ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hyperosmotic salinity response (GO:0042538)	6.21951619
2	histone H2A acetylation (GO:0043968)	5.24908308
3	sequestering of actin monomers (GO:0042989)	4.61351086
4	proteasome assembly (GO:0043248)	4.42289679
5	pyrimidine nucleobase catabolic process (GO:0006208)	4.39589449
6	L-fucose catabolic process (GO:0042355)	4.25956676
7	fucose catabolic process (GO:0019317)	4.25956676
8	L-fucose metabolic process (GO:0042354)	4.25956676
9	DNA double-strand break processing (GO:0000729)	4.10342273
10	aminoglycoside antibiotic metabolic process (GO:0030647)	4.03310562
11	DNA damage response, detection of DNA damage (GO:0042769)	3.88011934
12	intraciliary transport (GO:0042073)	3.82745062
13	regulation of penile erection (GO:0060405)	3.77585058
14	positive regulation of action potential (GO:0045760)	3.72537968
15	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.70236659
16	maternal behavior (GO:0042711)	3.59264104
17	aggressive behavior (GO:0002118)	3.56595904
18	protein localization to cilium (GO:0061512)	3.55395771
19	positive regulation of prostaglandin secretion (GO:0032308)	3.50560910
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.48867302
21	nucleobase catabolic process (GO:0046113)	3.46963663
22	auditory behavior (GO:0031223)	3.43330704
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.40661039
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.40661039
25	opioid receptor signaling pathway (GO:0038003)	3.32116013
26	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.24862915
27	epithelial cilium movement (GO:0003351)	3.17549901
28	L-methionine biosynthetic process (GO:0071265)	3.14829368
29	amino acid salvage (GO:0043102)	3.14829368
30	L-methionine salvage (GO:0071267)	3.14829368
31	regulation of hippo signaling (GO:0035330)	3.13815541
32	regulation of prostaglandin secretion (GO:0032306)	3.11667166
33	meiotic chromosome segregation (GO:0045132)	3.11544461
34	cullin deneddylation (GO:0010388)	3.09818766
35	seminiferous tubule development (GO:0072520)	3.05671596
36	parental behavior (GO:0060746)	3.05630341
37	negative regulation of telomere maintenance (GO:0032205)	3.03389331
38	regulation of development, heterochronic (GO:0040034)	3.03105532
39	positive regulation of mitochondrial fission (GO:0090141)	3.01733581
40	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.01017847
41	CTP metabolic process (GO:0046036)	2.99302579
42	CTP biosynthetic process (GO:0006241)	2.99302579
43	establishment of integrated proviral latency (GO:0075713)	2.95609770
44	GTP biosynthetic process (GO:0006183)	2.94248515
45	spliceosomal snRNP assembly (GO:0000387)	2.93994244
46	synapsis (GO:0007129)	2.93372429
47	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.89110612
48	somite development (GO:0061053)	2.85935712
49	microtubule depolymerization (GO:0007019)	2.84992261
50	negative regulation of B cell apoptotic process (GO:0002903)	2.82882159
51	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.82087796
52	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.81710181
53	positive regulation of amino acid transport (GO:0051957)	2.78967871
54	regulation of telomere maintenance via telomerase (GO:0032210)	2.77341020
55	chromatin remodeling at centromere (GO:0031055)	2.76643337
56	protein deneddylation (GO:0000338)	2.76134299
57	phosphate ion transport (GO:0006817)	2.75325483
58	cilium or flagellum-dependent cell motility (GO:0001539)	2.75223418
59	mitochondrial calcium ion transport (GO:0006851)	2.72420196
60	branched-chain amino acid catabolic process (GO:0009083)	2.72206168
61	CENP-A containing nucleosome assembly (GO:0034080)	2.71577687
62	UTP metabolic process (GO:0046051)	2.71095126
63	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.69997166
64	protein neddylation (GO:0045116)	2.69854067
65	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.66908764
66	negative regulation of JAK-STAT cascade (GO:0046426)	2.66490600
67	mechanosensory behavior (GO:0007638)	2.63115963
68	neuron fate determination (GO:0048664)	2.63018666
69	methionine biosynthetic process (GO:0009086)	2.62876587
70	negative regulation of Notch signaling pathway (GO:0045746)	2.61334092
71	olfactory bulb development (GO:0021772)	2.59186625
72	transcription from mitochondrial promoter (GO:0006390)	2.56645395
73	neuronal action potential (GO:0019228)	2.55890759
74	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.55627737
75	methionine metabolic process (GO:0006555)	2.53369102
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.52891408
77	NADH dehydrogenase complex assembly (GO:0010257)	2.52891408
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.52891408
79	pyrimidine dimer repair (GO:0006290)	2.52852402
80	regulation of female receptivity (GO:0045924)	2.52536492
81	layer formation in cerebral cortex (GO:0021819)	2.51853790
82	grooming behavior (GO:0007625)	2.51125233
83	iron-sulfur cluster assembly (GO:0016226)	2.51031235
84	metallo-sulfur cluster assembly (GO:0031163)	2.51031235
85	UTP biosynthetic process (GO:0006228)	2.49784315
86	microtubule polymerization or depolymerization (GO:0031109)	2.49661509
87	termination of RNA polymerase II transcription (GO:0006369)	2.48133733
88	cholesterol biosynthetic process (GO:0006695)	2.47405867
89	mRNA splice site selection (GO:0006376)	2.46795552
90	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.44362916
91	ribonucleoprotein complex disassembly (GO:0032988)	2.43739384
92	purine nucleobase biosynthetic process (GO:0009113)	2.43202845
93	detection of calcium ion (GO:0005513)	2.41924108
94	protein K11-linked ubiquitination (GO:0070979)	2.41224127
95	regulation of mitochondrial translation (GO:0070129)	2.41160631
96	DNA ligation (GO:0006266)	2.39568149
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.39366484
98	sulfur amino acid biosynthetic process (GO:0000097)	2.38688800
99	doxorubicin metabolic process (GO:0044598)	2.38118672
100	daunorubicin metabolic process (GO:0044597)	2.38118672

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.42594934
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.67089548
3	GATA1_22025678_ChIP-Seq_K562_Human	4.15179211
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.30964253
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93907616
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67131065
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61394372
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.54890573
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.20319373
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20013065
11	FUS_26573619_Chip-Seq_HEK293_Human	2.11874857
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11669587
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.07659403
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.06813988
15	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.06523108
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.00300669
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.98520600
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97718749
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.94533829
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93418462
21	VDR_22108803_ChIP-Seq_LS180_Human	1.92827088
22	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.79880248
23	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.78804448
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.76203866
25	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.71307243
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70722598
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.69508466
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69210649
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66852300
30	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.66177610
31	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.63733728
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.63207927
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62078795
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.58711224
35	EWS_26573619_Chip-Seq_HEK293_Human	1.56991347
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56363911
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.51411827
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49811686
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.49518951
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49205124
41	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.48403195
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.45017806
43	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43525512
44	P300_19829295_ChIP-Seq_ESCs_Human	1.43089644
45	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.42370397
46	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42328996
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40242430
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37654072
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35907810
50	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.33651513
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31943768
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29677278
53	GBX2_23144817_ChIP-Seq_PC3_Human	1.28807958
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.26407199
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24761089
56	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.24718668
57	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23706379
58	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.22304729
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.18053638
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17128180
61	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.16396116
62	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.15771997
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.14021964
64	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.13537551
65	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.12968169
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.12372657
67	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.11919432
68	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.11659327
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11181194
70	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10484996
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10152534
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.09520757
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08818457
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08782851
75	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.07176925
76	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.04238336
77	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01260422
78	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.98835169
79	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.98022273
80	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97216975
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96311223
82	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94863645
83	AR_25329375_ChIP-Seq_VCAP_Human	0.94608890
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92013610
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89896297
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.89442425
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.89220282
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89220282
89	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.88747293
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88515522
91	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.88279920
92	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88053204
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.87151438
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.85837005
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.84942689
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84492642
97	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.84292031
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.84041170
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.84031062
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.82410989

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.41280408
2	MP0001529_abnormal_vocalization	3.06664561
3	MP0003136_yellow_coat_color	2.87853308
4	MP0008789_abnormal_olfactory_epithelium	2.74028981
5	MP0003880_abnormal_central_pattern	2.73583407
6	MP0006072_abnormal_retinal_apoptosis	2.72605153
7	MP0005645_abnormal_hypothalamus_physiol	2.59668684
8	MP0002234_abnormal_pharynx_morphology	2.58209036
9	MP0005394_taste/olfaction_phenotype	2.54903762
10	MP0005499_abnormal_olfactory_system	2.54903762
11	MP0003122_maternal_imprinting	2.40822100
12	MP0004147_increased_porphyrin_level	2.40456482
13	MP0004133_heterotaxia	2.38956305
14	MP0006276_abnormal_autonomic_nervous	2.38946864
15	MP0000049_abnormal_middle_ear	1.99895859
16	MP0000778_abnormal_nervous_system	1.87652066
17	MP0005253_abnormal_eye_physiology	1.77280853
18	MP0005248_abnormal_Harderian_gland	1.72061997
19	MP0002736_abnormal_nociception_after	1.71812072
20	MP0002735_abnormal_chemical_nociception	1.70117153
21	MP0003567_abnormal_fetal_cardiomyocyte	1.64534693
22	MP0002751_abnormal_autonomic_nervous	1.60446160
23	MP0008058_abnormal_DNA_repair	1.57274671
24	MP0005377_hearing/vestibular/ear_phenot	1.53130821
25	MP0003878_abnormal_ear_physiology	1.53130821
26	MP0010030_abnormal_orbit_morphology	1.52376326
27	MP0008932_abnormal_embryonic_tissue	1.52253444
28	MP0000566_synostosis	1.47773468
29	MP0000631_abnormal_neuroendocrine_gland	1.47017116
30	MP0002557_abnormal_social/conspecific_i	1.46085989
31	MP0008877_abnormal_DNA_methylation	1.43167767
32	MP0001486_abnormal_startle_reflex	1.40729068
33	MP0001984_abnormal_olfaction	1.37111763
34	MP0010094_abnormal_chromosome_stability	1.37035499
35	MP0002653_abnormal_ependyma_morphology	1.34581813
36	MP0000516_abnormal_urinary_system	1.28713407
37	MP0005367_renal/urinary_system_phenotyp	1.28713407
38	MP0002282_abnormal_trachea_morphology	1.28133540
39	MP0003121_genomic_imprinting	1.27389372
40	MP0001177_atelectasis	1.23349055
41	MP0003938_abnormal_ear_development	1.22018454
42	MP0001764_abnormal_homeostasis	1.20421772
43	MP0002102_abnormal_ear_morphology	1.17941376
44	MP0003119_abnormal_digestive_system	1.17453561
45	MP0010386_abnormal_urinary_bladder	1.16311627
46	MP0003693_abnormal_embryo_hatching	1.15966259
47	MP0004859_abnormal_synaptic_plasticity	1.15120177
48	MP0005551_abnormal_eye_electrophysiolog	1.11452511
49	MP0003137_abnormal_impulse_conducting	1.11228724
50	MP0002184_abnormal_innervation	1.10455079
51	MP0009745_abnormal_behavioral_response	1.10165208
52	MP0000537_abnormal_urethra_morphology	1.07890345
53	MP0003635_abnormal_synaptic_transmissio	1.05547311
54	MP0005195_abnormal_posterior_eye	1.02344133
55	MP0009672_abnormal_birth_weight	1.01626880
56	MP0000538_abnormal_urinary_bladder	1.01483165
57	MP0002752_abnormal_somatic_nervous	1.00814692
58	MP0004782_abnormal_surfactant_physiolog	1.00003329
59	MP0002160_abnormal_reproductive_system	0.99778644
60	MP0006035_abnormal_mitochondrial_morpho	0.99520739
61	MP0002938_white_spotting	0.99509249
62	MP0003283_abnormal_digestive_organ	0.98196555
63	MP0002063_abnormal_learning/memory/cond	0.98058011
64	MP0001963_abnormal_hearing_physiology	0.97975880
65	MP0002572_abnormal_emotion/affect_behav	0.97954704
66	MP0009046_muscle_twitch	0.97926312
67	MP0005391_vision/eye_phenotype	0.97252693
68	MP0001293_anophthalmia	0.97188287
69	MP0002067_abnormal_sensory_capabilities	0.97105705
70	MP0001545_abnormal_hematopoietic_system	0.96759142
71	MP0005397_hematopoietic_system_phenotyp	0.96759142
72	MP0000372_irregular_coat_pigmentation	0.96215667
73	MP0008995_early_reproductive_senescence	0.95862585
74	MP0000026_abnormal_inner_ear	0.95687867
75	MP0002272_abnormal_nervous_system	0.93726980
76	MP0001968_abnormal_touch/_nociception	0.93491098
77	MP0000955_abnormal_spinal_cord	0.92092534
78	MP0003787_abnormal_imprinting	0.91450017
79	MP0001485_abnormal_pinna_reflex	0.90926483
80	MP0002233_abnormal_nose_morphology	0.90836468
81	MP0006036_abnormal_mitochondrial_physio	0.90112595
82	MP0009697_abnormal_copulation	0.89449069
83	MP0004142_abnormal_muscle_tone	0.89130810
84	MP0005085_abnormal_gallbladder_physiolo	0.88980837
85	MP0002822_catalepsy	0.88928781
86	MP0002928_abnormal_bile_duct	0.88176925
87	MP0003718_maternal_effect	0.86660771
88	MP0001986_abnormal_taste_sensitivity	0.86194896
89	MP0002882_abnormal_neuron_morphology	0.85206123
90	MP0003937_abnormal_limbs/digits/tail_de	0.84070006
91	MP0002069_abnormal_eating/drinking_beha	0.83785451
92	MP0006054_spinal_hemorrhage	0.83061981
93	MP0005257_abnormal_intraocular_pressure	0.80816127
94	MP0003077_abnormal_cell_cycle	0.80216515
95	MP0003861_abnormal_nervous_system	0.79895927
96	MP0002734_abnormal_mechanical_nocicepti	0.79650516
97	MP0000678_abnormal_parathyroid_gland	0.79329328
98	MP0001905_abnormal_dopamine_level	0.79140080
99	MP0000751_myopathy	0.79070352
100	MP0001970_abnormal_pain_threshold	0.77666093

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	4.15161266
2	True hermaphroditism (HP:0010459)	4.08966309
3	Nephronophthisis (HP:0000090)	3.54023194
4	Septo-optic dysplasia (HP:0100842)	3.47018239
5	Pancreatic fibrosis (HP:0100732)	3.42085950
6	Elevated erythrocyte sedimentation rate (HP:0003565)	3.27961954
7	Generalized aminoaciduria (HP:0002909)	3.05481226
8	Pancreatic cysts (HP:0001737)	2.94470666
9	Abnormal biliary tract physiology (HP:0012439)	2.94443024
10	Bile duct proliferation (HP:0001408)	2.94443024
11	3-Methylglutaconic aciduria (HP:0003535)	2.85947120
12	Myokymia (HP:0002411)	2.84680163
13	Abnormality of macular pigmentation (HP:0008002)	2.84438458
14	Proximal tubulopathy (HP:0000114)	2.83445618
15	Anencephaly (HP:0002323)	2.80106121
16	Abnormality of the labia minora (HP:0012880)	2.72564242
17	Morphological abnormality of the middle ear (HP:0008609)	2.64444927
18	Postaxial foot polydactyly (HP:0001830)	2.60884027
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.57251378
20	Optic nerve hypoplasia (HP:0000609)	2.55379178
21	Oligodactyly (hands) (HP:0001180)	2.54022677
22	Dyskinesia (HP:0100660)	2.53083911
23	Microvesicular hepatic steatosis (HP:0001414)	2.50156473
24	Hyperglycinuria (HP:0003108)	2.49938136
25	Chronic hepatic failure (HP:0100626)	2.49085339
26	Occipital encephalocele (HP:0002085)	2.47553040
27	Abnormality of serine family amino acid metabolism (HP:0010894)	2.46940591
28	Abnormality of glycine metabolism (HP:0010895)	2.46940591
29	Abolished electroretinogram (ERG) (HP:0000550)	2.46606278
30	Abnormality of the renal medulla (HP:0100957)	2.33027159
31	Intestinal atresia (HP:0011100)	2.32962816
32	Abnormality of the anterior horn cell (HP:0006802)	2.32694589
33	Degeneration of anterior horn cells (HP:0002398)	2.32694589
34	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.32094103
35	Colon cancer (HP:0003003)	2.24786418
36	Congenital primary aphakia (HP:0007707)	2.22745524
37	Preaxial hand polydactyly (HP:0001177)	2.22189460
38	Supernumerary spleens (HP:0009799)	2.21519006
39	Gait imbalance (HP:0002141)	2.20694609
40	Abnormality of the antihelix (HP:0009738)	2.19813554
41	Esophageal atresia (HP:0002032)	2.19550156
42	Increased hepatocellular lipid droplets (HP:0006565)	2.19021499
43	Sclerocornea (HP:0000647)	2.17444577
44	Severe Myopia (HP:0011003)	2.14876108
45	Cortical dysplasia (HP:0002539)	2.13859885
46	Anophthalmia (HP:0000528)	2.12147063
47	Poor eye contact (HP:0000817)	2.12063804
48	Rib fusion (HP:0000902)	2.11612729
49	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.11355459
50	Molar tooth sign on MRI (HP:0002419)	2.09154283
51	Abnormality of midbrain morphology (HP:0002418)	2.09154283
52	Medial flaring of the eyebrow (HP:0010747)	2.08494644
53	Lipid accumulation in hepatocytes (HP:0006561)	2.07854184
54	Genital tract atresia (HP:0001827)	2.07638329
55	Cystic liver disease (HP:0006706)	2.07323810
56	Atonic seizures (HP:0010819)	2.07008445
57	Congenital stationary night blindness (HP:0007642)	2.05155971
58	Renal cortical cysts (HP:0000803)	2.04551228
59	Hyperphosphaturia (HP:0003109)	2.04313000
60	Short tibia (HP:0005736)	2.03840479
61	Vaginal atresia (HP:0000148)	1.99882601
62	Microretrognathia (HP:0000308)	1.98888965
63	Nephrogenic diabetes insipidus (HP:0009806)	1.98500990
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98010587
65	Gonadotropin excess (HP:0000837)	1.97376751
66	Postaxial hand polydactyly (HP:0001162)	1.92504054
67	Stenosis of the external auditory canal (HP:0000402)	1.92236817
68	Glycosuria (HP:0003076)	1.91995240
69	Abnormality of urine glucose concentration (HP:0011016)	1.91995240
70	Athetosis (HP:0002305)	1.91778117
71	Hyperglycinemia (HP:0002154)	1.90271656
72	Oligodactyly (HP:0012165)	1.90233607
73	Type I transferrin isoform profile (HP:0003642)	1.89901624
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84717792
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.84717792
76	Congenital hepatic fibrosis (HP:0002612)	1.82532897
77	Abnormality of the parathyroid morphology (HP:0011766)	1.81989581
78	Chorioretinal coloboma (HP:0000567)	1.81467742
79	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81217210
80	Chin dimple (HP:0010751)	1.80452411
81	Genetic anticipation (HP:0003743)	1.77539978
82	Severe visual impairment (HP:0001141)	1.77517265
83	Renal hypoplasia (HP:0000089)	1.75650687
84	Abnormality of the fovea (HP:0000493)	1.75105944
85	Anosmia (HP:0000458)	1.74218295
86	Postnatal microcephaly (HP:0005484)	1.72861572
87	Gastrointestinal atresia (HP:0002589)	1.72655347
88	Absent septum pellucidum (HP:0001331)	1.72501632
89	Horseshoe kidney (HP:0000085)	1.72415671
90	Patellar aplasia (HP:0006443)	1.71255183
91	Urinary urgency (HP:0000012)	1.70769282
92	Drooling (HP:0002307)	1.70543364
93	Lissencephaly (HP:0001339)	1.70422934
94	Progressive microcephaly (HP:0000253)	1.68663981
95	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.68147323
96	Broad distal phalanx of finger (HP:0009836)	1.67700160
97	Asplenia (HP:0001746)	1.67385763
98	Progressive inability to walk (HP:0002505)	1.65570344
99	Abnormality of B cell number (HP:0010975)	1.65475848
100	Broad foot (HP:0001769)	1.65469836

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.16544897
2	CDK19	6.06021272
3	BCKDK	3.89998759
4	EPHA4	3.11364697
5	SRPK1	2.32170238
6	BCR	2.28626279
7	MAPK13	2.06695025
8	SCYL2	1.98617773
9	PRKD3	1.95086462
10	ADRBK2	1.78199945
11	PLK2	1.66049378
12	MKNK1	1.65460436
13	MAP3K4	1.63977985
14	GRK7	1.60725414
15	CSNK1G3	1.57393692
16	CSNK1G2	1.52389140
17	TRIM28	1.49934671
18	NUAK1	1.47644159
19	UHMK1	1.45657222
20	PLK4	1.45531487
21	CSNK1A1L	1.43337184
22	WNK3	1.42584710
23	MAP2K7	1.39191600
24	RPS6KA4	1.38686470
25	TNIK	1.37008730
26	DYRK2	1.34882556
27	MKNK2	1.28357843
28	CDC7	1.27001058
29	FRK	1.21038296
30	CSNK1G1	1.21035320
31	DYRK3	1.19725410
32	NEK1	1.17488309
33	PBK	1.12770016
34	KIT	1.10198999
35	TIE1	1.08369651
36	BMPR1B	1.07554066
37	FLT3	1.05987147
38	MINK1	1.05904504
39	CCNB1	0.96054846
40	PLK3	0.91047573
41	MARK1	0.89605605
42	VRK1	0.86823946
43	KDR	0.84477521
44	VRK2	0.83321534
45	DYRK1B	0.82956039
46	CASK	0.80127286
47	TESK1	0.79316176
48	BRSK2	0.76958074
49	AURKA	0.76837336
50	CDK11A	0.76683135
51	MAP3K5	0.73674374
52	MAP2K4	0.73648536
53	ZAK	0.71831938
54	NTRK2	0.71766826
55	LIMK1	0.70203838
56	STK16	0.67015433
57	PLK1	0.65342153
58	PIK3CA	0.65253836
59	FGFR2	0.64922689
60	ATR	0.61837355
61	TSSK6	0.59842973
62	CDK14	0.58903757
63	BRSK1	0.58757211
64	ERBB3	0.57767522
65	RPS6KA5	0.54814883
66	CDK18	0.53466889
67	CDK3	0.51326091
68	BUB1	0.50925481
69	TAOK1	0.50785773
70	CDK15	0.49206053
71	CAMK2B	0.48645186
72	AKT2	0.47969278
73	CAMK2A	0.47905072
74	PRKCG	0.47626362
75	AURKB	0.46568065
76	MAP3K11	0.46380866
77	CSNK1A1	0.45832257
78	IRAK2	0.44517455
79	PIM2	0.43577090
80	DYRK1A	0.43348376
81	PINK1	0.43159932
82	PRKACB	0.41136195
83	FER	0.40887326
84	PRKCE	0.40275626
85	ADRBK1	0.38432543
86	CHEK2	0.38013248
87	TESK2	0.36411484
88	ATM	0.35762647
89	CSNK2A1	0.32031886
90	GRK1	0.31703249
91	CHEK1	0.31565796
92	PRKACA	0.31525944
93	WEE1	0.31145387
94	INSRR	0.30607335
95	OXSR1	0.29847112
96	TLK1	0.29822293
97	NTRK3	0.29393033
98	MATK	0.28639975
99	CSNK1D	0.27782122
100	GRK5	0.27687271

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.26199939
2	Protein export_Homo sapiens_hsa03060	2.58491597
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.56291097
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27336026
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.26778497
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.19414484
7	Phototransduction_Homo sapiens_hsa04744	2.10040846
8	Proteasome_Homo sapiens_hsa03050	2.05987811
9	Spliceosome_Homo sapiens_hsa03040	1.99078669
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.98011018
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97415391
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.92097716
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87889784
14	Parkinsons disease_Homo sapiens_hsa05012	1.81176071
15	Propanoate metabolism_Homo sapiens_hsa00640	1.77173308
16	Taste transduction_Homo sapiens_hsa04742	1.74675411
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.73896960
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72931174
19	RNA polymerase_Homo sapiens_hsa03020	1.70892833
20	Butanoate metabolism_Homo sapiens_hsa00650	1.69467629
21	Homologous recombination_Homo sapiens_hsa03440	1.68512161
22	GABAergic synapse_Homo sapiens_hsa04727	1.66457239
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.63113641
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.61002202
25	Base excision repair_Homo sapiens_hsa03410	1.60188205
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.58743627
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58568436
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.53295257
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.52230361
30	DNA replication_Homo sapiens_hsa03030	1.50327250
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.41366325
32	RNA transport_Homo sapiens_hsa03013	1.41205537
33	One carbon pool by folate_Homo sapiens_hsa00670	1.38766042
34	Fatty acid elongation_Homo sapiens_hsa00062	1.31923916
35	Huntingtons disease_Homo sapiens_hsa05016	1.28717228
36	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.26270095
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25718299
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24729007
39	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.23445130
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20934118
41	Peroxisome_Homo sapiens_hsa04146	1.12236757
42	Ribosome_Homo sapiens_hsa03010	1.12173021
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11945406
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.11608204
45	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.11541086
46	Mismatch repair_Homo sapiens_hsa03430	1.10016734
47	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.09648995
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.07376575
49	Pyruvate metabolism_Homo sapiens_hsa00620	1.05427598
50	Renin-angiotensin system_Homo sapiens_hsa04614	1.05364121
51	Morphine addiction_Homo sapiens_hsa05032	1.05278751
52	RNA degradation_Homo sapiens_hsa03018	1.04192706
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01198027
54	Retinol metabolism_Homo sapiens_hsa00830	0.93939992
55	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.93406567
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.92700842
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92132245
58	Purine metabolism_Homo sapiens_hsa00230	0.90828828
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.90300794
60	Carbon metabolism_Homo sapiens_hsa01200	0.88493201
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87705656
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86492374
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.84504634
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82987924
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82956151
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82337759
67	Alzheimers disease_Homo sapiens_hsa05010	0.81149424
68	Metabolic pathways_Homo sapiens_hsa01100	0.81110784
69	Folate biosynthesis_Homo sapiens_hsa00790	0.80577371
70	Basal transcription factors_Homo sapiens_hsa03022	0.79878871
71	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.79158030
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.76096895
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.71603699
74	Alcoholism_Homo sapiens_hsa05034	0.70733076
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70311340
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.68813821
77	Cell cycle_Homo sapiens_hsa04110	0.65720314
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64405096
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64391564
80	Glutathione metabolism_Homo sapiens_hsa00480	0.60977833
81	Axon guidance_Homo sapiens_hsa04360	0.59877092
82	p53 signaling pathway_Homo sapiens_hsa04115	0.59666047
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58315557
84	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56764698
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55119720
86	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.49006764
87	Caffeine metabolism_Homo sapiens_hsa00232	0.48683476
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.46923320
89	Salivary secretion_Homo sapiens_hsa04970	0.45487563
90	Sulfur relay system_Homo sapiens_hsa04122	0.42747415
91	Olfactory transduction_Homo sapiens_hsa04740	0.42116649
92	Regulation of autophagy_Homo sapiens_hsa04140	0.41710323
93	Cocaine addiction_Homo sapiens_hsa05030	0.41446582
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.39591771
95	Oocyte meiosis_Homo sapiens_hsa04114	0.38569482
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38287009
97	Circadian entrainment_Homo sapiens_hsa04713	0.35465536
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.34762800
99	Fatty acid degradation_Homo sapiens_hsa00071	0.33881930
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33059355

CENPVP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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