ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.56649198
2	seminiferous tubule development (GO:0072520)	4.53534981
3	regulation of mitochondrial translation (GO:0070129)	4.44758425
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.27054118
5	ATP synthesis coupled proton transport (GO:0015986)	4.04293380
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.04293380
7	establishment of integrated proviral latency (GO:0075713)	3.72161867
8	sequestering of actin monomers (GO:0042989)	3.59511279
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.59241311
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.39911077
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.39911077
12	DNA damage response, detection of DNA damage (GO:0042769)	3.36788210
13	protein localization to cilium (GO:0061512)	3.33786769
14	nucleobase catabolic process (GO:0046113)	3.28979704
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.26024928
16	chromatin remodeling at centromere (GO:0031055)	3.22077714
17	purine nucleobase biosynthetic process (GO:0009113)	3.20622112
18	protein complex biogenesis (GO:0070271)	3.16579209
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16247506
20	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.16065798
21	CENP-A containing nucleosome assembly (GO:0034080)	3.13647460
22	oxidative phosphorylation (GO:0006119)	3.10744756
23	cullin deneddylation (GO:0010388)	3.08916629
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.06442147
25	DNA double-strand break processing (GO:0000729)	3.05647994
26	L-serine metabolic process (GO:0006563)	3.02804057
27	negative regulation of telomere maintenance (GO:0032205)	3.01091115
28	NADH dehydrogenase complex assembly (GO:0010257)	2.99459484
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99459484
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99459484
31	presynaptic membrane assembly (GO:0097105)	2.99053040
32	neuron fate determination (GO:0048664)	2.95042775
33	neuron cell-cell adhesion (GO:0007158)	2.90333566
34	regulation of mitotic spindle checkpoint (GO:1903504)	2.90245890
35	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.90245890
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.87643491
37	epithelial cilium movement (GO:0003351)	2.87332316
38	proteasome assembly (GO:0043248)	2.87302911
39	single strand break repair (GO:0000012)	2.87217394
40	hyperosmotic salinity response (GO:0042538)	2.86722371
41	protein neddylation (GO:0045116)	2.85180641
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.83732707
43	histone H2A acetylation (GO:0043968)	2.80846243
44	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.80488720
45	establishment of viral latency (GO:0019043)	2.76307401
46	spliceosomal snRNP assembly (GO:0000387)	2.75853707
47	termination of RNA polymerase III transcription (GO:0006386)	2.75288740
48	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.75288740
49	transcription from mitochondrial promoter (GO:0006390)	2.73543872
50	protein deneddylation (GO:0000338)	2.73432289
51	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.72763670
52	aggressive behavior (GO:0002118)	2.72383727
53	purine deoxyribonucleotide catabolic process (GO:0009155)	2.67880223
54	respiratory electron transport chain (GO:0022904)	2.67764549
55	telomere maintenance via telomerase (GO:0007004)	2.66829939
56	intraciliary transport (GO:0042073)	2.66804755
57	RNA-dependent DNA replication (GO:0006278)	2.66078920
58	regulation of helicase activity (GO:0051095)	2.65345308
59	nucleobase biosynthetic process (GO:0046112)	2.65078871
60	electron transport chain (GO:0022900)	2.64786005
61	DNA replication-independent nucleosome organization (GO:0034724)	2.58701866
62	DNA replication-independent nucleosome assembly (GO:0006336)	2.58701866
63	respiratory chain complex IV assembly (GO:0008535)	2.57778714
64	behavioral response to nicotine (GO:0035095)	2.57434008
65	regulation of development, heterochronic (GO:0040034)	2.56664090
66	ribosomal small subunit assembly (GO:0000028)	2.55571602
67	histone exchange (GO:0043486)	2.55489118
68	chaperone-mediated protein transport (GO:0072321)	2.55341594
69	regulation of telomere maintenance (GO:0032204)	2.52147066
70	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52102156
71	protein polyglutamylation (GO:0018095)	2.50171783
72	iron-sulfur cluster assembly (GO:0016226)	2.48975831
73	metallo-sulfur cluster assembly (GO:0031163)	2.48975831
74	negative regulation of sister chromatid segregation (GO:0033046)	2.48867060
75	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.48867060
76	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.48867060
77	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.48867060
78	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.48867060
79	presynaptic membrane organization (GO:0097090)	2.48431159
80	vocalization behavior (GO:0071625)	2.46631680
81	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46099518
82	cytochrome complex assembly (GO:0017004)	2.44887682
83	neurofilament cytoskeleton organization (GO:0060052)	2.43587833
84	histone H3-K9 methylation (GO:0051567)	2.42310950
85	DNA strand elongation involved in DNA replication (GO:0006271)	2.42269803
86	regulation of penile erection (GO:0060405)	2.39790428
87	termination of RNA polymerase II transcription (GO:0006369)	2.39229452
88	retinal cone cell development (GO:0046549)	2.38124410
89	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.37916011
90	resolution of meiotic recombination intermediates (GO:0000712)	2.37616856
91	protein K11-linked ubiquitination (GO:0070979)	2.37508671
92	negative regulation of chromosome segregation (GO:0051985)	2.37505787
93	histone mRNA metabolic process (GO:0008334)	2.37133743
94	DNA ligation (GO:0006266)	2.36869480
95	protein localization to synapse (GO:0035418)	2.36602483
96	fatty acid elongation (GO:0030497)	2.35258026
97	telomere maintenance via semi-conservative replication (GO:0032201)	2.34108396
98	short-term memory (GO:0007614)	2.33135189
99	DNA-templated transcription, termination (GO:0006353)	2.32544919
100	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.32439047

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.85234513
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52180984
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.03222009
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94835647
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89394243
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84897566
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.77000294
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63577931
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.62037379
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.57324286
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44530032
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.40136221
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.36791424
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34097894
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.31126761
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.27398051
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.20179957
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.19266915
19	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.13389778
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12189851
21	VDR_22108803_ChIP-Seq_LS180_Human	2.05641737
22	FUS_26573619_Chip-Seq_HEK293_Human	2.01699753
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99161706
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.96656937
25	EWS_26573619_Chip-Seq_HEK293_Human	1.90485894
26	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.86085940
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.85049336
28	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.81989844
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.79998206
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74482903
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.72184087
32	P300_19829295_ChIP-Seq_ESCs_Human	1.71311386
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.68914506
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64595591
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.62585682
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61925722
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60389327
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59894434
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.56989389
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.55241305
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.52925003
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52791051
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50216627
44	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49143032
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49046053
46	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.48242098
47	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.47093095
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44572921
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44087352
50	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42087598
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.41892562
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37380472
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.36990030
54	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35444018
55	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.35363958
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34924061
57	XRN2_22483619_ChIP-Seq_HELA_Human	1.34753595
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33603132
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.33176862
60	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.32474673
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.30897558
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30207655
63	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.28945319
64	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28467776
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28053557
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.26886267
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25886730
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.25536667
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24116531
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.21587241
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.15200957
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14681795
73	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.12391857
74	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12345290
75	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.09265699
76	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07935162
77	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05850575
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05634329
79	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.04991921
80	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04364004
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.01444416
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01444416
83	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.00241634
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97231152
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.97096531
86	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.95058717
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94034720
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94003714
89	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.91638257
90	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.91638257
91	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.91638257
92	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91442050
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90850416
94	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.90828775
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.88378850
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.87646940
97	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.87564603
98	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.86049985
99	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86035654
100	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.85868626

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.13074025
2	MP0008877_abnormal_DNA_methylation	3.12006651
3	MP0003880_abnormal_central_pattern	2.82031171
4	MP0001529_abnormal_vocalization	2.72413389
5	MP0003122_maternal_imprinting	2.68699395
6	MP0006276_abnormal_autonomic_nervous	2.58658856
7	MP0008789_abnormal_olfactory_epithelium	2.24953246
8	MP0005499_abnormal_olfactory_system	2.22419970
9	MP0005394_taste/olfaction_phenotype	2.22419970
10	MP0002102_abnormal_ear_morphology	2.12179822
11	MP0003787_abnormal_imprinting	2.11305036
12	MP0002736_abnormal_nociception_after	2.09550481
13	MP0003121_genomic_imprinting	2.08610868
14	MP0004133_heterotaxia	2.00205902
15	MP0010094_abnormal_chromosome_stability	1.98768681
16	MP0003941_abnormal_skin_development	1.97965318
17	MP0001188_hyperpigmentation	1.92066910
18	MP0008058_abnormal_DNA_repair	1.91516320
19	MP0009046_muscle_twitch	1.83080345
20	MP0003136_yellow_coat_color	1.78563035
21	MP0000049_abnormal_middle_ear	1.77184916
22	MP0002234_abnormal_pharynx_morphology	1.76527326
23	MP0006035_abnormal_mitochondrial_morpho	1.76509826
24	MP0000566_synostosis	1.75618578
25	MP0009379_abnormal_foot_pigmentation	1.75219941
26	MP0001984_abnormal_olfaction	1.73440088
27	MP0006072_abnormal_retinal_apoptosis	1.72837823
28	MP0004859_abnormal_synaptic_plasticity	1.72631617
29	MP0000778_abnormal_nervous_system	1.70130541
30	MP0001968_abnormal_touch/_nociception	1.69567620
31	MP0003567_abnormal_fetal_cardiomyocyte	1.69336644
32	MP0005645_abnormal_hypothalamus_physiol	1.65102411
33	MP0005248_abnormal_Harderian_gland	1.47484065
34	MP0002272_abnormal_nervous_system	1.46040246
35	MP0002938_white_spotting	1.41111246
36	MP0002751_abnormal_autonomic_nervous	1.40728961
37	MP0008932_abnormal_embryonic_tissue	1.37886858
38	MP0002735_abnormal_chemical_nociception	1.37591135
39	MP0000631_abnormal_neuroendocrine_gland	1.36389286
40	MP0009697_abnormal_copulation	1.35714815
41	MP0010030_abnormal_orbit_morphology	1.34118678
42	MP0003635_abnormal_synaptic_transmissio	1.32914547
43	MP0004270_analgesia	1.28794025
44	MP0001293_anophthalmia	1.26909609
45	MP0005551_abnormal_eye_electrophysiolog	1.24920469
46	MP0003938_abnormal_ear_development	1.22544245
47	MP0003718_maternal_effect	1.22397885
48	MP0002572_abnormal_emotion/affect_behav	1.21948191
49	MP0004142_abnormal_muscle_tone	1.21915450
50	MP0003693_abnormal_embryo_hatching	1.20662923
51	MP0002734_abnormal_mechanical_nocicepti	1.19478797
52	MP0009745_abnormal_behavioral_response	1.18820141
53	MP0005253_abnormal_eye_physiology	1.17122051
54	MP0001486_abnormal_startle_reflex	1.15051546
55	MP0002638_abnormal_pupillary_reflex	1.15001132
56	MP0002557_abnormal_social/conspecific_i	1.14857457
57	MP0003221_abnormal_cardiomyocyte_apopto	1.14118223
58	MP0003077_abnormal_cell_cycle	1.13740831
59	MP0002063_abnormal_learning/memory/cond	1.13732719
60	MP0005084_abnormal_gallbladder_morpholo	1.10875961
61	MP0004957_abnormal_blastocyst_morpholog	1.09955053
62	MP0003937_abnormal_limbs/digits/tail_de	1.09809971
63	MP0003119_abnormal_digestive_system	1.07866497
64	MP0001177_atelectasis	1.07361290
65	MP0008007_abnormal_cellular_replicative	1.04139376
66	MP0004742_abnormal_vestibular_system	1.03696921
67	MP0010386_abnormal_urinary_bladder	1.03257164
68	MP0002067_abnormal_sensory_capabilities	1.02843907
69	MP0005423_abnormal_somatic_nervous	1.02715246
70	MP0003111_abnormal_nucleus_morphology	1.00989765
71	MP0003890_abnormal_embryonic-extraembry	1.00927113
72	MP0001485_abnormal_pinna_reflex	0.99483493
73	MP0000026_abnormal_inner_ear	0.98897771
74	MP0002822_catalepsy	0.98856796
75	MP0001905_abnormal_dopamine_level	0.97344353
76	MP0002752_abnormal_somatic_nervous	0.97227106
77	MP0002090_abnormal_vision	0.96788805
78	MP0002882_abnormal_neuron_morphology	0.90461054
79	MP0003137_abnormal_impulse_conducting	0.90012071
80	MP0002184_abnormal_innervation	0.89972181
81	MP0005367_renal/urinary_system_phenotyp	0.89001317
82	MP0000516_abnormal_urinary_system	0.89001317
83	MP0003011_delayed_dark_adaptation	0.88048630
84	MP0000358_abnormal_cell_content/	0.87312413
85	MP0001286_abnormal_eye_development	0.86072500
86	MP0002697_abnormal_eye_size	0.85867090
87	MP0003861_abnormal_nervous_system	0.84902813
88	MP0000955_abnormal_spinal_cord	0.84430902
89	MP0006036_abnormal_mitochondrial_physio	0.83707076
90	MP0002733_abnormal_thermal_nociception	0.82432513
91	MP0008995_early_reproductive_senescence	0.81985711
92	MP0005195_abnormal_posterior_eye	0.81513593
93	MP0001970_abnormal_pain_threshold	0.81100376
94	MP0000569_abnormal_digit_pigmentation	0.80973697
95	MP0001963_abnormal_hearing_physiology	0.80730598
96	MP0002233_abnormal_nose_morphology	0.80306204
97	MP0002152_abnormal_brain_morphology	0.78625875
98	MP0002064_seizures	0.78477883
99	MP0002282_abnormal_trachea_morphology	0.78306069
100	MP0004811_abnormal_neuron_physiology	0.76544610

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	3.69380324
2	Increased hepatocellular lipid droplets (HP:0006565)	3.68994679
3	Abnormality of the labia minora (HP:0012880)	3.45458520
4	Lipid accumulation in hepatocytes (HP:0006561)	3.37155944
5	Cortical dysplasia (HP:0002539)	3.33228798
6	Pancreatic fibrosis (HP:0100732)	3.27480698
7	Colon cancer (HP:0003003)	3.20312063
8	Myokymia (HP:0002411)	3.18273118
9	Acute necrotizing encephalopathy (HP:0006965)	3.16231801
10	Abnormal mitochondria in muscle tissue (HP:0008316)	2.93513593
11	Mitochondrial inheritance (HP:0001427)	2.92125529
12	Acute encephalopathy (HP:0006846)	2.90305588
13	True hermaphroditism (HP:0010459)	2.87597043
14	Hyperglycinemia (HP:0002154)	2.86159600
15	Increased intramyocellular lipid droplets (HP:0012240)	2.77689750
16	Pancreatic cysts (HP:0001737)	2.72133064
17	Atonic seizures (HP:0010819)	2.70848648
18	Polyphagia (HP:0002591)	2.62809667
19	Focal motor seizures (HP:0011153)	2.62406151
20	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.60864769
21	Optic nerve hypoplasia (HP:0000609)	2.58600052
22	Progressive macrocephaly (HP:0004481)	2.52713354
23	Limb dystonia (HP:0002451)	2.52094051
24	Hyperglycinuria (HP:0003108)	2.44501267
25	Short tibia (HP:0005736)	2.42671056
26	Nephronophthisis (HP:0000090)	2.42089695
27	Supernumerary spleens (HP:0009799)	2.41926036
28	Increased CSF lactate (HP:0002490)	2.39898144
29	Bile duct proliferation (HP:0001408)	2.38228848
30	Abnormal biliary tract physiology (HP:0012439)	2.38228848
31	Increased muscle lipid content (HP:0009058)	2.37626265
32	Hepatocellular necrosis (HP:0001404)	2.36682383
33	Abnormality of serine family amino acid metabolism (HP:0010894)	2.33803318
34	Abnormality of glycine metabolism (HP:0010895)	2.33803318
35	Renal Fanconi syndrome (HP:0001994)	2.33724542
36	Febrile seizures (HP:0002373)	2.30544818
37	Absent septum pellucidum (HP:0001331)	2.22103011
38	Esophageal atresia (HP:0002032)	2.19293346
39	Rib fusion (HP:0000902)	2.18996115
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.18162889
41	Hypothermia (HP:0002045)	2.17936873
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.17383680
43	Methylmalonic acidemia (HP:0002912)	2.16997387
44	Abnormality of midbrain morphology (HP:0002418)	2.15883746
45	Molar tooth sign on MRI (HP:0002419)	2.15883746
46	Lissencephaly (HP:0001339)	2.12853728
47	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.09466595
48	Dialeptic seizures (HP:0011146)	2.06640440
49	Focal seizures (HP:0007359)	2.06428002
50	Gait imbalance (HP:0002141)	2.05579472
51	Failure to thrive in infancy (HP:0001531)	2.04041742
52	Anencephaly (HP:0002323)	2.01965173
53	Medial flaring of the eyebrow (HP:0010747)	2.01899782
54	Genital tract atresia (HP:0001827)	1.99784462
55	Postnatal microcephaly (HP:0005484)	1.99339302
56	Hypoglycemic seizures (HP:0002173)	1.97897832
57	Congenital primary aphakia (HP:0007707)	1.95554482
58	Exertional dyspnea (HP:0002875)	1.95410009
59	Methylmalonic aciduria (HP:0012120)	1.95228928
60	Abnormal respiratory epithelium morphology (HP:0012253)	1.93944273
61	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93944273
62	Abnormality of the anterior horn cell (HP:0006802)	1.93421371
63	Degeneration of anterior horn cells (HP:0002398)	1.93421371
64	Retinal dysplasia (HP:0007973)	1.93313497
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.92816166
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.92816166
67	Cerebral edema (HP:0002181)	1.92796501
68	Abnormality of the septum pellucidum (HP:0007375)	1.92772506
69	Amyotrophic lateral sclerosis (HP:0007354)	1.91250774
70	Gastrointestinal atresia (HP:0002589)	1.90940306
71	Meckel diverticulum (HP:0002245)	1.89805940
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89216068
73	Hepatic necrosis (HP:0002605)	1.89188516
74	Poor suck (HP:0002033)	1.89154137
75	Sclerocornea (HP:0000647)	1.88434911
76	Delayed CNS myelination (HP:0002188)	1.87960978
77	Drooling (HP:0002307)	1.87907359
78	Maternal diabetes (HP:0009800)	1.87672790
79	Split foot (HP:0001839)	1.85700095
80	Triphalangeal thumb (HP:0001199)	1.85300233
81	Oligodactyly (hands) (HP:0001180)	1.84446459
82	Thyroid-stimulating hormone excess (HP:0002925)	1.84440387
83	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.81453075
84	Carpal bone hypoplasia (HP:0001498)	1.80540529
85	Pendular nystagmus (HP:0012043)	1.79699118
86	Hyperinsulinemic hypoglycemia (HP:0000825)	1.79569426
87	Postaxial foot polydactyly (HP:0001830)	1.78381742
88	Vaginal atresia (HP:0000148)	1.77997457
89	Abnormality of the parathyroid morphology (HP:0011766)	1.77382782
90	Progressive inability to walk (HP:0002505)	1.76934203
91	Growth hormone deficiency (HP:0000824)	1.76017334
92	Progressive microcephaly (HP:0000253)	1.75352006
93	Bifid tongue (HP:0010297)	1.75348094
94	Occipital encephalocele (HP:0002085)	1.75164356
95	Abnormality of the ileum (HP:0001549)	1.73796000
96	Abnormality of serum amino acid levels (HP:0003112)	1.72498423
97	Hemivertebrae (HP:0002937)	1.72081326
98	Optic disc pallor (HP:0000543)	1.71806327
99	Nephrogenic diabetes insipidus (HP:0009806)	1.71759965
100	Reticulocytopenia (HP:0001896)	1.71220921

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.68991440
2	CDK19	3.91062163
3	TRIM28	2.71548616
4	BCR	2.64684208
5	SRPK1	2.64633749
6	BCKDK	2.54287072
7	WNK3	2.29231101
8	DYRK2	2.13291847
9	BUB1	2.04434095
10	CASK	1.97396791
11	TNIK	1.96414887
12	VRK2	1.90675692
13	PIM2	1.89098022
14	MAP2K7	1.82493591
15	PLK4	1.79218139
16	DYRK3	1.76551108
17	CSNK1G2	1.75498545
18	MARK1	1.72592547
19	CSNK1G3	1.71590891
20	MAPK13	1.71220798
21	BMPR1B	1.70373962
22	CDC7	1.69676034
23	NME1	1.69501752
24	EPHA4	1.68990392
25	TSSK6	1.64018997
26	MAP3K4	1.61487601
27	NUAK1	1.61139870
28	NEK1	1.59534760
29	CSNK1A1L	1.53101925
30	MKNK1	1.44133290
31	FLT3	1.41469657
32	CSNK1G1	1.40107621
33	PLK2	1.39730518
34	VRK1	1.38586532
35	STK16	1.35226453
36	MAP3K5	1.30715024
37	DYRK1B	1.30138010
38	PLK3	1.27177034
39	UHMK1	1.27008972
40	TTK	1.25232917
41	MAP3K12	1.23917426
42	NTRK2	1.22097174
43	ZAK	1.14476740
44	MKNK2	1.07018664
45	EIF2AK3	1.05646594
46	PLK1	0.99064611
47	MINK1	0.91445835
48	KIT	0.85548930
49	RPS6KA4	0.85370057
50	CDK14	0.80804162
51	PBK	0.75130459
52	ATR	0.74283775
53	MAP2K4	0.73524474
54	SCYL2	0.73504112
55	TESK1	0.71906764
56	CDK11A	0.71083791
57	PRKCG	0.69414478
58	LIMK1	0.69123414
59	CSNK1A1	0.64801749
60	TESK2	0.64530738
61	RPS6KA5	0.63219746
62	CAMK2A	0.62944430
63	CDK18	0.61145241
64	ADRBK2	0.60882780
65	WEE1	0.60273763
66	CCNB1	0.59970004
67	GRK1	0.57890455
68	PRKD3	0.57243227
69	CDK15	0.55180580
70	CSNK2A1	0.51203868
71	DYRK1A	0.50224924
72	OXSR1	0.48538078
73	TGFBR1	0.48005374
74	CHEK2	0.47736096
75	TIE1	0.47468188
76	PASK	0.47120600
77	KDR	0.46723408
78	PAK6	0.46209649
79	AURKB	0.46000726
80	PINK1	0.45947329
81	BRSK1	0.44286991
82	CAMK2B	0.43614643
83	ERBB3	0.43283906
84	INSRR	0.43121544
85	PRKCE	0.43057866
86	PAK3	0.41927734
87	CSNK1E	0.41699936
88	CSNK2A2	0.41659846
89	CSNK1D	0.40505793
90	ATM	0.38861602
91	CLK1	0.35860084
92	ALK	0.35779121
93	CDK5	0.35106810
94	ADRBK1	0.31987495
95	PRKACB	0.31755616
96	PIK3CA	0.31028235
97	DAPK1	0.30681820
98	PRKDC	0.30044577
99	CDK2	0.29728825
100	EIF2AK1	0.29083545

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.10386297
2	Parkinsons disease_Homo sapiens_hsa05012	2.95940095
3	Nicotine addiction_Homo sapiens_hsa05033	2.80363930
4	RNA polymerase_Homo sapiens_hsa03020	2.62765166
5	Mismatch repair_Homo sapiens_hsa03430	2.54274384
6	Proteasome_Homo sapiens_hsa03050	2.45713178
7	DNA replication_Homo sapiens_hsa03030	2.42820354
8	Protein export_Homo sapiens_hsa03060	2.34796080
9	Huntingtons disease_Homo sapiens_hsa05016	2.17853585
10	Homologous recombination_Homo sapiens_hsa03440	2.17501194
11	Ribosome_Homo sapiens_hsa03010	1.98387846
12	Base excision repair_Homo sapiens_hsa03410	1.97129749
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95801063
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.91965894
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.84236309
16	Spliceosome_Homo sapiens_hsa03040	1.82212787
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81583994
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.79536026
19	Phototransduction_Homo sapiens_hsa04744	1.72036095
20	Alzheimers disease_Homo sapiens_hsa05010	1.71906821
21	Propanoate metabolism_Homo sapiens_hsa00640	1.71653662
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65186830
23	Folate biosynthesis_Homo sapiens_hsa00790	1.57950495
24	GABAergic synapse_Homo sapiens_hsa04727	1.56957359
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.54035754
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52484304
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50446047
28	Basal transcription factors_Homo sapiens_hsa03022	1.47970773
29	Fatty acid elongation_Homo sapiens_hsa00062	1.47952117
30	RNA degradation_Homo sapiens_hsa03018	1.47556391
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43560695
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.42877816
33	RNA transport_Homo sapiens_hsa03013	1.42148272
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37928490
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34922359
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.32548496
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25838920
38	One carbon pool by folate_Homo sapiens_hsa00670	1.23117840
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.21417540
40	Taste transduction_Homo sapiens_hsa04742	1.16425317
41	Nucleotide excision repair_Homo sapiens_hsa03420	1.15466525
42	Purine metabolism_Homo sapiens_hsa00230	1.15158774
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10589208
44	Morphine addiction_Homo sapiens_hsa05032	1.08843916
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06792694
46	Cell cycle_Homo sapiens_hsa04110	1.05762980
47	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.03616812
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02012908
49	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.99247249
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98356558
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97707830
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.96925733
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96262651
54	Oocyte meiosis_Homo sapiens_hsa04114	0.95665280
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.94855797
56	Carbon metabolism_Homo sapiens_hsa01200	0.89289071
57	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.85953735
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.83718320
59	Peroxisome_Homo sapiens_hsa04146	0.80633884
60	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.80290322
61	mRNA surveillance pathway_Homo sapiens_hsa03015	0.80219888
62	Butanoate metabolism_Homo sapiens_hsa00650	0.77634087
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76932419
64	Metabolic pathways_Homo sapiens_hsa01100	0.72259538
65	Serotonergic synapse_Homo sapiens_hsa04726	0.71415989
66	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.70820182
67	p53 signaling pathway_Homo sapiens_hsa04115	0.70130781
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67815332
69	Circadian entrainment_Homo sapiens_hsa04713	0.66903556
70	Cocaine addiction_Homo sapiens_hsa05030	0.63880936
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.63199291
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61580993
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.58405078
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56320561
75	Long-term depression_Homo sapiens_hsa04730	0.54556691
76	Caffeine metabolism_Homo sapiens_hsa00232	0.54138949
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52162814
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.51280685
79	Glutathione metabolism_Homo sapiens_hsa00480	0.50726897
80	Alcoholism_Homo sapiens_hsa05034	0.48860548
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47565795
82	Olfactory transduction_Homo sapiens_hsa04740	0.47425226
83	Regulation of autophagy_Homo sapiens_hsa04140	0.45128441
84	Amphetamine addiction_Homo sapiens_hsa05031	0.43903825
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.43878162
86	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.43615189
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42720651
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40675369
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.40519041
90	Nitrogen metabolism_Homo sapiens_hsa00910	0.40012103
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37785216
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37717933
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35222643
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34976369
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.34175443
96	Sulfur relay system_Homo sapiens_hsa04122	0.34009035
97	Retinol metabolism_Homo sapiens_hsa00830	0.33983197
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.29463284
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29012190
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28170212

CENPVP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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