CEP135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.02334653
2nuclear pore complex assembly (GO:0051292)4.80861943
3nuclear pore organization (GO:0006999)4.79256752
4mitotic sister chromatid cohesion (GO:0007064)4.76424982
5regulation of centriole replication (GO:0046599)4.60238264
6mitotic chromosome condensation (GO:0007076)4.51769370
7replication fork processing (GO:0031297)4.41961527
8protein localization to kinetochore (GO:0034501)4.39962070
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.39487507
10regulation of DNA endoreduplication (GO:0032875)4.36807019
11kinetochore assembly (GO:0051382)4.22758115
12meiotic chromosome segregation (GO:0045132)4.17617519
13mitotic metaphase plate congression (GO:0007080)4.12071873
14metaphase plate congression (GO:0051310)4.08376634
15protein localization to chromosome, centromeric region (GO:0071459)4.03229734
16DNA ligation (GO:0006266)4.02418766
17positive regulation of mitotic sister chromatid separation (GO:1901970)4.00196768
18positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.00196768
19positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.00196768
20sister chromatid segregation (GO:0000819)3.86545894
21regulation of sister chromatid cohesion (GO:0007063)3.84187976
22rRNA catabolic process (GO:0016075)3.75162092
23DNA double-strand break processing (GO:0000729)3.73091439
24pre-miRNA processing (GO:0031054)3.72765330
25establishment of chromosome localization (GO:0051303)3.72147744
26attachment of spindle microtubules to kinetochore (GO:0008608)3.68260699
27mitotic sister chromatid segregation (GO:0000070)3.66942540
28pore complex assembly (GO:0046931)3.66632375
29CENP-A containing nucleosome assembly (GO:0034080)3.65735212
30recombinational repair (GO:0000725)3.63546662
31chromatin remodeling at centromere (GO:0031055)3.56967952
32histone H3-K9 methylation (GO:0051567)3.56362268
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.55174652
34double-strand break repair via homologous recombination (GO:0000724)3.54709659
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.48728941
36regulation of translation, ncRNA-mediated (GO:0045974)3.48728941
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48728941
38DNA replication-independent nucleosome assembly (GO:0006336)3.47029346
39DNA replication-independent nucleosome organization (GO:0034724)3.47029346
40monoubiquitinated protein deubiquitination (GO:0035520)3.46953565
41negative regulation of histone methylation (GO:0031061)3.46034757
42mitotic nuclear envelope disassembly (GO:0007077)3.43793359
43DNA deamination (GO:0045006)3.43466871
44neural tube formation (GO:0001841)3.43253877
45regulation of histone H3-K9 methylation (GO:0051570)3.41705442
46histone exchange (GO:0043486)3.34403730
47positive regulation of chromosome segregation (GO:0051984)3.34297893
48microtubule depolymerization (GO:0007019)3.33350084
49regulation of spindle organization (GO:0090224)3.32521967
50regulation of centrosome cycle (GO:0046605)3.29974896
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.29292583
52regulation of mitotic spindle organization (GO:0060236)3.27597091
53* centriole assembly (GO:0098534)3.27165686
54chromatin assembly or disassembly (GO:0006333)3.26074368
55microtubule polymerization or depolymerization (GO:0031109)3.25449809
56sister chromatid cohesion (GO:0007062)3.25440698
57DNA geometric change (GO:0032392)3.24989679
58protein localization to chromosome (GO:0034502)3.24438835
59DNA unwinding involved in DNA replication (GO:0006268)3.23886694
60DNA duplex unwinding (GO:0032508)3.22762653
61histone H3-K9 modification (GO:0061647)3.22735018
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21023785
63membrane disassembly (GO:0030397)3.17834700
64nuclear envelope disassembly (GO:0051081)3.17834700
65dosage compensation (GO:0007549)3.16961829
66microtubule anchoring (GO:0034453)3.15248630
67mitotic recombination (GO:0006312)3.14612514
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.12934281
69chromosome condensation (GO:0030261)3.12375127
70chromosome segregation (GO:0007059)3.12289071
71synapsis (GO:0007129)3.09510144
72DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.07733578
73translesion synthesis (GO:0019985)3.06125899
74regulation of centrosome duplication (GO:0010824)3.05171540
75regulation of mitotic spindle checkpoint (GO:1903504)3.04209808
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04209808
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04082974
78reciprocal meiotic recombination (GO:0007131)3.02476230
79reciprocal DNA recombination (GO:0035825)3.02476230
80regulation of chromosome segregation (GO:0051983)3.02259136
81DNA packaging (GO:0006323)3.01079303
82telomere maintenance via recombination (GO:0000722)3.00696437
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00557499
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.00557499
85DNA conformation change (GO:0071103)2.99911511
86regulation of nuclear cell cycle DNA replication (GO:0033262)2.98086970
87peptidyl-lysine trimethylation (GO:0018023)2.97776234
88fucose catabolic process (GO:0019317)2.97023366
89L-fucose metabolic process (GO:0042354)2.97023366
90L-fucose catabolic process (GO:0042355)2.97023366
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96921259
92ATP-dependent chromatin remodeling (GO:0043044)2.96420457
93response to pheromone (GO:0019236)2.94301793
94intra-S DNA damage checkpoint (GO:0031573)2.93331561
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93042977
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92564201
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91781787
98* microtubule organizing center organization (GO:0031023)2.91655187
99behavioral response to nicotine (GO:0035095)2.91588312
100ncRNA catabolic process (GO:0034661)2.91356081
101histone-serine phosphorylation (GO:0035404)2.89852091
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89357458
103DNA topological change (GO:0006265)2.88757945
104resolution of meiotic recombination intermediates (GO:0000712)2.88072266
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88061640
106chromatin assembly (GO:0031497)2.85284186
107spindle checkpoint (GO:0031577)2.82754760
108DNA replication checkpoint (GO:0000076)2.82658035
109mitotic G2/M transition checkpoint (GO:0044818)2.82009525
110DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81289877
111regulation of sister chromatid segregation (GO:0033045)2.80418013
112regulation of mitotic sister chromatid separation (GO:0010965)2.80418013
113regulation of mitotic sister chromatid segregation (GO:0033047)2.80418013
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.79529086
115somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.79529086
116isotype switching (GO:0045190)2.79529086
117DNA catabolic process, exonucleolytic (GO:0000738)2.77779469
118DNA replication initiation (GO:0006270)2.77724293
119epithelial cilium movement (GO:0003351)2.76323478
120telomere maintenance (GO:0000723)2.75213666
121DNA strand elongation involved in DNA replication (GO:0006271)2.72658436
122mitotic spindle checkpoint (GO:0071174)2.71555451
123regulation of RNA export from nucleus (GO:0046831)2.71262281
124telomere organization (GO:0032200)2.70997775
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.70786046
126negative regulation of sister chromatid segregation (GO:0033046)2.70786046
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70786046
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70786046
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70786046
130DNA strand renaturation (GO:0000733)2.70586479
131cilium or flagellum-dependent cell motility (GO:0001539)2.69960014
132* centriole replication (GO:0007099)2.69873768
133DNA replication-dependent nucleosome assembly (GO:0006335)2.69019952
134DNA replication-dependent nucleosome organization (GO:0034723)2.69019952
135double-strand break repair (GO:0006302)2.68451558
136cytoplasmic mRNA processing body assembly (GO:0033962)2.67556561
137* centrosome organization (GO:0051297)2.67097049
138negative regulation by host of viral transcription (GO:0043922)2.67044130
139regulation of DNA-dependent DNA replication (GO:0090329)2.66318936
140interkinetic nuclear migration (GO:0022027)2.66229154
141DNA recombination (GO:0006310)2.65402069
142histone H3-K4 trimethylation (GO:0080182)2.65019939
143DNA strand elongation (GO:0022616)2.65012492
144protein K6-linked ubiquitination (GO:0085020)2.64861304
145negative regulation of DNA recombination (GO:0045910)2.64810107
146mismatch repair (GO:0006298)2.64493244
147histone mRNA catabolic process (GO:0071044)2.64384012
148DNA synthesis involved in DNA repair (GO:0000731)2.64174288
149spindle assembly checkpoint (GO:0071173)2.62711908
150chromosome organization (GO:0051276)2.61786230
151negative regulation of chromosome segregation (GO:0051985)2.61093343
152telomere maintenance via semi-conservative replication (GO:0032201)2.60558941
153protein-cofactor linkage (GO:0018065)2.56725784
154somatic diversification of immune receptors (GO:0002200)2.56477842
155mitotic spindle assembly checkpoint (GO:0007094)2.56007096
156tryptophan catabolic process (GO:0006569)2.55973684
157indolalkylamine catabolic process (GO:0046218)2.55973684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.91652410
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.77077028
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.73469072
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.70248842
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.27664688
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08111890
7ZNF274_21170338_ChIP-Seq_K562_Hela2.83604920
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74530490
9VDR_22108803_ChIP-Seq_LS180_Human2.72771278
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69640791
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.62252178
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48961575
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46897391
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44572342
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42378054
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.34314285
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.30897957
18TAF15_26573619_Chip-Seq_HEK293_Human2.23081973
19AR_21909140_ChIP-Seq_LNCAP_Human2.13138385
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.11433590
21MYC_22102868_ChIP-Seq_BL_Human2.08768598
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08273710
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08187485
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08062644
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.04989750
26E2F7_22180533_ChIP-Seq_HELA_Human11.5342898
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97869651
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95038660
29SCL_19346495_ChIP-Seq_HPC-7_Human1.92496364
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83458364
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83337713
32GBX2_23144817_ChIP-Seq_PC3_Human1.82926697
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81096588
34* P300_19829295_ChIP-Seq_ESCs_Human1.74054330
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71220560
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68103578
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64164952
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63840136
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63427986
40ER_23166858_ChIP-Seq_MCF-7_Human1.62960250
41CIITA_25753668_ChIP-Seq_RAJI_Human1.62665498
42MYC_18940864_ChIP-ChIP_HL60_Human1.61064590
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55925030
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53822120
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53244376
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51644976
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51418874
48MYB_26560356_Chip-Seq_TH1_Human1.50680467
49IRF1_19129219_ChIP-ChIP_H3396_Human1.48840566
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46407546
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44566322
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44566322
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41965941
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38533083
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37817940
56MYB_26560356_Chip-Seq_TH2_Human1.37338640
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35092692
58CBP_20019798_ChIP-Seq_JUKART_Human1.35092692
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34627695
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34473843
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34292398
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33097607
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32143269
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31679554
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.31569446
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30843585
67ELK1_19687146_ChIP-ChIP_HELA_Human1.29859643
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29338724
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.29284318
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.28591616
71FOXP3_21729870_ChIP-Seq_TREG_Human1.27002054
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26751635
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.22280228
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21648885
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21470958
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21342254
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20727934
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20478856
79STAT3_23295773_ChIP-Seq_U87_Human1.19293293
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.19285472
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18975035
82TP53_22573176_ChIP-Seq_HFKS_Human1.15793115
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15749494
84RUNX_20019798_ChIP-Seq_JUKART_Human1.15258942
85BCAT_22108803_ChIP-Seq_LS180_Human1.13717368
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.13403579
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12549413
88VDR_21846776_ChIP-Seq_THP-1_Human1.12189508
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10948965
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10143473
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09687572
92* TCF7_22412390_ChIP-Seq_EML_Mouse1.08292772
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08213997
94VDR_23849224_ChIP-Seq_CD4+_Human1.07706475
95* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06834538
96* FOXA1_25329375_ChIP-Seq_VCAP_Human1.06834538
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06718391
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04844878
99TCF4_23295773_ChIP-Seq_U87_Human1.04829170
100* SPI1_23547873_ChIP-Seq_NB4_Human1.04760163
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04098552
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04056839
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.03906047
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03733064
105UTX_26944678_Chip-Seq_JUKART_Human1.03688601
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02799776
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02176004
108* AR_25329375_ChIP-Seq_VCAP_Human1.01345221
109KDM5A_27292631_Chip-Seq_BREAST_Human1.01115632
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00924606
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00859688
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.00744061
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00436842
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00252486
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.98861199
116NANOG_19829295_ChIP-Seq_ESCs_Human0.98748429
117SOX2_19829295_ChIP-Seq_ESCs_Human0.98748429
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98698619
119AR_21572438_ChIP-Seq_LNCaP_Human0.98647748
120TCF4_22108803_ChIP-Seq_LS180_Human0.97987316
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.97652029
122* MAF_26560356_Chip-Seq_TH1_Human0.97642602
123SMAD4_21799915_ChIP-Seq_A2780_Human0.97384632
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96891245
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96601061
126GATA3_26560356_Chip-Seq_TH2_Human0.96414588
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96156045
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96007113
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95121743
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.94537839
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93686443
132TFEB_21752829_ChIP-Seq_HELA_Human0.93179872
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92325913
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.91853902
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91659136
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91059040
137P53_22387025_ChIP-Seq_ESCs_Mouse0.90940025
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90753522
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90109060
140PU_27001747_Chip-Seq_BMDM_Mouse0.88824816
141* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88323191
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87378418
143EWS_26573619_Chip-Seq_HEK293_Human0.87188452
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85967645
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85697306
146ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85474803
147* RUNX1_22412390_ChIP-Seq_EML_Mouse0.83273796
148ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81624287
149SPI1_23127762_ChIP-Seq_K562_Human0.80226323
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78012559
151RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76895574
152BRD4_25478319_ChIP-Seq_HGPS_Human0.76595178
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75228341
154RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73912934
155NANOG_18555785_ChIP-Seq_MESCs_Mouse0.73725326
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73195907
157VDR_24763502_ChIP-Seq_THP-1_Human0.72867422
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70262789
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.69262681
160TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69213788
161GATA3_27048872_Chip-Seq_THYMUS_Human0.68354777
162IGF1R_20145208_ChIP-Seq_DFB_Human0.67815133
163EST1_17652178_ChIP-ChIP_JURKAT_Human0.66599257
164RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65861186
165FUS_26573619_Chip-Seq_HEK293_Human0.63199863
166Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.62870608
167TTF2_22483619_ChIP-Seq_HELA_Human0.62445112
168SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.62212912
169FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.62155486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.09920561
2MP0010094_abnormal_chromosome_stability4.04107381
3MP0003111_abnormal_nucleus_morphology3.39318328
4MP0008057_abnormal_DNA_replication3.32679943
5MP0003077_abnormal_cell_cycle3.22166259
6MP0003693_abnormal_embryo_hatching3.04660382
7MP0008877_abnormal_DNA_methylation2.75175016
8MP0008058_abnormal_DNA_repair2.62474112
9MP0003136_yellow_coat_color2.60734249
10MP0002396_abnormal_hematopoietic_system2.57353577
11MP0010307_abnormal_tumor_latency2.51768350
12MP0008007_abnormal_cellular_replicative2.49155357
13MP0004808_abnormal_hematopoietic_stem2.44113068
14MP0003787_abnormal_imprinting2.35439341
15MP0005076_abnormal_cell_differentiation2.05969917
16MP0003121_genomic_imprinting1.97769736
17MP0004957_abnormal_blastocyst_morpholog1.95891716
18MP0003763_abnormal_thymus_physiology1.87738372
19MP0005174_abnormal_tail_pigmentation1.87342630
20MP0006072_abnormal_retinal_apoptosis1.87000088
21MP0001485_abnormal_pinna_reflex1.82750876
22MP0002837_dystrophic_cardiac_calcinosis1.78232970
23MP0000350_abnormal_cell_proliferation1.77113895
24MP0000015_abnormal_ear_pigmentation1.66725971
25MP0002398_abnormal_bone_marrow1.66350233
26MP0003718_maternal_effect1.63361628
27MP0001545_abnormal_hematopoietic_system1.63159549
28MP0005397_hematopoietic_system_phenotyp1.63159549
29MP0003195_calcinosis1.62256392
30MP0002653_abnormal_ependyma_morphology1.56779249
31MP0000703_abnormal_thymus_morphology1.53642326
32MP0010352_gastrointestinal_tract_polyps1.52235054
33MP0002736_abnormal_nociception_after1.51552043
34MP0009278_abnormal_bone_marrow1.50913514
35MP0000490_abnormal_crypts_of1.48821473
36MP0001800_abnormal_humoral_immune1.46859477
37MP0002938_white_spotting1.45748436
38MP0001730_embryonic_growth_arrest1.42636231
39MP0004885_abnormal_endolymph1.41999182
40MP0001672_abnormal_embryogenesis/_devel1.41641035
41MP0005380_embryogenesis_phenotype1.41641035
42MP0005253_abnormal_eye_physiology1.41392185
43MP0000371_diluted_coat_color1.39769605
44MP0005551_abnormal_eye_electrophysiolog1.38928815
45MP0005671_abnormal_response_to1.38836749
46MP0002095_abnormal_skin_pigmentation1.38230406
47MP0004142_abnormal_muscle_tone1.34479735
48MP0004742_abnormal_vestibular_system1.34096235
49MP0000427_abnormal_hair_cycle1.33675844
50MP0001835_abnormal_antigen_presentation1.33085103
51MP0008932_abnormal_embryonic_tissue1.32347681
52MP0003890_abnormal_embryonic-extraembry1.32006319
53MP0003123_paternal_imprinting1.31994527
54MP0000689_abnormal_spleen_morphology1.30851794
55MP0005646_abnormal_pituitary_gland1.26744901
56MP0003984_embryonic_growth_retardation1.26071177
57MP0001697_abnormal_embryo_size1.25957774
58MP0000631_abnormal_neuroendocrine_gland1.25605260
59MP0004197_abnormal_fetal_growth/weight/1.24523506
60MP0001929_abnormal_gametogenesis1.24214125
61MP0002166_altered_tumor_susceptibility1.24106682
62MP0002722_abnormal_immune_system1.24027055
63MP0002019_abnormal_tumor_incidence1.23806908
64MP0002086_abnormal_extraembryonic_tissu1.23187442
65MP0002088_abnormal_embryonic_growth/wei1.22627949
66MP0002452_abnormal_antigen_presenting1.22513196
67MP0004147_increased_porphyrin_level1.22127598
68MP0002210_abnormal_sex_determination1.21347471
69MP0002102_abnormal_ear_morphology1.21273921
70MP0000716_abnormal_immune_system1.21010632
71MP0000372_irregular_coat_pigmentation1.20386456
72MP0002163_abnormal_gland_morphology1.19511853
73MP0002084_abnormal_developmental_patter1.18209539
74MP0008872_abnormal_physiological_respon1.17650018
75MP0003943_abnormal_hepatobiliary_system1.17135950
76MP0001286_abnormal_eye_development1.16515618
77MP0000313_abnormal_cell_death1.15324049
78MP0001968_abnormal_touch/_nociception1.14064453
79MP0002420_abnormal_adaptive_immunity1.14059751
80MP0001819_abnormal_immune_cell1.12563947
81MP0003646_muscle_fatigue1.12055150
82MP0009697_abnormal_copulation1.11575162
83MP0002429_abnormal_blood_cell1.11435130
84MP0002277_abnormal_respiratory_mucosa1.11251450
85MP0008995_early_reproductive_senescence1.10619396
86MP0000685_abnormal_immune_system1.10572709
87MP0001790_abnormal_immune_system1.07751161
88MP0005387_immune_system_phenotype1.07751161
89MP0002006_tumorigenesis1.07600022
90MP0002075_abnormal_coat/hair_pigmentati1.07171909
91MP0002085_abnormal_embryonic_tissue1.06966111
92MP0003183_abnormal_peptide_metabolism1.06761152
93MP0005084_abnormal_gallbladder_morpholo1.06139334
94MP0001293_anophthalmia1.05841728
95MP0003950_abnormal_plasma_membrane1.04159119
96MP0002080_prenatal_lethality1.03789403
97MP0004133_heterotaxia1.02232909
98MP0002723_abnormal_immune_serum1.01935481
99MP0002234_abnormal_pharynx_morphology1.01287935
100MP0005408_hypopigmentation1.00004274
101MP0002928_abnormal_bile_duct0.99203065
102MP0002405_respiratory_system_inflammati0.96907706
103MP0002751_abnormal_autonomic_nervous0.96483254
104MP0009333_abnormal_splenocyte_physiolog0.96411995
105MP0005377_hearing/vestibular/ear_phenot0.95940606
106MP0003878_abnormal_ear_physiology0.95940606
107MP0005075_abnormal_melanosome_morpholog0.95740377
108MP0000049_abnormal_middle_ear0.95710622
109MP0000383_abnormal_hair_follicle0.95301220
110MP0001919_abnormal_reproductive_system0.94562073
111MP0001119_abnormal_female_reproductive0.93611174
112MP0009703_decreased_birth_body0.91972250
113MP0003567_abnormal_fetal_cardiomyocyte0.91873350
114MP0001145_abnormal_male_reproductive0.91759939
115MP0005391_vision/eye_phenotype0.90516184
116MP0002009_preneoplasia0.90077278
117MP0005389_reproductive_system_phenotype0.89465530
118MP0001915_intracranial_hemorrhage0.86763511
119MP0003938_abnormal_ear_development0.85980622
120MP0006035_abnormal_mitochondrial_morpho0.84483693
121MP0000653_abnormal_sex_gland0.84007160
122MP0002925_abnormal_cardiovascular_devel0.81428666
123MP0000733_abnormal_muscle_development0.80407244
124MP0005410_abnormal_fertilization0.79639761
125MP0003698_abnormal_male_reproductive0.79523353
126MP0002638_abnormal_pupillary_reflex0.78838079
127MP0000647_abnormal_sebaceous_gland0.78432287
128MP0005171_absent_coat_pigmentation0.77949948
129MP0000432_abnormal_head_morphology0.77838227
130MP0002160_abnormal_reproductive_system0.77418137
131MP0005000_abnormal_immune_tolerance0.76586441
132MP0005464_abnormal_platelet_physiology0.75804254
133MP0001348_abnormal_lacrimal_gland0.75500229
134MP0003119_abnormal_digestive_system0.74362823
135MP0003937_abnormal_limbs/digits/tail_de0.73756066
136MP0001764_abnormal_homeostasis0.72851569
137MP0005195_abnormal_posterior_eye0.71969021
138MP0002282_abnormal_trachea_morphology0.71539253
139MP0001186_pigmentation_phenotype0.71475778
140MP0003705_abnormal_hypodermis_morpholog0.70889638
141MP0009672_abnormal_birth_weight0.70506870
142MP0002419_abnormal_innate_immunity0.70354690
143MP0008961_abnormal_basal_metabolism0.70281326
144MP0006292_abnormal_olfactory_placode0.70230200
145MP0005621_abnormal_cell_physiology0.70006776
146MP0003786_premature_aging0.69410468
147MP0002233_abnormal_nose_morphology0.69135511
148MP0002877_abnormal_melanocyte_morpholog0.68864891
149MP0002138_abnormal_hepatobiliary_system0.68158155
150MP0001324_abnormal_eye_pigmentation0.67978575
151MP0001986_abnormal_taste_sensitivity0.67960860
152MP0005310_abnormal_salivary_gland0.66766534
153MP0000778_abnormal_nervous_system0.60701415

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.69110381
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.54591173
3Pancreatic cysts (HP:0001737)4.13201378
4Abnormality of the fingertips (HP:0001211)3.85581804
5True hermaphroditism (HP:0010459)3.79878894
6Pancreatic fibrosis (HP:0100732)3.77713188
7Abnormality of chromosome stability (HP:0003220)3.56576858
8Volvulus (HP:0002580)3.52124365
9Abnormality of midbrain morphology (HP:0002418)3.51461607
10Molar tooth sign on MRI (HP:0002419)3.51461607
11Ectopic kidney (HP:0000086)3.31439344
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.23376090
13Chronic hepatic failure (HP:0100626)3.13071716
14Abnormality of the labia minora (HP:0012880)3.05123651
15Meckel diverticulum (HP:0002245)3.01138406
16Abnormality of the renal cortex (HP:0011035)2.94983515
17Myelodysplasia (HP:0002863)2.88422727
18Abnormality of the ileum (HP:0001549)2.82290958
19Long eyelashes (HP:0000527)2.80249697
20Abnormality of the renal medulla (HP:0100957)2.72315108
21Clubbing of toes (HP:0100760)2.67919779
22Abnormality of the preputium (HP:0100587)2.67186542
23Acute myeloid leukemia (HP:0004808)2.65224313
24Abnormality of the carotid arteries (HP:0005344)2.61841224
25Increased nuchal translucency (HP:0010880)2.61157648
26Short 4th metacarpal (HP:0010044)2.59413983
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59413983
28Small intestinal stenosis (HP:0012848)2.56414987
29Duodenal stenosis (HP:0100867)2.56414987
30Medulloblastoma (HP:0002885)2.53039942
31Absent frontal sinuses (HP:0002688)2.52446128
32Impulsivity (HP:0100710)2.51874540
33Bile duct proliferation (HP:0001408)2.46559860
34Abnormal biliary tract physiology (HP:0012439)2.46559860
35Abnormality of T cell number (HP:0011839)2.43570041
36Heterotopia (HP:0002282)2.43066469
37Medial flaring of the eyebrow (HP:0010747)2.41370210
38Intestinal atresia (HP:0011100)2.38845011
39Congenital stationary night blindness (HP:0007642)2.34542064
40T lymphocytopenia (HP:0005403)2.32923638
41Cystic liver disease (HP:0006706)2.31599904
42Colon cancer (HP:0003003)2.31020254
43Tubular atrophy (HP:0000092)2.29994490
44Renal cortical cysts (HP:0000803)2.26756666
45Septo-optic dysplasia (HP:0100842)2.25289407
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.25036556
47Abnormality of DNA repair (HP:0003254)2.24935507
48Nephroblastoma (Wilms tumor) (HP:0002667)2.24845629
49Birth length less than 3rd percentile (HP:0003561)2.24103147
50Prominent nose (HP:0000448)2.22159997
51Abnormality of the pons (HP:0007361)2.20337625
52Aplasia/Hypoplasia of the patella (HP:0006498)2.19629535
53* Sloping forehead (HP:0000340)2.18330595
54Stomach cancer (HP:0012126)2.18030145
55Anencephaly (HP:0002323)2.15369022
56Deep philtrum (HP:0002002)2.13909370
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.13693241
58Type II lissencephaly (HP:0007260)2.13240706
59Recurrent viral infections (HP:0004429)2.13116453
60Sclerocornea (HP:0000647)2.12459668
61Hypoplasia of the pons (HP:0012110)2.12451768
62Bone marrow hypocellularity (HP:0005528)2.11853797
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10947830
64Optic nerve hypoplasia (HP:0000609)2.10837302
65Selective tooth agenesis (HP:0001592)2.10757146
66Embryonal renal neoplasm (HP:0011794)2.10167792
67Acute lymphatic leukemia (HP:0006721)2.09820652
68Abnormality of the duodenum (HP:0002246)2.09718309
69Papillary thyroid carcinoma (HP:0002895)2.09420685
70Truncal obesity (HP:0001956)2.07594314
71Abnormal respiratory epithelium morphology (HP:0012253)2.06929136
72Abnormal respiratory motile cilium morphology (HP:0005938)2.06929136
73Supernumerary spleens (HP:0009799)2.05529993
74Hyperventilation (HP:0002883)2.04206182
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00405082
76Postaxial foot polydactyly (HP:0001830)1.99538269
77Attenuation of retinal blood vessels (HP:0007843)1.98922048
78Oligodactyly (hands) (HP:0001180)1.98802013
79Cafe-au-lait spot (HP:0000957)1.98601198
80High pitched voice (HP:0001620)1.97750126
81Astigmatism (HP:0000483)1.97618885
82Triphalangeal thumb (HP:0001199)1.97075249
83Progressive inability to walk (HP:0002505)1.95407321
84Small hand (HP:0200055)1.95020783
85Rhabdomyosarcoma (HP:0002859)1.92723404
86Recurrent fungal infections (HP:0002841)1.92638529
87Aplasia/Hypoplasia of the sternum (HP:0006714)1.91808679
88Hypoplastic iliac wings (HP:0002866)1.91563742
89Severe combined immunodeficiency (HP:0004430)1.89457838
90Pendular nystagmus (HP:0012043)1.89327708
91Congenital hepatic fibrosis (HP:0002612)1.89148904
92Dandy-Walker malformation (HP:0001305)1.88497879
93Narrow palate (HP:0000189)1.86830140
94Skull defect (HP:0001362)1.86552849
95Absent radius (HP:0003974)1.86132505
96Lip pit (HP:0100267)1.85234039
97Cerebellar dysplasia (HP:0007033)1.85000075
98Aplastic anemia (HP:0001915)1.84972252
99Absent thumb (HP:0009777)1.84235082
100Anal stenosis (HP:0002025)1.84167612
101Gastrointestinal atresia (HP:0002589)1.84118479
102Dislocated radial head (HP:0003083)1.84093131
103Autoimmune thrombocytopenia (HP:0001973)1.83831038
104Obsessive-compulsive behavior (HP:0000722)1.83795243
105Cutis marmorata (HP:0000965)1.83137178
106Absent forearm bone (HP:0003953)1.83055833
107Aplasia involving forearm bones (HP:0009822)1.83055833
108Abnormal respiratory motile cilium physiology (HP:0012261)1.82835983
109Male pseudohermaphroditism (HP:0000037)1.82400085
110Sandal gap (HP:0001852)1.81965543
111Holoprosencephaly (HP:0001360)1.81550840
112IgG deficiency (HP:0004315)1.81251137
113Congenital primary aphakia (HP:0007707)1.79988076
114Syringomyelia (HP:0003396)1.78583052
115Spinal cord lesions (HP:0100561)1.78583052
116Abnormality of the radial head (HP:0003995)1.78162299
117Leukopenia (HP:0001882)1.77635517
118Abnormal number of incisors (HP:0011064)1.75676673
119Abnormal ciliary motility (HP:0012262)1.75398608
120Hypochromic microcytic anemia (HP:0004840)1.74350816
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.74287277
122Absent/shortened dynein arms (HP:0200106)1.74287277
123Arteriovenous malformation (HP:0100026)1.74148239
124Combined immunodeficiency (HP:0005387)1.74045360
125Polydipsia (HP:0001959)1.73537501
126Abnormal drinking behavior (HP:0030082)1.73537501
127Patellar aplasia (HP:0006443)1.73189218
128Broad palm (HP:0001169)1.72675671
129Preaxial hand polydactyly (HP:0001177)1.72208574
130Furrowed tongue (HP:0000221)1.72063282
131Mediastinal lymphadenopathy (HP:0100721)1.72055156
132Aqueductal stenosis (HP:0002410)1.71458255
133Supernumerary ribs (HP:0005815)1.69326774
134Congenital, generalized hypertrichosis (HP:0004540)1.69106315
135Neoplasm of the oral cavity (HP:0100649)1.68362425
136Oligohydramnios (HP:0001562)1.68289784
137Anophthalmia (HP:0000528)1.67748282
138Gait imbalance (HP:0002141)1.67524467
139Abnormality of the peritoneum (HP:0002585)1.67396420
140Renovascular hypertension (HP:0100817)1.67052330
141Panhypogammaglobulinemia (HP:0003139)1.66309927
142Recurrent bronchitis (HP:0002837)1.66209235
143Trigonocephaly (HP:0000243)1.65937668
144Low anterior hairline (HP:0000294)1.65575281
145Duplicated collecting system (HP:0000081)1.65392207
146Cellulitis (HP:0100658)1.65124291
147Esophageal atresia (HP:0002032)1.64939551
148Amaurosis fugax (HP:0100576)1.64914805
149Abnormality of the renal collecting system (HP:0004742)1.64600656
150Renal duplication (HP:0000075)1.64219233
151Lymphoma (HP:0002665)1.64207509
152Short thumb (HP:0009778)1.63542401
153Oculomotor apraxia (HP:0000657)1.63267692
154Prostate neoplasm (HP:0100787)1.61863804
155Inability to walk (HP:0002540)1.61851813
156Thyroiditis (HP:0100646)1.61768872
157Thrombocytosis (HP:0001894)1.60531192
158Abnormality of T cells (HP:0002843)1.60090829
159Abnormal lung lobation (HP:0002101)1.59617539
160Abnormality of the nasal septum (HP:0000419)1.58737416
161Limited elbow extension (HP:0001377)1.57188133
162Long clavicles (HP:0000890)1.56424935
163Abnormality of chromosome segregation (HP:0002916)1.55358527
164Deviation of the thumb (HP:0009603)1.55120692
165Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.55084849
166Nephronophthisis (HP:0000090)1.54822325
167Neoplasm of striated muscle (HP:0009728)1.54383815
168Abnormality of the 4th metacarpal (HP:0010012)1.54331155
169Basal cell carcinoma (HP:0002671)1.53811491
170Hypochromic anemia (HP:0001931)1.52930783
171Tracheoesophageal fistula (HP:0002575)1.52416640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.52068746
2CDK124.29532304
3NEK23.38171939
4FRK3.08364434
5PNCK2.81144979
6PLK42.77393029
7BMPR1B2.63111963
8WEE12.50796146
9TNIK2.35952879
10LATS12.08146094
11BRD42.07718507
12MAP3K102.07454774
13WNK32.02832091
14STK102.00716472
15TTK1.91339124
16STK41.89877407
17MAP4K11.86513886
18ATR1.82131492
19MAP3K141.74209041
20MKNK11.69960862
21ADRBK21.68966825
22TRIM281.67930341
23TSSK61.65666642
24CHEK21.64736077
25STK31.62701372
26IRAK11.61795821
27PLK11.58854639
28MKNK21.56432094
29SIK21.52958814
30CDK61.51742003
31ZAK1.48839773
32SRPK11.47246404
33MST41.43897148
34CDK41.43458343
35NUAK11.41699391
36BUB11.39238199
37MARK31.38329972
38NEK11.35461056
39AURKB1.34830235
40CHEK11.34302688
41VRK11.32892620
42CASK1.32880704
43ATM1.31214753
44MAP3K41.31144798
45IRAK41.30085786
46BRSK21.27774799
47CCNB11.25857244
48TXK1.23816425
49CDK71.23764907
50JAK31.23623847
51PLK31.22369982
52PKN21.21540735
53YES11.15504722
54EIF2AK11.14896876
55PIM11.10638103
56EIF2AK31.08634625
57BCR1.04065089
58CHUK1.03405580
59WNK41.02257405
60MAP3K81.01851461
61MAPK131.01014087
62SIK31.00229615
63MELK0.99718068
64RPS6KA40.99650282
65EPHA30.97931382
66TGFBR10.97568006
67EEF2K0.96655818
68CDK90.94905883
69FGFR30.93439854
70TAOK30.92519550
71INSRR0.91770044
72EIF2AK20.88440213
73CDK20.87667811
74MAPK150.86436171
75TEC0.85674298
76MAP4K20.83162574
77DYRK20.82083580
78PASK0.81128839
79ACVR1B0.79411239
80GRK10.79155648
81PLK20.78464995
82CAMK1D0.76896811
83CDK10.75236171
84CDK30.74210545
85TAF10.74111017
86TYK20.73320472
87PBK0.73112655
88SGK20.72843209
89MAP2K30.72589508
90MTOR0.71873653
91DYRK30.70121454
92BRSK10.69274410
93BTK0.68067793
94MAP3K130.67853722
95TLK10.67215461
96KIT0.65575934
97SGK30.65456892
98VRK20.63203734
99ERBB30.63110163
100CAMK1G0.62758504
101JAK10.61022225
102IKBKB0.60562068
103STK390.58914977
104IKBKE0.58372738
105ITK0.57158130
106CLK10.56924805
107GRK60.54384021
108RPS6KB20.54227050
109AKT10.53223272
110MAPK140.52714718
111HCK0.51579114
112CSK0.50724057
113PTK2B0.50062460
114LCK0.49588608
115PDGFRB0.48990638
116STK38L0.48924708
117CAMKK20.47190197
118ADRBK10.47023953
119TGFBR20.46847067
120DMPK0.46089756
121CSNK1D0.44256400
122PRKCQ0.43988885
123CSF1R0.43672599
124PRKDC0.42785279
125RPS6KA50.42598482
126NME10.42059837
127PINK10.41960847
128NLK0.41959681
129SYK0.41822555
130OXSR10.41438789
131LYN0.41245227
132ALK0.38919961
133ZAP700.38753607
134MAPK100.38615249
135PRKCG0.38297882
136GSK3B0.37761731
137MAPK10.37033043
138CDK80.37023307
139RIPK10.36688141
140TRPM70.36472895
141ERBB20.34746610
142PKN10.32117064
143FGFR20.31349098
144FGFR10.31335217
145CSNK2A10.30281475
146MUSK0.29454311
147PAK30.29154427

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.04373638
2Fanconi anemia pathway_Homo sapiens_hsa034602.92628576
3Mismatch repair_Homo sapiens_hsa034302.82470933
4Cell cycle_Homo sapiens_hsa041102.78738236
5Homologous recombination_Homo sapiens_hsa034402.64052859
6RNA polymerase_Homo sapiens_hsa030202.38353384
7Non-homologous end-joining_Homo sapiens_hsa034502.35852302
8One carbon pool by folate_Homo sapiens_hsa006702.20618726
9Base excision repair_Homo sapiens_hsa034102.13079575
10Protein export_Homo sapiens_hsa030602.10388656
11Phototransduction_Homo sapiens_hsa047441.97778218
12RNA transport_Homo sapiens_hsa030131.89944772
13RNA degradation_Homo sapiens_hsa030181.86352950
14mRNA surveillance pathway_Homo sapiens_hsa030151.78382119
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77400352
16Spliceosome_Homo sapiens_hsa030401.75166697
17p53 signaling pathway_Homo sapiens_hsa041151.74203431
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.73235377
19Basal transcription factors_Homo sapiens_hsa030221.72660582
20Systemic lupus erythematosus_Homo sapiens_hsa053221.72369309
21Herpes simplex infection_Homo sapiens_hsa051681.69957845
22Nucleotide excision repair_Homo sapiens_hsa034201.66560680
23Nitrogen metabolism_Homo sapiens_hsa009101.61808183
24Primary immunodeficiency_Homo sapiens_hsa053401.56295595
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52225271
26MicroRNAs in cancer_Homo sapiens_hsa052061.49300325
27Measles_Homo sapiens_hsa051621.47803772
28Viral carcinogenesis_Homo sapiens_hsa052031.47333100
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45437019
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44440771
31Small cell lung cancer_Homo sapiens_hsa052221.41333149
32Lysine degradation_Homo sapiens_hsa003101.39875489
33Proteasome_Homo sapiens_hsa030501.38340445
34B cell receptor signaling pathway_Homo sapiens_hsa046621.34724716
35Ribosome_Homo sapiens_hsa030101.29100580
36Chronic myeloid leukemia_Homo sapiens_hsa052201.28980530
37Butanoate metabolism_Homo sapiens_hsa006501.28693543
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27668840
39Linoleic acid metabolism_Homo sapiens_hsa005911.26645566
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25955555
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25321370
42Hepatitis B_Homo sapiens_hsa051611.23846369
43HTLV-I infection_Homo sapiens_hsa051661.22691528
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22108895
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19135129
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18661325
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17257722
48Antigen processing and presentation_Homo sapiens_hsa046121.15463000
49Epstein-Barr virus infection_Homo sapiens_hsa051691.13763133
50Oxidative phosphorylation_Homo sapiens_hsa001901.13407787
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12804347
52Parkinsons disease_Homo sapiens_hsa050121.11512459
53Leishmaniasis_Homo sapiens_hsa051401.10047727
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09911238
55T cell receptor signaling pathway_Homo sapiens_hsa046601.09412627
56Hematopoietic cell lineage_Homo sapiens_hsa046401.06069256
57Osteoclast differentiation_Homo sapiens_hsa043801.05328135
58Influenza A_Homo sapiens_hsa051641.04612226
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.01718798
60Pancreatic cancer_Homo sapiens_hsa052120.97378228
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96863577
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96266404
63Huntingtons disease_Homo sapiens_hsa050160.95834618
64TNF signaling pathway_Homo sapiens_hsa046680.95638456
65Apoptosis_Homo sapiens_hsa042100.94070744
66Oocyte meiosis_Homo sapiens_hsa041140.93641734
67Toxoplasmosis_Homo sapiens_hsa051450.93347307
68Olfactory transduction_Homo sapiens_hsa047400.90923507
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89376919
70Prostate cancer_Homo sapiens_hsa052150.89354189
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.89311077
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88916321
73Colorectal cancer_Homo sapiens_hsa052100.87440237
74Allograft rejection_Homo sapiens_hsa053300.87226718
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86562415
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86220499
77Propanoate metabolism_Homo sapiens_hsa006400.84125954
78Regulation of autophagy_Homo sapiens_hsa041400.82215433
79Notch signaling pathway_Homo sapiens_hsa043300.80663953
80Shigellosis_Homo sapiens_hsa051310.79096800
81Acute myeloid leukemia_Homo sapiens_hsa052210.78691581
82Viral myocarditis_Homo sapiens_hsa054160.78651318
83Pyrimidine metabolism_Homo sapiens_hsa002400.78398214
84Ether lipid metabolism_Homo sapiens_hsa005650.78174009
85Adherens junction_Homo sapiens_hsa045200.77990535
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.77823406
87Non-small cell lung cancer_Homo sapiens_hsa052230.74561004
88FoxO signaling pathway_Homo sapiens_hsa040680.73675179
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.71570018
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71566575
91Taste transduction_Homo sapiens_hsa047420.71249814
92mTOR signaling pathway_Homo sapiens_hsa041500.70781814
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70660281
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68847499
95Chemokine signaling pathway_Homo sapiens_hsa040620.66720830
96Asthma_Homo sapiens_hsa053100.66640591
97Alcoholism_Homo sapiens_hsa050340.66425157
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65969146
99Graft-versus-host disease_Homo sapiens_hsa053320.65789157
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65770324
101TGF-beta signaling pathway_Homo sapiens_hsa043500.65253757
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65010465
103Selenocompound metabolism_Homo sapiens_hsa004500.63966980
104Autoimmune thyroid disease_Homo sapiens_hsa053200.63722085
105Hedgehog signaling pathway_Homo sapiens_hsa043400.63300646
106Pathways in cancer_Homo sapiens_hsa052000.63074191
107Legionellosis_Homo sapiens_hsa051340.61450467
108Prolactin signaling pathway_Homo sapiens_hsa049170.60534003
109Tryptophan metabolism_Homo sapiens_hsa003800.60464559
110Platelet activation_Homo sapiens_hsa046110.58919255
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57996441
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.57995763
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57396276
114Steroid biosynthesis_Homo sapiens_hsa001000.55827148
115Nicotine addiction_Homo sapiens_hsa050330.55754179
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54865055
117Proteoglycans in cancer_Homo sapiens_hsa052050.54544346
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.52197567
119Caffeine metabolism_Homo sapiens_hsa002320.51911415
120Tuberculosis_Homo sapiens_hsa051520.51483396
121Endometrial cancer_Homo sapiens_hsa052130.51040118
122Basal cell carcinoma_Homo sapiens_hsa052170.50463247
123Inositol phosphate metabolism_Homo sapiens_hsa005620.49685907
124Dorso-ventral axis formation_Homo sapiens_hsa043200.49105604
125Type I diabetes mellitus_Homo sapiens_hsa049400.48487207
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47820151
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47442792
128Malaria_Homo sapiens_hsa051440.43396989
129Peroxisome_Homo sapiens_hsa041460.42875975
130Hepatitis C_Homo sapiens_hsa051600.42696469
131Purine metabolism_Homo sapiens_hsa002300.42228759
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42100260
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40772417
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40642958
135Melanoma_Homo sapiens_hsa052180.40631078
136Focal adhesion_Homo sapiens_hsa045100.40519316
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38865129
138MAPK signaling pathway_Homo sapiens_hsa040100.38563855
139Serotonergic synapse_Homo sapiens_hsa047260.33600333
140Alzheimers disease_Homo sapiens_hsa050100.33480657
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32565160
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30047293
143Morphine addiction_Homo sapiens_hsa050320.28427444
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27271334
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.24033212
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22795335
147Arachidonic acid metabolism_Homo sapiens_hsa005900.22279457
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21550018

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »