CENPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.28795157
2mannose metabolic process (GO:0006013)4.87408212
3mitotic metaphase plate congression (GO:0007080)4.52384125
4DNA replication initiation (GO:0006270)4.40652791
5DNA strand elongation involved in DNA replication (GO:0006271)4.38857780
6ribosomal small subunit assembly (GO:0000028)4.38705706
7protein localization to kinetochore (GO:0034501)4.29568612
8formation of translation preinitiation complex (GO:0001731)4.24600762
9telomere maintenance via semi-conservative replication (GO:0032201)4.23579585
10DNA strand elongation (GO:0022616)4.19607610
11maturation of SSU-rRNA (GO:0030490)4.18261776
12nucleobase biosynthetic process (GO:0046112)4.10258450
13DNA replication checkpoint (GO:0000076)4.05098722
14purine nucleobase biosynthetic process (GO:0009113)3.96404389
15metaphase plate congression (GO:0051310)3.93489172
16CENP-A containing nucleosome assembly (GO:0034080)3.90855885
17telomere maintenance via recombination (GO:0000722)3.90075612
18chromatin remodeling at centromere (GO:0031055)3.86164647
19DNA unwinding involved in DNA replication (GO:0006268)3.81098002
20ribosome biogenesis (GO:0042254)3.78671139
21mitotic sister chromatid segregation (GO:0000070)3.76498063
22mitotic recombination (GO:0006312)3.72261680
23DNA replication-dependent nucleosome assembly (GO:0006335)3.71611134
24DNA replication-dependent nucleosome organization (GO:0034723)3.71611134
25* kinetochore organization (GO:0051383)3.71590776
26mitotic nuclear envelope disassembly (GO:0007077)3.71391925
27histone H4 deacetylation (GO:0070933)3.70822051
28DNA deamination (GO:0045006)3.70025599
29protein retention in ER lumen (GO:0006621)3.67101820
30nuclear pore organization (GO:0006999)3.65069947
31protein localization to chromosome, centromeric region (GO:0071459)3.64584915
32attachment of spindle microtubules to kinetochore (GO:0008608)3.60915203
33ribonucleoprotein complex biogenesis (GO:0022613)3.59980122
34DNA replication-independent nucleosome organization (GO:0034724)3.57485316
35DNA replication-independent nucleosome assembly (GO:0006336)3.57485316
36poly(A)+ mRNA export from nucleus (GO:0016973)3.56673652
37telomere maintenance via telomere lengthening (GO:0010833)3.56527115
38IMP biosynthetic process (GO:0006188)3.55679699
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55192125
40establishment of chromosome localization (GO:0051303)3.54715473
41ribosomal small subunit biogenesis (GO:0042274)3.53171562
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51658597
43regulation of spindle organization (GO:0090224)3.51639087
44viral transcription (GO:0019083)3.49383373
45UV protection (GO:0009650)3.48787375
46regulation of ARF GTPase activity (GO:0032312)3.48759801
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.47293390
48* kinetochore assembly (GO:0051382)3.46434134
49spliceosomal snRNP assembly (GO:0000387)3.46417819
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45926847
51translational termination (GO:0006415)3.45607563
52nuclear envelope disassembly (GO:0051081)3.43233128
53membrane disassembly (GO:0030397)3.43233128
54COPI coating of Golgi vesicle (GO:0048205)3.41057121
55Golgi transport vesicle coating (GO:0048200)3.41057121
56platelet aggregation (GO:0070527)3.40710670
57mitotic chromosome condensation (GO:0007076)3.40473470
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.39832665
59histone H3 deacetylation (GO:0070932)3.39740710
60negative regulation of chromosome segregation (GO:0051985)3.37407223
61peptidyl-arginine omega-N-methylation (GO:0035247)3.33862189
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33660670
63ribosomal large subunit biogenesis (GO:0042273)3.33453112
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32566576
65negative regulation of sister chromatid segregation (GO:0033046)3.32566576
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.32566576
67negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32566576
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31129503
69proline biosynthetic process (GO:0006561)3.30839126
70sister chromatid segregation (GO:0000819)3.29122042
71rRNA processing (GO:0006364)3.27648669
72spindle assembly checkpoint (GO:0071173)3.25586911
73spindle checkpoint (GO:0031577)3.23322067
74ribosome assembly (GO:0042255)3.22674373
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22499771
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22273868
77translational initiation (GO:0006413)3.22085337
78mitotic spindle assembly checkpoint (GO:0007094)3.21642604
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.21269710
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.21269710
81translational elongation (GO:0006414)3.20674536
82histone exchange (GO:0043486)3.20395565
83nuclear pore complex assembly (GO:0051292)3.20046051
84meiotic chromosome segregation (GO:0045132)3.20009239
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.18186996
86transcription-coupled nucleotide-excision repair (GO:0006283)3.16957109
87rRNA metabolic process (GO:0016072)3.15929452
88viral mRNA export from host cell nucleus (GO:0046784)3.15863231
89regulation of chromosome segregation (GO:0051983)3.15654294
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15628995
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15415612
92maturation of 5.8S rRNA (GO:0000460)3.14750226
93positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.14059267
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13873071
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.13309679
96negative regulation of cell size (GO:0045792)3.11031804
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10705977
98mitotic spindle checkpoint (GO:0071174)3.09453963
99regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.08563747
100intracellular estrogen receptor signaling pathway (GO:0030520)3.08509108
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08060484
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.07864401
103regulation of sister chromatid segregation (GO:0033045)3.07295055
104regulation of mitotic sister chromatid separation (GO:0010965)3.07295055
105regulation of mitotic sister chromatid segregation (GO:0033047)3.07295055
106negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07010693
107negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06633568
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06407813
109spliceosomal complex assembly (GO:0000245)3.05485059
110dosage compensation (GO:0007549)3.04714683
111cullin deneddylation (GO:0010388)3.02584783
1123-UTR-mediated mRNA stabilization (GO:0070935)3.02433020
113regulation of nuclear cell cycle DNA replication (GO:0033262)3.02069878
114positive regulation of chromosome segregation (GO:0051984)3.02052086
115IMP metabolic process (GO:0046040)3.00277124
116pseudouridine synthesis (GO:0001522)2.98961021
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98448430
118regulation of mitotic spindle organization (GO:0060236)2.98286932
119telomere organization (GO:0032200)2.94586306
120telomere maintenance (GO:0000723)2.93976902
121stress fiber assembly (GO:0043149)2.93803211
122thymic T cell selection (GO:0045061)2.93734299
123G1/S transition of mitotic cell cycle (GO:0000082)2.92262988
124cell cycle G1/S phase transition (GO:0044843)2.92262988
125DNA duplex unwinding (GO:0032508)2.90595003
126regulation of centrosome cycle (GO:0046605)2.90212506
127modulation by virus of host process (GO:0019054)2.89586136
128DNA geometric change (GO:0032392)2.88811128
129protein K6-linked ubiquitination (GO:0085020)2.88800484
130response to muramyl dipeptide (GO:0032495)2.88450260
131megakaryocyte development (GO:0035855)2.88319318
132protein deneddylation (GO:0000338)2.88276624
133regulation of chromatin binding (GO:0035561)2.86217271
134protein insertion into membrane (GO:0051205)2.81829528
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81767487
136negative regulation of cell killing (GO:0031342)2.81767487
137extracellular fibril organization (GO:0043206)2.81724832
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.80597986
139regulation of integrin activation (GO:0033623)2.78609987
140protein-DNA complex disassembly (GO:0032986)2.76079438
141nucleosome disassembly (GO:0006337)2.76079438
142positive regulation of nuclease activity (GO:0032075)2.76074859
143platelet formation (GO:0030220)2.75450027
144protein maturation by protein folding (GO:0022417)2.75162606
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73824297
146protein targeting to plasma membrane (GO:0072661)2.72215081
147neutrophil activation involved in immune response (GO:0002283)2.71020023
148barbed-end actin filament capping (GO:0051016)2.70799827
149adherens junction assembly (GO:0034333)2.69952442
150activation of JUN kinase activity (GO:0007257)2.69245277
151fibril organization (GO:0097435)2.68266186
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.68188596
153negative thymic T cell selection (GO:0045060)2.68095081
154negative regulation of stress fiber assembly (GO:0051497)2.66675114
155pyrimidine nucleotide catabolic process (GO:0006244)2.66516091
156retrograde transport, endosome to Golgi (GO:0042147)2.66356960
157regulation of platelet aggregation (GO:0090330)2.65003546
158snRNA metabolic process (GO:0016073)2.64166881
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.63800327
160adenosine receptor signaling pathway (GO:0001973)2.63597699
161focal adhesion assembly (GO:0048041)2.63498016
162cell-substrate adherens junction assembly (GO:0007045)2.63498016
163regulation of histone H3-K27 methylation (GO:0061085)2.62647511
164homotypic cell-cell adhesion (GO:0034109)2.61703045
165GDP-mannose metabolic process (GO:0019673)2.61485119
166pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61156960
167positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60991316
168positive regulation of B cell differentiation (GO:0045579)2.59264944
169cellular response to interleukin-4 (GO:0071353)2.58923949
170nuclear envelope reassembly (GO:0031468)2.58365561
171mitotic nuclear envelope reassembly (GO:0007084)2.58365561
172regulation of monocyte differentiation (GO:0045655)2.57588088
173lipoxygenase pathway (GO:0019372)2.56497755
174positive regulation of protein dephosphorylation (GO:0035307)2.56278531
175positive regulation of granulocyte differentiation (GO:0030854)2.55866692
176positive regulation of synapse maturation (GO:0090129)2.55391414
177pinocytosis (GO:0006907)2.50747265
178pentose-phosphate shunt (GO:0006098)2.50424521
179peptidyl-arginine methylation (GO:0018216)2.50162763
180peptidyl-arginine N-methylation (GO:0035246)2.50162763
181protein kinase C signaling (GO:0070528)2.49549352
182negative regulation of histone methylation (GO:0031061)2.48185306
183negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.47748610
184negative T cell selection (GO:0043383)2.46416551
185regulation of leukocyte degranulation (GO:0043300)2.46246957
186spliceosomal tri-snRNP complex assembly (GO:0000244)2.45917400
187actin nucleation (GO:0045010)2.45254825
188regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45245051
189positive regulation of gamma-delta T cell activation (GO:0046645)2.43177660
190regulation of T-helper 2 cell differentiation (GO:0045628)2.42079457
191negative regulation of microtubule polymerization (GO:0031115)2.41356619
192actin filament polymerization (GO:0030041)2.40724678
193signal complex assembly (GO:0007172)2.40623529
194response to interleukin-4 (GO:0070670)2.38724898
195modulation by symbiont of host cellular process (GO:0044068)2.37526948
196regulation of nuclease activity (GO:0032069)2.36959990
197phosphatidylglycerol biosynthetic process (GO:0006655)2.36748866
198negative regulation of smooth muscle cell migration (GO:0014912)2.36615304
199regulation of defense response to virus by virus (GO:0050690)2.35800740
200positive regulation of receptor recycling (GO:0001921)2.35372740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12563058
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.36826884
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.17930915
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60968603
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42222640
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22104610
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17362221
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05079088
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.98588476
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.98371333
11VDR_21846776_ChIP-Seq_THP-1_Human2.93892223
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90990670
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87681764
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81583254
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.75681121
16LXR_22292898_ChIP-Seq_THP-1_Human2.75609182
17* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66677137
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.66229281
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53479955
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.53066177
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48231852
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45186944
23XRN2_22483619_ChIP-Seq_HELA_Human2.35720076
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35590501
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34759861
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.30972177
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24784727
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23938017
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18833093
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17632573
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14831534
32VDR_23849224_ChIP-Seq_CD4+_Human2.11838467
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11621887
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05910796
35KDM2B_26808549_Chip-Seq_DND41_Human2.03365105
36TCF7_22412390_ChIP-Seq_EML_Mouse1.97893901
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.97680127
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94021816
39* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93433573
40P68_20966046_ChIP-Seq_HELA_Human1.92844048
41FOXP3_21729870_ChIP-Seq_TREG_Human1.92731403
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87907617
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87850486
44DCP1A_22483619_ChIP-Seq_HELA_Human1.87811197
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86993408
46TTF2_22483619_ChIP-Seq_HELA_Human1.86722304
47AR_21909140_ChIP-Seq_LNCAP_Human1.85899477
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85403622
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84819633
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.83588026
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82466297
52* GABP_19822575_ChIP-Seq_HepG2_Human1.82384483
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80393187
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.78727748
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77746940
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.76688338
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74093647
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73088656
59* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72625755
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.71866956
61RACK7_27058665_Chip-Seq_MCF-7_Human1.71589931
62UTX_26944678_Chip-Seq_JUKART_Human1.70945222
63CIITA_25753668_ChIP-Seq_RAJI_Human1.69855413
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.69839589
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68940637
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.67962472
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64124016
68MAF_26560356_Chip-Seq_TH2_Human1.62777298
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61869363
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60354169
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59522864
72MAF_26560356_Chip-Seq_TH1_Human1.59283930
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58945673
74ELK1_19687146_ChIP-ChIP_HELA_Human1.58204772
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57603408
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.56949067
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55893271
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55733416
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55448811
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54795598
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.54557171
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.54271753
83VDR_24763502_ChIP-Seq_THP-1_Human1.51962637
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50701521
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50238334
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49887587
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48322782
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48278425
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47122660
90* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46262150
91BCL6_27268052_Chip-Seq_Bcells_Human1.46134146
92BCOR_27268052_Chip-Seq_Bcells_Human1.46106876
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46070479
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44625198
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44365188
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43342506
97* NCOR1_26117541_ChIP-Seq_K562_Human1.43080632
98SMC4_20622854_ChIP-Seq_HELA_Human1.42274970
99KDM2B_26808549_Chip-Seq_K562_Human1.41835828
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41239459
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.40697588
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.40697588
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.40697588
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40409151
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39652529
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.39567956
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.39543421
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39296523
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37896454
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37536405
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35732726
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35298355
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.35280793
114SCL_19346495_ChIP-Seq_HPC-7_Human1.33872591
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32214533
116MYC_22102868_ChIP-Seq_BL_Human1.31493803
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.30547417
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.30389377
119KDM5A_27292631_Chip-Seq_BREAST_Human1.29596780
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28345416
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26670610
122CREB1_26743006_Chip-Seq_LNCaP_Human1.25796155
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23610596
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21944538
125* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21776984
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21316693
127TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20763330
128IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20616324
129PHF8_20622854_ChIP-Seq_HELA_Human1.19843823
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18852685
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18666839
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18194928
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17360400
134CTCF_26484167_Chip-Seq_Bcells_Mouse1.15208993
135CTCF_27219007_Chip-Seq_Bcells_Human1.14680490
136BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14168962
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13538366
138CTCF_21964334_Chip-Seq_Bcells_Human1.13512645
139ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13367435
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12625363
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12377030
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11845235
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10104058
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09965235
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09879385
146E2F1_20622854_ChIP-Seq_HELA_Human1.08815146
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07308281
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06815148
149GATA1_19941826_ChIP-Seq_K562_Human1.06809113
150CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06796493
151MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06433258
152ZNF263_19887448_ChIP-Seq_K562_Human1.06234228
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06106766
154TFEB_21752829_ChIP-Seq_HELA_Human1.06031629
155GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05990621
156CLOCK_20551151_ChIP-Seq_293T_Human1.05897239
157* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05759634
158NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04647017
159HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04553979
160P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04209248
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04194067
162NANOG_21062744_ChIP-ChIP_HESCs_Human1.03351246
163PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03075044
164SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02526014
165TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02508289
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02438002
167ETS1_21867929_ChIP-Seq_TH2_Mouse1.01977200
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00482449
169CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99804296
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98337387
171SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98215016
172PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98075790
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94685215
174TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93780715
175OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93549970
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93186511
177SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92120403
178NOTCH1_21737748_ChIP-Seq_TLL_Human0.91978976
179CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88516301
180CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87995156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.19758799
2MP0010094_abnormal_chromosome_stability4.46068309
3MP0003111_abnormal_nucleus_morphology4.43519919
4MP0004957_abnormal_blastocyst_morpholog4.42032491
5MP0003077_abnormal_cell_cycle4.03666661
6MP0008057_abnormal_DNA_replication3.94022442
7MP0003705_abnormal_hypodermis_morpholog3.66227604
8MP0005464_abnormal_platelet_physiology3.54295164
9MP0008058_abnormal_DNA_repair3.49387865
10MP0005058_abnormal_lysosome_morphology3.45655959
11MP0008260_abnormal_autophagy3.26592695
12MP0008007_abnormal_cellular_replicative3.15533437
13MP0003436_decreased_susceptibility_to3.03673142
14MP0003172_abnormal_lysosome_physiology2.99307784
15MP0003123_paternal_imprinting2.73494811
16MP0008932_abnormal_embryonic_tissue2.71112062
17MP0009278_abnormal_bone_marrow2.68038104
18MP0008438_abnormal_cutaneous_collagen2.51153654
19MP0001730_embryonic_growth_arrest2.27566570
20MP0004859_abnormal_synaptic_plasticity2.26285172
21MP0000350_abnormal_cell_proliferation2.23981104
22MP0010030_abnormal_orbit_morphology2.19065959
23MP0003786_premature_aging2.18504493
24MP0008877_abnormal_DNA_methylation2.10337711
25MP0002396_abnormal_hematopoietic_system2.01656047
26MP0010352_gastrointestinal_tract_polyps1.98565278
27MP0005451_abnormal_body_composition1.97801492
28MP0003121_genomic_imprinting1.94398875
29MP0000465_gastrointestinal_hemorrhage1.94181447
30MP0006292_abnormal_olfactory_placode1.93612266
31MP0000003_abnormal_adipose_tissue1.89271491
32MP0003303_peritoneal_inflammation1.83272982
33MP0009384_cardiac_valve_regurgitation1.82189988
34MP0001672_abnormal_embryogenesis/_devel1.80618474
35MP0005380_embryogenesis_phenotype1.80618474
36MP0001697_abnormal_embryo_size1.78174672
37MP0003279_aneurysm1.77965498
38MP0004947_skin_inflammation1.75087916
39MP0003315_abnormal_perineum_morphology1.72428091
40MP0001958_emphysema1.72317305
41MP0001348_abnormal_lacrimal_gland1.69808516
42MP0002085_abnormal_embryonic_tissue1.65725688
43MP0000490_abnormal_crypts_of1.65586680
44MP0002822_catalepsy1.64694126
45MP0002080_prenatal_lethality1.58882874
46MP0003984_embryonic_growth_retardation1.58823610
47MP0010307_abnormal_tumor_latency1.58316019
48MP0002084_abnormal_developmental_patter1.56447052
49MP0003718_maternal_effect1.55375321
50MP0002088_abnormal_embryonic_growth/wei1.54462077
51MP0004185_abnormal_adipocyte_glucose1.48972885
52MP0005666_abnormal_adipose_tissue1.48221085
53MP0003567_abnormal_fetal_cardiomyocyte1.48079739
54MP0002086_abnormal_extraembryonic_tissu1.47789371
55MP0005375_adipose_tissue_phenotype1.47432859
56MP0002653_abnormal_ependyma_morphology1.47390148
57MP0004133_heterotaxia1.46344172
58MP0004808_abnormal_hematopoietic_stem1.45518125
59MP0004197_abnormal_fetal_growth/weight/1.45474496
60MP0001293_anophthalmia1.45430165
61MP0003941_abnormal_skin_development1.43462685
62MP0003656_abnormal_erythrocyte_physiolo1.42938423
63MP0000313_abnormal_cell_death1.42888213
64MP0005501_abnormal_skin_physiology1.42856719
65MP0000013_abnormal_adipose_tissue1.38847905
66MP0003890_abnormal_embryonic-extraembry1.37261829
67MP0002210_abnormal_sex_determination1.34713973
68MP0001851_eye_inflammation1.33930977
69MP0000751_myopathy1.32732194
70MP0003191_abnormal_cellular_cholesterol1.32455825
71MP0000678_abnormal_parathyroid_gland1.25011420
72MP0004858_abnormal_nervous_system1.21962727
73MP0002019_abnormal_tumor_incidence1.21928001
74MP0003329_amyloid_beta_deposits1.21112198
75MP0009840_abnormal_foam_cell1.19725405
76MP0003119_abnormal_digestive_system1.18587061
77MP0001533_abnormal_skeleton_physiology1.17801619
78MP0003806_abnormal_nucleotide_metabolis1.17431229
79MP0001145_abnormal_male_reproductive1.14208244
80MP0005000_abnormal_immune_tolerance1.11644260
81MP0005275_abnormal_skin_tensile1.07328887
82MP0009053_abnormal_anal_canal1.06623742
83MP0003300_gastrointestinal_ulcer1.05597784
84MP0005409_darkened_coat_color1.04562468
85MP0005025_abnormal_response_to1.03944554
86MP0004510_myositis1.03401456
87MP0009931_abnormal_skin_appearance1.02771217
88MP0000716_abnormal_immune_system1.01840203
89MP0002796_impaired_skin_barrier1.01505285
90MP0002160_abnormal_reproductive_system1.01333094
91MP0009333_abnormal_splenocyte_physiolog0.99987549
92MP0002420_abnormal_adaptive_immunity0.97927682
93MP0001819_abnormal_immune_cell0.97141992
94MP0005397_hematopoietic_system_phenotyp0.96581018
95MP0001545_abnormal_hematopoietic_system0.96581018
96MP0003091_abnormal_cell_migration0.96431186
97MP0008569_lethality_at_weaning0.96303952
98MP0001929_abnormal_gametogenesis0.96144719
99MP0000653_abnormal_sex_gland0.94867092
100MP0000681_abnormal_thyroid_gland0.93482977
101MP0001849_ear_inflammation0.93397956
102MP0003453_abnormal_keratinocyte_physiol0.92922712
103MP0005670_abnormal_white_adipose0.92755405
104MP0002970_abnormal_white_adipose0.92469451
105MP0002419_abnormal_innate_immunity0.91475106
106MP0001873_stomach_inflammation0.91138116
107MP0001853_heart_inflammation0.91135314
108MP0001243_abnormal_dermal_layer0.90599086
109MP0008874_decreased_physiological_sensi0.90294356
110MP0001119_abnormal_female_reproductive0.90140781
111MP0002933_joint_inflammation0.89681842
112MP0002938_white_spotting0.88222242
113MP0005083_abnormal_biliary_tract0.86902047
114MP0001800_abnormal_humoral_immune0.86872296
115MP0000537_abnormal_urethra_morphology0.85810171
116MP0005389_reproductive_system_phenotype0.85753111
117MP0002723_abnormal_immune_serum0.85576151
118MP0002060_abnormal_skin_morphology0.85573431
119MP0003787_abnormal_imprinting0.84926333
120MP0000467_abnormal_esophagus_morphology0.84563901
121MP0000703_abnormal_thymus_morphology0.84563695
122MP0005390_skeleton_phenotype0.84536413
123MP0008995_early_reproductive_senescence0.81696270
124MP0002405_respiratory_system_inflammati0.81090055
125MP0002111_abnormal_tail_morphology0.80987942
126MP0001835_abnormal_antigen_presentation0.80434821
127MP0005076_abnormal_cell_differentiation0.79402563
128MP0005384_cellular_phenotype0.78964015
129MP0004272_abnormal_basement_membrane0.78795381
130MP0002398_abnormal_bone_marrow0.78440652
131MP0001286_abnormal_eye_development0.77469132
132MP0006138_congestive_heart_failure0.75621752
133MP0002877_abnormal_melanocyte_morpholog0.75484737
134MP0000049_abnormal_middle_ear0.75396223
135MP0008789_abnormal_olfactory_epithelium0.75332224
136MP0000358_abnormal_cell_content/0.75011142
137MP0002089_abnormal_postnatal_growth/wei0.74655058
138MP0002132_abnormal_respiratory_system0.73582128
139MP0002722_abnormal_immune_system0.73329557
140MP0003937_abnormal_limbs/digits/tail_de0.73216305
141MP0000767_abnormal_smooth_muscle0.73188383
142MP0001270_distended_abdomen0.72830269
143MP0002998_abnormal_bone_remodeling0.72417822
144MP0005503_abnormal_tendon_morphology0.71882583
145MP0008004_abnormal_stomach_pH0.71607995
146MP0005621_abnormal_cell_physiology0.70470375
147MP0009697_abnormal_copulation0.70433035
148MP0009379_abnormal_foot_pigmentation0.70339812
149MP0003861_abnormal_nervous_system0.69909472
150MP0002751_abnormal_autonomic_nervous0.69697545
151MP0000689_abnormal_spleen_morphology0.68276061
152MP0003122_maternal_imprinting0.68207237
153MP0003763_abnormal_thymus_physiology0.67358890
154MP0003943_abnormal_hepatobiliary_system0.66391411
155MP0003755_abnormal_palate_morphology0.66090533
156MP0005367_renal/urinary_system_phenotyp0.65523451
157MP0000516_abnormal_urinary_system0.65523451
158MP0002249_abnormal_larynx_morphology0.65344725
159MP0002075_abnormal_coat/hair_pigmentati0.64303499
160MP0002114_abnormal_axial_skeleton0.64065733
161MP0001919_abnormal_reproductive_system0.62751199
162MP0005023_abnormal_wound_healing0.62679790
163MP0002095_abnormal_skin_pigmentation0.62183946
164MP0001915_intracranial_hemorrhage0.61454049
165MP0000858_altered_metastatic_potential0.60964106
166MP0000432_abnormal_head_morphology0.60795156
167MP0009672_abnormal_birth_weight0.60669458
168MP0005075_abnormal_melanosome_morpholog0.60405393
169MP0005174_abnormal_tail_pigmentation0.59955512
170MP0002932_abnormal_joint_morphology0.59869067
171MP0002092_abnormal_eye_morphology0.59482897
172MP0003935_abnormal_craniofacial_develop0.59463519
173MP0003566_abnormal_cell_adhesion0.58689945
174MP0000428_abnormal_craniofacial_morphol0.58653281
175MP0002429_abnormal_blood_cell0.58574017

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.20581079
2Prolonged bleeding time (HP:0003010)4.47745492
3Breast hypoplasia (HP:0003187)4.12556540
4Menorrhagia (HP:0000132)3.94680470
5Abnormality of the labia minora (HP:0012880)3.84427791
6Cholecystitis (HP:0001082)3.78135240
7Abnormal gallbladder physiology (HP:0012438)3.78135240
8Reticulocytopenia (HP:0001896)3.77194884
9Patellar aplasia (HP:0006443)3.67844039
10Selective tooth agenesis (HP:0001592)3.67392340
11Degeneration of anterior horn cells (HP:0002398)3.61428928
12Abnormality of the anterior horn cell (HP:0006802)3.61428928
13Colon cancer (HP:0003003)3.54024341
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51342743
15Chromsome breakage (HP:0040012)3.50426472
16Oral leukoplakia (HP:0002745)3.48191382
17Aplasia/Hypoplasia of the patella (HP:0006498)3.44351888
18Petechiae (HP:0000967)3.36933692
19Purpura (HP:0000979)3.32508098
20Epistaxis (HP:0000421)3.30988331
21Carpal bone hypoplasia (HP:0001498)3.29690820
22Ependymoma (HP:0002888)3.25520690
23Protrusio acetabuli (HP:0003179)3.19593067
24Abnormal platelet volume (HP:0011876)3.19022967
25Biconcave vertebral bodies (HP:0004586)3.18895530
26Medulloblastoma (HP:0002885)3.17620153
27Distal lower limb amyotrophy (HP:0008944)3.16443671
28Meckel diverticulum (HP:0002245)3.12439317
29Abnormality of cells of the erythroid lineage (HP:0012130)3.12401591
30Increased mean platelet volume (HP:0011877)3.09876107
31Rough bone trabeculation (HP:0100670)3.07611995
32Abnormality of the ileum (HP:0001549)3.05482200
33Obstructive sleep apnea (HP:0002870)3.05358756
34Impulsivity (HP:0100710)3.03469051
35Abnormality of the preputium (HP:0100587)3.01091688
36Reticulocytosis (HP:0001923)2.98702576
37Distal upper limb amyotrophy (HP:0007149)2.98159093
38Upper limb amyotrophy (HP:0009129)2.98159093
39Abnormal number of erythroid precursors (HP:0012131)2.97933476
40Broad face (HP:0000283)2.96733267
41Abnormality of chromosome stability (HP:0003220)2.90017060
42Cerebral aneurysm (HP:0004944)2.86529347
43Absent thumb (HP:0009777)2.85184621
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.83642507
45Supernumerary spleens (HP:0009799)2.80198472
46Absent radius (HP:0003974)2.77504877
47Myelodysplasia (HP:0002863)2.73615004
48Premature rupture of membranes (HP:0001788)2.72600297
4911 pairs of ribs (HP:0000878)2.68637471
50Premature graying of hair (HP:0002216)2.67426213
51Small intestinal stenosis (HP:0012848)2.67072567
52Duodenal stenosis (HP:0100867)2.67072567
53Cerebral hypomyelination (HP:0006808)2.67071059
54Agnosia (HP:0010524)2.63357579
55Aplastic anemia (HP:0001915)2.61849398
56Increased IgE level (HP:0003212)2.59408156
57Absent forearm bone (HP:0003953)2.57343771
58Aplasia involving forearm bones (HP:0009822)2.57343771
59Cervical subluxation (HP:0003308)2.57124564
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56597918
61Abnormal number of incisors (HP:0011064)2.55283296
62Bone marrow hypocellularity (HP:0005528)2.53630948
63Rhabdomyosarcoma (HP:0002859)2.51492839
64Abnormality of the Achilles tendon (HP:0005109)2.48488915
65Abnormal lung lobation (HP:0002101)2.48398036
66Eczematoid dermatitis (HP:0000976)2.46886732
67Cellulitis (HP:0100658)2.46616409
68Impaired platelet aggregation (HP:0003540)2.46310921
69Abnormal platelet function (HP:0011869)2.46310921
70Ankle clonus (HP:0011448)2.39836665
71Difficulty climbing stairs (HP:0003551)2.39807223
72Achilles tendon contracture (HP:0001771)2.37725478
73Hyperacusis (HP:0010780)2.37402499
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.35315112
75Lower limb amyotrophy (HP:0007210)2.33812230
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.33586970
77Tracheoesophageal fistula (HP:0002575)2.33210539
78Hand muscle atrophy (HP:0009130)2.30872024
79Neoplasm of the pancreas (HP:0002894)2.30527533
80Nephroblastoma (Wilms tumor) (HP:0002667)2.30249215
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.29508594
82Abnormality of lateral ventricle (HP:0030047)2.29135544
83Sloping forehead (HP:0000340)2.29081080
84Triphalangeal thumb (HP:0001199)2.28939677
85Horseshoe kidney (HP:0000085)2.28672143
86Abnormal trabecular bone morphology (HP:0100671)2.27210869
87Abnormality of the duodenum (HP:0002246)2.26889778
88Astrocytoma (HP:0009592)2.26289823
89Abnormality of the astrocytes (HP:0100707)2.26289823
90Facial hemangioma (HP:0000329)2.25872483
91Pallor (HP:0000980)2.24934400
92Disproportionate tall stature (HP:0001519)2.23411011
93Proximal placement of thumb (HP:0009623)2.23384525
94Hypertriglyceridemia (HP:0002155)2.23284373
95Stridor (HP:0010307)2.23037523
96Hepatosplenomegaly (HP:0001433)2.22949302
97Atresia of the external auditory canal (HP:0000413)2.22297701
98Deviation of the thumb (HP:0009603)2.20579652
99Trismus (HP:0000211)2.20148791
100Myopathic facies (HP:0002058)2.19914887
101Dysostosis multiplex (HP:0000943)2.18553127
102Hypertensive crisis (HP:0100735)2.16832547
103Ectopic kidney (HP:0000086)2.16762789
104Cellular immunodeficiency (HP:0005374)2.15428254
105Pointed chin (HP:0000307)2.14379192
106Macrocytic anemia (HP:0001972)2.14303231
107Joint stiffness (HP:0001387)2.13314440
108Embryonal renal neoplasm (HP:0011794)2.13223133
109Aplasia/hypoplasia of the humerus (HP:0006507)2.12332520
110Growth hormone excess (HP:0000845)2.11919627
111Glioma (HP:0009733)2.11717377
112Hemorrhage of the eye (HP:0011885)2.11620392
113J-shaped sella turcica (HP:0002680)2.10718446
114Rib fusion (HP:0000902)2.10693930
115Amaurosis fugax (HP:0100576)2.10684414
116Gingival bleeding (HP:0000225)2.08866275
117Easy fatigability (HP:0003388)2.08450839
118Obstructive lung disease (HP:0006536)2.07595640
119Chronic obstructive pulmonary disease (HP:0006510)2.07595640
120Supranuclear gaze palsy (HP:0000605)2.07516739
121Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06272329
122Gastrointestinal inflammation (HP:0004386)2.06128052
123Broad distal phalanx of finger (HP:0009836)2.06016032
124Increased connective tissue (HP:0009025)2.05731753
125Colitis (HP:0002583)2.03534240
126Seborrheic dermatitis (HP:0001051)2.03274997
127Gastrointestinal dysmotility (HP:0002579)2.02584075
128Short thumb (HP:0009778)2.02263512
129Emphysema (HP:0002097)2.02074588
130Increased variability in muscle fiber diameter (HP:0003557)2.02001368
131Missing ribs (HP:0000921)2.01431643
132Neuronal loss in central nervous system (HP:0002529)2.01395541
133Basal cell carcinoma (HP:0002671)2.00102201
134Fragile skin (HP:0001030)1.98872194
135Shawl scrotum (HP:0000049)1.98699258
136Annular pancreas (HP:0001734)1.97578348
137Cleft eyelid (HP:0000625)1.96232548
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.95244145
139Thrombocytosis (HP:0001894)1.94605878
140Premature ovarian failure (HP:0008209)1.94303270
141Insomnia (HP:0100785)1.94146982
142Thin bony cortex (HP:0002753)1.93292785
143Rectovaginal fistula (HP:0000143)1.92439293
144Rectal fistula (HP:0100590)1.92439293
145Vertebral compression fractures (HP:0002953)1.91977513
146Tongue fasciculations (HP:0001308)1.89687061
147Atrophic scars (HP:0001075)1.89550618
148Bruising susceptibility (HP:0000978)1.89087004
149Spinal rigidity (HP:0003306)1.88086971
150Spinal canal stenosis (HP:0003416)1.87737147
151Ulnar bowing (HP:0003031)1.87207747
152Ragged-red muscle fibers (HP:0003200)1.87112780
153Polycythemia (HP:0001901)1.86097448
154Abnormality of reticulocytes (HP:0004312)1.84968063
155Abnormality of skeletal muscle fiber size (HP:0012084)1.84237116
156Shallow orbits (HP:0000586)1.83542400
157Neoplasm of the oral cavity (HP:0100649)1.83532568
158Optic nerve coloboma (HP:0000588)1.83424855
159Squamous cell carcinoma (HP:0002860)1.82857526
160Blue sclerae (HP:0000592)1.82659443
161Neoplasm of striated muscle (HP:0009728)1.82495730
162Truncus arteriosus (HP:0001660)1.81944257
163Microretrognathia (HP:0000308)1.81799530
164Abdominal situs inversus (HP:0003363)1.81766174
165Abnormality of abdominal situs (HP:0011620)1.81766174
166Glossoptosis (HP:0000162)1.81080627
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79908354
168Atelectasis (HP:0100750)1.79672153
169Dilatation of the ascending aorta (HP:0005111)1.79220750
170Increased serum ferritin (HP:0003281)1.78464720
171Increased nuchal translucency (HP:0010880)1.77502643
172High anterior hairline (HP:0009890)1.76973480
173Metaphyseal cupping (HP:0003021)1.76852374
174Mitral regurgitation (HP:0001653)1.76360211
175Abnormality of the carotid arteries (HP:0005344)1.75253919
176Cholelithiasis (HP:0001081)1.74947995
177Facial cleft (HP:0002006)1.74861208
178Short humerus (HP:0005792)1.74389709
179Premature skin wrinkling (HP:0100678)1.74086488
180Agammaglobulinemia (HP:0004432)1.73475423
181Cafe-au-lait spot (HP:0000957)1.72690715
182Clubbing of toes (HP:0100760)1.71856917
183Spinal muscular atrophy (HP:0007269)1.71339733
184Hypoplasia of the radius (HP:0002984)1.71292701
185Intestinal fistula (HP:0100819)1.70747487
186Duplicated collecting system (HP:0000081)1.70523454
187Distal lower limb muscle weakness (HP:0009053)1.70469089
188Nonimmune hydrops fetalis (HP:0001790)1.68368381
189Inflammation of the large intestine (HP:0002037)1.66272489
190Hypercortisolism (HP:0001578)1.64553355
191Polygenic inheritance (HP:0010982)1.63055946
192Cerebral palsy (HP:0100021)1.62823876
193Papilledema (HP:0001085)1.62810991
194Progressive external ophthalmoplegia (HP:0000590)1.62662244
195Progressive muscle weakness (HP:0003323)1.62158227
196Hammertoe (HP:0001765)1.61368365
197Hyperlipoproteinemia (HP:0010980)1.60567943
198Granulocytopenia (HP:0001913)1.59162659
199Broad palm (HP:0001169)1.57629836
200Thin ribs (HP:0000883)1.57472654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.12222079
2WEE14.76161751
3TRIB33.70936670
4ERN13.59593118
5CDC73.50185724
6EIF2AK13.24563142
7PRPF4B2.74944419
8NEK22.71563382
9BRSK22.61071900
10RIPK42.57512804
11SRPK12.57474267
12SMG12.49239569
13ACVR1B2.47950408
14NEK12.44637852
15TSSK62.36471896
16SIK12.33365132
17TTK2.27291936
18PLK12.24335561
19PLK42.22321384
20CDK122.05958028
21MKNK12.00977997
22SIK21.97874496
23NME21.95663286
24STK161.94489324
25EPHA21.91658950
26CDK71.90239062
27VRK11.88985890
28PLK31.83933908
29RPS6KB21.81305693
30ICK1.79101312
31MAP3K131.70672395
32AURKB1.69447234
33BRSK11.68902679
34ATR1.68764274
35MAP3K61.66533279
36FGFR41.64919934
37CHEK21.64707440
38DYRK31.64514197
39BMX1.62819105
40TNK21.58302883
41GRK61.57603512
42TGFBR11.52733249
43CCNB11.47924209
44PKN21.45571170
45EIF2AK31.45164499
46PASK1.42498840
47AURKA1.39031040
48MKNK21.34937828
49TESK21.33760474
50MARK21.32312678
51ZAP701.30423559
52TLK11.27988106
53PRKD21.26665524
54RIPK11.25462177
55CHEK11.22759552
56CDK81.22368938
57PAK41.21078915
58AKT31.15556283
59MAP2K61.12288741
60EPHB11.09801507
61BTK1.07380316
62CDK41.05950302
63PDGFRA1.05934828
64MAP3K81.05509735
65TBK11.05026053
66DYRK21.04305733
67EEF2K1.03749351
68ZAK1.00411460
69RPS6KA41.00016288
70MAP3K70.98360180
71CDC42BPA0.96845132
72FES0.96756616
73TYK20.93564470
74PRKD30.91919013
75ARAF0.90948903
76JAK30.90869747
77CDK20.89798173
78DYRK1B0.86662637
79BRD40.86088090
80MAPK120.83358098
81ATM0.83115127
82NTRK10.81562202
83MAP3K10.80760511
84STK100.80675273
85TTN0.80419165
86PRKCI0.80083717
87PIM10.79680326
88STK40.77857364
89UHMK10.77482473
90EIF2AK20.77412567
91RPS6KA20.75828262
92PAK10.74464088
93MAPKAPK30.74340213
94MAP3K30.74156846
95PNCK0.73882990
96KSR20.73677740
97RET0.72171942
98PDPK10.71529661
99CSNK2A10.70710155
100TYRO30.69375004
101RPS6KL10.68353175
102RPS6KC10.68353175
103CDK10.68257759
104PAK60.68072689
105STK38L0.67952372
106DAPK10.67825861
107CSNK2A20.66870480
108CAMKK10.66300785
109BRAF0.66116324
110MAPK110.65277814
111VRK20.64004034
112ALK0.63164519
113SYK0.61761361
114HCK0.58572048
115LATS20.58472931
116TESK10.58157725
117IRAK30.56755768
118TAOK10.55715137
119DDR20.54553833
120YES10.54170960
121CDK90.53770161
122ERBB30.53424437
123PDK10.52724922
124PTK60.52618332
125HIPK20.52265247
126BLK0.51835964
127PAK20.51543532
128STK380.50425200
129RAF10.49782459
130BCKDK0.49608130
131MAP3K140.49304180
132PRKD10.49018438
133SIK30.47390208
134KDR0.46565475
135FGR0.46397821
136CSF1R0.46118716
137MELK0.45141633
138MAP2K20.44024801
139MAPK100.43997294
140DAPK30.43750095
141RPS6KA60.43168568
142CDK140.42381777
143PTK20.41214169
144NME10.40828372
145MAPK70.40142910
146AKT20.39245844
147FLT30.38107261
148TAOK20.37754557
149MARK30.36556501
150RPS6KA50.33601833
151MAP3K100.33173795
152PIM20.31808366
153LIMK10.30166205
154CDK60.29481576
155MAP4K10.27182951
156MAP3K110.26648143
157ILK0.26490252
158MATK0.26192186
159PRKDC0.25741150
160CDK180.25402710
161CDK11A0.25306744
162CSNK1E0.25283291
163MTOR0.24926916
164CHUK0.24831750
165MAPK140.24704824
166PBK0.24168409
167KSR10.23566083
168SCYL20.23414625
169LRRK20.22853128
170BCR0.22460664
171CLK10.22436251
172CDK150.20753071
173MAPK10.20231380
174AKT10.19910224
175MAP2K30.19756964

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79728205
2Mismatch repair_Homo sapiens_hsa034304.37045804
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.75662324
4Ribosome_Homo sapiens_hsa030103.56307314
5RNA polymerase_Homo sapiens_hsa030203.41985249
6Spliceosome_Homo sapiens_hsa030403.41543569
7Proteasome_Homo sapiens_hsa030503.39800387
8Other glycan degradation_Homo sapiens_hsa005113.28326895
9Base excision repair_Homo sapiens_hsa034103.28122074
10RNA transport_Homo sapiens_hsa030133.17793008
11Homologous recombination_Homo sapiens_hsa034403.04247051
12Nucleotide excision repair_Homo sapiens_hsa034202.99385396
13Cell cycle_Homo sapiens_hsa041102.90560885
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52045486
15Pyrimidine metabolism_Homo sapiens_hsa002402.47049423
16Fanconi anemia pathway_Homo sapiens_hsa034602.33022923
17Acute myeloid leukemia_Homo sapiens_hsa052212.28870924
18One carbon pool by folate_Homo sapiens_hsa006702.19288683
19Basal transcription factors_Homo sapiens_hsa030222.10605860
20RNA degradation_Homo sapiens_hsa030182.06564705
21Non-homologous end-joining_Homo sapiens_hsa034501.99037636
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.97791676
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.82624087
24mRNA surveillance pathway_Homo sapiens_hsa030151.80949144
25Platelet activation_Homo sapiens_hsa046111.75034673
26p53 signaling pathway_Homo sapiens_hsa041151.74779699
27VEGF signaling pathway_Homo sapiens_hsa043701.71493441
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69160058
29Non-small cell lung cancer_Homo sapiens_hsa052231.55334715
30Synaptic vesicle cycle_Homo sapiens_hsa047211.54207218
31B cell receptor signaling pathway_Homo sapiens_hsa046621.47837995
32Endocytosis_Homo sapiens_hsa041441.39386749
33Purine metabolism_Homo sapiens_hsa002301.37731087
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34571525
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.32056046
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.29467434
37Pancreatic cancer_Homo sapiens_hsa052121.27338738
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27016379
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23929907
40Epstein-Barr virus infection_Homo sapiens_hsa051691.22991411
41Choline metabolism in cancer_Homo sapiens_hsa052311.21376888
42Glioma_Homo sapiens_hsa052141.17442199
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17277355
44Oocyte meiosis_Homo sapiens_hsa041141.17026933
45GnRH signaling pathway_Homo sapiens_hsa049121.11666929
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08574439
47Osteoclast differentiation_Homo sapiens_hsa043801.08019727
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03311768
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01537988
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01457110
51ECM-receptor interaction_Homo sapiens_hsa045120.95819075
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95500904
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.93001267
54Viral carcinogenesis_Homo sapiens_hsa052030.92888527
55ErbB signaling pathway_Homo sapiens_hsa040120.92306815
56Vibrio cholerae infection_Homo sapiens_hsa051100.91158083
57Herpes simplex infection_Homo sapiens_hsa051680.90904135
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.90676908
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90045906
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.89627319
61T cell receptor signaling pathway_Homo sapiens_hsa046600.88993428
62Endometrial cancer_Homo sapiens_hsa052130.87309787
63Focal adhesion_Homo sapiens_hsa045100.84719826
64Systemic lupus erythematosus_Homo sapiens_hsa053220.83858857
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81365933
66Insulin signaling pathway_Homo sapiens_hsa049100.79386336
67Long-term potentiation_Homo sapiens_hsa047200.77901783
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75628227
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75007887
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73984571
71HTLV-I infection_Homo sapiens_hsa051660.73970570
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73823143
73Salmonella infection_Homo sapiens_hsa051320.73698497
74Biosynthesis of amino acids_Homo sapiens_hsa012300.72602735
75Lysosome_Homo sapiens_hsa041420.72314113
76Gap junction_Homo sapiens_hsa045400.70919040
77Vitamin B6 metabolism_Homo sapiens_hsa007500.70053433
78Amoebiasis_Homo sapiens_hsa051460.69545306
79Inositol phosphate metabolism_Homo sapiens_hsa005620.69408362
80Prion diseases_Homo sapiens_hsa050200.69260234
81AMPK signaling pathway_Homo sapiens_hsa041520.69192852
82Pentose phosphate pathway_Homo sapiens_hsa000300.68643919
83Rap1 signaling pathway_Homo sapiens_hsa040150.67577278
84Huntingtons disease_Homo sapiens_hsa050160.66863389
85Estrogen signaling pathway_Homo sapiens_hsa049150.65526916
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64663127
87Toxoplasmosis_Homo sapiens_hsa051450.63557962
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63237723
89Folate biosynthesis_Homo sapiens_hsa007900.63105581
90MicroRNAs in cancer_Homo sapiens_hsa052060.62482946
91Hippo signaling pathway_Homo sapiens_hsa043900.62361669
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.62258935
93Chemokine signaling pathway_Homo sapiens_hsa040620.62199201
94Leishmaniasis_Homo sapiens_hsa051400.61107149
95Fructose and mannose metabolism_Homo sapiens_hsa000510.60992393
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59854784
97Basal cell carcinoma_Homo sapiens_hsa052170.58675932
98Thyroid cancer_Homo sapiens_hsa052160.57363006
99Antigen processing and presentation_Homo sapiens_hsa046120.56536337
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56332653
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56088033
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56068568
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.55171506
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54986401
105MAPK signaling pathway_Homo sapiens_hsa040100.54219493
106Notch signaling pathway_Homo sapiens_hsa043300.54002194
107TGF-beta signaling pathway_Homo sapiens_hsa043500.53765519
108Renal cell carcinoma_Homo sapiens_hsa052110.52640169
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52224210
110Collecting duct acid secretion_Homo sapiens_hsa049660.50936807
111Pertussis_Homo sapiens_hsa051330.50248490
112TNF signaling pathway_Homo sapiens_hsa046680.50143539
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49268566
114Selenocompound metabolism_Homo sapiens_hsa004500.49209250
115Colorectal cancer_Homo sapiens_hsa052100.49092016
116Hepatitis C_Homo sapiens_hsa051600.48328535
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.47604697
118Small cell lung cancer_Homo sapiens_hsa052220.46978506
119Shigellosis_Homo sapiens_hsa051310.42255177
120Parkinsons disease_Homo sapiens_hsa050120.42148949
121Apoptosis_Homo sapiens_hsa042100.41099007
122Legionellosis_Homo sapiens_hsa051340.40192500
123Protein export_Homo sapiens_hsa030600.39127491
124Hedgehog signaling pathway_Homo sapiens_hsa043400.37137161
125Alcoholism_Homo sapiens_hsa050340.36690471
126Glutathione metabolism_Homo sapiens_hsa004800.36025061
127Galactose metabolism_Homo sapiens_hsa000520.32973424
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32000740
129Pathways in cancer_Homo sapiens_hsa052000.31765197
130HIF-1 signaling pathway_Homo sapiens_hsa040660.31111153
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28810227
132Hepatitis B_Homo sapiens_hsa051610.28215964
133Bladder cancer_Homo sapiens_hsa052190.27757827
134Measles_Homo sapiens_hsa051620.27601383
135Primary immunodeficiency_Homo sapiens_hsa053400.26979650
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26141390
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25319170
138N-Glycan biosynthesis_Homo sapiens_hsa005100.25194211
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.21668898
140Carbon metabolism_Homo sapiens_hsa012000.21475221
141Arachidonic acid metabolism_Homo sapiens_hsa005900.20493866
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18371474
143Influenza A_Homo sapiens_hsa051640.18045605
144Adherens junction_Homo sapiens_hsa045200.16969799
145Wnt signaling pathway_Homo sapiens_hsa043100.16864874
146Chronic myeloid leukemia_Homo sapiens_hsa052200.16640967
147Sulfur relay system_Homo sapiens_hsa041220.16270869
148Regulation of autophagy_Homo sapiens_hsa041400.16014869
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13711293
150Viral myocarditis_Homo sapiens_hsa054160.13659422
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13083572
152Tight junction_Homo sapiens_hsa045300.12150018
153NF-kappa B signaling pathway_Homo sapiens_hsa040640.12081736
154Oxidative phosphorylation_Homo sapiens_hsa001900.11989226
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11980926
156Metabolic pathways_Homo sapiens_hsa011000.11919906
157mTOR signaling pathway_Homo sapiens_hsa041500.11668304
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10959712
159Melanoma_Homo sapiens_hsa052180.09473080
160Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08498457
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08021848
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07846447
163NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07195968
164Hematopoietic cell lineage_Homo sapiens_hsa046400.06895055

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