ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	5.48358238
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.37917015
3	response to pheromone (GO:0019236)	4.93164465
4	protein polyglutamylation (GO:0018095)	4.71202270
5	regulation of cilium movement (GO:0003352)	4.61695753
6	positive regulation of mitochondrial fission (GO:0090141)	4.55016213
7	sperm motility (GO:0030317)	4.44456955
8	microtubule depolymerization (GO:0007019)	4.41662380
9	nonmotile primary cilium assembly (GO:0035058)	4.22435018
10	nucleobase catabolic process (GO:0046113)	4.20404240
11	cilium or flagellum-dependent cell motility (GO:0001539)	4.16531450
12	neuron cell-cell adhesion (GO:0007158)	4.07600799
13	centriole replication (GO:0007099)	3.95359636
14	epithelial cilium movement (GO:0003351)	3.94168337
15	DNA double-strand break processing (GO:0000729)	3.92700335
16	intraciliary transport (GO:0042073)	3.83451051
17	axoneme assembly (GO:0035082)	3.70265874
18	protein localization to cilium (GO:0061512)	3.64658204
19	single strand break repair (GO:0000012)	3.47799165
20	cilium movement (GO:0003341)	3.44670186
21	presynaptic membrane assembly (GO:0097105)	3.41501618
22	spermatid development (GO:0007286)	3.37941433
23	calcium ion-dependent exocytosis (GO:0017156)	3.30906050
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30031532
25	establishment of protein localization to Golgi (GO:0072600)	3.29293232
26	protein localization to synapse (GO:0035418)	3.28506482
27	retinal cone cell development (GO:0046549)	3.28408683
28	axonemal dynein complex assembly (GO:0070286)	3.23831551
29	protein targeting to Golgi (GO:0000042)	3.21492309
30	microtubule polymerization or depolymerization (GO:0031109)	3.19244092
31	cilium organization (GO:0044782)	3.18718437
32	postsynaptic membrane organization (GO:0001941)	3.17057572
33	seminiferous tubule development (GO:0072520)	3.16719760
34	regulation of telomere maintenance (GO:0032204)	3.15941970
35	retinal rod cell development (GO:0046548)	3.13562490
36	neural tube formation (GO:0001841)	3.11420548
37	sperm-egg recognition (GO:0035036)	3.10886927
38	ubiquinone metabolic process (GO:0006743)	3.10015241
39	negative regulation of telomere maintenance (GO:0032205)	3.07805782
40	cilium assembly (GO:0042384)	3.07003874
41	left/right axis specification (GO:0070986)	3.06669363
42	vocalization behavior (GO:0071625)	3.05244722
43	regulation of microtubule-based movement (GO:0060632)	3.05058068
44	cilium morphogenesis (GO:0060271)	3.05025196
45	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.02645757
46	glycosphingolipid biosynthetic process (GO:0006688)	2.99934350
47	spermatid nucleus differentiation (GO:0007289)	2.98200948
48	protein-cofactor linkage (GO:0018065)	2.95904026
49	histone H2A acetylation (GO:0043968)	2.93468772
50	cellular ketone body metabolic process (GO:0046950)	2.91656708
51	DNA integration (GO:0015074)	2.90400230
52	ubiquinone biosynthetic process (GO:0006744)	2.85110597
53	regulation of development, heterochronic (GO:0040034)	2.85004360
54	piRNA metabolic process (GO:0034587)	2.84986122
55	presynaptic membrane organization (GO:0097090)	2.84400691
56	regulation of mitochondrial fission (GO:0090140)	2.84226221
57	olfactory bulb development (GO:0021772)	2.83691717
58	fusion of sperm to egg plasma membrane (GO:0007342)	2.83206362
59	neurotransmitter-gated ion channel clustering (GO:0072578)	2.82612335
60	protein localization to Golgi apparatus (GO:0034067)	2.82414750
61	establishment of mitochondrion localization (GO:0051654)	2.81306472
62	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.81019031
63	multicellular organism reproduction (GO:0032504)	2.80288301
64	gamma-aminobutyric acid transport (GO:0015812)	2.79315933
65	protein deneddylation (GO:0000338)	2.78931739
66	behavioral response to nicotine (GO:0035095)	2.77996922
67	negative regulation of mast cell activation (GO:0033004)	2.77297844
68	cullin deneddylation (GO:0010388)	2.77208929
69	L-fucose catabolic process (GO:0042355)	2.76509310
70	fucose catabolic process (GO:0019317)	2.76509310
71	L-fucose metabolic process (GO:0042354)	2.76509310
72	indolalkylamine metabolic process (GO:0006586)	2.76305288
73	somite development (GO:0061053)	2.76197706
74	binding of sperm to zona pellucida (GO:0007339)	2.73292569
75	ketone body metabolic process (GO:1902224)	2.71101449
76	regulation of feeding behavior (GO:0060259)	2.65513954
77	sialylation (GO:0097503)	2.65248885
78	synapse assembly (GO:0007416)	2.65177015
79	pyrimidine dimer repair (GO:0006290)	2.62672971
80	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.62425441
81	positive regulation of action potential (GO:0045760)	2.61851825
82	centriole assembly (GO:0098534)	2.61449732
83	head development (GO:0060322)	2.59356233
84	regulation of timing of cell differentiation (GO:0048505)	2.58769996
85	platelet dense granule organization (GO:0060155)	2.57789355
86	tryptophan catabolic process (GO:0006569)	2.57656627
87	indole-containing compound catabolic process (GO:0042436)	2.57656627
88	indolalkylamine catabolic process (GO:0046218)	2.57656627
89	limb bud formation (GO:0060174)	2.57435299
90	cellular biogenic amine catabolic process (GO:0042402)	2.56609289
91	amine catabolic process (GO:0009310)	2.56609289
92	photoreceptor cell maintenance (GO:0045494)	2.56406965
93	C4-dicarboxylate transport (GO:0015740)	2.56324632
94	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.54886370
95	neurofilament cytoskeleton organization (GO:0060052)	2.53758705
96	retinal ganglion cell axon guidance (GO:0031290)	2.53445042
97	brain morphogenesis (GO:0048854)	2.53406880
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50650361
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50650361
100	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.49745341

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.14021764
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.55964966
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.41646379
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.81860931
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.79003791
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72841522
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.71327387
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55594241
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.54802844
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.49515713
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38592952
12	FUS_26573619_Chip-Seq_HEK293_Human	2.37082249
13	VDR_22108803_ChIP-Seq_LS180_Human	2.34424225
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.34314392
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34129350
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24900877
17	P300_19829295_ChIP-Seq_ESCs_Human	2.17713061
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01503501
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01089248
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97153333
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.94451732
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.94451732
23	EWS_26573619_Chip-Seq_HEK293_Human	1.86916686
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.79815984
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72186335
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.71723620
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69723524
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67095359
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66184382
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.66164579
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62467454
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.54837521
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53444722
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53073263
35	AR_25329375_ChIP-Seq_VCAP_Human	1.51052223
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50356856
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49550748
38	STAT3_23295773_ChIP-Seq_U87_Human	1.49542046
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48413014
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47921935
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46895498
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46785066
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.46664886
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45165207
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44631774
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44631774
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44458125
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42124736
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41119467
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39173157
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.38515687
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37254538
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36171989
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35369024
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33590583
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29766733
57	TCF4_23295773_ChIP-Seq_U87_Human	1.29648706
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26388101
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26388101
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22055185
61	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.21939991
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.20853772
63	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19561599
64	ELK1_19687146_ChIP-ChIP_HELA_Human	1.19549037
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19223377
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.18497737
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18256086
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17981608
69	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17767219
70	VDR_23849224_ChIP-Seq_CD4+_Human	1.16588666
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16036447
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14075740
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12534526
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11805421
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11685879
76	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11474343
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09065013
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08150666
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.08026679
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07394543
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.06943809
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06856695
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06685367
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03454393
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03344677
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02947696
87	JUN_21703547_ChIP-Seq_K562_Human	1.02660716
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01231513
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00769304
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00769304
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99430046
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98318423
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.97726626
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97495223
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97098212
96	NCOR_22424771_ChIP-Seq_293T_Human	0.96947046
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94529246
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.94206365
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93092581
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92362039

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.80100661
2	MP0003880_abnormal_central_pattern	3.19480060
3	MP0001529_abnormal_vocalization	3.05099374
4	MP0005410_abnormal_fertilization	2.98065622
5	MP0006276_abnormal_autonomic_nervous	2.58272795
6	MP0008877_abnormal_DNA_methylation	2.57911494
7	MP0002822_catalepsy	2.54937550
8	MP0003787_abnormal_imprinting	2.49471969
9	MP0002736_abnormal_nociception_after	2.41454511
10	MP0009046_muscle_twitch	2.37120459
11	MP0005394_taste/olfaction_phenotype	2.22594577
12	MP0005499_abnormal_olfactory_system	2.22594577
13	MP0001968_abnormal_touch/_nociception	2.21894308
14	MP0004859_abnormal_synaptic_plasticity	2.18443482
15	MP0005645_abnormal_hypothalamus_physiol	2.02671177
16	MP0001984_abnormal_olfaction	2.02550566
17	MP0005084_abnormal_gallbladder_morpholo	2.01127559
18	MP0008789_abnormal_olfactory_epithelium	1.95464723
19	MP0008058_abnormal_DNA_repair	1.88666046
20	MP0002735_abnormal_chemical_nociception	1.87610689
21	MP0005253_abnormal_eye_physiology	1.79472345
22	MP0005551_abnormal_eye_electrophysiolog	1.79157797
23	MP0002272_abnormal_nervous_system	1.75821837
24	MP0006292_abnormal_olfactory_placode	1.73646476
25	MP0003121_genomic_imprinting	1.70716095
26	MP0000778_abnormal_nervous_system	1.69895625
27	MP0001486_abnormal_startle_reflex	1.69858142
28	MP0004270_analgesia	1.69021719
29	MP0001188_hyperpigmentation	1.68853957
30	MP0004142_abnormal_muscle_tone	1.66566358
31	MP0003122_maternal_imprinting	1.63189201
32	MP0003635_abnormal_synaptic_transmissio	1.62499140
33	MP0009745_abnormal_behavioral_response	1.60725074
34	MP0002653_abnormal_ependyma_morphology	1.57940302
35	MP0003698_abnormal_male_reproductive	1.57824045
36	MP0002572_abnormal_emotion/affect_behav	1.54910505
37	MP0006072_abnormal_retinal_apoptosis	1.54876383
38	MP0002638_abnormal_pupillary_reflex	1.51390619
39	MP0000569_abnormal_digit_pigmentation	1.50829062
40	MP0002234_abnormal_pharynx_morphology	1.48439954
41	MP0003195_calcinosis	1.41688300
42	MP0001929_abnormal_gametogenesis	1.39177801
43	MP0002751_abnormal_autonomic_nervous	1.38931422
44	MP0002557_abnormal_social/conspecific_i	1.35917638
45	MP0000049_abnormal_middle_ear	1.35100874
46	MP0002734_abnormal_mechanical_nocicepti	1.34425164
47	MP0001905_abnormal_dopamine_level	1.33557519
48	MP0002063_abnormal_learning/memory/cond	1.31044838
49	MP0002733_abnormal_thermal_nociception	1.30575563
50	MP0004133_heterotaxia	1.30231242
51	MP0002067_abnormal_sensory_capabilities	1.27292414
52	MP0004924_abnormal_behavior	1.25186364
53	MP0005386_behavior/neurological_phenoty	1.25186364
54	MP0004147_increased_porphyrin_level	1.24954868
55	MP0001970_abnormal_pain_threshold	1.21562414
56	MP0002184_abnormal_innervation	1.21368043
57	MP0004811_abnormal_neuron_physiology	1.19730124
58	MP0005423_abnormal_somatic_nervous	1.15365872
59	MP0000955_abnormal_spinal_cord	1.15264277
60	MP0003646_muscle_fatigue	1.10090253
61	MP0002752_abnormal_somatic_nervous	1.08700787
62	MP0000631_abnormal_neuroendocrine_gland	1.08552607
63	MP0004885_abnormal_endolymph	1.06904148
64	MP0002882_abnormal_neuron_morphology	1.06426682
65	MP0003718_maternal_effect	1.06390492
66	MP0009697_abnormal_copulation	1.06299186
67	MP0000372_irregular_coat_pigmentation	1.05799464
68	MP0002064_seizures	1.03830425
69	MP0006035_abnormal_mitochondrial_morpho	1.02368118
70	MP0000026_abnormal_inner_ear	0.99641851
71	MP0002837_dystrophic_cardiac_calcinosis	0.93444612
72	MP0002229_neurodegeneration	0.92461224
73	MP0003119_abnormal_digestive_system	0.91977201
74	MP0001177_atelectasis	0.90692817
75	MP0001764_abnormal_homeostasis	0.89763231
76	MP0002233_abnormal_nose_morphology	0.89250940
77	MP0003221_abnormal_cardiomyocyte_apopto	0.89033976
78	MP0008995_early_reproductive_senescence	0.88135207
79	MP0001293_anophthalmia	0.86560100
80	MP0002282_abnormal_trachea_morphology	0.86189039
81	MP0001502_abnormal_circadian_rhythm	0.84498274
82	MP0001485_abnormal_pinna_reflex	0.83881163
83	MP0005195_abnormal_posterior_eye	0.83833810
84	MP0003890_abnormal_embryonic-extraembry	0.83768648
85	MP0005367_renal/urinary_system_phenotyp	0.83724653
86	MP0000516_abnormal_urinary_system	0.83724653
87	MP0004742_abnormal_vestibular_system	0.83611651
88	MP0002069_abnormal_eating/drinking_beha	0.82687082
89	MP0002210_abnormal_sex_determination	0.82591250
90	MP0001963_abnormal_hearing_physiology	0.82434201
91	MP0005391_vision/eye_phenotype	0.80920515
92	MP0008872_abnormal_physiological_respon	0.78908619
93	MP0005248_abnormal_Harderian_gland	0.78318028
94	MP0002152_abnormal_brain_morphology	0.75973674
95	MP0003137_abnormal_impulse_conducting	0.75710857
96	MP0004085_abnormal_heartbeat	0.75467885
97	MP0000647_abnormal_sebaceous_gland	0.75467173
98	MP0004215_abnormal_myocardial_fiber	0.75292332
99	MP0001986_abnormal_taste_sensitivity	0.75080726
100	MP0010386_abnormal_urinary_bladder	0.74583907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.77607154
2	Molar tooth sign on MRI (HP:0002419)	3.63888813
3	Abnormality of midbrain morphology (HP:0002418)	3.63888813
4	Gait imbalance (HP:0002141)	3.60759486
5	Tubulointerstitial nephritis (HP:0001970)	3.59378391
6	Congenital primary aphakia (HP:0007707)	3.46277565
7	Nephronophthisis (HP:0000090)	3.39445628
8	Nephrogenic diabetes insipidus (HP:0009806)	3.34764348
9	Lissencephaly (HP:0001339)	3.29056021
10	Amyotrophic lateral sclerosis (HP:0007354)	3.13070598
11	Pancreatic cysts (HP:0001737)	3.12778269
12	True hermaphroditism (HP:0010459)	3.03212861
13	Retinal dysplasia (HP:0007973)	3.01655044
14	Chronic hepatic failure (HP:0100626)	2.93253584
15	Abnormality of the renal medulla (HP:0100957)	2.85640358
16	Pancreatic fibrosis (HP:0100732)	2.83264181
17	Type II lissencephaly (HP:0007260)	2.80144253
18	Hyperventilation (HP:0002883)	2.79723350
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.67030455
20	Genital tract atresia (HP:0001827)	2.66296108
21	Vaginal atresia (HP:0000148)	2.61096779
22	Limb dystonia (HP:0002451)	2.59898318
23	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.51049934
24	Polyphagia (HP:0002591)	2.50958669
25	Intestinal atresia (HP:0011100)	2.50256690
26	Inability to walk (HP:0002540)	2.50040561
27	Progressive cerebellar ataxia (HP:0002073)	2.49045644
28	Drooling (HP:0002307)	2.46315865
29	Cerebellar dysplasia (HP:0007033)	2.44482622
30	Abnormal respiratory motile cilium physiology (HP:0012261)	2.43353695
31	Abolished electroretinogram (ERG) (HP:0000550)	2.41713161
32	Abnormality of the labia minora (HP:0012880)	2.39796875
33	Pachygyria (HP:0001302)	2.39743990
34	Absent speech (HP:0001344)	2.36492665
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36224290
36	Absent/shortened dynein arms (HP:0200106)	2.36224290
37	Abnormal respiratory epithelium morphology (HP:0012253)	2.33670164
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33670164
39	Poor coordination (HP:0002370)	2.32783997
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32534998
41	Abnormality of the renal cortex (HP:0011035)	2.32386556
42	Thyroid-stimulating hormone excess (HP:0002925)	2.30209550
43	Abnormal ciliary motility (HP:0012262)	2.30025069
44	Renal cortical cysts (HP:0000803)	2.29844052
45	Attenuation of retinal blood vessels (HP:0007843)	2.27854649
46	Cortical dysplasia (HP:0002539)	2.25174295
47	Hypoplasia of the brainstem (HP:0002365)	2.23266188
48	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.23266188
49	Occipital encephalocele (HP:0002085)	2.22395256
50	Progressive inability to walk (HP:0002505)	2.20826475
51	Excessive salivation (HP:0003781)	2.19884074
52	Short tibia (HP:0005736)	2.19758797
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.19279030
54	Abnormality of the anterior horn cell (HP:0006802)	2.17699713
55	Degeneration of anterior horn cells (HP:0002398)	2.17699713
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.16975227
57	Spastic tetraplegia (HP:0002510)	2.16491310
58	Tubulointerstitial abnormality (HP:0001969)	2.16157368
59	Specific learning disability (HP:0001328)	2.15280328
60	Postaxial hand polydactyly (HP:0001162)	2.13631705
61	Narrow forehead (HP:0000341)	2.11768527
62	Acute necrotizing encephalopathy (HP:0006965)	2.11221362
63	Hypsarrhythmia (HP:0002521)	2.07904442
64	Abnormal mitochondria in muscle tissue (HP:0008316)	2.07410978
65	Febrile seizures (HP:0002373)	2.05097128
66	Postaxial foot polydactyly (HP:0001830)	2.03543643
67	Sclerocornea (HP:0000647)	2.02917984
68	Abnormality of macular pigmentation (HP:0008002)	2.02324024
69	Failure to thrive in infancy (HP:0001531)	1.96883752
70	Anencephaly (HP:0002323)	1.96375488
71	EEG with generalized epileptiform discharges (HP:0011198)	1.95654860
72	Optic nerve hypoplasia (HP:0000609)	1.95116491
73	Myokymia (HP:0002411)	1.93456096
74	Volvulus (HP:0002580)	1.91427088
75	Broad foot (HP:0001769)	1.90235645
76	Oculomotor apraxia (HP:0000657)	1.89829691
77	Increased CSF lactate (HP:0002490)	1.89402952
78	Atonic seizures (HP:0010819)	1.86454329
79	Pendular nystagmus (HP:0012043)	1.86300532
80	Rhinitis (HP:0012384)	1.86012151
81	Epileptiform EEG discharges (HP:0011182)	1.85676267
82	Mitochondrial inheritance (HP:0001427)	1.84565676
83	Cystic liver disease (HP:0006706)	1.82973734
84	Aplasia/Hypoplasia of the lens (HP:0008063)	1.82789873
85	Polymicrogyria (HP:0002126)	1.82513583
86	Astigmatism (HP:0000483)	1.82212365
87	Acute encephalopathy (HP:0006846)	1.81164245
88	Prominent nasal bridge (HP:0000426)	1.81033991
89	Abnormal hair whorl (HP:0010721)	1.80960109
90	Congenital stationary night blindness (HP:0007642)	1.80325146
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79911844
92	Hepatocellular necrosis (HP:0001404)	1.79046674
93	Hypothermia (HP:0002045)	1.76659750
94	Congenital hepatic fibrosis (HP:0002612)	1.76617955
95	Abnormality of the astrocytes (HP:0100707)	1.75756373
96	Astrocytoma (HP:0009592)	1.75756373
97	Decreased testicular size (HP:0008734)	1.75407058
98	Gaze-evoked nystagmus (HP:0000640)	1.74030423
99	Aganglionic megacolon (HP:0002251)	1.72288681
100	Short foot (HP:0001773)	1.72283495

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCR	3.69004721
2	MAP4K2	3.63920981
3	TRIM28	3.38137437
4	WNK3	3.23451299
5	MAP3K4	3.02990158
6	MARK1	2.98947178
7	MAP2K7	2.80244675
8	CASK	2.79118769
9	PINK1	2.34003485
10	MAPK13	2.16450679
11	CSNK1G3	2.10579733
12	CSNK1A1L	1.99787781
13	CSNK1G2	1.95757027
14	CSNK1G1	1.81132651
15	FRK	1.79262243
16	ZAK	1.67321011
17	SRPK1	1.66532767
18	BMPR1B	1.66452911
19	BCKDK	1.64296334
20	PLK4	1.60944582
21	PLK2	1.60364412
22	ERBB3	1.51116094
23	DYRK2	1.47946762
24	MINK1	1.46506836
25	EPHA3	1.43394064
26	INSRR	1.39331833
27	PNCK	1.37275202
28	TESK1	1.35000269
29	SIK3	1.27461224
30	EPHA4	1.25225104
31	TAOK3	1.22368179
32	NUAK1	1.20238089
33	MAP2K4	1.19432217
34	CCNB1	1.09560924
35	OXSR1	1.01954162
36	TNIK	1.01535133
37	ACVR1B	0.99281909
38	STK38L	0.98585248
39	PAK3	0.97916817
40	PIM2	0.97635399
41	SIK2	0.92352478
42	PRKCE	0.90110563
43	VRK1	0.87229387
44	DYRK3	0.86909077
45	STK39	0.85685377
46	ADRBK2	0.84252458
47	WNK4	0.83815853
48	PRKCG	0.80185506
49	GRK1	0.79195004
50	RPS6KA4	0.77122456
51	RPS6KA5	0.77081123
52	LIMK1	0.73406007
53	TIE1	0.71218898
54	BRD4	0.71173298
55	CAMK2A	0.65110767
56	STK16	0.56959837
57	CDK19	0.56925587
58	MUSK	0.56443714
59	PKN1	0.56402197
60	DAPK2	0.55129152
61	MAP3K5	0.54036036
62	PLK3	0.52915294
63	CDK14	0.52757599
64	CDK5	0.51401275
65	TSSK6	0.50498235
66	TESK2	0.49603664
67	CSNK1A1	0.48310783
68	ADRBK1	0.47709718
69	CSNK1D	0.46621714
70	PLK1	0.45787031
71	NEK1	0.45545271
72	NTRK2	0.45422732
73	UHMK1	0.45297425
74	MARK3	0.44799240
75	MAP3K6	0.44583242
76	ATM	0.43029478
77	PRKACA	0.42449751
78	GRK7	0.42225112
79	KSR1	0.40360526
80	ATR	0.39914798
81	DYRK1A	0.39292447
82	FER	0.38871282
83	EIF2AK3	0.37753435
84	PTK2B	0.37687263
85	PHKG1	0.36786242
86	PHKG2	0.36786242
87	CAMK4	0.35811074
88	PRKG1	0.35596973
89	PRKCZ	0.34086357
90	CDK3	0.33832293
91	DYRK1B	0.33205625
92	AKT3	0.32760910
93	CDK18	0.32638766
94	EGFR	0.32405977
95	PRKACB	0.31903415
96	MATK	0.31779341
97	CAMK2B	0.30880316
98	PAK6	0.30388428
99	FLT3	0.29962481
100	IRAK1	0.28827067

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.36746144
2	Protein export_Homo sapiens_hsa03060	3.22068837
3	Nicotine addiction_Homo sapiens_hsa05033	3.21962671
4	Butanoate metabolism_Homo sapiens_hsa00650	2.83865731
5	Phototransduction_Homo sapiens_hsa04744	2.79238343
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62648520
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.56580335
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.17593234
9	Basal transcription factors_Homo sapiens_hsa03022	2.16284953
10	Non-homologous end-joining_Homo sapiens_hsa03450	1.99604471
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98418222
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.97437179
13	GABAergic synapse_Homo sapiens_hsa04727	1.90247008
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.81595282
15	Olfactory transduction_Homo sapiens_hsa04740	1.73127598
16	Propanoate metabolism_Homo sapiens_hsa00640	1.72758362
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72008030
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.70644622
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69608288
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.64404202
21	Regulation of autophagy_Homo sapiens_hsa04140	1.63727613
22	Taste transduction_Homo sapiens_hsa04742	1.61380702
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.55667760
24	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.53990749
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.50503236
26	Parkinsons disease_Homo sapiens_hsa05012	1.48634004
27	Morphine addiction_Homo sapiens_hsa05032	1.42984542
28	RNA degradation_Homo sapiens_hsa03018	1.40513718
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.33110681
30	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.31958222
31	Huntingtons disease_Homo sapiens_hsa05016	1.27302650
32	RNA polymerase_Homo sapiens_hsa03020	1.27066450
33	Peroxisome_Homo sapiens_hsa04146	1.22178785
34	Circadian entrainment_Homo sapiens_hsa04713	1.19966650
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.17801395
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.16265017
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15589218
38	Cocaine addiction_Homo sapiens_hsa05030	1.13408364
39	Fatty acid elongation_Homo sapiens_hsa00062	1.11472969
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.07956512
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.06404433
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99757919
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99424913
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97246494
45	Base excision repair_Homo sapiens_hsa03410	0.94940310
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.94138091
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92054577
48	Serotonergic synapse_Homo sapiens_hsa04726	0.91686577
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90774284
50	Homologous recombination_Homo sapiens_hsa03440	0.89821600
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89798530
52	Alcoholism_Homo sapiens_hsa05034	0.89185750
53	RNA transport_Homo sapiens_hsa03013	0.88987989
54	Amphetamine addiction_Homo sapiens_hsa05031	0.87901320
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.86211708
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85495658
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85246196
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.83128184
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82363169
60	Oocyte meiosis_Homo sapiens_hsa04114	0.79298656
61	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78034641
62	Purine metabolism_Homo sapiens_hsa00230	0.77671854
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72955109
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72546577
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70300134
66	Alzheimers disease_Homo sapiens_hsa05010	0.68143705
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67011114
68	Insulin secretion_Homo sapiens_hsa04911	0.66622080
69	Axon guidance_Homo sapiens_hsa04360	0.66224728
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.62866942
71	Metabolic pathways_Homo sapiens_hsa01100	0.60613376
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58697551
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.58379233
74	Long-term depression_Homo sapiens_hsa04730	0.57942895
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.57897124
76	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57362353
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.55657307
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.52832122
79	Salivary secretion_Homo sapiens_hsa04970	0.52652175
80	Mismatch repair_Homo sapiens_hsa03430	0.52241345
81	Circadian rhythm_Homo sapiens_hsa04710	0.51193845
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50357465
83	Gap junction_Homo sapiens_hsa04540	0.43621130
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43439486
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.42536314
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.36491911
87	Phagosome_Homo sapiens_hsa04145	0.34612752
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.34469921
89	Proteasome_Homo sapiens_hsa03050	0.33830002
90	Spliceosome_Homo sapiens_hsa03040	0.33629218
91	mRNA surveillance pathway_Homo sapiens_hsa03015	0.33421338
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33009072
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.31465605
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31201685
95	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.30640695
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30242312
97	Fatty acid degradation_Homo sapiens_hsa00071	0.30110515
98	Retinol metabolism_Homo sapiens_hsa00830	0.28793505
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28388586
100	ABC transporters_Homo sapiens_hsa02010	0.26477358

CEP170P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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