue2.27464310
14MP0000350_abnormal_cell_proliferation2.25298399
15MP0003121_genomic_imprinting2.11067372
16MP0002396_abnormal_hematopoietic_system2.09644164
17MP0010352_gastrointestinal_tract_polyps2.07797786
18MP0001672_abnormal_embryogenesis/_devel1.94549181
19MP0005380_embryogenesis_phenotype1.94549181
20MP0005076_abnormal_cell_differentiation1.91686968
21MP0001697_abnormal_embryo_size1.82718429
22MP0003984_embryonic_growth_retardation1.73348809
23MP0002085_abnormal_embryonic_tissue1.70308343
24MP0002088_abnormal_embryonic_growth/wei1.69346482
25MP0003786_premature_aging1.67470569
26MP0002084_abnormal_developmental_patter1.66534191
27MP0004197_abnormal_fetal_growth/weight/1.59208843
28MP0002086_abnormal_extraembryonic_tissu1.55552435
29MP0004808_abnormal_hematopoietic_stem1.54060344
30MP0003718_maternal_effect1.52914086
31MP0010030_abnormal_orbit_morphology1.52904980
32* MP0002080_prenatal_lethality1.50018447
33MP0003705_abnormal_hypodermis_morpholog1.47781877
34MP0003567_abnormal_fetal_cardiomyocyte1.41798633
35MP0003890_abnormal_embryonic-extraembry1.39464008
36MP0002210_abnormal_sex_determination1.38876245
37MP0003937_abnormal_limbs/digits/tail_de1.34816751
38MP0000569_abnormal_digit_pigmentation1.32786248
39MP0001293_anophthalmia1.31718266
40MP0000313_abnormal_cell_death1.30833521
41MP0000490_abnormal_crypts_of1.30154018
42MP0003787_abnormal_imprinting1.28462348
43MP0008789_abnormal_olfactory_epithelium1.27842380
44MP0002233_abnormal_nose_morphology1.25026861
45MP0009053_abnormal_anal_canal1.24866130
46MP0002019_abnormal_tumor_incidence1.22806531
47MP0001145_abnormal_male_reproductive1.16751800
48MP0001929_abnormal_gametogenesis1.16562730
49MP0009672_abnormal_birth_weight1.08862404
50MP0005499_abnormal_olfactory_system1.07784651
51MP0005394_taste/olfaction_phenotype1.07784651
52MP0000653_abnormal_sex_gland1.06018219
53MP0002234_abnormal_pharynx_morphology1.05770302
54MP0003136_yellow_coat_color1.05298351
55MP0003315_abnormal_perineum_morphology1.04622585
56MP0003941_abnormal_skin_development1.03278356
57MP0009703_decreased_birth_body1.03028284
58MP0006072_abnormal_retinal_apoptosis0.99423313
59MP0000537_abnormal_urethra_morphology0.99308400
60MP0005397_hematopoietic_system_phenotyp0.98153905
61MP0001545_abnormal_hematopoietic_system0.98153905
62MP0001529_abnormal_vocalization0.97940699
63MP0005395_other_phenotype0.95651979
64MP0000733_abnormal_muscle_development0.95221337
65MP0000428_abnormal_craniofacial_morphol0.95062288
66MP0000049_abnormal_middle_ear0.93608962
67MP0001119_abnormal_female_reproductive0.93372654
68MP0001346_abnormal_lacrimal_gland0.93320529
69MP0000703_abnormal_thymus_morphology0.91682580
70MP0000432_abnormal_head_morphology0.91399588
71MP0000647_abnormal_sebaceous_gland0.90061788
72MP0003935_abnormal_craniofacial_develop0.88392409
73MP0002102_abnormal_ear_morphology0.86082163
74MP0002111_abnormal_tail_morphology0.85604842
75MP0001915_intracranial_hemorrhage0.85557812
76MP0002092_abnormal_eye_morphology0.85043979
77MP0004264_abnormal_extraembryonic_tissu0.84911533
78MP0003566_abnormal_cell_adhesion0.83592051
79MP0003115_abnormal_respiratory_system0.83528169
80MP0003755_abnormal_palate_morphology0.83260160
81MP0001286_abnormal_eye_development0.80048408
82MP0005621_abnormal_cell_physiology0.79722019
83MP0002938_white_spotting0.79359456
84MP0009278_abnormal_bone_marrow0.79192599
85MP0003119_abnormal_digestive_system0.79129253
86MP0005023_abnormal_wound_healing0.78140277
87MP0005384_cellular_phenotype0.76400651
88MP0006035_abnormal_mitochondrial_morpho0.76312886
89MP0005391_vision/eye_phenotype0.75744253
90MP0002925_abnormal_cardiovascular_devel0.73900400
91MP0009250_abnormal_appendicular_skeleto0.73844606
92MP0000383_abnormal_hair_follicle0.73459761
93MP0002398_abnormal_bone_marrow0.73177285
94MP0000372_irregular_coat_pigmentation0.71760389
95MP0000358_abnormal_cell_content/0.70786311
96MP0005248_abnormal_Harderian_gland0.70317141
97MP0009697_abnormal_copulation0.69328595
98MP0003385_abnormal_body_wall0.69072355
99MP0002722_abnormal_immune_system0.68528429
100MP0002751_abnormal_autonomic_nervous0.68309435
101MP0000579_abnormal_nail_morphology0.68248661
102MP0001299_abnormal_eye_distance/0.68169070
103MP0002697_abnormal_eye_size0.67697186
104MP0001849_ear_inflammation0.67223007
105MP0006054_spinal_hemorrhage0.66905373
106MP0000762_abnormal_tongue_morphology0.66715143
107MP0009333_abnormal_splenocyte_physiolog0.66538703
108MP0003943_abnormal_hepatobiliary_system0.65835098
109MP0001177_atelectasis0.65545191
110MP0000566_synostosis0.65163468
111MP0002932_abnormal_joint_morphology0.63248093
112MP0003950_abnormal_plasma_membrane0.62876490
113MP0003699_abnormal_female_reproductive0.61797813
114MP0000689_abnormal_spleen_morphology0.61014851
115MP0002109_abnormal_limb_morphology0.60706474
116MP0002177_abnormal_outer_ear0.60476709
117MP0006292_abnormal_olfactory_placode0.60172823
118MP0002160_abnormal_reproductive_system0.60094176
119MP0003698_abnormal_male_reproductive0.59970809
120MP0002114_abnormal_axial_skeleton0.59683198
121MP0005389_reproductive_system_phenotype0.59643940
122MP0003861_abnormal_nervous_system0.59368051
123MP0000427_abnormal_hair_cycle0.58110377
124MP0002081_perinatal_lethality0.57415181
125MP0004133_heterotaxia0.57008963
126MP0002161_abnormal_fertility/fecundity0.56402889
127MP0000631_abnormal_neuroendocrine_gland0.56260002
128MP0000266_abnormal_heart_morphology0.55456393
129MP0010678_abnormal_skin_adnexa0.54155124
130MP0000627_abnormal_mammary_gland0.53535311
131MP0003448_altered_tumor_morphology0.53116120

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.81841372
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.36668006
3Cortical dysplasia (HP:0002539)3.98839592
4Volvulus (HP:0002580)3.84909191
5Abnormality of chromosome stability (HP:0003220)3.65597612
6Impulsivity (HP:0100710)3.47614312
7Birth length less than 3rd percentile (HP:0003561)3.34604748
8Meckel diverticulum (HP:0002245)3.27718679
9Increased nuchal translucency (HP:0010880)3.16167892
10Patellar aplasia (HP:0006443)3.13651272
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10902198
12Short 4th metacarpal (HP:0010044)3.10902198
13Ectopic kidney (HP:0000086)3.10582243
14Abnormality of the ileum (HP:0001549)3.06925283
15Abnormality of the labia minora (HP:0012880)3.06429848
16Abnormality of the preputium (HP:0100587)3.03451242
17Selective tooth agenesis (HP:0001592)2.97151708
18Medulloblastoma (HP:0002885)2.97133610
19Duodenal stenosis (HP:0100867)2.96601292
20Small intestinal stenosis (HP:0012848)2.96601292
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.96426041
22Aplasia/Hypoplasia of the patella (HP:0006498)2.92070981
23Facial hemangioma (HP:0000329)2.83118511
24Breast hypoplasia (HP:0003187)2.82333317
25Nephroblastoma (Wilms tumor) (HP:0002667)2.71785831
26Abnormal lung lobation (HP:0002101)2.69900161
27Myelodysplasia (HP:0002863)2.68030231
28Deviation of the thumb (HP:0009603)2.63730982
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63357196
30Proximal placement of thumb (HP:0009623)2.62936327
31Colon cancer (HP:0003003)2.62235920
32Sloping forehead (HP:0000340)2.57851182
33Embryonal renal neoplasm (HP:0011794)2.55382308
34Rhabdomyosarcoma (HP:0002859)2.51734507
35Absent radius (HP:0003974)2.49983645
36Ependymoma (HP:0002888)2.41153086
37Reticulocytopenia (HP:0001896)2.39172909
38Abnormality of the duodenum (HP:0002246)2.38750443
39Prominent nose (HP:0000448)2.37939620
40Supernumerary spleens (HP:0009799)2.34371080
41Aplasia involving forearm bones (HP:0009822)2.31259807
42Absent forearm bone (HP:0003953)2.31259807
43Abnormality of the carotid arteries (HP:0005344)2.28213139
44Abnormal umbilical cord blood vessels (HP:0011403)2.26873375
45Single umbilical artery (HP:0001195)2.26873375
46Abnormality of the fetal cardiovascular system (HP:0010948)2.26873375
47Cafe-au-lait spot (HP:0000957)2.26377035
48Hypoplastic pelvis (HP:0008839)2.25830482
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.25744421
50Long eyelashes (HP:0000527)2.25443931
51Embryonal neoplasm (HP:0002898)2.25416865
52Atresia of the external auditory canal (HP:0000413)2.24029587
53High pitched voice (HP:0001620)2.22149376
54Abnormal number of incisors (HP:0011064)2.21494369
55Carpal bone hypoplasia (HP:0001498)2.18807354
56Abnormality of the fingertips (HP:0001211)2.17776403
57Degeneration of anterior horn cells (HP:0002398)2.16987832
58Abnormality of the anterior horn cell (HP:0006802)2.16987832
59Missing ribs (HP:0000921)2.14012961
60Deep philtrum (HP:0002002)2.09842387
61Short thumb (HP:0009778)2.09612497
62Abnormality of the 4th metacarpal (HP:0010012)2.08829010
63Small hand (HP:0200055)2.07428124
64Septo-optic dysplasia (HP:0100842)2.05009680
6511 pairs of ribs (HP:0000878)2.00595151
66Acute myeloid leukemia (HP:0004808)1.99901695
67Neoplasm of the oral cavity (HP:0100649)1.98671063
68Duplication of thumb phalanx (HP:0009942)1.97847519
69Bone marrow hypocellularity (HP:0005528)1.96312843
70Sandal gap (HP:0001852)1.94443372
71Agnosia (HP:0010524)1.93275483
72Absent thumb (HP:0009777)1.92960397
73Intestinal atresia (HP:0011100)1.92034698
74Tracheoesophageal fistula (HP:0002575)1.91990021
75Abnormality of the septum pellucidum (HP:0007375)1.91425478
76Squamous cell carcinoma (HP:0002860)1.91256003
77Clubbing of toes (HP:0100760)1.90732122
78Neoplasm of the pancreas (HP:0002894)1.89383711
79Neoplasm of striated muscle (HP:0009728)1.89378362
80Oligodactyly (HP:0012165)1.89194798
81Abnormality of chromosome segregation (HP:0002916)1.89050053
82Glioma (HP:0009733)1.88807161
83Astrocytoma (HP:0009592)1.88619800
84Abnormality of the astrocytes (HP:0100707)1.88619800
85Aplasia/Hypoplasia of the earlobes (HP:0009906)1.87201758
86Bifid tongue (HP:0010297)1.86493403
87Absent septum pellucidum (HP:0001331)1.86047720
88Horseshoe kidney (HP:0000085)1.84847822
89Blepharitis (HP:0000498)1.84269666
90Microtia (HP:0008551)1.83991594
91Pancreatic islet-cell hyperplasia (HP:0004510)1.83080494
92Oral leukoplakia (HP:0002745)1.79914046
93Gastrointestinal carcinoma (HP:0002672)1.79110422
94Malignant gastrointestinal tract tumors (HP:0006749)1.79110422
95Triphalangeal thumb (HP:0001199)1.78683050
96Duplicated collecting system (HP:0000081)1.78480755
97Basal cell carcinoma (HP:0002671)1.78221304
98Abnormality of the calcaneus (HP:0008364)1.75975868
99Ovarian neoplasm (HP:0100615)1.75739007
100Skull defect (HP:0001362)1.75620524
101Capillary hemangiomas (HP:0005306)1.75568204
102Biliary tract neoplasm (HP:0100574)1.75518547
103Shawl scrotum (HP:0000049)1.74507675
104Papillary thyroid carcinoma (HP:0002895)1.73997140
105Long clavicles (HP:0000890)1.73318434
106Overlapping toe (HP:0001845)1.72941108
107Short middle phalanx of the 5th finger (HP:0004220)1.72743928
108Abnormality of the renal collecting system (HP:0004742)1.72181027
109Abnormality of cochlea (HP:0000375)1.71557594
110Arteriovenous malformation (HP:0100026)1.71268833
111Ankle contracture (HP:0006466)1.70921576
112Premature graying of hair (HP:0002216)1.70876133
113Abnormality of the umbilical cord (HP:0010881)1.70549627
114Syringomyelia (HP:0003396)1.70164634
115Spinal cord lesions (HP:0100561)1.70164634
116Oligodactyly (hands) (HP:0001180)1.69812183
117Neoplasm of the colon (HP:0100273)1.69636692
118Dandy-Walker malformation (HP:0001305)1.69141652
119Supernumerary ribs (HP:0005815)1.68841525
120Choanal atresia (HP:0000453)1.68071142
121Wrist flexion contracture (HP:0001239)1.66655791
122Broad thumb (HP:0011304)1.66431622
123Abnormal auditory evoked potentials (HP:0006958)1.65950189
124Abnormality of abdominal situs (HP:0011620)1.60213227
125Abdominal situs inversus (HP:0003363)1.60213227
126Holoprosencephaly (HP:0001360)1.59482340
127Gastrointestinal atresia (HP:0002589)1.59198478
128Preaxial hand polydactyly (HP:0001177)1.55970985
129Hypoplasia of the pons (HP:0012110)1.53953492
130Abnormality of the pons (HP:0007361)1.53770207
131Hypoplastic labia majora (HP:0000059)1.53706975
132Esophageal atresia (HP:0002032)1.53062547
133High anterior hairline (HP:0009890)1.52555043
134Multiple enchondromatosis (HP:0005701)1.51152922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.94569494
2BUB14.22297981
3WEE13.88796248
4NEK23.82237863
5CDK123.36691557
6TTK3.09688484
7BRSK22.77708213
8PLK42.62314663
9EIF2AK12.58027723
10NEK12.55033076
11PLK12.39104138
12SRPK12.24425784
13AURKB2.12446615
14PLK32.10643396
15MKNK11.98002495
16CHEK21.95886066
17ATR1.79850033
18BRSK11.73171794
19LATS11.70917719
20STK101.69810241
21STK41.61497874
22MKNK21.57027943
23STK31.56354485
24ACVR1B1.55475302
25CHEK11.54334070
26MST41.49945990
27CDK71.48728224
28CDK41.45550059
29MAP3K81.42925825
30TNIK1.39629309
31BRD41.38751266
32TLK11.38577486
33TAF11.32691443
34TSSK61.32673976
35RPS6KA41.29763548
36MELK1.28910547
37TRIM281.27047350
38ATM1.24352224
39ZAK1.23633946
40CDK61.22231037
41CCNB11.18123319
42VRK11.17524723
43EEF2K1.16223490
44BMPR1B1.14709205
45WNK31.13248628
46VRK21.13097515
47AURKA1.13039104
48PASK1.13033961
49RPS6KB21.11934759
50STK38L1.04949857
51DYRK31.02056089
52CDK21.00486273
53CDK10.90368128
54LATS20.88520084
55TESK20.82356853
56PNCK0.81698935
57NUAK10.79495514
58EIF2AK30.76111876
59EPHA20.76040961
60PIM10.72121057
61ALK0.71827980
62MAP3K100.71363660
63EIF2AK20.69887677
64STK160.68041885
65PAK40.67864842
66MTOR0.66938113
67PKN20.64786507
68TGFBR10.63502967
69BRAF0.62205018
70SCYL20.62022418
71CDK90.61026350
72PBK0.60106867
73CLK10.58741804
74TTN0.55764010
75MARK30.53933048
76CDK80.51558651
77BCR0.50468313
78ERBB40.48298991
79PAK10.48282677
80CSNK2A10.47965985
81STK390.47432870
82PRKDC0.47216475
83CSNK2A20.47111035
84MET0.46696239
85NME10.45431579
86NEK90.42927898
87RPS6KA50.42880958
88MAPK140.42807614
89NME20.40267769
90CSNK1D0.39493945
91DMPK0.38812748
92CSNK1E0.37629815
93MAP3K40.37609654
94PRKCI0.35227531
95CAMK1G0.34109843
96LRRK20.33988232
97CHUK0.33209626
98CAMK1D0.31637768
99PDK20.30941478
100AKT10.29470248
101GSK3B0.29305883
102PAK20.26356393
103* MAPK10.26110813
104CSNK1G10.26106375
105FGFR10.25599572
106CDK180.24743218
107AKT20.24413926
108AKT30.23511663
109FLT30.22629956
110CDK150.22068591
111PKN10.21129347
112PDK40.20742728
113PDK30.20742728
114UHMK10.20237937
115ERBB30.20223543
116CDK11A0.20022531
117NEK60.19709845
118YES10.17943048
119PLK20.17720745
120NLK0.17390349
121MAPK130.16309994
122ERBB20.16140172
123WNK40.15945394
124MAPK100.15607068
125MAP3K60.15044607
126MAP4K10.13759173
127TRPM70.13146443
128CDK30.12660483

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25538771
2Mismatch repair_Homo sapiens_hsa034303.84102416
3Cell cycle_Homo sapiens_hsa041103.71036820
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42630382
5Homologous recombination_Homo sapiens_hsa034403.32958161
6RNA transport_Homo sapiens_hsa030133.32828473
7Spliceosome_Homo sapiens_hsa030403.11867650
8Fanconi anemia pathway_Homo sapiens_hsa034602.90768164
9Base excision repair_Homo sapiens_hsa034102.87319991
10Nucleotide excision repair_Homo sapiens_hsa034202.60223361
11Non-homologous end-joining_Homo sapiens_hsa034502.46293841
12RNA polymerase_Homo sapiens_hsa030202.42823744
13One carbon pool by folate_Homo sapiens_hsa006702.23985536
14Basal transcription factors_Homo sapiens_hsa030222.18397421
15mRNA surveillance pathway_Homo sapiens_hsa030152.17502327
16p53 signaling pathway_Homo sapiens_hsa041152.13913748
17RNA degradation_Homo sapiens_hsa030182.13783922
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90481029
19Systemic lupus erythematosus_Homo sapiens_hsa053221.86259561
20Protein export_Homo sapiens_hsa030601.82139392
21Pyrimidine metabolism_Homo sapiens_hsa002401.78785861
22Oocyte meiosis_Homo sapiens_hsa041141.63912606
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.63910017
24Ribosome_Homo sapiens_hsa030101.60829336
25Proteasome_Homo sapiens_hsa030501.59228971
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46321815
27Steroid biosynthesis_Homo sapiens_hsa001001.43283800
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39477536
29MicroRNAs in cancer_Homo sapiens_hsa052061.38401857
30Viral carcinogenesis_Homo sapiens_hsa052031.36714798
31Epstein-Barr virus infection_Homo sapiens_hsa051691.26702840
32Herpes simplex infection_Homo sapiens_hsa051681.17852750
33Vitamin B6 metabolism_Homo sapiens_hsa007501.12648138
34Pyruvate metabolism_Homo sapiens_hsa006201.11931503
35Small cell lung cancer_Homo sapiens_hsa052221.09150832
36HTLV-I infection_Homo sapiens_hsa051661.07845541
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04929257
38Propanoate metabolism_Homo sapiens_hsa006401.03224641
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94285988
40Antigen processing and presentation_Homo sapiens_hsa046120.94121992
41Purine metabolism_Homo sapiens_hsa002300.93076911
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91014754
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85991339
44TGF-beta signaling pathway_Homo sapiens_hsa043500.85950828
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85167648
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81524024
47Thyroid cancer_Homo sapiens_hsa052160.81398875
48Adherens junction_Homo sapiens_hsa045200.81259757
49Hippo signaling pathway_Homo sapiens_hsa043900.80239134
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79441530
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78628966
52Huntingtons disease_Homo sapiens_hsa050160.75608219
53Colorectal cancer_Homo sapiens_hsa052100.75182008
54Alcoholism_Homo sapiens_hsa050340.74916007
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73112701
56Chronic myeloid leukemia_Homo sapiens_hsa052200.72563695
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71111189
58Folate biosynthesis_Homo sapiens_hsa007900.70368885
59Basal cell carcinoma_Homo sapiens_hsa052170.70257501
60Lysine degradation_Homo sapiens_hsa003100.65824968
61Parkinsons disease_Homo sapiens_hsa050120.65167404
62Selenocompound metabolism_Homo sapiens_hsa004500.64614644
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63608051
64Prostate cancer_Homo sapiens_hsa052150.63545470
65Hepatitis B_Homo sapiens_hsa051610.62420559
66Viral myocarditis_Homo sapiens_hsa054160.58910080
67Pancreatic cancer_Homo sapiens_hsa052120.58473649
68Notch signaling pathway_Homo sapiens_hsa043300.56845752
69Apoptosis_Homo sapiens_hsa042100.56138809
70mTOR signaling pathway_Homo sapiens_hsa041500.53314754
71FoxO signaling pathway_Homo sapiens_hsa040680.52801833
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52364568
73Pathways in cancer_Homo sapiens_hsa052000.52258588
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.52134462
75Influenza A_Homo sapiens_hsa051640.51126955
76Hedgehog signaling pathway_Homo sapiens_hsa043400.50188830
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50046531
78Glutathione metabolism_Homo sapiens_hsa004800.49811539
79Oxidative phosphorylation_Homo sapiens_hsa001900.49765394
80Measles_Homo sapiens_hsa051620.48075777
81Fatty acid elongation_Homo sapiens_hsa000620.47720805
82Primary immunodeficiency_Homo sapiens_hsa053400.47249486
83Non-small cell lung cancer_Homo sapiens_hsa052230.46850276
84Carbon metabolism_Homo sapiens_hsa012000.46175846
85Proteoglycans in cancer_Homo sapiens_hsa052050.45765222
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45542802
87Pentose phosphate pathway_Homo sapiens_hsa000300.44625386
88Bladder cancer_Homo sapiens_hsa052190.43483043
89Shigellosis_Homo sapiens_hsa051310.42166509
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41499530
91Legionellosis_Homo sapiens_hsa051340.40991190
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.40587610
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39253688
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36548751
95Endometrial cancer_Homo sapiens_hsa052130.36253520
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35944941
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34987074
98Melanoma_Homo sapiens_hsa052180.34583006
99HIF-1 signaling pathway_Homo sapiens_hsa040660.34549052
100Wnt signaling pathway_Homo sapiens_hsa043100.33995519
101Biosynthesis of amino acids_Homo sapiens_hsa012300.33160266
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32870775
103Tight junction_Homo sapiens_hsa045300.32234833
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.32217746
105Hematopoietic cell lineage_Homo sapiens_hsa046400.32082498
106N-Glycan biosynthesis_Homo sapiens_hsa005100.31195497
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.31084276
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30539418
109Metabolic pathways_Homo sapiens_hsa011000.29956944
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29845598
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28405094
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27137879
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.27103093
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24814169
115Vitamin digestion and absorption_Homo sapiens_hsa049770.24326425
116Focal adhesion_Homo sapiens_hsa045100.23415346
117Toxoplasmosis_Homo sapiens_hsa051450.22215515
118Fatty acid metabolism_Homo sapiens_hsa012120.21791036
119B cell receptor signaling pathway_Homo sapiens_hsa046620.21612882
120Renin-angiotensin system_Homo sapiens_hsa046140.20633990
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.20601286
122Renal cell carcinoma_Homo sapiens_hsa052110.20533451
123ECM-receptor interaction_Homo sapiens_hsa045120.20412875
124Acute myeloid leukemia_Homo sapiens_hsa052210.20240108
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19843380
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19716287
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19344875
128Alzheimers disease_Homo sapiens_hsa050100.19010590
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17960194
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16779433
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.16261503
132Leishmaniasis_Homo sapiens_hsa051400.15946680
133Phototransduction_Homo sapiens_hsa047440.13607943
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11886107
135Butanoate metabolism_Homo sapiens_hsa006500.11697485
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10896867
137Olfactory transduction_Homo sapiens_hsa047400.10259794
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09815342
139Caffeine metabolism_Homo sapiens_hsa002320.05814204
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03635472

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