CENPM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.35678578
2telomere maintenance via semi-conservative replication (GO:0032201)5.18798666
3ribosomal small subunit assembly (GO:0000028)5.15234257
4DNA strand elongation (GO:0022616)5.08254370
5DNA deamination (GO:0045006)4.93941857
6DNA replication initiation (GO:0006270)4.93085733
7DNA replication checkpoint (GO:0000076)4.70245578
8DNA unwinding involved in DNA replication (GO:0006268)4.67402324
9viral transcription (GO:0019083)4.59820673
10telomere maintenance via recombination (GO:0000722)4.58464155
11mitotic metaphase plate congression (GO:0007080)4.57594607
12protein localization to kinetochore (GO:0034501)4.53599367
13CENP-A containing nucleosome assembly (GO:0034080)4.52043246
14translational termination (GO:0006415)4.51680633
15maturation of SSU-rRNA (GO:0030490)4.47923948
16chromatin remodeling at centromere (GO:0031055)4.46755230
17mitotic recombination (GO:0006312)4.40806819
18ribosomal small subunit biogenesis (GO:0042274)4.33400807
19kinetochore organization (GO:0051383)4.24184205
20telomere maintenance via telomere lengthening (GO:0010833)4.13873947
21protein localization to chromosome, centromeric region (GO:0071459)4.12017725
22nucleobase biosynthetic process (GO:0046112)4.10480470
23translational elongation (GO:0006414)4.10301890
24ribosomal large subunit biogenesis (GO:0042273)4.05367844
25DNA replication-independent nucleosome assembly (GO:0006336)4.04804054
26DNA replication-independent nucleosome organization (GO:0034724)4.04804054
27kinetochore assembly (GO:0051382)4.04498416
28nucleotide-excision repair, DNA gap filling (GO:0006297)4.02559677
29DNA replication-dependent nucleosome assembly (GO:0006335)4.00388135
30DNA replication-dependent nucleosome organization (GO:0034723)4.00388135
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94689354
32metaphase plate congression (GO:0051310)3.94503918
33formation of translation preinitiation complex (GO:0001731)3.92123737
34translational initiation (GO:0006413)3.90700029
35DNA ligation (GO:0006266)3.89372747
36purine nucleobase biosynthetic process (GO:0009113)3.85773069
37mitotic sister chromatid segregation (GO:0000070)3.82569574
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82350795
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.78329517
40negative regulation of ligase activity (GO:0051352)3.78329517
41ribonucleoprotein complex biogenesis (GO:0022613)3.77551298
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76693413
43cotranslational protein targeting to membrane (GO:0006613)3.73285606
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.72262968
45mitotic nuclear envelope disassembly (GO:0007077)3.71641784
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71584108
47protein targeting to ER (GO:0045047)3.71196673
48mitotic chromosome condensation (GO:0007076)3.69286720
49establishment of chromosome localization (GO:0051303)3.67254798
50histone exchange (GO:0043486)3.64034393
51attachment of spindle microtubules to kinetochore (GO:0008608)3.63596128
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.63475017
53proteasome assembly (GO:0043248)3.63041065
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.59776795
55cellular protein complex disassembly (GO:0043624)3.59512530
56regulation of spindle organization (GO:0090224)3.58823895
57spliceosomal snRNP assembly (GO:0000387)3.56405841
58regulation of mitochondrial translation (GO:0070129)3.54126656
59ribosome biogenesis (GO:0042254)3.52400363
60deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.51289621
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.50975793
62viral life cycle (GO:0019058)3.49756482
63protein localization to endoplasmic reticulum (GO:0070972)3.47804764
64folic acid-containing compound biosynthetic process (GO:0009396)3.47722626
65establishment of viral latency (GO:0019043)3.44855716
66deoxyribose phosphate biosynthetic process (GO:0046385)3.44841082
672-deoxyribonucleotide biosynthetic process (GO:0009265)3.44841082
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.44275709
69IMP biosynthetic process (GO:0006188)3.43048552
70chaperone-mediated protein transport (GO:0072321)3.42529337
71rRNA processing (GO:0006364)3.41752223
72replication fork processing (GO:0031297)3.41067272
73sister chromatid segregation (GO:0000819)3.40391642
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40367264
75nuclear envelope disassembly (GO:0051081)3.40045610
76membrane disassembly (GO:0030397)3.40045610
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39269814
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39269814
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39269814
80transcription-coupled nucleotide-excision repair (GO:0006283)3.38127262
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37161948
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37161948
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.37004109
84pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.36082852
85pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.35376682
86signal transduction involved in DNA damage checkpoint (GO:0072422)3.32824808
87signal transduction involved in DNA integrity checkpoint (GO:0072401)3.32824808
88ATP synthesis coupled proton transport (GO:0015986)3.31415663
89energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31415663
90establishment of integrated proviral latency (GO:0075713)3.30506711
91signal transduction involved in cell cycle checkpoint (GO:0072395)3.29138579
92rRNA metabolic process (GO:0016072)3.28825187
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28610174
94regulation of cellular amino acid metabolic process (GO:0006521)3.28308921
95protein complex disassembly (GO:0043241)3.25914917
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25453870
97pseudouridine synthesis (GO:0001522)3.24937387
98deoxyribonucleotide biosynthetic process (GO:0009263)3.22858270
99DNA catabolic process, exonucleolytic (GO:0000738)3.21638598
100DNA double-strand break processing (GO:0000729)3.21401265
101translation (GO:0006412)3.21154968
102cullin deneddylation (GO:0010388)3.17539597
103regulation of nuclear cell cycle DNA replication (GO:0033262)3.16671062
104ribosome assembly (GO:0042255)3.16402099
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15687638
106somatic hypermutation of immunoglobulin genes (GO:0016446)3.15672886
107somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15672886
108spliceosomal complex assembly (GO:0000245)3.15021471
109positive regulation of ligase activity (GO:0051351)3.14609211
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13761870
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13428283
112translesion synthesis (GO:0019985)3.13328421
113cell cycle G1/S phase transition (GO:0044843)3.10314708
114G1/S transition of mitotic cell cycle (GO:0000082)3.10314708
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10214955
116macromolecular complex disassembly (GO:0032984)3.10091721
117regulation of mitotic spindle organization (GO:0060236)3.09432183
118base-excision repair (GO:0006284)3.08546835
119spindle checkpoint (GO:0031577)3.08315652
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07828261
121protein complex biogenesis (GO:0070271)3.07746433
122telomere organization (GO:0032200)3.07737456
123regulation of ubiquitin-protein transferase activity (GO:0051438)3.07630321
124telomere maintenance (GO:0000723)3.07542219
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07020213
126mitochondrial respiratory chain complex assembly (GO:0033108)3.06963246
127rRNA modification (GO:0000154)3.05281377
128chromatin assembly or disassembly (GO:0006333)3.04886640
129postreplication repair (GO:0006301)3.04757610
130negative regulation of chromosome segregation (GO:0051985)3.04059630
131nuclear-transcribed mRNA catabolic process (GO:0000956)3.02136609
132pyrimidine nucleotide catabolic process (GO:0006244)3.01838058
133mismatch repair (GO:0006298)3.01742470
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01069252
135protein K6-linked ubiquitination (GO:0085020)3.01043898
136IMP metabolic process (GO:0046040)3.00869599
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00592374
138negative regulation of sister chromatid segregation (GO:0033046)3.00592374
139negative regulation of mitotic sister chromatid separation (GO:2000816)3.00592374
140negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00592374
141meiotic chromosome segregation (GO:0045132)3.00410553
142chromosome segregation (GO:0007059)3.00242128
143protein targeting to mitochondrion (GO:0006626)2.99672212
144mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98672933
145regulation of chromosome segregation (GO:0051983)2.97664011
146regulation of ligase activity (GO:0051340)2.96703327
147transcription elongation from RNA polymerase III promoter (GO:0006385)2.96134599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human8.49775314
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53503503
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37603602
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83320368
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82578486
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44594536
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40068380
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10351980
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.02980865
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94933286
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87703450
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86071701
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.84021445
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.82701149
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74062229
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56952676
17XRN2_22483619_ChIP-Seq_HELA_Human2.45725145
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30971764
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29657475
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23678464
21VDR_23849224_ChIP-Seq_CD4+_Human2.15854717
22AR_21909140_ChIP-Seq_LNCAP_Human2.13378361
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11879287
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10802097
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08930292
26DCP1A_22483619_ChIP-Seq_HELA_Human2.04311174
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98335445
28* E2F1_21310950_ChIP-Seq_MCF-7_Human1.97832222
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.93788273
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92914087
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92544464
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89547160
33TTF2_22483619_ChIP-Seq_HELA_Human1.87563857
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85821012
35GABP_19822575_ChIP-Seq_HepG2_Human1.83554408
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83513247
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76723550
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75909690
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71463705
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.66792147
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59510717
42CIITA_25753668_ChIP-Seq_RAJI_Human1.57791610
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55127248
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54282918
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52704996
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50465411
47ELK1_19687146_ChIP-ChIP_HELA_Human1.48445807
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46716051
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45610178
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42220350
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.41748264
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.40618318
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39266579
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39238143
55KDM5A_27292631_Chip-Seq_BREAST_Human1.37114186
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34953387
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32888684
58* MYC_22102868_ChIP-Seq_BL_Human1.30243875
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29939725
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28313930
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27974926
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23847589
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23723988
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21870536
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20968150
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20118337
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19357484
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17924040
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17119196
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14735451
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13813149
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11837389
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09379242
74MYC_18940864_ChIP-ChIP_HL60_Human1.05656710
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05474541
76VDR_21846776_ChIP-Seq_THP-1_Human1.04538194
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01949687
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00910265
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00066915
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99628088
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99588741
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98180144
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97145073
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96900898
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95933206
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.95155624
87* TFEB_21752829_ChIP-Seq_HELA_Human0.94494181
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.93936565
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91496482
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89781782
91IRF1_19129219_ChIP-ChIP_H3396_Human0.88692276
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88682293
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.87387080
94* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87354283
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86488535
96* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85874845
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85273679
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83631907
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83449155
100SPI1_23547873_ChIP-Seq_NB4_Human0.83164850
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82345127
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81575000
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81131493
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81075577
105NANOG_21062744_ChIP-ChIP_HESCs_Human0.80899178
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.80269399
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79867873
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.79517214
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76424628
110* FOXP1_21924763_ChIP-Seq_HESCs_Human0.75106555
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72842446
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70627661
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67313030
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.65377580
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.64142746
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62049469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.02971470
2MP0010094_abnormal_chromosome_stability5.19377862
3MP0003111_abnormal_nucleus_morphology5.03031388
4MP0004957_abnormal_blastocyst_morpholog4.79675536
5MP0003077_abnormal_cell_cycle4.40190919
6MP0008057_abnormal_DNA_replication4.08966607
7MP0008058_abnormal_DNA_repair3.50663287
8MP0008007_abnormal_cellular_replicative3.05621233
9MP0008932_abnormal_embryonic_tissue2.97136157
10MP0001730_embryonic_growth_arrest2.34430157
11MP0000350_abnormal_cell_proliferation2.31959672
12MP0002396_abnormal_hematopoietic_system2.30862563
13MP0003123_paternal_imprinting2.23940766
14MP0003806_abnormal_nucleotide_metabolis2.15164713
15MP0009697_abnormal_copulation2.13844232
16MP0000372_irregular_coat_pigmentation2.09036937
17MP0003786_premature_aging2.07369553
18MP0003718_maternal_effect2.03998043
19MP0009379_abnormal_foot_pigmentation2.02032632
20MP0002163_abnormal_gland_morphology2.00254110
21MP0000490_abnormal_crypts_of1.84143130
22MP0001346_abnormal_lacrimal_gland1.71144965
23MP0001697_abnormal_embryo_size1.69275930
24MP0008877_abnormal_DNA_methylation1.68975111
25MP0010307_abnormal_tumor_latency1.63943448
26MP0005380_embryogenesis_phenotype1.62661040
27MP0001672_abnormal_embryogenesis/_devel1.62661040
28MP0000313_abnormal_cell_death1.58547623
29MP0002080_prenatal_lethality1.57561639
30MP0010352_gastrointestinal_tract_polyps1.55822987
31MP0002019_abnormal_tumor_incidence1.52923758
32MP0002085_abnormal_embryonic_tissue1.46162672
33MP0003984_embryonic_growth_retardation1.41247264
34MP0003186_abnormal_redox_activity1.40420144
35MP0006292_abnormal_olfactory_placode1.39150803
36MP0002088_abnormal_embryonic_growth/wei1.37973434
37MP0009333_abnormal_splenocyte_physiolog1.33799489
38MP0004808_abnormal_hematopoietic_stem1.31197500
39MP0002210_abnormal_sex_determination1.28883178
40MP0003567_abnormal_fetal_cardiomyocyte1.24414254
41MP0010030_abnormal_orbit_morphology1.23692067
42MP0005397_hematopoietic_system_phenotyp1.22353662
43MP0001545_abnormal_hematopoietic_system1.22353662
44MP0002086_abnormal_extraembryonic_tissu1.22094378
45MP0002234_abnormal_pharynx_morphology1.18183276
46MP0002084_abnormal_developmental_patter1.17284412
47MP0004133_heterotaxia1.14784540
48MP0001145_abnormal_male_reproductive1.14638977
49MP0004197_abnormal_fetal_growth/weight/1.14330053
50MP0003315_abnormal_perineum_morphology1.13848733
51MP0000015_abnormal_ear_pigmentation1.13277199
52MP0003941_abnormal_skin_development1.10336372
53MP0008789_abnormal_olfactory_epithelium1.08992849
54MP0001293_anophthalmia1.07241417
55MP0000703_abnormal_thymus_morphology1.05214478
56MP0002160_abnormal_reproductive_system1.03690663
57MP0005408_hypopigmentation1.02350833
58MP0009053_abnormal_anal_canal1.01862021
59MP0002132_abnormal_respiratory_system1.00541308
60MP0006036_abnormal_mitochondrial_physio1.00357611
61MP0003763_abnormal_thymus_physiology0.99566662
62MP0001929_abnormal_gametogenesis0.98410543
63MP0002722_abnormal_immune_system0.98220079
64MP0000653_abnormal_sex_gland0.98024271
65MP0002736_abnormal_nociception_after0.97206503
66MP0003119_abnormal_digestive_system0.96734250
67MP0001529_abnormal_vocalization0.96324981
68MP0002398_abnormal_bone_marrow0.95828577
69MP0000689_abnormal_spleen_morphology0.93771032
70MP0000358_abnormal_cell_content/0.93287476
71MP0001119_abnormal_female_reproductive0.92094968
72MP0000858_altered_metastatic_potential0.91268953
73MP0002102_abnormal_ear_morphology0.90242724
74MP0005389_reproductive_system_phenotype0.88673629
75MP0008995_early_reproductive_senescence0.87655928
76MP0005379_endocrine/exocrine_gland_phen0.87211165
77MP0002653_abnormal_ependyma_morphology0.86073002
78MP0006054_spinal_hemorrhage0.83034394
79MP0003121_genomic_imprinting0.81611682
80MP0006072_abnormal_retinal_apoptosis0.80847389
81MP0003698_abnormal_male_reproductive0.79262355
82MP0002429_abnormal_blood_cell0.78955943
83MP0005076_abnormal_cell_differentiation0.77802675
84MP0002111_abnormal_tail_morphology0.76921509
85MP0001919_abnormal_reproductive_system0.75495106
86MP0001853_heart_inflammation0.73460456
87MP0009672_abnormal_birth_weight0.72082878
88MP0005384_cellular_phenotype0.71787099
89MP0003890_abnormal_embryonic-extraembry0.70630957
90MP0006035_abnormal_mitochondrial_morpho0.69683315
91MP0005084_abnormal_gallbladder_morpholo0.69071138
92MP0005645_abnormal_hypothalamus_physiol0.68284138
93MP0005266_abnormal_metabolism0.67708184
94MP0002095_abnormal_skin_pigmentation0.65704269
95MP0005075_abnormal_melanosome_morpholog0.65349618
96MP0003221_abnormal_cardiomyocyte_apopto0.64696119
97MP0005621_abnormal_cell_physiology0.64340085
98MP0003646_muscle_fatigue0.63682367
99MP0005394_taste/olfaction_phenotype0.63535372
100MP0005499_abnormal_olfactory_system0.63535372
101MP0003656_abnormal_erythrocyte_physiolo0.61969755
102MP0004147_increased_porphyrin_level0.61553787
103MP0005023_abnormal_wound_healing0.60904019
104MP0000716_abnormal_immune_system0.60581213
105MP0001286_abnormal_eye_development0.60400413
106MP0000477_abnormal_intestine_morphology0.59997669
107MP0005083_abnormal_biliary_tract0.58668041
108MP0003136_yellow_coat_color0.58325288
109MP0001661_extended_life_span0.56936088
110MP0005377_hearing/vestibular/ear_phenot0.55703819
111MP0003878_abnormal_ear_physiology0.55703819
112MP0005670_abnormal_white_adipose0.55443140
113MP0002751_abnormal_autonomic_nervous0.55207571
114MP0001915_intracranial_hemorrhage0.55183595
115MP0005501_abnormal_skin_physiology0.54167918
116MP0001186_pigmentation_phenotype0.53925747
117MP0001881_abnormal_mammary_gland0.52982224
118MP0009278_abnormal_bone_marrow0.52901435
119MP0003699_abnormal_female_reproductive0.52783105
120MP0000049_abnormal_middle_ear0.52608566
121MP0002938_white_spotting0.51955692
122MP0005174_abnormal_tail_pigmentation0.51136150
123MP0002177_abnormal_outer_ear0.50355286
124MP0002092_abnormal_eye_morphology0.46590441
125MP0003937_abnormal_limbs/digits/tail_de0.45816333
126MP0005395_other_phenotype0.45730980
127MP0001764_abnormal_homeostasis0.45549635
128MP0002075_abnormal_coat/hair_pigmentati0.44304538
129MP0002161_abnormal_fertility/fecundity0.43715771

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.38265726
2Birth length less than 3rd percentile (HP:0003561)5.31391366
3Abnormality of cells of the erythroid lineage (HP:0012130)4.80598608
4Abnormal number of erythroid precursors (HP:0012131)4.70794909
5Breast hypoplasia (HP:0003187)4.57041431
6Acute necrotizing encephalopathy (HP:0006965)4.31653556
7Oral leukoplakia (HP:0002745)4.29006680
8Abnormal mitochondria in muscle tissue (HP:0008316)4.15256860
9Acute encephalopathy (HP:0006846)4.04021536
10Chromsome breakage (HP:0040012)3.96323398
11Mitochondrial inheritance (HP:0001427)3.92990720
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84929191
13Colon cancer (HP:0003003)3.81596397
14Patellar aplasia (HP:0006443)3.60690515
15Macrocytic anemia (HP:0001972)3.56134847
16Aplastic anemia (HP:0001915)3.45255026
17Aplasia/Hypoplasia of the patella (HP:0006498)3.41819412
18Progressive macrocephaly (HP:0004481)3.39389960
19Meckel diverticulum (HP:0002245)3.38534018
20Hepatic necrosis (HP:0002605)3.31884482
21Rough bone trabeculation (HP:0100670)3.31784117
22Pallor (HP:0000980)3.31628200
23Abnormality of the preputium (HP:0100587)3.30377796
24Selective tooth agenesis (HP:0001592)3.28289831
25Abnormality of the ileum (HP:0001549)3.24286609
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20538448
27Abnormality of the anterior horn cell (HP:0006802)3.15086580
28Degeneration of anterior horn cells (HP:0002398)3.15086580
29Carpal bone hypoplasia (HP:0001498)3.12934401
30Abnormality of chromosome stability (HP:0003220)3.10648233
31Absent thumb (HP:0009777)3.09428934
32Cerebral edema (HP:0002181)3.02361678
33Microvesicular hepatic steatosis (HP:0001414)2.90557367
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.90191001
35Lipid accumulation in hepatocytes (HP:0006561)2.85351840
36Absent radius (HP:0003974)2.81769318
37Cerebral hypomyelination (HP:0006808)2.76326201
38Medulloblastoma (HP:0002885)2.74686174
39Microretrognathia (HP:0000308)2.72382151
40Premature graying of hair (HP:0002216)2.72094443
41Lactic acidosis (HP:0003128)2.70784813
42Small intestinal stenosis (HP:0012848)2.68491701
43Duodenal stenosis (HP:0100867)2.68491701
44Impulsivity (HP:0100710)2.65125851
45Myelodysplasia (HP:0002863)2.63520007
46Aplasia involving forearm bones (HP:0009822)2.62143325
47Absent forearm bone (HP:0003953)2.62143325
48Bone marrow hypocellularity (HP:0005528)2.60982364
49Horseshoe kidney (HP:0000085)2.60625070
5011 pairs of ribs (HP:0000878)2.60433722
51Trismus (HP:0000211)2.57747313
52Triphalangeal thumb (HP:0001199)2.53904037
53Neoplasm of the pancreas (HP:0002894)2.53499324
54Increased intramyocellular lipid droplets (HP:0012240)2.51355957
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47727407
56Abnormal protein N-linked glycosylation (HP:0012347)2.47727407
57Abnormal protein glycosylation (HP:0012346)2.47727407
58Abnormal glycosylation (HP:0012345)2.47727407
59Abnormal number of incisors (HP:0011064)2.44519184
60Ependymoma (HP:0002888)2.42832907
61Abnormal lung lobation (HP:0002101)2.42177553
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40983921
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40983921
64Respiratory failure (HP:0002878)2.40324729
65Rhabdomyosarcoma (HP:0002859)2.39696580
66Thrombocytosis (HP:0001894)2.38007614
67Abnormal trabecular bone morphology (HP:0100671)2.37516780
68Abnormality of pyrimidine metabolism (HP:0004353)2.37008694
69Tracheoesophageal fistula (HP:0002575)2.36033597
70Supernumerary spleens (HP:0009799)2.35784762
71Multiple enchondromatosis (HP:0005701)2.35585639
72Agnosia (HP:0010524)2.33946340
73Exercise intolerance (HP:0003546)2.33434285
74Renal Fanconi syndrome (HP:0001994)2.33082354
75Methylmalonic aciduria (HP:0012120)2.32078390
76Cleft eyelid (HP:0000625)2.30950660
77Secondary amenorrhea (HP:0000869)2.29579335
78Sloping forehead (HP:0000340)2.28450015
79Reduced antithrombin III activity (HP:0001976)2.28093175
80Pancytopenia (HP:0001876)2.27079814
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25862167
82Premature ovarian failure (HP:0008209)2.25393094
83Duplicated collecting system (HP:0000081)2.25307021
84Abnormality of reticulocytes (HP:0004312)2.19539406
85Abnormality of DNA repair (HP:0003254)2.18972830
86Cellular immunodeficiency (HP:0005374)2.18839019
87Abnormality of the duodenum (HP:0002246)2.18612145
88Atresia of the external auditory canal (HP:0000413)2.16224881
89Progressive microcephaly (HP:0000253)2.15898534
90Increased serum lactate (HP:0002151)2.14921013
91Increased muscle lipid content (HP:0009058)2.12903839
92Abnormality of the labia minora (HP:0012880)2.11722399
93Dicarboxylic aciduria (HP:0003215)2.09341399
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09341399
95Basal cell carcinoma (HP:0002671)2.08817924
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07885109
97Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04528596
98Ectopic kidney (HP:0000086)2.01537350
99Abnormality of glycolysis (HP:0004366)2.01169001
100Short thumb (HP:0009778)1.97702866
101Squamous cell carcinoma (HP:0002860)1.97141093
102IgM deficiency (HP:0002850)1.97120859
103Leukodystrophy (HP:0002415)1.96764211
104Hypoplasia of the radius (HP:0002984)1.93218636
105Abnormality of the renal collecting system (HP:0004742)1.92847649
106Hyperglycinemia (HP:0002154)1.92789343
107Slender long bone (HP:0003100)1.92020138
108Abnormality of the carotid arteries (HP:0005344)1.91482969
109Exertional dyspnea (HP:0002875)1.90554825
110Clubbing of toes (HP:0100760)1.90466864
111Neoplasm of the colon (HP:0100273)1.90204000
112Sparse eyelashes (HP:0000653)1.89172835
113Lethargy (HP:0001254)1.87599822
114B lymphocytopenia (HP:0010976)1.87357581
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86900977
116Abnormality of the heme biosynthetic pathway (HP:0010472)1.86637479
117Increased hepatocellular lipid droplets (HP:0006565)1.86136498
118Type I transferrin isoform profile (HP:0003642)1.85224230
119Hepatocellular necrosis (HP:0001404)1.85066270
120Cafe-au-lait spot (HP:0000957)1.83914194
121Testicular atrophy (HP:0000029)1.82994270
122Lymphoma (HP:0002665)1.82316929
123Progressive muscle weakness (HP:0003323)1.82038821
124Optic disc pallor (HP:0000543)1.81069912
125Methylmalonic acidemia (HP:0002912)1.79861700
126Facial cleft (HP:0002006)1.79827460
127Abnormality of abdominal situs (HP:0011620)1.79664597
128Abdominal situs inversus (HP:0003363)1.79664597
129Missing ribs (HP:0000921)1.79656632
130Increased serum pyruvate (HP:0003542)1.78814670
131Irregular epiphyses (HP:0010582)1.77625424
132Opisthotonus (HP:0002179)1.76972835
133Poor head control (HP:0002421)1.75161379
134Megaloblastic anemia (HP:0001889)1.74706235
135Increased CSF lactate (HP:0002490)1.73588622
136Pendular nystagmus (HP:0012043)1.73399778
1373-Methylglutaconic aciduria (HP:0003535)1.71238699
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.70614840
139Glossoptosis (HP:0000162)1.69331611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.39121525
2VRK25.05290135
3WEE14.47772675
4CDC73.96723149
5EIF2AK13.53310194
6TLK12.81287768
7NME22.79017026
8NEK22.76083278
9SRPK12.43984917
10TTK2.42383561
11NEK12.29313230
12TESK22.25250145
13PLK42.19053418
14PLK12.16642801
15BRSK22.12111072
16ACVR1B2.09811508
17VRK12.09573417
18TAF12.02694672
19STK161.94406512
20CCNB11.90953957
21CDK71.85073491
22NUAK11.82992129
23AURKB1.81203821
24EIF2AK31.75460185
25BRSK11.67846837
26AURKA1.58669820
27ATR1.55333895
28SMG11.55261031
29DYRK31.53176327
30CHEK21.49300012
31TSSK61.48425512
32RPS6KB21.46689162
33RPS6KA41.45776287
34MKNK11.43258400
35MST41.41463587
36PLK31.33348401
37STK41.31804901
38MAP3K81.31651739
39TRIM281.26921241
40PIM21.20456357
41MKNK21.19807654
42CDK41.19648310
43PASK1.18183067
44MAP4K21.13005684
45SCYL21.08853377
46CDK81.05777255
47PAK41.02691238
48BRAF1.01352503
49STK101.00709210
50CHEK11.00506081
51MAP3K100.99323609
52PDK20.95313287
53CSNK1G30.92009594
54ZAK0.91607001
55PBK0.85441411
56TESK10.83125879
57MAP3K110.82938767
58PIM10.81437370
59MAPKAPK30.80959703
60BMPR1B0.80912730
61BCKDK0.80149680
62EIF2AK20.80018771
63EPHA20.79399654
64CDK20.76848546
65KDR0.75891369
66MAP4K10.75529676
67ATM0.75499593
68CLK10.74436369
69PAK10.74025594
70CSNK2A10.72683507
71CSNK1G10.70608931
72CSNK1A1L0.68880908
73CSNK2A20.68729637
74TGFBR10.67708184
75INSRR0.67541396
76MELK0.64692674
77CDK120.64573803
78TXK0.64023262
79LRRK20.63947322
80FLT30.63813142
81EEF2K0.62928562
82CDK190.61414176
83PRKCI0.61137074
84BCR0.56810462
85CSNK1G20.56360986
86CDK10.55431536
87DAPK30.55388611
88NME10.53751141
89WNK30.51970606
90RPS6KA50.50480606
91ARAF0.47601609
92TAOK20.46631742
93CDK60.44477938
94MAPKAPK50.44436014
95MUSK0.42994967
96BLK0.38912652
97DYRK20.38497626
98LATS20.36704298
99FRK0.36171461
100ABL20.36100532
101MAP2K30.35258633
102MAPK110.33975637
103IRAK30.32220601
104CDK180.30873347
105ILK0.30648104
106STK38L0.29916510
107CDK150.29601713
108PKN20.29585241
109BTK0.29396342
110AKT20.29376042
111ALK0.27483797
112TEC0.27443252
113CDK140.26875600
114OXSR10.26765305
115PRKDC0.26225869
116DAPK10.26157877
117PKN10.25629851
118MARK30.25489280
119LIMK10.24933507
120CDK11A0.24917659
121GRK60.24370289
122YES10.23672283
123NEK90.23255555
124PLK20.23022705
125IRAK40.21625815
126RPS6KL10.20772877
127RPS6KC10.20772877
128GRK50.20712082
129LYN0.18814853
130AKT30.18563415
131CSNK1E0.18315848

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.47668482
2Mismatch repair_Homo sapiens_hsa034304.61387055
3Ribosome_Homo sapiens_hsa030104.25037141
4Homologous recombination_Homo sapiens_hsa034403.40162813
5Base excision repair_Homo sapiens_hsa034103.37208278
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27595056
7Spliceosome_Homo sapiens_hsa030403.22096950
8Proteasome_Homo sapiens_hsa030503.21525421
9RNA polymerase_Homo sapiens_hsa030203.20798587
10Nucleotide excision repair_Homo sapiens_hsa034203.01962238
11RNA transport_Homo sapiens_hsa030132.79145695
12One carbon pool by folate_Homo sapiens_hsa006702.74144749
13Pyrimidine metabolism_Homo sapiens_hsa002402.69413140
14Cell cycle_Homo sapiens_hsa041102.66031298
15Fanconi anemia pathway_Homo sapiens_hsa034602.41825836
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05651573
17Non-homologous end-joining_Homo sapiens_hsa034502.01134311
18Basal transcription factors_Homo sapiens_hsa030221.77501663
19RNA degradation_Homo sapiens_hsa030181.73166924
20p53 signaling pathway_Homo sapiens_hsa041151.57667287
21mRNA surveillance pathway_Homo sapiens_hsa030151.46796584
22Purine metabolism_Homo sapiens_hsa002301.33720251
23Folate biosynthesis_Homo sapiens_hsa007901.21795985
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21241446
25Fatty acid elongation_Homo sapiens_hsa000621.20788875
26Systemic lupus erythematosus_Homo sapiens_hsa053221.09543880
27Pyruvate metabolism_Homo sapiens_hsa006201.03808755
28Propanoate metabolism_Homo sapiens_hsa006401.03522073
29Epstein-Barr virus infection_Homo sapiens_hsa051691.03083501
30Sulfur relay system_Homo sapiens_hsa041221.02127298
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98166140
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98057959
33Huntingtons disease_Homo sapiens_hsa050160.97278026
34Parkinsons disease_Homo sapiens_hsa050120.95581117
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.91543565
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.91485155
37Pentose phosphate pathway_Homo sapiens_hsa000300.90545622
38Oocyte meiosis_Homo sapiens_hsa041140.89045115
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.87546952
40Biosynthesis of amino acids_Homo sapiens_hsa012300.85503098
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85137462
42Protein export_Homo sapiens_hsa030600.83371385
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79356278
44Selenocompound metabolism_Homo sapiens_hsa004500.75753353
45Herpes simplex infection_Homo sapiens_hsa051680.75392326
46Oxidative phosphorylation_Homo sapiens_hsa001900.75266602
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74767296
48Vitamin B6 metabolism_Homo sapiens_hsa007500.73663182
49Glutathione metabolism_Homo sapiens_hsa004800.71772558
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70188174
51Viral carcinogenesis_Homo sapiens_hsa052030.67344686
52Antigen processing and presentation_Homo sapiens_hsa046120.65328724
53HTLV-I infection_Homo sapiens_hsa051660.60467167
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58141508
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55532901
56Carbon metabolism_Homo sapiens_hsa012000.53400871
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52570448
58Steroid biosynthesis_Homo sapiens_hsa001000.51152530
59Cardiac muscle contraction_Homo sapiens_hsa042600.50280891
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50026677
61Butanoate metabolism_Homo sapiens_hsa006500.45928770
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45516585
63Thyroid cancer_Homo sapiens_hsa052160.44829877
64Primary immunodeficiency_Homo sapiens_hsa053400.44341953
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43225416
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43057855
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41462429
68Peroxisome_Homo sapiens_hsa041460.41298322
69Fatty acid metabolism_Homo sapiens_hsa012120.41056349
70Small cell lung cancer_Homo sapiens_hsa052220.37891919
71Legionellosis_Homo sapiens_hsa051340.37789586
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37176538
73Bladder cancer_Homo sapiens_hsa052190.34542982
74MicroRNAs in cancer_Homo sapiens_hsa052060.34062455
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33988105
76Metabolic pathways_Homo sapiens_hsa011000.32790235
77Fructose and mannose metabolism_Homo sapiens_hsa000510.32587664
78Sulfur metabolism_Homo sapiens_hsa009200.32484746
79Alzheimers disease_Homo sapiens_hsa050100.31197405
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30531219
81Apoptosis_Homo sapiens_hsa042100.30235891
82Alcoholism_Homo sapiens_hsa050340.29196173
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28867885
84N-Glycan biosynthesis_Homo sapiens_hsa005100.28346055
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27245863
86Tryptophan metabolism_Homo sapiens_hsa003800.26536632
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24062150
88Galactose metabolism_Homo sapiens_hsa000520.23279766
89Fatty acid degradation_Homo sapiens_hsa000710.23051759
90Hepatitis B_Homo sapiens_hsa051610.21368964
91Phototransduction_Homo sapiens_hsa047440.19949786
92Lysine degradation_Homo sapiens_hsa003100.19297937
93Basal cell carcinoma_Homo sapiens_hsa052170.19019030
94Tyrosine metabolism_Homo sapiens_hsa003500.18547776
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18263760
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18185376
97Shigellosis_Homo sapiens_hsa051310.17787818
98Measles_Homo sapiens_hsa051620.17454765
99beta-Alanine metabolism_Homo sapiens_hsa004100.17245797
100TGF-beta signaling pathway_Homo sapiens_hsa043500.16242153
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14639728
102Hippo signaling pathway_Homo sapiens_hsa043900.14098952
103Colorectal cancer_Homo sapiens_hsa052100.13953963
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12836572
105Arginine and proline metabolism_Homo sapiens_hsa003300.12609748
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12057144
107Arachidonic acid metabolism_Homo sapiens_hsa005900.10954262
108Notch signaling pathway_Homo sapiens_hsa043300.09606757
109HIF-1 signaling pathway_Homo sapiens_hsa040660.09548134
110Phenylalanine metabolism_Homo sapiens_hsa003600.09548025
111Renin-angiotensin system_Homo sapiens_hsa046140.09354973
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08673770
113Influenza A_Homo sapiens_hsa051640.07352927
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.07238004
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06953327
116Pathways in cancer_Homo sapiens_hsa052000.06435902
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06318728
118Chronic myeloid leukemia_Homo sapiens_hsa052200.05797536
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.05110185
120Acute myeloid leukemia_Homo sapiens_hsa052210.04245909
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04234964
122Chemical carcinogenesis_Homo sapiens_hsa052040.03989543
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03802398
124Hematopoietic cell lineage_Homo sapiens_hsa046400.03351170
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03284136
126Vitamin digestion and absorption_Homo sapiens_hsa049770.03011760
127Autoimmune thyroid disease_Homo sapiens_hsa053200.02968802
128Hedgehog signaling pathway_Homo sapiens_hsa043400.01357460

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