CEP19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to centrosomes and primary cilia and co-localizes with a marker for the mother centriole. This gene resides in a region of human chromosome 3 that is linked to morbid obesity. A homozygous knockout of the orthologous gene in mouse resulted in mice with morbid obesity, hyperphagy, glucose intolerance, and insulin resistance. Mutations in this gene cause morbid obesity and spermatogenic failure (MOSPGF). This gene has a pseudogene on human chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.52080328
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.76101754
3vocalization behavior (GO:0071625)4.73416698
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67602849
5glutamate secretion (GO:0014047)4.63598051
6neuron cell-cell adhesion (GO:0007158)4.60445195
7protein localization to synapse (GO:0035418)4.53913191
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50669179
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.43782283
10regulation of synaptic vesicle exocytosis (GO:2000300)4.37425651
11neuronal action potential propagation (GO:0019227)4.36051292
12neural tube formation (GO:0001841)4.32854995
13behavioral response to nicotine (GO:0035095)4.28729971
14DNA deamination (GO:0045006)4.26536581
15synaptic vesicle maturation (GO:0016188)4.07414029
16regulation of glutamate receptor signaling pathway (GO:1900449)4.06566860
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00760789
18regulation of synaptic vesicle transport (GO:1902803)4.00043799
19postsynaptic membrane organization (GO:0001941)3.94156838
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91176105
21ATP hydrolysis coupled proton transport (GO:0015991)3.88717271
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.88717271
23platelet dense granule organization (GO:0060155)3.88154579
24neurotransmitter secretion (GO:0007269)3.86793209
25epithelial cilium movement (GO:0003351)3.84538654
26presynaptic membrane assembly (GO:0097105)3.83472190
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79799364
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.78730119
29neuron-neuron synaptic transmission (GO:0007270)3.75696415
30pyrimidine nucleobase catabolic process (GO:0006208)3.73016465
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.67874303
32transferrin transport (GO:0033572)3.66384386
33regulation of synapse structural plasticity (GO:0051823)3.64158429
34presynaptic membrane organization (GO:0097090)3.62787503
35synaptic transmission, glutamatergic (GO:0035249)3.61384928
36positive regulation of membrane potential (GO:0045838)3.60848237
37protein localization to cilium (GO:0061512)3.58825815
38fucose catabolic process (GO:0019317)3.58718224
39L-fucose metabolic process (GO:0042354)3.58718224
40L-fucose catabolic process (GO:0042355)3.58718224
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57165152
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53723231
43axoneme assembly (GO:0035082)3.53277056
44piRNA metabolic process (GO:0034587)3.50646560
45glutamate receptor signaling pathway (GO:0007215)3.50007956
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46443694
47behavioral response to cocaine (GO:0048148)3.45115268
48positive regulation of neurotransmitter transport (GO:0051590)3.40007532
49ATP synthesis coupled proton transport (GO:0015986)3.39113457
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39113457
51behavioral defense response (GO:0002209)3.37538787
52behavioral fear response (GO:0001662)3.37538787
53long-term synaptic potentiation (GO:0060291)3.37287939
54response to histamine (GO:0034776)3.36704700
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35005762
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33956358
57trivalent inorganic cation transport (GO:0072512)3.32659215
58ferric iron transport (GO:0015682)3.32659215
59locomotory exploration behavior (GO:0035641)3.31949664
60response to pheromone (GO:0019236)3.27427055
61regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26369007
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26369007
63neurotransmitter-gated ion channel clustering (GO:0072578)3.26283578
64regulation of neuronal synaptic plasticity (GO:0048168)3.25106020
65regulation of glutamate secretion (GO:0014048)3.23514744
66negative regulation of dendrite morphogenesis (GO:0050774)3.23488356
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.23201925
68fear response (GO:0042596)3.21725765
69protein complex biogenesis (GO:0070271)3.20183587
70adaptation of signaling pathway (GO:0023058)3.19534169
71cilium movement (GO:0003341)3.19514783
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18768828
73regulation of action potential (GO:0098900)3.18373277
74regulation of postsynaptic membrane potential (GO:0060078)3.16150766
75detection of calcium ion (GO:0005513)3.15930761
76neurotransmitter transport (GO:0006836)3.12505782
77chaperone-mediated protein transport (GO:0072321)3.11116679
78synaptic vesicle endocytosis (GO:0048488)3.10322257
79regulation of neurotransmitter secretion (GO:0046928)3.08582140
80protein neddylation (GO:0045116)3.07978502
81positive regulation of neurotransmitter secretion (GO:0001956)3.07256238
82negative regulation of mast cell activation (GO:0033004)3.04584107
83exploration behavior (GO:0035640)3.03499847
84cilium or flagellum-dependent cell motility (GO:0001539)3.02578059
85negative regulation of cation channel activity (GO:2001258)3.00985946
86activated T cell proliferation (GO:0050798)3.00499390
87neuron recognition (GO:0008038)3.00454064
88long-term memory (GO:0007616)3.00181289
89calcium ion-dependent exocytosis (GO:0017156)2.99889442
90synaptic transmission, dopaminergic (GO:0001963)2.98749643
91regulation of protein kinase A signaling (GO:0010738)2.98333069
92synaptic vesicle transport (GO:0048489)2.97926890
93establishment of synaptic vesicle localization (GO:0097480)2.97926890
94regulation of synaptic plasticity (GO:0048167)2.97550796
95regulation of cilium movement (GO:0003352)2.97247733
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96091578
97cornea development in camera-type eye (GO:0061303)2.95894267
98serotonin metabolic process (GO:0042428)2.95727816
99mitochondrial respiratory chain complex assembly (GO:0033108)2.95405403
100nucleobase catabolic process (GO:0046113)2.93723496
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93337165
102inositol phosphate catabolic process (GO:0071545)2.91762949
103regulation of neurotransmitter levels (GO:0001505)2.89921224
104regulation of vesicle fusion (GO:0031338)2.89587402
105positive regulation of synapse maturation (GO:0090129)2.88945125
106positive regulation of synapse assembly (GO:0051965)2.88312700
107respiratory electron transport chain (GO:0022904)2.87107421
108protein polyglutamylation (GO:0018095)2.86403376
109regulation of neurotransmitter transport (GO:0051588)2.86218998
110proline transport (GO:0015824)2.85887901
111membrane hyperpolarization (GO:0060081)2.85435453
112electron transport chain (GO:0022900)2.85177196
113regulation of voltage-gated calcium channel activity (GO:1901385)2.84377792
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83432536
115synaptic transmission (GO:0007268)2.83205408
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81772281
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81772281
118activation of protein kinase A activity (GO:0034199)2.81054275
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.79188582
120response to amphetamine (GO:0001975)2.78282536
121learning (GO:0007612)2.78172368
122intraciliary transport (GO:0042073)2.77434286
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77344803
124female mating behavior (GO:0060180)2.76077274
125negative regulation of dendrite development (GO:2000171)2.75901527
126gamma-aminobutyric acid transport (GO:0015812)2.75651563
127cytidine metabolic process (GO:0046087)2.75551271
128cytidine catabolic process (GO:0006216)2.75551271
129cytidine deamination (GO:0009972)2.75551271
130regulation of dopamine metabolic process (GO:0042053)2.75175159
131regulation of catecholamine metabolic process (GO:0042069)2.75175159
132negative regulation of telomere maintenance (GO:0032205)2.73225486
133regulation of memory T cell differentiation (GO:0043380)2.71826520
134nonmotile primary cilium assembly (GO:0035058)2.70649077
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64754440
136indolalkylamine metabolic process (GO:0006586)2.62022811
137microglial cell activation (GO:0001774)2.61623950
138cilium morphogenesis (GO:0060271)2.61620544
139cellular response to interleukin-15 (GO:0071350)2.61215879
140preassembly of GPI anchor in ER membrane (GO:0016254)2.60094821
141pyrimidine ribonucleoside catabolic process (GO:0046133)2.59991565
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.58433990
143NADH dehydrogenase complex assembly (GO:0010257)2.58433990
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58433990
145DNA methylation involved in gamete generation (GO:0043046)2.57208708
146rRNA catabolic process (GO:0016075)2.54661760
147axonemal dynein complex assembly (GO:0070286)2.54141736
148male meiosis I (GO:0007141)2.53385324
149cilium organization (GO:0044782)2.51864085
150indole-containing compound catabolic process (GO:0042436)2.49863645
151indolalkylamine catabolic process (GO:0046218)2.49863645
152tryptophan catabolic process (GO:0006569)2.49863645
153dopamine transport (GO:0015872)2.47955186
154neuronal action potential (GO:0019228)2.45562638
155retinal ganglion cell axon guidance (GO:0031290)2.43905515
156regulation of B cell receptor signaling pathway (GO:0050855)2.43587950
157leukocyte migration involved in inflammatory response (GO:0002523)2.43538802
158regulation of collateral sprouting (GO:0048670)2.43472603
159GPI anchor metabolic process (GO:0006505)2.43413693
160head development (GO:0060322)2.43358317
161spinal cord motor neuron differentiation (GO:0021522)2.40948542
162cilium assembly (GO:0042384)2.40778320
163positive regulation of defense response to virus by host (GO:0002230)2.40113134
164detection of light stimulus involved in visual perception (GO:0050908)2.38756463
165detection of light stimulus involved in sensory perception (GO:0050962)2.38756463
166multicellular organism reproduction (GO:0032504)2.38736585
167DNA double-strand break processing (GO:0000729)2.38157271
168photoreceptor cell development (GO:0042461)2.38120601
169positive regulation of T cell mediated cytotoxicity (GO:0001916)2.37869773
170regulation of meiosis I (GO:0060631)2.35808431
171neutrophil activation (GO:0042119)2.35260996
172negative regulation of heart rate (GO:0010459)2.35004851
173protein-cofactor linkage (GO:0018065)2.34437139
174cell proliferation in forebrain (GO:0021846)2.34177645
175opioid receptor signaling pathway (GO:0038003)2.33844626
176centriole replication (GO:0007099)2.33811177
177phosphatidylinositol acyl-chain remodeling (GO:0036149)2.32136788
178tryptophan metabolic process (GO:0006568)2.32095099
179RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.30744412
180cellular ketone body metabolic process (GO:0046950)2.30403759
181synapsis (GO:0007129)2.30177806
182male meiosis (GO:0007140)2.29735960
183pantothenate metabolic process (GO:0015939)2.28430766
184neutrophil mediated immunity (GO:0002446)2.28007388
185sequestering of actin monomers (GO:0042989)2.27091324
186water-soluble vitamin biosynthetic process (GO:0042364)2.26932324
187regulation of microtubule-based movement (GO:0060632)2.26830564
188negative regulation of cell killing (GO:0031342)2.26587669
189negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26587669
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.26093007
191startle response (GO:0001964)2.26009271
192cellular biogenic amine catabolic process (GO:0042402)2.25971528
193amine catabolic process (GO:0009310)2.25971528
194synaptic transmission, cholinergic (GO:0007271)2.25246164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23409857
2GBX2_23144817_ChIP-Seq_PC3_Human4.00283758
3TAF15_26573619_Chip-Seq_HEK293_Human3.15554761
4REST_21632747_ChIP-Seq_MESCs_Mouse2.75470315
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73618161
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.73295744
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65047322
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51624405
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45309203
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36251203
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33589210
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22434040
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.22238204
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.21051908
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15896557
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15701087
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11293564
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.11158873
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08688724
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04651702
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98590298
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94190373
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92024772
24FUS_26573619_Chip-Seq_HEK293_Human1.88778575
25VDR_22108803_ChIP-Seq_LS180_Human1.88590476
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86302005
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86302005
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86095643
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86032377
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82590037
31ZNF274_21170338_ChIP-Seq_K562_Hela1.79301273
32IGF1R_20145208_ChIP-Seq_DFB_Human1.78650555
33P300_19829295_ChIP-Seq_ESCs_Human1.78417603
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74515673
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73758261
36SMAD4_21799915_ChIP-Seq_A2780_Human1.73417928
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72970316
38TP53_22573176_ChIP-Seq_HFKS_Human1.71038232
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.68061648
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67825380
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65533576
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64186815
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.62955604
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61626728
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.60735620
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.57910308
47RNF2_27304074_Chip-Seq_NSC_Mouse1.57810049
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57044398
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.55644712
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.53847675
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53423550
52BCAT_22108803_ChIP-Seq_LS180_Human1.49884575
53IRF1_19129219_ChIP-ChIP_H3396_Human1.48827580
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47233570
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46882347
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.45596126
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.39876541
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38158029
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36471881
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.34373464
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.32258173
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32258173
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31880091
64DROSHA_22980978_ChIP-Seq_HELA_Human1.30798661
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.28037610
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.26111882
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25738360
68ER_23166858_ChIP-Seq_MCF-7_Human1.24828768
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23797284
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22662431
71AR_25329375_ChIP-Seq_VCAP_Human1.22095797
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21048179
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20283116
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19967070
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19952085
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.19352731
77NANOG_19829295_ChIP-Seq_ESCs_Human1.19136887
78SOX2_19829295_ChIP-Seq_ESCs_Human1.19136887
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18778705
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.18217966
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17984375
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17598140
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16878296
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16371291
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.16357118
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16269188
87JUN_21703547_ChIP-Seq_K562_Human1.16163685
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16148322
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15734846
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15441728
91MYC_18940864_ChIP-ChIP_HL60_Human1.14632035
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13132427
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11763577
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10509314
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09680271
96VDR_23849224_ChIP-Seq_CD4+_Human1.09131663
97GATA3_26560356_Chip-Seq_TH2_Human1.08769699
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08492116
99AR_20517297_ChIP-Seq_VCAP_Human1.08472885
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08059916
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06725711
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06280349
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.06084276
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05552190
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05259158
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04381700
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04254643
108IRF8_22096565_ChIP-ChIP_GC-B_Human1.04169966
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03690617
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.03211048
111TCF4_22108803_ChIP-Seq_LS180_Human1.03169997
112EWS_26573619_Chip-Seq_HEK293_Human1.02839537
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02565549
114NANOG_20526341_ChIP-Seq_ESCs_Human1.02483600
115TCF4_23295773_ChIP-Seq_U87_Human1.02062345
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01479177
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01371518
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01275426
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.00667754
120NCOR_22424771_ChIP-Seq_293T_Human1.00533223
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00129741
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99913381
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99598608
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.99448044
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99393924
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.99273620
127SOX9_26525672_Chip-Seq_HEART_Mouse0.98338807
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.97305611
129CBP_20019798_ChIP-Seq_JUKART_Human0.96520032
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96520032
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96467180
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96359603
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96359603
134RUNX2_22187159_ChIP-Seq_PCA_Human0.96264553
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.96215002
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95673436
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95623994
138KDM2B_26808549_Chip-Seq_REH_Human0.95295614
139P53_22387025_ChIP-Seq_ESCs_Mouse0.95267597
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94453601
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94213838
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93003756
143STAT3_23295773_ChIP-Seq_U87_Human0.92433214
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92080829
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.90608783
146REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90531004
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.89521955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.10815322
2MP0004859_abnormal_synaptic_plasticity5.00441004
3MP0003635_abnormal_synaptic_transmissio3.70881372
4MP0001968_abnormal_touch/_nociception3.34188041
5MP0009745_abnormal_behavioral_response3.32480045
6MP0002063_abnormal_learning/memory/cond3.10596452
7MP0004270_analgesia3.09748374
8MP0002064_seizures2.93827050
9MP0002736_abnormal_nociception_after2.85413266
10MP0002572_abnormal_emotion/affect_behav2.82248984
11MP0009046_muscle_twitch2.73524213
12MP0003724_increased_susceptibility_to2.70422621
13MP0002735_abnormal_chemical_nociception2.69067845
14MP0002272_abnormal_nervous_system2.59510643
15MP0006276_abnormal_autonomic_nervous2.58801359
16MP0000569_abnormal_digit_pigmentation2.55427311
17MP0003122_maternal_imprinting2.49031892
18MP0002822_catalepsy2.45884243
19MP0002734_abnormal_mechanical_nocicepti2.42253346
20MP0001501_abnormal_sleep_pattern2.33712530
21MP0001984_abnormal_olfaction2.29989406
22MP0001529_abnormal_vocalization2.29083977
23MP0005646_abnormal_pituitary_gland2.26767038
24MP0003879_abnormal_hair_cell2.21490567
25MP0001905_abnormal_dopamine_level2.16088599
26MP0001188_hyperpigmentation2.06484917
27MP0002102_abnormal_ear_morphology2.05658327
28MP0001486_abnormal_startle_reflex2.02155547
29MP0003787_abnormal_imprinting2.00424303
30MP0002067_abnormal_sensory_capabilities1.97177260
31MP0001440_abnormal_grooming_behavior1.95558796
32MP0002653_abnormal_ependyma_morphology1.92948587
33MP0001970_abnormal_pain_threshold1.92642091
34MP0002733_abnormal_thermal_nociception1.88555379
35MP0002557_abnormal_social/conspecific_i1.78903470
36MP0003646_muscle_fatigue1.76218676
37MP0005645_abnormal_hypothalamus_physiol1.75538746
38MP0000372_irregular_coat_pigmentation1.73532812
39MP0002277_abnormal_respiratory_mucosa1.71494154
40MP0005174_abnormal_tail_pigmentation1.71272426
41MP0003136_yellow_coat_color1.68311961
42MP0004924_abnormal_behavior1.67460537
43MP0005386_behavior/neurological_phenoty1.67460537
44MP0002184_abnormal_innervation1.62358968
45MP0003195_calcinosis1.59222947
46MP0005423_abnormal_somatic_nervous1.57906696
47MP0008877_abnormal_DNA_methylation1.54495880
48MP0004811_abnormal_neuron_physiology1.52378366
49MP0002837_dystrophic_cardiac_calcinosis1.50287090
50MP0002876_abnormal_thyroid_physiology1.48368689
51MP0003878_abnormal_ear_physiology1.47613078
52MP0005377_hearing/vestibular/ear_phenot1.47613078
53MP0002909_abnormal_adrenal_gland1.42257742
54MP0001502_abnormal_circadian_rhythm1.42104801
55MP0005671_abnormal_response_to1.41051902
56MP0001986_abnormal_taste_sensitivity1.39510467
57MP0008875_abnormal_xenobiotic_pharmacok1.38758148
58MP0008569_lethality_at_weaning1.37939149
59MP0004142_abnormal_muscle_tone1.36339076
60MP0003121_genomic_imprinting1.35020772
61MP0002095_abnormal_skin_pigmentation1.33641066
62MP0000427_abnormal_hair_cycle1.30682101
63MP0000778_abnormal_nervous_system1.29336917
64MP0002066_abnormal_motor_capabilities/c1.24487381
65MP0000955_abnormal_spinal_cord1.24449174
66MP0000013_abnormal_adipose_tissue1.23970697
67MP0005253_abnormal_eye_physiology1.23340735
68MP0002928_abnormal_bile_duct1.23274788
69MP0005075_abnormal_melanosome_morpholog1.21596721
70MP0003011_delayed_dark_adaptation1.19991016
71MP0002882_abnormal_neuron_morphology1.19260032
72MP0002638_abnormal_pupillary_reflex1.18681970
73MP0006292_abnormal_olfactory_placode1.18469785
74MP0003123_paternal_imprinting1.16295177
75MP0010386_abnormal_urinary_bladder1.14959809
76MP0009780_abnormal_chondrocyte_physiolo1.13338810
77MP0001919_abnormal_reproductive_system1.13202273
78MP0009785_altered_susceptibility_to1.12894530
79MP0000631_abnormal_neuroendocrine_gland1.08418825
80MP0008872_abnormal_physiological_respon1.07553659
81MP0005389_reproductive_system_phenotype1.07016990
82MP0009764_decreased_sensitivity_to1.06729485
83MP0005410_abnormal_fertilization1.04506852
84MP0001963_abnormal_hearing_physiology1.03457479
85MP0005394_taste/olfaction_phenotype1.02585148
86MP0005499_abnormal_olfactory_system1.02585148
87MP0001835_abnormal_antigen_presentation1.02432611
88MP0001800_abnormal_humoral_immune1.01512345
89MP0004858_abnormal_nervous_system1.00487283
90MP0004133_heterotaxia0.96021652
91MP0001324_abnormal_eye_pigmentation0.95189636
92MP0003633_abnormal_nervous_system0.92472684
93MP0005551_abnormal_eye_electrophysiolog0.90889432
94MP0002152_abnormal_brain_morphology0.90204524
95MP0002723_abnormal_immune_serum0.88621617
96MP0006036_abnormal_mitochondrial_physio0.88388235
97MP0005195_abnormal_posterior_eye0.87870547
98MP0006035_abnormal_mitochondrial_morpho0.87049361
99MP0004043_abnormal_pH_regulation0.86671890
100MP0000751_myopathy0.85682560
101MP0005387_immune_system_phenotype0.85611748
102MP0001790_abnormal_immune_system0.85611748
103MP0002069_abnormal_eating/drinking_beha0.84878430
104MP0002148_abnormal_hypersensitivity_rea0.84833936
105MP0006082_CNS_inflammation0.84801884
106MP0005535_abnormal_body_temperature0.82545295
107MP0002229_neurodegeneration0.82207617
108MP0008058_abnormal_DNA_repair0.81672893
109MP0001664_abnormal_digestion0.81457703
110MP0002938_white_spotting0.80470740
111MP0005409_darkened_coat_color0.79052184
112MP0003698_abnormal_male_reproductive0.77902654
113MP0004215_abnormal_myocardial_fiber0.77573040
114MP0004085_abnormal_heartbeat0.77238691
115MP0002751_abnormal_autonomic_nervous0.76227476
116MP0005084_abnormal_gallbladder_morpholo0.75779982
117MP0002693_abnormal_pancreas_physiology0.75615751
118MP0000685_abnormal_immune_system0.75118395
119MP0001929_abnormal_gametogenesis0.75057220
120MP0001485_abnormal_pinna_reflex0.75023503
121MP0002420_abnormal_adaptive_immunity0.74353686
122MP0002752_abnormal_somatic_nervous0.74325104
123MP0002452_abnormal_antigen_presenting0.73827646
124MP0003631_nervous_system_phenotype0.73491718
125MP0008874_decreased_physiological_sensi0.72766458
126MP0008789_abnormal_olfactory_epithelium0.69662442
127MP0000015_abnormal_ear_pigmentation0.68176918
128MP0003183_abnormal_peptide_metabolism0.67696661
129MP0006072_abnormal_retinal_apoptosis0.67622197
130MP0000026_abnormal_inner_ear0.67366912
131MP0001765_abnormal_ion_homeostasis0.67083356
132MP0004145_abnormal_muscle_electrophysio0.66942612
133MP0004742_abnormal_vestibular_system0.65653070
134MP0009379_abnormal_foot_pigmentation0.64525501
135MP0002160_abnormal_reproductive_system0.62702199
136MP0004147_increased_porphyrin_level0.62403012
137MP0002163_abnormal_gland_morphology0.59548074
138MP0000681_abnormal_thyroid_gland0.58498723
139MP0004885_abnormal_endolymph0.57768293
140MP0004484_altered_response_of0.56318738
141MP0005379_endocrine/exocrine_gland_phen0.55371002
142MP0003329_amyloid_beta_deposits0.54627889

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.84369423
2Myokymia (HP:0002411)5.52321372
3Atonic seizures (HP:0010819)4.95276393
4Epileptic encephalopathy (HP:0200134)4.74332873
5Visual hallucinations (HP:0002367)4.35340674
6Febrile seizures (HP:0002373)4.29316322
7Focal seizures (HP:0007359)4.28487620
8Pancreatic cysts (HP:0001737)4.14771564
9Abnormal hair whorl (HP:0010721)3.88773321
10Acute necrotizing encephalopathy (HP:0006965)3.77781508
11Hyperventilation (HP:0002883)3.76846951
12Abnormal mitochondria in muscle tissue (HP:0008316)3.60891588
13Absence seizures (HP:0002121)3.60277480
14Nephronophthisis (HP:0000090)3.58337506
15Progressive cerebellar ataxia (HP:0002073)3.58106996
16Mitochondrial inheritance (HP:0001427)3.46845070
17Dialeptic seizures (HP:0011146)3.28702899
18Progressive macrocephaly (HP:0004481)3.26903974
19Congenital stationary night blindness (HP:0007642)3.25612639
20Medial flaring of the eyebrow (HP:0010747)3.21622039
21Gait imbalance (HP:0002141)3.19752349
22Polyphagia (HP:0002591)3.07165263
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.06250347
24Absent/shortened dynein arms (HP:0200106)3.06250347
25Hepatocellular necrosis (HP:0001404)3.03111798
26Increased CSF lactate (HP:0002490)3.02516333
27Congenital primary aphakia (HP:0007707)3.02497952
28Nephrogenic diabetes insipidus (HP:0009806)3.00979243
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.93288076
30Stomatitis (HP:0010280)2.92278490
31Abnormal eating behavior (HP:0100738)2.88046044
32Generalized tonic-clonic seizures (HP:0002069)2.87912868
33Neuroendocrine neoplasm (HP:0100634)2.87895894
34Abnormality of the renal medulla (HP:0100957)2.82170382
35Poor suck (HP:0002033)2.79089243
36Impaired vibration sensation in the lower limbs (HP:0002166)2.77024364
37Progressive inability to walk (HP:0002505)2.76441385
38Pheochromocytoma (HP:0002666)2.74802498
39Abnormal rod and cone electroretinograms (HP:0008323)2.69988118
40Acute encephalopathy (HP:0006846)2.69278886
41Gaze-evoked nystagmus (HP:0000640)2.68133116
42Broad-based gait (HP:0002136)2.65305660
43Abnormal respiratory epithelium morphology (HP:0012253)2.63001025
44Abnormal respiratory motile cilium morphology (HP:0005938)2.63001025
45Chronic hepatic failure (HP:0100626)2.61877513
46Amblyopia (HP:0000646)2.61628738
47Anxiety (HP:0000739)2.60452023
48Limb dystonia (HP:0002451)2.56193374
49Inability to walk (HP:0002540)2.52959338
50Abolished electroretinogram (ERG) (HP:0000550)2.52876025
51Retrobulbar optic neuritis (HP:0100654)2.50852017
52Optic neuritis (HP:0100653)2.50852017
53Truncal ataxia (HP:0002078)2.48153420
54Agitation (HP:0000713)2.48120540
55Polydipsia (HP:0001959)2.48038558
56Abnormal drinking behavior (HP:0030082)2.48038558
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46508831
58Cystic liver disease (HP:0006706)2.45090753
59Failure to thrive in infancy (HP:0001531)2.44159757
60Abnormality of the renal cortex (HP:0011035)2.44097028
61Poor eye contact (HP:0000817)2.43857106
62Abnormal ciliary motility (HP:0012262)2.38805276
63Attenuation of retinal blood vessels (HP:0007843)2.38802133
64Hypothermia (HP:0002045)2.38602057
65Retinal dysplasia (HP:0007973)2.38049432
66Abnormal respiratory motile cilium physiology (HP:0012261)2.35611046
67Elevated erythrocyte sedimentation rate (HP:0003565)2.34951301
68Epileptiform EEG discharges (HP:0011182)2.26336079
69Increased hepatocellular lipid droplets (HP:0006565)2.25738268
70Pancreatic fibrosis (HP:0100732)2.25432972
71Genital tract atresia (HP:0001827)2.23445331
72Oligomenorrhea (HP:0000876)2.23102852
73Hypochromic microcytic anemia (HP:0004840)2.22850596
74Poor coordination (HP:0002370)2.22711335
75Vaginal atresia (HP:0000148)2.22258507
76Orchitis (HP:0100796)2.19397156
77Anencephaly (HP:0002323)2.17524849
78Protruding tongue (HP:0010808)2.16033851
79Stomach cancer (HP:0012126)2.14946209
80Hepatic necrosis (HP:0002605)2.12137839
81Pendular nystagmus (HP:0012043)2.11824834
82Myositis (HP:0100614)2.10882402
83Lissencephaly (HP:0001339)2.10652695
84Sleep apnea (HP:0010535)2.10516649
85Ankle clonus (HP:0011448)2.10223956
86Sclerocornea (HP:0000647)2.10179432
87Optic disc pallor (HP:0000543)2.07927878
88Molar tooth sign on MRI (HP:0002419)2.07788013
89Abnormality of midbrain morphology (HP:0002418)2.07788013
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.06751637
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06751637
92Specific learning disability (HP:0001328)2.05960753
93Lactic acidosis (HP:0003128)2.05252883
94Type II lissencephaly (HP:0007260)2.04484009
95Male pseudohermaphroditism (HP:0000037)2.03604375
96EEG with generalized epileptiform discharges (HP:0011198)2.03225827
97Furrowed tongue (HP:0000221)2.02949817
98Exercise intolerance (HP:0003546)2.02205285
99Depression (HP:0000716)2.01989339
100Decreased central vision (HP:0007663)2.01636216
101Amyotrophic lateral sclerosis (HP:0007354)2.01369029
102Rhinitis (HP:0012384)2.00763296
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00136189
104Congenital hepatic fibrosis (HP:0002612)1.99322667
105Dyskinesia (HP:0100660)1.97754426
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.96875604
107Delusions (HP:0000746)1.96815232
108Tubular atrophy (HP:0000092)1.96344949
1093-Methylglutaconic aciduria (HP:0003535)1.94999960
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94882382
111Abnormality of alanine metabolism (HP:0010916)1.94882382
112Hyperalaninemia (HP:0003348)1.94882382
113True hermaphroditism (HP:0010459)1.94290160
114Abnormality of the corticospinal tract (HP:0002492)1.93650046
115Increased serum lactate (HP:0002151)1.92285093
116Absent speech (HP:0001344)1.91919153
117Abnormal delayed hypersensitivity skin test (HP:0002963)1.90720787
118Impaired social interactions (HP:0000735)1.90549390
119Abnormal social behavior (HP:0012433)1.90549390
120Increased intramyocellular lipid droplets (HP:0012240)1.90337713
121Oligodactyly (hands) (HP:0001180)1.89171251
122Postaxial foot polydactyly (HP:0001830)1.88732384
123Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87842613
124Encephalitis (HP:0002383)1.87221105
125Hypsarrhythmia (HP:0002521)1.87041314
126Renal Fanconi syndrome (HP:0001994)1.86776835
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86170405
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86170405
129Postaxial hand polydactyly (HP:0001162)1.85280293
130Unsteady gait (HP:0002317)1.85158660
131Scanning speech (HP:0002168)1.84448044
132Polyuria (HP:0000103)1.83277165
133Impaired vibratory sensation (HP:0002495)1.83227175
134Abnormality of the labia minora (HP:0012880)1.81671187
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.81396367
136Genetic anticipation (HP:0003743)1.81242396
137Emotional lability (HP:0000712)1.80572277
138Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80368958
139Fetal akinesia sequence (HP:0001989)1.79423856
140Esotropia (HP:0000565)1.78942308
141Urinary bladder sphincter dysfunction (HP:0002839)1.78571348
142Limb ataxia (HP:0002070)1.78353377
143Neoplasm of the peripheral nervous system (HP:0100007)1.77935303
144Impaired smooth pursuit (HP:0007772)1.76247782
145Constricted visual fields (HP:0001133)1.76151820
146Dysdiadochokinesis (HP:0002075)1.75296131
147Dysmetria (HP:0001310)1.75185728
148Intestinal atresia (HP:0011100)1.74911696
149Excessive salivation (HP:0003781)1.74346968
150Drooling (HP:0002307)1.74346968
151Abnormality of the lower motor neuron (HP:0002366)1.73160701
152Volvulus (HP:0002580)1.72978972
153Retinitis pigmentosa (HP:0000510)1.71340187
154Episodic fever (HP:0001954)1.67803207
155Pachygyria (HP:0001302)1.67370721
156Occipital encephalocele (HP:0002085)1.67255451
157Concave nail (HP:0001598)1.64940408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.26217812
2MAP3K124.23281582
3NTRK33.81426167
4CASK3.70816086
5EPHA43.29887142
6MAP2K73.15155754
7MAP3K42.85711265
8TLK12.80739351
9CDK192.72652309
10MAP3K92.72045301
11CAMKK22.51763558
12PINK12.47934595
13DAPK12.24207701
14MINK12.17458210
15ARAF2.15508765
16SIK32.14894227
17PLK22.10399891
18GRK52.03508071
19MAP4K22.01170124
20TAOK31.98498147
21CCNB11.93249504
22TRIM281.93194837
23RIPK41.88069883
24NUAK11.87459096
25ZAK1.87411186
26DAPK21.86432644
27TXK1.82392085
28MAP2K41.67169867
29IRAK41.64877564
30MARK11.62540259
31GRK11.59564375
32TNIK1.55679288
33DYRK21.52364304
34STK161.50585249
35KSR11.48955102
36NME11.46533791
37PDK41.41520457
38PDK31.41520457
39BMPR21.38035741
40CAMKK11.35984617
41MAPK131.35463737
42PAK31.27545594
43TNK21.21621181
44PRPF4B1.20384489
45OXSR11.18979614
46CDK51.17859669
47TSSK61.17690056
48NTRK21.15720525
49PRKCG1.14924638
50MARK31.12879211
51BMPR1B1.12757607
52KSR21.09691213
53MAP4K11.05622425
54FES1.03458423
55BCKDK0.99402137
56MAP3K20.95064270
57AKT30.93481611
58CAMK2A0.91270387
59PTK2B0.90332706
60BRAF0.89881696
61BCR0.86318227
62CDK180.86210809
63MYLK0.84838371
64PNCK0.84188532
65STK110.82801798
66CAMK2B0.82590089
67MAPK150.82515489
68ADRBK20.78539297
69CAMK10.78353043
70EPHA30.77935851
71CDK140.76311670
72RAF10.75753548
73MUSK0.75476317
74TEC0.75327764
75CDK150.73702283
76DYRK1A0.71321414
77FGR0.71053699
78KIT0.70366519
79LYN0.69098684
80ADRBK10.68585613
81PRKCQ0.67721381
82INSRR0.67378511
83STK390.66831272
84CDK11A0.66661927
85SIK20.66333761
86SGK20.65472120
87CSK0.65393959
88UHMK10.64048548
89PAK60.63922346
90DYRK30.63283605
91PLK40.63236269
92CDK80.63008390
93SGK4940.62841263
94SGK2230.62841263
95PKN10.62660954
96WNK30.62188946
97PLK30.60621524
98GRK70.60499115
99PRKD30.60017073
100VRK10.60006761
101MATK0.59821421
102MAP3K130.59768909
103CSNK1G20.59566667
104IRAK10.58324345
105ITK0.57266461
106BTK0.56361911
107PDK20.56216537
108GRK60.54931149
109CDK30.53877932
110ERBB30.53217562
111PRKCZ0.51684256
112PRKCE0.51406345
113NEK20.49688901
114MAP3K50.48525335
115PDK10.48302229
116WNK40.47160979
117LCK0.46877089
118NTRK10.46834360
119CSNK1G30.46038482
120SYK0.45403755
121BLK0.43600105
122HCK0.42330076
123MAP2K60.41942217
124MKNK20.41526508
125TYK20.41451341
126CAMK2D0.40163336
127IKBKE0.39860222
128JAK20.39211384
129CSNK1G10.39162843
130ACVR1B0.38458065
131CAMK40.38035978
132CAMK2G0.37212082
133STK380.36702266
134CSNK1A1L0.35433167
135IKBKB0.35323395
136CSF1R0.34903557
137PRKACA0.33818848
138LIMK10.33788012
139DAPK30.33126659
140PRKCH0.32573091
141NLK0.32559320
142MAP2K10.32281615
143BRSK10.31794352
144PHKG20.28779250
145PHKG10.28779250
146PDPK10.28519156
147NEK10.28508631
148SGK10.26196089

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.86378628
2Nicotine addiction_Homo sapiens_hsa050333.59747537
3Collecting duct acid secretion_Homo sapiens_hsa049663.26528474
4Oxidative phosphorylation_Homo sapiens_hsa001903.19072187
5Olfactory transduction_Homo sapiens_hsa047402.91772339
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65615186
7Parkinsons disease_Homo sapiens_hsa050122.64147699
8Long-term potentiation_Homo sapiens_hsa047202.61656530
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60940277
10Amphetamine addiction_Homo sapiens_hsa050312.59833937
11Circadian entrainment_Homo sapiens_hsa047132.54649528
12GABAergic synapse_Homo sapiens_hsa047272.36289260
13Morphine addiction_Homo sapiens_hsa050322.33485752
14Dopaminergic synapse_Homo sapiens_hsa047282.25362967
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23580377
16Linoleic acid metabolism_Homo sapiens_hsa005912.18357188
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18311050
18Vibrio cholerae infection_Homo sapiens_hsa051102.16367899
19Alzheimers disease_Homo sapiens_hsa050102.15815512
20Glutamatergic synapse_Homo sapiens_hsa047242.15665852
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12281577
22Butanoate metabolism_Homo sapiens_hsa006502.08665632
23Huntingtons disease_Homo sapiens_hsa050161.95313480
24Taste transduction_Homo sapiens_hsa047421.94852200
25Selenocompound metabolism_Homo sapiens_hsa004501.84554919
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83062549
27Insulin secretion_Homo sapiens_hsa049111.82044435
28Salivary secretion_Homo sapiens_hsa049701.79790637
29Serotonergic synapse_Homo sapiens_hsa047261.78448424
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68568938
31Primary immunodeficiency_Homo sapiens_hsa053401.67330694
32Nitrogen metabolism_Homo sapiens_hsa009101.64267856
33Ether lipid metabolism_Homo sapiens_hsa005651.59702107
34Cardiac muscle contraction_Homo sapiens_hsa042601.59416954
35Cholinergic synapse_Homo sapiens_hsa047251.55383329
36Calcium signaling pathway_Homo sapiens_hsa040201.51920047
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49155153
38Cocaine addiction_Homo sapiens_hsa050301.46998277
39Renin secretion_Homo sapiens_hsa049241.45021540
40Fanconi anemia pathway_Homo sapiens_hsa034601.40695591
41Gastric acid secretion_Homo sapiens_hsa049711.40577925
42Phototransduction_Homo sapiens_hsa047441.40012976
43Caffeine metabolism_Homo sapiens_hsa002321.39612135
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36839085
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36663623
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36259262
47Long-term depression_Homo sapiens_hsa047301.33972564
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.30543419
49Homologous recombination_Homo sapiens_hsa034401.30187347
50Oxytocin signaling pathway_Homo sapiens_hsa049211.29984803
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19830731
52Proteasome_Homo sapiens_hsa030501.16303959
53Oocyte meiosis_Homo sapiens_hsa041141.14712113
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.12133018
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07969127
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07794762
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06708222
58Gap junction_Homo sapiens_hsa045401.03712558
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02931790
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02642363
61Peroxisome_Homo sapiens_hsa041461.00852792
62Dorso-ventral axis formation_Homo sapiens_hsa043200.99053124
63GnRH signaling pathway_Homo sapiens_hsa049120.97959805
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97879549
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97378079
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94769372
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93137747
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93069803
69cAMP signaling pathway_Homo sapiens_hsa040240.91715467
70Rheumatoid arthritis_Homo sapiens_hsa053230.91140173
71Graft-versus-host disease_Homo sapiens_hsa053320.90649108
72Arachidonic acid metabolism_Homo sapiens_hsa005900.89303058
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84765461
74Allograft rejection_Homo sapiens_hsa053300.84331468
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84066195
76Melanogenesis_Homo sapiens_hsa049160.82636939
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80360568
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79246067
79Autoimmune thyroid disease_Homo sapiens_hsa053200.77481975
80Tryptophan metabolism_Homo sapiens_hsa003800.76392873
81Alcoholism_Homo sapiens_hsa050340.72683405
82Pyruvate metabolism_Homo sapiens_hsa006200.70954438
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70578069
84Hematopoietic cell lineage_Homo sapiens_hsa046400.69537935
85Estrogen signaling pathway_Homo sapiens_hsa049150.69497148
86Propanoate metabolism_Homo sapiens_hsa006400.68797406
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.67851618
88Protein export_Homo sapiens_hsa030600.67698814
89ABC transporters_Homo sapiens_hsa020100.67334432
90Tuberculosis_Homo sapiens_hsa051520.66256471
91Leishmaniasis_Homo sapiens_hsa051400.60932631
92Chemokine signaling pathway_Homo sapiens_hsa040620.60815241
93Pancreatic secretion_Homo sapiens_hsa049720.60083853
94Thyroid hormone synthesis_Homo sapiens_hsa049180.59523888
95Type I diabetes mellitus_Homo sapiens_hsa049400.59504218
96Asthma_Homo sapiens_hsa053100.59299825
97Staphylococcus aureus infection_Homo sapiens_hsa051500.57864094
98Glucagon signaling pathway_Homo sapiens_hsa049220.57481125
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55364449
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53706552
101Circadian rhythm_Homo sapiens_hsa047100.52861819
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52713841
103Osteoclast differentiation_Homo sapiens_hsa043800.52528099
104Purine metabolism_Homo sapiens_hsa002300.48648681
105Legionellosis_Homo sapiens_hsa051340.47385132
106Axon guidance_Homo sapiens_hsa043600.46253315
107ErbB signaling pathway_Homo sapiens_hsa040120.46227372
108Hedgehog signaling pathway_Homo sapiens_hsa043400.46081613
109Phagosome_Homo sapiens_hsa041450.46019870
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45782049
111RNA polymerase_Homo sapiens_hsa030200.45624362
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.45349141
113Steroid biosynthesis_Homo sapiens_hsa001000.45218982
114Glioma_Homo sapiens_hsa052140.45111003
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44571471
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41720648
117Ovarian steroidogenesis_Homo sapiens_hsa049130.41338623
118Chemical carcinogenesis_Homo sapiens_hsa052040.41007817
119MAPK signaling pathway_Homo sapiens_hsa040100.40638363
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.40482235
121Measles_Homo sapiens_hsa051620.39374034
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38342812
123Metabolic pathways_Homo sapiens_hsa011000.36946966
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36515882
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35080531
126Antigen processing and presentation_Homo sapiens_hsa046120.34816588
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33905475
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33510312
129Regulation of autophagy_Homo sapiens_hsa041400.33324472
130Non-homologous end-joining_Homo sapiens_hsa034500.32689290
131beta-Alanine metabolism_Homo sapiens_hsa004100.32208356
132Ras signaling pathway_Homo sapiens_hsa040140.31119575
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30505716
134N-Glycan biosynthesis_Homo sapiens_hsa005100.29491909
135Type II diabetes mellitus_Homo sapiens_hsa049300.25638582
136Wnt signaling pathway_Homo sapiens_hsa043100.25388916
137Basal transcription factors_Homo sapiens_hsa030220.24745697
138Fructose and mannose metabolism_Homo sapiens_hsa000510.24511677
139VEGF signaling pathway_Homo sapiens_hsa043700.24396789
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.20160523
141Inositol phosphate metabolism_Homo sapiens_hsa005620.19514819
142Rap1 signaling pathway_Homo sapiens_hsa040150.18097815
143RNA degradation_Homo sapiens_hsa030180.17623731
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17433158
145Thyroid cancer_Homo sapiens_hsa052160.16997395
146African trypanosomiasis_Homo sapiens_hsa051430.16079059
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15876081
148Endocytosis_Homo sapiens_hsa041440.15734895
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14147671
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.14099273
151Dilated cardiomyopathy_Homo sapiens_hsa054140.13853047
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12392627
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.10130086
154Choline metabolism in cancer_Homo sapiens_hsa052310.09601748

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