CENPK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)6.19741569
2telomere maintenance via semi-conservative replication (GO:0032201)6.13868229
3DNA strand elongation (GO:0022616)5.94551476
4* CENP-A containing nucleosome assembly (GO:0034080)5.64956312
5telomere maintenance via recombination (GO:0000722)5.59148680
6DNA replication checkpoint (GO:0000076)5.58548176
7DNA replication initiation (GO:0006270)5.53448766
8* chromatin remodeling at centromere (GO:0031055)5.48329298
9kinetochore organization (GO:0051383)5.43975982
10mitotic recombination (GO:0006312)5.36849384
11DNA unwinding involved in DNA replication (GO:0006268)5.06713291
12kinetochore assembly (GO:0051382)4.84379888
13* DNA replication-independent nucleosome assembly (GO:0006336)4.83320158
14* DNA replication-independent nucleosome organization (GO:0034724)4.83320158
15telomere maintenance via telomere lengthening (GO:0010833)4.74184448
16ribosomal small subunit assembly (GO:0000028)4.74179616
17nucleotide-excision repair, DNA gap filling (GO:0006297)4.61143177
18protein localization to kinetochore (GO:0034501)4.53330244
19* histone exchange (GO:0043486)4.46079747
20attachment of spindle microtubules to kinetochore (GO:0008608)4.37673673
21DNA deamination (GO:0045006)4.34434679
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.30871377
23nucleobase biosynthetic process (GO:0046112)4.21301770
24mitotic metaphase plate congression (GO:0007080)4.20630693
25replication fork processing (GO:0031297)4.17349315
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14401657
27mitotic chromosome condensation (GO:0007076)4.12956563
28negative regulation of DNA-dependent DNA replication (GO:2000104)4.10201492
29protein localization to chromosome, centromeric region (GO:0071459)4.08851494
30purine nucleobase biosynthetic process (GO:0009113)4.04262087
31DNA replication-dependent nucleosome assembly (GO:0006335)4.03673515
32DNA replication-dependent nucleosome organization (GO:0034723)4.03673515
33DNA double-strand break processing (GO:0000729)4.02386261
34centriole replication (GO:0007099)3.96484993
35proteasome assembly (GO:0043248)3.92339691
36metaphase plate congression (GO:0051310)3.90640870
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90003068
38protein K6-linked ubiquitination (GO:0085020)3.88250490
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.83985969
40maturation of SSU-rRNA (GO:0030490)3.81677689
41deoxyribonucleotide biosynthetic process (GO:0009263)3.79094413
42synapsis (GO:0007129)3.76964066
43regulation of centriole replication (GO:0046599)3.75929828
44meiotic chromosome segregation (GO:0045132)3.73128578
45mitotic sister chromatid segregation (GO:0000070)3.71277321
46viral transcription (GO:0019083)3.67788341
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.67054348
48translational termination (GO:0006415)3.64268272
49telomere maintenance (GO:0000723)3.59167386
50telomere organization (GO:0032200)3.57243639
51IMP biosynthetic process (GO:0006188)3.54523038
52establishment of chromosome localization (GO:0051303)3.53580399
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.53475043
54ribosomal small subunit biogenesis (GO:0042274)3.49599497
55microtubule depolymerization (GO:0007019)3.48520200
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47103248
57regulation of mitotic spindle checkpoint (GO:1903504)3.47103248
58formation of translation preinitiation complex (GO:0001731)3.46450140
59sister chromatid segregation (GO:0000819)3.46170243
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44776185
61mitotic nuclear envelope disassembly (GO:0007077)3.44566037
62ATP synthesis coupled proton transport (GO:0015986)3.42700093
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42700093
64response to pheromone (GO:0019236)3.42331782
65transcription-coupled nucleotide-excision repair (GO:0006283)3.41060107
66spliceosomal snRNP assembly (GO:0000387)3.39310277
67* chromatin assembly or disassembly (GO:0006333)3.38341353
68recombinational repair (GO:0000725)3.36409901
69pseudouridine synthesis (GO:0001522)3.33716427
70cell cycle G1/S phase transition (GO:0044843)3.33597888
71G1/S transition of mitotic cell cycle (GO:0000082)3.33597888
72double-strand break repair via homologous recombination (GO:0000724)3.32689046
73translational elongation (GO:0006414)3.31577405
74chromosome segregation (GO:0007059)3.31564706
75DNA catabolic process, exonucleolytic (GO:0000738)3.31421616
76regulation of spindle organization (GO:0090224)3.30952055
77translesion synthesis (GO:0019985)3.28215180
78resolution of meiotic recombination intermediates (GO:0000712)3.25163957
79postreplication repair (GO:0006301)3.25162452
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23643565
81mitotic sister chromatid cohesion (GO:0007064)3.23565907
82viral mRNA export from host cell nucleus (GO:0046784)3.23044737
83regulation of DNA endoreduplication (GO:0032875)3.22932688
84deoxyribose phosphate biosynthetic process (GO:0046385)3.21076426
852-deoxyribonucleotide biosynthetic process (GO:0009265)3.21076426
86* ATP-dependent chromatin remodeling (GO:0043044)3.19229477
87spindle checkpoint (GO:0031577)3.18112192
88ribosomal large subunit biogenesis (GO:0042273)3.17042968
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.16183052
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16183052
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16183052
92negative regulation of sister chromatid segregation (GO:0033046)3.16183052
93cotranslational protein targeting to membrane (GO:0006613)3.15785511
94folic acid-containing compound biosynthetic process (GO:0009396)3.15571776
95nuclear envelope disassembly (GO:0051081)3.14919139
96membrane disassembly (GO:0030397)3.14919139
97mismatch repair (GO:0006298)3.14778195
98protein neddylation (GO:0045116)3.14669870
99translational initiation (GO:0006413)3.13855760
100protein targeting to ER (GO:0045047)3.12912144
101somatic hypermutation of immunoglobulin genes (GO:0016446)3.12431121
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12431121
103IMP metabolic process (GO:0046040)3.12346122
104negative regulation of chromosome segregation (GO:0051985)3.12237999
105regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11221396
106DNA replication (GO:0006260)3.11177667
107* mitotic cell cycle (GO:0000278)3.10752005
108regulation of chromosome segregation (GO:0051983)3.10249604
109ribonucleoprotein complex biogenesis (GO:0022613)3.09428640
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08751491
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08230400
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07698567
113histone-serine phosphorylation (GO:0035404)3.07021706
114spindle assembly checkpoint (GO:0071173)3.06895596
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06577257
116negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06453598
117pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06002974
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05668453
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05255613
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04777968
121rRNA processing (GO:0006364)3.02902271
122DNA ligation (GO:0006266)3.01965941
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01809937
124mitotic G2/M transition checkpoint (GO:0044818)3.01009249
125spliceosomal complex assembly (GO:0000245)2.98341829
126protein localization to chromosome (GO:0034502)2.96602654
127regulation of centrosome cycle (GO:0046605)2.96534301
128histone mRNA metabolic process (GO:0008334)2.96351082
129DNA topological change (GO:0006265)2.96271599
130establishment of integrated proviral latency (GO:0075713)2.95607393
131centrosome organization (GO:0051297)2.95314235
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.92506276
133NADH dehydrogenase complex assembly (GO:0010257)2.92506276
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92506276
135reciprocal meiotic recombination (GO:0007131)2.92179327
136reciprocal DNA recombination (GO:0035825)2.92179327
137mitotic spindle checkpoint (GO:0071174)2.91387391
138mitochondrial respiratory chain complex assembly (GO:0033108)2.91339165
139protein complex biogenesis (GO:0070271)2.90036269
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87005627
141centriole assembly (GO:0098534)2.84400929
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84198568
143DNA strand renaturation (GO:0000733)2.83723832
144DNA recombination (GO:0006310)2.81596298
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80961889
146negative regulation of ligase activity (GO:0051352)2.80961889
147maturation of 5.8S rRNA (GO:0000460)2.78620334
148microtubule polymerization or depolymerization (GO:0031109)2.78546370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.57927145
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42970997
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11058613
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71065412
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.60744222
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58913201
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.04238164
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.78450606
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74136484
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69090243
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67776311
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67741073
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62708369
14AR_21909140_ChIP-Seq_LNCAP_Human2.61517304
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59697648
16ZNF274_21170338_ChIP-Seq_K562_Hela2.56432025
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54279026
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.53390543
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.52240438
20VDR_22108803_ChIP-Seq_LS180_Human2.43895831
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.33743954
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27541944
23VDR_23849224_ChIP-Seq_CD4+_Human2.24388908
24XRN2_22483619_ChIP-Seq_HELA_Human2.23794900
25EWS_26573619_Chip-Seq_HEK293_Human2.22518436
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22299476
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14909826
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14738031
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13516053
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03692167
31FOXP3_21729870_ChIP-Seq_TREG_Human2.01565267
32E2F7_22180533_ChIP-Seq_HELA_Human10.7384667
33DCP1A_22483619_ChIP-Seq_HELA_Human1.99248332
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97425182
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95127999
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94727166
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89355687
38FUS_26573619_Chip-Seq_HEK293_Human1.89089791
39* TTF2_22483619_ChIP-Seq_HELA_Human1.80929318
40ELK1_19687146_ChIP-ChIP_HELA_Human1.77619266
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74845945
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73872005
43GABP_19822575_ChIP-Seq_HepG2_Human1.73537708
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73120578
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68386024
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66846388
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.66272727
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65817854
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65732285
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64360250
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63441022
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62763253
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.52103654
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47611858
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46698935
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46430173
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46245603
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44306367
59IRF1_19129219_ChIP-ChIP_H3396_Human1.43521509
60TAF15_26573619_Chip-Seq_HEK293_Human1.40166691
61CIITA_25753668_ChIP-Seq_RAJI_Human1.40147651
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39293391
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35874463
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34503094
65P300_19829295_ChIP-Seq_ESCs_Human1.33757157
66IGF1R_20145208_ChIP-Seq_DFB_Human1.32859541
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.32586844
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31982615
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31975033
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31626833
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31449945
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31377050
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.30395946
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29928143
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29370211
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28634528
77KDM5A_27292631_Chip-Seq_BREAST_Human1.27646134
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.24898871
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24655468
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23210593
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20572941
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19620201
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.17955110
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17659952
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14341177
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14260776
87MYC_22102868_ChIP-Seq_BL_Human1.13428274
88MYC_18940864_ChIP-ChIP_HL60_Human1.12607636
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09815468
90ER_23166858_ChIP-Seq_MCF-7_Human1.06068571
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05474484
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02650903
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.02586454
94EZH2_22144423_ChIP-Seq_EOC_Human1.00338064
95GBX2_23144817_ChIP-Seq_PC3_Human0.99732277
96SPI1_23547873_ChIP-Seq_NB4_Human0.99491170
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98565355
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97120155
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96543991
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95602473
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95186287
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95096977
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94953659
104EZH2_27294783_Chip-Seq_NPCs_Mouse0.94866874
105VDR_21846776_ChIP-Seq_THP-1_Human0.94361536
106TP53_22573176_ChIP-Seq_HFKS_Human0.93302884
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92950816
108FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92845330
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.92845330
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.91539077
111NFE2_27457419_Chip-Seq_LIVER_Mouse0.90545330
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89308728
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88149006
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87975168
115IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86888077
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86659911
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85942328
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85137989
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83900811
120SOX2_19829295_ChIP-Seq_ESCs_Human0.83317792
121NANOG_19829295_ChIP-Seq_ESCs_Human0.83317792
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81636723
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81088128
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80504934
125TFEB_21752829_ChIP-Seq_HELA_Human0.79548548
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79248172
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78990267
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78056235
129CBP_20019798_ChIP-Seq_JUKART_Human0.78056235
130* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73683305
131SCL_19346495_ChIP-Seq_HPC-7_Human0.73246431
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71157257
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.68838990
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68780972
135MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68378576
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.67881811
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66892571
138* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66260985
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66136499
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.61257408
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.61239813
142* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.59509687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.58209101
2MP0010094_abnormal_chromosome_stability5.49244398
3MP0008057_abnormal_DNA_replication4.85435458
4MP0003111_abnormal_nucleus_morphology4.71079849
5MP0004957_abnormal_blastocyst_morpholog4.44356310
6MP0003077_abnormal_cell_cycle4.32021914
7MP0008058_abnormal_DNA_repair3.64475949
8MP0002396_abnormal_hematopoietic_system3.25361454
9MP0008007_abnormal_cellular_replicative3.07643228
10MP0003136_yellow_coat_color2.95018789
11MP0008932_abnormal_embryonic_tissue2.81929322
12MP0008877_abnormal_DNA_methylation2.38382546
13MP0004147_increased_porphyrin_level2.29307002
14MP0003123_paternal_imprinting2.14280034
15MP0003786_premature_aging2.06478264
16MP0000350_abnormal_cell_proliferation2.06196764
17MP0000490_abnormal_crypts_of2.00115496
18MP0006072_abnormal_retinal_apoptosis1.97006123
19MP0001730_embryonic_growth_arrest1.92772697
20MP0004808_abnormal_hematopoietic_stem1.92300851
21MP0009379_abnormal_foot_pigmentation1.88647705
22MP0006054_spinal_hemorrhage1.85647099
23MP0001529_abnormal_vocalization1.68492959
24MP0010307_abnormal_tumor_latency1.68353631
25MP0002736_abnormal_nociception_after1.58683912
26MP0002019_abnormal_tumor_incidence1.56861109
27MP0000313_abnormal_cell_death1.56538832
28MP0001545_abnormal_hematopoietic_system1.49953800
29MP0005397_hematopoietic_system_phenotyp1.49953800
30MP0003656_abnormal_erythrocyte_physiolo1.48367033
31MP0003937_abnormal_limbs/digits/tail_de1.45239266
32MP0003195_calcinosis1.45178361
33MP0003763_abnormal_thymus_physiology1.44071767
34MP0001697_abnormal_embryo_size1.41934995
35MP0009697_abnormal_copulation1.41649871
36MP0004133_heterotaxia1.40044398
37MP0000372_irregular_coat_pigmentation1.39011395
38MP0003718_maternal_effect1.38464508
39MP0001672_abnormal_embryogenesis/_devel1.37026718
40MP0005380_embryogenesis_phenotype1.37026718
41MP0002080_prenatal_lethality1.36045349
42MP0009333_abnormal_splenocyte_physiolog1.35330386
43MP0002398_abnormal_bone_marrow1.34127771
44MP0001485_abnormal_pinna_reflex1.33487265
45MP0003119_abnormal_digestive_system1.31980806
46MP0002160_abnormal_reproductive_system1.31679099
47MP0005551_abnormal_eye_electrophysiolog1.31027584
48MP0002210_abnormal_sex_determination1.30667319
49MP0001286_abnormal_eye_development1.27114737
50MP0003186_abnormal_redox_activity1.26448503
51MP0010352_gastrointestinal_tract_polyps1.23347524
52MP0005253_abnormal_eye_physiology1.22028378
53MP0010030_abnormal_orbit_morphology1.21610211
54MP0005174_abnormal_tail_pigmentation1.20600594
55MP0000631_abnormal_neuroendocrine_gland1.20169341
56MP0003890_abnormal_embryonic-extraembry1.20068826
57MP0003984_embryonic_growth_retardation1.19704302
58MP0000689_abnormal_spleen_morphology1.18832207
59MP0002722_abnormal_immune_system1.18246604
60MP0003787_abnormal_imprinting1.18005243
61MP0000703_abnormal_thymus_morphology1.17369650
62MP0003567_abnormal_fetal_cardiomyocyte1.17342547
63MP0001929_abnormal_gametogenesis1.16849645
64MP0005084_abnormal_gallbladder_morpholo1.16813383
65MP0002088_abnormal_embryonic_growth/wei1.14849347
66MP0001835_abnormal_antigen_presentation1.13234339
67MP0003806_abnormal_nucleotide_metabolis1.12771875
68MP0001145_abnormal_male_reproductive1.12430192
69MP0001968_abnormal_touch/_nociception1.12205484
70MP0008872_abnormal_physiological_respon1.11597989
71MP0002095_abnormal_skin_pigmentation1.10217750
72MP0003121_genomic_imprinting1.09913116
73MP0002085_abnormal_embryonic_tissue1.08476353
74MP0006036_abnormal_mitochondrial_physio1.07497606
75MP0001853_heart_inflammation1.06045441
76MP0000569_abnormal_digit_pigmentation1.05850996
77MP0002653_abnormal_ependyma_morphology1.05536501
78MP0002638_abnormal_pupillary_reflex1.05107663
79MP0002429_abnormal_blood_cell1.04966059
80MP0001919_abnormal_reproductive_system1.04238910
81MP0002277_abnormal_respiratory_mucosa1.04028556
82MP0004142_abnormal_muscle_tone1.02443540
83MP0008789_abnormal_olfactory_epithelium1.02426265
84MP0000653_abnormal_sex_gland1.00882312
85MP0002086_abnormal_extraembryonic_tissu1.00337738
86MP0002234_abnormal_pharynx_morphology1.00303778
87MP0002751_abnormal_autonomic_nervous1.00083919
88MP0000647_abnormal_sebaceous_gland0.99888524
89MP0003880_abnormal_central_pattern0.99104088
90MP0000427_abnormal_hair_cycle0.98911367
91MP0001119_abnormal_female_reproductive0.97958116
92MP0002132_abnormal_respiratory_system0.96714048
93MP0002006_tumorigenesis0.95313104
94MP0006292_abnormal_olfactory_placode0.94055642
95MP0005389_reproductive_system_phenotype0.93915769
96MP0006035_abnormal_mitochondrial_morpho0.92997755
97MP0004197_abnormal_fetal_growth/weight/0.92431560
98MP0005171_absent_coat_pigmentation0.91311041
99MP0003315_abnormal_perineum_morphology0.91026389
100MP0003941_abnormal_skin_development0.90958501
101MP0000716_abnormal_immune_system0.90096111
102MP0002837_dystrophic_cardiac_calcinosis0.89085709
103MP0003646_muscle_fatigue0.88719120
104MP0005075_abnormal_melanosome_morpholog0.87809829
105MP0002084_abnormal_developmental_patter0.87145688
106MP0001188_hyperpigmentation0.85465053
107MP0005391_vision/eye_phenotype0.84502070
108MP0000049_abnormal_middle_ear0.83656521
109MP0001293_anophthalmia0.83474843
110MP0000858_altered_metastatic_potential0.83345891
111MP0003011_delayed_dark_adaptation0.81864749
112MP0001324_abnormal_eye_pigmentation0.81456438
113MP0005671_abnormal_response_to0.80826630
114MP0005195_abnormal_posterior_eye0.79584041
115MP0002233_abnormal_nose_morphology0.79064840
116MP0004742_abnormal_vestibular_system0.76925550
117MP0002420_abnormal_adaptive_immunity0.76852133
118MP0002166_altered_tumor_susceptibility0.76112057
119MP0005646_abnormal_pituitary_gland0.75913858
120MP0005395_other_phenotype0.75170401
121MP0001819_abnormal_immune_cell0.74920879
122MP0009046_muscle_twitch0.74848421
123MP0002102_abnormal_ear_morphology0.74830458
124MP0002697_abnormal_eye_size0.74753915
125MP0004885_abnormal_endolymph0.73564561
126MP0009745_abnormal_behavioral_response0.71183480
127MP0003861_abnormal_nervous_system0.69632249
128MP0003878_abnormal_ear_physiology0.69614505
129MP0005377_hearing/vestibular/ear_phenot0.69614505
130MP0000015_abnormal_ear_pigmentation0.69173681
131MP0002161_abnormal_fertility/fecundity0.68737656
132MP0002452_abnormal_antigen_presenting0.67326719
133MP0001800_abnormal_humoral_immune0.65748728
134MP0000358_abnormal_cell_content/0.64415612
135MP0001764_abnormal_homeostasis0.62402269
136MP0005384_cellular_phenotype0.62028042
137MP0009785_altered_susceptibility_to0.60488875
138MP0001915_intracranial_hemorrhage0.58879098
139MP0005025_abnormal_response_to0.57528164
140MP0000477_abnormal_intestine_morphology0.56407463
141MP0005266_abnormal_metabolism0.56261055
142MP0003698_abnormal_male_reproductive0.55170252
143MP0002405_respiratory_system_inflammati0.54874195
144MP0005621_abnormal_cell_physiology0.54864387
145MP0002723_abnormal_immune_serum0.54752639
146MP0009672_abnormal_birth_weight0.54747560
147MP0005076_abnormal_cell_differentiation0.54582652
148MP0008995_early_reproductive_senescence0.54305906
149MP0005408_hypopigmentation0.54255545
150MP0000465_gastrointestinal_hemorrhage0.52882742
151MP0002111_abnormal_tail_morphology0.52433170
152MP0003221_abnormal_cardiomyocyte_apopto0.51156202
153MP0002938_white_spotting0.49834585
154MP0002075_abnormal_coat/hair_pigmentati0.47922048

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.75262516
2Reticulocytopenia (HP:0001896)5.42498327
3Chromsome breakage (HP:0040012)5.16554165
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.01788566
5Abnormal number of erythroid precursors (HP:0012131)4.69002145
6Abnormality of cells of the erythroid lineage (HP:0012130)4.67553611
7Oral leukoplakia (HP:0002745)4.20707344
8Aplastic anemia (HP:0001915)4.12640318
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.86363897
10Breast hypoplasia (HP:0003187)3.71301988
11Abnormality of chromosome stability (HP:0003220)3.66887487
12Meckel diverticulum (HP:0002245)3.54053862
13Abnormality of the preputium (HP:0100587)3.52008133
14Pallor (HP:0000980)3.33567592
15Abnormality of the ileum (HP:0001549)3.31452413
16Patellar aplasia (HP:0006443)3.31262970
17Macrocytic anemia (HP:0001972)3.27653635
18Colon cancer (HP:0003003)3.25072421
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.21635352
2011 pairs of ribs (HP:0000878)3.19052362
21Acute necrotizing encephalopathy (HP:0006965)3.08675582
22Duplicated collecting system (HP:0000081)3.07351552
23Aplasia/Hypoplasia of the patella (HP:0006498)3.06849268
24Pancreatic cysts (HP:0001737)3.03733762
25Small intestinal stenosis (HP:0012848)3.00028788
26Duodenal stenosis (HP:0100867)3.00028788
27Abnormality of the labia minora (HP:0012880)2.99791237
28Pancreatic fibrosis (HP:0100732)2.94564224
29Myelodysplasia (HP:0002863)2.91848647
30Molar tooth sign on MRI (HP:0002419)2.89731006
31Abnormality of midbrain morphology (HP:0002418)2.89731006
32Increased hepatocellular lipid droplets (HP:0006565)2.88252930
33Abnormality of the renal collecting system (HP:0004742)2.84470736
34Acute encephalopathy (HP:0006846)2.82390753
35Absent thumb (HP:0009777)2.79225091
36True hermaphroditism (HP:0010459)2.78634422
37Pancytopenia (HP:0001876)2.72399314
38Exertional dyspnea (HP:0002875)2.72227870
39Bone marrow hypocellularity (HP:0005528)2.71447175
40Rough bone trabeculation (HP:0100670)2.68564429
41Poor head control (HP:0002421)2.60990111
42Abnormal mitochondria in muscle tissue (HP:0008316)2.60621060
43Lipid accumulation in hepatocytes (HP:0006561)2.58952159
44Congenital, generalized hypertrichosis (HP:0004540)2.58305444
45Impulsivity (HP:0100710)2.53613436
46Premature graying of hair (HP:0002216)2.51114460
47Progressive macrocephaly (HP:0004481)2.49671338
48Thrombocytosis (HP:0001894)2.49621970
49Septo-optic dysplasia (HP:0100842)2.49530476
50Medulloblastoma (HP:0002885)2.47906558
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46479309
52Abnormal lung lobation (HP:0002101)2.46168799
53Abnormality of pyrimidine metabolism (HP:0004353)2.45135065
54Abnormality of the pons (HP:0007361)2.43988945
55Nephronophthisis (HP:0000090)2.43640433
56Abnormality of alanine metabolism (HP:0010916)2.43031640
57Hyperalaninemia (HP:0003348)2.43031640
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43031640
59Clubbing of toes (HP:0100760)2.42612422
60Hypoplasia of the pons (HP:0012110)2.41274360
61Sloping forehead (HP:0000340)2.39502667
62Microretrognathia (HP:0000308)2.38990284
63Abnormality of DNA repair (HP:0003254)2.38653786
64Ectopic kidney (HP:0000086)2.36392771
65Abnormality of the duodenum (HP:0002246)2.35758047
66Absent radius (HP:0003974)2.33872588
67Abnormal spermatogenesis (HP:0008669)2.32756022
68Horseshoe kidney (HP:0000085)2.32013417
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30419306
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30419306
71Selective tooth agenesis (HP:0001592)2.28948332
72Abnormality of reticulocytes (HP:0004312)2.28648889
73Type I transferrin isoform profile (HP:0003642)2.28278245
74Pendular nystagmus (HP:0012043)2.27739237
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26800660
76Triphalangeal thumb (HP:0001199)2.23918473
77Sclerocornea (HP:0000647)2.20229479
78Degeneration of anterior horn cells (HP:0002398)2.19865385
79Abnormality of the anterior horn cell (HP:0006802)2.19865385
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19715417
81Lymphoma (HP:0002665)2.19279157
82Abnormality of the carotid arteries (HP:0005344)2.18223466
83Cellular immunodeficiency (HP:0005374)2.18158448
84Neoplasm of the pancreas (HP:0002894)2.18011358
85Aplasia involving forearm bones (HP:0009822)2.15250399
86Absent forearm bone (HP:0003953)2.15250399
87Agnosia (HP:0010524)2.14197618
88Carpal bone hypoplasia (HP:0001498)2.13058436
89Tracheoesophageal fistula (HP:0002575)2.12415408
90Abnormal trabecular bone morphology (HP:0100671)2.11937737
91Increased serum lactate (HP:0002151)2.11158822
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10935167
93Respiratory difficulties (HP:0002880)2.10359765
94Short thumb (HP:0009778)2.09895311
95Slender long bone (HP:0003100)2.09227597
96Megaloblastic anemia (HP:0001889)2.07973004
97Nephroblastoma (Wilms tumor) (HP:0002667)2.05897937
98Cleft eyelid (HP:0000625)2.03776871
99Cerebral edema (HP:0002181)2.03428613
100IgM deficiency (HP:0002850)2.03026071
101Papilledema (HP:0001085)2.02888909
102Increased intramyocellular lipid droplets (HP:0012240)2.02723422
103Neoplasm of the colon (HP:0100273)2.02241148
104Reduced antithrombin III activity (HP:0001976)1.98567628
105Abnormality of the renal medulla (HP:0100957)1.98525383
106Increased nuchal translucency (HP:0010880)1.97725640
107High pitched voice (HP:0001620)1.97659350
108Atresia of the external auditory canal (HP:0000413)1.97255501
109Absent septum pellucidum (HP:0001331)1.96594373
110Increased CSF lactate (HP:0002490)1.93522924
111Anencephaly (HP:0002323)1.93410426
112Abnormal number of incisors (HP:0011064)1.92276348
113Oligodactyly (hands) (HP:0001180)1.91710738
114Optic disc pallor (HP:0000543)1.90007416
115Embryonal renal neoplasm (HP:0011794)1.89148609
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88604973
117Congenital stationary night blindness (HP:0007642)1.87912491
118Bilateral microphthalmos (HP:0007633)1.87607761
119Pulmonary fibrosis (HP:0002206)1.87510312
120Optic nerve hypoplasia (HP:0000609)1.87119056
121Abnormality of serum amino acid levels (HP:0003112)1.85602433
122Hepatocellular necrosis (HP:0001404)1.85170770
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.85109294
124Basal cell carcinoma (HP:0002671)1.83829165
125Mitochondrial inheritance (HP:0001427)1.83752843
126Cerebral hypomyelination (HP:0006808)1.83244947
127Hyperglycinemia (HP:0002154)1.83045021
128Small hand (HP:0200055)1.81785312
129Medial flaring of the eyebrow (HP:0010747)1.80493667
130Cafe-au-lait spot (HP:0000957)1.78004592
131Supernumerary spleens (HP:0009799)1.77424615
132Dandy-Walker malformation (HP:0001305)1.77283273
133Hepatic necrosis (HP:0002605)1.77260791
134Anophthalmia (HP:0000528)1.76264898
135Type II lissencephaly (HP:0007260)1.75661762
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.75512408
137Oligohydramnios (HP:0001562)1.75341030
138Volvulus (HP:0002580)1.75073269
1393-Methylglutaconic aciduria (HP:0003535)1.74476937
140Abnormality of the renal cortex (HP:0011035)1.74153734
141Astigmatism (HP:0000483)1.73728773
142Chronic otitis media (HP:0000389)1.72911086
143Increased muscle lipid content (HP:0009058)1.72318704
144Renal Fanconi syndrome (HP:0001994)1.71856894
145Hyperglycinuria (HP:0003108)1.70041132
146Holoprosencephaly (HP:0001360)1.69896982
147Abnormality of the septum pellucidum (HP:0007375)1.69838290
148Abolished electroretinogram (ERG) (HP:0000550)1.69520004
149Preaxial hand polydactyly (HP:0001177)1.69090248
150Chronic hepatic failure (HP:0100626)1.68734654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.31430307
2WEE14.59655068
3BUB13.84886223
4EIF2AK13.40445037
5NEK13.09604115
6SRPK12.90912086
7VRK22.87446910
8NEK22.77995121
9ACVR1B2.77128903
10BRSK22.68349171
11PLK42.67790116
12BMPR1B2.59146025
13PNCK2.58126268
14STK162.56708313
15VRK12.34747324
16CCNB12.33887952
17PLK12.20322702
18TTK2.16584320
19MKNK12.14043451
20EIF2AK32.06997093
21NME21.96625838
22AURKB1.92848807
23WNK31.89240474
24TNIK1.85113947
25BRSK11.82994181
26ATR1.71433972
27TLK11.67546580
28PBK1.57264217
29TAF11.54578586
30MST41.53518971
31STK41.51354623
32PLK31.49632984
33FRK1.49133681
34CDK71.42920323
35DYRK31.42777358
36ZAK1.39664152
37CHEK21.37546339
38INSRR1.34796221
39ADRBK21.31243348
40MKNK21.29085726
41TRIM281.20316675
42MAP3K81.15638568
43AURKA1.14496699
44PASK1.13507653
45RPS6KA41.13133798
46CLK11.11462923
47CDK81.09969850
48CASK1.09158531
49TEC1.08515265
50GRK11.04180701
51SCYL21.03293303
52CHEK11.02750724
53MAP4K21.02701248
54PLK21.02149977
55TSSK61.00952823
56DYRK20.99712837
57TESK20.99424983
58RPS6KB20.96060716
59EIF2AK20.92923597
60MAP4K10.91439048
61PIM20.89102806
62MAPK130.88341710
63CDK40.87306929
64WNK40.78887850
65TGFBR10.77759214
66IRAK40.77338970
67ATM0.76943387
68STK100.76699935
69KIT0.75846954
70CSNK2A10.70886108
71CSNK1G30.69776477
72PIM10.68791200
73OXSR10.68126421
74MAP3K110.66384619
75BRD40.65137556
76CDK20.63888314
77CSNK2A20.62568154
78KDR0.60261202
79STK38L0.58559019
80BTK0.57914188
81LRRK20.57326027
82CDK10.55972977
83FLT30.55971014
84CDK30.55247033
85CDK60.54900814
86STK390.54703689
87MELK0.54427879
88BRAF0.53867632
89BCR0.53441145
90PAK40.51402582
91PRKCG0.50250517
92RPS6KA50.49622410
93MAP3K40.47550691
94ADRBK10.47265911
95YES10.45803319
96CSNK1A1L0.45294922
97MAPKAPK50.44753311
98BCKDK0.44195865
99MAPK150.43966306
100ERBB30.43670282
101LATS10.43035995
102CSNK1G10.42163227
103PINK10.41627090
104ERBB40.41562765
105MAP2K30.40288366
106BLK0.37767345
107LYN0.37623935
108TIE10.35485546
109NEK90.35201805
110CSF1R0.34166179
111TESK10.34163973
112MARK30.33968484
113PAK10.33751626
114TAOK20.32620015
115TAOK30.31759722
116MATK0.31351748
117ABL20.30089319
118NME10.28608506
119CSNK1E0.26007549
120PRKDC0.24990535
121NLK0.24886079
122SYK0.23606800
123RPS6KA60.23179747
124JAK30.23056039
125PKN10.23043032
126CDK120.21963904
127TXK0.21563031
128PRKCI0.20658103
129RPS6KC10.20609715
130RPS6KL10.20609715
131PDK30.20450347
132PDK40.20450347
133CSNK1G20.20396037
134MAP2K70.20142298
135TYK20.19877149
136MAP3K120.18447620
137CAMKK20.17501982
138CDK190.16266758
139MAP2K60.16222827
140NUAK10.15796497
141EEF2K0.15572794
142MAP3K100.15060683
143STK30.13883445

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.19114222
2Mismatch repair_Homo sapiens_hsa034305.11504379
3Ribosome_Homo sapiens_hsa030103.59236407
4Homologous recombination_Homo sapiens_hsa034403.50647292
5Base excision repair_Homo sapiens_hsa034103.44764356
6Proteasome_Homo sapiens_hsa030503.28042643
7Nucleotide excision repair_Homo sapiens_hsa034203.09946603
8Spliceosome_Homo sapiens_hsa030403.08616695
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98391675
10Cell cycle_Homo sapiens_hsa041102.90278198
11RNA polymerase_Homo sapiens_hsa030202.80354759
12Pyrimidine metabolism_Homo sapiens_hsa002402.72225779
13One carbon pool by folate_Homo sapiens_hsa006702.64965361
14RNA transport_Homo sapiens_hsa030132.63131663
15Fanconi anemia pathway_Homo sapiens_hsa034602.58614570
16Non-homologous end-joining_Homo sapiens_hsa034502.24731491
17RNA degradation_Homo sapiens_hsa030181.88894626
18p53 signaling pathway_Homo sapiens_hsa041151.67200632
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64164234
20Basal transcription factors_Homo sapiens_hsa030221.63156875
21Purine metabolism_Homo sapiens_hsa002301.48445249
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47635137
23Systemic lupus erythematosus_Homo sapiens_hsa053221.47116955
24Propanoate metabolism_Homo sapiens_hsa006401.40497587
25Phototransduction_Homo sapiens_hsa047441.35870138
26mRNA surveillance pathway_Homo sapiens_hsa030151.29100017
27Protein export_Homo sapiens_hsa030601.21355493
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19761600
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14253449
30Nitrogen metabolism_Homo sapiens_hsa009101.12156081
31Folate biosynthesis_Homo sapiens_hsa007901.06898564
32Butanoate metabolism_Homo sapiens_hsa006501.06668405
33Epstein-Barr virus infection_Homo sapiens_hsa051691.02689938
34Cardiac muscle contraction_Homo sapiens_hsa042600.99536055
35Oocyte meiosis_Homo sapiens_hsa041140.98550220
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98120325
37Steroid biosynthesis_Homo sapiens_hsa001000.96208620
38Huntingtons disease_Homo sapiens_hsa050160.92943385
39Parkinsons disease_Homo sapiens_hsa050120.90715891
40Herpes simplex infection_Homo sapiens_hsa051680.89828039
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89563688
42Pentose phosphate pathway_Homo sapiens_hsa000300.88034973
43Linoleic acid metabolism_Homo sapiens_hsa005910.86960612
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.83315073
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.81886859
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76763442
47Viral carcinogenesis_Homo sapiens_hsa052030.75454328
48Tryptophan metabolism_Homo sapiens_hsa003800.74837934
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74502103
50Caffeine metabolism_Homo sapiens_hsa002320.74051724
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.71236898
52Antigen processing and presentation_Homo sapiens_hsa046120.70999883
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.69724637
54Nicotine addiction_Homo sapiens_hsa050330.68157043
55N-Glycan biosynthesis_Homo sapiens_hsa005100.67802960
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66795476
57Basal cell carcinoma_Homo sapiens_hsa052170.64587097
58Glutathione metabolism_Homo sapiens_hsa004800.63397936
59Oxidative phosphorylation_Homo sapiens_hsa001900.62193190
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59032590
61Olfactory transduction_Homo sapiens_hsa047400.57555726
62Selenocompound metabolism_Homo sapiens_hsa004500.56851152
63HTLV-I infection_Homo sapiens_hsa051660.56703004
64Biosynthesis of amino acids_Homo sapiens_hsa012300.56120414
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56034213
66Small cell lung cancer_Homo sapiens_hsa052220.52568753
67Fatty acid elongation_Homo sapiens_hsa000620.52182966
68Alcoholism_Homo sapiens_hsa050340.50709471
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50561572
70Peroxisome_Homo sapiens_hsa041460.49891599
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48824031
72Legionellosis_Homo sapiens_hsa051340.48751329
73Hedgehog signaling pathway_Homo sapiens_hsa043400.48446781
74Primary immunodeficiency_Homo sapiens_hsa053400.47118061
75Taste transduction_Homo sapiens_hsa047420.43939072
76Alzheimers disease_Homo sapiens_hsa050100.42784582
77Vitamin B6 metabolism_Homo sapiens_hsa007500.42539106
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41097297
79Ether lipid metabolism_Homo sapiens_hsa005650.40466185
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39845434
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39698853
82Retinol metabolism_Homo sapiens_hsa008300.38579577
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38450443
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37605381
85Hepatitis B_Homo sapiens_hsa051610.36868813
86Thyroid cancer_Homo sapiens_hsa052160.35845220
87Vitamin digestion and absorption_Homo sapiens_hsa049770.35840049
88Sulfur relay system_Homo sapiens_hsa041220.35437316
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34884084
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34503667
91Chemical carcinogenesis_Homo sapiens_hsa052040.34383010
92Apoptosis_Homo sapiens_hsa042100.32966870
93Carbon metabolism_Homo sapiens_hsa012000.32840167
94Hematopoietic cell lineage_Homo sapiens_hsa046400.32178001
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31396370
96MicroRNAs in cancer_Homo sapiens_hsa052060.31239652
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.31141110
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30857590
99Measles_Homo sapiens_hsa051620.30246321
100Metabolic pathways_Homo sapiens_hsa011000.30042393
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29987468
102Hippo signaling pathway_Homo sapiens_hsa043900.29732033
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28832956
104Arachidonic acid metabolism_Homo sapiens_hsa005900.25857184
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25478591
106beta-Alanine metabolism_Homo sapiens_hsa004100.25172651
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24272763
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23526946
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23293176
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23030209
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.22724836
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.22367081
113Shigellosis_Homo sapiens_hsa051310.22307076
114Fatty acid degradation_Homo sapiens_hsa000710.21081426
115Fat digestion and absorption_Homo sapiens_hsa049750.20168913
116Fatty acid metabolism_Homo sapiens_hsa012120.19881186
117Influenza A_Homo sapiens_hsa051640.19525372
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19317900
119Lysine degradation_Homo sapiens_hsa003100.18437797
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.17199297
121Wnt signaling pathway_Homo sapiens_hsa043100.16933743
122Viral myocarditis_Homo sapiens_hsa054160.16286813
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12916113
124Renin-angiotensin system_Homo sapiens_hsa046140.08889645
125Colorectal cancer_Homo sapiens_hsa052100.08636136
126TGF-beta signaling pathway_Homo sapiens_hsa043500.08586055
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05710161
128Pathways in cancer_Homo sapiens_hsa052000.05504486
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04633923
130Pyruvate metabolism_Homo sapiens_hsa006200.04181982
131Leishmaniasis_Homo sapiens_hsa051400.03912928
132Bladder cancer_Homo sapiens_hsa052190.03570806
133Galactose metabolism_Homo sapiens_hsa000520.03472451
134Pertussis_Homo sapiens_hsa051330.03362916
135HIF-1 signaling pathway_Homo sapiens_hsa040660.02711809
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02256422
137Asthma_Homo sapiens_hsa053100.02115967
138Fructose and mannose metabolism_Homo sapiens_hsa000510.01952545
139Allograft rejection_Homo sapiens_hsa053300.00594591
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00093264
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0268776
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0224196

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