CENPF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.93113216
2protein localization to kinetochore (GO:0034501)5.69029562
3* kinetochore organization (GO:0051383)5.56493642
4sister chromatid segregation (GO:0000819)5.47579292
5mitotic sister chromatid segregation (GO:0000070)5.46367459
6nuclear pore complex assembly (GO:0051292)5.43045395
7mitotic metaphase plate congression (GO:0007080)5.36865664
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.36782662
9nuclear pore organization (GO:0006999)5.31641366
10attachment of spindle microtubules to kinetochore (GO:0008608)5.12933933
11protein localization to chromosome, centromeric region (GO:0071459)5.12628970
12mitotic sister chromatid cohesion (GO:0007064)4.96085916
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.82007257
14meiotic chromosome segregation (GO:0045132)4.81762457
15chromatin remodeling at centromere (GO:0031055)4.73616780
16regulation of spindle organization (GO:0090224)4.73327220
17CENP-A containing nucleosome assembly (GO:0034080)4.68389082
18regulation of mitotic spindle organization (GO:0060236)4.62150508
19* metaphase plate congression (GO:0051310)4.55299612
20DNA unwinding involved in DNA replication (GO:0006268)4.53083396
21* kinetochore assembly (GO:0051382)4.40641371
22DNA replication-independent nucleosome assembly (GO:0006336)4.36517960
23DNA replication-independent nucleosome organization (GO:0034724)4.36517960
24positive regulation of mitotic sister chromatid separation (GO:1901970)4.28880246
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.28880246
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.28880246
27mitotic nuclear envelope disassembly (GO:0007077)4.25770177
28* establishment of chromosome localization (GO:0051303)4.20523283
29histone exchange (GO:0043486)4.19758805
30pore complex assembly (GO:0046931)4.10784451
31positive regulation of chromosome segregation (GO:0051984)4.10120530
32DNA replication-dependent nucleosome assembly (GO:0006335)4.08614649
33DNA replication-dependent nucleosome organization (GO:0034723)4.08614649
34regulation of sister chromatid cohesion (GO:0007063)4.04277880
35chromosome condensation (GO:0030261)4.02351528
36protein localization to chromosome (GO:0034502)4.01770342
37* spindle checkpoint (GO:0031577)3.99016104
38nuclear envelope disassembly (GO:0051081)3.98786263
39membrane disassembly (GO:0030397)3.98786263
40* chromosome segregation (GO:0007059)3.97283569
41regulation of centriole replication (GO:0046599)3.96167411
42* regulation of chromosome segregation (GO:0051983)3.95535401
43DNA topological change (GO:0006265)3.87473071
44microtubule depolymerization (GO:0007019)3.84318482
45chromatin assembly or disassembly (GO:0006333)3.83377656
46* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.83051582
47* spindle assembly checkpoint (GO:0071173)3.81052051
48* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.76864512
49regulation of histone H3-K9 methylation (GO:0051570)3.74152339
50double-strand break repair via nonhomologous end joining (GO:0006303)3.74090670
51non-recombinational repair (GO:0000726)3.74090670
52regulation of centrosome cycle (GO:0046605)3.73423239
53* negative regulation of chromosome segregation (GO:0051985)3.68888225
54mitotic cytokinesis (GO:0000281)3.67777648
55DNA packaging (GO:0006323)3.67745409
56* negative regulation of mitotic sister chromatid separation (GO:2000816)3.64645493
57* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.64645493
58* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.64645493
59* negative regulation of sister chromatid segregation (GO:0033046)3.64645493
60* regulation of mitotic sister chromatid separation (GO:0010965)3.64383172
61* regulation of mitotic sister chromatid segregation (GO:0033047)3.64383172
62* regulation of sister chromatid segregation (GO:0033045)3.64383172
63* mitotic spindle checkpoint (GO:0071174)3.59973316
64* mitotic spindle assembly checkpoint (GO:0007094)3.58694534
65* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.57141314
66replication fork processing (GO:0031297)3.54761824
67ATP-dependent chromatin remodeling (GO:0043044)3.52860500
68negative regulation of histone methylation (GO:0031061)3.51252441
69DNA replication initiation (GO:0006270)3.50768296
70protein K6-linked ubiquitination (GO:0085020)3.50766110
71mitotic recombination (GO:0006312)3.49638513
72DNA geometric change (GO:0032392)3.49217029
73ventricular cardiac muscle cell development (GO:0055015)3.49067490
74DNA duplex unwinding (GO:0032508)3.48183755
75DNA replication checkpoint (GO:0000076)3.47081581
76mitotic spindle organization (GO:0007052)3.46561360
77microtubule polymerization or depolymerization (GO:0031109)3.42599843
78establishment of integrated proviral latency (GO:0075713)3.41026259
79DNA strand elongation involved in DNA replication (GO:0006271)3.39522599
80DNA conformation change (GO:0071103)3.38070255
81pre-miRNA processing (GO:0031054)3.37362091
82regulation of DNA endoreduplication (GO:0032875)3.35512029
83heterochromatin organization (GO:0070828)3.34295677
84centriole replication (GO:0007099)3.32663145
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27547863
86regulation of RNA export from nucleus (GO:0046831)3.24856877
87DNA strand elongation (GO:0022616)3.22445732
88mitotic G2 DNA damage checkpoint (GO:0007095)3.22188431
89sister chromatid cohesion (GO:0007062)3.21993056
90spindle assembly involved in mitosis (GO:0090307)3.20258411
91histone-serine phosphorylation (GO:0035404)3.19319610
92chromatin assembly (GO:0031497)3.18992388
93telomere maintenance via recombination (GO:0000722)3.18056593
94* negative regulation of mitosis (GO:0045839)3.17248764
95telomere maintenance via semi-conservative replication (GO:0032201)3.15631409
96regulation of centrosome duplication (GO:0010824)3.14769236
97V(D)J recombination (GO:0033151)3.13408842
98DNA double-strand break processing (GO:0000729)3.12223210
99centrosome organization (GO:0051297)3.11229771
100* mitotic nuclear division (GO:0007067)3.10588775
101negative regulation of DNA-dependent DNA replication (GO:2000104)3.07972283
102nuclear envelope organization (GO:0006998)3.07305439
103resolution of meiotic recombination intermediates (GO:0000712)3.06505381
104nucleotide-excision repair, DNA gap filling (GO:0006297)3.06073798
105DNA ligation (GO:0006266)3.05566414
106paraxial mesoderm development (GO:0048339)3.04231881
107regulation of telomere maintenance via telomerase (GO:0032210)3.03257449
108* chromosome organization (GO:0051276)3.02521488
109regulation of double-strand break repair (GO:2000779)3.01658550
110dosage compensation (GO:0007549)2.99630573
111regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98150052
112establishment of mitotic spindle localization (GO:0040001)2.97027636
113DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.94882201
114* mitotic cell cycle (GO:0000278)2.91617235
115regulation of helicase activity (GO:0051095)2.88185435
116translesion synthesis (GO:0019985)2.87329012
117negative regulation of DNA repair (GO:0045738)2.86448361
118monoubiquitinated protein deubiquitination (GO:0035520)2.85691059
119mitotic G2/M transition checkpoint (GO:0044818)2.85512441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human8.28778164
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.28911023
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.78858772
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.31766088
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.04304195
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.95166090
7AR_21909140_ChIP-Seq_LNCAP_Human2.93494003
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.63631309
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62396078
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.61592249
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.47483700
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41668956
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.37384818
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30853181
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25730490
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21290034
17* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07925145
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.02647754
19E2F7_22180533_ChIP-Seq_HELA_Human10.8431001
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99810967
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97664604
22* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96513964
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.93263899
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90215731
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82842860
26XRN2_22483619_ChIP-Seq_HELA_Human1.81845068
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78141396
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68927779
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64344582
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61517824
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56219061
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53467348
33VDR_23849224_ChIP-Seq_CD4+_Human1.52810714
34CIITA_25753668_ChIP-Seq_RAJI_Human1.51034031
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50895168
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50839429
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50600529
38ELK1_19687146_ChIP-ChIP_HELA_Human1.47213780
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.47121541
40* TTF2_22483619_ChIP-Seq_HELA_Human1.46402400
41FOXP3_21729870_ChIP-Seq_TREG_Human1.44901293
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33838856
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31965035
44* KDM5A_27292631_Chip-Seq_BREAST_Human1.29894929
45DCP1A_22483619_ChIP-Seq_HELA_Human1.27991564
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27648765
47MYC_22102868_ChIP-Seq_BL_Human1.27533820
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.27471702
49* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20662481
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20186726
51FUS_26573619_Chip-Seq_HEK293_Human1.19462739
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18014066
53* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17359685
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16923062
55* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16777020
56SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15955930
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14422573
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11311288
59GABP_19822575_ChIP-Seq_HepG2_Human1.11265724
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10890515
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.10837545
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09267988
63* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08787369
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07957126
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07587903
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07587903
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07587903
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06572714
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02463275
70MYC_18940864_ChIP-ChIP_HL60_Human0.98110529
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97962733
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97760149
73SOX2_16153702_ChIP-ChIP_HESCs_Human0.97404462
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93801080
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92967780
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92631519
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91342284
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90577805
79TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89940543
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89595584
81PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89583035
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88809214
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88750560
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.88614915
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87733362
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84938951
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84411333
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84162072
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83660340
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83255207
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82191024
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.82054850
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81056169
94TFEB_21752829_ChIP-Seq_HELA_Human0.79752906
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78711075
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.77867247
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.77816168
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77719364
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.77199409
100EWS_26573619_Chip-Seq_HEK293_Human0.77066829
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76693224
102* SOX9_26525672_Chip-Seq_HEART_Mouse0.76269120
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75506825
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75405996
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74846952
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73160771
107CHD1_26751641_Chip-Seq_LNCaP_Human0.72915098
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71421241
109NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.69049615
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66552196
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.66343851
112* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64727283
113TAF15_26573619_Chip-Seq_HEK293_Human0.60891480
114IRF1_19129219_ChIP-ChIP_H3396_Human0.59367409
115SRF_21415370_ChIP-Seq_HL-1_Mouse0.59049715
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.58449409
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.56892737
118GATA1_22025678_ChIP-Seq_K562_Human0.55776545
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.54976411
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.54903668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.64842854
2MP0003693_abnormal_embryo_hatching4.57835494
3MP0003111_abnormal_nucleus_morphology4.36578686
4MP0003077_abnormal_cell_cycle3.91351352
5MP0004957_abnormal_blastocyst_morpholog3.67772027
6MP0008057_abnormal_DNA_replication3.58320290
7MP0008877_abnormal_DNA_methylation3.20893703
8MP0003123_paternal_imprinting2.81519738
9MP0008058_abnormal_DNA_repair2.75854505
10MP0008007_abnormal_cellular_replicative2.60110656
11MP0008932_abnormal_embryonic_tissue2.43534169
12MP0003121_genomic_imprinting2.38597893
13MP0010307_abnormal_tumor_latency2.30155663
14MP0001730_embryonic_growth_arrest2.23998614
15MP0000350_abnormal_cell_proliferation2.16321407
16MP0009697_abnormal_copulation2.12415281
17MP0003136_yellow_coat_color2.06830518
18MP0010352_gastrointestinal_tract_polyps2.06779756
19MP0010030_abnormal_orbit_morphology1.95403638
20MP0001672_abnormal_embryogenesis/_devel1.91407243
21MP0005380_embryogenesis_phenotype1.91407243
22MP0005076_abnormal_cell_differentiation1.87829175
23MP0003890_abnormal_embryonic-extraembry1.84099080
24MP0001697_abnormal_embryo_size1.83442717
25MP0002085_abnormal_embryonic_tissue1.80914194
26MP0002084_abnormal_developmental_patter1.80122420
27MP0003787_abnormal_imprinting1.74955872
28MP0003984_embryonic_growth_retardation1.69970537
29MP0004197_abnormal_fetal_growth/weight/1.67332051
30MP0002088_abnormal_embryonic_growth/wei1.66367091
31MP0003786_premature_aging1.62045848
32MP0002210_abnormal_sex_determination1.59331062
33MP0003937_abnormal_limbs/digits/tail_de1.58811289
34MP0002396_abnormal_hematopoietic_system1.56008012
35MP0002086_abnormal_extraembryonic_tissu1.55872354
36MP0005171_absent_coat_pigmentation1.54683226
37MP0001293_anophthalmia1.48965710
38MP0003567_abnormal_fetal_cardiomyocyte1.48659743
39MP0000569_abnormal_digit_pigmentation1.46202533
40MP0002080_prenatal_lethality1.45256662
41MP0000372_irregular_coat_pigmentation1.44246214
42MP0003705_abnormal_hypodermis_morpholog1.42580453
43MP0001929_abnormal_gametogenesis1.34793397
44MP0002009_preneoplasia1.34050506
45MP0009053_abnormal_anal_canal1.33641109
46MP0000537_abnormal_urethra_morphology1.32815092
47MP0001145_abnormal_male_reproductive1.32630286
48MP0004808_abnormal_hematopoietic_stem1.30849600
49MP0003941_abnormal_skin_development1.28137392
50MP0003315_abnormal_perineum_morphology1.23522396
51MP0000313_abnormal_cell_death1.22603360
52MP0000653_abnormal_sex_gland1.20705157
53MP0000490_abnormal_crypts_of1.16208507
54MP0009672_abnormal_birth_weight1.12735775
55MP0003718_maternal_effect1.12544975
56MP0003119_abnormal_digestive_system1.09852669
57MP0009703_decreased_birth_body1.09498836
58MP0002019_abnormal_tumor_incidence1.09050887
59MP0005408_hypopigmentation1.09037599
60MP0002234_abnormal_pharynx_morphology1.06144920
61MP0003935_abnormal_craniofacial_develop1.05436951
62MP0005248_abnormal_Harderian_gland1.04615666
63MP0000432_abnormal_head_morphology1.02404048
64MP0001119_abnormal_female_reproductive1.00279676
65MP0001346_abnormal_lacrimal_gland0.99143765
66MP0005391_vision/eye_phenotype0.97457712
67MP0003755_abnormal_palate_morphology0.96296330
68MP0001299_abnormal_eye_distance/0.96077315
69MP0001286_abnormal_eye_development0.95731282
70MP0008789_abnormal_olfactory_epithelium0.95135223
71MP0006292_abnormal_olfactory_placode0.94729680
72MP0003115_abnormal_respiratory_system0.94126052
73MP0002111_abnormal_tail_morphology0.93033365
74MP0006072_abnormal_retinal_apoptosis0.92903720
75MP0002938_white_spotting0.91602837
76MP0002092_abnormal_eye_morphology0.90987014
77MP0000733_abnormal_muscle_development0.89129090
78MP0002697_abnormal_eye_size0.88985569
79MP0000428_abnormal_craniofacial_morphol0.88758630
80MP0002095_abnormal_skin_pigmentation0.88129801
81MP0002653_abnormal_ependyma_morphology0.88060249
82MP0001915_intracranial_hemorrhage0.86866744
83MP0003385_abnormal_body_wall0.85213438
84MP0002877_abnormal_melanocyte_morpholog0.85096778
85MP0000647_abnormal_sebaceous_gland0.83060030
86MP0003861_abnormal_nervous_system0.82737894
87MP0002925_abnormal_cardiovascular_devel0.80599790
88MP0003698_abnormal_male_reproductive0.80465202
89MP0001529_abnormal_vocalization0.80170458
90MP0002932_abnormal_joint_morphology0.80051837
91MP0006054_spinal_hemorrhage0.79828731
92MP0000566_synostosis0.78462900
93MP0000383_abnormal_hair_follicle0.78405681
94MP0002751_abnormal_autonomic_nervous0.78305670
95MP0008995_early_reproductive_senescence0.77706983
96MP0000703_abnormal_thymus_morphology0.77612182
97MP0000049_abnormal_middle_ear0.77590793
98MP0004264_abnormal_extraembryonic_tissu0.77286787
99MP0001849_ear_inflammation0.77143040
100MP0000579_abnormal_nail_morphology0.74756739
101MP0000358_abnormal_cell_content/0.73186603
102MP0000778_abnormal_nervous_system0.72921374
103MP0005395_other_phenotype0.72503381
104MP0005394_taste/olfaction_phenotype0.71880240
105MP0005499_abnormal_olfactory_system0.71880240
106MP0009278_abnormal_bone_marrow0.71593085
107MP0002249_abnormal_larynx_morphology0.70903385
108MP0005397_hematopoietic_system_phenotyp0.70492414
109MP0001545_abnormal_hematopoietic_system0.70492414
110MP0002102_abnormal_ear_morphology0.70414541
111MP0002116_abnormal_craniofacial_bone0.69808143
112MP0002114_abnormal_axial_skeleton0.69490923
113MP0002233_abnormal_nose_morphology0.68214920
114MP0002081_perinatal_lethality0.68154327
115MP0002177_abnormal_outer_ear0.67594433
116MP0000427_abnormal_hair_cycle0.67111347
117MP0003699_abnormal_female_reproductive0.66309723
118MP0002160_abnormal_reproductive_system0.65902115
119MP0003938_abnormal_ear_development0.65506672
120MP0003942_abnormal_urinary_system0.65328944
121MP0002161_abnormal_fertility/fecundity0.65146039
122MP0005253_abnormal_eye_physiology0.64930918
123MP0005174_abnormal_tail_pigmentation0.64241871
124MP0003566_abnormal_cell_adhesion0.63802924
125MP0010678_abnormal_skin_adnexa0.63318775
126MP0005384_cellular_phenotype0.63172535
127MP0009250_abnormal_appendicular_skeleto0.63153015
128MP0002282_abnormal_trachea_morphology0.62997405
129MP0005187_abnormal_penis_morphology0.62695848
130MP0005621_abnormal_cell_physiology0.62427074
131MP0005023_abnormal_wound_healing0.62337775

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.87567275
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38863984
3Volvulus (HP:0002580)4.15062350
4Abnormality of chromosome stability (HP:0003220)3.58857078
5Medulloblastoma (HP:0002885)3.41741703
6Increased nuchal translucency (HP:0010880)3.29056160
7Impulsivity (HP:0100710)3.25067115
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.18612739
9Short 4th metacarpal (HP:0010044)3.18612739
10Meckel diverticulum (HP:0002245)3.14110043
11Colon cancer (HP:0003003)3.10232798
12Ectopic kidney (HP:0000086)3.09383529
13Abnormality of the labia minora (HP:0012880)3.01028588
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.98762250
15Abnormality of the ileum (HP:0001549)2.96390935
16Duodenal stenosis (HP:0100867)2.96128649
17Small intestinal stenosis (HP:0012848)2.96128649
18Ependymoma (HP:0002888)2.91781735
19Abnormality of the preputium (HP:0100587)2.90128139
20Patellar aplasia (HP:0006443)2.85646374
21Nephroblastoma (Wilms tumor) (HP:0002667)2.85202711
22Abnormal lung lobation (HP:0002101)2.75316407
23Selective tooth agenesis (HP:0001592)2.74315768
24Rhabdomyosarcoma (HP:0002859)2.74039497
25Absent radius (HP:0003974)2.68350355
26Facial hemangioma (HP:0000329)2.66650429
27Embryonal renal neoplasm (HP:0011794)2.66555287
28Aplasia/Hypoplasia of the patella (HP:0006498)2.63731726
29Proximal placement of thumb (HP:0009623)2.56726669
30Deviation of the thumb (HP:0009603)2.55558264
31Myelodysplasia (HP:0002863)2.54185043
32Reticulocytopenia (HP:0001896)2.53839091
33Abnormality of the duodenum (HP:0002246)2.53173474
34Sloping forehead (HP:0000340)2.52897187
35Absent forearm bone (HP:0003953)2.50201026
36Aplasia involving forearm bones (HP:0009822)2.50201026
37Birth length less than 3rd percentile (HP:0003561)2.49194804
38Neoplasm of the oral cavity (HP:0100649)2.46796815
39Supernumerary spleens (HP:0009799)2.46221465
40Long clavicles (HP:0000890)2.45187006
41Astrocytoma (HP:0009592)2.42494155
42Abnormality of the astrocytes (HP:0100707)2.42494155
43Abnormal number of incisors (HP:0011064)2.40840033
44Abnormality of the fingertips (HP:0001211)2.38742281
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.35377941
46Abnormality of the carotid arteries (HP:0005344)2.34170006
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30626627
48Oligodactyly (HP:0012165)2.26572048
49Long eyelashes (HP:0000527)2.25960343
50Neoplasm of striated muscle (HP:0009728)2.25217148
51Cafe-au-lait spot (HP:0000957)2.24605800
52Glioma (HP:0009733)2.22979921
53Abnormality of the 4th metacarpal (HP:0010012)2.21838637
54Oligodactyly (hands) (HP:0001180)2.20328893
55Short thumb (HP:0009778)2.19014034
56Atresia of the external auditory canal (HP:0000413)2.16831950
57Embryonal neoplasm (HP:0002898)2.13613448
58Breast hypoplasia (HP:0003187)2.13548900
59Intestinal atresia (HP:0011100)2.13432936
60Prominent nose (HP:0000448)2.11725168
61Abnormality of chromosome segregation (HP:0002916)2.11525903
62Supernumerary ribs (HP:0005815)2.07673824
63Papillary thyroid carcinoma (HP:0002895)2.07436772
64Biliary tract neoplasm (HP:0100574)2.06693421
65Deep philtrum (HP:0002002)2.05327482
66Abnormality of abdominal situs (HP:0011620)2.04561693
67Abdominal situs inversus (HP:0003363)2.04561693
68Truncal obesity (HP:0001956)2.04012563
69Skull defect (HP:0001362)2.03326428
70Absent thumb (HP:0009777)2.02537454
71High pitched voice (HP:0001620)2.02242241
72Sandal gap (HP:0001852)2.02206654
7311 pairs of ribs (HP:0000878)2.01802937
74Supernumerary bones of the axial skeleton (HP:0009144)2.01380840
75Duplicated collecting system (HP:0000081)2.01326175
76Overlapping toe (HP:0001845)1.99578287
77Duplication of thumb phalanx (HP:0009942)1.99106546
78Agnosia (HP:0010524)1.97577290
79Gastrointestinal carcinoma (HP:0002672)1.93979709
80Malignant gastrointestinal tract tumors (HP:0006749)1.93979709
81Shawl scrotum (HP:0000049)1.93729631
82Renal duplication (HP:0000075)1.93437273
83Triphalangeal thumb (HP:0001199)1.93178178
84Heterotopia (HP:0002282)1.92381210
85Missing ribs (HP:0000921)1.91171121
86Horseshoe kidney (HP:0000085)1.90961290
87Neoplasm of the colon (HP:0100273)1.88282601
88Carpal bone hypoplasia (HP:0001498)1.87859484
89Cortical dysplasia (HP:0002539)1.86190406
90Abnormality of the renal collecting system (HP:0004742)1.86034648
91Ovarian neoplasm (HP:0100615)1.85564650
92Aplasia/Hypoplasia of the earlobes (HP:0009906)1.85184501
93Facial cleft (HP:0002006)1.85026398
94Tracheoesophageal fistula (HP:0002575)1.83269679
95Clubbing of toes (HP:0100760)1.81112230
96Obsessive-compulsive behavior (HP:0000722)1.80954823
97Trigonocephaly (HP:0000243)1.79788692
98Septo-optic dysplasia (HP:0100842)1.79739196
99Neoplasm of the pancreas (HP:0002894)1.78179734
100Basal cell carcinoma (HP:0002671)1.76796619
101Broad thumb (HP:0011304)1.74134946
102Degeneration of anterior horn cells (HP:0002398)1.73903695
103Abnormality of the anterior horn cell (HP:0006802)1.73903695
104Hypoplastic pelvis (HP:0008839)1.73663814
105Pancreatic islet-cell hyperplasia (HP:0004510)1.71880815
106Abnormality of the septum pellucidum (HP:0007375)1.71760873
107Arteriovenous malformation (HP:0100026)1.71116794
108Esophageal atresia (HP:0002032)1.70488030
109High anterior hairline (HP:0009890)1.70380543
110Hypopigmentation of the fundus (HP:0007894)1.70075475
111Small hand (HP:0200055)1.70023777
112Rib fusion (HP:0000902)1.69794148
113Broad palm (HP:0001169)1.69514333
114Holoprosencephaly (HP:0001360)1.68579481
115Choanal atresia (HP:0000453)1.66974088
116Hemivertebrae (HP:0002937)1.66738451
117Preaxial hand polydactyly (HP:0001177)1.66352602
118Gastrointestinal atresia (HP:0002589)1.64840976
119Dandy-Walker malformation (HP:0001305)1.59899960
120Abnormality of cochlea (HP:0000375)1.59795282
121Bifid tongue (HP:0010297)1.59677132
122Absent septum pellucidum (HP:0001331)1.58169595
123Abnormality of the calcaneus (HP:0008364)1.58059766
124Abnormality of the proximal phalanges of the hand (HP:0009834)1.56208969
125Cerebellar dysplasia (HP:0007033)1.56104359
126Microtia (HP:0008551)1.55590838
127Abnormality of the phalanges of the hallux (HP:0010057)1.55134227
128Aqueductal stenosis (HP:0002410)1.55013311
129Astigmatism (HP:0000483)1.54536383
130Abnormal auditory evoked potentials (HP:0006958)1.52583045
131Progressive external ophthalmoplegia (HP:0000590)1.51065956
132Urethral obstruction (HP:0000796)1.50330704
133Cystic hygroma (HP:0000476)1.49603852
134Facial asymmetry (HP:0000324)1.49270436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.43703580
2BUB13.87872612
3CDK123.85170545
4NEK23.75927311
5WEE13.62271884
6TTK3.15741796
7BRSK22.56240565
8NEK12.50684352
9SRPK12.37102893
10PLK12.36691492
11PLK42.35861176
12AURKB2.15768273
13LATS12.11390345
14CHEK22.00372594
15PLK31.94558116
16MKNK11.91649821
17ATR1.88254872
18BRD41.84861083
19TAF11.79167257
20TLK11.79079886
21EIF2AK11.71230125
22ACVR1B1.70507647
23STK41.64563745
24BRSK11.59733428
25CHEK11.59300572
26MKNK21.58027898
27CDK71.55992628
28STK31.54451812
29CDK41.48383413
30MELK1.45991457
31STK101.45160709
32MAP3K81.39795007
33ATM1.37005497
34ZAK1.36868534
35RPS6KB21.32595480
36PASK1.32052514
37EEF2K1.26998400
38CDK61.24549363
39VRK11.22395473
40RPS6KA41.16849475
41AURKA1.16000604
42VRK21.11914045
43STK38L1.06305136
44WNK31.02648232
45* CDK21.02245858
46DYRK31.00179947
47CDK10.98832855
48CCNB10.98208419
49MAP3K100.93854542
50TSSK60.92670667
51CDK90.90648827
52TRIM280.89223290
53TGFBR10.85010142
54PKN20.82392778
55LATS20.82132933
56PBK0.76056548
57PNCK0.73441981
58PAK40.71775098
59SCYL20.70957308
60TNIK0.69988640
61MTOR0.69462576
62CDK80.68591983
63PLK20.66263129
64MST1R0.65454942
65NUAK10.63474357
66EPHA20.59585577
67PIM10.59361232
68BMPR1B0.58682143
69EIF2AK20.56409981
70PRKDC0.55715931
71RPS6KA50.54638168
72CDK30.52796814
73CSNK1D0.51051583
74ALK0.50183968
75CLK10.49435384
76MAPK140.48500529
77BRAF0.48455929
78MARK30.48232609
79CAMK1D0.47975568
80CSNK2A20.46789223
81PDK20.44373652
82CAMK1G0.43798786
83CSNK2A10.43103811
84FGFR10.41346376
85MST40.41275973
86PKN10.39619441
87AKT10.39076638
88CSNK1E0.38342781
89MET0.36878178
90PAK10.36677140
91FLT30.36661071
92CDK180.36425783
93GSK3B0.36114391
94BCR0.35861398
95AKT20.35622556
96UHMK10.35374700
97MAP3K40.34196959
98CDK150.34034120
99TTN0.33960441
100TESK20.33520072
101MAPK130.31933836
102MAPK10.31755286
103EIF2AK30.31682059
104CDK11A0.31385320
105ERBB20.30379478
106STK390.28234188
107FGFR20.28079624
108DMPK0.27969269
109CHUK0.27490847
110PDK30.25347448
111PDK40.25347448
112MAP3K60.23894075
113SMG10.23153678
114CDK140.22984585
115EPHB20.21514325
116ERBB30.20784551
117PDGFRA0.20411889
118LRRK20.20014063
119PAK20.19680325
120PRKCI0.19402768
121STK160.19317659
122CSNK1A1L0.19074819
123ERBB40.18713957
124YES10.17977362
125NEK90.15650826
126MAPK100.15337573
127ICK0.15017378
128RPS6KA10.14924589

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28303004
2Mismatch repair_Homo sapiens_hsa034304.08611949
3Cell cycle_Homo sapiens_hsa041103.81611266
4Homologous recombination_Homo sapiens_hsa034403.32568474
5RNA transport_Homo sapiens_hsa030133.21226309
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19728086
7Spliceosome_Homo sapiens_hsa030403.17957109
8Fanconi anemia pathway_Homo sapiens_hsa034603.10963099
9Base excision repair_Homo sapiens_hsa034102.85962581
10Non-homologous end-joining_Homo sapiens_hsa034502.64026081
11Nucleotide excision repair_Homo sapiens_hsa034202.61693375
12Systemic lupus erythematosus_Homo sapiens_hsa053222.47381996
13mRNA surveillance pathway_Homo sapiens_hsa030152.34417021
14One carbon pool by folate_Homo sapiens_hsa006702.23763301
15RNA degradation_Homo sapiens_hsa030182.22055063
16Basal transcription factors_Homo sapiens_hsa030222.16881958
17RNA polymerase_Homo sapiens_hsa030202.02454366
18p53 signaling pathway_Homo sapiens_hsa041152.01072425
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98361127
20Oocyte meiosis_Homo sapiens_hsa041141.74569571
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.74541518
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68461842
23Ribosome_Homo sapiens_hsa030101.61854959
24Pyrimidine metabolism_Homo sapiens_hsa002401.60801838
25MicroRNAs in cancer_Homo sapiens_hsa052061.48847210
26Viral carcinogenesis_Homo sapiens_hsa052031.44415255
27Basal cell carcinoma_Homo sapiens_hsa052171.21054134
28Alcoholism_Homo sapiens_hsa050341.19236723
29Protein export_Homo sapiens_hsa030601.17374200
30HTLV-I infection_Homo sapiens_hsa051661.13275054
31Herpes simplex infection_Homo sapiens_hsa051681.10534002
32Epstein-Barr virus infection_Homo sapiens_hsa051691.10378183
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09254967
34Small cell lung cancer_Homo sapiens_hsa052221.09138919
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08215488
36Proteasome_Homo sapiens_hsa030501.07431378
37TGF-beta signaling pathway_Homo sapiens_hsa043501.06744645
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05666554
39Hippo signaling pathway_Homo sapiens_hsa043901.03806745
40Lysine degradation_Homo sapiens_hsa003101.02255157
41Adherens junction_Homo sapiens_hsa045200.99195238
42Colorectal cancer_Homo sapiens_hsa052100.93865823
43Thyroid cancer_Homo sapiens_hsa052160.91672956
44Pyruvate metabolism_Homo sapiens_hsa006200.91503480
45Steroid biosynthesis_Homo sapiens_hsa001000.86496030
46Notch signaling pathway_Homo sapiens_hsa043300.80315445
47Hedgehog signaling pathway_Homo sapiens_hsa043400.79663175
48Purine metabolism_Homo sapiens_hsa002300.79528325
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77870898
50Propanoate metabolism_Homo sapiens_hsa006400.74668804
51Antigen processing and presentation_Homo sapiens_hsa046120.72185431
52Selenocompound metabolism_Homo sapiens_hsa004500.70638182
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70248165
54Chronic myeloid leukemia_Homo sapiens_hsa052200.69922946
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69786696
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67279016
57Vitamin B6 metabolism_Homo sapiens_hsa007500.66427508
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66255222
59Folate biosynthesis_Homo sapiens_hsa007900.65874708
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65307011
61Prostate cancer_Homo sapiens_hsa052150.65302280
62Pathways in cancer_Homo sapiens_hsa052000.62331795
63Wnt signaling pathway_Homo sapiens_hsa043100.58980458
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58584175
65Viral myocarditis_Homo sapiens_hsa054160.58394295
66Pancreatic cancer_Homo sapiens_hsa052120.57858415
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55235083
68FoxO signaling pathway_Homo sapiens_hsa040680.54670300
69mTOR signaling pathway_Homo sapiens_hsa041500.54045540
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51603141
71Endometrial cancer_Homo sapiens_hsa052130.51573071
72Hepatitis B_Homo sapiens_hsa051610.50334949
73Huntingtons disease_Homo sapiens_hsa050160.49318274
74Tight junction_Homo sapiens_hsa045300.48771336
75Non-small cell lung cancer_Homo sapiens_hsa052230.48349225
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47738863
77Carbon metabolism_Homo sapiens_hsa012000.47699879
78Proteoglycans in cancer_Homo sapiens_hsa052050.47250888
79Bladder cancer_Homo sapiens_hsa052190.46409298
80Melanoma_Homo sapiens_hsa052180.40850067
81Glutathione metabolism_Homo sapiens_hsa004800.40562831
82Apoptosis_Homo sapiens_hsa042100.40276558
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.39669964
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38812082
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37658739
86Dorso-ventral axis formation_Homo sapiens_hsa043200.37100562
87Influenza A_Homo sapiens_hsa051640.34760621
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34664487
89HIF-1 signaling pathway_Homo sapiens_hsa040660.32633543
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31733389
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31546962
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30917132
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30199199
94Melanogenesis_Homo sapiens_hsa049160.29123347
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.28888274
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27981926
97ECM-receptor interaction_Homo sapiens_hsa045120.27648754
98Focal adhesion_Homo sapiens_hsa045100.27415759
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26240185
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25886067
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25874726
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.23942117
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23783544
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.21830656
105Biosynthesis of amino acids_Homo sapiens_hsa012300.20879948
106Legionellosis_Homo sapiens_hsa051340.20663104
107Renal cell carcinoma_Homo sapiens_hsa052110.20372991
108Measles_Homo sapiens_hsa051620.19870091
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19829724
110Shigellosis_Homo sapiens_hsa051310.19559739
111Metabolic pathways_Homo sapiens_hsa011000.19210974
112Fatty acid metabolism_Homo sapiens_hsa012120.18763329
113Pentose phosphate pathway_Homo sapiens_hsa000300.16718302
114Fatty acid elongation_Homo sapiens_hsa000620.15731647
115AMPK signaling pathway_Homo sapiens_hsa041520.15250354
116Fatty acid biosynthesis_Homo sapiens_hsa000610.15166825
117Glioma_Homo sapiens_hsa052140.14515024
118Hematopoietic cell lineage_Homo sapiens_hsa046400.13970842
119Acute myeloid leukemia_Homo sapiens_hsa052210.13960037
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12127267
121Parkinsons disease_Homo sapiens_hsa050120.11589490
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11506599
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.11406830
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10185725
125Primary immunodeficiency_Homo sapiens_hsa053400.10100745
126Axon guidance_Homo sapiens_hsa043600.09127516
127N-Glycan biosynthesis_Homo sapiens_hsa005100.08771702
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.08763071
129Prolactin signaling pathway_Homo sapiens_hsa049170.07742714
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07536852
131Toxoplasmosis_Homo sapiens_hsa051450.07311786
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06946693

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