

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.89845081 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.80899092 |
| 3 | chaperone-mediated protein transport (GO:0072321) | 5.69479044 |
| 4 | viral transcription (GO:0019083) | 5.38652843 |
| 5 | DNA deamination (GO:0045006) | 5.31571933 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 5.30035357 |
| 7 | translational termination (GO:0006415) | 5.25161104 |
| 8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.24748027 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 5.21142066 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.21142066 |
| 11 | maturation of SSU-rRNA (GO:0030490) | 5.05010828 |
| 12 | telomere maintenance via semi-conservative replication (GO:0032201) | 5.01357955 |
| 13 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.92638650 |
| 14 | * CENP-A containing nucleosome assembly (GO:0034080) | 4.76643894 |
| 15 | DNA strand elongation (GO:0022616) | 4.71298278 |
| 16 | * chromatin remodeling at centromere (GO:0031055) | 4.70808300 |
| 17 | translational elongation (GO:0006414) | 4.65127451 |
| 18 | ribosomal large subunit biogenesis (GO:0042273) | 4.58728469 |
| 19 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.58318385 |
| 20 | telomere maintenance via recombination (GO:0000722) | 4.54082964 |
| 21 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.51013353 |
| 22 | cotranslational protein targeting to membrane (GO:0006613) | 4.49520396 |
| 23 | protein targeting to ER (GO:0045047) | 4.45932158 |
| 24 | DNA replication checkpoint (GO:0000076) | 4.42939584 |
| 25 | DNA replication initiation (GO:0006270) | 4.35612667 |
| 26 | translational initiation (GO:0006413) | 4.32937647 |
| 27 | mitotic recombination (GO:0006312) | 4.27608223 |
| 28 | regulation of mitochondrial translation (GO:0070129) | 4.25335299 |
| 29 | respiratory electron transport chain (GO:0022904) | 4.25142660 |
| 30 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.23412203 |
| 31 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.22530766 |
| 32 | protein localization to endoplasmic reticulum (GO:0070972) | 4.19346540 |
| 33 | cellular protein complex disassembly (GO:0043624) | 4.16584198 |
| 34 | mitotic metaphase plate congression (GO:0007080) | 4.15194330 |
| 35 | electron transport chain (GO:0022900) | 4.13879393 |
| 36 | * DNA replication-independent nucleosome organization (GO:0034724) | 4.11974517 |
| 37 | * DNA replication-independent nucleosome assembly (GO:0006336) | 4.11974517 |
| 38 | protein localization to kinetochore (GO:0034501) | 4.10653955 |
| 39 | viral life cycle (GO:0019058) | 4.07644526 |
| 40 | * kinetochore organization (GO:0051383) | 4.07543957 |
| 41 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.05986674 |
| 42 | telomere maintenance via telomere lengthening (GO:0010833) | 3.93850601 |
| 43 | protein complex biogenesis (GO:0070271) | 3.91186831 |
| 44 | * histone exchange (GO:0043486) | 3.90564127 |
| 45 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.88926584 |
| 46 | spliceosomal snRNP assembly (GO:0000387) | 3.88245924 |
| 47 | proteasome assembly (GO:0043248) | 3.86374038 |
| 48 | protein localization to chromosome, centromeric region (GO:0071459) | 3.82261662 |
| 49 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.81185218 |
| 50 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.80360070 |
| 51 | NADH dehydrogenase complex assembly (GO:0010257) | 3.80360070 |
| 52 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.80360070 |
| 53 | * kinetochore assembly (GO:0051382) | 3.80212134 |
| 54 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.79001203 |
| 55 | formation of translation preinitiation complex (GO:0001731) | 3.77861440 |
| 56 | protein neddylation (GO:0045116) | 3.70484581 |
| 57 | protein complex disassembly (GO:0043241) | 3.70049818 |
| 58 | translation (GO:0006412) | 3.69997426 |
| 59 | rRNA modification (GO:0000154) | 3.64672856 |
| 60 | protein targeting to mitochondrion (GO:0006626) | 3.64029404 |
| 61 | nucleobase biosynthetic process (GO:0046112) | 3.64028223 |
| 62 | rRNA processing (GO:0006364) | 3.63866601 |
| 63 | metaphase plate congression (GO:0051310) | 3.63559539 |
| 64 | spliceosomal complex assembly (GO:0000245) | 3.62446235 |
| 65 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.58019573 |
| 66 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.58019573 |
| 67 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.56775533 |
| 68 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.55259800 |
| 69 | rRNA metabolic process (GO:0016072) | 3.54823178 |
| 70 | establishment of integrated proviral latency (GO:0075713) | 3.53986959 |
| 71 | purine nucleobase biosynthetic process (GO:0009113) | 3.52782036 |
| 72 | macromolecular complex disassembly (GO:0032984) | 3.52343559 |
| 73 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.52086297 |
| 74 | DNA unwinding involved in DNA replication (GO:0006268) | 3.51116514 |
| 75 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.51091288 |
| 76 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.49867196 |
| 77 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.44634053 |
| 78 | ribosome biogenesis (GO:0042254) | 3.43804442 |
| 79 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.43452974 |
| 80 | pseudouridine synthesis (GO:0001522) | 3.42981865 |
| 81 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.40020239 |
| 82 | establishment of chromosome localization (GO:0051303) | 3.37078083 |
| 83 | sister chromatid segregation (GO:0000819) | 3.36529820 |
| 84 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.35857161 |
| 85 | protein localization to mitochondrion (GO:0070585) | 3.35062042 |
| 86 | establishment of protein localization to mitochondrion (GO:0072655) | 3.34883762 |
| 87 | DNA ligation (GO:0006266) | 3.33237841 |
| 88 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.31542081 |
| 89 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31469388 |
| 90 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.27961613 |
| 91 | cellular component biogenesis (GO:0044085) | 3.27957553 |
| 92 | DNA damage response, detection of DNA damage (GO:0042769) | 3.27748263 |
| 93 | termination of RNA polymerase III transcription (GO:0006386) | 3.25335089 |
| 94 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.25335089 |
| 95 | mRNA catabolic process (GO:0006402) | 3.22876459 |
| 96 | viral mRNA export from host cell nucleus (GO:0046784) | 3.22765603 |
| 97 | mitotic nuclear envelope disassembly (GO:0007077) | 3.22500845 |
| 98 | mitotic sister chromatid segregation (GO:0000070) | 3.21935317 |
| 99 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.21928858 |
| 100 | negative regulation of ligase activity (GO:0051352) | 3.21468601 |
| 101 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.21468601 |
| 102 | oxidative phosphorylation (GO:0006119) | 3.20817861 |
| 103 | cullin deneddylation (GO:0010388) | 3.15050726 |
| 104 | RNA catabolic process (GO:0006401) | 3.14068149 |
| 105 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.13342867 |
| 106 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.12814487 |
| 107 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.12814487 |
| 108 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.12814487 |
| 109 | meiotic chromosome segregation (GO:0045132) | 3.12016374 |
| 110 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.10741112 |
| 111 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.10377413 |
| 112 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.10377413 |
| 113 | 7-methylguanosine mRNA capping (GO:0006370) | 3.09884225 |
| 114 | positive regulation of ligase activity (GO:0051351) | 3.08931183 |
| 115 | cell cycle G1/S phase transition (GO:0044843) | 3.08579032 |
| 116 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.08579032 |
| 117 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.08392219 |
| 118 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.08392219 |
| 119 | ribosome assembly (GO:0042255) | 3.06014891 |
| 120 | RNA capping (GO:0036260) | 3.05040351 |
| 121 | 7-methylguanosine RNA capping (GO:0009452) | 3.05040351 |
| 122 | spindle checkpoint (GO:0031577) | 3.04309836 |
| 123 | mitotic chromosome condensation (GO:0007076) | 2.99977502 |
| 124 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.98373244 |
| 125 | negative regulation of sister chromatid segregation (GO:0033046) | 2.98373244 |
| 126 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.98373244 |
| 127 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.98373244 |
| 128 | negative regulation of chromosome segregation (GO:0051985) | 2.96625112 |
| 129 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.96168672 |
| 130 | regulation of spindle organization (GO:0090224) | 2.94591092 |
| 131 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.93702511 |
| 132 | membrane disassembly (GO:0030397) | 2.92777556 |
| 133 | nuclear envelope disassembly (GO:0051081) | 2.92777556 |
| 134 | termination of RNA polymerase II transcription (GO:0006369) | 2.91566327 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.83985608 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.62714134 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.03592241 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.01574405 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.86648268 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.85742544 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.47586454 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.40045623 |
| 9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.37909251 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.22033855 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.16264517 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.11765445 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.11474154 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.08212388 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.96408866 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.89003127 |
| 17 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.66204020 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.56628794 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.56122938 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.44089314 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.44088071 |
| 22 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.42572588 |
| 23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.41704491 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35232484 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30317254 |
| 26 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.27295113 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.18375464 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17360437 |
| 29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.12091001 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12046902 |
| 31 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.05539329 |
| 32 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.04864911 |
| 33 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.01213869 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.97376514 |
| 35 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.92646246 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.92151849 |
| 37 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.88205838 |
| 38 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.82335718 |
| 39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.82221545 |
| 40 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.77368157 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.74052040 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70372208 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.69115998 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66574760 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.66495706 |
| 46 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.64074117 |
| 47 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.63719838 |
| 48 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.62421447 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61126508 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49896986 |
| 51 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.49293531 |
| 52 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.40277421 |
| 53 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37588825 |
| 54 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.34086139 |
| 55 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33939234 |
| 56 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.32789556 |
| 57 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.30623812 |
| 58 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.29590131 |
| 59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28588283 |
| 60 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.25457119 |
| 61 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22805607 |
| 62 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.21000181 |
| 63 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.19114429 |
| 64 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.18036802 |
| 65 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.14726860 |
| 66 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.12981973 |
| 67 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11722080 |
| 68 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.10271272 |
| 69 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.07789535 |
| 70 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07551326 |
| 71 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.06613990 |
| 72 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.06577539 |
| 73 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.03476934 |
| 74 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.03277530 |
| 75 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.03047697 |
| 76 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02360131 |
| 77 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.01734055 |
| 78 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.98955990 |
| 79 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.98880673 |
| 80 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.98620878 |
| 81 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.98342323 |
| 82 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.97039047 |
| 83 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96073983 |
| 84 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.95120038 |
| 85 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.93586126 |
| 86 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.92187419 |
| 87 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.89212398 |
| 88 | EWS_26573619_Chip-Seq_HEK293_Human | 0.87911665 |
| 89 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.87272468 |
| 90 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86552080 |
| 91 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.85468834 |
| 92 | MYC_22102868_ChIP-Seq_BL_Human | 0.84566201 |
| 93 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.84197884 |
| 94 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.82368689 |
| 95 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.81635691 |
| 96 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.81440074 |
| 97 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.79870333 |
| 98 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.78235439 |
| 99 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.77260159 |
| 100 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.76486942 |
| 101 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.74420862 |
| 102 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.74136503 |
| 103 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.73825610 |
| 104 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.73769781 |
| 105 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72288473 |
| 106 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.71860424 |
| 107 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.71376264 |
| 108 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.70971489 |
| 109 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.70000070 |
| 110 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.69545806 |
| 111 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.69445834 |
| 112 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.67353047 |
| 113 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.67251092 |
| 114 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.66143877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.00245801 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.87381076 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.86496680 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.73471589 |
| 5 | MP0003077_abnormal_cell_cycle | 4.27791749 |
| 6 | MP0008057_abnormal_DNA_replication | 4.05480027 |
| 7 | MP0008058_abnormal_DNA_repair | 3.63761166 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.06902557 |
| 9 | MP0008007_abnormal_cellular_replicative | 3.00091898 |
| 10 | MP0009379_abnormal_foot_pigmentation | 2.92633682 |
| 11 | MP0003123_paternal_imprinting | 2.56326819 |
| 12 | MP0003786_premature_aging | 2.15146918 |
| 13 | MP0000350_abnormal_cell_proliferation | 2.06958557 |
| 14 | MP0002396_abnormal_hematopoietic_system | 2.06838757 |
| 15 | MP0003718_maternal_effect | 2.01124550 |
| 16 | MP0009697_abnormal_copulation | 1.99619058 |
| 17 | MP0001730_embryonic_growth_arrest | 1.92430634 |
| 18 | MP0008877_abnormal_DNA_methylation | 1.89445519 |
| 19 | MP0000490_abnormal_crypts_of | 1.82915630 |
| 20 | MP0006292_abnormal_olfactory_placode | 1.75543253 |
| 21 | MP0001697_abnormal_embryo_size | 1.55634176 |
| 22 | MP0003315_abnormal_perineum_morphology | 1.55159165 |
| 23 | MP0002102_abnormal_ear_morphology | 1.52381083 |
| 24 | MP0000313_abnormal_cell_death | 1.50316242 |
| 25 | MP0003186_abnormal_redox_activity | 1.49841482 |
| 26 | MP0009333_abnormal_splenocyte_physiolog | 1.47128233 |
| 27 | MP0002234_abnormal_pharynx_morphology | 1.45583460 |
| 28 | MP0010307_abnormal_tumor_latency | 1.45380255 |
| 29 | MP0002210_abnormal_sex_determination | 1.42167202 |
| 30 | MP0002019_abnormal_tumor_incidence | 1.40741606 |
| 31 | MP0001672_abnormal_embryogenesis/_devel | 1.40453675 |
| 32 | MP0005380_embryogenesis_phenotype | 1.40453675 |
| 33 | MP0010030_abnormal_orbit_morphology | 1.38148211 |
| 34 | MP0002080_prenatal_lethality | 1.38143861 |
| 35 | MP0002132_abnormal_respiratory_system | 1.36752258 |
| 36 | MP0003880_abnormal_central_pattern | 1.35006860 |
| 37 | MP0002085_abnormal_embryonic_tissue | 1.29423749 |
| 38 | MP0001145_abnormal_male_reproductive | 1.23804626 |
| 39 | MP0003806_abnormal_nucleotide_metabolis | 1.23694142 |
| 40 | MP0001929_abnormal_gametogenesis | 1.23521686 |
| 41 | MP0001188_hyperpigmentation | 1.22270710 |
| 42 | MP0006072_abnormal_retinal_apoptosis | 1.20427256 |
| 43 | MP0003984_embryonic_growth_retardation | 1.19727448 |
| 44 | MP0005394_taste/olfaction_phenotype | 1.18346665 |
| 45 | MP0005499_abnormal_olfactory_system | 1.18346665 |
| 46 | MP0004808_abnormal_hematopoietic_stem | 1.17217850 |
| 47 | MP0002088_abnormal_embryonic_growth/wei | 1.15964294 |
| 48 | MP0001545_abnormal_hematopoietic_system | 1.14840768 |
| 49 | MP0005397_hematopoietic_system_phenotyp | 1.14840768 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 1.13005001 |
| 51 | MP0003567_abnormal_fetal_cardiomyocyte | 1.11300529 |
| 52 | MP0002160_abnormal_reproductive_system | 1.11054017 |
| 53 | MP0001293_anophthalmia | 1.10624403 |
| 54 | MP0000653_abnormal_sex_gland | 1.07822561 |
| 55 | MP0010352_gastrointestinal_tract_polyps | 1.06360673 |
| 56 | MP0003763_abnormal_thymus_physiology | 1.05941417 |
| 57 | MP0002697_abnormal_eye_size | 1.05694843 |
| 58 | MP0003941_abnormal_skin_development | 1.03928448 |
| 59 | MP0000703_abnormal_thymus_morphology | 1.03065757 |
| 60 | MP0002233_abnormal_nose_morphology | 1.02379701 |
| 61 | MP0004133_heterotaxia | 1.01009119 |
| 62 | MP0002086_abnormal_extraembryonic_tissu | 1.00327862 |
| 63 | MP0002084_abnormal_developmental_patter | 0.98610797 |
| 64 | MP0003890_abnormal_embryonic-extraembry | 0.98177019 |
| 65 | MP0002398_abnormal_bone_marrow | 0.98083380 |
| 66 | MP0003136_yellow_coat_color | 0.98076163 |
| 67 | MP0002722_abnormal_immune_system | 0.96493974 |
| 68 | MP0004197_abnormal_fetal_growth/weight/ | 0.95626549 |
| 69 | MP0001119_abnormal_female_reproductive | 0.91840469 |
| 70 | MP0008995_early_reproductive_senescence | 0.91288306 |
| 71 | MP0000858_altered_metastatic_potential | 0.90690034 |
| 72 | MP0005389_reproductive_system_phenotype | 0.89659748 |
| 73 | MP0005084_abnormal_gallbladder_morpholo | 0.89487412 |
| 74 | MP0000689_abnormal_spleen_morphology | 0.89420139 |
| 75 | MP0003121_genomic_imprinting | 0.88630666 |
| 76 | MP0005075_abnormal_melanosome_morpholog | 0.86066265 |
| 77 | MP0002938_white_spotting | 0.85468995 |
| 78 | MP0001764_abnormal_homeostasis | 0.84026939 |
| 79 | MP0002095_abnormal_skin_pigmentation | 0.83988641 |
| 80 | MP0005174_abnormal_tail_pigmentation | 0.83506176 |
| 81 | MP0003656_abnormal_erythrocyte_physiolo | 0.83452626 |
| 82 | MP0002736_abnormal_nociception_after | 0.81905566 |
| 83 | MP0005187_abnormal_penis_morphology | 0.81647781 |
| 84 | MP0002429_abnormal_blood_cell | 0.80062623 |
| 85 | MP0001853_heart_inflammation | 0.79672090 |
| 86 | MP0009250_abnormal_appendicular_skeleto | 0.77885273 |
| 87 | MP0000647_abnormal_sebaceous_gland | 0.77753463 |
| 88 | MP0000566_synostosis | 0.77159222 |
| 89 | MP0000358_abnormal_cell_content/ | 0.76615076 |
| 90 | MP0000631_abnormal_neuroendocrine_gland | 0.75929321 |
| 91 | MP0001529_abnormal_vocalization | 0.75304011 |
| 92 | MP0001485_abnormal_pinna_reflex | 0.74951312 |
| 93 | MP0006035_abnormal_mitochondrial_morpho | 0.74303017 |
| 94 | MP0003755_abnormal_palate_morphology | 0.72837668 |
| 95 | MP0003698_abnormal_male_reproductive | 0.72684374 |
| 96 | MP0001986_abnormal_taste_sensitivity | 0.72676998 |
| 97 | MP0000537_abnormal_urethra_morphology | 0.71947187 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.71823777 |
| 99 | MP0002092_abnormal_eye_morphology | 0.71515654 |
| 100 | MP0000049_abnormal_middle_ear | 0.70499797 |
| 101 | MP0003119_abnormal_digestive_system | 0.69252392 |
| 102 | MP0006054_spinal_hemorrhage | 0.68579217 |
| 103 | MP0005379_endocrine/exocrine_gland_phen | 0.68067681 |
| 104 | MP0004147_increased_porphyrin_level | 0.66957061 |
| 105 | MP0002111_abnormal_tail_morphology | 0.66817844 |
| 106 | MP0003942_abnormal_urinary_system | 0.64812086 |
| 107 | MP0005391_vision/eye_phenotype | 0.64689402 |
| 108 | MP0002163_abnormal_gland_morphology | 0.64415176 |
| 109 | MP0003937_abnormal_limbs/digits/tail_de | 0.63650844 |
| 110 | MP0000716_abnormal_immune_system | 0.63493807 |
| 111 | MP0003938_abnormal_ear_development | 0.62132510 |
| 112 | MP0008789_abnormal_olfactory_epithelium | 0.62127412 |
| 113 | MP0005395_other_phenotype | 0.61280757 |
| 114 | MP0003861_abnormal_nervous_system | 0.60738408 |
| 115 | MP0001346_abnormal_lacrimal_gland | 0.60388095 |
| 116 | MP0002638_abnormal_pupillary_reflex | 0.59949018 |
| 117 | MP0009053_abnormal_anal_canal | 0.59685872 |
| 118 | MP0002177_abnormal_outer_ear | 0.59587651 |
| 119 | MP0003385_abnormal_body_wall | 0.58809680 |
| 120 | MP0001919_abnormal_reproductive_system | 0.58747996 |
| 121 | MP0005408_hypopigmentation | 0.58488388 |
| 122 | MP0005266_abnormal_metabolism | 0.58472517 |
| 123 | MP0001286_abnormal_eye_development | 0.58243868 |
| 124 | MP0002277_abnormal_respiratory_mucosa | 0.55840175 |
| 125 | MP0000372_irregular_coat_pigmentation | 0.55587532 |
| 126 | MP0002161_abnormal_fertility/fecundity | 0.55083134 |
| 127 | MP0009672_abnormal_birth_weight | 0.53798101 |
| 128 | MP0005384_cellular_phenotype | 0.53657951 |
| 129 | MP0003221_abnormal_cardiomyocyte_apopto | 0.50622001 |
| 130 | MP0002405_respiratory_system_inflammati | 0.48916276 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.97279077 |
| 2 | Reticulocytopenia (HP:0001896) | 5.92575106 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 5.79138157 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.89095701 |
| 5 | Breast hypoplasia (HP:0003187) | 4.36110900 |
| 6 | Macrocytic anemia (HP:0001972) | 4.29591909 |
| 7 | Pallor (HP:0000980) | 4.00483542 |
| 8 | Oral leukoplakia (HP:0002745) | 3.99878768 |
| 9 | Cerebral edema (HP:0002181) | 3.67249719 |
| 10 | Aplastic anemia (HP:0001915) | 3.54643081 |
| 11 | Chromsome breakage (HP:0040012) | 3.48830600 |
| 12 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.41607308 |
| 13 | Carpal bone hypoplasia (HP:0001498) | 3.37588738 |
| 14 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.37183390 |
| 15 | Patellar aplasia (HP:0006443) | 3.22937784 |
| 16 | Colon cancer (HP:0003003) | 3.20278533 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 3.20096504 |
| 18 | Meckel diverticulum (HP:0002245) | 3.19164998 |
| 19 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.18829113 |
| 20 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.18829113 |
| 21 | Acute necrotizing encephalopathy (HP:0006965) | 3.12109430 |
| 22 | Rough bone trabeculation (HP:0100670) | 3.05085178 |
| 23 | Abnormality of the preputium (HP:0100587) | 3.04612916 |
| 24 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.04230288 |
| 25 | Abnormality of the ileum (HP:0001549) | 3.04132407 |
| 26 | Mitochondrial inheritance (HP:0001427) | 3.02504020 |
| 27 | Absent thumb (HP:0009777) | 2.92251556 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.90476668 |
| 29 | Abnormality of chromosome stability (HP:0003220) | 2.86910837 |
| 30 | Lactic acidosis (HP:0003128) | 2.85751195 |
| 31 | Increased CSF lactate (HP:0002490) | 2.84272502 |
| 32 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.82025707 |
| 33 | 11 pairs of ribs (HP:0000878) | 2.76833318 |
| 34 | Selective tooth agenesis (HP:0001592) | 2.75877206 |
| 35 | Leukodystrophy (HP:0002415) | 2.74659391 |
| 36 | Hepatocellular necrosis (HP:0001404) | 2.74111884 |
| 37 | Lipid accumulation in hepatocytes (HP:0006561) | 2.72369127 |
| 38 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.68921409 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.67863026 |
| 40 | Exertional dyspnea (HP:0002875) | 2.67236400 |
| 41 | Duplicated collecting system (HP:0000081) | 2.66909651 |
| 42 | Increased serum lactate (HP:0002151) | 2.62325984 |
| 43 | Horseshoe kidney (HP:0000085) | 2.59292350 |
| 44 | Premature graying of hair (HP:0002216) | 2.58956383 |
| 45 | Absent radius (HP:0003974) | 2.57644846 |
| 46 | Duodenal stenosis (HP:0100867) | 2.57136056 |
| 47 | Small intestinal stenosis (HP:0012848) | 2.57136056 |
| 48 | Triphalangeal thumb (HP:0001199) | 2.55202633 |
| 49 | Microretrognathia (HP:0000308) | 2.50534247 |
| 50 | Myelodysplasia (HP:0002863) | 2.50095945 |
| 51 | Abnormality of the anterior horn cell (HP:0006802) | 2.48398109 |
| 52 | Degeneration of anterior horn cells (HP:0002398) | 2.48398109 |
| 53 | Abnormal lung lobation (HP:0002101) | 2.47122587 |
| 54 | Progressive macrocephaly (HP:0004481) | 2.45770120 |
| 55 | Cleft eyelid (HP:0000625) | 2.45308410 |
| 56 | Pancytopenia (HP:0001876) | 2.43455983 |
| 57 | Acute encephalopathy (HP:0006846) | 2.42432983 |
| 58 | Bone marrow hypocellularity (HP:0005528) | 2.39713972 |
| 59 | Absent forearm bone (HP:0003953) | 2.38822749 |
| 60 | Aplasia involving forearm bones (HP:0009822) | 2.38822749 |
| 61 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.38751640 |
| 62 | Cerebral hypomyelination (HP:0006808) | 2.37917520 |
| 63 | 3-Methylglutaconic aciduria (HP:0003535) | 2.37122528 |
| 64 | Hepatic necrosis (HP:0002605) | 2.34577049 |
| 65 | Septo-optic dysplasia (HP:0100842) | 2.34006862 |
| 66 | Hyperglycinemia (HP:0002154) | 2.33217214 |
| 67 | Cellular immunodeficiency (HP:0005374) | 2.33190969 |
| 68 | Abnormality of the renal collecting system (HP:0004742) | 2.30554181 |
| 69 | Type I transferrin isoform profile (HP:0003642) | 2.29097000 |
| 70 | Increased muscle lipid content (HP:0009058) | 2.28090285 |
| 71 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.27534121 |
| 72 | Abnormality of reticulocytes (HP:0004312) | 2.26403795 |
| 73 | Supernumerary spleens (HP:0009799) | 2.23172562 |
| 74 | Microvesicular hepatic steatosis (HP:0001414) | 2.23157126 |
| 75 | Thrombocytosis (HP:0001894) | 2.22060685 |
| 76 | Abnormal trabecular bone morphology (HP:0100671) | 2.21307359 |
| 77 | Abnormality of the labia minora (HP:0012880) | 2.20481494 |
| 78 | Optic disc pallor (HP:0000543) | 2.17813011 |
| 79 | Abnormal number of incisors (HP:0011064) | 2.16580878 |
| 80 | Trismus (HP:0000211) | 2.14943596 |
| 81 | Poor head control (HP:0002421) | 2.14886299 |
| 82 | Tracheoesophageal fistula (HP:0002575) | 2.13952021 |
| 83 | Exercise intolerance (HP:0003546) | 2.11711911 |
| 84 | Neoplasm of the pancreas (HP:0002894) | 2.08688220 |
| 85 | Increased intramyocellular lipid droplets (HP:0012240) | 2.08138700 |
| 86 | Secondary amenorrhea (HP:0000869) | 2.07048578 |
| 87 | Impulsivity (HP:0100710) | 2.06625936 |
| 88 | Lethargy (HP:0001254) | 2.06098745 |
| 89 | Abnormality of the duodenum (HP:0002246) | 2.04011469 |
| 90 | Methylmalonic acidemia (HP:0002912) | 2.03785165 |
| 91 | Sloping forehead (HP:0000340) | 2.02673767 |
| 92 | Renal Fanconi syndrome (HP:0001994) | 2.00558279 |
| 93 | Respiratory difficulties (HP:0002880) | 2.00193664 |
| 94 | Abnormality of methionine metabolism (HP:0010901) | 1.99669915 |
| 95 | Abnormality of renal resorption (HP:0011038) | 1.99059493 |
| 96 | Abnormality of serum amino acid levels (HP:0003112) | 1.98484853 |
| 97 | Atresia of the external auditory canal (HP:0000413) | 1.97898044 |
| 98 | Multiple enchondromatosis (HP:0005701) | 1.97650614 |
| 99 | Hypoplasia of the radius (HP:0002984) | 1.97067310 |
| 100 | Medulloblastoma (HP:0002885) | 1.95911307 |
| 101 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.95611566 |
| 102 | Abnormal spermatogenesis (HP:0008669) | 1.94919493 |
| 103 | Methylmalonic aciduria (HP:0012120) | 1.94249691 |
| 104 | Megaloblastic anemia (HP:0001889) | 1.93507085 |
| 105 | Hypoplastic pelvis (HP:0008839) | 1.92404452 |
| 106 | Sparse eyelashes (HP:0000653) | 1.92210515 |
| 107 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.90923323 |
| 108 | Depressed nasal ridge (HP:0000457) | 1.90463481 |
| 109 | Respiratory failure (HP:0002878) | 1.89478754 |
| 110 | Agnosia (HP:0010524) | 1.87666887 |
| 111 | Irregular epiphyses (HP:0010582) | 1.87469935 |
| 112 | Premature ovarian failure (HP:0008209) | 1.86307078 |
| 113 | Muscle fiber atrophy (HP:0100295) | 1.85976693 |
| 114 | Increased serum pyruvate (HP:0003542) | 1.84676723 |
| 115 | Abnormality of glycolysis (HP:0004366) | 1.84676723 |
| 116 | Abnormality of abdominal situs (HP:0011620) | 1.83127432 |
| 117 | Absent septum pellucidum (HP:0001331) | 1.82787208 |
| 118 | X-linked dominant inheritance (HP:0001423) | 1.79818417 |
| 119 | Stenosis of the external auditory canal (HP:0000402) | 1.79511318 |
| 120 | Abnormality of the carotid arteries (HP:0005344) | 1.78616717 |
| 121 | Ectopic kidney (HP:0000086) | 1.77404813 |
| 122 | CNS demyelination (HP:0007305) | 1.76654684 |
| 123 | Reduced antithrombin III activity (HP:0001976) | 1.76160528 |
| 124 | Facial cleft (HP:0002006) | 1.73803884 |
| 125 | Abnormality of alanine metabolism (HP:0010916) | 1.72366527 |
| 126 | Hyperalaninemia (HP:0003348) | 1.72366527 |
| 127 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.72366527 |
| 128 | Sclerocornea (HP:0000647) | 1.71179415 |
| 129 | Amniotic constriction ring (HP:0009775) | 1.67203266 |
| 130 | Abnormality of placental membranes (HP:0011409) | 1.67203266 |
| 131 | Abnormal glycosylation (HP:0012345) | 1.65060408 |
| 132 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.65060408 |
| 133 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.65060408 |
| 134 | Abnormal protein glycosylation (HP:0012346) | 1.65060408 |
| 135 | Short middle phalanx of the 5th finger (HP:0004220) | 1.65042023 |
| 136 | Short thumb (HP:0009778) | 1.64006420 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.95160765 |
| 2 | VRK2 | 4.73620545 |
| 3 | WEE1 | 4.47539953 |
| 4 | EIF2AK1 | 3.98722221 |
| 5 | CDC7 | 3.77539692 |
| 6 | SRPK1 | 3.20566111 |
| 7 | NME2 | 3.11748798 |
| 8 | TLK1 | 3.03871772 |
| 9 | PLK4 | 2.94672410 |
| 10 | STK16 | 2.70932516 |
| 11 | NEK2 | 2.60156424 |
| 12 | VRK1 | 2.56722732 |
| 13 | TAF1 | 2.32899698 |
| 14 | BRSK2 | 2.32661923 |
| 15 | EIF2AK3 | 2.09707700 |
| 16 | TTK | 2.07769047 |
| 17 | PLK1 | 2.07156160 |
| 18 | ACVR1B | 2.05184701 |
| 19 | TESK2 | 2.02225209 |
| 20 | PBK | 1.89759871 |
| 21 | AURKB | 1.72219050 |
| 22 | MKNK1 | 1.72206066 |
| 23 | NEK1 | 1.71506404 |
| 24 | NUAK1 | 1.70547928 |
| 25 | CCNB1 | 1.69260183 |
| 26 | DYRK3 | 1.66662200 |
| 27 | PDK2 | 1.56783861 |
| 28 | BRSK1 | 1.55786355 |
| 29 | CDK7 | 1.51957400 |
| 30 | ATR | 1.41321831 |
| 31 | MKNK2 | 1.38162453 |
| 32 | AURKA | 1.37450675 |
| 33 | PLK3 | 1.33168457 |
| 34 | RPS6KA4 | 1.31437064 |
| 35 | CHEK2 | 1.31074410 |
| 36 | CDK8 | 1.24592633 |
| 37 | NME1 | 1.20555272 |
| 38 | TSSK6 | 1.19122717 |
| 39 | PIM2 | 1.18107107 |
| 40 | EIF2AK2 | 1.09330382 |
| 41 | ZAK | 1.08716838 |
| 42 | MAP3K8 | 1.08314028 |
| 43 | RPS6KB2 | 1.01089043 |
| 44 | TRIM28 | 1.00992659 |
| 45 | CDK4 | 1.00648948 |
| 46 | STK4 | 0.99723742 |
| 47 | TNIK | 0.94800325 |
| 48 | CHEK1 | 0.91548055 |
| 49 | KDR | 0.91331989 |
| 50 | TESK1 | 0.90813306 |
| 51 | PAK4 | 0.90006212 |
| 52 | BMPR1B | 0.88413473 |
| 53 | BRAF | 0.86933363 |
| 54 | CDK19 | 0.85305271 |
| 55 | SMG1 | 0.83969606 |
| 56 | ARAF | 0.83037374 |
| 57 | PASK | 0.81325358 |
| 58 | CSNK1G3 | 0.80723697 |
| 59 | CSNK2A1 | 0.79282581 |
| 60 | WNK3 | 0.78795444 |
| 61 | ABL2 | 0.74978699 |
| 62 | CSNK2A2 | 0.72359617 |
| 63 | STK10 | 0.72099532 |
| 64 | CSNK1G1 | 0.69257646 |
| 65 | ATM | 0.68518325 |
| 66 | PIM1 | 0.66029484 |
| 67 | PAK1 | 0.65950002 |
| 68 | MAP3K10 | 0.65743190 |
| 69 | DYRK2 | 0.65479969 |
| 70 | CSNK1G2 | 0.63345973 |
| 71 | MAP3K12 | 0.61800890 |
| 72 | CDK2 | 0.61275128 |
| 73 | SCYL2 | 0.60068805 |
| 74 | CLK1 | 0.58942690 |
| 75 | MAP3K11 | 0.58843974 |
| 76 | MAP4K2 | 0.54947052 |
| 77 | PLK2 | 0.54765632 |
| 78 | CSNK1A1L | 0.54720789 |
| 79 | RPS6KA5 | 0.54487574 |
| 80 | OXSR1 | 0.54285433 |
| 81 | TEC | 0.53975902 |
| 82 | CDK1 | 0.50263180 |
| 83 | STK3 | 0.48125142 |
| 84 | IRAK4 | 0.47918917 |
| 85 | MINK1 | 0.46624300 |
| 86 | STK38L | 0.46552721 |
| 87 | MELK | 0.46154316 |
| 88 | LRRK2 | 0.45050107 |
| 89 | EPHA2 | 0.44452853 |
| 90 | MAPKAPK5 | 0.41841919 |
| 91 | BLK | 0.41610194 |
| 92 | TGFBR1 | 0.40957954 |
| 93 | MAP2K7 | 0.40829850 |
| 94 | BCKDK | 0.40501461 |
| 95 | YES1 | 0.40131312 |
| 96 | PRKCI | 0.39669984 |
| 97 | MST4 | 0.39483785 |
| 98 | MAP4K1 | 0.39283974 |
| 99 | CDK14 | 0.37777840 |
| 100 | CDK15 | 0.37757024 |
| 101 | CDK18 | 0.37604068 |
| 102 | ILK | 0.36086255 |
| 103 | GRK1 | 0.34546347 |
| 104 | IRAK3 | 0.33969278 |
| 105 | STK39 | 0.32617611 |
| 106 | CDK3 | 0.31978114 |
| 107 | BTK | 0.29583089 |
| 108 | WNK4 | 0.28994954 |
| 109 | LIMK1 | 0.28640076 |
| 110 | DMPK | 0.28002233 |
| 111 | CDK6 | 0.27592557 |
| 112 | TAOK2 | 0.25341560 |
| 113 | PDK3 | 0.25338045 |
| 114 | PDK4 | 0.25338045 |
| 115 | LYN | 0.25284589 |
| 116 | DAPK3 | 0.24564050 |
| 117 | MAP2K3 | 0.22690892 |
| 118 | FLT3 | 0.21339242 |
| 119 | MARK3 | 0.20322836 |
| 120 | PRKDC | 0.19790328 |
| 121 | CDK11A | 0.19232090 |
| 122 | IKBKB | 0.19144292 |
| 123 | AKT2 | 0.18431941 |
| 124 | PNCK | 0.16709371 |
| 125 | TXK | 0.15742950 |
| 126 | LATS2 | 0.14780049 |
| 127 | DAPK1 | 0.13775268 |
| 128 | GRK6 | 0.13775114 |
| 129 | CSNK1E | 0.12246427 |
| 130 | MUSK | 0.12119371 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.03517856 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 5.03412392 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.22765785 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.79264202 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.60888486 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.35614983 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 3.32099302 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.26583602 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.89672005 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.82708009 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.79436418 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.67184905 |
| 13 | Cell cycle_Homo sapiens_hsa04110 | 2.42237693 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.40171078 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.23226686 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.90930247 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.90596749 |
| 18 | Parkinsons disease_Homo sapiens_hsa05012 | 1.78705445 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.77414365 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.75893104 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.68621227 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.61291894 |
| 23 | Protein export_Homo sapiens_hsa03060 | 1.56009856 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.51868784 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.40982290 |
| 26 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.37806017 |
| 27 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.30116065 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.23317367 |
| 29 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.21080258 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.05632565 |
| 31 | Alzheimers disease_Homo sapiens_hsa05010 | 1.01868129 |
| 32 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.00088524 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.96366903 |
| 34 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.91816440 |
| 35 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.89750710 |
| 36 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.85975936 |
| 37 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83284931 |
| 38 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.81942897 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.78137049 |
| 40 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.76960751 |
| 41 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.76609451 |
| 42 | Sulfur relay system_Homo sapiens_hsa04122 | 0.73896191 |
| 43 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.73700325 |
| 44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.72227511 |
| 45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.71602878 |
| 46 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.69494145 |
| 47 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.69479286 |
| 48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.68394612 |
| 49 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.67163539 |
| 50 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.67157326 |
| 51 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.64753766 |
| 52 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.63667930 |
| 53 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.63164983 |
| 54 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.55791235 |
| 55 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.54303739 |
| 56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.53864934 |
| 57 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.53720500 |
| 58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.50873438 |
| 59 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.48319697 |
| 60 | HTLV-I infection_Homo sapiens_hsa05166 | 0.48184233 |
| 61 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.46759402 |
| 62 | Peroxisome_Homo sapiens_hsa04146 | 0.43443420 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.40269994 |
| 64 | Legionellosis_Homo sapiens_hsa05134 | 0.39126446 |
| 65 | Alcoholism_Homo sapiens_hsa05034 | 0.38591606 |
| 66 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35738334 |
| 67 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.35288718 |
| 68 | Carbon metabolism_Homo sapiens_hsa01200 | 0.34741009 |
| 69 | Thyroid cancer_Homo sapiens_hsa05216 | 0.34408221 |
| 70 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33827766 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.32428034 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.31874969 |
| 73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.31407709 |
| 74 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.29944937 |
| 75 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.29708155 |
| 76 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.28547648 |
| 77 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.28198845 |
| 78 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.27857001 |
| 79 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27418217 |
| 80 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.26383332 |
| 81 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.25799774 |
| 82 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.25331424 |
| 83 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24804534 |
| 84 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.22432288 |
| 85 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.21792954 |
| 86 | Allograft rejection_Homo sapiens_hsa05330 | 0.21462157 |
| 87 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.20697017 |
| 88 | Measles_Homo sapiens_hsa05162 | 0.20544970 |
| 89 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.20510388 |
| 90 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.20219674 |
| 91 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.19277855 |
| 92 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.19236382 |
| 93 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.19210202 |
| 94 | Apoptosis_Homo sapiens_hsa04210 | 0.19161265 |
| 95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.19102580 |
| 96 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.18090476 |
| 97 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.17928840 |
| 98 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.17700674 |
| 99 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.17529140 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.17055803 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.16940012 |
| 102 | Retinol metabolism_Homo sapiens_hsa00830 | 0.16488605 |
| 103 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.16271630 |
| 104 | Phototransduction_Homo sapiens_hsa04744 | 0.16211063 |
| 105 | Hepatitis B_Homo sapiens_hsa05161 | 0.14992422 |
| 106 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.14747666 |
| 107 | Galactose metabolism_Homo sapiens_hsa00052 | 0.14392029 |
| 108 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.13860653 |
| 109 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.13793082 |
| 110 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.13617825 |
| 111 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.13607957 |
| 112 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.12078850 |
| 113 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.11979032 |
| 114 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.11974437 |
| 115 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.11803788 |
| 116 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.11654867 |
| 117 | Asthma_Homo sapiens_hsa05310 | 0.11489317 |
| 118 | Shigellosis_Homo sapiens_hsa05131 | 0.11146544 |
| 119 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.10057432 |
| 120 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.09546922 |
| 121 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.09169912 |
| 122 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.08120758 |
| 123 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.07869903 |
| 124 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.07485182 |
| 125 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.06971192 |
| 126 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.06484519 |
| 127 | Influenza A_Homo sapiens_hsa05164 | 0.05088785 |
| 128 | Colorectal cancer_Homo sapiens_hsa05210 | 0.04506983 |
| 129 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.04223892 |
| 130 | Pathways in cancer_Homo sapiens_hsa05200 | 0.04116815 |
| 131 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.03892545 |
| 132 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.03731517 |
| 133 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.03360015 |
| 134 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.02768334 |

