ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.55362531
2	fucose catabolic process (GO:0019317)	4.39760290
3	L-fucose metabolic process (GO:0042354)	4.39760290
4	L-fucose catabolic process (GO:0042355)	4.39760290
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.30342955
6	epithelial cilium movement (GO:0003351)	4.00572637
7	response to pheromone (GO:0019236)	3.90638429
8	regulation of cilium movement (GO:0003352)	3.83505112
9	sperm motility (GO:0030317)	3.73927257
10	indole-containing compound catabolic process (GO:0042436)	3.54109645
11	indolalkylamine catabolic process (GO:0046218)	3.54109645
12	tryptophan catabolic process (GO:0006569)	3.54109645
13	cellular ketone body metabolic process (GO:0046950)	3.47464461
14	presynaptic membrane assembly (GO:0097105)	3.41928768
15	acrosome reaction (GO:0007340)	3.39564096
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.39402542
17	indolalkylamine metabolic process (GO:0006586)	3.38856976
18	negative regulation of telomere maintenance (GO:0032205)	3.32373602
19	piRNA metabolic process (GO:0034587)	3.30750988
20	multicellular organism reproduction (GO:0032504)	3.27526132
21	behavioral response to ethanol (GO:0048149)	3.26919202
22	DNA double-strand break processing (GO:0000729)	3.26437962
23	neural tube formation (GO:0001841)	3.22301187
24	cilium movement (GO:0003341)	3.22270815
25	ketone body metabolic process (GO:1902224)	3.10057389
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.09495226
27	cilium morphogenesis (GO:0060271)	3.07639731
28	axoneme assembly (GO:0035082)	3.06768201
29	otic vesicle formation (GO:0030916)	3.05479255
30	neuron fate determination (GO:0048664)	3.04552809
31	negative regulation of mast cell activation (GO:0033004)	3.04481680
32	platelet dense granule organization (GO:0060155)	3.04364988
33	central nervous system myelination (GO:0022010)	3.01824007
34	axon ensheathment in central nervous system (GO:0032291)	3.01824007
35	detection of light stimulus involved in visual perception (GO:0050908)	2.99099677
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.99099677
37	cilium or flagellum-dependent cell motility (GO:0001539)	2.98292825
38	cell wall macromolecule catabolic process (GO:0016998)	2.97286531
39	intraciliary transport (GO:0042073)	2.90899135
40	presynaptic membrane organization (GO:0097090)	2.87550917
41	establishment of protein localization to Golgi (GO:0072600)	2.87261604
42	DNA deamination (GO:0045006)	2.86511064
43	regulation of telomere maintenance (GO:0032204)	2.86249508
44	protein polyglutamylation (GO:0018095)	2.84294161
45	tryptophan metabolic process (GO:0006568)	2.84042102
46	cellular biogenic amine catabolic process (GO:0042402)	2.83522169
47	amine catabolic process (GO:0009310)	2.83522169
48	limb bud formation (GO:0060174)	2.81784743
49	male meiosis (GO:0007140)	2.78549730
50	cell wall macromolecule metabolic process (GO:0044036)	2.77606868
51	coenzyme catabolic process (GO:0009109)	2.76613438
52	axonemal dynein complex assembly (GO:0070286)	2.74175276
53	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.71120852
54	signal peptide processing (GO:0006465)	2.70622043
55	proline transport (GO:0015824)	2.70342515
56	reflex (GO:0060004)	2.69438723
57	DNA methylation involved in gamete generation (GO:0043046)	2.68769357
58	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67560329
59	retinal cone cell development (GO:0046549)	2.65101894
60	neuronal action potential (GO:0019228)	2.64670140
61	tongue development (GO:0043586)	2.64553675
62	cilium organization (GO:0044782)	2.64342605
63	protein targeting to Golgi (GO:0000042)	2.64295827
64	pyrimidine nucleobase catabolic process (GO:0006208)	2.63943718
65	protein localization to cilium (GO:0061512)	2.63052720
66	spermatid development (GO:0007286)	2.62677789
67	rhodopsin mediated signaling pathway (GO:0016056)	2.62197569
68	cilium assembly (GO:0042384)	2.60536169
69	synapsis (GO:0007129)	2.60085401
70	negative regulation of astrocyte differentiation (GO:0048712)	2.59604217
71	protein prenylation (GO:0018342)	2.56212350
72	prenylation (GO:0097354)	2.56212350
73	fucosylation (GO:0036065)	2.56082154
74	neuron cell-cell adhesion (GO:0007158)	2.55695922
75	indole-containing compound metabolic process (GO:0042430)	2.54683330
76	regulation of meiosis I (GO:0060631)	2.51574376
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50940319
78	polyol catabolic process (GO:0046174)	2.50686154
79	centriole replication (GO:0007099)	2.50289914
80	protein localization to Golgi apparatus (GO:0034067)	2.49487048
81	sulfation (GO:0051923)	2.48545360
82	regulation of action potential (GO:0098900)	2.47908499
83	seminiferous tubule development (GO:0072520)	2.47004725
84	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.46533871
85	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.46533871
86	NADH dehydrogenase complex assembly (GO:0010257)	2.46533871
87	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.46110729
88	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.45949781
89	forebrain neuron differentiation (GO:0021879)	2.45820727
90	regulation of microtubule-based movement (GO:0060632)	2.44778337
91	smoothened signaling pathway (GO:0007224)	2.44715915
92	protein complex biogenesis (GO:0070271)	2.44576976
93	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.42005541
94	xenobiotic catabolic process (GO:0042178)	2.40449299
95	ubiquinone metabolic process (GO:0006743)	2.39123207
96	kynurenine metabolic process (GO:0070189)	2.37165058
97	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.36149330
98	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.36149330
99	regulation of translation, ncRNA-mediated (GO:0045974)	2.36149330
100	regulation of gene silencing by miRNA (GO:0060964)	2.36043376

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.45632434
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34984543
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.14523786
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.10078145
5	VDR_22108803_ChIP-Seq_LS180_Human	2.96903032
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.74002375
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59871450
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47977972
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.41963961
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.41814109
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35769379
12	FUS_26573619_Chip-Seq_HEK293_Human	2.34866139
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.29471201
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28912923
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.18133447
16	P300_19829295_ChIP-Seq_ESCs_Human	2.16015812
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14074248
18	EWS_26573619_Chip-Seq_HEK293_Human	2.08836796
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01362741
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.83770447
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.78864668
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78864668
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.77441934
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.72902210
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71738136
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.68373129
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68373129
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.65055791
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63995664
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61617839
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56580345
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56408363
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55874125
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54183728
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53127000
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.52019675
37	AR_25329375_ChIP-Seq_VCAP_Human	1.51201564
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47676806
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46030888
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45438564
41	STAT3_23295773_ChIP-Seq_U87_Human	1.44369230
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43567988
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42594756
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42440311
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41678055
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.41664180
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41656296
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41656296
49	TCF4_23295773_ChIP-Seq_U87_Human	1.40815555
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40146477
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39888888
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35447079
53	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.35365014
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.30918453
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29530817
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29182829
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28475806
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.27569558
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.26806460
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22855114
61	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.22095232
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20306332
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20267151
64	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18899412
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18206531
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17948274
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17832468
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17609155
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17609155
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15957745
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14891329
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13463502
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13234111
74	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12550698
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11899651
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11261590
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10801215
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10768923
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10123958
80	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08620152
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08250442
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06290707
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04333687
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03954887
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03506527
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02558241
87	RXR_22108803_ChIP-Seq_LS180_Human	1.00406516
88	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99962921
89	CDX2_22108803_ChIP-Seq_LS180_Human	0.98692135
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97883411
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.97744174
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97454374
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96913308
94	NCOR_22424771_ChIP-Seq_293T_Human	0.96832380
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96805056
96	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.96751430
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.96235516
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95937738
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.94409950
100	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.93837790

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	2.97224484
2	MP0000569_abnormal_digit_pigmentation	2.72865472
3	MP0005646_abnormal_pituitary_gland	2.48460957
4	MP0002837_dystrophic_cardiac_calcinosis	2.47648595
5	MP0005551_abnormal_eye_electrophysiolog	2.31504332
6	MP0008877_abnormal_DNA_methylation	2.25194246
7	MP0006072_abnormal_retinal_apoptosis	2.18566473
8	MP0001968_abnormal_touch/_nociception	2.14048418
9	MP0005645_abnormal_hypothalamus_physiol	2.12029428
10	MP0001529_abnormal_vocalization	2.08475241
11	MP0002163_abnormal_gland_morphology	2.04988645
12	MP0002102_abnormal_ear_morphology	2.04321059
13	MP0002638_abnormal_pupillary_reflex	2.02401816
14	MP0005410_abnormal_fertilization	1.97381046
15	MP0006276_abnormal_autonomic_nervous	1.91588370
16	MP0001984_abnormal_olfaction	1.87600396
17	MP0005253_abnormal_eye_physiology	1.86435441
18	MP0003880_abnormal_central_pattern	1.80937671
19	MP0006292_abnormal_olfactory_placode	1.78434885
20	MP0008872_abnormal_physiological_respon	1.73265615
21	MP0002938_white_spotting	1.71517974
22	MP0009046_muscle_twitch	1.70677375
23	MP0004133_heterotaxia	1.68285562
24	MP0003787_abnormal_imprinting	1.68015071
25	MP0003646_muscle_fatigue	1.67538633
26	MP0009745_abnormal_behavioral_response	1.65973735
27	MP0002272_abnormal_nervous_system	1.64760553
28	MP0002876_abnormal_thyroid_physiology	1.64290439
29	MP0005379_endocrine/exocrine_gland_phen	1.63797767
30	MP0001485_abnormal_pinna_reflex	1.60282143
31	MP0008875_abnormal_xenobiotic_pharmacok	1.54022630
32	MP0002736_abnormal_nociception_after	1.52953829
33	MP0000631_abnormal_neuroendocrine_gland	1.52156556
34	MP0002653_abnormal_ependyma_morphology	1.48395208
35	MP0001501_abnormal_sleep_pattern	1.44778602
36	MP0005174_abnormal_tail_pigmentation	1.42944878
37	MP0004142_abnormal_muscle_tone	1.39595265
38	MP0002557_abnormal_social/conspecific_i	1.37101452
39	MP0000372_irregular_coat_pigmentation	1.36270000
40	MP0000566_synostosis	1.36201269
41	MP0001486_abnormal_startle_reflex	1.33096481
42	MP0003195_calcinosis	1.31104042
43	MP0004885_abnormal_endolymph	1.30837283
44	MP0008789_abnormal_olfactory_epithelium	1.27052210
45	MP0002572_abnormal_emotion/affect_behav	1.26779168
46	MP0010386_abnormal_urinary_bladder	1.26722559
47	MP0001905_abnormal_dopamine_level	1.25421785
48	MP0003698_abnormal_male_reproductive	1.24851337
49	MP0002928_abnormal_bile_duct	1.23738550
50	MP0005075_abnormal_melanosome_morpholog	1.20943585
51	MP0005084_abnormal_gallbladder_morpholo	1.19950559
52	MP0001970_abnormal_pain_threshold	1.17859780
53	MP0005167_abnormal_blood-brain_barrier	1.17816851
54	MP0002733_abnormal_thermal_nociception	1.16792038
55	MP0003011_delayed_dark_adaptation	1.16382601
56	MP0001929_abnormal_gametogenesis	1.14052561
57	MP0008995_early_reproductive_senescence	1.08467982
58	MP0002160_abnormal_reproductive_system	1.07301973
59	MP0004147_increased_porphyrin_level	1.03371412
60	MP0005187_abnormal_penis_morphology	1.02462384
61	MP0005394_taste/olfaction_phenotype	1.02427538
62	MP0005499_abnormal_olfactory_system	1.02427538
63	MP0000778_abnormal_nervous_system	1.01146990
64	MP0002282_abnormal_trachea_morphology	1.01009671
65	MP0004924_abnormal_behavior	1.00571992
66	MP0005386_behavior/neurological_phenoty	1.00571992
67	MP0002138_abnormal_hepatobiliary_system	1.00392390
68	MP0000026_abnormal_inner_ear	0.99996054
69	MP0000427_abnormal_hair_cycle	0.99223256
70	MP0002735_abnormal_chemical_nociception	0.99107042
71	MP0002064_seizures	0.97393875
72	MP0003635_abnormal_synaptic_transmissio	0.96981801
73	MP0009780_abnormal_chondrocyte_physiolo	0.96904249
74	MP0002184_abnormal_innervation	0.96431797
75	MP0002095_abnormal_skin_pigmentation	0.95887292
76	MP0003718_maternal_effect	0.95779370
77	MP0003121_genomic_imprinting	0.94936749
78	MP0005195_abnormal_posterior_eye	0.94815440
79	MP0002233_abnormal_nose_morphology	0.91143185
80	MP0002210_abnormal_sex_determination	0.90203833
81	MP0002752_abnormal_somatic_nervous	0.89337319
82	MP0000230_abnormal_systemic_arterial	0.89172441
83	MP0001986_abnormal_taste_sensitivity	0.88707466
84	MP0000383_abnormal_hair_follicle	0.88250105
85	MP0000049_abnormal_middle_ear	0.86887458
86	MP0002751_abnormal_autonomic_nervous	0.85452705
87	MP0001764_abnormal_homeostasis	0.85451465
88	MP0001963_abnormal_hearing_physiology	0.84436507
89	MP0009697_abnormal_copulation	0.84095925
90	MP0002127_abnormal_cardiovascular_syste	0.83586661
91	MP0002277_abnormal_respiratory_mucosa	0.83416322
92	MP0003252_abnormal_bile_duct	0.83351571
93	MP0004742_abnormal_vestibular_system	0.83199471
94	MP0002693_abnormal_pancreas_physiology	0.83023855
95	MP0001944_abnormal_pancreas_morphology	0.82717362
96	MP0002067_abnormal_sensory_capabilities	0.82619496
97	MP0000653_abnormal_sex_gland	0.82479477
98	MP0003122_maternal_imprinting	0.81950434
99	MP0004145_abnormal_muscle_electrophysio	0.81824974
100	MP0005391_vision/eye_phenotype	0.81601830

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.38119488
2	Pancreatic fibrosis (HP:0100732)	4.26901077
3	True hermaphroditism (HP:0010459)	4.05711024
4	Molar tooth sign on MRI (HP:0002419)	3.91885516
5	Abnormality of midbrain morphology (HP:0002418)	3.91885516
6	Congenital stationary night blindness (HP:0007642)	3.36969311
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.26820535
8	Type II lissencephaly (HP:0007260)	3.25078116
9	Nephronophthisis (HP:0000090)	3.20395417
10	Chronic hepatic failure (HP:0100626)	3.08228986
11	Attenuation of retinal blood vessels (HP:0007843)	3.03012369
12	Abolished electroretinogram (ERG) (HP:0000550)	3.02676687
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.00691122
14	Abnormality of the renal cortex (HP:0011035)	2.95312863
15	Bony spicule pigmentary retinopathy (HP:0007737)	2.91810025
16	Intestinal atresia (HP:0011100)	2.87630912
17	Abnormality of the renal medulla (HP:0100957)	2.84729185
18	Cystic liver disease (HP:0006706)	2.71900644
19	Median cleft lip (HP:0000161)	2.60196325
20	Medial flaring of the eyebrow (HP:0010747)	2.59881009
21	Renal cortical cysts (HP:0000803)	2.56553434
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.54365708
23	Absent/shortened dynein arms (HP:0200106)	2.54365708
24	Sclerocornea (HP:0000647)	2.51854402
25	Hyperventilation (HP:0002883)	2.40178039
26	Inability to walk (HP:0002540)	2.36442656
27	Cerebellar dysplasia (HP:0007033)	2.36090988
28	Gastrointestinal atresia (HP:0002589)	2.32691784
29	Hypothermia (HP:0002045)	2.31717504
30	Abnormal ciliary motility (HP:0012262)	2.31216041
31	Optic nerve hypoplasia (HP:0000609)	2.30847834
32	Polydipsia (HP:0001959)	2.28844398
33	Abnormal drinking behavior (HP:0030082)	2.28844398
34	Male pseudohermaphroditism (HP:0000037)	2.26457310
35	Decreased central vision (HP:0007663)	2.22626046
36	Polyuria (HP:0000103)	2.21774466
37	Abnormality of the labia minora (HP:0012880)	2.21445100
38	Bile duct proliferation (HP:0001408)	2.19817296
39	Abnormal biliary tract physiology (HP:0012439)	2.19817296
40	Pendular nystagmus (HP:0012043)	2.19600881
41	Acute necrotizing encephalopathy (HP:0006965)	2.17889188
42	Anencephaly (HP:0002323)	2.17438131
43	Postaxial foot polydactyly (HP:0001830)	2.16813624
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.15592571
45	Tubular atrophy (HP:0000092)	2.15428422
46	Focal motor seizures (HP:0011153)	2.13158165
47	Increased CSF lactate (HP:0002490)	2.12150122
48	Thyroiditis (HP:0100646)	2.09896353
49	Occipital encephalocele (HP:0002085)	2.09008106
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08672312
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.08300700
52	Congenital hepatic fibrosis (HP:0002612)	2.07254748
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05602176
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.05602176
55	Mitochondrial inheritance (HP:0001427)	2.05290361
56	Preaxial hand polydactyly (HP:0001177)	2.04975349
57	Gait imbalance (HP:0002141)	2.03097153
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02173008
59	Progressive macrocephaly (HP:0004481)	2.02153261
60	Postaxial hand polydactyly (HP:0001162)	2.01987195
61	Congenital primary aphakia (HP:0007707)	1.99317266
62	Abnormal respiratory motile cilium physiology (HP:0012261)	1.99292058
63	Retinal dysplasia (HP:0007973)	1.97342163
64	Acute encephalopathy (HP:0006846)	1.96662985
65	Dialeptic seizures (HP:0011146)	1.96085395
66	Genital tract atresia (HP:0001827)	1.96077739
67	Lissencephaly (HP:0001339)	1.95627981
68	Febrile seizures (HP:0002373)	1.94590948
69	Asplenia (HP:0001746)	1.93923258
70	Abnormality of macular pigmentation (HP:0008002)	1.92128494
71	Abnormal urine output (HP:0012590)	1.91715730
72	Optic disc pallor (HP:0000543)	1.91629006
73	Pachygyria (HP:0001302)	1.90360824
74	Colon cancer (HP:0003003)	1.89321458
75	Hemiparesis (HP:0001269)	1.88504403
76	Focal seizures (HP:0007359)	1.86542459
77	Polyphagia (HP:0002591)	1.86046622
78	Increased corneal curvature (HP:0100692)	1.85734288
79	Keratoconus (HP:0000563)	1.85734288
80	Constricted visual fields (HP:0001133)	1.84786615
81	Vaginal atresia (HP:0000148)	1.83792994
82	Oligodactyly (hands) (HP:0001180)	1.83458429
83	Congenital sensorineural hearing impairment (HP:0008527)	1.83235893
84	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82339148
85	Facial hemangioma (HP:0000329)	1.81500922
86	Short tibia (HP:0005736)	1.81496383
87	Large for gestational age (HP:0001520)	1.78414737
88	Progressive inability to walk (HP:0002505)	1.78003440
89	Hyperglycinuria (HP:0003108)	1.76332471
90	Broad-based gait (HP:0002136)	1.75445457
91	Lipid accumulation in hepatocytes (HP:0006561)	1.75264228
92	Narrow forehead (HP:0000341)	1.75244169
93	Methylmalonic aciduria (HP:0012120)	1.74875973
94	Hypomagnesemia (HP:0002917)	1.74589496
95	Glycosuria (HP:0003076)	1.73820650
96	Abnormality of urine glucose concentration (HP:0011016)	1.73820650
97	3-Methylglutaconic aciduria (HP:0003535)	1.73143969
98	Furrowed tongue (HP:0000221)	1.72488929
99	Nephrogenic diabetes insipidus (HP:0009806)	1.71910161
100	Abnormal sex determination (HP:0012244)	1.71743822

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.93474164
2	PINK1	4.06272224
3	MAP4K2	3.18999704
4	NUAK1	2.81672031
5	CASK	2.71471667
6	ZAK	2.64090395
7	ADRBK2	2.62287526
8	TLK1	2.57468558
9	BMPR1B	2.26908772
10	WNK3	2.11608074
11	GRK1	2.02379163
12	MAP2K7	1.80038707
13	NEK1	1.76153189
14	FGFR2	1.73180403
15	MAPK13	1.67413489
16	TAF1	1.66999949
17	TAOK3	1.64302676
18	WNK4	1.60562550
19	MAP3K4	1.57161137
20	STK38L	1.51942503
21	CSNK1G2	1.51548006
22	TNIK	1.50695473
23	VRK1	1.47370057
24	MARK1	1.45869826
25	STK39	1.43277617
26	ACVR1B	1.39889944
27	CSNK1G3	1.37495261
28	CSNK1G1	1.36373889
29	OXSR1	1.36177709
30	MARK3	1.34709050
31	NLK	1.34629096
32	CSNK1A1L	1.26289006
33	VRK2	1.25972746
34	PNCK	1.23533476
35	INSRR	1.22292452
36	DYRK2	1.19029267
37	PAK3	1.11909100
38	EIF2AK3	1.04059119
39	OBSCN	1.02935601
40	TIE1	0.95085051
41	PLK2	0.94290146
42	MAP2K6	0.92757814
43	PIK3CG	0.91946809
44	NTRK2	0.85622540
45	MAP3K9	0.85105473
46	PRKCG	0.84814379
47	LATS1	0.83167430
48	PHKG2	0.83071609
49	PHKG1	0.83071609
50	ADRBK1	0.82130752
51	NEK2	0.81324482
52	PTK2B	0.80346847
53	DAPK2	0.77859441
54	TGFBR1	0.76133254
55	PLK4	0.74739365
56	STK16	0.73167254
57	PRKCE	0.68887022
58	NME1	0.65525952
59	BCR	0.64036041
60	MUSK	0.64010667
61	TRIM28	0.62964769
62	RPS6KA5	0.62549603
63	CDK3	0.62224293
64	PRKCQ	0.60008121
65	CDK8	0.59580437
66	WEE1	0.58488845
67	MAPK15	0.55920331
68	MKNK2	0.54564785
69	GRK5	0.54383743
70	NTRK3	0.54177133
71	SGK494	0.53729393
72	SGK223	0.53729393
73	DYRK3	0.52932370
74	MYLK	0.51524430
75	PRKG1	0.48731206
76	MST4	0.45114669
77	MAP3K5	0.43197552
78	PRKACA	0.41180462
79	MAPKAPK5	0.41159942
80	CDC7	0.40808439
81	SGK2	0.39469079
82	CAMK2A	0.38753701
83	TEC	0.38356527
84	ATM	0.38329351
85	PKN1	0.37308326
86	CSNK1A1	0.37189878
87	DAPK3	0.36522890
88	EPHA4	0.36220051
89	STK3	0.32124806
90	CDK5	0.31479172
91	BCKDK	0.31347440
92	CAMK1	0.30122870
93	ROCK1	0.29595666
94	KIT	0.28030716
95	STK11	0.27822500
96	MINK1	0.27819720
97	PRKAA1	0.26873422
98	MAP3K12	0.26823386
99	PRKAA2	0.25196103
100	PIK3CA	0.24666583

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.58487934
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.75919536
3	Butanoate metabolism_Homo sapiens_hsa00650	2.68354273
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.47727377
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.41803085
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.24930399
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19321168
8	Olfactory transduction_Homo sapiens_hsa04740	2.13593481
9	Protein export_Homo sapiens_hsa03060	2.07077296
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03569891
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.97234438
12	Asthma_Homo sapiens_hsa05310	1.96728031
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.93676614
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.90016670
15	Parkinsons disease_Homo sapiens_hsa05012	1.83473679
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.78619084
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70520702
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67977954
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.66559285
20	Taste transduction_Homo sapiens_hsa04742	1.64778242
21	Propanoate metabolism_Homo sapiens_hsa00640	1.64310790
22	Basal transcription factors_Homo sapiens_hsa03022	1.60017011
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56418065
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56374108
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56254352
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.55379794
27	Nicotine addiction_Homo sapiens_hsa05033	1.54309202
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44081512
29	Homologous recombination_Homo sapiens_hsa03440	1.43451990
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.43173091
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.40250525
32	Caffeine metabolism_Homo sapiens_hsa00232	1.39205775
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27813038
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.27416251
35	Allograft rejection_Homo sapiens_hsa05330	1.24105768
36	Huntingtons disease_Homo sapiens_hsa05016	1.18571205
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18441530
38	RNA degradation_Homo sapiens_hsa03018	1.18053442
39	Alzheimers disease_Homo sapiens_hsa05010	1.16306841
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.14955045
41	Regulation of autophagy_Homo sapiens_hsa04140	1.11444166
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.08881453
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.05360386
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.04532588
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00653822
46	Alcoholism_Homo sapiens_hsa05034	1.00068156
47	Peroxisome_Homo sapiens_hsa04146	0.99188240
48	RNA polymerase_Homo sapiens_hsa03020	0.97313397
49	Purine metabolism_Homo sapiens_hsa00230	0.96341355
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95873741
51	Salivary secretion_Homo sapiens_hsa04970	0.94043428
52	Morphine addiction_Homo sapiens_hsa05032	0.92678049
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92675897
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90295414
55	Retinol metabolism_Homo sapiens_hsa00830	0.89666595
56	Circadian entrainment_Homo sapiens_hsa04713	0.88890841
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84841105
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84392777
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.81781621
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.80769089
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80427931
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.79561973
63	One carbon pool by folate_Homo sapiens_hsa00670	0.79046802
64	Proteasome_Homo sapiens_hsa03050	0.78305512
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77511435
66	GABAergic synapse_Homo sapiens_hsa04727	0.77033213
67	Insulin secretion_Homo sapiens_hsa04911	0.76178890
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.73475161
69	ABC transporters_Homo sapiens_hsa02010	0.66992908
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66548150
71	Fatty acid degradation_Homo sapiens_hsa00071	0.65014521
72	Renin secretion_Homo sapiens_hsa04924	0.63958760
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.63602684
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61980121
75	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59848631
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59038471
77	Metabolic pathways_Homo sapiens_hsa01100	0.59018831
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.57811837
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53479670
80	Glutathione metabolism_Homo sapiens_hsa00480	0.51155345
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50849753
82	Serotonergic synapse_Homo sapiens_hsa04726	0.49910315
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48208444
84	Mineral absorption_Homo sapiens_hsa04978	0.44905871
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43164313
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39672940
87	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38593419
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38237415
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.38159214
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.37567456
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37428633
92	Ribosome_Homo sapiens_hsa03010	0.37300285
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37298716
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.36908864
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36884294
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34531777
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34326392
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33787829
99	Sulfur relay system_Homo sapiens_hsa04122	0.32551512
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.31006182

CEP164P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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