CENPU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.15608426
2telomere maintenance via semi-conservative replication (GO:0032201)5.05105913
3* CENP-A containing nucleosome assembly (GO:0034080)5.03883482
4* chromatin remodeling at centromere (GO:0031055)4.99732863
5DNA strand elongation (GO:0022616)4.94113644
6DNA replication checkpoint (GO:0000076)4.93940033
7protein localization to kinetochore (GO:0034501)4.87954676
8kinetochore organization (GO:0051383)4.82251449
9DNA replication initiation (GO:0006270)4.77979929
10telomere maintenance via recombination (GO:0000722)4.65541432
11establishment of integrated proviral latency (GO:0075713)4.60634656
12mitotic metaphase plate congression (GO:0007080)4.53438410
13DNA ligation (GO:0006266)4.45595218
14* DNA replication-independent nucleosome organization (GO:0034724)4.45058510
15* DNA replication-independent nucleosome assembly (GO:0006336)4.45058510
16kinetochore assembly (GO:0051382)4.44853791
17mitotic recombination (GO:0006312)4.41443334
18protein localization to chromosome, centromeric region (GO:0071459)4.41034781
19synapsis (GO:0007129)4.37190180
20* histone exchange (GO:0043486)4.33512727
21attachment of spindle microtubules to kinetochore (GO:0008608)4.33450220
22DNA replication-dependent nucleosome organization (GO:0034723)4.09901129
23DNA replication-dependent nucleosome assembly (GO:0006335)4.09901129
24DNA unwinding involved in DNA replication (GO:0006268)4.04848689
25telomere maintenance via telomere lengthening (GO:0010833)4.03216174
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.01120569
27meiotic chromosome segregation (GO:0045132)3.99982156
28metaphase plate congression (GO:0051310)3.99384167
29mitotic nuclear envelope disassembly (GO:0007077)3.92024890
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.90055650
31nuclear pore organization (GO:0006999)3.88674407
32nucleobase biosynthetic process (GO:0046112)3.88343992
33nuclear pore complex assembly (GO:0051292)3.86522571
34mitotic chromosome condensation (GO:0007076)3.86144646
35ribosomal small subunit assembly (GO:0000028)3.85500638
36DNA synthesis involved in DNA repair (GO:0000731)3.84265383
37DNA topological change (GO:0006265)3.83064164
38mitotic sister chromatid segregation (GO:0000070)3.83016750
39maturation of SSU-rRNA (GO:0030490)3.77095538
40establishment of chromosome localization (GO:0051303)3.75119831
41DNA deamination (GO:0045006)3.65896615
42purine nucleobase biosynthetic process (GO:0009113)3.63666976
43IMP biosynthetic process (GO:0006188)3.62832102
44nuclear envelope disassembly (GO:0051081)3.61717344
45membrane disassembly (GO:0030397)3.61717344
46regulation of DNA endoreduplication (GO:0032875)3.60770213
47establishment of viral latency (GO:0019043)3.50141821
48regulation of spindle organization (GO:0090224)3.47495980
49sister chromatid segregation (GO:0000819)3.45562734
50chromosome organization involved in meiosis (GO:0070192)3.45190623
51DNA double-strand break processing (GO:0000729)3.43303554
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.42112938
53* chromatin assembly or disassembly (GO:0006333)3.40898897
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40845029
55mitotic G2/M transition checkpoint (GO:0044818)3.39897087
56regulation of centrosome cycle (GO:0046605)3.39224404
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.38110188
58non-recombinational repair (GO:0000726)3.32334309
59double-strand break repair via nonhomologous end joining (GO:0006303)3.32334309
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.31295569
61chromosome segregation (GO:0007059)3.30832034
62replication fork processing (GO:0031297)3.30491067
63DNA catabolic process, exonucleolytic (GO:0000738)3.30192284
64regulation of centriole replication (GO:0046599)3.28611503
65spindle checkpoint (GO:0031577)3.27952895
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27929209
67regulation of chromosome segregation (GO:0051983)3.27225436
68centriole replication (GO:0007099)3.24840772
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24731787
70formation of translation preinitiation complex (GO:0001731)3.24582993
71DNA packaging (GO:0006323)3.24349278
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.21871401
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21871401
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21871401
75negative regulation of sister chromatid segregation (GO:0033046)3.21871401
76negative regulation of chromosome segregation (GO:0051985)3.21421519
77* ATP-dependent chromatin remodeling (GO:0043044)3.20886784
78protein localization to chromosome (GO:0034502)3.19312662
79translesion synthesis (GO:0019985)3.18915538
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.18531586
81somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18531586
82telomere maintenance (GO:0000723)3.18500603
83proteasome assembly (GO:0043248)3.17775943
84telomere organization (GO:0032200)3.17240303
85IMP metabolic process (GO:0046040)3.16592512
86protein K6-linked ubiquitination (GO:0085020)3.16451464
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16226781
88transcription-coupled nucleotide-excision repair (GO:0006283)3.15994062
89deoxyribonucleotide biosynthetic process (GO:0009263)3.15872443
90ribosome biogenesis (GO:0042254)3.15860585
91negative regulation of mitosis (GO:0045839)3.15824240
92mitotic sister chromatid cohesion (GO:0007064)3.15342447
93ribosomal large subunit biogenesis (GO:0042273)3.14459437
94regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14393934
95mismatch repair (GO:0006298)3.14290279
96postreplication repair (GO:0006301)3.13993159
97regulation of mitotic spindle checkpoint (GO:1903504)3.13648381
98resolution of meiotic recombination intermediates (GO:0000712)3.12593330
99folic acid-containing compound biosynthetic process (GO:0009396)3.12404948
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11455022
101spindle assembly checkpoint (GO:0071173)3.11453226
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10202125
103ribonucleoprotein complex biogenesis (GO:0022613)3.09309093
104positive regulation of chromosome segregation (GO:0051984)3.07273870
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06981429
106ribosome assembly (GO:0042255)3.05617257
107* mitotic cell cycle (GO:0000278)3.03461038
108ribosomal small subunit biogenesis (GO:0042274)3.02656662
109spliceosomal snRNP assembly (GO:0000387)3.02548733
110pore complex assembly (GO:0046931)3.02181170
111G1/S transition of mitotic cell cycle (GO:0000082)3.02060165
112cell cycle G1/S phase transition (GO:0044843)3.02060165
113rRNA processing (GO:0006364)3.01288885
114mitotic spindle assembly checkpoint (GO:0007094)3.00888423
115translational termination (GO:0006415)2.99823104
116viral transcription (GO:0019083)2.99628224
117mitotic spindle checkpoint (GO:0071174)2.98059738
118regulation of sister chromatid segregation (GO:0033045)2.97767286
119regulation of mitotic sister chromatid separation (GO:0010965)2.97767286
120regulation of mitotic sister chromatid segregation (GO:0033047)2.97767286
121DNA geometric change (GO:0032392)2.97007376
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95915261
123regulation of mitotic spindle organization (GO:0060236)2.95644133
124DNA duplex unwinding (GO:0032508)2.95114737
125rRNA metabolic process (GO:0016072)2.93124459
126chromosome condensation (GO:0030261)2.92110406
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91880810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.66575446
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77354883
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21541187
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.14381394
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.66349885
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34858495
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31636123
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.20423566
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.98109295
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83075310
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79298135
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.79067030
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75319934
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69014384
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.60936576
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51652701
17AR_21909140_ChIP-Seq_LNCAP_Human2.44189766
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34318011
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33653703
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23673641
21XRN2_22483619_ChIP-Seq_HELA_Human2.20990193
22VDR_23849224_ChIP-Seq_CD4+_Human2.18687361
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.16168901
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10572450
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01591582
26FOXP3_21729870_ChIP-Seq_TREG_Human1.97864930
27DCP1A_22483619_ChIP-Seq_HELA_Human1.96905046
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94418456
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90195697
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89294430
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88722661
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83643464
33TTF2_22483619_ChIP-Seq_HELA_Human1.78477969
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78319412
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78077092
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76460832
37GABP_19822575_ChIP-Seq_HepG2_Human1.74541437
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71042144
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69076819
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67570140
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65092815
42ELK1_19687146_ChIP-ChIP_HELA_Human1.63664151
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62058461
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59492188
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.50982407
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50386829
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.50355003
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48563816
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48190479
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46454028
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45858576
52CIITA_25753668_ChIP-Seq_RAJI_Human1.39182242
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38402978
54KDM5A_27292631_Chip-Seq_BREAST_Human1.35531341
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.34138086
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23728647
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21972609
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21947545
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21674718
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21019102
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18920873
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17981718
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17911252
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16976199
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15838521
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15149777
67MYC_18940864_ChIP-ChIP_HL60_Human1.13684704
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.12543425
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12356957
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10798407
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10470391
72MYC_22102868_ChIP-Seq_BL_Human1.09848974
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.07495764
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.05519424
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02007646
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01535816
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01508644
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99930394
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98106943
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96499644
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96364163
82EWS_26573619_Chip-Seq_HEK293_Human0.95372987
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94628378
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93679465
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91767328
86IRF1_19129219_ChIP-ChIP_H3396_Human0.91336902
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.90572985
88RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89918072
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89166705
90SPI1_23547873_ChIP-Seq_NB4_Human0.88801553
91TFEB_21752829_ChIP-Seq_HELA_Human0.85529784
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.84498416
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82706205
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.77641001
95FUS_26573619_Chip-Seq_HEK293_Human0.77574729
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76848666
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75836952
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74181357
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73680004
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.72787970
101SALL1_21062744_ChIP-ChIP_HESCs_Human0.71617451
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.71391187
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.71391187
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.71391187
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71324020
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69267166
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68259152
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67433041
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67267977
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.66926461
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66659334
112VDR_21846776_ChIP-Seq_THP-1_Human0.65312232
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.63398642
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.63081990
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.61794371
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.60408256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.73630314
2MP0010094_abnormal_chromosome_stability5.21746202
3MP0003111_abnormal_nucleus_morphology4.82362311
4MP0008057_abnormal_DNA_replication4.50459816
5MP0004957_abnormal_blastocyst_morpholog4.47281362
6MP0003077_abnormal_cell_cycle4.27734097
7MP0008058_abnormal_DNA_repair3.81243934
8MP0008877_abnormal_DNA_methylation2.97384859
9MP0008007_abnormal_cellular_replicative2.97168413
10MP0008932_abnormal_embryonic_tissue2.74930863
11MP0002396_abnormal_hematopoietic_system2.54424981
12MP0003123_paternal_imprinting2.44703361
13MP0000350_abnormal_cell_proliferation2.20077503
14MP0001730_embryonic_growth_arrest2.12570663
15MP0003786_premature_aging2.04948769
16MP0002210_abnormal_sex_determination1.90916979
17MP0001929_abnormal_gametogenesis1.85030775
18MP0003718_maternal_effect1.82113624
19MP0010307_abnormal_tumor_latency1.81701001
20MP0000490_abnormal_crypts_of1.78414752
21MP0005410_abnormal_fertilization1.70617721
22MP0010352_gastrointestinal_tract_polyps1.65166740
23MP0001145_abnormal_male_reproductive1.63059618
24MP0001697_abnormal_embryo_size1.62859939
25MP0004808_abnormal_hematopoietic_stem1.60159156
26MP0005380_embryogenesis_phenotype1.58071760
27MP0001672_abnormal_embryogenesis/_devel1.58071760
28MP0000313_abnormal_cell_death1.49239746
29MP0002019_abnormal_tumor_incidence1.47255028
30MP0008789_abnormal_olfactory_epithelium1.46333462
31MP0000653_abnormal_sex_gland1.44684726
32MP0002080_prenatal_lethality1.44547408
33MP0002085_abnormal_embryonic_tissue1.38797606
34MP0003984_embryonic_growth_retardation1.35492786
35MP0003698_abnormal_male_reproductive1.31927336
36MP0002088_abnormal_embryonic_growth/wei1.31200446
37MP0005397_hematopoietic_system_phenotyp1.30104394
38MP0001545_abnormal_hematopoietic_system1.30104394
39MP0004147_increased_porphyrin_level1.30062244
40MP0003806_abnormal_nucleotide_metabolis1.28399503
41MP0002084_abnormal_developmental_patter1.23850652
42MP0003890_abnormal_embryonic-extraembry1.21232427
43MP0002086_abnormal_extraembryonic_tissu1.19428972
44MP0003121_genomic_imprinting1.18141650
45MP0003315_abnormal_perineum_morphology1.16589692
46MP0001119_abnormal_female_reproductive1.13652149
47MP0009333_abnormal_splenocyte_physiolog1.13345979
48MP0004197_abnormal_fetal_growth/weight/1.11291231
49MP0002160_abnormal_reproductive_system1.10459029
50MP0002398_abnormal_bone_marrow1.08768184
51MP0006292_abnormal_olfactory_placode1.08579711
52MP0002697_abnormal_eye_size1.05559561
53MP0001286_abnormal_eye_development1.05314668
54MP0000703_abnormal_thymus_morphology1.03921329
55MP0003763_abnormal_thymus_physiology1.03761605
56MP0005394_taste/olfaction_phenotype1.03537091
57MP0005499_abnormal_olfactory_system1.03537091
58MP0009697_abnormal_copulation1.03153994
59MP0001293_anophthalmia1.02921531
60MP0002722_abnormal_immune_system1.00457227
61MP0006054_spinal_hemorrhage0.99906985
62MP0003567_abnormal_fetal_cardiomyocyte0.99635978
63MP0000689_abnormal_spleen_morphology0.99374406
64MP0005076_abnormal_cell_differentiation0.99348647
65MP0001529_abnormal_vocalization0.94786429
66MP0002161_abnormal_fertility/fecundity0.94192851
67MP0003186_abnormal_redox_activity0.94121011
68MP0008995_early_reproductive_senescence0.92583507
69MP0005389_reproductive_system_phenotype0.88683202
70MP0000858_altered_metastatic_potential0.88609630
71MP0002233_abnormal_nose_morphology0.86887711
72MP0003136_yellow_coat_color0.84629917
73MP0000358_abnormal_cell_content/0.83718493
74MP0002429_abnormal_blood_cell0.83615481
75MP0009703_decreased_birth_body0.82947346
76MP0006072_abnormal_retinal_apoptosis0.82780387
77MP0003119_abnormal_digestive_system0.80389109
78MP0002132_abnormal_respiratory_system0.80335452
79MP0000049_abnormal_middle_ear0.77722264
80MP0002095_abnormal_skin_pigmentation0.76813488
81MP0002102_abnormal_ear_morphology0.76140539
82MP0002653_abnormal_ependyma_morphology0.76026503
83MP0005384_cellular_phenotype0.75813755
84MP0005075_abnormal_melanosome_morpholog0.75746787
85MP0010030_abnormal_orbit_morphology0.75443123
86MP0001188_hyperpigmentation0.75225387
87MP0001346_abnormal_lacrimal_gland0.72836325
88MP0001915_intracranial_hemorrhage0.71016532
89MP0000428_abnormal_craniofacial_morphol0.70805701
90MP0005621_abnormal_cell_physiology0.70735360
91MP0001853_heart_inflammation0.70233380
92MP0005174_abnormal_tail_pigmentation0.69827880
93MP0002234_abnormal_pharynx_morphology0.69538847
94MP0003656_abnormal_erythrocyte_physiolo0.68650342
95MP0000716_abnormal_immune_system0.68110283
96MP0005395_other_phenotype0.67698028
97MP0003699_abnormal_female_reproductive0.66555874
98MP0003861_abnormal_nervous_system0.65439511
99MP0006036_abnormal_mitochondrial_physio0.64173421
100MP0005501_abnormal_skin_physiology0.63918045
101MP0003937_abnormal_limbs/digits/tail_de0.63218506
102MP0002092_abnormal_eye_morphology0.62772325
103MP0009672_abnormal_birth_weight0.59772093
104MP0004133_heterotaxia0.59622962
105MP0005023_abnormal_wound_healing0.59255592
106MP0002075_abnormal_coat/hair_pigmentati0.58989542
107MP0001919_abnormal_reproductive_system0.58906905
108MP0000566_synostosis0.57474597
109MP0005266_abnormal_metabolism0.56985939
110MP0001727_abnormal_embryo_implantation0.56158998
111MP0009053_abnormal_anal_canal0.55403713
112MP0000537_abnormal_urethra_morphology0.54603686
113MP0001800_abnormal_humoral_immune0.54305850
114MP0002420_abnormal_adaptive_immunity0.53549792
115MP0002111_abnormal_tail_morphology0.53536683
116MP0003941_abnormal_skin_development0.52799630
117MP0001819_abnormal_immune_cell0.52533626
118MP0003943_abnormal_hepatobiliary_system0.52227119
119MP0009379_abnormal_foot_pigmentation0.51901396
120MP0000477_abnormal_intestine_morphology0.51714032
121MP0001835_abnormal_antigen_presentation0.50881807
122MP0000372_irregular_coat_pigmentation0.50832446
123MP0006035_abnormal_mitochondrial_morpho0.50599563
124MP0002751_abnormal_autonomic_nervous0.50417361
125MP0002452_abnormal_antigen_presenting0.50110861
126MP0002405_respiratory_system_inflammati0.49887221
127MP0000647_abnormal_sebaceous_gland0.49325267
128MP0003755_abnormal_palate_morphology0.48840272
129MP0002938_white_spotting0.48791279
130MP0005391_vision/eye_phenotype0.47722041
131MP0001881_abnormal_mammary_gland0.47134736

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.01566068
2Chromsome breakage (HP:0040012)4.82074269
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.49437121
4Breast hypoplasia (HP:0003187)4.44543206
5Reticulocytopenia (HP:0001896)4.39206365
6Patellar aplasia (HP:0006443)3.67633542
7Abnormality of cells of the erythroid lineage (HP:0012130)3.60915814
8Abnormality of chromosome stability (HP:0003220)3.60703531
9Abnormal number of erythroid precursors (HP:0012131)3.54653161
10Meckel diverticulum (HP:0002245)3.48908016
11Oral leukoplakia (HP:0002745)3.46860686
12Aplasia/Hypoplasia of the patella (HP:0006498)3.44755664
13Abnormality of the preputium (HP:0100587)3.44705096
14Carpal bone hypoplasia (HP:0001498)3.40521472
15Colon cancer (HP:0003003)3.37312527
16Impulsivity (HP:0100710)3.36236100
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.32337547
18Abnormality of the ileum (HP:0001549)3.32061061
19Selective tooth agenesis (HP:0001592)3.22933713
20Aplastic anemia (HP:0001915)3.22351780
2111 pairs of ribs (HP:0000878)3.13309736
22Degeneration of anterior horn cells (HP:0002398)3.09905047
23Abnormality of the anterior horn cell (HP:0006802)3.09905047
24Duodenal stenosis (HP:0100867)3.08466676
25Small intestinal stenosis (HP:0012848)3.08466676
26Myelodysplasia (HP:0002863)2.99323146
27Absent radius (HP:0003974)2.93879610
28Duplicated collecting system (HP:0000081)2.92896753
29Absent thumb (HP:0009777)2.89939625
30Ectopic kidney (HP:0000086)2.87992708
31Abnormal lung lobation (HP:0002101)2.79193320
32Aplasia involving forearm bones (HP:0009822)2.76144436
33Absent forearm bone (HP:0003953)2.76144436
34Bone marrow hypocellularity (HP:0005528)2.72785305
35Pallor (HP:0000980)2.72463392
36Rough bone trabeculation (HP:0100670)2.72291755
37Horseshoe kidney (HP:0000085)2.69039049
38Macrocytic anemia (HP:0001972)2.69013097
39Supernumerary spleens (HP:0009799)2.67495980
40Sloping forehead (HP:0000340)2.65288299
41Medulloblastoma (HP:0002885)2.64978548
42Abnormality of the renal collecting system (HP:0004742)2.59455296
43Agnosia (HP:0010524)2.59236435
44Cerebral hypomyelination (HP:0006808)2.58005361
45Abnormality of the duodenum (HP:0002246)2.47905295
46Microvesicular hepatic steatosis (HP:0001414)2.46538363
47Abnormality of cochlea (HP:0000375)2.45275635
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44723208
49Abnormality of the labia minora (HP:0012880)2.42577956
50Abnormal spermatogenesis (HP:0008669)2.40625188
51Multiple enchondromatosis (HP:0005701)2.38642406
52Acute necrotizing encephalopathy (HP:0006965)2.37869234
53Pancytopenia (HP:0001876)2.36853619
54Premature graying of hair (HP:0002216)2.34427620
55Triphalangeal thumb (HP:0001199)2.33263100
56Acute encephalopathy (HP:0006846)2.33050215
57Neoplasm of the pancreas (HP:0002894)2.32104981
58Tracheoesophageal fistula (HP:0002575)2.28683897
59Cleft eyelid (HP:0000625)2.28666567
60Microretrognathia (HP:0000308)2.27542899
61Rhabdomyosarcoma (HP:0002859)2.22830487
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.21626898
63Increased hepatocellular lipid droplets (HP:0006565)2.21409824
64Ependymoma (HP:0002888)2.20048128
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19933247
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.19122242
67Clubbing of toes (HP:0100760)2.18400345
68Abnormal mitochondria in muscle tissue (HP:0008316)2.18230963
69Abnormality of the carotid arteries (HP:0005344)2.15918621
70Cellular immunodeficiency (HP:0005374)2.15123313
71Short thumb (HP:0009778)2.13297165
72Nephroblastoma (Wilms tumor) (HP:0002667)2.12471932
73Septo-optic dysplasia (HP:0100842)2.10552780
74Cortical dysplasia (HP:0002539)2.10429185
75Increased nuchal translucency (HP:0010880)2.08439276
76Atresia of the external auditory canal (HP:0000413)2.07866707
77Premature ovarian failure (HP:0008209)2.06370138
78Thrombocytosis (HP:0001894)2.05517948
79Abnormality of pyrimidine metabolism (HP:0004353)2.03704858
80Increased CSF lactate (HP:0002490)2.03089163
81Duplication of thumb phalanx (HP:0009942)2.02916460
82Secondary amenorrhea (HP:0000869)2.02770837
83Lipid accumulation in hepatocytes (HP:0006561)1.98484760
84Muscle fiber atrophy (HP:0100295)1.98106034
85Choanal atresia (HP:0000453)1.97137587
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96391779
87Embryonal renal neoplasm (HP:0011794)1.96075986
88Abnormal number of incisors (HP:0011064)1.95662603
89Abnormality of DNA repair (HP:0003254)1.95241242
90Neoplasm of the colon (HP:0100273)1.94329197
91Absent septum pellucidum (HP:0001331)1.94243294
92Mitochondrial inheritance (HP:0001427)1.93060692
93Type 2 muscle fiber atrophy (HP:0003554)1.92958466
94Volvulus (HP:0002580)1.91725159
95Abnormality of the septum pellucidum (HP:0007375)1.91477583
96Slender long bone (HP:0003100)1.91266655
97Poor head control (HP:0002421)1.90511329
98Missing ribs (HP:0000921)1.89820866
99Abnormal trabecular bone morphology (HP:0100671)1.89013373
100Embryonal neoplasm (HP:0002898)1.88880923
101Megaloblastic anemia (HP:0001889)1.87257235
102Arteriovenous malformation (HP:0100026)1.85570899
103Abnormality of methionine metabolism (HP:0010901)1.84415899
104Hypoplasia of the radius (HP:0002984)1.83910842
105Ureteral duplication (HP:0000073)1.81746590
106Type I transferrin isoform profile (HP:0003642)1.80553211
107Cerebral edema (HP:0002181)1.80138836
108Abnormal respiratory motile cilium morphology (HP:0005938)1.80066258
109Abnormal respiratory epithelium morphology (HP:0012253)1.80066258
110Abnormality of reticulocytes (HP:0004312)1.79548989
111Cafe-au-lait spot (HP:0000957)1.79279787
112Trismus (HP:0000211)1.79275169
113Facial cleft (HP:0002006)1.78545759
114Acute myeloid leukemia (HP:0004808)1.78476443
115Irregular epiphyses (HP:0010582)1.78037979
116Increased serum lactate (HP:0002151)1.77950898
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.77706082
118Facial hemangioma (HP:0000329)1.77592629
119Short middle phalanx of the 5th finger (HP:0004220)1.75994694
120Progressive macrocephaly (HP:0004481)1.75730789
121Increased serum pyruvate (HP:0003542)1.75691867
122Glioma (HP:0009733)1.74621122
123Lymphoma (HP:0002665)1.74486161
124Squamous cell carcinoma (HP:0002860)1.73976551
125Morphological abnormality of the inner ear (HP:0011390)1.73600794
126Basal cell carcinoma (HP:0002671)1.73560235
127Amaurosis fugax (HP:0100576)1.71439726
128Hepatocellular necrosis (HP:0001404)1.68201498
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67593532
130Postnatal microcephaly (HP:0005484)1.65025604
131Abnormality of glycolysis (HP:0004366)1.63780822
132Hyperglycinemia (HP:0002154)1.62499998
133Small hand (HP:0200055)1.60964758
134Hypoplastic pelvis (HP:0008839)1.60205728
135Gonadotropin excess (HP:0000837)1.59336060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.99537499
2WEE14.54710666
3BUB14.07125402
4PLK43.44449627
5SRPK13.18749688
6NEK23.09995769
7EIF2AK13.08734355
8VRK23.02766812
9TTK2.68201480
10BRSK22.45683571
11ACVR1B2.45561753
12* PLK12.17273261
13NEK12.16874532
14VRK12.09472162
15CCNB11.97383605
16NME21.86006567
17TLK11.81236880
18AURKB1.80742754
19ATR1.80582329
20BRSK11.75173658
21TAF11.74153087
22EIF2AK31.70666559
23CDK71.66207480
24MKNK11.65909705
25DYRK31.58637843
26PLK31.58607492
27CHEK21.53937816
28PBK1.48064711
29NUAK11.44961893
30PASK1.40122288
31MELK1.39918620
32TSSK61.35428361
33STK41.34574106
34TESK21.34494398
35STK161.26582964
36PDK41.26276099
37PDK31.26276099
38CDK121.26085253
39CDK81.25630400
40AURKA1.21687068
41TRIM281.20598388
42ZAK1.20136778
43CHEK11.17763116
44MAP3K81.17719598
45CDK41.17542445
46RPS6KA41.16251855
47RPS6KB21.16028784
48MKNK21.13924721
49CLK11.09332599
50TGFBR11.06560499
51CDK191.02972647
52STK101.02964879
53PIM11.01591581
54ATM0.94216322
55BLK0.94034037
56TESK10.91730295
57EIF2AK20.87179107
58NME10.82786346
59PAK40.80686225
60CDK20.78779224
61BRAF0.73245953
62BMPR1B0.72329856
63TNIK0.71210314
64MAP3K100.68876152
65CSNK2A10.68511672
66PDK20.65126389
67SMG10.65028594
68CDK10.64905819
69CSNK2A20.64049873
70PIM20.63854956
71BRD40.63529728
72MAP4K10.60388678
73EEF2K0.59812580
74PNCK0.57024450
75WNK30.54203044
76CDK30.54195582
77EPHA20.52940564
78CSNK1G10.52638361
79STK30.51875867
80PAK10.51263161
81IRAK40.49258058
82CSNK1G30.48648016
83CDK60.48041835
84FLT30.46571263
85KIT0.46284397
86STK38L0.44944072
87RPS6KA50.42398655
88DAPK10.41859904
89CDK11A0.40073607
90BCKDK0.39014124
91TEC0.37941882
92SCYL20.37717709
93CDK180.36414851
94CDK150.36354774
95CDK140.35741451
96PRKCI0.33277241
97ZAP700.32202398
98CSNK1G20.32084082
99IRAK30.31736752
100NLK0.28702992
101CSNK1A1L0.28236091
102BTK0.27897161
103DYRK20.27456863
104ERBB40.26157539
105BCR0.26083654
106PRKDC0.25544813
107NEK90.25277093
108YES10.24323175
109LATS20.24087718
110ABL20.23223916
111KDR0.22752185
112MAP3K50.21791561
113PLK20.21230006
114FGFR10.19312797
115STK240.19304654
116AKT20.18638877
117CSNK1E0.17895037
118ALK0.17185121
119LYN0.16397325
120MAPK140.16396611
121LRRK20.15800486
122MATK0.14641017
123MAPKAPK30.13869901
124CDK90.13710197
125MAP3K60.13559716
126MST40.13370201

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.49703403
2Mismatch repair_Homo sapiens_hsa034304.56431890
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50715677
4Homologous recombination_Homo sapiens_hsa034403.45141717
5Proteasome_Homo sapiens_hsa030503.24703386
6Base excision repair_Homo sapiens_hsa034103.21083087
7Ribosome_Homo sapiens_hsa030103.14890698
8RNA polymerase_Homo sapiens_hsa030203.08336270
9Spliceosome_Homo sapiens_hsa030403.06716904
10RNA transport_Homo sapiens_hsa030133.06046283
11Nucleotide excision repair_Homo sapiens_hsa034202.99554670
12Cell cycle_Homo sapiens_hsa041102.98676153
13One carbon pool by folate_Homo sapiens_hsa006702.69669541
14Pyrimidine metabolism_Homo sapiens_hsa002402.60762846
15Fanconi anemia pathway_Homo sapiens_hsa034602.59628444
16Non-homologous end-joining_Homo sapiens_hsa034502.33274210
17Basal transcription factors_Homo sapiens_hsa030222.13102191
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03801180
19RNA degradation_Homo sapiens_hsa030182.03082048
20mRNA surveillance pathway_Homo sapiens_hsa030151.65923314
21p53 signaling pathway_Homo sapiens_hsa041151.64932421
22Purine metabolism_Homo sapiens_hsa002301.46220035
23Systemic lupus erythematosus_Homo sapiens_hsa053221.40471559
24Pyruvate metabolism_Homo sapiens_hsa006201.24508438
25Oocyte meiosis_Homo sapiens_hsa041141.17944159
26Epstein-Barr virus infection_Homo sapiens_hsa051691.17657968
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17233963
28Propanoate metabolism_Homo sapiens_hsa006401.16680429
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15426589
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12912704
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12880297
32Herpes simplex infection_Homo sapiens_hsa051681.01160609
33Vitamin B6 metabolism_Homo sapiens_hsa007500.96920597
34Pentose phosphate pathway_Homo sapiens_hsa000300.94982670
35Fatty acid elongation_Homo sapiens_hsa000620.93143419
36Antigen processing and presentation_Homo sapiens_hsa046120.90405497
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88484393
38Viral carcinogenesis_Homo sapiens_hsa052030.86475065
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.86470309
40Folate biosynthesis_Homo sapiens_hsa007900.85008307
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83727498
42Protein export_Homo sapiens_hsa030600.83513442
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72953150
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71724544
45Huntingtons disease_Homo sapiens_hsa050160.71425304
46Alzheimers disease_Homo sapiens_hsa050100.70904901
47Selenocompound metabolism_Homo sapiens_hsa004500.69878935
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.66681952
49HTLV-I infection_Homo sapiens_hsa051660.65843980
50Biosynthesis of amino acids_Homo sapiens_hsa012300.64862646
51Glutathione metabolism_Homo sapiens_hsa004800.64701224
52Steroid biosynthesis_Homo sapiens_hsa001000.64673351
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63545130
54Sulfur relay system_Homo sapiens_hsa041220.62097763
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60977320
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.60333129
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52629159
58Legionellosis_Homo sapiens_hsa051340.52145060
59Small cell lung cancer_Homo sapiens_hsa052220.48456697
60Thyroid cancer_Homo sapiens_hsa052160.48211605
61MicroRNAs in cancer_Homo sapiens_hsa052060.47997432
62Alcoholism_Homo sapiens_hsa050340.47037431
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45353869
64N-Glycan biosynthesis_Homo sapiens_hsa005100.44926841
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43372324
66Lysine degradation_Homo sapiens_hsa003100.40932639
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40005906
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37319612
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35097204
70Measles_Homo sapiens_hsa051620.35094286
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33693381
72Apoptosis_Homo sapiens_hsa042100.33345342
73Fatty acid metabolism_Homo sapiens_hsa012120.33294905
74Carbon metabolism_Homo sapiens_hsa012000.33137260
75Hepatitis B_Homo sapiens_hsa051610.33006604
76Parkinsons disease_Homo sapiens_hsa050120.31230856
77Primary immunodeficiency_Homo sapiens_hsa053400.31041466
78Fructose and mannose metabolism_Homo sapiens_hsa000510.30455313
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29872740
80Hematopoietic cell lineage_Homo sapiens_hsa046400.27430195
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27378882
82Arachidonic acid metabolism_Homo sapiens_hsa005900.27334939
83Influenza A_Homo sapiens_hsa051640.26016387
84TGF-beta signaling pathway_Homo sapiens_hsa043500.25991865
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.25378956
86Cardiac muscle contraction_Homo sapiens_hsa042600.25107802
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24826321
88Metabolic pathways_Homo sapiens_hsa011000.23701056
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.23686981
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21117839
91Colorectal cancer_Homo sapiens_hsa052100.20597461
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20222101
93Wnt signaling pathway_Homo sapiens_hsa043100.19737094
94Hippo signaling pathway_Homo sapiens_hsa043900.19308449
95Basal cell carcinoma_Homo sapiens_hsa052170.19183565
96Shigellosis_Homo sapiens_hsa051310.18964098
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17687805
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17363274
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16444496
100Peroxisome_Homo sapiens_hsa041460.15777607
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14972718
102Fatty acid degradation_Homo sapiens_hsa000710.14865364
103Arginine and proline metabolism_Homo sapiens_hsa003300.14635239
104Linoleic acid metabolism_Homo sapiens_hsa005910.14180881
105Bladder cancer_Homo sapiens_hsa052190.12290377
106HIF-1 signaling pathway_Homo sapiens_hsa040660.12163770
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11781535
108Pathways in cancer_Homo sapiens_hsa052000.11144303
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10645090
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10186621
111Asthma_Homo sapiens_hsa053100.09954667
112Butanoate metabolism_Homo sapiens_hsa006500.09891593
113Vitamin digestion and absorption_Homo sapiens_hsa049770.09832545
114Graft-versus-host disease_Homo sapiens_hsa053320.09479522
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08396324
116Hedgehog signaling pathway_Homo sapiens_hsa043400.08160096
117Notch signaling pathway_Homo sapiens_hsa043300.07823122
118Oxidative phosphorylation_Homo sapiens_hsa001900.07468336
119Renin-angiotensin system_Homo sapiens_hsa046140.06903378
120Galactose metabolism_Homo sapiens_hsa000520.06088705
121Chronic myeloid leukemia_Homo sapiens_hsa052200.05277393
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03979103
123beta-Alanine metabolism_Homo sapiens_hsa004100.03699911
124Allograft rejection_Homo sapiens_hsa053300.03360471
125Prostate cancer_Homo sapiens_hsa052150.03099053
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02846434
127Adherens junction_Homo sapiens_hsa045200.02471102
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.02004765
129Melanoma_Homo sapiens_hsa052180.00653463

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