CEP152

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* centriole replication (GO:0007099)5.06543997
2microtubule polymerization or depolymerization (GO:0031109)4.95875799
3DNA unwinding involved in DNA replication (GO:0006268)4.85557981
4protein localization to kinetochore (GO:0034501)4.60989371
5sperm motility (GO:0030317)4.54558752
6nuclear pore complex assembly (GO:0051292)4.50630544
7nuclear pore organization (GO:0006999)4.39627480
8synapsis (GO:0007129)4.25563198
9DNA strand elongation involved in DNA replication (GO:0006271)4.21912656
10DNA double-strand break processing (GO:0000729)4.09414573
11resolution of meiotic recombination intermediates (GO:0000712)4.08187309
12mitotic chromosome condensation (GO:0007076)4.07267037
13DNA strand elongation (GO:0022616)4.03832434
14DNA replication initiation (GO:0006270)4.02145138
15protein localization to chromosome, centromeric region (GO:0071459)3.97825247
16telomere maintenance via semi-conservative replication (GO:0032201)3.97669982
17spermatid nucleus differentiation (GO:0007289)3.97368550
18mitotic recombination (GO:0006312)3.93967215
19kinetochore organization (GO:0051383)3.93879865
20sister chromatid segregation (GO:0000819)3.91024846
21* centriole assembly (GO:0098534)3.90497112
22acrosome reaction (GO:0007340)3.88502569
23double-strand break repair via homologous recombination (GO:0000724)3.87159128
24telomere maintenance via recombination (GO:0000722)3.86907352
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86743930
26recombinational repair (GO:0000725)3.86667090
27rRNA methylation (GO:0031167)3.82582079
28mitotic sister chromatid segregation (GO:0000070)3.75377404
29DNA geometric change (GO:0032392)3.65490294
30DNA duplex unwinding (GO:0032508)3.62765362
31mitotic G2/M transition checkpoint (GO:0044818)3.61893669
32mitotic sister chromatid cohesion (GO:0007064)3.61290769
33mitotic nuclear envelope disassembly (GO:0007077)3.57404184
34regulation of centriole replication (GO:0046599)3.57123206
35pore complex assembly (GO:0046931)3.55273400
36DNA replication checkpoint (GO:0000076)3.54248603
37rRNA modification (GO:0000154)3.51107895
38DNA replication-dependent nucleosome assembly (GO:0006335)3.49960327
39DNA replication-dependent nucleosome organization (GO:0034723)3.49960327
40DNA ligation (GO:0006266)3.49107478
41CENP-A containing nucleosome assembly (GO:0034080)3.48417972
42fusion of sperm to egg plasma membrane (GO:0007342)3.48078675
43* centrosome organization (GO:0051297)3.47723630
44spermatid development (GO:0007286)3.47498669
45chromatin remodeling at centromere (GO:0031055)3.47223038
46sperm-egg recognition (GO:0035036)3.43164723
47single strand break repair (GO:0000012)3.42447571
48dosage compensation (GO:0007549)3.39532231
49attachment of spindle microtubules to kinetochore (GO:0008608)3.38903084
50DNA replication-independent nucleosome assembly (GO:0006336)3.38773456
51DNA replication-independent nucleosome organization (GO:0034724)3.38773456
52regulation of DNA endoreduplication (GO:0032875)3.38127428
53folic acid-containing compound biosynthetic process (GO:0009396)3.37053528
54regulation of histone H3-K9 methylation (GO:0051570)3.35478899
55sister chromatid cohesion (GO:0007062)3.35315417
56translesion synthesis (GO:0019985)3.29445163
57membrane disassembly (GO:0030397)3.27742150
58nuclear envelope disassembly (GO:0051081)3.27742150
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26095593
60mitotic metaphase plate congression (GO:0007080)3.24468437
61non-recombinational repair (GO:0000726)3.23851142
62double-strand break repair via nonhomologous end joining (GO:0006303)3.23851142
63meiotic chromosome segregation (GO:0045132)3.23256754
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.21893944
65chromosome organization (GO:0051276)3.20791401
66binding of sperm to zona pellucida (GO:0007339)3.19774872
67telomere maintenance via telomere lengthening (GO:0010833)3.19731826
68response to pheromone (GO:0019236)3.19629607
69* microtubule organizing center organization (GO:0031023)3.19174426
70DNA topological change (GO:0006265)3.18182915
71chromatin assembly or disassembly (GO:0006333)3.15844363
72double-strand break repair (GO:0006302)3.15375383
73chromosome organization involved in meiosis (GO:0070192)3.12357378
74DNA conformation change (GO:0071103)3.12079144
75regulation of sister chromatid segregation (GO:0033045)3.10833497
76regulation of mitotic sister chromatid separation (GO:0010965)3.10833497
77regulation of mitotic sister chromatid segregation (GO:0033047)3.10833497
78kinetochore assembly (GO:0051382)3.10685055
79negative regulation of chromosome segregation (GO:0051985)3.07061671
80regulation of spindle organization (GO:0090224)3.05658676
81multicellular organism reproduction (GO:0032504)3.03689649
82IMP biosynthetic process (GO:0006188)3.01654112
83meiotic cell cycle process (GO:1903046)3.01341431
84telomere maintenance (GO:0000723)3.01187788
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00637748
86positive regulation of chromosome segregation (GO:0051984)2.99793131
87metaphase plate congression (GO:0051310)2.99531782
88telomere organization (GO:0032200)2.98749419
89negative regulation of histone methylation (GO:0031061)2.96612273
90regulation of centrosome cycle (GO:0046605)2.94327410
91natural killer cell mediated immunity (GO:0002228)2.94036369
92natural killer cell mediated cytotoxicity (GO:0042267)2.94036369
93positive regulation of mitotic sister chromatid separation (GO:1901970)2.92561248
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92561248
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92561248
96positive regulation of gamma-delta T cell activation (GO:0046645)2.91755401
97DNA synthesis involved in DNA repair (GO:0000731)2.90961984
98establishment of chromosome localization (GO:0051303)2.90673477
99chromosome condensation (GO:0030261)2.88925658
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87625256
101histone exchange (GO:0043486)2.87521410
102chromatin assembly (GO:0031497)2.83524465
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83461264
104protein localization to chromosome (GO:0034502)2.81664910
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.79940814
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79940814
107regulation of mitotic spindle organization (GO:0060236)2.77758506
108chromosome segregation (GO:0007059)2.75412233
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.72698834
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72263090
111histone mRNA catabolic process (GO:0071044)2.72075341
112mismatch repair (GO:0006298)2.71575000
113positive regulation of B cell differentiation (GO:0045579)2.71392064
114ATP-dependent chromatin remodeling (GO:0043044)2.71348232
115protein K6-linked ubiquitination (GO:0085020)2.70958831
116DNA packaging (GO:0006323)2.70707835
117regulation of centrosome duplication (GO:0010824)2.70496927
118regulation of sister chromatid cohesion (GO:0007063)2.65464455
119IMP metabolic process (GO:0046040)2.64378268
120ribosomal small subunit assembly (GO:0000028)2.64357188
121negative regulation of RNA splicing (GO:0033119)2.61324064
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.60166770
123microtubule depolymerization (GO:0007019)2.59753621
124replication fork processing (GO:0031297)2.59217216
125regulation of chromosome segregation (GO:0051983)2.55833055
126postreplication repair (GO:0006301)2.54998923
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.53441941
128pre-miRNA processing (GO:0031054)2.52876668
129regulation of RNA export from nucleus (GO:0046831)2.50585079
130tetrahydrofolate metabolic process (GO:0046653)2.49702198
131hepatocyte apoptotic process (GO:0097284)2.49657026
132nucleobase biosynthetic process (GO:0046112)2.49002178
133DNA strand renaturation (GO:0000733)2.48901926
134snRNA processing (GO:0016180)2.47533709
135regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.46568203
136spindle checkpoint (GO:0031577)2.44463160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.57424120
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.27521985
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.40255781
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34590219
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.57023960
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35384318
7MYC_22102868_ChIP-Seq_BL_Human2.34253557
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.33667700
9AR_21909140_ChIP-Seq_LNCAP_Human2.30265060
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.01674685
11FUS_26573619_Chip-Seq_HEK293_Human2.01083362
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00993363
13E2F7_22180533_ChIP-Seq_HELA_Human11.3237678
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93263846
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90259469
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89433761
17ZNF274_21170338_ChIP-Seq_K562_Hela1.88300810
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88030339
19MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86240840
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86045100
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84972489
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84082422
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83344502
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81784198
25VDR_21846776_ChIP-Seq_THP-1_Human1.81388912
26VDR_22108803_ChIP-Seq_LS180_Human1.70027375
27EWS_26573619_Chip-Seq_HEK293_Human1.67174231
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66950798
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64936078
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.63488850
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62748797
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60675091
33SCL_19346495_ChIP-Seq_HPC-7_Human1.60539341
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60163353
35CIITA_25753668_ChIP-Seq_RAJI_Human1.56245068
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55394292
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54137535
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52560434
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52438437
40MYC_18940864_ChIP-ChIP_HL60_Human1.51556071
41IRF1_19129219_ChIP-ChIP_H3396_Human1.50800135
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50447225
43VDR_23849224_ChIP-Seq_CD4+_Human1.48972719
44FOXP3_21729870_ChIP-Seq_TREG_Human1.44722013
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44249500
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.43016492
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42665713
48XRN2_22483619_ChIP-Seq_HELA_Human1.41404965
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40643537
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38235108
51MYB_26560356_Chip-Seq_TH1_Human1.38197777
52* MYB_26560356_Chip-Seq_TH2_Human1.37834609
53SPI1_23547873_ChIP-Seq_NB4_Human1.36166008
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34682687
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34345668
56MAF_26560356_Chip-Seq_TH1_Human1.34290118
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33941017
58ELK1_19687146_ChIP-ChIP_HELA_Human1.33818685
59* ER_23166858_ChIP-Seq_MCF-7_Human1.33635583
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32795465
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31528468
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28117709
63CBP_20019798_ChIP-Seq_JUKART_Human1.28117709
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27295485
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26980664
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26300538
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26236965
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23664254
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.23465971
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23358181
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.23009580
72TAF15_26573619_Chip-Seq_HEK293_Human1.22834267
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21545027
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20835924
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20052304
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19084029
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19015314
78KDM5A_27292631_Chip-Seq_BREAST_Human1.18203652
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16468428
80DCP1A_22483619_ChIP-Seq_HELA_Human1.16313297
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15629942
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.15512988
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15296026
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.14029038
85UTX_26944678_Chip-Seq_JUKART_Human1.13641732
86TCF7_22412390_ChIP-Seq_EML_Mouse1.13076420
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12404826
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11628195
89VDR_24763502_ChIP-Seq_THP-1_Human1.11584456
90* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10886940
91P300_19829295_ChIP-Seq_ESCs_Human1.07925890
92TTF2_22483619_ChIP-Seq_HELA_Human1.07752571
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06786685
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06622039
95IGF1R_20145208_ChIP-Seq_DFB_Human1.06569184
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.06559107
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05645078
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05525934
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05525934
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05048414
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04896627
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.03762900
103TFEB_21752829_ChIP-Seq_HELA_Human1.02853123
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01986894
105* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01504386
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99460761
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99417885
108NFYB_21822215_ChIP-Seq_K562_Human0.98473346
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97553171
110* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96630356
111RBPJ_21746931_ChIP-Seq_IB4_Human0.96477395
112SALL4_22934838_ChIP-ChIP_CD34+_Human0.96449831
113ETV1_20927104_ChIP-Seq_GIST48_Human0.96258891
114GABP_19822575_ChIP-Seq_HepG2_Human0.96021775
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95736337
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95564451
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.94178074
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93633979
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93219252
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.92164968
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91506519
122PHF8_20622853_ChIP-Seq_HELA_Human0.91462711
123* STAT3_23295773_ChIP-Seq_U87_Human0.91403106
124HNFA_21074721_ChIP-Seq_CACO-2_Human0.90702610
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90695107
126CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90639699
127HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90057554
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89875692
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88964277
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.88706508
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88442761
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88247268
133SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87956584
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87760047
135GATA1_22025678_ChIP-Seq_K562_Human0.87510335
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83590367
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81526605
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81293326
139PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81186780
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80826051
141TCF4_23295773_ChIP-Seq_U87_Human0.80801554
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79431477
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.78520546
144FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78520546
145NFYA_21822215_ChIP-Seq_K562_Human0.78242944
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77933232
147GATA6_21074721_ChIP-Seq_CACO-2_Human0.77921036
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77641568
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77389976
150TBL1_22424771_ChIP-Seq_293T_Human0.77354433
151GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76408578
152POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76311212
153TP53_22573176_ChIP-Seq_HFKS_Human0.75269515
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.74764251
155GATA3_26560356_Chip-Seq_TH1_Human0.73475066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.09744093
2MP0010094_abnormal_chromosome_stability3.97211033
3MP0003693_abnormal_embryo_hatching3.52054325
4MP0008057_abnormal_DNA_replication3.51954041
5MP0003718_maternal_effect3.40392614
6MP0003111_abnormal_nucleus_morphology3.37360768
7MP0003077_abnormal_cell_cycle3.08177366
8MP0002396_abnormal_hematopoietic_system3.03930924
9MP0009697_abnormal_copulation2.78712603
10MP0001929_abnormal_gametogenesis2.66202802
11MP0008058_abnormal_DNA_repair2.58161744
12MP0004957_abnormal_blastocyst_morpholog2.50883605
13MP0010307_abnormal_tumor_latency2.41165546
14MP0003698_abnormal_male_reproductive2.31616331
15MP0001835_abnormal_antigen_presentation2.28203142
16MP0000372_irregular_coat_pigmentation2.27730245
17MP0000569_abnormal_digit_pigmentation2.26696199
18MP0010352_gastrointestinal_tract_polyps2.26675364
19MP0008007_abnormal_cellular_replicative2.25882984
20MP0006292_abnormal_olfactory_placode2.19688758
21MP0008877_abnormal_DNA_methylation2.12525206
22MP0004808_abnormal_hematopoietic_stem2.12519329
23MP0001800_abnormal_humoral_immune1.91969845
24MP0003763_abnormal_thymus_physiology1.91909806
25MP0002398_abnormal_bone_marrow1.85954078
26MP0004147_increased_porphyrin_level1.82038566
27MP0000350_abnormal_cell_proliferation1.79091687
28MP0005076_abnormal_cell_differentiation1.75906221
29MP0000685_abnormal_immune_system1.75638782
30MP0000490_abnormal_crypts_of1.74623850
31MP0003436_decreased_susceptibility_to1.74254146
32MP0005397_hematopoietic_system_phenotyp1.71786572
33MP0001545_abnormal_hematopoietic_system1.71786572
34MP0009278_abnormal_bone_marrow1.67382633
35MP0000703_abnormal_thymus_morphology1.66024429
36MP0003646_muscle_fatigue1.65005917
37MP0005377_hearing/vestibular/ear_phenot1.61630950
38MP0003878_abnormal_ear_physiology1.61630950
39MP0002166_altered_tumor_susceptibility1.60838067
40MP0005671_abnormal_response_to1.60107849
41MP0001145_abnormal_male_reproductive1.59820777
42MP0002452_abnormal_antigen_presenting1.59364947
43MP0002722_abnormal_immune_system1.58443973
44MP0001730_embryonic_growth_arrest1.58246796
45MP0000689_abnormal_spleen_morphology1.57772051
46MP0000653_abnormal_sex_gland1.55971110
47MP0002420_abnormal_adaptive_immunity1.49810046
48MP0001819_abnormal_immune_cell1.48542079
49MP0003136_yellow_coat_color1.46669958
50MP0002723_abnormal_immune_serum1.43573882
51MP0002161_abnormal_fertility/fecundity1.41798479
52MP0000716_abnormal_immune_system1.40312094
53MP0002019_abnormal_tumor_incidence1.40156881
54MP0002429_abnormal_blood_cell1.37694743
55MP0008995_early_reproductive_senescence1.36812024
56MP0002405_respiratory_system_inflammati1.36326102
57MP0005000_abnormal_immune_tolerance1.34616976
58MP0009333_abnormal_splenocyte_physiolog1.34009809
59MP0008932_abnormal_embryonic_tissue1.33954529
60MP0001790_abnormal_immune_system1.32854090
61MP0005387_immune_system_phenotype1.32854090
62MP0002006_tumorigenesis1.32301016
63MP0005174_abnormal_tail_pigmentation1.31465652
64MP0003787_abnormal_imprinting1.29304184
65MP0000313_abnormal_cell_death1.27882168
66MP0001672_abnormal_embryogenesis/_devel1.26924105
67MP0005380_embryogenesis_phenotype1.26924105
68MP0005464_abnormal_platelet_physiology1.23726233
69MP0002148_abnormal_hypersensitivity_rea1.21988879
70MP0003705_abnormal_hypodermis_morpholog1.21734635
71MP0005395_other_phenotype1.20182208
72MP0010155_abnormal_intestine_physiology1.19090445
73MP0002419_abnormal_innate_immunity1.18407409
74MP0005025_abnormal_response_to1.18272982
75MP0003566_abnormal_cell_adhesion1.18187070
76MP0006072_abnormal_retinal_apoptosis1.18055825
77MP0001915_intracranial_hemorrhage1.18020030
78MP0003786_premature_aging1.17932902
79MP0005670_abnormal_white_adipose1.17886949
80MP0003984_embryonic_growth_retardation1.16737277
81MP0001853_heart_inflammation1.15667667
82MP0002088_abnormal_embryonic_growth/wei1.15590092
83MP0006054_spinal_hemorrhage1.14704524
84MP0002086_abnormal_extraembryonic_tissu1.14193621
85MP0004197_abnormal_fetal_growth/weight/1.13652608
86MP0001697_abnormal_embryo_size1.13069684
87MP0003300_gastrointestinal_ulcer1.10979476
88MP0009785_altered_susceptibility_to1.10170980
89MP0005551_abnormal_eye_electrophysiolog1.08894962
90MP0002080_prenatal_lethality1.07727580
91MP0002938_white_spotting1.07707278
92MP0000371_diluted_coat_color1.06038862
93MP0003121_genomic_imprinting1.05669592
94MP0001119_abnormal_female_reproductive1.04631673
95MP0002234_abnormal_pharynx_morphology1.04487466
96MP0005253_abnormal_eye_physiology1.04428794
97MP0005408_hypopigmentation1.04166629
98MP0001873_stomach_inflammation1.02725008
99MP0001485_abnormal_pinna_reflex1.01762212
100MP0002102_abnormal_ear_morphology0.99760199
101MP0005171_absent_coat_pigmentation0.98365889
102MP0000015_abnormal_ear_pigmentation0.98121225
103MP0002160_abnormal_reproductive_system0.97188062
104MP0000427_abnormal_hair_cycle0.96174253
105MP0003950_abnormal_plasma_membrane0.95992689
106MP0005023_abnormal_wound_healing0.95614167
107MP0002085_abnormal_embryonic_tissue0.94401847
108MP0006035_abnormal_mitochondrial_morpho0.93579330
109MP0003699_abnormal_female_reproductive0.92238880
110MP0002132_abnormal_respiratory_system0.91915764
111MP0000858_altered_metastatic_potential0.91543737
112MP0005083_abnormal_biliary_tract0.91049308
113MP0005379_endocrine/exocrine_gland_phen0.89853136
114MP0004947_skin_inflammation0.89737060
115MP0001845_abnormal_inflammatory_respons0.88148277
116MP0003937_abnormal_limbs/digits/tail_de0.87384627
117MP0002095_abnormal_skin_pigmentation0.85844569
118MP0008789_abnormal_olfactory_epithelium0.85408101
119MP0002084_abnormal_developmental_patter0.84384178
120MP0004264_abnormal_extraembryonic_tissu0.84269424
121MP0003303_peritoneal_inflammation0.82109541
122MP0002163_abnormal_gland_morphology0.82057431
123MP0006036_abnormal_mitochondrial_physio0.81658333
124MP0003567_abnormal_fetal_cardiomyocyte0.81288086
125MP0003172_abnormal_lysosome_physiology0.79287399
126MP0003448_altered_tumor_morphology0.77677628
127MP0000358_abnormal_cell_content/0.76779928
128MP0005621_abnormal_cell_physiology0.76260764
129MP0005389_reproductive_system_phenotype0.75198859
130MP0002075_abnormal_coat/hair_pigmentati0.73678211
131MP0002928_abnormal_bile_duct0.72252841
132MP0005075_abnormal_melanosome_morpholog0.71869311
133MP0003656_abnormal_erythrocyte_physiolo0.71307188
134MP0002009_preneoplasia0.71237363
135MP0001286_abnormal_eye_development0.70653306
136MP0003890_abnormal_embryonic-extraembry0.69527091
137MP0003123_paternal_imprinting0.68893178
138MP0005391_vision/eye_phenotype0.68825455
139MP0001293_anophthalmia0.68502364
140MP0009053_abnormal_anal_canal0.67729057
141MP0000733_abnormal_muscle_development0.66562173
142MP0005384_cellular_phenotype0.65757009
143MP0000465_gastrointestinal_hemorrhage0.65493006
144MP0003828_pulmonary_edema0.64691689
145MP0000631_abnormal_neuroendocrine_gland0.64670158
146MP0002210_abnormal_sex_determination0.64074098
147MP0002837_dystrophic_cardiac_calcinosis0.62591375
148MP0004742_abnormal_vestibular_system0.61947010
149MP0009115_abnormal_fat_cell0.58161622
150MP0001324_abnormal_eye_pigmentation0.55457208
151MP0003943_abnormal_hepatobiliary_system0.54880046
152MP0005266_abnormal_metabolism0.54147802
153MP0005647_abnormal_sex_gland0.53834968
154MP0005310_abnormal_salivary_gland0.52116396
155MP0000678_abnormal_parathyroid_gland0.51624464

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.68413508
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26224987
3Reticulocytopenia (HP:0001896)3.46397414
4Abnormality of chromosome stability (HP:0003220)3.32446405
5Abnormality of the fingertips (HP:0001211)3.28162972
6Chronic hepatic failure (HP:0100626)3.20851447
7Ectopic kidney (HP:0000086)3.10111843
8Tubulointerstitial nephritis (HP:0001970)2.97113635
9IgM deficiency (HP:0002850)2.95770930
10Recurrent viral infections (HP:0004429)2.94678003
11Severe visual impairment (HP:0001141)2.90847020
12Volvulus (HP:0002580)2.85105213
13Birth length less than 3rd percentile (HP:0003561)2.80088567
14Myelodysplasia (HP:0002863)2.75272980
15Prominent nose (HP:0000448)2.63228859
16Recurrent abscess formation (HP:0002722)2.62352650
17Nephronophthisis (HP:0000090)2.62197757
18Embryonal renal neoplasm (HP:0011794)2.59019862
19Abnormality of the renal collecting system (HP:0004742)2.57933202
20Attenuation of retinal blood vessels (HP:0007843)2.56673191
21Pancreatic fibrosis (HP:0100732)2.55361742
22Increased nuchal translucency (HP:0010880)2.51630375
23Cellulitis (HP:0100658)2.50430748
24High pitched voice (HP:0001620)2.49999861
25Pancreatic cysts (HP:0001737)2.49037535
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.47972651
27Duplicated collecting system (HP:0000081)2.45681755
28Agnosia (HP:0010524)2.44008473
29Recurrent bacterial skin infections (HP:0005406)2.43825716
30Meckel diverticulum (HP:0002245)2.41119673
31Abnormality of the preputium (HP:0100587)2.39947568
32Triphalangeal thumb (HP:0001199)2.38645454
33Thrombocytosis (HP:0001894)2.37382785
34Selective tooth agenesis (HP:0001592)2.37380634
35B lymphocytopenia (HP:0010976)2.36491502
36Abnormality of B cell number (HP:0010975)2.36491502
37Medulloblastoma (HP:0002885)2.35272157
38Abnormality of the renal medulla (HP:0100957)2.34031684
39Deviation of the thumb (HP:0009603)2.33030761
40Abnormality of the ileum (HP:0001549)2.30215090
41Proximal placement of thumb (HP:0009623)2.29062171
42T lymphocytopenia (HP:0005403)2.29046013
43Lymphoma (HP:0002665)2.27765365
44* Aplasia/Hypoplasia of the earlobes (HP:0009906)2.21613988
45Bony spicule pigmentary retinopathy (HP:0007737)2.21039328
46Recurrent fungal infections (HP:0002841)2.20978428
47Abnormal lung lobation (HP:0002101)2.20624023
48Thyroiditis (HP:0100646)2.19552334
49Recurrent bronchitis (HP:0002837)2.18846627
50Deep philtrum (HP:0002002)2.18827237
51* Sloping forehead (HP:0000340)2.17928355
52Absent/shortened dynein arms (HP:0200106)2.17859241
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.17859241
54Small intestinal stenosis (HP:0012848)2.16593133
55Duodenal stenosis (HP:0100867)2.16593133
56Arteriovenous malformation (HP:0100026)2.16253469
57Abnormality of T cell number (HP:0011839)2.15807777
58Abnormality of DNA repair (HP:0003254)2.15164544
59Abnormality of cochlea (HP:0000375)2.14140547
60Acute myeloid leukemia (HP:0004808)2.13371708
61Astigmatism (HP:0000483)2.12682682
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11494248
63Short 4th metacarpal (HP:0010044)2.11494248
64Absent radius (HP:0003974)2.10881715
65Leukopenia (HP:0001882)2.09632142
66Abnormal number of incisors (HP:0011064)2.07931157
67Abnormal spermatogenesis (HP:0008669)2.06830058
68Basal cell carcinoma (HP:0002671)2.06808491
69Cafe-au-lait spot (HP:0000957)2.04382530
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03956239
71Abnormality of the carotid arteries (HP:0005344)2.03290021
72Abnormality of the labia minora (HP:0012880)2.00842479
73Ependymoma (HP:0002888)2.00708126
74Panhypogammaglobulinemia (HP:0003139)2.00694214
75Pustule (HP:0200039)2.00393457
76Long eyelashes (HP:0000527)1.99101972
77Oligohydramnios (HP:0001562)1.98592031
78Patellar aplasia (HP:0006443)1.98572493
79Rhabdomyosarcoma (HP:0002859)1.97863189
80Pendular nystagmus (HP:0012043)1.97708945
81Hypoplasia of the pons (HP:0012110)1.97501286
82Bone marrow hypocellularity (HP:0005528)1.97236859
83Amaurosis fugax (HP:0100576)1.97203083
84Glioma (HP:0009733)1.96756037
85Clubbing of toes (HP:0100760)1.96716777
86Absent forearm bone (HP:0003953)1.95553338
87Aplasia involving forearm bones (HP:0009822)1.95553338
88Eczematoid dermatitis (HP:0000976)1.94862940
89Combined immunodeficiency (HP:0005387)1.94592056
90Abnormality of reticulocytes (HP:0004312)1.94209333
91Abnormality of the renal cortex (HP:0011035)1.94161448
92Abnormality of midbrain morphology (HP:0002418)1.92059393
93Molar tooth sign on MRI (HP:0002419)1.92059393
94Abnormal platelet volume (HP:0011876)1.91755356
95Horseshoe kidney (HP:0000085)1.91699310
96* Impulsivity (HP:0100710)1.90989996
97Colitis (HP:0002583)1.90860436
98Abnormality of T cells (HP:0002843)1.90745943
99Short thumb (HP:0009778)1.90626926
100True hermaphroditism (HP:0010459)1.90459487
101Abnormality of pyrimidine metabolism (HP:0004353)1.90425172
102Cutis marmorata (HP:0000965)1.90169690
103Abnormality of the pons (HP:0007361)1.90099768
104Embryonal neoplasm (HP:0002898)1.89753915
105Eosinophilia (HP:0001880)1.88951060
106IgA deficiency (HP:0002720)1.87899038
107Lip pit (HP:0100267)1.86390130
108Absent thumb (HP:0009777)1.85096427
109Truncal obesity (HP:0001956)1.84792402
110Small hand (HP:0200055)1.84477015
111Abnormality of chromosome segregation (HP:0002916)1.83801455
112Oligodactyly (hands) (HP:0001180)1.83378184
113Abnormality of the duodenum (HP:0002246)1.83257797
114Short middle phalanx of the 5th finger (HP:0004220)1.83133453
115Increased density of long bones (HP:0006392)1.81809283
116Autoimmune thrombocytopenia (HP:0001973)1.81035745
117Supernumerary spleens (HP:0009799)1.79961374
118Chronic otitis media (HP:0000389)1.79911716
119Elevated erythrocyte sedimentation rate (HP:0003565)1.79907267
120Aplasia/Hypoplasia of the patella (HP:0006498)1.79027227
121Gastrointestinal inflammation (HP:0004386)1.78960863
122Severe combined immunodeficiency (HP:0004430)1.78832377
123Atresia of the external auditory canal (HP:0000413)1.78389267
124Colon cancer (HP:0003003)1.78170727
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.77581963
126Abnormality of cells of the erythroid lineage (HP:0012130)1.77196392
127Tracheoesophageal fistula (HP:0002575)1.77194786
128Hypoplastic iliac wings (HP:0002866)1.77095355
129Cerebellar dysplasia (HP:0007033)1.76955792
130Osteomyelitis (HP:0002754)1.76251220
131Petechiae (HP:0000967)1.75445956
132Skin tags (HP:0010609)1.73849257
133Skull defect (HP:0001362)1.73732198
134Inflammation of the large intestine (HP:0002037)1.73581704
135Abnormal rod and cone electroretinograms (HP:0008323)1.73340641
136Choanal atresia (HP:0000453)1.73070851
137Poikilocytosis (HP:0004447)1.72827734
138Granulocytopenia (HP:0001913)1.72556697
139Mediastinal lymphadenopathy (HP:0100721)1.72440843
140Nephroblastoma (Wilms tumor) (HP:0002667)1.71719935
141Lymphopenia (HP:0001888)1.71683971
142Abnormal number of erythroid precursors (HP:0012131)1.71123235
143Microtia (HP:0008551)1.70945873
144Increased mean platelet volume (HP:0011877)1.70119412
14511 pairs of ribs (HP:0000878)1.69068427
146Pallor (HP:0000980)1.69059283
147Aganglionic megacolon (HP:0002251)1.67492837
148Neoplasm of the oral cavity (HP:0100649)1.66373857
149Azoospermia (HP:0000027)1.65472654
150Abnormality of the astrocytes (HP:0100707)1.63185301
151Astrocytoma (HP:0009592)1.63185301
152Aplasia/Hypoplasia of the sternum (HP:0006714)1.63169668
153Tubulointerstitial abnormality (HP:0001969)1.62165941
154Hypergonadotropic hypogonadism (HP:0000815)1.62140617
155Neoplasm of striated muscle (HP:0009728)1.60734986
156* Sandal gap (HP:0001852)1.60415131
157Abnormality of macular pigmentation (HP:0008002)1.60414521
158Postaxial foot polydactyly (HP:0001830)1.60176372
159Cone-rod dystrophy (HP:0000548)1.58817701
160Acanthocytosis (HP:0001927)1.57928074
161Holoprosencephaly (HP:0001360)1.57529106
162Abnormal respiratory motile cilium physiology (HP:0012261)1.57528816
163Morphological abnormality of the inner ear (HP:0011390)1.57407316
164Median cleft lip (HP:0000161)1.56637122
165Neoplasm of the adrenal cortex (HP:0100641)1.56510620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.30509073
2CDK123.17440828
3NEK23.06156739
4BRSK22.69506897
5FRK2.41039880
6MAP4K12.33477085
7WEE12.26443391
8BUB12.16519077
9STK102.11860375
10TTK2.05759931
11STK42.00766596
12EEF2K1.99847813
13PLK21.95963581
14MAP3K101.92584622
15BMPR1B1.85605767
16ATR1.84204383
17PNCK1.82928939
18TYK21.81084831
19INSRR1.73526067
20PLK41.73018053
21CDK41.69097054
22RPS6KB21.61473972
23TLK11.55539845
24ERBB31.53301316
25RPS6KA41.53224404
26SRPK11.49481594
27NEK11.47470109
28MKNK11.45674820
29AURKB1.45072360
30ZAK1.44685835
31MAP3K141.43870298
32BRD41.42937551
33STK38L1.41716023
34PBK1.41553686
35CDK61.41383504
36PIM11.40093770
37SIK21.39960844
38MAP4K21.39429067
39BTK1.37718486
40LATS11.36066420
41PLK11.35922124
42CDK71.35324172
43PASK1.34435923
44CAMK1G1.32053431
45PDK21.28722486
46CHEK21.27954117
47TRPM71.25050061
48BRSK11.21931788
49YES11.19589617
50PKN21.19161271
51CSF1R1.18960564
52MAP3K81.18459642
53CHEK11.18184623
54TSSK61.17503822
55NME21.14266922
56JAK31.13941978
57VRK11.10891584
58CLK11.06432427
59ATM1.04997479
60NEK91.03109236
61TAF11.02295713
62KIT1.01264689
63EIF2AK10.97687401
64GRK60.97664861
65TEC0.97345508
66CHUK0.96780283
67DYRK30.95226420
68TXK0.95052437
69HCK0.94381117
70WNK40.93325324
71MARK30.93207003
72PLK30.92396359
73STK30.90574111
74FLT30.90558245
75MELK0.87587419
76ITK0.86019323
77IKBKB0.83673812
78TTN0.83011605
79ZAP700.81885136
80TNIK0.80802579
81TGFBR20.79948903
82IRAK40.79350903
83VRK20.78676153
84WNK30.78657316
85ACVR1B0.78330198
86CDK20.78280676
87TRIM280.75962180
88CDK30.75799692
89STK390.74963256
90EIF2AK30.74289278
91SYK0.74224855
92JAK10.72960628
93NEK60.72603010
94MST40.72329020
95TBK10.70342431
96EIF2AK20.69364987
97LCK0.68686743
98IKBKE0.67709492
99MAP3K40.67634031
100CSK0.66370573
101RPS6KA50.65871928
102NUAK10.65627285
103LRRK20.65432182
104LYN0.64931638
105TGFBR10.64841540
106CDK90.64750536
107PAK40.64314557
108SCYL20.63381531
109BRAF0.63366504
110TAOK30.62699375
111MKNK20.61738618
112MAP2K30.58025227
113CDK80.57993620
114WNK10.57862728
115CDK10.57580534
116CCNB10.56784906
117CAMK1D0.56483059
118MTOR0.56210505
119PTK60.56000884
120MST1R0.55418978
121FGFR30.49673039
122AURKA0.49204453
123BLK0.48759344
124ALK0.48457677
125PRKDC0.47901133
126BMPR20.47346581
127FGFR40.46161969
128NME10.45784819
129MAPKAPK20.45636192
130PIK3CG0.44303818
131MAPKAPK50.42889648
132SIK10.42769270
133MAPK130.39804187
134GSK3B0.38500804
135OXSR10.37264739
136MAPK140.35219372
137CSNK2A10.34713874
138CSNK2A20.34337053
139CSNK1E0.30519973
140ADRBK20.28415203
141PRKAA20.26852954
142PTK2B0.26424477
143MAPK10.24164379
144STK160.23958469
145AKT30.22721619
146AKT10.22360432
147CSNK1D0.20696111

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45431744
2Mismatch repair_Homo sapiens_hsa034303.75790912
3One carbon pool by folate_Homo sapiens_hsa006703.08917767
4Homologous recombination_Homo sapiens_hsa034402.91252383
5Non-homologous end-joining_Homo sapiens_hsa034502.67540240
6Base excision repair_Homo sapiens_hsa034102.67276937
7Cell cycle_Homo sapiens_hsa041102.52464147
8Spliceosome_Homo sapiens_hsa030402.43691037
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39698569
10Fanconi anemia pathway_Homo sapiens_hsa034602.26541811
11Systemic lupus erythematosus_Homo sapiens_hsa053222.24058169
12Nucleotide excision repair_Homo sapiens_hsa034202.15182876
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07208664
14RNA transport_Homo sapiens_hsa030132.03246394
15Primary immunodeficiency_Homo sapiens_hsa053401.70307276
16Herpes simplex infection_Homo sapiens_hsa051681.65558818
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.56733938
18p53 signaling pathway_Homo sapiens_hsa041151.56628219
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56261373
20Antigen processing and presentation_Homo sapiens_hsa046121.51733962
21Viral carcinogenesis_Homo sapiens_hsa052031.50772815
22mRNA surveillance pathway_Homo sapiens_hsa030151.50732478
23Olfactory transduction_Homo sapiens_hsa047401.46340553
24Measles_Homo sapiens_hsa051621.45774414
25Pyrimidine metabolism_Homo sapiens_hsa002401.42876169
26B cell receptor signaling pathway_Homo sapiens_hsa046621.41460539
27Ribosome_Homo sapiens_hsa030101.41046189
28RNA degradation_Homo sapiens_hsa030181.39519856
29Fatty acid biosynthesis_Homo sapiens_hsa000611.32845199
30Propanoate metabolism_Homo sapiens_hsa006401.31170533
31Small cell lung cancer_Homo sapiens_hsa052221.27041263
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21458068
33Protein export_Homo sapiens_hsa030601.21254706
34Epstein-Barr virus infection_Homo sapiens_hsa051691.20765411
35Leishmaniasis_Homo sapiens_hsa051401.18253924
36Chronic myeloid leukemia_Homo sapiens_hsa052201.15107568
37Butanoate metabolism_Homo sapiens_hsa006501.13780380
38HTLV-I infection_Homo sapiens_hsa051661.11463433
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.08119799
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.05310290
41Lysine degradation_Homo sapiens_hsa003101.04897551
42Influenza A_Homo sapiens_hsa051641.04019983
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04007534
44Apoptosis_Homo sapiens_hsa042101.03580815
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03493455
46Legionellosis_Homo sapiens_hsa051341.02790072
47Hematopoietic cell lineage_Homo sapiens_hsa046401.01685785
48RNA polymerase_Homo sapiens_hsa030201.01647650
49Osteoclast differentiation_Homo sapiens_hsa043801.01377954
50Hepatitis B_Homo sapiens_hsa051610.99504592
51Basal transcription factors_Homo sapiens_hsa030220.99051152
52MicroRNAs in cancer_Homo sapiens_hsa052060.98671871
53Phototransduction_Homo sapiens_hsa047440.94338142
54Nitrogen metabolism_Homo sapiens_hsa009100.91215512
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89414697
56T cell receptor signaling pathway_Homo sapiens_hsa046600.88186404
57Toxoplasmosis_Homo sapiens_hsa051450.86631004
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85956916
59Staphylococcus aureus infection_Homo sapiens_hsa051500.84842599
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83719844
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83201221
62Pancreatic cancer_Homo sapiens_hsa052120.80616463
63Huntingtons disease_Homo sapiens_hsa050160.79556844
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79236922
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78311908
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.76743136
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76322959
68Acute myeloid leukemia_Homo sapiens_hsa052210.74884765
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.73479458
70Viral myocarditis_Homo sapiens_hsa054160.73171641
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73127001
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72164372
73Selenocompound metabolism_Homo sapiens_hsa004500.71816279
74Pyruvate metabolism_Homo sapiens_hsa006200.71183769
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70406368
76Non-small cell lung cancer_Homo sapiens_hsa052230.70126014
77TNF signaling pathway_Homo sapiens_hsa046680.66890829
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66043805
79Colorectal cancer_Homo sapiens_hsa052100.64956042
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.63928854
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63458315
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62665566
83Proteasome_Homo sapiens_hsa030500.62054286
84Prostate cancer_Homo sapiens_hsa052150.60809264
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59608606
86Alcoholism_Homo sapiens_hsa050340.59032515
87Allograft rejection_Homo sapiens_hsa053300.58446045
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58150663
89Shigellosis_Homo sapiens_hsa051310.57704440
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.57026776
91Notch signaling pathway_Homo sapiens_hsa043300.55774638
92Fatty acid metabolism_Homo sapiens_hsa012120.55709363
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53931621
94Purine metabolism_Homo sapiens_hsa002300.53058918
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51726911
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48520149
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46743740
98Graft-versus-host disease_Homo sapiens_hsa053320.45250729
99FoxO signaling pathway_Homo sapiens_hsa040680.45077140
100Taste transduction_Homo sapiens_hsa047420.44967051
101Steroid biosynthesis_Homo sapiens_hsa001000.44472699
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44355567
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44132874
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43567011
105Metabolic pathways_Homo sapiens_hsa011000.43149611
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.42656393
107Parkinsons disease_Homo sapiens_hsa050120.42648415
108Platelet activation_Homo sapiens_hsa046110.42336997
109Pertussis_Homo sapiens_hsa051330.41702949
110Hepatitis C_Homo sapiens_hsa051600.41389040
111Tuberculosis_Homo sapiens_hsa051520.41382183
112Malaria_Homo sapiens_hsa051440.41374708
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41092286
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40710100
115Oxidative phosphorylation_Homo sapiens_hsa001900.40424483
116Dorso-ventral axis formation_Homo sapiens_hsa043200.39884302
117Biosynthesis of amino acids_Homo sapiens_hsa012300.39705262
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.39659882
119Adherens junction_Homo sapiens_hsa045200.39311467
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38622138
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36753779
122Pentose phosphate pathway_Homo sapiens_hsa000300.36533598
123mTOR signaling pathway_Homo sapiens_hsa041500.35997855
124Chemokine signaling pathway_Homo sapiens_hsa040620.34654524
125Pathways in cancer_Homo sapiens_hsa052000.34080824
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33976731
127Oocyte meiosis_Homo sapiens_hsa041140.33628194
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33600029
129Glycerolipid metabolism_Homo sapiens_hsa005610.33199980
130HIF-1 signaling pathway_Homo sapiens_hsa040660.32264711
131Proteoglycans in cancer_Homo sapiens_hsa052050.30562210
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29979596
133Fatty acid degradation_Homo sapiens_hsa000710.29886304
134Sulfur relay system_Homo sapiens_hsa041220.27950967
135TGF-beta signaling pathway_Homo sapiens_hsa043500.27391443
136Carbon metabolism_Homo sapiens_hsa012000.26824134
137Tryptophan metabolism_Homo sapiens_hsa003800.26160842
138ABC transporters_Homo sapiens_hsa020100.25213691
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.25129882
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23914942
141Linoleic acid metabolism_Homo sapiens_hsa005910.23910737
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21073201
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20414383
144Ether lipid metabolism_Homo sapiens_hsa005650.18463266
145Retinol metabolism_Homo sapiens_hsa008300.15682267
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.15055028
147Peroxisome_Homo sapiens_hsa041460.14689566
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14018366
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12124964
150N-Glycan biosynthesis_Homo sapiens_hsa005100.11845623
151Glutathione metabolism_Homo sapiens_hsa004800.10931725
152Circadian rhythm_Homo sapiens_hsa047100.09419227
153Inositol phosphate metabolism_Homo sapiens_hsa005620.09107479
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.08706930
155Melanoma_Homo sapiens_hsa052180.08661994
156Folate biosynthesis_Homo sapiens_hsa007900.07866729
157Fatty acid elongation_Homo sapiens_hsa000620.06615741
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.06200353
159Nicotine addiction_Homo sapiens_hsa050330.04979421
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04081663

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