CENPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420]. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.88152150
2attachment of spindle microtubules to kinetochore (GO:0008608)5.84327780
3protein localization to kinetochore (GO:0034501)5.64067242
4CENP-A containing nucleosome assembly (GO:0034080)5.31840472
5protein localization to chromosome, centromeric region (GO:0071459)5.30540941
6kinetochore assembly (GO:0051382)5.24473977
7mitotic metaphase plate congression (GO:0007080)5.10828307
8chromatin remodeling at centromere (GO:0031055)5.05372418
9mitotic sister chromatid segregation (GO:0000070)4.84028821
10meiotic chromosome segregation (GO:0045132)4.82789814
11metaphase plate congression (GO:0051310)4.73606613
12mitotic chromosome condensation (GO:0007076)4.71356104
13telomere maintenance via semi-conservative replication (GO:0032201)4.50591284
14sister chromatid segregation (GO:0000819)4.45817858
15DNA replication-independent nucleosome assembly (GO:0006336)4.45479834
16DNA replication-independent nucleosome organization (GO:0034724)4.45479834
17establishment of chromosome localization (GO:0051303)4.44494055
18replication fork processing (GO:0031297)4.44183434
19regulation of spindle organization (GO:0090224)4.27870773
20DNA strand elongation involved in DNA replication (GO:0006271)4.24680986
21telomere maintenance via recombination (GO:0000722)4.17148600
22histone exchange (GO:0043486)4.14227153
23mitotic recombination (GO:0006312)4.12136476
24DNA strand elongation (GO:0022616)4.06807611
25microtubule depolymerization (GO:0007019)4.04537375
26protein localization to chromosome (GO:0034502)3.93803379
27DNA ligation (GO:0006266)3.90498800
28DNA double-strand break processing (GO:0000729)3.89768830
29regulation of centriole replication (GO:0046599)3.83513972
30spindle checkpoint (GO:0031577)3.81557500
31synapsis (GO:0007129)3.75269545
32DNA replication checkpoint (GO:0000076)3.73569854
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.72079188
34maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.67635981
35telomere maintenance via telomere lengthening (GO:0010833)3.67489950
36chromosome segregation (GO:0007059)3.67277356
37DNA replication initiation (GO:0006270)3.64117768
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62272653
39DNA topological change (GO:0006265)3.61275584
40ribosomal small subunit assembly (GO:0000028)3.60273364
41centriole replication (GO:0007099)3.60145184
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56524062
43DNA deamination (GO:0045006)3.54245633
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53719949
45recombinational repair (GO:0000725)3.48878211
46spindle assembly checkpoint (GO:0071173)3.48208867
47regulation of centrosome cycle (GO:0046605)3.48076618
48double-strand break repair via homologous recombination (GO:0000724)3.45258142
49regulation of chromosome segregation (GO:0051983)3.43483938
50histone-serine phosphorylation (GO:0035404)3.40512506
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.36854256
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36854256
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36854256
54negative regulation of sister chromatid segregation (GO:0033046)3.36854256
55negative regulation of chromosome segregation (GO:0051985)3.34567543
56deoxyribonucleotide biosynthetic process (GO:0009263)3.32894206
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31134311
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.26473357
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26342447
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.24797746
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.24782922
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23141548
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.22363106
64NADH dehydrogenase complex assembly (GO:0010257)3.22363106
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22363106
66mitotic spindle assembly checkpoint (GO:0007094)3.20188812
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14350883
68regulation of mitotic spindle checkpoint (GO:1903504)3.14350883
69regulation of mitotic sister chromatid separation (GO:0010965)3.14310371
70regulation of mitotic sister chromatid segregation (GO:0033047)3.14310371
71regulation of sister chromatid segregation (GO:0033045)3.14310371
72protein K6-linked ubiquitination (GO:0085020)3.09115714
73ATP-dependent chromatin remodeling (GO:0043044)3.08092579
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07489769
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.07489769
76mitotic spindle checkpoint (GO:0071174)3.06944287
77centrosome organization (GO:0051297)3.06711772
78telomere maintenance (GO:0000723)3.06330734
79resolution of meiotic recombination intermediates (GO:0000712)3.05293140
80telomere organization (GO:0032200)3.05115844
81postreplication repair (GO:0006301)3.03111759
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02829396
83maturation of SSU-rRNA (GO:0030490)3.02569315
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.02163125
85regulation of DNA endoreduplication (GO:0032875)3.01697169
86maturation of 5.8S rRNA (GO:0000460)3.01386249
87regulation of mitotic spindle organization (GO:0060236)3.00307607
88protein complex biogenesis (GO:0070271)2.98816639
89mitochondrial respiratory chain complex assembly (GO:0033108)2.98095924
90DNA unwinding involved in DNA replication (GO:0006268)2.97618516
91regulation of centrosome duplication (GO:0010824)2.96462160
92chromosome condensation (GO:0030261)2.96290907
93protein K11-linked deubiquitination (GO:0035871)2.96170558
94reciprocal meiotic recombination (GO:0007131)2.95490482
95reciprocal DNA recombination (GO:0035825)2.95490482
96behavioral response to nicotine (GO:0035095)2.94047295
97pseudouridine synthesis (GO:0001522)2.93910376
98translesion synthesis (GO:0019985)2.93064898
99proteasome assembly (GO:0043248)2.92052558
100mismatch repair (GO:0006298)2.91777003
101DNA replication-dependent nucleosome organization (GO:0034723)2.91546817
102DNA replication-dependent nucleosome assembly (GO:0006335)2.91546817
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90590138
104mitotic nuclear envelope disassembly (GO:0007077)2.89632729
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89625605
106chromatin assembly or disassembly (GO:0006333)2.87047557
107establishment of protein localization to mitochondrial membrane (GO:0090151)2.86828568
108prenylation (GO:0097354)2.85700711
109protein prenylation (GO:0018342)2.85700711
110microtubule organizing center organization (GO:0031023)2.83299571
111* mitotic cell cycle (GO:0000278)2.80264773
112nucleobase biosynthetic process (GO:0046112)2.79913484
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79058060
114ribosomal large subunit biogenesis (GO:0042273)2.79037734
115mitotic sister chromatid cohesion (GO:0007064)2.78920889
116isotype switching (GO:0045190)2.78225987
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73324713
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73324713
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.73324713
120regulation of spindle checkpoint (GO:0090231)2.72055144
121microtubule polymerization or depolymerization (GO:0031109)2.70956894
122DNA packaging (GO:0006323)2.70016365
123DNA synthesis involved in DNA repair (GO:0000731)2.69440797
124DNA catabolic process, exonucleolytic (GO:0000738)2.69287717
125mitotic G2/M transition checkpoint (GO:0044818)2.69231707
126negative regulation of mitosis (GO:0045839)2.68936351
127mitotic nuclear division (GO:0007067)2.67851666
128positive regulation of chromosome segregation (GO:0051984)2.66270138
129transcription-coupled nucleotide-excision repair (GO:0006283)2.66139557
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65702931
131negative regulation of telomere maintenance (GO:0032205)2.65139479
132regulation of sister chromatid cohesion (GO:0007063)2.64155071
133positive regulation of DNA-dependent DNA replication (GO:2000105)2.63723881
134intra-S DNA damage checkpoint (GO:0031573)2.61485307
135regulation of telomere maintenance via telomerase (GO:0032210)2.61183349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89814392
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.16276939
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.95846751
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.84300302
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68336497
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28012274
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.08132677
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.69512944
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66672470
10ZNF274_21170338_ChIP-Seq_K562_Hela2.64968520
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64740097
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.63415986
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60123852
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53145279
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.46432593
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43731520
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33746998
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33590135
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28760620
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28171241
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.26222385
22VDR_22108803_ChIP-Seq_LS180_Human2.24279257
23* AR_21909140_ChIP-Seq_LNCAP_Human2.20751735
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20064679
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17220729
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17116330
27EWS_26573619_Chip-Seq_HEK293_Human2.15080224
28* VDR_23849224_ChIP-Seq_CD4+_Human2.13449166
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12904638
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11908519
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.11078565
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10871209
33FOXP3_21729870_ChIP-Seq_TREG_Human2.01088370
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98676617
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95053865
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88643777
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88513653
38ELK1_19687146_ChIP-ChIP_HELA_Human1.87731423
39XRN2_22483619_ChIP-Seq_HELA_Human1.85969331
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83916249
41* DCP1A_22483619_ChIP-Seq_HELA_Human1.82861693
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81697921
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80916478
44FUS_26573619_Chip-Seq_HEK293_Human1.76957001
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76320384
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74593499
47* TTF2_22483619_ChIP-Seq_HELA_Human1.68974396
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.66437591
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61257631
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.60162432
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54567463
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54369942
53IGF1R_20145208_ChIP-Seq_DFB_Human1.52789528
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49721645
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47613871
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.47240693
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43084943
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42768631
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41819411
60GABP_19822575_ChIP-Seq_HepG2_Human1.40986312
61* CIITA_25753668_ChIP-Seq_RAJI_Human1.40213186
62TAF15_26573619_Chip-Seq_HEK293_Human1.39526405
63* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38380122
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36760273
65SPI1_23547873_ChIP-Seq_NB4_Human1.33702271
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.33546186
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33122812
68MYC_18940864_ChIP-ChIP_HL60_Human1.31801714
69* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31334613
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.30919488
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29238311
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26608449
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25072836
74* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22126317
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20861029
76SCL_19346495_ChIP-Seq_HPC-7_Human1.18843724
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18113812
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17605369
79* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17602817
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16984055
81ER_23166858_ChIP-Seq_MCF-7_Human1.16193494
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14205724
83* YY1_21170310_ChIP-Seq_MESCs_Mouse1.14134289
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13418613
85* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12915455
86P300_19829295_ChIP-Seq_ESCs_Human1.12593417
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12335748
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.11507423
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09027235
90TP53_22573176_ChIP-Seq_HFKS_Human1.08223724
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.05265943
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04354542
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04040468
94MYB_26560356_Chip-Seq_TH2_Human1.01519689
95KDM5A_27292631_Chip-Seq_BREAST_Human0.99883899
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96228000
97GBX2_23144817_ChIP-Seq_PC3_Human0.96192511
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96177127
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94650031
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94383032
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93880127
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91160916
103FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90138420
104FOXA1_25329375_ChIP-Seq_VCAP_Human0.90138420
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90081562
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.89078819
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87787543
108* EZH2_27294783_Chip-Seq_NPCs_Mouse0.86735457
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86712186
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85523066
111IRF1_19129219_ChIP-ChIP_H3396_Human0.85520440
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85342222
113MYB_26560356_Chip-Seq_TH1_Human0.84311723
114* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84232764
115CBP_20019798_ChIP-Seq_JUKART_Human0.83669978
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83669978
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83664406
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83282891
119MYC_22102868_ChIP-Seq_BL_Human0.80805099
120SOX2_19829295_ChIP-Seq_ESCs_Human0.79290960
121NANOG_19829295_ChIP-Seq_ESCs_Human0.79290960
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.79001614
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78174332
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77723156
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76484497
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76462241
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75911967
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75365413
129* PHF8_20622853_ChIP-Seq_HELA_Human0.75242132
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75110847
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74200900
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74174621
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.73303133
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.71743639
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71541870
136VDR_21846776_ChIP-Seq_THP-1_Human0.70434438
137CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69711092
138* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.68648452
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.68196897
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.66977785
141GATA2_22383799_ChIP-Seq_G1ME_Mouse0.66827413
142TFEB_21752829_ChIP-Seq_HELA_Human0.66315785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.28316090
2MP0010094_abnormal_chromosome_stability4.24852410
3MP0008057_abnormal_DNA_replication4.02084582
4MP0003111_abnormal_nucleus_morphology3.95405888
5MP0003077_abnormal_cell_cycle3.59970863
6MP0008058_abnormal_DNA_repair3.38810220
7MP0004957_abnormal_blastocyst_morpholog3.07044023
8MP0008007_abnormal_cellular_replicative2.69410392
9MP0006292_abnormal_olfactory_placode2.35833047
10MP0001835_abnormal_antigen_presentation2.29930645
11MP0002396_abnormal_hematopoietic_system2.26334821
12MP0008932_abnormal_embryonic_tissue2.07745572
13MP0000372_irregular_coat_pigmentation2.03715405
14MP0003763_abnormal_thymus_physiology1.97410891
15MP0005671_abnormal_response_to1.89287290
16MP0002160_abnormal_reproductive_system1.80295207
17MP0008877_abnormal_DNA_methylation1.77576481
18MP0000490_abnormal_crypts_of1.77199406
19MP0000015_abnormal_ear_pigmentation1.75259757
20MP0004808_abnormal_hematopoietic_stem1.72574387
21MP0005174_abnormal_tail_pigmentation1.68276114
22MP0006072_abnormal_retinal_apoptosis1.65789859
23MP0003786_premature_aging1.64252429
24MP0009785_altered_susceptibility_to1.63753691
25MP0002398_abnormal_bone_marrow1.61864630
26MP0002095_abnormal_skin_pigmentation1.60610800
27MP0002234_abnormal_pharynx_morphology1.58093872
28MP0004147_increased_porphyrin_level1.56764279
29MP0003646_muscle_fatigue1.56505916
30MP0002132_abnormal_respiratory_system1.56361166
31MP0009379_abnormal_foot_pigmentation1.54557129
32MP0001188_hyperpigmentation1.51530291
33MP0000427_abnormal_hair_cycle1.51151373
34MP0005551_abnormal_eye_electrophysiolog1.50198739
35MP0009333_abnormal_splenocyte_physiolog1.47970581
36MP0001293_anophthalmia1.47116946
37MP0001800_abnormal_humoral_immune1.46765447
38MP0005645_abnormal_hypothalamus_physiol1.46158550
39MP0001545_abnormal_hematopoietic_system1.45567194
40MP0005397_hematopoietic_system_phenotyp1.45567194
41MP0005253_abnormal_eye_physiology1.42696884
42MP0005389_reproductive_system_phenotype1.40757836
43MP0000685_abnormal_immune_system1.38337097
44MP0003718_maternal_effect1.36685961
45MP0003937_abnormal_limbs/digits/tail_de1.35986197
46MP0002420_abnormal_adaptive_immunity1.35166897
47MP0002452_abnormal_antigen_presenting1.34760200
48MP0000689_abnormal_spleen_morphology1.34702713
49MP0002722_abnormal_immune_system1.34262233
50MP0001819_abnormal_immune_cell1.34084471
51MP0000350_abnormal_cell_proliferation1.34026306
52MP0000566_synostosis1.32243808
53MP0001529_abnormal_vocalization1.32212525
54MP0005075_abnormal_melanosome_morpholog1.31816462
55MP0005025_abnormal_response_to1.31394152
56MP0005171_absent_coat_pigmentation1.30550160
57MP0000703_abnormal_thymus_morphology1.30243314
58MP0002019_abnormal_tumor_incidence1.29747136
59MP0002148_abnormal_hypersensitivity_rea1.28656772
60MP0009697_abnormal_copulation1.28452992
61MP0000716_abnormal_immune_system1.27708579
62MP0003806_abnormal_nucleotide_metabolis1.26530257
63MP0000647_abnormal_sebaceous_gland1.26367017
64MP0008872_abnormal_physiological_respon1.23134801
65MP0002429_abnormal_blood_cell1.23069679
66MP0002723_abnormal_immune_serum1.22853303
67MP0002102_abnormal_ear_morphology1.21799314
68MP0005000_abnormal_immune_tolerance1.21395322
69MP0000631_abnormal_neuroendocrine_gland1.21381221
70MP0000858_altered_metastatic_potential1.20801124
71MP0003195_calcinosis1.20119102
72MP0003436_decreased_susceptibility_to1.20084379
73MP0000313_abnormal_cell_death1.18614621
74MP0002405_respiratory_system_inflammati1.14409561
75MP0002419_abnormal_innate_immunity1.13631242
76MP0002638_abnormal_pupillary_reflex1.12646252
77MP0005387_immune_system_phenotype1.11667591
78MP0001790_abnormal_immune_system1.11667591
79MP0008875_abnormal_xenobiotic_pharmacok1.11367827
80MP0002210_abnormal_sex_determination1.07360233
81MP0002736_abnormal_nociception_after1.06797896
82MP0000465_gastrointestinal_hemorrhage1.06644122
83MP0003698_abnormal_male_reproductive1.06584367
84MP0003941_abnormal_skin_development1.06481831
85MP0001986_abnormal_taste_sensitivity1.06431662
86MP0003315_abnormal_perineum_morphology1.06343823
87MP0003136_yellow_coat_color1.06227778
88MP0009046_muscle_twitch1.05924783
89MP0004381_abnormal_hair_follicle1.04397664
90MP0006035_abnormal_mitochondrial_morpho1.03296088
91MP0001119_abnormal_female_reproductive1.03137676
92MP0002653_abnormal_ependyma_morphology1.02880618
93MP0005408_hypopigmentation1.02823863
94MP0001730_embryonic_growth_arrest1.01868162
95MP0004133_heterotaxia0.99791235
96MP0001853_heart_inflammation0.99763996
97MP0002006_tumorigenesis0.99636785
98MP0003724_increased_susceptibility_to0.95880554
99MP0005187_abnormal_penis_morphology0.95518553
100MP0002166_altered_tumor_susceptibility0.95048806
101MP0010155_abnormal_intestine_physiology0.95033049
102MP0010307_abnormal_tumor_latency0.94677531
103MP0006036_abnormal_mitochondrial_physio0.94592674
104MP0002837_dystrophic_cardiac_calcinosis0.94062643
105MP0002277_abnormal_respiratory_mucosa0.93997572
106MP0003950_abnormal_plasma_membrane0.93892545
107MP0001485_abnormal_pinna_reflex0.93869766
108MP0002938_white_spotting0.93151873
109MP0008789_abnormal_olfactory_epithelium0.92710665
110MP0004043_abnormal_pH_regulation0.92192281
111MP0002163_abnormal_gland_morphology0.90786072
112MP0003656_abnormal_erythrocyte_physiolo0.90247414
113MP0005395_other_phenotype0.89167802
114MP0001286_abnormal_eye_development0.88549048
115MP0004142_abnormal_muscle_tone0.87980512
116MP0001929_abnormal_gametogenesis0.87190400
117MP0001697_abnormal_embryo_size0.86842479
118MP0005464_abnormal_platelet_physiology0.86719137
119MP0005380_embryogenesis_phenotype0.86405744
120MP0001672_abnormal_embryogenesis/_devel0.86405744
121MP0002751_abnormal_autonomic_nervous0.86299601
122MP0002009_preneoplasia0.86143158
123MP0000569_abnormal_digit_pigmentation0.84524960
124MP0006054_spinal_hemorrhage0.84041395
125MP0001145_abnormal_male_reproductive0.83371041
126MP0002928_abnormal_bile_duct0.83259991
127MP0002084_abnormal_developmental_patter0.82139888
128MP0002085_abnormal_embryonic_tissue0.81901688
129MP0005391_vision/eye_phenotype0.81300532
130MP0003123_paternal_imprinting0.78840744
131MP0002080_prenatal_lethality0.78184520
132MP0000358_abnormal_cell_content/0.78006641
133MP0000653_abnormal_sex_gland0.77509657
134MP0003943_abnormal_hepatobiliary_system0.77419985
135MP0005646_abnormal_pituitary_gland0.76532838
136MP0008995_early_reproductive_senescence0.75478615
137MP0001919_abnormal_reproductive_system0.74878513
138MP0005409_darkened_coat_color0.74243784
139MP0009278_abnormal_bone_marrow0.72892062
140MP0001873_stomach_inflammation0.72792819
141MP0003890_abnormal_embryonic-extraembry0.72514998
142MP0003186_abnormal_redox_activity0.72508541
143MP0000383_abnormal_hair_follicle0.71846690
144MP0001324_abnormal_eye_pigmentation0.71331574
145MP0003119_abnormal_digestive_system0.70641124
146MP0005410_abnormal_fertilization0.70522659
147MP0010030_abnormal_orbit_morphology0.70013334
148MP0003787_abnormal_imprinting0.69895751
149MP0004215_abnormal_myocardial_fiber0.69741228
150MP0005084_abnormal_gallbladder_morpholo0.68585405
151MP0001764_abnormal_homeostasis0.68429750
152MP0003448_altered_tumor_morphology0.67671494
153MP0002233_abnormal_nose_morphology0.67427177
154MP0001984_abnormal_olfaction0.66417948
155MP0003755_abnormal_palate_morphology0.65943413
156MP0003121_genomic_imprinting0.65568990

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.30683397
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.23553734
3Reticulocytopenia (HP:0001896)4.02996625
4Birth length less than 3rd percentile (HP:0003561)3.99655157
5Abnormality of chromosome stability (HP:0003220)3.54507336
6Meckel diverticulum (HP:0002245)3.48191857
7Pancreatic cysts (HP:0001737)3.46862119
8Abnormality of the preputium (HP:0100587)3.39833393
9Abnormality of the ileum (HP:0001549)3.33205819
10Aplastic anemia (HP:0001915)3.31660094
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.28810513
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26730159
13Abnormality of alanine metabolism (HP:0010916)3.26730159
14Hyperalaninemia (HP:0003348)3.26730159
15Abnormal lung lobation (HP:0002101)3.25312225
16Abnormality of the renal collecting system (HP:0004742)3.13711929
17Small intestinal stenosis (HP:0012848)3.02682074
18Duodenal stenosis (HP:0100867)3.02682074
19Breast hypoplasia (HP:0003187)2.99747316
20Patellar aplasia (HP:0006443)2.95051240
21Duplicated collecting system (HP:0000081)2.94916256
22Abnormality of midbrain morphology (HP:0002418)2.94160508
23Molar tooth sign on MRI (HP:0002419)2.94160508
24Ectopic kidney (HP:0000086)2.90974280
25Nephroblastoma (Wilms tumor) (HP:0002667)2.90839954
2611 pairs of ribs (HP:0000878)2.89849269
27Clubbing of toes (HP:0100760)2.87180356
28Myelodysplasia (HP:0002863)2.84143413
29Pancreatic fibrosis (HP:0100732)2.81735219
30Embryonal renal neoplasm (HP:0011794)2.78504398
31Aplasia/Hypoplasia of the patella (HP:0006498)2.78180120
32Abnormal number of erythroid precursors (HP:0012131)2.74184867
33Bone marrow hypocellularity (HP:0005528)2.65423073
34Abnormality of cells of the erythroid lineage (HP:0012130)2.55948981
35Pendular nystagmus (HP:0012043)2.53513368
36Abnormality of the renal cortex (HP:0011035)2.53225246
37Abnormality of the duodenum (HP:0002246)2.51022104
38Impulsivity (HP:0100710)2.47194616
39Abnormality of DNA repair (HP:0003254)2.46765895
40Type I transferrin isoform profile (HP:0003642)2.43307359
41Triphalangeal thumb (HP:0001199)2.42508030
42Reduced antithrombin III activity (HP:0001976)2.40601547
43Sloping forehead (HP:0000340)2.39900994
44Acute necrotizing encephalopathy (HP:0006965)2.37740188
45Nephronophthisis (HP:0000090)2.36407002
46Congenital stationary night blindness (HP:0007642)2.35480252
47Supernumerary spleens (HP:0009799)2.32069503
48Pallor (HP:0000980)2.31192777
49Abnormality of the pons (HP:0007361)2.30390880
50Acute encephalopathy (HP:0006846)2.29552022
51Renal cortical cysts (HP:0000803)2.29046811
52Type II lissencephaly (HP:0007260)2.27390491
53Recurrent abscess formation (HP:0002722)2.27360307
54IgM deficiency (HP:0002850)2.27198022
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.26914796
56Increased CSF lactate (HP:0002490)2.24312630
57Hypoplasia of the pons (HP:0012110)2.18742027
58Cleft eyelid (HP:0000625)2.17331018
59Absent thumb (HP:0009777)2.17246110
60Oral leukoplakia (HP:0002745)2.16637353
61Attenuation of retinal blood vessels (HP:0007843)2.13340350
62Absent radius (HP:0003974)2.12781316
63Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12110942
64Progressive macrocephaly (HP:0004481)2.11929205
65Lymphoma (HP:0002665)2.11083045
66Abnormality of pyrimidine metabolism (HP:0004353)2.10926689
67Abnormality of the renal medulla (HP:0100957)2.09512981
68Abnormal mitochondria in muscle tissue (HP:0008316)2.08712016
69Thrombocytosis (HP:0001894)2.07138341
70Astigmatism (HP:0000483)2.05465653
71Medulloblastoma (HP:0002885)2.03817294
72Premature graying of hair (HP:0002216)2.03585172
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.01205624
74Hypoplasia of the fovea (HP:0007750)2.01205624
75Medial flaring of the eyebrow (HP:0010747)2.01134800
76Horseshoe kidney (HP:0000085)2.00955405
77Abnormal spermatogenesis (HP:0008669)2.00386399
78Mitochondrial inheritance (HP:0001427)1.99467992
79Short thumb (HP:0009778)1.99414354
80Tracheoesophageal fistula (HP:0002575)1.95842318
81Abnormality of the carotid arteries (HP:0005344)1.94702057
82Macrocytic anemia (HP:0001972)1.94568372
83Obstructive lung disease (HP:0006536)1.94099678
84Chronic obstructive pulmonary disease (HP:0006510)1.94099678
85Aplasia involving forearm bones (HP:0009822)1.93296765
86Absent forearm bone (HP:0003953)1.93296765
87Carpal bone hypoplasia (HP:0001498)1.92411527
88Panhypogammaglobulinemia (HP:0003139)1.92309118
89Myositis (HP:0100614)1.92305371
90Pancytopenia (HP:0001876)1.90920052
91Lipid accumulation in hepatocytes (HP:0006561)1.90815721
92Cerebellar dysplasia (HP:0007033)1.90785972
93Oligodactyly (hands) (HP:0001180)1.90653781
94Optic nerve coloboma (HP:0000588)1.88911609
95Sclerocornea (HP:0000647)1.88171472
96Elevated erythrocyte sedimentation rate (HP:0003565)1.87986163
97Inability to walk (HP:0002540)1.87572867
98Abnormality of the labia minora (HP:0012880)1.86427536
99Dandy-Walker malformation (HP:0001305)1.86155539
100Increased hepatocellular lipid droplets (HP:0006565)1.85635572
101IgG deficiency (HP:0004315)1.85027730
102Recurrent pneumonia (HP:0006532)1.84736193
103Recurrent bacterial skin infections (HP:0005406)1.84350602
104Increased serum lactate (HP:0002151)1.83997145
105Volvulus (HP:0002580)1.83789634
106Severe combined immunodeficiency (HP:0004430)1.83773552
107Neuroendocrine neoplasm (HP:0100634)1.79735608
108Meningitis (HP:0001287)1.79223257
109Long clavicles (HP:0000890)1.78964499
110Abnormal rod and cone electroretinograms (HP:0008323)1.78684874
111Partial agenesis of the corpus callosum (HP:0001338)1.78649570
112Optic disc pallor (HP:0000543)1.77158386
113Meningioma (HP:0002858)1.77153280
114Colon cancer (HP:0003003)1.76744709
115Recurrent viral infections (HP:0004429)1.75569678
116Pulmonary fibrosis (HP:0002206)1.75289534
117True hermaphroditism (HP:0010459)1.75154453
118Chronic hepatic failure (HP:0100626)1.75111258
119Abnormality of T cell physiology (HP:0011840)1.75048865
120Abnormal number of incisors (HP:0011064)1.74924888
121Large for gestational age (HP:0001520)1.74919767
122Abnormality of the fovea (HP:0000493)1.74886844
123Keratoconjunctivitis sicca (HP:0001097)1.74338592
124Oligohydramnios (HP:0001562)1.74115015
125Methylmalonic acidemia (HP:0002912)1.73976039
126Congenital, generalized hypertrichosis (HP:0004540)1.73764372
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.72787189
128Encephalitis (HP:0002383)1.72620918
129Recurrent fungal infections (HP:0002841)1.72405280
130Abnormal protein glycosylation (HP:0012346)1.72339259
131Abnormal glycosylation (HP:0012345)1.72339259
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72339259
133Abnormal protein N-linked glycosylation (HP:0012347)1.72339259
134Glioma (HP:0009733)1.72125864
135Combined immunodeficiency (HP:0005387)1.71984528
136Aganglionic megacolon (HP:0002251)1.70847173
137Agammaglobulinemia (HP:0004432)1.70835201
138Short middle phalanx of the 5th finger (HP:0004220)1.70303617
139Furrowed tongue (HP:0000221)1.69835346
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.69694033
141Preaxial hand polydactyly (HP:0001177)1.69213261
142Selective tooth agenesis (HP:0001592)1.68992609
143Arteriovenous malformation (HP:0100026)1.68825845
144Pheochromocytoma (HP:0002666)1.68550326
145Type 2 muscle fiber atrophy (HP:0003554)1.68474528
146Flat capital femoral epiphysis (HP:0003370)1.68404511
147Cellular immunodeficiency (HP:0005374)1.68240264
148Pancreatic islet-cell hyperplasia (HP:0004510)1.67663346
149B lymphocytopenia (HP:0010976)1.67436701
150Abnormality of B cell number (HP:0010975)1.67436701
1513-Methylglutaconic aciduria (HP:0003535)1.66502507
152Cerebral edema (HP:0002181)1.66446849
153Progressive inability to walk (HP:0002505)1.66230745
154Leukopenia (HP:0001882)1.65493942
155Embryonal neoplasm (HP:0002898)1.65459845
156Deep philtrum (HP:0002002)1.64754796
157Aplasia/Hypoplasia of the thymus (HP:0010515)1.64521771
158Abnormality of T cells (HP:0002843)1.64196556
159Abnormality of the prostate (HP:0008775)1.63686296
160Petechiae (HP:0000967)1.63643177
161Rough bone trabeculation (HP:0100670)1.62886454
162Eczematoid dermatitis (HP:0000976)1.62331714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.81396786
2WEE13.67725592
3FRK3.56541509
4STK163.19983436
5BRSK23.16401093
6CDC72.92130403
7NEK22.67305875
8SRPK12.59622451
9VRK22.39450417
10CCNB12.34727052
11VRK12.25606579
12BRSK12.13887771
13TLK12.08781551
14BLK2.04690095
15IRAK42.03226778
16PLK11.98038149
17PLK41.97764069
18CLK11.95816292
19MAP4K21.95671951
20STK41.95434270
21TTK1.92208382
22TRIM281.89843682
23ACVR1B1.84785293
24MKNK11.83720277
25EIF2AK11.82289169
26AURKB1.79958111
27TXK1.75006442
28NEK91.72963467
29MKNK21.68931823
30WNK31.66617648
31NME21.65107623
32RPS6KA41.54642904
33STK31.49425741
34MAP4K11.46637931
35EIF2AK21.46352678
36MAP3K141.44894583
37PLK31.44874045
38ZAK1.44636997
39PNCK1.42306326
40TESK21.31870113
41ATR1.28781166
42INSRR1.27608541
43CDK71.27116839
44TEC1.22987284
45STK101.19460006
46PBK1.15881102
47GRK11.12098189
48CHEK21.09222306
49CDK41.05902002
50AURKA1.04616565
51DYRK31.03543719
52TAF11.03137700
53MELK1.01537071
54KIT1.00617411
55PIM10.97451766
56BRD40.92973872
57TNIK0.91388783
58CDK80.89575256
59NEK10.87925251
60WNK40.84257300
61CHEK10.82638223
62ZAP700.80134878
63PASK0.79904556
64MAPK130.79665664
65IKBKB0.77456899
66MAP3K80.77316155
67IKBKE0.76702979
68YES10.76618507
69MAP3K40.75015178
70IRAK30.74296976
71BTK0.73406948
72PLK20.70884182
73MST40.70783870
74STK390.70424629
75STK38L0.69000427
76NLK0.68658324
77NME10.67854903
78ATM0.65883148
79NUAK10.65121919
80EIF2AK30.64139837
81OXSR10.63019484
82CDK30.62894180
83LYN0.62105252
84PDK20.62006364
85RPS6KA50.59920722
86CSNK2A10.58495832
87PRKCI0.57944810
88MATK0.56637171
89PIM20.56115132
90MUSK0.54462252
91CHUK0.54009837
92TSSK60.53982461
93BRAF0.52300430
94CDK60.52113366
95RPS6KB20.51404554
96JAK30.51192125
97BMPR1B0.50088117
98DYRK20.48992353
99CDK10.48852909
100MAP2K70.48693448
101TGFBR10.48669500
102PKN10.48620544
103TAOK20.48216526
104CDK20.47380316
105CSF1R0.47346719
106SYK0.46348885
107MARK30.46307370
108CDK120.44601986
109PINK10.44539933
110TYK20.44370178
111ERBB40.43923225
112TBK10.43647667
113CSNK1G10.40440160
114BCR0.38970589
115CASK0.38867177
116FLT30.38217520
117PRKCG0.37890612
118ADRBK10.37881793
119MAP2K30.36462036
120LATS10.35662264
121MAPKAPK50.34917974
122ADRBK20.34670408
123CDK90.33057406
124CSNK2A20.33003048
125AKT30.31580745
126PAK30.31384732
127UHMK10.30988327
128CSNK1G30.30218682
129PRKCE0.29011212
130MAPK110.28769326
131CSNK1E0.28204009
132ERBB30.27746273
133TRPM70.27618704
134SIK30.26129805
135RPS6KA60.25930413
136CSNK1G20.25536273
137KDR0.25520932
138LCK0.25225788
139CSNK1A1L0.25024390
140RPS6KC10.23303462

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80773137
2Mismatch repair_Homo sapiens_hsa034304.09732918
3Homologous recombination_Homo sapiens_hsa034403.70948504
4Base excision repair_Homo sapiens_hsa034103.42781238
5Fanconi anemia pathway_Homo sapiens_hsa034603.14750013
6Ribosome_Homo sapiens_hsa030102.96073037
7Cell cycle_Homo sapiens_hsa041102.91457204
8RNA polymerase_Homo sapiens_hsa030202.73633563
9Spliceosome_Homo sapiens_hsa030402.69574251
10Non-homologous end-joining_Homo sapiens_hsa034502.61062442
11Nucleotide excision repair_Homo sapiens_hsa034202.60467940
12Pyrimidine metabolism_Homo sapiens_hsa002402.41336688
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38793114
14Proteasome_Homo sapiens_hsa030502.22428050
15RNA transport_Homo sapiens_hsa030132.05892195
16Basal transcription factors_Homo sapiens_hsa030222.04388940
17Oxidative phosphorylation_Homo sapiens_hsa001901.97620370
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90940388
19RNA degradation_Homo sapiens_hsa030181.86304674
20One carbon pool by folate_Homo sapiens_hsa006701.84533518
21p53 signaling pathway_Homo sapiens_hsa041151.73356250
22Parkinsons disease_Homo sapiens_hsa050121.68131955
23Primary immunodeficiency_Homo sapiens_hsa053401.61535854
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60553663
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42210547
26Herpes simplex infection_Homo sapiens_hsa051681.41509356
27Propanoate metabolism_Homo sapiens_hsa006401.40442619
28Phototransduction_Homo sapiens_hsa047441.36653787
29Systemic lupus erythematosus_Homo sapiens_hsa053221.33314399
30Butanoate metabolism_Homo sapiens_hsa006501.32029546
31mRNA surveillance pathway_Homo sapiens_hsa030151.30705127
32Protein export_Homo sapiens_hsa030601.28057227
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.26341449
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25366047
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.25336679
36Purine metabolism_Homo sapiens_hsa002301.25001090
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.20739312
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20656409
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15373312
40Epstein-Barr virus infection_Homo sapiens_hsa051691.07207546
41Caffeine metabolism_Homo sapiens_hsa002321.05174467
42Nitrogen metabolism_Homo sapiens_hsa009101.04728312
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00058426
44Measles_Homo sapiens_hsa051620.99189663
45Sulfur metabolism_Homo sapiens_hsa009200.98795088
46Antigen processing and presentation_Homo sapiens_hsa046120.95385745
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.94163429
48Alzheimers disease_Homo sapiens_hsa050100.91679595
49Tryptophan metabolism_Homo sapiens_hsa003800.89924390
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89425900
51Hematopoietic cell lineage_Homo sapiens_hsa046400.88938519
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88867738
53Steroid biosynthesis_Homo sapiens_hsa001000.87785953
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87162257
55Leishmaniasis_Homo sapiens_hsa051400.86522366
56Graft-versus-host disease_Homo sapiens_hsa053320.84542173
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83570330
58Oocyte meiosis_Homo sapiens_hsa041140.81774413
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80604246
60Folate biosynthesis_Homo sapiens_hsa007900.79403014
61Pyruvate metabolism_Homo sapiens_hsa006200.78991142
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78626006
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77719917
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77151971
65Allograft rejection_Homo sapiens_hsa053300.76611396
66Viral carcinogenesis_Homo sapiens_hsa052030.75753254
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74376052
68Linoleic acid metabolism_Homo sapiens_hsa005910.71638163
69HTLV-I infection_Homo sapiens_hsa051660.71553784
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70047482
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.69290191
72Lysine degradation_Homo sapiens_hsa003100.68251789
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68105656
74Influenza A_Homo sapiens_hsa051640.67855377
75Fatty acid elongation_Homo sapiens_hsa000620.67482245
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67261093
77Apoptosis_Homo sapiens_hsa042100.67064106
78Hepatitis B_Homo sapiens_hsa051610.66028735
79Asthma_Homo sapiens_hsa053100.65986731
80Autoimmune thyroid disease_Homo sapiens_hsa053200.64939394
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63497957
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61458404
83TGF-beta signaling pathway_Homo sapiens_hsa043500.60576343
84Peroxisome_Homo sapiens_hsa041460.60245660
85Legionellosis_Homo sapiens_hsa051340.59941010
86Shigellosis_Homo sapiens_hsa051310.59832219
87Vitamin B6 metabolism_Homo sapiens_hsa007500.59797307
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56643553
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56549759
90Regulation of autophagy_Homo sapiens_hsa041400.54542040
91MicroRNAs in cancer_Homo sapiens_hsa052060.53081305
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53072589
93Olfactory transduction_Homo sapiens_hsa047400.52835325
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52624626
95Small cell lung cancer_Homo sapiens_hsa052220.52519331
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50722843
97Ether lipid metabolism_Homo sapiens_hsa005650.50498852
98Arachidonic acid metabolism_Homo sapiens_hsa005900.48851546
99Glutathione metabolism_Homo sapiens_hsa004800.47676915
100Pertussis_Homo sapiens_hsa051330.45758187
101Cardiac muscle contraction_Homo sapiens_hsa042600.45470948
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.44889930
103Thyroid cancer_Homo sapiens_hsa052160.44469162
104B cell receptor signaling pathway_Homo sapiens_hsa046620.44191293
105Sulfur relay system_Homo sapiens_hsa041220.44141974
106N-Glycan biosynthesis_Homo sapiens_hsa005100.43321456
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.41631731
108Nicotine addiction_Homo sapiens_hsa050330.40876859
109Vitamin digestion and absorption_Homo sapiens_hsa049770.39946019
110Alcoholism_Homo sapiens_hsa050340.39011493
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.38212626
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38117064
113Huntingtons disease_Homo sapiens_hsa050160.37071969
114Malaria_Homo sapiens_hsa051440.36301118
115Taste transduction_Homo sapiens_hsa047420.34329260
116Pentose phosphate pathway_Homo sapiens_hsa000300.33663656
117Hippo signaling pathway_Homo sapiens_hsa043900.32926353
118Osteoclast differentiation_Homo sapiens_hsa043800.31098442
119T cell receptor signaling pathway_Homo sapiens_hsa046600.28731193
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28184066
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27839278
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27619480
123Notch signaling pathway_Homo sapiens_hsa043300.27245098
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25852277
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25697856
126Hedgehog signaling pathway_Homo sapiens_hsa043400.25371651
127Fatty acid metabolism_Homo sapiens_hsa012120.24370814
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23844355
129Retinol metabolism_Homo sapiens_hsa008300.23787740
130Chemical carcinogenesis_Homo sapiens_hsa052040.23464107
131TNF signaling pathway_Homo sapiens_hsa046680.23092585
132Toxoplasmosis_Homo sapiens_hsa051450.21322987
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20955990
134Tuberculosis_Homo sapiens_hsa051520.20347700
135FoxO signaling pathway_Homo sapiens_hsa040680.20258709
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20108939
137Basal cell carcinoma_Homo sapiens_hsa052170.19319877
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18742522
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18717183
140Viral myocarditis_Homo sapiens_hsa054160.18256564
141Colorectal cancer_Homo sapiens_hsa052100.17349615
142Circadian rhythm_Homo sapiens_hsa047100.17100981
143Prostate cancer_Homo sapiens_hsa052150.17097908
144Pathways in cancer_Homo sapiens_hsa052000.16778450
145Selenocompound metabolism_Homo sapiens_hsa004500.15701355
146Metabolic pathways_Homo sapiens_hsa011000.14108102
147beta-Alanine metabolism_Homo sapiens_hsa004100.13918146
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13390591
149Other glycan degradation_Homo sapiens_hsa005110.12661772
150Chemokine signaling pathway_Homo sapiens_hsa040620.12303064

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