CENPV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.55888158
2fusion of sperm to egg plasma membrane (GO:0007342)7.20179988
3sperm-egg recognition (GO:0035036)6.87923163
4cell wall macromolecule catabolic process (GO:0016998)6.64932299
5cell wall macromolecule metabolic process (GO:0044036)6.64932299
6binding of sperm to zona pellucida (GO:0007339)6.64405422
7piRNA metabolic process (GO:0034587)6.61862391
8acrosome reaction (GO:0007340)6.46759947
9acrosome assembly (GO:0001675)6.40475802
10spermatid development (GO:0007286)6.38553907
11cilium or flagellum-dependent cell motility (GO:0001539)6.22258161
12cell-cell recognition (GO:0009988)6.02438784
13male meiosis (GO:0007140)6.01501799
14synaptonemal complex organization (GO:0070193)5.97456034
15synaptonemal complex assembly (GO:0007130)5.91533307
16motile cilium assembly (GO:0044458)5.77111408
17axonemal dynein complex assembly (GO:0070286)5.76212195
18epithelial cilium movement (GO:0003351)5.70998100
19multicellular organism reproduction (GO:0032504)5.41787300
20plasma membrane fusion (GO:0045026)5.39426465
21regulation of cilium movement (GO:0003352)5.12450604
22cilium movement (GO:0003341)4.95238726
23male meiosis I (GO:0007141)4.74866197
24DNA methylation involved in gamete generation (GO:0043046)4.74339089
25DNA deamination (GO:0045006)4.73403216
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.60997770
27ribosomal small subunit assembly (GO:0000028)4.57565454
28reproduction (GO:0000003)4.55486101
29chromosome organization involved in meiosis (GO:0070192)4.43869712
30sperm capacitation (GO:0048240)4.32719480
31chromosome condensation (GO:0030261)4.27180424
32spermatogenesis (GO:0007283)4.22857210
33male gamete generation (GO:0048232)4.22343967
34meiotic nuclear division (GO:0007126)4.21861641
35meiosis I (GO:0007127)4.19291546
36microtubule depolymerization (GO:0007019)4.17887861
37DNA packaging (GO:0006323)3.98057344
38chaperone-mediated protein complex assembly (GO:0051131)3.96405758
39single fertilization (GO:0007338)3.90591666
40gamete generation (GO:0007276)3.89764798
41germ cell development (GO:0007281)3.81203279
42fertilization (GO:0009566)3.79857617
43cellular process involved in reproduction in multicellular organism (GO:0022412)3.65557920
44organic cation transport (GO:0015695)3.58948115
45DNA unwinding involved in DNA replication (GO:0006268)3.53102871
46DNA strand elongation (GO:0022616)3.52052277
47negative regulation of inclusion body assembly (GO:0090084)3.50305492
48DNA replication-dependent nucleosome organization (GO:0034723)3.50175450
49DNA replication-dependent nucleosome assembly (GO:0006335)3.50175450
50viral transcription (GO:0019083)3.48712795
51seminiferous tubule development (GO:0072520)3.48547665
52meiotic cell cycle (GO:0051321)3.47840993
53kinetochore organization (GO:0051383)3.43029118
54* chromatin remodeling at centromere (GO:0031055)3.42121091
55CENP-A containing nucleosome assembly (GO:0034080)3.41637670
56protein localization to endoplasmic reticulum (GO:0070972)3.38801684
57translational termination (GO:0006415)3.35943396
58kinetochore assembly (GO:0051382)3.35683064
59telomere maintenance via semi-conservative replication (GO:0032201)3.34696353
60meiotic cell cycle process (GO:1903046)3.31734922
61behavioral response to nicotine (GO:0035095)3.30805342
62protein localization to chromosome, centromeric region (GO:0071459)3.27852486
63translational elongation (GO:0006414)3.25264055
64L-serine metabolic process (GO:0006563)3.25252265
65negative regulation of organelle assembly (GO:1902116)3.22855177
66regulation of inclusion body assembly (GO:0090083)3.22600729
67regulation of mitochondrial translation (GO:0070129)3.20048669
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.18510814
69chaperone-mediated protein transport (GO:0072321)3.16899139
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14288932
71regulation of microtubule-based movement (GO:0060632)3.12059932
72regulation of meiosis I (GO:0060631)3.12037256
73ribosomal large subunit biogenesis (GO:0042273)3.10630619
74glycerol ether metabolic process (GO:0006662)3.09144520
75DNA damage response, detection of DNA damage (GO:0042769)3.08558212
76multicellular organismal reproductive process (GO:0048609)3.07576144
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04748768
78histone exchange (GO:0043486)3.02279860
79gene silencing by RNA (GO:0031047)3.02106408
80maturation of SSU-rRNA (GO:0030490)3.00417398
81DNA replication-independent nucleosome assembly (GO:0006336)3.00338251
82DNA replication-independent nucleosome organization (GO:0034724)3.00338251
83negative regulation of RNA splicing (GO:0033119)2.96463555
84ribonucleoprotein complex biogenesis (GO:0022613)2.96091190
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95941235
86ATP synthesis coupled proton transport (GO:0015986)2.95941235
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95329978
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89683251
89spermatid nucleus differentiation (GO:0007289)2.87960320
90interferon-gamma secretion (GO:0072643)2.87825607
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87619804
92DNA replication initiation (GO:0006270)2.86660434
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85251290
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.85251290
95NADH dehydrogenase complex assembly (GO:0010257)2.85251290
96ether metabolic process (GO:0018904)2.83748045
97synapsis (GO:0007129)2.83737789
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82930825
99translational initiation (GO:0006413)2.81667630
100protein complex localization (GO:0031503)2.81601947
101nuclear-transcribed mRNA catabolic process (GO:0000956)2.81199054
102pyrimidine nucleobase catabolic process (GO:0006208)2.80742710
103cellular protein complex disassembly (GO:0043624)2.80554090
104proline biosynthetic process (GO:0006561)2.80553873
105negative regulation of mRNA processing (GO:0050686)2.80394205
106mitochondrial respiratory chain complex assembly (GO:0033108)2.79088399
107translesion synthesis (GO:0019985)2.78837694
108intra-S DNA damage checkpoint (GO:0031573)2.78770036
109cellular component biogenesis (GO:0044085)2.78433195
110mitotic sister chromatid segregation (GO:0000070)2.78047395
111replication fork processing (GO:0031297)2.77422936
112protein complex biogenesis (GO:0070271)2.76128912
113mitotic recombination (GO:0006312)2.75371795
114regulation of histone H3-K9 methylation (GO:0051570)2.75206306
115mitotic sister chromatid cohesion (GO:0007064)2.74226048
116telomere maintenance via recombination (GO:0000722)2.74036081
117ribosomal small subunit biogenesis (GO:0042274)2.73982645
118ventricular system development (GO:0021591)2.73639704
119protein complex disassembly (GO:0043241)2.72773172
120gene silencing (GO:0016458)2.72690987
121regulation of spindle checkpoint (GO:0090231)2.72386696
122pyrimidine nucleotide catabolic process (GO:0006244)2.70935829
123viral life cycle (GO:0019058)2.70719386
124protein targeting to ER (GO:0045047)2.70362816
125translation (GO:0006412)2.70316908
126folic acid-containing compound biosynthetic process (GO:0009396)2.70286701
127calcium ion-dependent exocytosis (GO:0017156)2.70022099
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68820648
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.68738879
130mRNA catabolic process (GO:0006402)2.68033670
131UTP biosynthetic process (GO:0006228)2.65263729
132spliceosomal snRNP assembly (GO:0000387)2.64879546
133DNA strand elongation involved in DNA replication (GO:0006271)2.63395976
134left/right pattern formation (GO:0060972)2.62199411
135single strand break repair (GO:0000012)2.59927133
136rRNA processing (GO:0006364)2.59339614
137microtubule severing (GO:0051013)2.59176011
138cotranslational protein targeting to membrane (GO:0006613)2.58569542
139DNA replication checkpoint (GO:0000076)2.58345093
140protein localization to kinetochore (GO:0034501)2.58185752
141UTP metabolic process (GO:0046051)2.57541494
142pseudouridine synthesis (GO:0001522)2.57426604
143pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.56634899
144sister chromatid segregation (GO:0000819)2.56542636
145cell recognition (GO:0008037)2.55995835
146DNA strand renaturation (GO:0000733)2.55308594
147GTP biosynthetic process (GO:0006183)2.55271455
148RNA catabolic process (GO:0006401)2.55022476
149pteridine-containing compound biosynthetic process (GO:0042559)2.54836862
150macromolecular complex disassembly (GO:0032984)2.54778150
151DNA conformation change (GO:0071103)2.54386638
152CTP metabolic process (GO:0046036)2.54304010
153CTP biosynthetic process (GO:0006241)2.54304010
154establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54289145
155establishment of integrated proviral latency (GO:0075713)2.53495253
156rRNA metabolic process (GO:0016072)2.50951048
157serine family amino acid biosynthetic process (GO:0009070)2.49568827
158regulation of gene silencing by RNA (GO:0060966)2.49014299
159regulation of posttranscriptional gene silencing (GO:0060147)2.49014299
160regulation of gene silencing by miRNA (GO:0060964)2.49014299
161* chromatin assembly or disassembly (GO:0006333)2.48485826
162pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.47559588
163pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45866035
164mitotic chromosome condensation (GO:0007076)2.45316775
165DNA topological change (GO:0006265)2.44775469
166somatic hypermutation of immunoglobulin genes (GO:0016446)2.44471047
167somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44471047
168protein targeting to membrane (GO:0006612)2.43909132
169ATP-dependent chromatin remodeling (GO:0043044)2.43118167
170protein neddylation (GO:0045116)2.43008067
171protein K6-linked ubiquitination (GO:0085020)2.42345552
172protein-cofactor linkage (GO:0018065)2.40782200
173nucleosome disassembly (GO:0006337)2.40015146
174protein-DNA complex disassembly (GO:0032986)2.40015146
175regulation of nuclear cell cycle DNA replication (GO:0033262)2.37951050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.39712085
2E2F7_22180533_ChIP-Seq_HELA_Human5.42869501
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.25135567
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.09567996
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69034233
6EZH2_22144423_ChIP-Seq_EOC_Human2.63903932
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57243335
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51879965
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50036189
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39135023
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33783076
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33720466
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32703794
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19668365
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19288759
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96972463
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93492682
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90037789
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89230475
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84712557
21MYC_18940864_ChIP-ChIP_HL60_Human1.84044019
22IRF1_19129219_ChIP-ChIP_H3396_Human1.81023276
23SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80965160
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.77923539
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77001960
26XRN2_22483619_ChIP-Seq_HELA_Human1.75546520
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73673642
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69619732
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66738124
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66700139
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.65929970
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63445786
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.61496475
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61047325
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.59335583
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58721074
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56924937
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56812979
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55206838
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53519913
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.53192900
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51119231
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47400868
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.46802155
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.45651832
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.40198789
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39441379
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39309682
49DCP1A_22483619_ChIP-Seq_HELA_Human1.39053595
50ZNF263_19887448_ChIP-Seq_K562_Human1.36698501
51* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36406407
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33965215
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32748071
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31558882
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31214779
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.31040790
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30708817
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29998000
59GABP_19822575_ChIP-Seq_HepG2_Human1.29721132
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29684974
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29298803
62KDM5A_27292631_Chip-Seq_BREAST_Human1.26741604
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25784951
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.25751474
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25602210
66TTF2_22483619_ChIP-Seq_HELA_Human1.22029432
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.21581738
68FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21112421
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19782066
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18617749
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18179190
72GATA3_21867929_ChIP-Seq_CD8_Mouse1.17400583
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17038475
74* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16088356
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15571970
76* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14409238
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14011362
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13844949
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13286836
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12601676
81RNF2_27304074_Chip-Seq_NSC_Mouse1.12283103
82RARA_24833708_ChIP-Seq_LIVER_Mouse1.11171203
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11078344
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10778691
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.10260918
86AR_21909140_ChIP-Seq_LNCAP_Human1.10112941
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09521664
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07639400
89ELK1_19687146_ChIP-ChIP_HELA_Human1.07557504
90* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07122940
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05743435
92VDR_23849224_ChIP-Seq_CD4+_Human1.05312605
93PHF8_20622854_ChIP-Seq_HELA_Human1.05250018
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05139034
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04612341
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04328916
97FOXP3_21729870_ChIP-Seq_TREG_Human1.03180097
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.03179948
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02378097
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.01650032
101FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01171898
102CIITA_25753668_ChIP-Seq_RAJI_Human1.00686396
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99976709
104GABP_17652178_ChIP-ChIP_JURKAT_Human0.99123126
105KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98796217
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98730409
107P53_21459846_ChIP-Seq_SAOS-2_Human0.98669841
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98065955
109NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97677021
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97487910
111THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96824444
112POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96159835
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.95801571
114EWS_26573619_Chip-Seq_HEK293_Human0.94476585
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93991727
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.93286405
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91967136
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.91574608
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91557007
120* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90962999
121BCOR_27268052_Chip-Seq_Bcells_Human0.90743441
122JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90672818
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.89460844
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.89348120
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.89090858
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89034372
127STAT1_20625510_ChIP-Seq_HELA_Human0.88846819
128SPI1_26923725_Chip-Seq_HPCs_Mouse0.87695700
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87135046
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87113375
131P68_20966046_ChIP-Seq_HELA_Human0.86703043
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86072467
133FUS_26573619_Chip-Seq_HEK293_Human0.85850415
134E2F1_20622854_ChIP-Seq_HELA_Human0.85425754
135ZNF274_21170338_ChIP-Seq_K562_Hela0.83329562
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83074693
137* WDR5_24793694_ChIP-Seq_LNCAP_Human0.83024893
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.83016771
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.82627750
140REST_21632747_ChIP-Seq_MESCs_Mouse0.80433357
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80201661
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79638189
143IGF1R_20145208_ChIP-Seq_DFB_Human0.78802721
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76575843
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76459668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.78468010
2MP0008877_abnormal_DNA_methylation4.13392613
3MP0006292_abnormal_olfactory_placode4.07158397
4MP0001929_abnormal_gametogenesis4.03314837
5MP0003698_abnormal_male_reproductive3.92557764
6MP0002653_abnormal_ependyma_morphology3.52449956
7MP0003283_abnormal_digestive_organ3.03497003
8MP0002210_abnormal_sex_determination3.02881812
9MP0003693_abnormal_embryo_hatching2.89198590
10MP0003122_maternal_imprinting2.75514922
11MP0004957_abnormal_blastocyst_morpholog2.68647392
12MP0001145_abnormal_male_reproductive2.66586308
13MP0002139_abnormal_hepatobiliary_system2.59795267
14MP0003111_abnormal_nucleus_morphology2.52447328
15MP0005360_urolithiasis2.50342558
16MP0010094_abnormal_chromosome_stability2.47129734
17MP0000653_abnormal_sex_gland2.35396955
18MP0008789_abnormal_olfactory_epithelium2.34541592
19MP0002161_abnormal_fertility/fecundity2.31612156
20MP0010030_abnormal_orbit_morphology2.27243051
21MP0005499_abnormal_olfactory_system2.19137477
22MP0005394_taste/olfaction_phenotype2.19137477
23MP0008057_abnormal_DNA_replication2.15677774
24MP0000566_synostosis2.07381024
25MP0003121_genomic_imprinting2.04673687
26MP0003806_abnormal_nucleotide_metabolis2.03144318
27MP0003646_muscle_fatigue2.02098539
28MP0000049_abnormal_middle_ear1.99093524
29MP0005085_abnormal_gallbladder_physiolo1.91910644
30MP0001529_abnormal_vocalization1.90169397
31MP0003123_paternal_imprinting1.82729196
32MP0003077_abnormal_cell_cycle1.78045528
33MP0004233_abnormal_muscle_weight1.77347777
34MP0008058_abnormal_DNA_repair1.74483910
35MP0002938_white_spotting1.74480933
36MP0002160_abnormal_reproductive_system1.71051656
37MP0000778_abnormal_nervous_system1.70199805
38MP0005365_abnormal_bile_salt1.70162865
39MP0003937_abnormal_limbs/digits/tail_de1.65672872
40MP0003880_abnormal_central_pattern1.56827172
41MP0002233_abnormal_nose_morphology1.49968941
42MP0001188_hyperpigmentation1.48721555
43MP0000631_abnormal_neuroendocrine_gland1.48380823
44MP0003136_yellow_coat_color1.46454800
45MP0005670_abnormal_white_adipose1.46136480
46MP0003315_abnormal_perineum_morphology1.46044100
47MP0000462_abnormal_digestive_system1.43148030
48MP0006036_abnormal_mitochondrial_physio1.43017712
49MP0001286_abnormal_eye_development1.41530152
50MP0001730_embryonic_growth_arrest1.39708636
51MP0003890_abnormal_embryonic-extraembry1.36710956
52MP0002697_abnormal_eye_size1.36522794
53MP0003252_abnormal_bile_duct1.31797432
54MP0003938_abnormal_ear_development1.31543289
55MP0002163_abnormal_gland_morphology1.30443348
56MP0003567_abnormal_fetal_cardiomyocyte1.30268145
57MP0010234_abnormal_vibrissa_follicle1.28990842
58MP0003119_abnormal_digestive_system1.27878702
59MP0001346_abnormal_lacrimal_gland1.25332903
60MP0006276_abnormal_autonomic_nervous1.24070021
61MP0008932_abnormal_embryonic_tissue1.24020124
62MP0002249_abnormal_larynx_morphology1.20960110
63MP0003718_maternal_effect1.19232546
64MP0009379_abnormal_foot_pigmentation1.17965471
65MP0005423_abnormal_somatic_nervous1.17674129
66MP0008875_abnormal_xenobiotic_pharmacok1.17543480
67MP0000490_abnormal_crypts_of1.16873166
68MP0002736_abnormal_nociception_after1.15254138
69MP0002184_abnormal_innervation1.15050493
70MP0000955_abnormal_spinal_cord1.14769191
71MP0004264_abnormal_extraembryonic_tissu1.14416591
72MP0005645_abnormal_hypothalamus_physiol1.14059926
73MP0006035_abnormal_mitochondrial_morpho1.13272490
74MP0008995_early_reproductive_senescence1.13046034
75MP0003787_abnormal_imprinting1.08794095
76MP0003942_abnormal_urinary_system1.07325018
77MP0002234_abnormal_pharynx_morphology1.06234337
78MP0003755_abnormal_palate_morphology1.05920626
79MP0000350_abnormal_cell_proliferation1.02613243
80MP0002557_abnormal_social/conspecific_i1.02252820
81MP0005389_reproductive_system_phenotype1.01639115
82MP0004019_abnormal_vitamin_homeostasis1.01344867
83MP0002752_abnormal_somatic_nervous1.00780651
84MP0004147_increased_porphyrin_level1.00686826
85MP0003385_abnormal_body_wall0.99818265
86MP0001984_abnormal_olfaction0.99507492
87MP0002638_abnormal_pupillary_reflex0.99467804
88MP0005187_abnormal_penis_morphology0.99418451
89MP0001485_abnormal_pinna_reflex0.98414215
90MP0002092_abnormal_eye_morphology0.97154711
91MP0010307_abnormal_tumor_latency0.96924712
92MP0002751_abnormal_autonomic_nervous0.96832008
93MP0000537_abnormal_urethra_morphology0.96777673
94MP0002152_abnormal_brain_morphology0.96713861
95MP0004142_abnormal_muscle_tone0.95947589
96MP0001968_abnormal_touch/_nociception0.95883912
97MP0002085_abnormal_embryonic_tissue0.95105666
98MP0003786_premature_aging0.94438513
99MP0002111_abnormal_tail_morphology0.93919361
100MP0001697_abnormal_embryo_size0.93715555
101MP0002084_abnormal_developmental_patter0.93043544
102MP0005380_embryogenesis_phenotype0.92553581
103MP0001672_abnormal_embryogenesis/_devel0.92553581
104MP0005646_abnormal_pituitary_gland0.91753549
105MP0002080_prenatal_lethality0.91706966
106MP0000026_abnormal_inner_ear0.91294473
107MP0005666_abnormal_adipose_tissue0.89813112
108MP0005636_abnormal_mineral_homeostasis0.89217595
109MP0005266_abnormal_metabolism0.88618549
110MP0005377_hearing/vestibular/ear_phenot0.87675845
111MP0003878_abnormal_ear_physiology0.87675845
112MP0000358_abnormal_cell_content/0.86556136
113MP0005195_abnormal_posterior_eye0.85941078
114MP0000428_abnormal_craniofacial_morphol0.85781592
115MP0005391_vision/eye_phenotype0.85153248
116MP0002272_abnormal_nervous_system0.84256632
117MP0004742_abnormal_vestibular_system0.84049486
118MP0003115_abnormal_respiratory_system0.83558602
119MP0001765_abnormal_ion_homeostasis0.83413996
120MP0009053_abnormal_anal_canal0.82440193
121MP0001666_abnormal_nutrient_absorption0.82259118
122MP0002116_abnormal_craniofacial_bone0.81872478
123MP0002882_abnormal_neuron_morphology0.80546885
124MP0005647_abnormal_sex_gland0.79357213
125MP0004859_abnormal_synaptic_plasticity0.79004606
126MP0000313_abnormal_cell_death0.78451670
127MP0001764_abnormal_homeostasis0.78044627
128MP0009745_abnormal_behavioral_response0.77558125
129MP0003699_abnormal_female_reproductive0.77014220
130MP0004133_heterotaxia0.76926900
131MP0005551_abnormal_eye_electrophysiolog0.76827218
132MP0003635_abnormal_synaptic_transmissio0.76216629
133MP0002086_abnormal_extraembryonic_tissu0.74949301
134MP0010329_abnormal_lipoprotein_level0.74261118
135MP0003984_embryonic_growth_retardation0.73473976
136MP0008872_abnormal_physiological_respon0.72386829
137MP0000477_abnormal_intestine_morphology0.70416296
138MP0002088_abnormal_embryonic_growth/wei0.70280863
139MP0001119_abnormal_female_reproductive0.69639109
140MP0006072_abnormal_retinal_apoptosis0.66472653
141MP0008007_abnormal_cellular_replicative0.66221987
142MP0005319_abnormal_enzyme/_coenzyme0.66145537
143MP0002822_catalepsy0.65778941
144MP0002132_abnormal_respiratory_system0.65157993
145MP0005381_digestive/alimentary_phenotyp0.64934712
146MP0001944_abnormal_pancreas_morphology0.64658546
147MP0000678_abnormal_parathyroid_gland0.64448065
148MP0004185_abnormal_adipocyte_glucose0.60900499
149MP0002269_muscular_atrophy0.59163462
150MP0004197_abnormal_fetal_growth/weight/0.59067704
151MP0001293_anophthalmia0.58946115
152MP0002019_abnormal_tumor_incidence0.56133390
153MP0004043_abnormal_pH_regulation0.55299040
154MP0002102_abnormal_ear_morphology0.54420066
155MP0010352_gastrointestinal_tract_polyps0.54305220
156MP0008004_abnormal_stomach_pH0.54288481
157MP0003861_abnormal_nervous_system0.54193180
158MP0005332_abnormal_amino_acid0.53161714
159MP0002928_abnormal_bile_duct0.52133240
160MP0001663_abnormal_digestive_system0.51641651
161MP0002282_abnormal_trachea_morphology0.51325387
162MP0000613_abnormal_salivary_gland0.51269413
163MP0005451_abnormal_body_composition0.51211947

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.80541607
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.75625072
3Absent/shortened dynein arms (HP:0200106)7.75625072
4Abnormal respiratory motile cilium physiology (HP:0012261)6.46799350
5Abnormal respiratory motile cilium morphology (HP:0005938)5.75747096
6Abnormal respiratory epithelium morphology (HP:0012253)5.75747096
7Rhinitis (HP:0012384)5.11639475
8Chronic bronchitis (HP:0004469)5.11096520
9Abnormal ciliary motility (HP:0012262)5.07918583
10Infertility (HP:0000789)5.05927303
11Male infertility (HP:0003251)4.47973412
12Nasal polyposis (HP:0100582)4.01396431
13Abnormality of cells of the erythroid lineage (HP:0012130)3.33569076
14Bronchiectasis (HP:0002110)3.22138755
15Abnormal spermatogenesis (HP:0008669)3.14846113
16Abnormal number of erythroid precursors (HP:0012131)3.11630350
17Colon cancer (HP:0003003)3.07381982
18Impulsivity (HP:0100710)3.02232786
19Abnormality of the nasal mucosa (HP:0000433)2.98087802
20Abnormality of the lower motor neuron (HP:0002366)2.88170205
21Abnormality of the labia minora (HP:0012880)2.84793488
22Septo-optic dysplasia (HP:0100842)2.82114314
23Bronchitis (HP:0012387)2.75366606
24Reticulocytopenia (HP:0001896)2.67928241
25Nephronophthisis (HP:0000090)2.67592479
26Anophthalmia (HP:0000528)2.56149574
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55602696
28Azoospermia (HP:0000027)2.53464929
29Abnormal number of incisors (HP:0011064)2.52160334
30High anterior hairline (HP:0009890)2.51639596
31Rib fusion (HP:0000902)2.49410604
32Birth length less than 3rd percentile (HP:0003561)2.47502347
33Chromsome breakage (HP:0040012)2.47120853
34Gonadotropin excess (HP:0000837)2.45535283
35Ectopic kidney (HP:0000086)2.38925197
36Meckel diverticulum (HP:0002245)2.37786538
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33450089
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33450089
39Triphalangeal thumb (HP:0001199)2.30677382
40Posterior subcapsular cataract (HP:0007787)2.29565747
41Cholecystitis (HP:0001082)2.28989528
42Abnormal gallbladder physiology (HP:0012438)2.28989528
43Patellar aplasia (HP:0006443)2.27520852
44Horseshoe kidney (HP:0000085)2.24451590
45Cerebellar dysplasia (HP:0007033)2.23627898
46Hepatoblastoma (HP:0002884)2.22325943
47Ependymoma (HP:0002888)2.21003344
4811 pairs of ribs (HP:0000878)2.18164432
49Aplasia/Hypoplasia of the patella (HP:0006498)2.17275886
50Pancreatic fibrosis (HP:0100732)2.13580108
51Abnormality of midbrain morphology (HP:0002418)2.13085645
52Molar tooth sign on MRI (HP:0002419)2.13085645
53Macrocytic anemia (HP:0001972)2.12790012
54Abnormality of the anterior horn cell (HP:0006802)2.11823659
55Degeneration of anterior horn cells (HP:0002398)2.11823659
56Sclerocornea (HP:0000647)2.11604126
57Pallor (HP:0000980)2.09152823
58Esophageal atresia (HP:0002032)2.05436941
59Abnormality of cochlea (HP:0000375)2.03669272
60Breast hypoplasia (HP:0003187)2.02362900
61Ventricular fibrillation (HP:0001663)2.01002931
62Microvesicular hepatic steatosis (HP:0001414)2.00843364
63Retinal dysplasia (HP:0007973)1.99348592
64Increased muscle lipid content (HP:0009058)1.99111735
65Optic nerve hypoplasia (HP:0000609)1.98612038
66Duplication of thumb phalanx (HP:0009942)1.98011681
67Increased intramyocellular lipid droplets (HP:0012240)1.95891395
68Maternal diabetes (HP:0009800)1.95812357
69Amyotrophic lateral sclerosis (HP:0007354)1.95332951
70Progressive macrocephaly (HP:0004481)1.95281319
71Malnutrition (HP:0004395)1.95174853
72Myokymia (HP:0002411)1.93792033
73Absent thumb (HP:0009777)1.92869226
74Acute encephalopathy (HP:0006846)1.92039663
75Pendular nystagmus (HP:0012043)1.91934884
76Bilateral microphthalmos (HP:0007633)1.91709583
77Anencephaly (HP:0002323)1.91439302
78Abnormality of the aortic arch (HP:0012303)1.91170566
79Oral leukoplakia (HP:0002745)1.90309753
80Absent radius (HP:0003974)1.89946498
81Lipid accumulation in hepatocytes (HP:0006561)1.89909121
82Missing ribs (HP:0000921)1.89788569
83Recurrent otitis media (HP:0000403)1.89740527
84Pancreatic cysts (HP:0001737)1.88811737
85Absent forearm bone (HP:0003953)1.88090570
86Aplasia involving forearm bones (HP:0009822)1.88090570
87Type II lissencephaly (HP:0007260)1.87752639
88Preaxial hand polydactyly (HP:0001177)1.86914348
89Abnormal lung lobation (HP:0002101)1.86565965
90Hypobetalipoproteinemia (HP:0003563)1.86457500
91Tubulointerstitial nephritis (HP:0001970)1.85434402
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85388330
93Absent septum pellucidum (HP:0001331)1.85224416
94Increased hepatocellular lipid droplets (HP:0006565)1.84573009
95Rhabdomyosarcoma (HP:0002859)1.84248766
96Optic nerve coloboma (HP:0000588)1.83871723
97True hermaphroditism (HP:0010459)1.83848403
98Abnormality of the renal medulla (HP:0100957)1.80543758
99Morphological abnormality of the inner ear (HP:0011390)1.80424116
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79915698
101Lissencephaly (HP:0001339)1.79550422
102Holoprosencephaly (HP:0001360)1.79354322
103Oligodactyly (HP:0012165)1.79030433
104Partial duplication of thumb phalanx (HP:0009944)1.79020404
105Biliary tract neoplasm (HP:0100574)1.78876842
106Medulloblastoma (HP:0002885)1.78648168
107Abnormality of the 4th metacarpal (HP:0010012)1.78557980
108Hyperglycinuria (HP:0003108)1.78506179
109Hypoplasia of the radius (HP:0002984)1.77218478
110Abnormality of the preputium (HP:0100587)1.77147044
111Mitochondrial inheritance (HP:0001427)1.74980280
112Abnormality of glycine metabolism (HP:0010895)1.73884347
113Abnormality of serine family amino acid metabolism (HP:0010894)1.73884347
114Hemivertebrae (HP:0002937)1.73663646
115Abnormal mitochondria in muscle tissue (HP:0008316)1.73276343
116Neoplasm of striated muscle (HP:0009728)1.72319577
117Oligodactyly (hands) (HP:0001180)1.71924392
118Depressed nasal ridge (HP:0000457)1.71542359
119Secondary amenorrhea (HP:0000869)1.71193764
120Partial agenesis of the corpus callosum (HP:0001338)1.70216508
121Medial flaring of the eyebrow (HP:0010747)1.70129712
122Short thumb (HP:0009778)1.70068420
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69826005
124Acute necrotizing encephalopathy (HP:0006965)1.69688717
125Hypoplastic pelvis (HP:0008839)1.69276420
126Abnormality of chromosome stability (HP:0003220)1.68799382
127Aplasia/hypoplasia of the humerus (HP:0006507)1.68444840
128Myoglobinuria (HP:0002913)1.68262126
129Abnormality of the carotid arteries (HP:0005344)1.66708411
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.66615961
131Cortical dysplasia (HP:0002539)1.66471805
132Increased serum lactate (HP:0002151)1.66199665
133Intestinal atresia (HP:0011100)1.65184451
134Abnormal hemoglobin (HP:0011902)1.64646291
135Increased CSF lactate (HP:0002490)1.64582565
136Abnormality of reticulocytes (HP:0004312)1.63450493
137Abnormality of pyrimidine metabolism (HP:0004353)1.63272622
138Dandy-Walker malformation (HP:0001305)1.63068927
139Irregular epiphyses (HP:0010582)1.62993170
140Short humerus (HP:0005792)1.62389908
141Postaxial foot polydactyly (HP:0001830)1.62207748
142Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61620392
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.61419754
144Partial duplication of the phalanx of hand (HP:0009999)1.60579751
145Gait imbalance (HP:0002141)1.59560484
146Hypoplasia of the pons (HP:0012110)1.58778709
147Abnormality of DNA repair (HP:0003254)1.58718133
148Sex reversal (HP:0012245)1.57622623
149Abnormal sex determination (HP:0012244)1.57622623
150Recurrent sinusitis (HP:0011108)1.57129118
151Heterotopia (HP:0002282)1.56817792
152Short ribs (HP:0000773)1.56473017
153Subcapsular cataract (HP:0000523)1.55763626
154Hepatocellular necrosis (HP:0001404)1.55479622
155Supernumerary spleens (HP:0009799)1.54670454
156Tubulointerstitial abnormality (HP:0001969)1.54639785
157Hepatic necrosis (HP:0002605)1.53233058
158Impaired proprioception (HP:0010831)1.51917443
159Rhabdomyolysis (HP:0003201)1.51100284
160Late onset (HP:0003584)1.50921211
161Premature ovarian failure (HP:0008209)1.50283725
162Cerebral edema (HP:0002181)1.50154191
163Adenoma sebaceum (HP:0009720)1.49598052
164Angiofibromas (HP:0010615)1.49598052
165Hyperinsulinemic hypoglycemia (HP:0000825)1.49315744
166Facial cleft (HP:0002006)1.49314323
167Abnormality of the ileum (HP:0001549)1.49206430
168Aplasia/Hypoplasia of the sacrum (HP:0008517)1.48972983
169Emotional lability (HP:0000712)1.48439874
170Selective tooth agenesis (HP:0001592)1.46630899
171Acanthocytosis (HP:0001927)1.45102166
172Hyperglycinemia (HP:0002154)1.44392515
173Abnormality of abdominal situs (HP:0011620)1.44008182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.83993694
2PDK45.83993694
3TAOK34.02039969
4ICK3.75700346
5PRKD33.64423458
6TESK13.60310539
7TLK13.47052468
8PDK23.32734583
9ZAK2.96537565
10NEK22.75543269
11VRK22.58992105
12CDC72.55303742
13PASK2.23431681
14PLK42.06986976
15EEF2K1.98327815
16TTK1.95490390
17WEE11.73742412
18MKNK11.68023506
19CDK191.67098700
20CASK1.67054453
21EPHA41.65657030
22MAP2K71.62848732
23MKNK21.57764355
24PNCK1.49908908
25EPHB21.49018003
26WNK31.48839930
27MAP3K101.43147752
28STK381.41933011
29PLK31.41432310
30STK38L1.38044618
31TNIK1.38025011
32NME21.36676672
33CDK121.31516783
34WNK41.28584981
35PLK11.28064120
36BUB11.25939529
37TAF11.25115135
38MARK11.24892128
39MAP3K61.23719416
40PKN21.22522284
41CSNK1G31.21528464
42CHEK21.21410755
43LMTK21.17439111
44DYRK31.17428989
45CSNK1G11.14677127
46CSNK1G21.11893466
47BCKDK1.11891949
48PINK11.11712324
49MAP4K21.06709019
50NTRK21.04756982
51NUAK11.04125707
52AURKB0.99012457
53CSNK1A1L0.96907889
54CAMK1D0.96798466
55CAMK1G0.95811544
56CDK80.93623113
57ATR0.93164354
58DYRK1B0.91336031
59CDK70.90987799
60PRKCG0.90142567
61PTK2B0.89078140
62TRIB30.88787438
63TYRO30.88291411
64UHMK10.87336560
65BRAF0.87126664
66CDK40.85210088
67BCR0.84842412
68AURKA0.84556065
69BMPR1B0.81258816
70CHEK10.79744975
71RPS6KA50.78260522
72CCNB10.77780723
73BRSK20.76534017
74TAOK10.76529515
75TESK20.72692829
76MAPK130.72376205
77MAP2K60.70931374
78SRPK10.68783455
79TSSK60.67986063
80MINK10.67698748
81MAPK110.67628780
82SCYL20.67403043
83KSR20.65063094
84ATM0.64257036
85MAP2K20.63556219
86MAPKAPK30.61524354
87FGFR20.61469679
88STK390.60556935
89MAPKAPK50.59944669
90STK160.59367338
91RPS6KB20.58332728
92NEK10.57295681
93TRIM280.56862112
94PAK10.56384041
95MAPK150.56295141
96PRKDC0.55663313
97INSRR0.53634664
98GRK10.53189231
99ILK0.52644493
100MAP3K40.51565205
101CDK140.51345767
102MTOR0.50205796
103PBK0.50004568
104DYRK1A0.49970087
105VRK10.49789897
106CDK20.49188763
107ADRBK20.48897608
108PDK10.48393415
109CDK30.46256905
110MAP3K80.45613654
111ERBB40.45591686
112ACVR1B0.44890086
113EPHA20.44859093
114STK110.44722730
115RAF10.43685557
116CSNK2A10.43616187
117RPS6KA40.43583797
118MAP3K90.43158670
119NME10.42959809
120CAMK40.42276829
121CSNK2A20.42080101
122PAK40.42019872
123SMG10.41417583
124CDK90.41323498
125EIF2AK10.40090904
126CAMK10.40037089
127CAMKK10.39364999
128CSNK1A10.38870181
129PLK20.37633406
130KSR10.37264086
131MAP3K110.37241681
132AKT20.36074793
133AKT30.34894363
134PRKAA10.32282434
135GRK60.31399486
136STK30.31200034
137CDK11A0.29636279
138RPS6KB10.29397389
139RPS6KA10.29158235
140LATS20.28974346
141PRKG20.28911967
142FRK0.28345232
143FLT30.28148353
144PRKCI0.27853014
145DYRK20.27332673
146CDK150.27280009
147CDK10.26728190
148CSNK1E0.26129047
149MAP2K40.25284728
150ERBB20.24900882
151CDK180.23312581
152BRSK10.22053535

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.05723843
2DNA replication_Homo sapiens_hsa030303.04510269
3Mismatch repair_Homo sapiens_hsa034302.74157794
4Pyruvate metabolism_Homo sapiens_hsa006202.65658511
5Selenocompound metabolism_Homo sapiens_hsa004502.48725793
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.44898181
7Homologous recombination_Homo sapiens_hsa034402.33189910
8Huntingtons disease_Homo sapiens_hsa050162.18373753
9RNA transport_Homo sapiens_hsa030131.98955350
10Sulfur relay system_Homo sapiens_hsa041221.98079035
11Propanoate metabolism_Homo sapiens_hsa006401.93671925
12Fanconi anemia pathway_Homo sapiens_hsa034601.93623694
13Oxidative phosphorylation_Homo sapiens_hsa001901.91453901
14Pentose phosphate pathway_Homo sapiens_hsa000301.87802340
15Parkinsons disease_Homo sapiens_hsa050121.85319166
16Carbon metabolism_Homo sapiens_hsa012001.82578993
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.74396848
18Pyrimidine metabolism_Homo sapiens_hsa002401.72834852
19Non-homologous end-joining_Homo sapiens_hsa034501.72221492
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69896963
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.67122455
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66815176
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62546837
24Spliceosome_Homo sapiens_hsa030401.61927913
25Fat digestion and absorption_Homo sapiens_hsa049751.61645548
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57079718
27One carbon pool by folate_Homo sapiens_hsa006701.56921745
28Basal transcription factors_Homo sapiens_hsa030221.56540383
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.56145087
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49925125
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49909694
32Base excision repair_Homo sapiens_hsa034101.48451258
33Biosynthesis of amino acids_Homo sapiens_hsa012301.47789173
34mRNA surveillance pathway_Homo sapiens_hsa030151.47244912
35Fructose and mannose metabolism_Homo sapiens_hsa000511.45305184
36Fatty acid biosynthesis_Homo sapiens_hsa000611.39556386
37Vitamin B6 metabolism_Homo sapiens_hsa007501.39154548
38Cell cycle_Homo sapiens_hsa041101.34109212
39Fatty acid degradation_Homo sapiens_hsa000711.31725743
40Nucleotide excision repair_Homo sapiens_hsa034201.29836471
41Cardiac muscle contraction_Homo sapiens_hsa042601.29540503
42Linoleic acid metabolism_Homo sapiens_hsa005911.29095989
43Alzheimers disease_Homo sapiens_hsa050101.28594710
44RNA polymerase_Homo sapiens_hsa030201.27501276
45Oocyte meiosis_Homo sapiens_hsa041141.26235795
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24284668
47Steroid biosynthesis_Homo sapiens_hsa001001.22939385
48Glutathione metabolism_Homo sapiens_hsa004801.20024073
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18225170
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15606132
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14903642
52Protein export_Homo sapiens_hsa030601.11860671
53Glucagon signaling pathway_Homo sapiens_hsa049221.09688073
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.05087842
55Sulfur metabolism_Homo sapiens_hsa009201.04889965
56RNA degradation_Homo sapiens_hsa030181.03353866
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03248390
58Nicotine addiction_Homo sapiens_hsa050331.02245451
59Systemic lupus erythematosus_Homo sapiens_hsa053221.00039414
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99205726
61Purine metabolism_Homo sapiens_hsa002300.98445228
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97229664
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96789796
64Chemical carcinogenesis_Homo sapiens_hsa052040.96424728
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90937975
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90383439
67Glycerolipid metabolism_Homo sapiens_hsa005610.89931517
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85675232
69PPAR signaling pathway_Homo sapiens_hsa033200.83862525
70Arginine biosynthesis_Homo sapiens_hsa002200.83822312
71Phototransduction_Homo sapiens_hsa047440.82438878
72Nitrogen metabolism_Homo sapiens_hsa009100.81873291
73Hippo signaling pathway_Homo sapiens_hsa043900.79448656
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78777268
75Fatty acid metabolism_Homo sapiens_hsa012120.77588555
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76477624
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75954803
78Butanoate metabolism_Homo sapiens_hsa006500.74574637
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73161735
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72233823
81Folate biosynthesis_Homo sapiens_hsa007900.71052856
82Tryptophan metabolism_Homo sapiens_hsa003800.67806428
83Metabolic pathways_Homo sapiens_hsa011000.67514839
84Proteasome_Homo sapiens_hsa030500.64125580
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63253039
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63128853
87Bile secretion_Homo sapiens_hsa049760.63000487
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62967481
89Wnt signaling pathway_Homo sapiens_hsa043100.62803889
90Hedgehog signaling pathway_Homo sapiens_hsa043400.62653192
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60635722
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59932463
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.57500595
94Fatty acid elongation_Homo sapiens_hsa000620.57198785
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54624915
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54340906
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54162727
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53156745
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.49671398
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48879300
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47797699
102Dorso-ventral axis formation_Homo sapiens_hsa043200.46719504
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.45840017
104Alcoholism_Homo sapiens_hsa050340.44392672
105Vitamin digestion and absorption_Homo sapiens_hsa049770.44390187
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43797604
107Lysine degradation_Homo sapiens_hsa003100.43291289
108Axon guidance_Homo sapiens_hsa043600.42747569
109Mineral absorption_Homo sapiens_hsa049780.41321940
110Arginine and proline metabolism_Homo sapiens_hsa003300.40155292
111AMPK signaling pathway_Homo sapiens_hsa041520.39752792
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39680036
113Retinol metabolism_Homo sapiens_hsa008300.36841142
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35921923
115p53 signaling pathway_Homo sapiens_hsa041150.35114306
116Galactose metabolism_Homo sapiens_hsa000520.34471534
117Bladder cancer_Homo sapiens_hsa052190.32724274
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32375621
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.31942355
120Peroxisome_Homo sapiens_hsa041460.31729504
121Basal cell carcinoma_Homo sapiens_hsa052170.30411779
122beta-Alanine metabolism_Homo sapiens_hsa004100.29302369
123Cocaine addiction_Homo sapiens_hsa050300.28400361
124Phenylalanine metabolism_Homo sapiens_hsa003600.25703102
125Olfactory transduction_Homo sapiens_hsa047400.25573093
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25500857
127Ether lipid metabolism_Homo sapiens_hsa005650.24227659

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