CENPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.12691060
2telomere maintenance via semi-conservative replication (GO:0032201)5.05492719
3DNA replication initiation (GO:0006270)5.02073645
4DNA unwinding involved in DNA replication (GO:0006268)4.86214168
5DNA strand elongation (GO:0022616)4.85139749
6nuclear pore complex assembly (GO:0051292)4.84310847
7* CENP-A containing nucleosome assembly (GO:0034080)4.75982550
8* chromatin remodeling at centromere (GO:0031055)4.64474094
9protein localization to kinetochore (GO:0034501)4.59966444
10DNA replication checkpoint (GO:0000076)4.56869233
11telomere maintenance via recombination (GO:0000722)4.56565718
12kinetochore organization (GO:0051383)4.51241664
13mitotic recombination (GO:0006312)4.40697689
14nuclear pore organization (GO:0006999)4.35975896
15mitotic metaphase plate congression (GO:0007080)4.32401920
16regulation of sister chromatid cohesion (GO:0007063)4.32134255
17* DNA replication-independent nucleosome assembly (GO:0006336)4.25223473
18* DNA replication-independent nucleosome organization (GO:0034724)4.25223473
19mitotic chromosome condensation (GO:0007076)4.21035494
20protein localization to chromosome, centromeric region (GO:0071459)4.18637377
21chromosome condensation (GO:0030261)4.16679042
22ribosomal small subunit assembly (GO:0000028)4.16008887
23kinetochore assembly (GO:0051382)4.15145238
24maturation of SSU-rRNA (GO:0030490)4.07012766
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.06163450
26telomere maintenance via telomere lengthening (GO:0010833)4.03261397
27DNA topological change (GO:0006265)4.03037107
28nucleotide-excision repair, DNA gap filling (GO:0006297)4.00105517
29* histone exchange (GO:0043486)3.99951713
30metaphase plate congression (GO:0051310)3.95132622
31attachment of spindle microtubules to kinetochore (GO:0008608)3.93870623
32regulation of centriole replication (GO:0046599)3.88725449
33mitotic sister chromatid segregation (GO:0000070)3.88015129
34DNA deamination (GO:0045006)3.84390565
35viral transcription (GO:0019083)3.83610957
36DNA replication-dependent nucleosome assembly (GO:0006335)3.81717989
37DNA replication-dependent nucleosome organization (GO:0034723)3.81717989
38translational termination (GO:0006415)3.79228697
39establishment of chromosome localization (GO:0051303)3.72048279
40regulation of mitotic spindle organization (GO:0060236)3.68204998
41pore complex assembly (GO:0046931)3.65983607
42mitotic nuclear envelope disassembly (GO:0007077)3.64465472
43DNA ligation (GO:0006266)3.62972692
44ribosomal small subunit biogenesis (GO:0042274)3.58441096
45DNA packaging (GO:0006323)3.56844205
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51409912
47heterochromatin organization (GO:0070828)3.45555197
48sister chromatid segregation (GO:0000819)3.45439583
49meiotic chromosome segregation (GO:0045132)3.40300350
50nucleobase biosynthetic process (GO:0046112)3.39250592
51translational elongation (GO:0006414)3.38434997
52ribosomal large subunit biogenesis (GO:0042273)3.34283174
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.33845598
54membrane disassembly (GO:0030397)3.31815991
55nuclear envelope disassembly (GO:0051081)3.31815991
56negative regulation of chromosome segregation (GO:0051985)3.31602850
57translational initiation (GO:0006413)3.31480449
58establishment of integrated proviral latency (GO:0075713)3.30413725
59formation of translation preinitiation complex (GO:0001731)3.29687084
60microtubule depolymerization (GO:0007019)3.28019981
61establishment of viral latency (GO:0019043)3.27276864
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.26028945
63DNA conformation change (GO:0071103)3.25900743
64* chromatin assembly or disassembly (GO:0006333)3.23895457
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22789899
66mitotic sister chromatid cohesion (GO:0007064)3.20740815
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20027426
68non-recombinational repair (GO:0000726)3.19624621
69double-strand break repair via nonhomologous end joining (GO:0006303)3.19624621
70cotranslational protein targeting to membrane (GO:0006613)3.19617869
71pseudouridine synthesis (GO:0001522)3.19474720
72DNA strand renaturation (GO:0000733)3.19336946
73rRNA processing (GO:0006364)3.18583748
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18062515
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17677768
76rRNA modification (GO:0000154)3.17071315
77mitotic spindle checkpoint (GO:0071174)3.15862743
78protein K6-linked ubiquitination (GO:0085020)3.15800441
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15087582
80protein complex localization (GO:0031503)3.15038863
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14726817
82negative regulation of mitotic sister chromatid separation (GO:2000816)3.14726817
83negative regulation of sister chromatid segregation (GO:0033046)3.14726817
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14726817
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14726817
86protein targeting to ER (GO:0045047)3.14654431
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09530369
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09530369
89viral mRNA export from host cell nucleus (GO:0046784)3.09285836
90rRNA metabolic process (GO:0016072)3.09268452
91cellular protein complex disassembly (GO:0043624)3.09240475
92transcription-coupled nucleotide-excision repair (GO:0006283)3.07499668
93regulation of sister chromatid segregation (GO:0033045)3.06159728
94regulation of mitotic sister chromatid separation (GO:0010965)3.06159728
95regulation of mitotic sister chromatid segregation (GO:0033047)3.06159728
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03863105
97telomere maintenance (GO:0000723)3.03713097
98mitotic spindle assembly checkpoint (GO:0007094)3.03376169
99replication fork processing (GO:0031297)3.03288359
100regulation of translational fidelity (GO:0006450)3.02985012
101ribonucleoprotein complex biogenesis (GO:0022613)3.02828659
102telomere organization (GO:0032200)3.02772788
103deoxyribonucleotide biosynthetic process (GO:0009263)3.02526539
104purine nucleobase biosynthetic process (GO:0009113)3.01891354
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01745543
106spindle assembly checkpoint (GO:0071173)3.00249729
107regulation of chromosome segregation (GO:0051983)3.00208626
108mismatch repair (GO:0006298)3.00205997
109establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00096313
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.99957277
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99957277
112chromosome segregation (GO:0007059)2.99473433
113regulation of centrosome duplication (GO:0010824)2.97839246
114ribosome assembly (GO:0042255)2.97263753
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97222233
116positive regulation of chromosome segregation (GO:0051984)2.96699635
117folic acid-containing compound biosynthetic process (GO:0009396)2.96695455
118pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96310548
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95915959
120viral life cycle (GO:0019058)2.95164183
121DNA synthesis involved in DNA repair (GO:0000731)2.95059169
122protein localization to endoplasmic reticulum (GO:0070972)2.94604207
123* ATP-dependent chromatin remodeling (GO:0043044)2.93789822
124regulation of histone H3-K9 methylation (GO:0051570)2.91720317
125spindle checkpoint (GO:0031577)2.91437886
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.91103752
127protein localization to chromosome (GO:0034502)2.90937747
128DNA duplex unwinding (GO:0032508)2.88629356
129regulation of spindle organization (GO:0090224)2.88134536
130DNA geometric change (GO:0032392)2.87811238
131spliceosomal snRNP assembly (GO:0000387)2.87696315
132base-excision repair, AP site formation (GO:0006285)2.87307542
133G1/S transition of mitotic cell cycle (GO:0000082)2.86595158
134cell cycle G1/S phase transition (GO:0044843)2.86595158
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86360819
136histone H2A acetylation (GO:0043968)2.83426657
137* mitotic cell cycle (GO:0000278)2.83415359
138base-excision repair (GO:0006284)2.82534300
139proteasome assembly (GO:0043248)2.81993760
140regulation of centrosome cycle (GO:0046605)2.80657864
141protein complex disassembly (GO:0043241)2.79484198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.82514289
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42810397
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.08572131
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58255854
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38774407
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21000155
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.18696228
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88571917
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.84463260
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.75730122
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73276904
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71579498
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69780493
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69766008
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44280705
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41527119
17VDR_23849224_ChIP-Seq_CD4+_Human2.39407441
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36002428
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35134467
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33313602
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27990083
22AR_21909140_ChIP-Seq_LNCAP_Human2.24063141
23XRN2_22483619_ChIP-Seq_HELA_Human2.23207381
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.22036080
25FOXP3_21729870_ChIP-Seq_TREG_Human2.14572912
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13565378
27CIITA_25753668_ChIP-Seq_RAJI_Human2.06251558
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03038621
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01028528
30E2F7_22180533_ChIP-Seq_HELA_Human10.1227476
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95215000
32DCP1A_22483619_ChIP-Seq_HELA_Human1.90788772
33TTF2_22483619_ChIP-Seq_HELA_Human1.86452114
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79939709
35ELK1_19687146_ChIP-ChIP_HELA_Human1.76506082
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75074091
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73265101
38* GABP_19822575_ChIP-Seq_HepG2_Human1.72442120
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72114816
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71844471
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66935996
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66246972
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.65365668
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65363040
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65067577
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57899085
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55043751
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53199476
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51975566
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.48575022
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.46644588
52MYC_22102868_ChIP-Seq_BL_Human1.41585758
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39807589
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39750089
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38868691
56KDM5A_27292631_Chip-Seq_BREAST_Human1.38566462
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36090630
58* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33530291
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33365668
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.33050808
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32234599
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25705292
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22546050
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21892212
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18639131
66MYC_18940864_ChIP-ChIP_HL60_Human1.17883693
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15930068
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.14700146
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08780542
70VDR_21846776_ChIP-Seq_THP-1_Human1.08082847
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07928429
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07776405
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07775141
74* SPI1_23547873_ChIP-Seq_NB4_Human1.06490930
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02466289
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01749324
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99431258
78* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99192559
79IRF1_19129219_ChIP-ChIP_H3396_Human0.96697309
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96503682
81SALL1_21062744_ChIP-ChIP_HESCs_Human0.96082737
82TFEB_21752829_ChIP-Seq_HELA_Human0.95390472
83NANOG_16153702_ChIP-ChIP_HESCs_Human0.94803723
84* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94782144
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93505254
86RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93054558
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92650185
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90741455
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89533831
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.87631657
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85050915
92ZNF263_19887448_ChIP-Seq_K562_Human0.84826453
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83231525
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83018212
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82000437
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81587740
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81322384
98GATA1_22025678_ChIP-Seq_K562_Human0.80815262
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79885457
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79450979
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78494356
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78069257
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.77956724
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77439323
105CHD1_26751641_Chip-Seq_LNCaP_Human0.77072268
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75788604
107* NANOG_21062744_ChIP-ChIP_HESCs_Human0.75652095
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.73819094
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73492826
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73088738
111TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70709009
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69625814
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69547485
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68093234
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66052205
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65407163
117MYB_26560356_Chip-Seq_TH2_Human0.64099732
118MYB_26560356_Chip-Seq_TH1_Human0.63608975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.72064952
2MP0003693_abnormal_embryo_hatching5.57310018
3MP0010094_abnormal_chromosome_stability5.06103665
4MP0003111_abnormal_nucleus_morphology4.60271284
5MP0004957_abnormal_blastocyst_morpholog4.44130992
6MP0003077_abnormal_cell_cycle4.14185548
7MP0008058_abnormal_DNA_repair3.76865651
8MP0008877_abnormal_DNA_methylation3.13014218
9MP0002396_abnormal_hematopoietic_system3.11025460
10MP0008007_abnormal_cellular_replicative2.89507679
11MP0008932_abnormal_embryonic_tissue2.83147708
12MP0010030_abnormal_orbit_morphology2.60835543
13MP0003123_paternal_imprinting2.25334367
14MP0003763_abnormal_thymus_physiology2.15917624
15MP0000350_abnormal_cell_proliferation2.10163211
16MP0003718_maternal_effect2.05649899
17MP0003786_premature_aging2.05478621
18MP0001730_embryonic_growth_arrest1.97807515
19MP0000490_abnormal_crypts_of1.79472576
20MP0003941_abnormal_skin_development1.78032921
21MP0000537_abnormal_urethra_morphology1.75122873
22MP0005397_hematopoietic_system_phenotyp1.75007630
23MP0001545_abnormal_hematopoietic_system1.75007630
24MP0001346_abnormal_lacrimal_gland1.72398718
25MP0000703_abnormal_thymus_morphology1.64577262
26MP0003705_abnormal_hypodermis_morpholog1.62966832
27MP0004808_abnormal_hematopoietic_stem1.59317222
28MP0002398_abnormal_bone_marrow1.59134361
29MP0002210_abnormal_sex_determination1.57237687
30MP0002019_abnormal_tumor_incidence1.56388443
31MP0003890_abnormal_embryonic-extraembry1.56137461
32MP0003121_genomic_imprinting1.54019847
33MP0009672_abnormal_birth_weight1.50129092
34MP0001929_abnormal_gametogenesis1.49371434
35MP0009333_abnormal_splenocyte_physiolog1.46737063
36MP0005076_abnormal_cell_differentiation1.46323233
37MP0009379_abnormal_foot_pigmentation1.44937430
38MP0002697_abnormal_eye_size1.43011000
39MP0002102_abnormal_ear_morphology1.40781538
40MP0000313_abnormal_cell_death1.40675188
41MP0001697_abnormal_embryo_size1.40428097
42MP0002938_white_spotting1.37631259
43MP0006292_abnormal_olfactory_placode1.36282490
44MP0000689_abnormal_spleen_morphology1.35208063
45MP0010307_abnormal_tumor_latency1.33640457
46MP0002722_abnormal_immune_system1.32765706
47MP0003136_yellow_coat_color1.32369694
48MP0001145_abnormal_male_reproductive1.28679764
49MP0002080_prenatal_lethality1.26477375
50MP0002085_abnormal_embryonic_tissue1.24835683
51MP0001672_abnormal_embryogenesis/_devel1.23918197
52MP0005380_embryogenesis_phenotype1.23918197
53MP0000653_abnormal_sex_gland1.21944140
54MP0002877_abnormal_melanocyte_morpholog1.21490415
55MP0001286_abnormal_eye_development1.19376574
56MP0005075_abnormal_melanosome_morpholog1.18618397
57MP0002429_abnormal_blood_cell1.15355412
58MP0001800_abnormal_humoral_immune1.13957564
59MP0000716_abnormal_immune_system1.11531510
60MP0004233_abnormal_muscle_weight1.08444217
61MP0000428_abnormal_craniofacial_morphol1.07572850
62MP0001119_abnormal_female_reproductive1.07024536
63MP0009697_abnormal_copulation1.06949974
64MP0003984_embryonic_growth_retardation1.05013274
65MP0003950_abnormal_plasma_membrane1.04637130
66MP0005171_absent_coat_pigmentation1.04240886
67MP0001986_abnormal_taste_sensitivity1.04108474
68MP0003567_abnormal_fetal_cardiomyocyte1.03044622
69MP0002088_abnormal_embryonic_growth/wei1.01321827
70MP0002111_abnormal_tail_morphology1.01060542
71MP0005174_abnormal_tail_pigmentation1.00131763
72MP0005671_abnormal_response_to0.99665869
73MP0002420_abnormal_adaptive_immunity0.99396763
74MP0001529_abnormal_vocalization0.98970710
75MP0002092_abnormal_eye_morphology0.98754134
76MP0003942_abnormal_urinary_system0.97915209
77MP0002084_abnormal_developmental_patter0.97039036
78MP0001819_abnormal_immune_cell0.96662527
79MP0002160_abnormal_reproductive_system0.95845068
80MP0002086_abnormal_extraembryonic_tissu0.94961841
81MP0005257_abnormal_intraocular_pressure0.92168309
82MP0002095_abnormal_skin_pigmentation0.91034258
83MP0003861_abnormal_nervous_system0.89468095
84MP0001835_abnormal_antigen_presentation0.88607486
85MP0002452_abnormal_antigen_presenting0.88443531
86MP0002723_abnormal_immune_serum0.86811128
87MP0000049_abnormal_middle_ear0.85656578
88MP0005501_abnormal_skin_physiology0.83973274
89MP0004185_abnormal_adipocyte_glucose0.83766363
90MP0006035_abnormal_mitochondrial_morpho0.83517766
91MP0003699_abnormal_female_reproductive0.82856897
92MP0000534_abnormal_ureter_morphology0.82769362
93MP0003698_abnormal_male_reproductive0.82178921
94MP0003755_abnormal_palate_morphology0.80157701
95MP0002234_abnormal_pharynx_morphology0.79220210
96MP0009703_decreased_birth_body0.78859040
97MP0003806_abnormal_nucleotide_metabolis0.78593521
98MP0000432_abnormal_head_morphology0.78257096
99MP0003385_abnormal_body_wall0.78242525
100MP0009053_abnormal_anal_canal0.77478143
101MP0001873_stomach_inflammation0.77378431
102MP0008789_abnormal_olfactory_epithelium0.77047886
103MP0000858_altered_metastatic_potential0.75455210
104MP0002233_abnormal_nose_morphology0.75370337
105MP0005384_cellular_phenotype0.75197499
106MP0000358_abnormal_cell_content/0.75039228
107MP0005389_reproductive_system_phenotype0.74043830
108MP0003315_abnormal_perineum_morphology0.73977740
109MP0003119_abnormal_digestive_system0.73729070
110MP0002161_abnormal_fertility/fecundity0.73330588
111MP0003935_abnormal_craniofacial_develop0.72523406
112MP0003646_muscle_fatigue0.72256952
113MP0000372_irregular_coat_pigmentation0.71593728
114MP0005621_abnormal_cell_physiology0.69816756
115MP0000762_abnormal_tongue_morphology0.69521258
116MP0001849_ear_inflammation0.69045360
117MP0000015_abnormal_ear_pigmentation0.68772999
118MP0010352_gastrointestinal_tract_polyps0.68136357
119MP0001293_anophthalmia0.67624626
120MP0002405_respiratory_system_inflammati0.67583381
121MP0005623_abnormal_meninges_morphology0.66966349
122MP0003566_abnormal_cell_adhesion0.66319511
123MP0000465_gastrointestinal_hemorrhage0.66257072
124MP0009278_abnormal_bone_marrow0.66149821
125MP0003787_abnormal_imprinting0.65196604
126MP0005395_other_phenotype0.64979897
127MP0009250_abnormal_appendicular_skeleto0.63210252
128MP0000627_abnormal_mammary_gland0.62314041
129MP0008995_early_reproductive_senescence0.61667787
130MP0003943_abnormal_hepatobiliary_system0.60889373
131MP0005408_hypopigmentation0.60822437
132MP0004197_abnormal_fetal_growth/weight/0.59896214
133MP0005409_darkened_coat_color0.59549118
134MP0002132_abnormal_respiratory_system0.58405187
135MP0005000_abnormal_immune_tolerance0.58301120
136MP0000383_abnormal_hair_follicle0.57562224
137MP0000685_abnormal_immune_system0.56236531
138MP0003656_abnormal_erythrocyte_physiolo0.56187733
139MP0005025_abnormal_response_to0.55434363
140MP0003937_abnormal_limbs/digits/tail_de0.55334255
141MP0002006_tumorigenesis0.52859147
142MP0002163_abnormal_gland_morphology0.52624616
143MP0002751_abnormal_autonomic_nervous0.50525209
144MP0002075_abnormal_coat/hair_pigmentati0.49888761
145MP0001919_abnormal_reproductive_system0.49407227
146MP0001853_heart_inflammation0.49207416
147MP0004133_heterotaxia0.48724012
148MP0008770_decreased_survivor_rate0.48396454

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.38561920
2Abnormality of cells of the erythroid lineage (HP:0012130)4.89423018
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.86693966
4Abnormal number of erythroid precursors (HP:0012131)4.67873038
5Reticulocytopenia (HP:0001896)4.58610064
6Birth length less than 3rd percentile (HP:0003561)4.30364668
7Aplastic anemia (HP:0001915)3.92587931
8Meckel diverticulum (HP:0002245)3.78180302
9Abnormality of the preputium (HP:0100587)3.77541962
10Abnormality of chromosome stability (HP:0003220)3.73229434
11Abnormality of the ileum (HP:0001549)3.64763022
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.50663188
13Increased nuchal translucency (HP:0010880)3.39254311
14Myelodysplasia (HP:0002863)3.20913522
15Pallor (HP:0000980)3.19533531
16Breast hypoplasia (HP:0003187)3.17836442
17Small intestinal stenosis (HP:0012848)3.08911125
18Duodenal stenosis (HP:0100867)3.08911125
19Patellar aplasia (HP:0006443)3.05774402
20Macrocytic anemia (HP:0001972)2.97203987
21Colon cancer (HP:0003003)2.90749093
22Bone marrow hypocellularity (HP:0005528)2.90630549
23Oral leukoplakia (HP:0002745)2.87330391
24Hypoplasia of the capital femoral epiphysis (HP:0003090)2.80656549
25Aplasia/Hypoplasia of the patella (HP:0006498)2.75533308
26IgM deficiency (HP:0002850)2.71379140
27Selective tooth agenesis (HP:0001592)2.63600337
28Agnosia (HP:0010524)2.63139882
29Abnormality of the labia minora (HP:0012880)2.59220376
30Carpal bone hypoplasia (HP:0001498)2.58271645
31Clubbing of toes (HP:0100760)2.57821035
32Impulsivity (HP:0100710)2.57362160
3311 pairs of ribs (HP:0000878)2.54977522
34Sloping forehead (HP:0000340)2.50461903
35Absent thumb (HP:0009777)2.47974655
36Triphalangeal thumb (HP:0001199)2.46702305
37Rough bone trabeculation (HP:0100670)2.45496005
38Irregular epiphyses (HP:0010582)2.44750808
39Abnormality of the duodenum (HP:0002246)2.39399013
40Proximal placement of thumb (HP:0009623)2.38191597
41Abnormality of the carotid arteries (HP:0005344)2.36691721
42Abnormal lung lobation (HP:0002101)2.31980911
43Microglossia (HP:0000171)2.30230243
44Premature graying of hair (HP:0002216)2.28778829
45Deviation of the thumb (HP:0009603)2.28757623
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27501719
47Absent epiphyses (HP:0010577)2.27501719
48Duplication of thumb phalanx (HP:0009942)2.26943366
49Cortical dysplasia (HP:0002539)2.26917955
50Acute lymphatic leukemia (HP:0006721)2.26267582
51Absent radius (HP:0003974)2.24519369
52Supernumerary spleens (HP:0009799)2.22005292
53Cellular immunodeficiency (HP:0005374)2.21124210
54Short thumb (HP:0009778)2.20498615
55Facial hemangioma (HP:0000329)2.20182846
56Tracheoesophageal fistula (HP:0002575)2.18816997
57Thrombocytosis (HP:0001894)2.18708837
58Premature ovarian failure (HP:0008209)2.17755526
59Secondary amenorrhea (HP:0000869)2.17411394
60Pancytopenia (HP:0001876)2.16787073
61Basal cell carcinoma (HP:0002671)2.15663680
62Absent forearm bone (HP:0003953)2.14940323
63Aplasia involving forearm bones (HP:0009822)2.14940323
64Lymphoma (HP:0002665)2.13910346
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12830309
66Choanal atresia (HP:0000453)2.10409106
67Prominent nose (HP:0000448)2.10156380
68Ectopic kidney (HP:0000086)2.09537146
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07866047
70Abnormality of DNA repair (HP:0003254)2.07604053
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.07379814
72Broad distal phalanx of finger (HP:0009836)2.06824944
73Duplicated collecting system (HP:0000081)2.06046445
74Abnormality of the renal collecting system (HP:0004742)2.04752516
75Poikiloderma (HP:0001029)2.04436164
76Horseshoe kidney (HP:0000085)2.04340860
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03704345
78Multiple enchondromatosis (HP:0005701)2.02280699
79Atresia of the external auditory canal (HP:0000413)2.01538710
80Nephroblastoma (Wilms tumor) (HP:0002667)1.98691375
81Overlapping toe (HP:0001845)1.98612072
82Abnormal umbilical cord blood vessels (HP:0011403)1.98020915
83Single umbilical artery (HP:0001195)1.98020915
84Abnormality of the fetal cardiovascular system (HP:0010948)1.98020915
85Facial cleft (HP:0002006)1.97527977
86High anterior hairline (HP:0009890)1.96837041
87Neoplasm of the pancreas (HP:0002894)1.95820625
88Pulmonary fibrosis (HP:0002206)1.95173871
89Abnormality of cochlea (HP:0000375)1.94680854
90Medulloblastoma (HP:0002885)1.94024617
91Microvesicular hepatic steatosis (HP:0001414)1.92494372
92Leukopenia (HP:0001882)1.91178438
93Asplenia (HP:0001746)1.89237242
94Ependymoma (HP:0002888)1.88505948
95Abnormal number of incisors (HP:0011064)1.87286870
96Abnormality of the umbilical cord (HP:0010881)1.86801294
97Rhabdomyosarcoma (HP:0002859)1.85895233
98Squamous cell carcinoma (HP:0002860)1.85839570
99Arteriovenous malformation (HP:0100026)1.85082109
100High pitched voice (HP:0001620)1.84609503
101Abnormality of the prostate (HP:0008775)1.84400817
102Increased hepatocellular lipid droplets (HP:0006565)1.83920079
103Abnormality of the anterior horn cell (HP:0006802)1.82120578
104Degeneration of anterior horn cells (HP:0002398)1.82120578
105Cafe-au-lait spot (HP:0000957)1.81344846
106Acute myeloid leukemia (HP:0004808)1.79921209
107Embryonal renal neoplasm (HP:0011794)1.78850274
108Volvulus (HP:0002580)1.76248934
109Petechiae (HP:0000967)1.74881211
110Microretrognathia (HP:0000308)1.74076737
111Type I transferrin isoform profile (HP:0003642)1.72580956
112Cleft eyelid (HP:0000625)1.72005251
113Exertional dyspnea (HP:0002875)1.71728225
114Rectovaginal fistula (HP:0000143)1.70189834
115Rectal fistula (HP:0100590)1.70189834
116Severe visual impairment (HP:0001141)1.68100121
117Cerebral hypomyelination (HP:0006808)1.67917415
118Abnormal spermatogenesis (HP:0008669)1.67536570
119Abnormal trabecular bone morphology (HP:0100671)1.66962834
120Abnormality of the columella (HP:0009929)1.66851032
121Urethral obstruction (HP:0000796)1.65755569
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.64965693
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.64910481
124Ulnar bowing (HP:0003031)1.60804932
125Hyperacusis (HP:0010780)1.60486496
126Abnormality of the phalanges of the hallux (HP:0010057)1.60035317
127Progressive muscle weakness (HP:0003323)1.59273745
128Intestinal fistula (HP:0100819)1.59238367
129Embryonal neoplasm (HP:0002898)1.58977676
130Missing ribs (HP:0000921)1.58535427
131Self-mutilation (HP:0000742)1.57614555
132Hypoplastic pelvis (HP:0008839)1.56974741
133Abnormality of glycolysis (HP:0004366)1.54629897
134Septate vagina (HP:0001153)1.54496977
135Cholecystitis (HP:0001082)1.52822413
136Abnormal gallbladder physiology (HP:0012438)1.52822413
137Astrocytoma (HP:0009592)1.52222200
138Abnormality of the astrocytes (HP:0100707)1.52222200
139Vaginal fistula (HP:0004320)1.50838899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.70583493
2WEE14.55958844
3BUB14.32693093
4VRK23.82545123
5EIF2AK12.90163290
6NEK22.63595530
7TTK2.58411661
8VRK12.55336682
9PBK2.48403981
10BRSK22.45817213
11PLK42.29404299
12PLK12.24094319
13SMG12.03477903
14SRPK12.02862702
15ACVR1B1.88831347
16PNCK1.86861225
17TLK11.86495798
18DYRK31.86334516
19AURKB1.83567492
20CCNB11.82143750
21STK161.76135867
22CDK71.71110142
23EIF2AK31.65876529
24ATR1.65299817
25CHEK21.64298678
26TSSK61.61983046
27NME21.60649194
28AURKA1.58624057
29TAF11.55576449
30TESK21.47960690
31CDK81.44519681
32PLK31.43326935
33MAP2K71.38119917
34MKNK11.37034890
35BRSK11.35591737
36RPS6KB21.33122007
37CDK41.33012770
38STK101.27816948
39MAP4K11.27151026
40NME11.26919350
41EEF2K1.25839050
42SCYL21.20201585
43TRIB31.19043860
44PASK1.16145078
45LATS11.14722692
46TEC1.12881277
47BRAF1.12868293
48MAP3K81.12647365
49CHEK11.10717343
50LATS21.10030793
51MKNK21.06670185
52TGFBR11.04205123
53CDK121.03837506
54ICK1.02071361
55NEK10.99855836
56KIT0.98160659
57TAOK10.97949812
58CLK10.94432469
59ZAK0.93214564
60STK40.92111885
61TRIM280.91118366
62RPS6KA40.87017584
63ATM0.85907334
64BRD40.83832702
65GRK60.80760556
66EIF2AK20.78889621
67CSF1R0.77915663
68IRAK30.75566175
69BTK0.74627200
70TXK0.73335524
71ERBB40.71650228
72CDK20.71176736
73MAP3K100.68405257
74STK30.67513199
75CSNK2A20.67401716
76STK38L0.66420130
77TAOK20.66018715
78PIM10.64781436
79CSNK2A10.61799505
80CDK10.61287511
81ALK0.60146433
82PKN20.57970628
83TYK20.57382168
84FLT30.56765978
85CDK190.56718357
86RPS6KA50.56544004
87NUAK10.55987918
88MAP3K40.54203899
89MELK0.54176002
90MTOR0.51933140
91EPHA20.51611259
92TGFBR20.50327645
93CDK30.49823485
94CDK90.49568071
95MAP3K60.48832007
96CDK180.47269805
97CDK11A0.46839026
98CDK150.46837238
99RAF10.46382711
100LYN0.45804135
101IRAK40.44207077
102MST1R0.43972496
103MET0.43669697
104PRKCI0.43521342
105CDK60.43212444
106ILK0.43130804
107SYK0.42358889
108MAPKAPK30.42260298
109DAPK10.40223093
110FGFR10.39345831
111AKT20.38230916
112GRK70.38137058
113PTK20.36707333
114PAK10.36459413
115CDK140.36419510
116PAK20.35967814
117CSNK1E0.35465476
118MST40.34589751
119PLK20.32891871
120PDGFRA0.32174226
121KDR0.30350646
122STK240.30335393
123PAK40.30051182
124LRRK20.29428033
125LCK0.29404459
126CAMK1G0.28975005
127MAPK140.28654340
128CSNK1G30.27176368
129NLK0.25893669
130MAPKAPK50.25596823
131TNIK0.23195731
132DYRK20.23163751
133BMPR1B0.23116707
134ZAP700.23094448
135PRKDC0.22796725

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.51723251
2Mismatch repair_Homo sapiens_hsa034304.48027070
3Homologous recombination_Homo sapiens_hsa034403.63548989
4Ribosome_Homo sapiens_hsa030103.52660430
5Base excision repair_Homo sapiens_hsa034103.38709628
6RNA polymerase_Homo sapiens_hsa030203.05855791
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01400643
8Cell cycle_Homo sapiens_hsa041102.93895744
9Nucleotide excision repair_Homo sapiens_hsa034202.90069804
10Spliceosome_Homo sapiens_hsa030402.88637988
11Proteasome_Homo sapiens_hsa030502.80252789
12Fanconi anemia pathway_Homo sapiens_hsa034602.78783492
13RNA transport_Homo sapiens_hsa030132.74589940
14Non-homologous end-joining_Homo sapiens_hsa034502.68135389
15Pyrimidine metabolism_Homo sapiens_hsa002402.57503906
16One carbon pool by folate_Homo sapiens_hsa006702.11228921
17Basal transcription factors_Homo sapiens_hsa030222.05091596
18RNA degradation_Homo sapiens_hsa030182.00826794
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89820618
20p53 signaling pathway_Homo sapiens_hsa041151.53001086
21Systemic lupus erythematosus_Homo sapiens_hsa053221.45546602
22Purine metabolism_Homo sapiens_hsa002301.40931694
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27575800
24mRNA surveillance pathway_Homo sapiens_hsa030151.26178238
25Epstein-Barr virus infection_Homo sapiens_hsa051691.15965613
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13243649
27Primary immunodeficiency_Homo sapiens_hsa053401.10996542
28Oocyte meiosis_Homo sapiens_hsa041141.07793299
29Protein export_Homo sapiens_hsa030601.07356318
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05230058
31Pyruvate metabolism_Homo sapiens_hsa006201.00214455
32Herpes simplex infection_Homo sapiens_hsa051680.98267531
33Lysine degradation_Homo sapiens_hsa003100.96781394
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94809267
35Viral carcinogenesis_Homo sapiens_hsa052030.92570298
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91165614
37Antigen processing and presentation_Homo sapiens_hsa046120.90458711
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84673796
39Huntingtons disease_Homo sapiens_hsa050160.83996956
40Carbon metabolism_Homo sapiens_hsa012000.81664882
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81165991
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.80221507
43Alcoholism_Homo sapiens_hsa050340.79096070
44Basal cell carcinoma_Homo sapiens_hsa052170.77494320
45Hippo signaling pathway_Homo sapiens_hsa043900.75839466
46HTLV-I infection_Homo sapiens_hsa051660.71846575
47Selenocompound metabolism_Homo sapiens_hsa004500.70896706
48Steroid biosynthesis_Homo sapiens_hsa001000.70174091
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70163411
50Oxidative phosphorylation_Homo sapiens_hsa001900.68913272
51Hematopoietic cell lineage_Homo sapiens_hsa046400.64361724
52Bladder cancer_Homo sapiens_hsa052190.64223410
53Parkinsons disease_Homo sapiens_hsa050120.64206165
54Adherens junction_Homo sapiens_hsa045200.62747371
55Linoleic acid metabolism_Homo sapiens_hsa005910.62242553
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61301993
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.60076121
58N-Glycan biosynthesis_Homo sapiens_hsa005100.58926075
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56985149
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56630297
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55620246
62Fatty acid elongation_Homo sapiens_hsa000620.55496464
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54709508
64Sulfur relay system_Homo sapiens_hsa041220.53758691
65Hepatitis B_Homo sapiens_hsa051610.51724780
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.51281586
67Thyroid cancer_Homo sapiens_hsa052160.49401884
68MicroRNAs in cancer_Homo sapiens_hsa052060.48277091
69Pentose phosphate pathway_Homo sapiens_hsa000300.46709442
70Wnt signaling pathway_Homo sapiens_hsa043100.46216070
71Colorectal cancer_Homo sapiens_hsa052100.45299793
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45190064
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44532221
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44247694
75Hedgehog signaling pathway_Homo sapiens_hsa043400.43463016
76Measles_Homo sapiens_hsa051620.42918446
77Small cell lung cancer_Homo sapiens_hsa052220.42655317
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42419554
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42231277
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41867034
81Vitamin B6 metabolism_Homo sapiens_hsa007500.41456307
82B cell receptor signaling pathway_Homo sapiens_hsa046620.40777951
83Other glycan degradation_Homo sapiens_hsa005110.38898618
84Shigellosis_Homo sapiens_hsa051310.38722698
85Arachidonic acid metabolism_Homo sapiens_hsa005900.38700939
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37191481
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35573342
88Folate biosynthesis_Homo sapiens_hsa007900.34899868
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34087169
90Melanoma_Homo sapiens_hsa052180.33971979
91Apoptosis_Homo sapiens_hsa042100.32345466
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30491241
93Non-small cell lung cancer_Homo sapiens_hsa052230.30324394
94Galactose metabolism_Homo sapiens_hsa000520.29762502
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.29703907
96Pancreatic cancer_Homo sapiens_hsa052120.29605526
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28657062
98T cell receptor signaling pathway_Homo sapiens_hsa046600.28160301
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.27876251
100Fructose and mannose metabolism_Homo sapiens_hsa000510.27764001
101Propanoate metabolism_Homo sapiens_hsa006400.27528404
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.25850126
103Alzheimers disease_Homo sapiens_hsa050100.24418456
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24373526
105Glutathione metabolism_Homo sapiens_hsa004800.23440429
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22517200
107Legionellosis_Homo sapiens_hsa051340.22414651
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21734860
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20850160
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20606722
111Ether lipid metabolism_Homo sapiens_hsa005650.20421756
112Pathways in cancer_Homo sapiens_hsa052000.20142139
113Acute myeloid leukemia_Homo sapiens_hsa052210.19610935
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19105003
115Metabolic pathways_Homo sapiens_hsa011000.16737682
116Influenza A_Homo sapiens_hsa051640.15864409
117Glioma_Homo sapiens_hsa052140.15713978
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.14469748
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13738595
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13559966
121Chronic myeloid leukemia_Homo sapiens_hsa052200.12534386
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12312545
123Proteoglycans in cancer_Homo sapiens_hsa052050.11192221
124TGF-beta signaling pathway_Homo sapiens_hsa043500.10678955
125Regulation of autophagy_Homo sapiens_hsa041400.10539410
126Arginine and proline metabolism_Homo sapiens_hsa003300.10282637
127Asthma_Homo sapiens_hsa053100.08474805
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07421994
129Prostate cancer_Homo sapiens_hsa052150.07292954
130Allograft rejection_Homo sapiens_hsa053300.05823590
131Biosynthesis of amino acids_Homo sapiens_hsa012300.05716309
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04038669
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03206049
134Leishmaniasis_Homo sapiens_hsa051400.03021791
135Renin-angiotensin system_Homo sapiens_hsa046140.02821189

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