CENPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.24638556
2telomere maintenance via semi-conservative replication (GO:0032201)5.12311872
3protein localization to kinetochore (GO:0034501)5.06041459
4* CENP-A containing nucleosome assembly (GO:0034080)5.02116570
5DNA strand elongation (GO:0022616)4.98251155
6DNA replication initiation (GO:0006270)4.96720296
7* chromatin remodeling at centromere (GO:0031055)4.93585819
8mitotic metaphase plate congression (GO:0007080)4.93562375
9DNA replication checkpoint (GO:0000076)4.87345076
10kinetochore organization (GO:0051383)4.79485336
11telomere maintenance via recombination (GO:0000722)4.72187935
12protein localization to chromosome, centromeric region (GO:0071459)4.61442224
13mitotic recombination (GO:0006312)4.56715693
14DNA unwinding involved in DNA replication (GO:0006268)4.54966405
15attachment of spindle microtubules to kinetochore (GO:0008608)4.49425752
16* DNA replication-independent nucleosome organization (GO:0034724)4.40372943
17* DNA replication-independent nucleosome assembly (GO:0006336)4.40372943
18metaphase plate congression (GO:0051310)4.39258718
19kinetochore assembly (GO:0051382)4.33092460
20mitotic chromosome condensation (GO:0007076)4.26372753
21* histone exchange (GO:0043486)4.22537350
22telomere maintenance via telomere lengthening (GO:0010833)4.15342318
23establishment of chromosome localization (GO:0051303)4.09555143
24DNA replication-dependent nucleosome assembly (GO:0006335)4.05102256
25DNA replication-dependent nucleosome organization (GO:0034723)4.05102256
26mitotic sister chromatid segregation (GO:0000070)4.03968207
27nucleotide-excision repair, DNA gap filling (GO:0006297)3.99332288
28DNA topological change (GO:0006265)3.95729675
29nucleobase biosynthetic process (GO:0046112)3.95726083
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.91685153
31mitotic nuclear envelope disassembly (GO:0007077)3.86208481
32translesion synthesis (GO:0019985)3.84225413
33regulation of spindle organization (GO:0090224)3.83766190
34ribosomal small subunit assembly (GO:0000028)3.82661366
35maturation of SSU-rRNA (GO:0030490)3.82570187
36DNA deamination (GO:0045006)3.82392695
37meiotic chromosome segregation (GO:0045132)3.81964478
38synapsis (GO:0007129)3.79025706
39mitotic sister chromatid cohesion (GO:0007064)3.77155677
40purine nucleobase biosynthetic process (GO:0009113)3.73315581
41formation of translation preinitiation complex (GO:0001731)3.68741035
42sister chromatid segregation (GO:0000819)3.68373341
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62781598
44spindle checkpoint (GO:0031577)3.55062663
45nuclear envelope disassembly (GO:0051081)3.54369482
46membrane disassembly (GO:0030397)3.54369482
47nuclear pore organization (GO:0006999)3.50230547
48regulation of chromosome segregation (GO:0051983)3.42697684
49negative regulation of chromosome segregation (GO:0051985)3.40280498
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.40187623
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.40187623
52negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.40187623
53negative regulation of sister chromatid segregation (GO:0033046)3.40187623
54protein localization to chromosome (GO:0034502)3.39956577
55regulation of centriole replication (GO:0046599)3.39599029
56regulation of histone H3-K9 methylation (GO:0051570)3.37755322
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37272197
58regulation of double-strand break repair via homologous recombination (GO:0010569)3.36399851
59ribosome assembly (GO:0042255)3.35988310
60spindle assembly checkpoint (GO:0071173)3.35190475
61nuclear pore complex assembly (GO:0051292)3.35169942
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.34673162
63chromosome segregation (GO:0007059)3.33956219
64postreplication repair (GO:0006301)3.33773587
65regulation of DNA endoreduplication (GO:0032875)3.33603924
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32853345
67proteasome assembly (GO:0043248)3.29880506
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.29868699
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28854631
70sister chromatid cohesion (GO:0007062)3.28804605
71mitotic spindle assembly checkpoint (GO:0007094)3.26687794
72transcription-coupled nucleotide-excision repair (GO:0006283)3.26391907
73regulation of mitotic spindle organization (GO:0060236)3.25345257
74ribosome biogenesis (GO:0042254)3.24585805
75ribosomal large subunit biogenesis (GO:0042273)3.24231301
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23444802
77* chromatin assembly or disassembly (GO:0006333)3.22463411
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21936355
79telomere maintenance (GO:0000723)3.21675972
80spliceosomal snRNP assembly (GO:0000387)3.21402284
81telomere organization (GO:0032200)3.21348077
82deoxyribonucleotide biosynthetic process (GO:0009263)3.21104556
83mitotic spindle checkpoint (GO:0071174)3.21081196
84positive regulation of chromosome segregation (GO:0051984)3.20560225
85positive regulation of histone H3-K4 methylation (GO:0051571)3.20013593
86replication fork processing (GO:0031297)3.19564617
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.18801206
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18801206
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18801206
90mitotic G2/M transition checkpoint (GO:0044818)3.17972937
91ribonucleoprotein complex biogenesis (GO:0022613)3.17788353
92DNA ligation (GO:0006266)3.17429450
93IMP biosynthetic process (GO:0006188)3.17132226
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16123696
95* ATP-dependent chromatin remodeling (GO:0043044)3.13232176
96regulation of mitotic sister chromatid separation (GO:0010965)3.12744311
97regulation of mitotic sister chromatid segregation (GO:0033047)3.12744311
98regulation of sister chromatid segregation (GO:0033045)3.12744311
99chromosome organization involved in meiosis (GO:0070192)3.11995373
100cell cycle G1/S phase transition (GO:0044843)3.11517133
101G1/S transition of mitotic cell cycle (GO:0000082)3.11517133
102rRNA processing (GO:0006364)3.10839177
103pseudouridine synthesis (GO:0001522)3.10453999
104base-excision repair (GO:0006284)3.09872671
105DNA replication (GO:0006260)3.09646148
106translational termination (GO:0006415)3.09150729
107ribosomal small subunit biogenesis (GO:0042274)3.08847735
108regulation of centrosome cycle (GO:0046605)3.08518240
109centriole replication (GO:0007099)3.08334726
110regulation of mitochondrial translation (GO:0070129)3.08085394
111viral transcription (GO:0019083)3.07576014
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07056478
113regulation of mitotic spindle checkpoint (GO:1903504)3.07056478
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06963109
115* mitotic cell cycle (GO:0000278)3.06351205
116viral mRNA export from host cell nucleus (GO:0046784)3.05987961
117DNA catabolic process, exonucleolytic (GO:0000738)3.05091500
118mismatch repair (GO:0006298)3.05089251
119regulation of DNA methylation (GO:0044030)3.05032148
120regulation of sister chromatid cohesion (GO:0007063)3.04735730
121protein K6-linked ubiquitination (GO:0085020)3.02885108
122establishment of integrated proviral latency (GO:0075713)3.01437637
123chromosome condensation (GO:0030261)3.00887746
124DNA packaging (GO:0006323)3.00649171
125DNA duplex unwinding (GO:0032508)3.00641815
126rRNA metabolic process (GO:0016072)3.00635108
127regulation of spindle checkpoint (GO:0090231)2.99607872
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99554080
129DNA geometric change (GO:0032392)2.99540542
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.92471980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.76828610
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.08332498
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31230248
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.15434303
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.72721679
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61190647
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40295085
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.02377366
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.90388949
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86543398
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78679475
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77517298
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77165366
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74098794
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.69949711
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64804342
17AR_21909140_ChIP-Seq_LNCAP_Human2.61976370
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53403947
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36309677
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30442272
21* XRN2_22483619_ChIP-Seq_HELA_Human2.24057250
22VDR_23849224_ChIP-Seq_CD4+_Human2.20631929
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.20255719
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12093143
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08126070
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01637924
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99625461
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99220645
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.97469664
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95790208
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92189210
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88164972
33* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83261938
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82083594
35* TTF2_22483619_ChIP-Seq_HELA_Human1.81240856
36GABP_19822575_ChIP-Seq_HepG2_Human1.80637948
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78505460
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77037141
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71895426
40ELK1_19687146_ChIP-ChIP_HELA_Human1.71737694
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67713077
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67104684
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61911769
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61472943
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60741407
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58522056
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54315643
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45582419
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45170916
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.43736522
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.43108351
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.42961121
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42462739
54CIITA_25753668_ChIP-Seq_RAJI_Human1.40537637
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39247393
56KDM5A_27292631_Chip-Seq_BREAST_Human1.37673799
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29378923
58* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28811140
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22498755
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21080826
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20945236
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19364479
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17964218
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16332814
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13196557
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11190784
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10441928
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.08571485
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06711768
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05736957
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05270433
72MYC_18940864_ChIP-ChIP_HL60_Human1.04550828
73MYC_22102868_ChIP-Seq_BL_Human1.04014792
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02747119
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02736788
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02681958
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.00061833
78* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99153979
79GATA1_22025678_ChIP-Seq_K562_Human0.97299543
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96894447
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95613962
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95152882
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94191317
84TFEB_21752829_ChIP-Seq_HELA_Human0.94135485
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93771739
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93351814
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91539760
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90005513
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88719317
90EWS_26573619_Chip-Seq_HEK293_Human0.85995922
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85562187
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82395132
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.81436970
94* SPI1_23547873_ChIP-Seq_NB4_Human0.81243148
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80151398
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.76573784
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.76465897
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75173766
99CHD1_26751641_Chip-Seq_LNCaP_Human0.72821666
100IRF1_19129219_ChIP-ChIP_H3396_Human0.71819676
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71651208
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.70963140
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70405356
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66972922
105VDR_21846776_ChIP-Seq_THP-1_Human0.66543590
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.66330695
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.66328560
108PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66123394
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.65916993
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.65631802
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65630365
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65596633
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64930185
114FUS_26573619_Chip-Seq_HEK293_Human0.62121030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.94035391
2MP0010094_abnormal_chromosome_stability5.36466452
3MP0003111_abnormal_nucleus_morphology4.93105536
4MP0008057_abnormal_DNA_replication4.82462928
5MP0004957_abnormal_blastocyst_morpholog4.63194414
6MP0003077_abnormal_cell_cycle4.44439736
7MP0008058_abnormal_DNA_repair3.72485553
8MP0008007_abnormal_cellular_replicative2.95469998
9MP0008932_abnormal_embryonic_tissue2.93078885
10MP0008877_abnormal_DNA_methylation2.65649770
11MP0002396_abnormal_hematopoietic_system2.62681485
12MP0001730_embryonic_growth_arrest2.26244882
13MP0000350_abnormal_cell_proliferation2.24681109
14MP0003123_paternal_imprinting2.24203753
15MP0003786_premature_aging2.22887828
16MP0010307_abnormal_tumor_latency1.95016566
17MP0003718_maternal_effect1.92223733
18MP0000490_abnormal_crypts_of1.79027338
19MP0001697_abnormal_embryo_size1.72108136
20MP0001672_abnormal_embryogenesis/_devel1.63507799
21MP0005380_embryogenesis_phenotype1.63507799
22MP0002210_abnormal_sex_determination1.60500903
23MP0002796_impaired_skin_barrier1.58477866
24MP0000313_abnormal_cell_death1.56314648
25MP0005501_abnormal_skin_physiology1.52255040
26MP0002080_prenatal_lethality1.50106270
27MP0003315_abnormal_perineum_morphology1.49470496
28MP0000015_abnormal_ear_pigmentation1.47213229
29MP0002085_abnormal_embryonic_tissue1.46069378
30MP0001929_abnormal_gametogenesis1.45313623
31MP0002019_abnormal_tumor_incidence1.44015604
32MP0003984_embryonic_growth_retardation1.43139603
33MP0010352_gastrointestinal_tract_polyps1.42289968
34MP0008789_abnormal_olfactory_epithelium1.41630436
35MP0002088_abnormal_embryonic_growth/wei1.38881017
36MP0004808_abnormal_hematopoietic_stem1.38652656
37MP0001145_abnormal_male_reproductive1.36938674
38MP0003806_abnormal_nucleotide_metabolis1.36710285
39MP0003121_genomic_imprinting1.31774081
40MP0005174_abnormal_tail_pigmentation1.28003744
41MP0003567_abnormal_fetal_cardiomyocyte1.27422611
42MP0002084_abnormal_developmental_patter1.25215858
43MP0001293_anophthalmia1.25079243
44MP0002086_abnormal_extraembryonic_tissu1.23667501
45MP0000653_abnormal_sex_gland1.21279466
46MP0004197_abnormal_fetal_growth/weight/1.18103643
47MP0006292_abnormal_olfactory_placode1.12514171
48MP0005397_hematopoietic_system_phenotyp1.09671404
49MP0001545_abnormal_hematopoietic_system1.09671404
50MP0009333_abnormal_splenocyte_physiolog1.09381904
51MP0003186_abnormal_redox_activity1.05518139
52MP0006054_spinal_hemorrhage1.04838035
53MP0000372_irregular_coat_pigmentation1.04826183
54MP0005394_taste/olfaction_phenotype1.02394835
55MP0005499_abnormal_olfactory_system1.02394835
56MP0001119_abnormal_female_reproductive1.00409560
57MP0002638_abnormal_pupillary_reflex0.98589747
58MP0000703_abnormal_thymus_morphology0.97928194
59MP0004233_abnormal_muscle_weight0.97115325
60MP0002132_abnormal_respiratory_system0.96990733
61MP0005075_abnormal_melanosome_morpholog0.96657011
62MP0003763_abnormal_thymus_physiology0.95833067
63MP0003890_abnormal_embryonic-extraembry0.95562991
64MP0002102_abnormal_ear_morphology0.93773307
65MP0003136_yellow_coat_color0.93422299
66MP0010234_abnormal_vibrissa_follicle0.93302409
67MP0005171_absent_coat_pigmentation0.92961044
68MP0002160_abnormal_reproductive_system0.91387552
69MP0002234_abnormal_pharynx_morphology0.90077510
70MP0005647_abnormal_sex_gland0.88403881
71MP0002398_abnormal_bone_marrow0.87747035
72MP0010030_abnormal_orbit_morphology0.86152950
73MP0002722_abnormal_immune_system0.85642335
74MP0004133_heterotaxia0.84401386
75MP0000689_abnormal_spleen_morphology0.82770031
76MP0003941_abnormal_skin_development0.80946225
77MP0000358_abnormal_cell_content/0.79182017
78MP0004147_increased_porphyrin_level0.78703865
79MP0003937_abnormal_limbs/digits/tail_de0.77138121
80MP0003698_abnormal_male_reproductive0.76557176
81MP0000858_altered_metastatic_potential0.76355153
82MP0001188_hyperpigmentation0.76261881
83MP0005389_reproductive_system_phenotype0.74161516
84MP0002163_abnormal_gland_morphology0.73913208
85MP0005384_cellular_phenotype0.73716840
86MP0005076_abnormal_cell_differentiation0.73617628
87MP0002009_preneoplasia0.71264455
88MP0006036_abnormal_mitochondrial_physio0.70851721
89MP0008995_early_reproductive_senescence0.69521214
90MP0002429_abnormal_blood_cell0.69481099
91MP0000537_abnormal_urethra_morphology0.68660238
92MP0009053_abnormal_anal_canal0.67864217
93MP0002161_abnormal_fertility/fecundity0.67069619
94MP0002877_abnormal_melanocyte_morpholog0.66603901
95MP0004381_abnormal_hair_follicle0.65750255
96MP0005621_abnormal_cell_physiology0.65488248
97MP0002938_white_spotting0.65423151
98MP0003950_abnormal_plasma_membrane0.65252902
99MP0002111_abnormal_tail_morphology0.64115764
100MP0002095_abnormal_skin_pigmentation0.63332034
101MP0005083_abnormal_biliary_tract0.62748586
102MP0001919_abnormal_reproductive_system0.62019474
103MP0003119_abnormal_digestive_system0.61206409
104MP0003453_abnormal_keratinocyte_physiol0.60948677
105MP0003699_abnormal_female_reproductive0.60520701
106MP0003787_abnormal_imprinting0.60091991
107MP0002092_abnormal_eye_morphology0.58837640
108MP0006072_abnormal_retinal_apoptosis0.58608076
109MP0003221_abnormal_cardiomyocyte_apopto0.58418671
110MP0009672_abnormal_birth_weight0.57581096
111MP0003656_abnormal_erythrocyte_physiolo0.55396894
112MP0002075_abnormal_coat/hair_pigmentati0.53940802
113MP0001286_abnormal_eye_development0.53888138
114MP0009697_abnormal_copulation0.53767638
115MP0002177_abnormal_outer_ear0.53035202
116MP0001661_extended_life_span0.52654747
117MP0005023_abnormal_wound_healing0.52199246
118MP0005266_abnormal_metabolism0.51685280
119MP0001216_abnormal_epidermal_layer0.51650727
120MP0000427_abnormal_hair_cycle0.51485170
121MP0001915_intracranial_hemorrhage0.51177061
122MP0000428_abnormal_craniofacial_morphol0.51153198
123MP0000716_abnormal_immune_system0.50860352
124MP0009379_abnormal_foot_pigmentation0.50730387
125MP0002653_abnormal_ependyma_morphology0.50456713
126MP0006035_abnormal_mitochondrial_morpho0.50395896
127MP0002233_abnormal_nose_morphology0.50393151
128MP0005408_hypopigmentation0.50228190
129MP0000477_abnormal_intestine_morphology0.50216746
130MP0001727_abnormal_embryo_implantation0.50080430
131MP0000371_diluted_coat_color0.49438572
132MP0005410_abnormal_fertilization0.47072213
133MP0005395_other_phenotype0.45852381

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.60771928
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.47966210
3Birth length less than 3rd percentile (HP:0003561)5.35722245
4Reticulocytopenia (HP:0001896)4.45407501
5Breast hypoplasia (HP:0003187)4.24740929
6Abnormality of chromosome stability (HP:0003220)4.16466315
7Meckel diverticulum (HP:0002245)4.03340317
8Abnormality of the preputium (HP:0100587)3.92367425
9Abnormality of cells of the erythroid lineage (HP:0012130)3.89949857
10Abnormal number of erythroid precursors (HP:0012131)3.83988524
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.81252640
12Abnormality of the ileum (HP:0001549)3.79395338
13Oral leukoplakia (HP:0002745)3.76287080
14Carpal bone hypoplasia (HP:0001498)3.73200835
15Patellar aplasia (HP:0006443)3.56438503
16Duodenal stenosis (HP:0100867)3.49496518
17Small intestinal stenosis (HP:0012848)3.49496518
18Aplastic anemia (HP:0001915)3.49485202
19Aplasia/Hypoplasia of the patella (HP:0006498)3.29629826
20Colon cancer (HP:0003003)3.22828675
21Selective tooth agenesis (HP:0001592)3.18664984
22Microvesicular hepatic steatosis (HP:0001414)3.16303401
23Degeneration of anterior horn cells (HP:0002398)3.12755496
24Abnormality of the anterior horn cell (HP:0006802)3.12755496
25Myelodysplasia (HP:0002863)2.99012190
26Rough bone trabeculation (HP:0100670)2.97376372
27Absent radius (HP:0003974)2.97259364
28Duplicated collecting system (HP:0000081)2.96908063
29Medulloblastoma (HP:0002885)2.94309941
30Bone marrow hypocellularity (HP:0005528)2.92879168
31Impulsivity (HP:0100710)2.89529675
32Absent thumb (HP:0009777)2.87990529
33Abnormal lung lobation (HP:0002101)2.86400264
34Abnormality of the duodenum (HP:0002246)2.81429292
35Aplasia involving forearm bones (HP:0009822)2.74231892
36Absent forearm bone (HP:0003953)2.74231892
37Sloping forehead (HP:0000340)2.68693924
38Abnormal number of incisors (HP:0011064)2.67813204
39Ectopic kidney (HP:0000086)2.65523821
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64334615
41Cerebral hypomyelination (HP:0006808)2.62979391
42Microretrognathia (HP:0000308)2.62150585
43Acute necrotizing encephalopathy (HP:0006965)2.60803245
44Sensory axonal neuropathy (HP:0003390)2.60626347
45Triphalangeal thumb (HP:0001199)2.60382958
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58078329
47Pallor (HP:0000980)2.56883173
4811 pairs of ribs (HP:0000878)2.56173412
49Rhabdomyosarcoma (HP:0002859)2.55005413
50Macrocytic anemia (HP:0001972)2.54694441
51Abnormality of the renal collecting system (HP:0004742)2.52324400
52Clubbing of toes (HP:0100760)2.52140912
53Horseshoe kidney (HP:0000085)2.49939934
54Supernumerary spleens (HP:0009799)2.49903654
55Premature graying of hair (HP:0002216)2.49737520
56Increased CSF lactate (HP:0002490)2.46396608
57Progressive muscle weakness (HP:0003323)2.45414353
58Agnosia (HP:0010524)2.43905651
59Abnormality of the carotid arteries (HP:0005344)2.43623383
60Ependymoma (HP:0002888)2.40845066
61Abnormal mitochondria in muscle tissue (HP:0008316)2.40781456
62Tracheoesophageal fistula (HP:0002575)2.40583723
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35863843
64Short thumb (HP:0009778)2.35500236
65Neoplasm of the pancreas (HP:0002894)2.33928670
66Nephroblastoma (Wilms tumor) (HP:0002667)2.28574098
67Mitochondrial inheritance (HP:0001427)2.24667448
68Acute encephalopathy (HP:0006846)2.24271667
69Abnormality of the labia minora (HP:0012880)2.24143739
70Megaloblastic anemia (HP:0001889)2.22561732
71Increased nuchal translucency (HP:0010880)2.22259510
72Pancytopenia (HP:0001876)2.19703174
73Lip pit (HP:0100267)2.17777372
74Cleft eyelid (HP:0000625)2.16618473
75Cellular immunodeficiency (HP:0005374)2.16365050
76Atresia of the external auditory canal (HP:0000413)2.15580827
77Increased hepatocellular lipid droplets (HP:0006565)2.14119159
78Abnormality of pyrimidine metabolism (HP:0004353)2.12226627
79Hepatic necrosis (HP:0002605)2.12222352
80Embryonal renal neoplasm (HP:0011794)2.10720590
81Cafe-au-lait spot (HP:0000957)2.09999596
82Abnormal spermatogenesis (HP:0008669)2.09741436
83Abnormal trabecular bone morphology (HP:0100671)2.08864395
84Secondary amenorrhea (HP:0000869)2.08430562
85Increased serum pyruvate (HP:0003542)2.06749801
86Hepatocellular necrosis (HP:0001404)2.05082102
87Poikiloderma (HP:0001029)2.01575081
88Abnormality of the heme biosynthetic pathway (HP:0010472)2.00845005
89Irregular epiphyses (HP:0010582)2.00704035
90Lipid accumulation in hepatocytes (HP:0006561)2.00245646
91Arteriovenous malformation (HP:0100026)1.99034489
92Neoplasm of the colon (HP:0100273)1.98926311
93Premature ovarian failure (HP:0008209)1.98324665
94Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98298068
95Progressive macrocephaly (HP:0004481)1.98140871
96Sparse eyelashes (HP:0000653)1.95702452
97Testicular atrophy (HP:0000029)1.94702764
98Aplasia/Hypoplasia of the sternum (HP:0006714)1.93672666
99Increased serum lactate (HP:0002151)1.92809569
100Abnormality of homocysteine metabolism (HP:0010919)1.90616214
101Homocystinuria (HP:0002156)1.90616214
102Cerebral edema (HP:0002181)1.89094691
103Proximal placement of thumb (HP:0009623)1.89088484
104Type I transferrin isoform profile (HP:0003642)1.88605507
105Lymphoma (HP:0002665)1.86929933
106Ureteral duplication (HP:0000073)1.86794581
107Multiple enchondromatosis (HP:0005701)1.85017748
108Prominent nose (HP:0000448)1.83108203
109Short middle phalanx of the 5th finger (HP:0004220)1.81954289
110Abnormality of chromosome segregation (HP:0002916)1.81510320
111Trismus (HP:0000211)1.81332419
112Deviation of the thumb (HP:0009603)1.81191885
113Abnormality of glycolysis (HP:0004366)1.81042687
114Abnormality of abdominal situs (HP:0011620)1.80560798
115Abdominal situs inversus (HP:0003363)1.80560798
116Progressive external ophthalmoplegia (HP:0000590)1.80494871
117Abnormality of reticulocytes (HP:0004312)1.79861505
118Slender long bone (HP:0003100)1.76424207
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76339882
120Absent epiphyses (HP:0010577)1.76339882
121Choanal atresia (HP:0000453)1.76133151
122Basal cell carcinoma (HP:0002671)1.75032530
123High pitched voice (HP:0001620)1.74940397
124Volvulus (HP:0002580)1.72119100
125Facial hemangioma (HP:0000329)1.71635269
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70236520
127Thrombocytosis (HP:0001894)1.69999540
128Abnormality of DNA repair (HP:0003254)1.69873713
129Squamous cell carcinoma (HP:0002860)1.68457599
130Amaurosis fugax (HP:0100576)1.68150062
131Prostate neoplasm (HP:0100787)1.67794217
132Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.66871726
133Decreased activity of mitochondrial respiratory chain (HP:0008972)1.66871726
134Leukopenia (HP:0001882)1.66795187
135Urethral obstruction (HP:0000796)1.64043223
136Capillary hemangiomas (HP:0005306)1.63543568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.00062811
2WEE14.87343263
3CDC74.45084724
4EIF2AK13.36509000
5BRSK23.19501089
6NEK23.02119882
7BMPR1B2.90537921
8TTK2.78120966
9NEK12.65729057
10SRPK12.63229049
11ACVR1B2.35468237
12PLK42.33739670
13PLK12.32483628
14EIF2AK32.18574095
15NME22.13240515
16VRK12.09002611
17CCNB12.03247587
18AURKB1.91951909
19BRSK11.90581606
20STK161.86495543
21MAP3K91.80732365
22TLK11.72860168
23ATR1.71429003
24CHEK21.65966118
25CDK71.65791526
26PLK31.61961315
27VRK21.61643188
28MKNK11.55322173
29TSSK61.53139143
30STK41.50331400
31ZAK1.47468898
32ARAF1.40742995
33DYRK31.35525461
34AURKA1.32540323
35STK241.31167058
36TESK21.29670647
37MAP3K131.28534272
38PBK1.24591290
39RPS6KA41.24419988
40MAP3K81.18651809
41CHEK11.17218708
42CDK41.16584438
43PASK1.13292300
44RPS6KB21.10712999
45MKNK21.09701920
46TAF11.05443787
47PNCK1.02611541
48EIF2AK20.99711999
49PDK40.97650427
50PDK30.97650427
51STK100.93029805
52CLK10.92103729
53CDK90.90020298
54ATM0.87740961
55PAK40.85529550
56TGFBR10.84547153
57STK38L0.79243726
58CDK20.76696331
59CDK80.76046773
60SCYL20.75669570
61TESK10.73142358
62PIM10.73061034
63BRAF0.71055511
64CDK120.69556716
65RAF10.69163002
66FLT30.67694513
67CSNK2A10.67280312
68CDK10.65029184
69MET0.61444431
70STK30.60446684
71CDK60.60006611
72MELK0.58337702
73CSNK2A20.58134094
74MOS0.57582379
75EPHA20.54515955
76PAK10.54437359
77BCKDK0.54058019
78CDK30.53842676
79MAPK110.53760799
80NEK60.52511533
81PIM20.52021400
82MAP3K110.50282516
83PDK20.49782456
84CAMK1G0.48453074
85TEC0.48447860
86TRPM70.47541884
87MTOR0.47153965
88NEK90.46014048
89NUAK10.43523609
90RPS6KA50.41799452
91BRD40.37372702
92KDR0.36683031
93PRKCI0.35860559
94ABL20.32734318
95MAPKAPK50.31711606
96LRRK20.31710443
97DMPK0.31576654
98ICK0.31546800
99MARK30.31431048
100MAP2K70.30631326
101MAPKAPK30.30627816
102MST40.30303647
103EEF2K0.29772452
104IRAK40.29393472
105BTK0.28842472
106PRKDC0.28679851
107MAP4K10.28637329
108AKT20.27704983
109TRIM280.27144186
110NME10.26299048
111YES10.25963581
112TAOK30.25791603
113CSF1R0.25774237
114ALK0.25379764
115DYRK20.22909882
116PKN20.21892541
117MAP3K100.20993437
118MAP2K30.20613449
119ERBB20.18797303
120CDK180.18130163
121CDK11A0.16334929
122CSNK1E0.16056785
123TAOK20.15765417
124KIT0.15373010

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.45022651
2Mismatch repair_Homo sapiens_hsa034304.64858475
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54335959
4Homologous recombination_Homo sapiens_hsa034403.54281512
5RNA polymerase_Homo sapiens_hsa030203.33256693
6Ribosome_Homo sapiens_hsa030103.29281960
7Spliceosome_Homo sapiens_hsa030403.21709967
8Base excision repair_Homo sapiens_hsa034103.17788483
9Proteasome_Homo sapiens_hsa030503.14410197
10Cell cycle_Homo sapiens_hsa041103.04387248
11RNA transport_Homo sapiens_hsa030132.98949044
12Nucleotide excision repair_Homo sapiens_hsa034202.97222820
13Fanconi anemia pathway_Homo sapiens_hsa034602.79380026
14Pyrimidine metabolism_Homo sapiens_hsa002402.72697789
15Non-homologous end-joining_Homo sapiens_hsa034502.26257150
16One carbon pool by folate_Homo sapiens_hsa006702.25109150
17Basal transcription factors_Homo sapiens_hsa030222.14360216
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03789721
19RNA degradation_Homo sapiens_hsa030181.96047267
20mRNA surveillance pathway_Homo sapiens_hsa030151.67668585
21p53 signaling pathway_Homo sapiens_hsa041151.62945316
22Purine metabolism_Homo sapiens_hsa002301.51036045
23Systemic lupus erythematosus_Homo sapiens_hsa053221.31242215
24Oocyte meiosis_Homo sapiens_hsa041141.22882251
25Epstein-Barr virus infection_Homo sapiens_hsa051691.16804787
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16367952
27Vitamin B6 metabolism_Homo sapiens_hsa007500.96158714
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94887176
29Herpes simplex infection_Homo sapiens_hsa051680.90358584
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86937918
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85945969
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84467180
33Huntingtons disease_Homo sapiens_hsa050160.82015416
34Protein export_Homo sapiens_hsa030600.81821518
35Viral carcinogenesis_Homo sapiens_hsa052030.81454645
36Pentose phosphate pathway_Homo sapiens_hsa000300.81142621
37Fatty acid elongation_Homo sapiens_hsa000620.77914349
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77506822
39Pyruvate metabolism_Homo sapiens_hsa006200.77446270
40Antigen processing and presentation_Homo sapiens_hsa046120.74551567
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.73563845
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.71645051
43Parkinsons disease_Homo sapiens_hsa050120.66392300
44Lysine degradation_Homo sapiens_hsa003100.65325768
45Biosynthesis of amino acids_Homo sapiens_hsa012300.63418713
46Folate biosynthesis_Homo sapiens_hsa007900.63166818
47HTLV-I infection_Homo sapiens_hsa051660.62453617
48Glutathione metabolism_Homo sapiens_hsa004800.60139582
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57786643
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56374725
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54554270
52MicroRNAs in cancer_Homo sapiens_hsa052060.51054316
53Selenocompound metabolism_Homo sapiens_hsa004500.50030596
54Small cell lung cancer_Homo sapiens_hsa052220.49533917
55Legionellosis_Homo sapiens_hsa051340.49170325
56N-Glycan biosynthesis_Homo sapiens_hsa005100.48210177
57Thyroid cancer_Homo sapiens_hsa052160.45376082
58Alcoholism_Homo sapiens_hsa050340.44537790
59Sulfur relay system_Homo sapiens_hsa041220.43743577
60Carbon metabolism_Homo sapiens_hsa012000.43259345
61Propanoate metabolism_Homo sapiens_hsa006400.43195152
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42967668
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41922677
64Oxidative phosphorylation_Homo sapiens_hsa001900.41152374
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.39737287
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36770313
67Apoptosis_Homo sapiens_hsa042100.36261129
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35295283
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34911137
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31786641
71Arachidonic acid metabolism_Homo sapiens_hsa005900.30773443
72TGF-beta signaling pathway_Homo sapiens_hsa043500.30333231
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29594473
74Metabolic pathways_Homo sapiens_hsa011000.28274153
75Basal cell carcinoma_Homo sapiens_hsa052170.27298211
76Primary immunodeficiency_Homo sapiens_hsa053400.26808991
77Measles_Homo sapiens_hsa051620.26741563
78Fructose and mannose metabolism_Homo sapiens_hsa000510.26421546
79Hepatitis B_Homo sapiens_hsa051610.25701055
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25024832
81Steroid biosynthesis_Homo sapiens_hsa001000.24554564
82Hippo signaling pathway_Homo sapiens_hsa043900.23888794
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.23855793
84Shigellosis_Homo sapiens_hsa051310.22519308
85Colorectal cancer_Homo sapiens_hsa052100.22510619
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20290603
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18311131
88Galactose metabolism_Homo sapiens_hsa000520.16461885
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16413366
90HIF-1 signaling pathway_Homo sapiens_hsa040660.16292176
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16078764
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15648290
93Hematopoietic cell lineage_Homo sapiens_hsa046400.15388690
94Pancreatic cancer_Homo sapiens_hsa052120.15098267
95Linoleic acid metabolism_Homo sapiens_hsa005910.15029897
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13737964
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13568305
98Pathways in cancer_Homo sapiens_hsa052000.13539257
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.13317128
100Influenza A_Homo sapiens_hsa051640.13245907
101Bladder cancer_Homo sapiens_hsa052190.11561507
102Circadian rhythm_Homo sapiens_hsa047100.11228280
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11164003
104Alzheimers disease_Homo sapiens_hsa050100.11136242
105Non-small cell lung cancer_Homo sapiens_hsa052230.10827429
106Sulfur metabolism_Homo sapiens_hsa009200.09247820
107Prostate cancer_Homo sapiens_hsa052150.09025318
108Hedgehog signaling pathway_Homo sapiens_hsa043400.08557519
109Renin-angiotensin system_Homo sapiens_hsa046140.08198039
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07294074
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07239629
112Chronic myeloid leukemia_Homo sapiens_hsa052200.07226322
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.05517792
114Ovarian steroidogenesis_Homo sapiens_hsa049130.05166859
115Inositol phosphate metabolism_Homo sapiens_hsa005620.04526224
116Arginine biosynthesis_Homo sapiens_hsa002200.03972179
117Wnt signaling pathway_Homo sapiens_hsa043100.03345674
118Cardiac muscle contraction_Homo sapiens_hsa042600.03336276
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02570606
120Phototransduction_Homo sapiens_hsa047440.01724818
121Regulation of autophagy_Homo sapiens_hsa041400.01211617
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00663571
123Notch signaling pathway_Homo sapiens_hsa043300.00355431
124Peroxisome_Homo sapiens_hsa04146-0.0529432
125Melanoma_Homo sapiens_hsa05218-0.0491448
126Olfactory transduction_Homo sapiens_hsa04740-0.0483298
127mTOR signaling pathway_Homo sapiens_hsa04150-0.0387462
128Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0237051

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