CENPUP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.32986868
2positive regulation of gamma-delta T cell activation (GO:0046645)6.30331177
3detection of molecule of bacterial origin (GO:0032490)6.06838646
4B cell receptor signaling pathway (GO:0050853)5.71977237
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53579186
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.53579186
7modulation by symbiont of host immune response (GO:0052553)5.53579186
8positive regulation by symbiont of host defense response (GO:0052509)5.53579186
9modulation by symbiont of host defense response (GO:0052031)5.53579186
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53579186
11cilium or flagellum-dependent cell motility (GO:0001539)5.12778929
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.06010069
13microglial cell activation (GO:0001774)4.88288787
14macrophage activation involved in immune response (GO:0002281)4.87117417
15regulation of gamma-delta T cell activation (GO:0046643)4.56068373
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41787862
17negative regulation of cell killing (GO:0031342)4.41787862
18positive regulation of developmental pigmentation (GO:0048087)4.41498885
19regulation of gamma-delta T cell differentiation (GO:0045586)4.39536067
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.33139545
21regulation of interferon-beta biosynthetic process (GO:0045357)4.15038139
22cellular extravasation (GO:0045123)4.11955220
23macrophage activation (GO:0042116)4.07668894
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06234926
25detection of external biotic stimulus (GO:0098581)4.00750317
26negative thymic T cell selection (GO:0045060)3.92278038
27positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.87959758
28hepatocyte apoptotic process (GO:0097284)3.86555807
29negative T cell selection (GO:0043383)3.85913158
30positive thymic T cell selection (GO:0045059)3.83607864
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82933099
32cellular response to ethanol (GO:0071361)3.81502808
33negative regulation of B cell proliferation (GO:0030889)3.80244781
34regulation of pigment cell differentiation (GO:0050932)3.77996788
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.77018312
36response to host immune response (GO:0052572)3.72859486
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.72859486
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.71713049
39regulation of B cell differentiation (GO:0045577)3.64434777
40positive T cell selection (GO:0043368)3.56968675
41B cell proliferation (GO:0042100)3.56360665
42negative regulation of T-helper cell differentiation (GO:0045623)3.50506216
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.50506216
44T-helper 1 type immune response (GO:0042088)3.50380059
45fucose catabolic process (GO:0019317)3.50150560
46L-fucose metabolic process (GO:0042354)3.50150560
47L-fucose catabolic process (GO:0042355)3.50150560
48positive regulation of B cell differentiation (GO:0045579)3.48353192
49regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.45107737
50retinal rod cell development (GO:0046548)3.43574260
51detection of biotic stimulus (GO:0009595)3.43349826
52positive regulation of granulocyte differentiation (GO:0030854)3.39446210
53response to host (GO:0075136)3.38799770
54response to host defenses (GO:0052200)3.38799770
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.38799770
56cilium movement (GO:0003341)3.37808352
57germinal center formation (GO:0002467)3.35449689
58histone H3-K36 demethylation (GO:0070544)3.31456413
59negative regulation of T cell mediated immunity (GO:0002710)3.30428268
60neutrophil mediated immunity (GO:0002446)3.29926595
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.29057562
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27142750
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25654676
64histone H3-K4 trimethylation (GO:0080182)3.25566008
65myeloid cell activation involved in immune response (GO:0002275)3.22769163
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.21055419
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16862186
68production of molecular mediator involved in inflammatory response (GO:0002532)3.16575563
69T cell migration (GO:0072678)3.15105507
70regulation of interleukin-12 biosynthetic process (GO:0045075)3.13739897
71B cell homeostasis (GO:0001782)3.12506560
72regulation of alpha-beta T cell proliferation (GO:0046640)3.11579821
73regulation of B cell proliferation (GO:0030888)3.11370709
74establishment of protein localization to Golgi (GO:0072600)3.10054716
75axoneme assembly (GO:0035082)3.09224796
76response to interleukin-15 (GO:0070672)3.07887028
77interferon-gamma production (GO:0032609)3.07487647
78detection of other organism (GO:0098543)3.05585308
79myeloid leukocyte mediated immunity (GO:0002444)3.04267209
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03982288
81defense response to protozoan (GO:0042832)3.02555616
82activated T cell proliferation (GO:0050798)2.98247421
83histone mRNA catabolic process (GO:0071044)2.95458009
84positive regulation of interferon-alpha production (GO:0032727)2.94960850
85negative regulation of interleukin-12 production (GO:0032695)2.93377590
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92102618
87mature B cell differentiation (GO:0002335)2.91326910
88neural tube formation (GO:0001841)2.90474122
89regulation of MHC class I biosynthetic process (GO:0045343)2.90240340
90negative regulation of adaptive immune response (GO:0002820)2.89331943
91T cell selection (GO:0045058)2.87448848
92negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.86630251
93protein targeting to Golgi (GO:0000042)2.85650833
94epithelial cilium movement (GO:0003351)2.85373726
95mucosal-associated lymphoid tissue development (GO:0048537)2.84840684
96Peyers patch development (GO:0048541)2.84840684
97positive regulation of B cell proliferation (GO:0030890)2.83534499
98positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80788660
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.80389637
100antigen processing and presentation of endogenous antigen (GO:0019883)2.80366214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.56811722
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.98532929
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73509351
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.62078261
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.29267081
6SCL_19346495_ChIP-Seq_HPC-7_Human3.10528405
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.96269421
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.75827148
9RUNX_20019798_ChIP-Seq_JUKART_Human2.74668715
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62519223
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59337679
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.58425383
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58230457
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37986649
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37637511
16MYB_26560356_Chip-Seq_TH2_Human2.29368164
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27672910
18GATA1_22025678_ChIP-Seq_K562_Human2.27195051
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98778796
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87693206
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80808008
22MYB_26560356_Chip-Seq_TH1_Human1.79614834
23GATA3_27048872_Chip-Seq_THYMUS_Human1.77421826
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.74841588
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74672866
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71672364
27SPI1_23547873_ChIP-Seq_NB4_Human1.69992326
28AR_21572438_ChIP-Seq_LNCaP_Human1.68829907
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65390253
30VDR_24787735_ChIP-Seq_THP-1_Human1.64822081
31NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62169615
32SPI1_23127762_ChIP-Seq_K562_Human1.59579207
33GATA3_26560356_Chip-Seq_TH2_Human1.59368168
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57526493
35TP53_16413492_ChIP-PET_HCT116_Human1.56802608
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56613088
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49409363
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44439522
39SMRT_27268052_Chip-Seq_Bcells_Human1.43842812
40IGF1R_20145208_ChIP-Seq_DFB_Human1.38076136
41VDR_24763502_ChIP-Seq_THP-1_Human1.37817107
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37155999
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37155999
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35059824
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27946504
46MYC_22102868_ChIP-Seq_BL_Human1.26801362
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.25825442
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.22610189
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19184349
50STAT3_23295773_ChIP-Seq_U87_Human1.17357798
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16970204
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14912542
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13962125
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13248969
55MAF_26560356_Chip-Seq_TH1_Human1.13111244
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11752324
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10619357
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.10345925
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.10254210
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10024383
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09888398
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.08707891
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07404300
64PU_27001747_Chip-Seq_BMDM_Mouse1.07179869
65ER_23166858_ChIP-Seq_MCF-7_Human1.06558072
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05952909
67SALL4_22934838_ChIP-ChIP_CD34+_Human1.05044759
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02342818
69E2F1_18555785_Chip-Seq_ESCs_Mouse0.99103258
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98382408
71RUNX1_22412390_ChIP-Seq_EML_Mouse0.96756501
72GATA2_19941826_ChIP-Seq_K562_Human0.95422813
73OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94067241
74UTX_26944678_Chip-Seq_JUKART_Human0.93979369
75NANOG_18555785_Chip-Seq_ESCs_Mouse0.92790334
76PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91079775
77AHR_22903824_ChIP-Seq_MCF-7_Human0.90989243
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90584457
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90070090
80FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89625559
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89141976
82ARNT_22903824_ChIP-Seq_MCF-7_Human0.89066930
83P300_18555785_Chip-Seq_ESCs_Mouse0.88733660
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.87386454
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86188353
86CMYC_18555785_Chip-Seq_ESCs_Mouse0.86113344
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85810041
88GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84893863
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84786488
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84668558
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.83803112
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83721738
93SMAD4_21799915_ChIP-Seq_A2780_Human0.83569854
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.82440306
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81744329
96P53_22387025_ChIP-Seq_ESCs_Mouse0.81588495
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81296815
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81200327
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.80537061
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.80433619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle4.34270351
2MP0000569_abnormal_digit_pigmentation4.07686844
3MP0008057_abnormal_DNA_replication3.46135570
4MP0001835_abnormal_antigen_presentation3.44116037
5MP0003724_increased_susceptibility_to3.07039272
6MP0001800_abnormal_humoral_immune2.99114094
7MP0008260_abnormal_autophagy2.98167653
8MP0003136_yellow_coat_color2.96836403
9MP0005075_abnormal_melanosome_morpholog2.93008268
10MP0000685_abnormal_immune_system2.85047155
11MP0003763_abnormal_thymus_physiology2.72117033
12MP0002166_altered_tumor_susceptibility2.65983855
13MP0003787_abnormal_imprinting2.58493591
14MP0002009_preneoplasia2.39046551
15MP0001790_abnormal_immune_system2.38124206
16MP0005387_immune_system_phenotype2.38124206
17MP0003303_peritoneal_inflammation2.36003712
18MP0002452_abnormal_antigen_presenting2.21879994
19MP0002723_abnormal_immune_serum2.21263936
20MP0005310_abnormal_salivary_gland2.18352051
21MP0002420_abnormal_adaptive_immunity2.17557755
22MP0005000_abnormal_immune_tolerance2.16422045
23MP0005671_abnormal_response_to2.11991089
24MP0001819_abnormal_immune_cell2.11179959
25MP0002419_abnormal_innate_immunity2.00305942
26MP0003436_decreased_susceptibility_to1.92581562
27MP0002398_abnormal_bone_marrow1.92251297
28MP0000716_abnormal_immune_system1.84013920
29MP0008877_abnormal_DNA_methylation1.81013313
30MP0005025_abnormal_response_to1.74549525
31MP0000689_abnormal_spleen_morphology1.70769837
32MP0003183_abnormal_peptide_metabolism1.68191715
33MP0002006_tumorigenesis1.66796528
34MP0002396_abnormal_hematopoietic_system1.63932767
35MP0002405_respiratory_system_inflammati1.60359362
36MP0002722_abnormal_immune_system1.57298391
37MP0005451_abnormal_body_composition1.53881165
38MP0000703_abnormal_thymus_morphology1.52950647
39MP0003045_fibrosis1.48692648
40MP0003221_abnormal_cardiomyocyte_apopto1.46326060
41MP0009785_altered_susceptibility_to1.42213275
42MP0000015_abnormal_ear_pigmentation1.41599524
43MP0004883_abnormal_blood_vessel1.41523102
44MP0008004_abnormal_stomach_pH1.41307363
45MP0002429_abnormal_blood_cell1.40270418
46MP0005408_hypopigmentation1.39318626
47MP0003866_abnormal_defecation1.32346041
48MP0002163_abnormal_gland_morphology1.27440358
49MP0003172_abnormal_lysosome_physiology1.27098188
50MP0003300_gastrointestinal_ulcer1.25375286
51MP0002132_abnormal_respiratory_system1.24894967
52MP0002148_abnormal_hypersensitivity_rea1.24741266
53MP0000013_abnormal_adipose_tissue1.23817741
54MP0005464_abnormal_platelet_physiology1.23801849
55MP0000371_diluted_coat_color1.23050281
56MP0003191_abnormal_cellular_cholesterol1.20158115
57MP0001845_abnormal_inflammatory_respons1.20053472
58MP0002653_abnormal_ependyma_morphology1.19890520
59MP0003656_abnormal_erythrocyte_physiolo1.16784837
60MP0003828_pulmonary_edema1.14631001
61MP0008961_abnormal_basal_metabolism1.11126309
62MP0004808_abnormal_hematopoietic_stem1.09155205
63MP0008995_early_reproductive_senescence1.08062766
64MP0004947_skin_inflammation1.06811859
65MP0000372_irregular_coat_pigmentation0.98223314
66MP0002095_abnormal_skin_pigmentation0.98212454
67MP0000427_abnormal_hair_cycle0.95910397
68MP0005379_endocrine/exocrine_gland_phen0.94783845
69MP0004484_altered_response_of0.94072985
70MP0002277_abnormal_respiratory_mucosa0.92638249
71MP0005174_abnormal_tail_pigmentation0.92225807
72MP0005397_hematopoietic_system_phenotyp0.90088238
73MP0001545_abnormal_hematopoietic_system0.90088238
74MP0000003_abnormal_adipose_tissue0.87424693
75MP0009115_abnormal_fat_cell0.87279878
76MP0005164_abnormal_response_to0.83512473
77MP0002019_abnormal_tumor_incidence0.78441354
78MP0010155_abnormal_intestine_physiology0.77816036
79MP0006082_CNS_inflammation0.77472545
80MP0003091_abnormal_cell_migration0.75912164
81MP0001186_pigmentation_phenotype0.75858805
82MP0001853_heart_inflammation0.73732298
83MP0005076_abnormal_cell_differentiation0.71989269
84MP0003690_abnormal_glial_cell0.71033776
85MP0001851_eye_inflammation0.70933399
86MP0008469_abnormal_protein_level0.66775739
87MP0009765_abnormal_xenobiotic_induced0.65127227
88MP0010307_abnormal_tumor_latency0.64978807
89MP0003195_calcinosis0.64532977
90MP0002933_joint_inflammation0.61963088
91MP0002136_abnormal_kidney_physiology0.61610140
92MP0010386_abnormal_urinary_bladder0.61168774
93MP0003121_genomic_imprinting0.61017807
94MP0001663_abnormal_digestive_system0.60679340
95MP0003632_abnormal_nervous_system0.60333164
96MP0002075_abnormal_coat/hair_pigmentati0.60168655
97MP0004130_abnormal_muscle_cell0.58728172
98MP0009764_decreased_sensitivity_to0.57413534
99MP0001533_abnormal_skeleton_physiology0.56089908
100MP0004142_abnormal_muscle_tone0.55548348

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.46573252
2Absent/shortened dynein arms (HP:0200106)5.46573252
3Recurrent bronchitis (HP:0002837)4.73358776
4Recurrent bacterial skin infections (HP:0005406)4.46974382
5T lymphocytopenia (HP:0005403)4.02718459
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.00935115
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.93708643
8Recurrent sinusitis (HP:0011108)3.84084138
9Recurrent fungal infections (HP:0002841)3.82399200
10Abnormality of T cell number (HP:0011839)3.78388668
11Recurrent cutaneous fungal infections (HP:0011370)3.71153905
12Chronic mucocutaneous candidiasis (HP:0002728)3.71153905
13Recurrent abscess formation (HP:0002722)3.70246263
14Abnormal ciliary motility (HP:0012262)3.68941510
15Bronchitis (HP:0012387)3.56656967
16Retrobulbar optic neuritis (HP:0100654)3.55986657
17Optic neuritis (HP:0100653)3.55986657
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.52330117
19Chronic hepatic failure (HP:0100626)3.52130459
20Panhypogammaglobulinemia (HP:0003139)3.49871844
21Recurrent viral infections (HP:0004429)3.46032928
22Gingivitis (HP:0000230)3.37297264
23Colitis (HP:0002583)3.30565851
24Orchitis (HP:0100796)3.26093548
25Abnormal respiratory motile cilium morphology (HP:0005938)3.24473770
26Abnormal respiratory epithelium morphology (HP:0012253)3.24473770
27Mediastinal lymphadenopathy (HP:0100721)3.23246669
28Eczematoid dermatitis (HP:0000976)3.19105054
29Meningitis (HP:0001287)3.18382249
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17986527
31Myositis (HP:0100614)3.17645836
32Recurrent skin infections (HP:0001581)3.15645490
33Abnormal respiratory motile cilium physiology (HP:0012261)3.11643182
34Hypoplasia of the thymus (HP:0000778)3.10699739
35Bronchiectasis (HP:0002110)3.10319240
36Encephalitis (HP:0002383)3.02941087
37Vasculitis (HP:0002633)3.01490428
38Chronic otitis media (HP:0000389)2.97584058
39Menstrual irregularities (HP:0000858)2.91560712
40Abnormality of the fingertips (HP:0001211)2.89748121
41Agammaglobulinemia (HP:0004432)2.89625306
42Gastrointestinal infarctions (HP:0005244)2.84987919
43IgA deficiency (HP:0002720)2.84283531
44Viral hepatitis (HP:0006562)2.83442713
45Lymphopenia (HP:0001888)2.82706666
46Autoimmune hemolytic anemia (HP:0001890)2.80175929
47Recurrent gram-negative bacterial infections (HP:0005420)2.75941406
48Abnormality of T cells (HP:0002843)2.75857826
49Recurrent pneumonia (HP:0006532)2.71325109
50Keratoconjunctivitis sicca (HP:0001097)2.69263360
51Chronic sinusitis (HP:0011109)2.63319472
52Inflammation of the large intestine (HP:0002037)2.59248358
53Abnormal hair whorl (HP:0010721)2.57314424
54Spontaneous hematomas (HP:0007420)2.55217468
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.54959304
56Thoracolumbar scoliosis (HP:0002944)2.53350561
57Recurrent otitis media (HP:0000403)2.52629393
58Keratoconjunctivitis (HP:0001096)2.52175455
59Elevated erythrocyte sedimentation rate (HP:0003565)2.51678925
60Tubulointerstitial nephritis (HP:0001970)2.51213067
61IgM deficiency (HP:0002850)2.48598652
62Cellulitis (HP:0100658)2.41978736
63Truncal obesity (HP:0001956)2.38674822
64Cone-rod dystrophy (HP:0000548)2.38443163
65Stomach cancer (HP:0012126)2.38310546
66Rhinitis (HP:0012384)2.37951866
67Nasal polyposis (HP:0100582)2.35954007
68Gastrointestinal inflammation (HP:0004386)2.34543715
69Thyroiditis (HP:0100646)2.23344671
70Slow saccadic eye movements (HP:0000514)2.21942731
71Arterial thrombosis (HP:0004420)2.21744026
72Recurrent lower respiratory tract infections (HP:0002783)2.20008112
73Hemoptysis (HP:0002105)2.18576494
74Chronic diarrhea (HP:0002028)2.18250250
75Abnormal rod and cone electroretinograms (HP:0008323)2.16947857
76Fatigue (HP:0012378)2.16567516
77Gastrointestinal stroma tumor (HP:0100723)2.16267650
78Chest pain (HP:0100749)2.16124353
79Papillary thyroid carcinoma (HP:0002895)2.15804128
80Genetic anticipation (HP:0003743)2.10191442
81Stomatitis (HP:0010280)2.10129503
82Gingival bleeding (HP:0000225)2.08430429
83Prominent nose (HP:0000448)2.05759633
84Aplasia/Hypoplasia of the macula (HP:0008059)2.05632685
85Submucous cleft hard palate (HP:0000176)2.00296558
86Leukocytosis (HP:0001974)1.98869341
87Pulmonary infiltrates (HP:0002113)1.98049290
88Acute hepatic failure (HP:0006554)1.94296415
89Abnormality of the peritoneum (HP:0002585)1.91217426
90Subacute progressive viral hepatitis (HP:0006572)1.91104538
91Aplasia/Hypoplasia affecting the retina (HP:0008061)1.88911292
92Lymphoma (HP:0002665)1.87966329
93Rhabdomyosarcoma (HP:0002859)1.87901502
94Chronic bronchitis (HP:0004469)1.86908881
95Obstructive lung disease (HP:0006536)1.86593784
96Chronic obstructive pulmonary disease (HP:0006510)1.86593784
97Constricted visual fields (HP:0001133)1.86311307
98Abnormality of B cell number (HP:0010975)1.85708599
99Eosinophilia (HP:0001880)1.85607097
100IgG deficiency (HP:0004315)1.81606854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.15487315
2BLK3.50151554
3IRAK43.30526316
4FRK2.75916306
5TYK22.34407057
6MAP2K32.20092277
7MAP4K12.18493849
8SGK22.14265882
9BTK2.03425526
10SYK1.97967969
11WNK11.95304344
12TAOK31.92543988
13MAP3K21.90933699
14IKBKE1.88274431
15CDK121.88231047
16GRK61.84731553
17CSK1.78342381
18TEC1.75191108
19JAK11.75069241
20SGK31.67481309
21IRAK11.61100481
22NLK1.55173169
23MAP3K141.51829606
24JAK31.48140463
25SGK2231.43794617
26SGK4941.43794617
27TXK1.42831031
28PIK3CG1.41976467
29MAP3K131.41709885
30FES1.38150681
31ITK1.38144850
32MST41.37017841
33PIM11.33890812
34TLK11.31083695
35IRAK21.29845506
36STK41.29662432
37FGR1.29071778
38JAK21.27264708
39LRRK21.26425694
40TNIK1.24804805
41BMPR21.23684361
42LYN1.21114762
43ACVR1B1.20293093
44FGFR31.13611530
45HCK1.12666418
46FGFR21.10737138
47ZAP701.07645215
48STK241.06549497
49MAP3K11.04139979
50MAP3K51.02911464
51PTK2B0.98022577
52MAP2K40.96068393
53SGK10.94773524
54PRKCQ0.93858248
55CAMKK20.90577077
56YES10.88145091
57IKBKB0.85755935
58MAP3K60.83779325
59EIF2AK30.79720501
60MELK0.78972809
61MAPK70.78742957
62STK160.76781173
63KSR20.76226282
64BRD40.75145235
65LCK0.74472556
66MAP3K30.74035093
67MARK20.73523045
68PDK10.72922690
69ERBB20.66935577
70DAPK20.66572048
71ZAK0.62419574
72STK100.59580867
73MAP3K70.56992473
74PRPF4B0.55341995
75CDK40.55132259
76CDK60.54323835
77STK110.54108153
78TRIB30.51560107
79STK38L0.50902038
80EGFR0.47692077
81TNK20.45668509
82CHUK0.45332667
83CSF1R0.45299542
84PAK30.45208487
85DYRK1A0.44467197
86MAPK110.43789421
87BRSK20.43502469
88STK380.41692699
89NEK60.40732829
90PDPK10.40317151
91RPS6KB10.38116711
92PRKAA20.37191470
93EPHB10.36850212
94KIT0.36779136
95MATK0.36514818
96CAMK40.36390740
97FYN0.36346371
98RPS6KB20.35495993
99BMPR1B0.35313452
100HIPK20.34160104

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.45807950
2Primary immunodeficiency_Homo sapiens_hsa053402.70566764
3Leishmaniasis_Homo sapiens_hsa051402.62221206
4Osteoclast differentiation_Homo sapiens_hsa043802.26911446
5T cell receptor signaling pathway_Homo sapiens_hsa046602.07385394
6Tuberculosis_Homo sapiens_hsa051522.04529037
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.03764323
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00678024
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96941293
10Allograft rejection_Homo sapiens_hsa053301.87705374
11Graft-versus-host disease_Homo sapiens_hsa053321.85810453
12Staphylococcus aureus infection_Homo sapiens_hsa051501.84586763
13Autoimmune thyroid disease_Homo sapiens_hsa053201.82778358
14Non-small cell lung cancer_Homo sapiens_hsa052231.81247998
15Measles_Homo sapiens_hsa051621.77064539
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75386768
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.73460068
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71268341
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69944374
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64693867
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64281428
22Hematopoietic cell lineage_Homo sapiens_hsa046401.62223888
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.52328273
24Influenza A_Homo sapiens_hsa051641.51643510
25Dorso-ventral axis formation_Homo sapiens_hsa043201.50759317
26Inositol phosphate metabolism_Homo sapiens_hsa005621.46321354
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46124011
28Toxoplasmosis_Homo sapiens_hsa051451.43961249
29Acute myeloid leukemia_Homo sapiens_hsa052211.37000000
30Hepatitis B_Homo sapiens_hsa051611.35780839
31TNF signaling pathway_Homo sapiens_hsa046681.34388934
32Type I diabetes mellitus_Homo sapiens_hsa049401.32545628
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29028991
34FoxO signaling pathway_Homo sapiens_hsa040681.24504488
35Asthma_Homo sapiens_hsa053101.23737371
36Systemic lupus erythematosus_Homo sapiens_hsa053221.22152158
37Prostate cancer_Homo sapiens_hsa052151.20956559
38Chemokine signaling pathway_Homo sapiens_hsa040621.15334667
39Antigen processing and presentation_Homo sapiens_hsa046121.12689625
40Herpes simplex infection_Homo sapiens_hsa051681.11152267
41Prolactin signaling pathway_Homo sapiens_hsa049171.10510218
42Endometrial cancer_Homo sapiens_hsa052131.08151838
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06175187
44Legionellosis_Homo sapiens_hsa051341.04538351
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.04410103
46Pancreatic cancer_Homo sapiens_hsa052121.03621383
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01939608
48Apoptosis_Homo sapiens_hsa042100.99436639
49Malaria_Homo sapiens_hsa051440.99393130
50Chronic myeloid leukemia_Homo sapiens_hsa052200.98901803
51Platelet activation_Homo sapiens_hsa046110.97698576
52Viral carcinogenesis_Homo sapiens_hsa052030.96625195
53Hepatitis C_Homo sapiens_hsa051600.94819832
54Colorectal cancer_Homo sapiens_hsa052100.92478664
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92175852
56VEGF signaling pathway_Homo sapiens_hsa043700.83632468
57Type II diabetes mellitus_Homo sapiens_hsa049300.82585672
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.81767418
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79625604
60Renal cell carcinoma_Homo sapiens_hsa052110.77867539
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76043287
62Alcoholism_Homo sapiens_hsa050340.74460751
63MAPK signaling pathway_Homo sapiens_hsa040100.70820798
64Viral myocarditis_Homo sapiens_hsa054160.67655867
65Long-term potentiation_Homo sapiens_hsa047200.67318673
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.67298804
67ErbB signaling pathway_Homo sapiens_hsa040120.66785846
68Taste transduction_Homo sapiens_hsa047420.65525094
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65342182
70Insulin resistance_Homo sapiens_hsa049310.65214354
71Phagosome_Homo sapiens_hsa041450.65177716
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64085931
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64054214
74GnRH signaling pathway_Homo sapiens_hsa049120.63434504
75Small cell lung cancer_Homo sapiens_hsa052220.63250632
76Choline metabolism in cancer_Homo sapiens_hsa052310.63135794
77mTOR signaling pathway_Homo sapiens_hsa041500.62875406
78Epstein-Barr virus infection_Homo sapiens_hsa051690.61661273
79Glioma_Homo sapiens_hsa052140.61506261
80ABC transporters_Homo sapiens_hsa020100.61416309
81Thyroid cancer_Homo sapiens_hsa052160.59068279
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.53354551
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52325789
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51148059
85HTLV-I infection_Homo sapiens_hsa051660.50949436
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50424185
87Cholinergic synapse_Homo sapiens_hsa047250.48481667
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.47644017
89Oxytocin signaling pathway_Homo sapiens_hsa049210.46246398
90HIF-1 signaling pathway_Homo sapiens_hsa040660.45722107
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45280006
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44464519
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43774856
94MicroRNAs in cancer_Homo sapiens_hsa052060.43600089
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43121626
96Estrogen signaling pathway_Homo sapiens_hsa049150.41060259
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39955134
98Regulation of autophagy_Homo sapiens_hsa041400.39928492
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39827978
100African trypanosomiasis_Homo sapiens_hsa051430.38173956

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